                         SEQUENCE LISTING

<110>  THE HOSPITAL FOR SICK CHILDREN
 
<120>  POLYPEPTIDES TARGETING DR4 AND/OR DR5 AND RELATED COMPOSITIONS 
       AND METHODS

<130>  3206-5046 (169488) ELL

<140>  PCT/CA2021/051690
<141>  2021-11-25

<150>  US 63/118306
<151>  2020-11-25

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "N" apoferritin

<400>  1

Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      


Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          


Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              


Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  


Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  


Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp 
                85                  90  


<210>  2
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "C" apoferritin

<400>  2

Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
1               5                   10                  15      


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
            20                  25                  30          


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
        35                  40                  45              


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
    50                  55                  60                  


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
65                  70                  75                  80  


Thr Leu Arg His Asp 
                85  


<210>  3
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "C" apoferritin

<400>  3

Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
1               5                   10                  15      


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
            20                  25                  30          


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
        35                  40                  45              


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
    50                  55                  60                  


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
65                  70                  75                  80  


Thr Leu Lys His Asp 
                85  


<210>  4
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  4

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25          


<210>  5
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  5

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            20                  25      


<210>  6
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  6

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser 
65                  70  


<210>  7
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc chain 1

<400>  7

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
        195                 200                 205             


His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  8
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc chain 2

<400>  8

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  9
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conatumumab light chain

<400>  9

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  10
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conatumumab Fab heavy chain

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Phe Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile His Asn Ser Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Gly Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys 
225 


<210>  11
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ferritin

<400>  11

Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      


Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          


Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              


Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  


Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  


Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      


Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         


Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp 
        115                 120                 125             


Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
    130                 135                 140                 


Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala 
145                 150                 155                 160 


Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Arg His Asp 
                165                 170                 175 


<210>  12
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conatumumab-hFerr

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
        275                 280                 285             


Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser 
    290                 295                 300                 


Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly Asp Tyr Phe 
305                 310                 315                 320 


Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                325                 330                 335     


His Ile His Asn Ser Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
            340                 345                 350         


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Gln Phe Ser Leu Arg 
        355                 360                 365             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Asp Arg Gly Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
385                 390                 395                 400 


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
                405                 410                 415     


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
            420                 425                 430         


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        435                 440                 445             


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    450                 455                 460                 


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
465                 470                 475                 480 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
                485                 490                 495     


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg 
    530                 535                 540                 


Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn 
545                 550                 555                 560 


Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe 
                565                 570                 575     


Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu 
            580                 585                 590         


Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln 
        595                 600                 605             


Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala 
    610                 615                 620                 


Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala 
625                 630                 635                 640 


Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly 
                645                 650                 655     


Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe 
            660                 665                 670         


Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr 
        675                 680                 685             


Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu 
    690                 695                 700                 


Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710             


<210>  13
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conatumumab-hFerr

<400>  13

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
        275                 280                 285             


Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser 
    290                 295                 300                 


Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly Asp Tyr Phe 
305                 310                 315                 320 


Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                325                 330                 335     


His Ile His Asn Ser Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
            340                 345                 350         


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Gln Phe Ser Leu Arg 
        355                 360                 365             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Asp Arg Gly Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
385                 390                 395                 400 


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
                405                 410                 415     


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
            420                 425                 430         


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        435                 440                 445             


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    450                 455                 460                 


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
465                 470                 475                 480 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
                485                 490                 495     


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln 
    530                 535                 540                 


Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu 
545                 550                 555                 560 


Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp 
                565                 570                 575     


Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu 
            580                 585                 590         


Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn 
        595                 600                 605             


Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu 
    610                 615                 620                 


Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu 
625                 630                 635                 640 


Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser 
                645                 650                 655     


Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu 
            660                 665                 670         


Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn 
        675                 680                 685             


Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe 
    690                 695                 700                 


Glu Arg Leu Thr Leu Arg His Asp 
705                 710         


<210>  14
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tigatuzumab-hFerr

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Arg Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        275                 280                 285             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    290                 295                 300                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Val Met Ser Trp Val 
305                 310                 315                 320 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
                325                 330                 335     


Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
            340                 345                 350         


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        355                 360                 365             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Asp 
    370                 375                 380                 


Ser Met Ile Thr Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly 
            500                 505                 510         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp 
    530                 535                 540                 


Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser 
545                 550                 555                 560 


Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala 
                565                 570                 575     


Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg 
            580                 585                 590         


Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg 
        595                 600                 605             


Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys 
    610                 615                 620                 


Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn 
625                 630                 635                 640 


Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro 
                645                 650                 655     


His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys 
            660                 665                 670         


Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly 
        675                 680                 685             


Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu 
    690                 695                 700                 


Arg His Asp 
705         


<210>  15
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tigatuzumab-hFerr

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Arg Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        275                 280                 285             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    290                 295                 300                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Val Met Ser Trp Val 
305                 310                 315                 320 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
                325                 330                 335     


Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
            340                 345                 350         


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        355                 360                 365             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Asp 
    370                 375                 380                 


Ser Met Ile Thr Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Arg Val Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly 
            500                 505                 510         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val 
    530                 535                 540                 


Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr 
545                 550                 555                 560 


Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu 
                565                 570                 575     


Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu 
            580                 585                 590         


Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala 
        595                 600                 605             


Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr 
    610                 615                 620                 


Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln 
625                 630                 635                 640 


Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His 
                645                 650                 655     


Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu 
            660                 665                 670         


Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly 
        675                 680                 685             


Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Arg 
    690                 695                 700                 


His Asp 
705     


<210>  16
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lexatumumab-hFerr

<400>  16

Leu Glu Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        275                 280                 285             


Gln Ser Gly Gly Gly Val Glu Arg Pro Gly Gly Ser Leu Arg Leu Ser 
    290                 295                 300                 


Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser Trp Val 
305                 310                 315                 320 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp 
                325                 330                 335     


Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Val Thr 
            340                 345                 350         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        355                 360                 365             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ile Leu Gly 
    370                 375                 380                 


Ala Gly Arg Gly Trp Tyr Phe Asp Leu Trp Gly Lys Gly Thr Thr Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr 
    530                 535                 540                 


Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu 
545                 550                 555                 560 


Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp 
                565                 570                 575     


Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu 
            580                 585                 590         


Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg 
        595                 600                 605             


Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu 
    610                 615                 620                 


Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys 
625                 630                 635                 640 


Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
                645                 650                 655     


Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
            660                 665                 670         


Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His 
        675                 680                 685             


Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg 
    690                 695                 700                 


Leu Thr Leu Arg His Asp 
705                 710 


<210>  17
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lexatumumab-hFerr

<400>  17

Leu Glu Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        275                 280                 285             


Gln Ser Gly Gly Gly Val Glu Arg Pro Gly Gly Ser Leu Arg Leu Ser 
    290                 295                 300                 


Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser Trp Val 
305                 310                 315                 320 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp 
                325                 330                 335     


Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Val Thr 
            340                 345                 350         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        355                 360                 365             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ile Leu Gly 
    370                 375                 380                 


Ala Gly Arg Gly Trp Tyr Phe Asp Leu Trp Gly Lys Gly Thr Thr Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser 
    530                 535                 540                 


Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln 
545                 550                 555                 560 


Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp 
                565                 570                 575     


Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu 
            580                 585                 590         


Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly 
        595                 600                 605             


Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp 
    610                 615                 620                 


Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
625                 630                 635                 640 


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
                645                 650                 655     


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
            660                 665                 670         


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
        675                 680                 685             


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
    690                 695                 700                 


Thr Leu Arg His Asp 
705                 


<210>  18
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Drozitumab-hFerr

<400>  18

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Ser Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Ala Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Ala Asp Ser Ser Gly Asn His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln 
        275                 280                 285             


Ser Gly Gly Gly Val Glu Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met Ser Trp Val Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp Gln 
                325                 330                 335     


Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Val Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ile Leu Gly Ala 
    370                 375                 380                 


Gly Arg Gly Trp Tyr Phe Asp Tyr Trp Gly Lys Gly Thr Thr Val Thr 
385                 390                 395                 400 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                405                 410                 415     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            420                 425                 430         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        435                 440                 445             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    450                 455                 460                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
465                 470                 475                 480 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                485                 490                 495     


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr 
    530                 535                 540                 


Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala 
545                 550                 555                 560 


Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val 
                565                 570                 575     


Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys 
            580                 585                 590         


Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly 
        595                 600                 605             


Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly 
    610                 615                 620                 


Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu 
625                 630                 635                 640 


Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp 
                645                 650                 655     


Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val 
            660                 665                 670         


Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg Leu 
        675                 680                 685             


Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr 
    690                 695                 700                 


Leu Arg His Asp 
705             


<210>  19
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Drozitumab-hFerr

<400>  19

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Ser Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Ala Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Ala Asp Ser Ser Gly Asn His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln 
        275                 280                 285             


Ser Gly Gly Gly Val Glu Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met Ser Trp Val Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp Gln 
                325                 330                 335     


Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Val Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ile Leu Gly Ala 
    370                 375                 380                 


Gly Arg Gly Trp Tyr Phe Asp Tyr Trp Gly Lys Gly Thr Thr Val Thr 
385                 390                 395                 400 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                405                 410                 415     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            420                 425                 430         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        435                 440                 445             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    450                 455                 460                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
465                 470                 475                 480 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                485                 490                 495     


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp 
    530                 535                 540                 


Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser 
545                 550                 555                 560 


Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala 
                565                 570                 575     


Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg 
            580                 585                 590         


Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg 
        595                 600                 605             


Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys 
    610                 615                 620                 


Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn 
625                 630                 635                 640 


Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro 
                645                 650                 655     


His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys 
            660                 665                 670         


Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly 
        675                 680                 685             


Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu 
    690                 695                 700                 


Arg His Asp 
705         


<210>  20
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CM005G08-hFerr

<400>  20

Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val 
1               5                   10                  15      


Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser 
    50                  55                  60                  


Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser 
        275                 280                 285             


Gly Gly Gly Val Glu Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    290                 295                 300                 


Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser Trp Val Arg Gln 
305                 310                 315                 320 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp Asn Gly 
                325                 330                 335     


Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Val Thr Ile Ser 
            340                 345                 350         


Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        355                 360                 365             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ile Leu Gly Ala Gly 
    370                 375                 380                 


Arg Gly Trp Tyr Phe Asp Leu Trp Gly Lys Gly Thr Thr Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr 
    530                 535                 540                 


Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala 
545                 550                 555                 560 


Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val 
                565                 570                 575     


Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys 
            580                 585                 590         


Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly 
        595                 600                 605             


Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly 
    610                 615                 620                 


Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu 
625                 630                 635                 640 


Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp 
                645                 650                 655     


Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val 
            660                 665                 670         


Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg Leu 
        675                 680                 685             


Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr 
    690                 695                 700                 


Leu Arg His Asp 
705             


<210>  21
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CM005G08-hFerr

<400>  21

Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val 
1               5                   10                  15      


Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser 
    50                  55                  60                  


Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser 
        275                 280                 285             


Gly Gly Gly Val Glu Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    290                 295                 300                 


Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser Trp Val Arg Gln 
305                 310                 315                 320 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp Asn Gly 
                325                 330                 335     


Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Val Thr Ile Ser 
            340                 345                 350         


Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        355                 360                 365             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ile Leu Gly Ala Gly 
    370                 375                 380                 


Arg Gly Trp Tyr Phe Asp Leu Trp Gly Lys Gly Thr Thr Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp 
    530                 535                 540                 


Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser 
545                 550                 555                 560 


Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala 
                565                 570                 575     


Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg 
            580                 585                 590         


Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg 
        595                 600                 605             


Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys 
    610                 615                 620                 


Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn 
625                 630                 635                 640 


Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro 
                645                 650                 655     


His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys 
            660                 665                 670         


Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly 
        675                 680                 685             


Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu 
    690                 695                 700                 


Arg His Asp 
705         


<210>  22
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CM059H03-hFerr

<400>  22

Ala Leu Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser 
            20                  25                  30          


Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Ile Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
65                  70                  75                  80  


Leu Glu Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser 
                85                  90                  95      


Ser Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    290                 295                 300                 


Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Gly 
305                 310                 315                 320 


Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                325                 330                 335     


Trp Ile Ser Ala Tyr Asn Gly Lys Thr Asn Tyr Val Gln Glu Leu Gln 
            340                 345                 350         


Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr Met 
        355                 360                 365             


Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
    370                 375                 380                 


