                         SEQUENCE LISTING

<110>  Alpha Anomeric SAS
 
<120>  NUCLEIC ACID DUPLEXES

<130>  P6082PC00

<150>  EP20209313.4
<151>  2020-11-23

<160>  80    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  alpha anomeric bicyclo-DNA (abcDNA)

<400>  1
agccgaatgg a                                                            11


<210>  2
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  abcDNA

<400>  2
ttggagccga atgga                                                        15


<210>  3
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  abcDNA

<400>  3
ggtttggagc cgaatgga                                                     18


<210>  4
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  abcDNA

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  phosphorothioate linkage between A at position 15 and palmitic 
       acid

<220>
<221>  misc_binding
<222>  (15)..(15)
<223>  palmitic acid

<400>  4
tccattcggc tccaa                                                        15


<210>  5
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  abcDNA

<400>  5
tccattcggc tccaa                                                        15


<210>  6
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  abcDNA

<220>
<221>  misc_feature
<223>  Phosphorothioate linkages between all nucleosides.

<400>  6
tccattcggc tccaa                                                        15


<210>  7
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  PMO (phosphorodiamidate morpholino oligomer)

<400>  7
aggtaagccg a                                                            11


<210>  8
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  PMO

<400>  8
aggtaagccg aggtt                                                        15


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  PMO

<400>  9
aggtaagccg aggtttgg                                                     18


<210>  10
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  PMO

<400>  10
ggccaaacct cggcttacct gaaat                                             25


<210>  11
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  2'-MOE oligonucleotide

<400>  11
aggtaagccg a                                                            11


<210>  12
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  2'-MOE oligonucleotide

<400>  12
aggtaagccg aggtt                                                        15


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  2'-MOE oligonucleotide

<400>  13
aggtaagccg aggtttgg                                                     18


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  2'-MOE oligonucleotide

<220>
<221>  misc_feature
<223>  Phosphorothioate linkages between all nucleosides.

<400>  14
ccaaacctcg gcttacct                                                     18


<210>  15
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  15
aggtaagccg a                                                            11


<210>  16
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  16
aggtaagccg aggtt                                                        15


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  17
aggtaagccg aggtttgg                                                     18


<210>  18
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  FANA oligonucleotide.

<400>  18
aggtaagccg a                                                            11


<210>  19
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  FANA oligonucleotide

<400>  19
aggtaagccg aggtt                                                        15


<210>  20
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  FANA oligonucleotide

<400>  20
aggtaagccg aggtttgg                                                     18


<210>  21
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  2'-OMe oligonucleotide.

<400>  21
aggtaagccg a                                                            11


<210>  22
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  2'-OMe oligonucleotide.

<400>  22
aggtaagccg aggtt                                                        15


<210>  23
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  2'-OMe oligonucleotide.

<400>  23
aggtaagccg aggtttgg                                                     18


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  2'-OMe oligonucleotide.

<400>  24
ggccaaaccu cggcuuaccu                                                   20


<210>  25
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  25
agguaagccg agguu                                                        15


<210>  26
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  26
agguaagccg agguuugg                                                     18


<210>  27
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  27
auuucaggua agccgagguu uggcc                                             25


<210>  28
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linkage

<400>  28
aggtaagccg aggtt                                                        15


<210>  29
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linkage

<400>  29
aggtaagccg aggtt                                                        15


<210>  30
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linkage

<400>  30
aggtaagccg aggtt                                                        15


<210>  31
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-MOE nucleoside

<400>  31
aggtaagccg aggtt                                                        15


<210>  32
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-MOE nucleosides

<400>  32
aggtaagccg aggtt                                                        15


<210>  33
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-MOE nucleoside

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-MOE nucleosides

<400>  33
aggtaagccg aggtt                                                        15


<210>  34
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  34
tttttctttt tcttcttttt tcctttttgc aaaaacccaa aatattttag ctcctactca       60

gactgttact ctggtgacac aacctgtggt tactaaggaa actgccatct ccaaactaga      120

aatgccatct tccttgatgt tggaggtacc tgctctggca gatttcaacc gggcttggac      180

agaacttacc gactggcttt ctctgcttga tcaagttata aaatcacaga gggtgatggt      240

gggtgacctt gaggatatca acgagatgat catcaagcag aaggtatgag aaaaaatgat      300

aaaagttggc agaagttttt ctttaaaatg aag                                   333


<210>  35
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  35
ccaaactaga aatgccatct tccttgatgt                                        30


<210>  36
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  36
ctttacggta gaaggaact                                                    19


<210>  37
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  37
ttgatcttta cggtagaa                                                     18


<210>  38
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  38
tgatctttac ggtagaag                                                     18


<210>  39
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  39
ctttacggta gaaggaa                                                      17


<210>  40
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  40
tttacggtag aaggaac                                                      17


<210>  41
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  41
ttacggtaga aggaact                                                      17


<210>  42
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  42
ctttacggta gaagga                                                       16


<210>  43
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  43
tttacggtag aaggaa                                                       16


<210>  44
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  44
ttacggtaga aggaac                                                       16


<210>  45
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  45
tacggtagaa ggaact                                                       16


<210>  46
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  46
ctttacggta gaagg                                                        15


<210>  47
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  47
tttacggtag aagga                                                        15


<210>  48
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  48
ttacggtaga aggaa                                                        15


<210>  49
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  49
tacggtagaa ggaac                                                        15


<210>  50
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  50
acggtagaag gaact                                                        15


<210>  51
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  51
ctttacggta gaag                                                         14


<210>  52
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  52
tttacggtag aagg                                                         14


<210>  53
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  53
ttacggtaga agga                                                         14


<210>  54
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  54
tacggtagaa ggaa                                                         14


<210>  55
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  a, g, t, c corresponds to abc-DNA modified adenine, guanine, 
       thymine and methylcytosine, respectively.

<400>  55
ctttacggta gaaggaac                                                     18


<210>  56
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  a, g, t, c corresponds to abc-DNA modified adenine, guanine, 
       thymine and methylcytosine, respectively.

<400>  56
tttacggtag aaggaact                                                     18


<210>  57
<211>  312
<212>  DNA
<213>  Homo sapiens

<400>  57
cctccagact agcatttact actatatatt tatttttcct tttattctag ttgaaagaat       60

tcagaatcag tgggatgaag tacaagaaca ccttcagaac cggaggcaac agttgaatga      120

aatgttaaag gattcaacac aatggctgga agctaaggaa gaagctgagc aggtcttagg      180

acaggccaga gccaagcttg agtcatggaa ggagggtccc tatacagtag atgcaatcca      240

aaagaaaatc acagaaacca aggttagtat caaagatacc tttttaaaat aaaatactgg      300

ttacatttga ta                                                          312


<210>  58
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  58
gtacaagaac accttcagaa ccggaggcaa cagttgaatg aaatgttaa                   49


<210>  59
<211>  276
<212>  DNA
<213>  Homo sapiens

<400>  59
taaaaagaca tggggcttca tttttgtttt gcctttttgg tatcttacag gaactccagg       60

atggcattgg gcagcggcaa actgttgtca gaacattgaa tgcaactggg gaagaaataa      120

ttcagcaatc ctcaaaaaca gatgccagta ttctacagga aaaattggga agcctgaatc      180

tgcggtggca ggaggtctgc aaacagctgt cagacagaaa aaagaggtag ggcgacagat      240

ctaataggaa tgaaaacatt ttagcagact ttttaa                                276


<210>  60
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  60
ggtatcttac aggaactcca ggatggcatt gggcagcggc aaactgt                     47


<210>  61
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  PMO (phosphorodiamidate morpholino oligomer)

<400>  61
ctccaacatc aaggaagatg gcatttctag                                        30


<210>  62
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<223>  FANA oligonucleotide.

<400>  62
cuagaaaugc c                                                            11


<210>  63
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  abc DNA

<400>  63
gtcagctgcc aatgct                                                       16


<210>  64
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  abc DNA

<400>  64
gtcagctgcc aatgct                                                       16


<210>  65
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  abc DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  abc DNA

<400>  65
gtcagctgcc aatgct                                                       16


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  abc DNA

<400>  66
gggtcagctg ccaatgctag                                                   20


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  abc DNA

<220>
<221>  misc_feature
<222>  (6)..(15)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  abc DNA

<400>  67
gggtcagctg ccaatgctag                                                   20


<210>  68
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  abc DNA

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  abc DNA

<400>  68
gggtcagctg ccaatgct                                                     18


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  abc DNA

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  abc DNA

<400>  69
gggtcagctg ccaatgctag                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  abcDNA

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  abcDNA

<400>  70
ctagcauugg cagcugaccc                                                   20


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  abcDNA

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  abcDNA

<400>  71
ctagcauugg cagcugaccc                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-MOE nucleoside

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  2'-MOE nucleoside

<400>  72
gggtcagctg ccaatgctag                                                   20


<210>  73
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  73
gtcagctgcc aatgct                                                       16


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  74
gggtcagctg ccaatgctag                                                   20


<210>  75
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  75
agcattggca gctgac                                                       16


<210>  76
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  76
agcattggca gctgaccc                                                     18


<210>  77
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  77
ctagcattgg cagctgaccc                                                   20


<210>  78
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  78
agcauuggca gcugac                                                       16


<210>  79
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  79
agcauuggca gcugaccc                                                     18


<210>  80
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  80
cuagcauugg cagcugaccc                                                   20