Arg Arg Gly Asn Asn Tyr Arg Phe Gly Tyr Phe Asp Phe Trp Gly Gln 
385                 390                 395                 400 


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                405                 410                 415     


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
            420                 425                 430         


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
        435                 440                 445             


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
    450                 455                 460                 


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
465                 470                 475                 480 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
                485                 490                 495     


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
            500                 505                 510         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile 
    530                 535                 540                 


Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val 
545                 550                 555                 560 


Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr 
                565                 570                 575     


Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg 
            580                 585                 590         


Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met 
        595                 600                 605             


Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro 
    610                 615                 620                 


Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met 
625                 630                 635                 640 


Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu 
                645                 650                 655     


Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His 
            660                 665                 670         


Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu 
        675                 680                 685             


Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr 
    690                 695                 700                 


Leu Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710                 


<210>  23
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CM059H03-hFerr

<400>  23

Ala Leu Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser 
            20                  25                  30          


Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Ile Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
65                  70                  75                  80  


Leu Glu Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser 
                85                  90                  95      


Ser Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    290                 295                 300                 


Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Gly 
305                 310                 315                 320 


Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                325                 330                 335     


Trp Ile Ser Ala Tyr Asn Gly Lys Thr Asn Tyr Val Gln Glu Leu Gln 
            340                 345                 350         


Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr Met 
        355                 360                 365             


Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
    370                 375                 380                 


Arg Arg Gly Asn Asn Tyr Arg Phe Gly Tyr Phe Asp Phe Trp Gly Gln 
385                 390                 395                 400 


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                405                 410                 415     


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
            420                 425                 430         


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
        435                 440                 445             


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
    450                 455                 460                 


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
465                 470                 475                 480 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
                485                 490                 495     


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
            500                 505                 510         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg 
    530                 535                 540                 


Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn 
545                 550                 555                 560 


Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe 
                565                 570                 575     


Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu 
            580                 585                 590         


Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln 
        595                 600                 605             


Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala 
    610                 615                 620                 


Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala 
625                 630                 635                 640 


Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly 
                645                 650                 655     


Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe 
            660                 665                 670         


Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr 
        675                 680                 685             


Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu 
    690                 695                 700                 


Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710             


<210>  24
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CM084A02-hFerr

<400>  24

Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
1               5                   10                  15      


Gln Arg Val Ser Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser 
            20                  25                  30          


Asn Thr Val Ile Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Met Tyr Ser Asn Asp Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly His Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    290                 295                 300                 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Val Asn Tyr Phe 
305                 310                 315                 320 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
                325                 330                 335     


Met Ile Asn Pro Ser Gly Gly Thr Thr Lys Asn Arg Gln Lys Phe Gln 
            340                 345                 350         


Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Arg Thr Val Tyr Met 
        355                 360                 365             


Glu Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    370                 375                 380                 


Thr Asp Phe Lys Gly Thr Asp Ile Leu Phe Arg Asp Trp Gly Arg Gly 
385                 390                 395                 400 


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
                405                 410                 415     


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
            420                 425                 430         


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        435                 440                 445             


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    450                 455                 460                 


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
465                 470                 475                 480 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
                485                 490                 495     


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg 
    530                 535                 540                 


Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn 
545                 550                 555                 560 


Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe 
                565                 570                 575     


Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu 
            580                 585                 590         


Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln 
        595                 600                 605             


Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala 
    610                 615                 620                 


Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala 
625                 630                 635                 640 


Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly 
                645                 650                 655     


Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe 
            660                 665                 670         


Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr 
        675                 680                 685             


Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu 
    690                 695                 700                 


Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710             


<210>  25
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CM084A02-hFerr

<400>  25

Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
1               5                   10                  15      


Gln Arg Val Ser Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser 
            20                  25                  30          


Asn Thr Val Ile Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Met Tyr Ser Asn Asp Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly His Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    290                 295                 300                 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Val Asn Tyr Phe 
305                 310                 315                 320 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
                325                 330                 335     


Met Ile Asn Pro Ser Gly Gly Thr Thr Lys Asn Arg Gln Lys Phe Gln 
            340                 345                 350         


Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Arg Thr Val Tyr Met 
        355                 360                 365             


Glu Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    370                 375                 380                 


Thr Asp Phe Lys Gly Thr Asp Ile Leu Phe Arg Asp Trp Gly Arg Gly 
385                 390                 395                 400 


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
                405                 410                 415     


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
            420                 425                 430         


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        435                 440                 445             


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    450                 455                 460                 


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
465                 470                 475                 480 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
                485                 490                 495     


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln 
    530                 535                 540                 


Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu 
545                 550                 555                 560 


Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp 
                565                 570                 575     


Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu 
            580                 585                 590         


Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn 
        595                 600                 605             


Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu 
    610                 615                 620                 


Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu 
625                 630                 635                 640 


Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser 
                645                 650                 655     


Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu 
            660                 665                 670         


Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn 
        675                 680                 685             


Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe 
    690                 695                 700                 


Glu Arg Leu Thr Leu Arg His Asp 
705                 710         


<210>  26
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014A04-hFerr

<400>  26

Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Thr Ser Asp Val Gly Gly 
            20                  25                  30          


Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Met Ile Tyr Gly Val Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly 
                85                  90                  95      


Ser Asn Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Asp Val Lys Arg Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Val Ser Cys Lys Ile Ser Gly Asp Ser Phe Asn Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Asp Ser Gly Thr Ala Asp Ser Ala Gln Lys Phe His Gly 
            340                 345                 350         


Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Phe Leu Glu 
        355                 360                 365             


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val Arg 
    370                 375                 380                 


Gln His Arg Gly Asn Thr Phe Ala Pro Trp Gly Arg Gly Thr Met Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr 
    530                 535                 540                 


Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu 
545                 550                 555                 560 


Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp 
                565                 570                 575     


Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu 
            580                 585                 590         


Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg 
        595                 600                 605             


Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu 
    610                 615                 620                 


Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys 
625                 630                 635                 640 


Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
                645                 650                 655     


Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
            660                 665                 670         


Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His 
        675                 680                 685             


Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg 
    690                 695                 700                 


Leu Thr Leu Arg His Asp 
705                 710 


<210>  27
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014A04-hFerr

<400>  27

Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Thr Ser Asp Val Gly Gly 
            20                  25                  30          


Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Met Ile Tyr Gly Val Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly 
                85                  90                  95      


Ser Asn Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Asp Val Lys Arg Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Val Ser Cys Lys Ile Ser Gly Asp Ser Phe Asn Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Asp Ser Gly Thr Ala Asp Ser Ala Gln Lys Phe His Gly 
            340                 345                 350         


Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Phe Leu Glu 
        355                 360                 365             


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val Arg 
    370                 375                 380                 


Gln His Arg Gly Asn Thr Phe Ala Pro Trp Gly Arg Gly Thr Met Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser 
    530                 535                 540                 


Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln 
545                 550                 555                 560 


Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp 
                565                 570                 575     


Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu 
            580                 585                 590         


Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly 
        595                 600                 605             


Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp 
    610                 615                 620                 


Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
625                 630                 635                 640 


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
                645                 650                 655     


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
            660                 665                 670         


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
        675                 680                 685             


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
    690                 695                 700                 


Thr Leu Arg His Asp 
705                 


<210>  28
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014G03-hFerr

<400>  28

Ala Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Ala 
            20                  25                  30          


Tyr Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Val Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Gln Thr Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Tyr Gln Gly 
                85                  90                  95      


Tyr Asn Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Met Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Leu Ser Cys Arg Val Ser Gly Asp Thr Phe Thr Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Ile Ser Gly Thr Ala Gly Ser Ala Glu Lys Phe Arg Gly 
            340                 345                 350         


Arg Val Ala Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
        355                 360                 365             


Leu Asn Arg Leu Thr Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Gln His Arg Gly Asn Thr Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr 
    530                 535                 540                 


Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu 
545                 550                 555                 560 


Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp 
                565                 570                 575     


Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu 
            580                 585                 590         


Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg 
        595                 600                 605             


Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu 
    610                 615                 620                 


Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys 
625                 630                 635                 640 


Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
                645                 650                 655     


Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
            660                 665                 670         


Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His 
        675                 680                 685             


Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg 
    690                 695                 700                 


Leu Thr Leu Arg His Asp 
705                 710 


<210>  29
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014G03-hFerr

<400>  29

Ala Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Ala 
            20                  25                  30          


Tyr Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Val Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Gln Thr Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Tyr Gln Gly 
                85                  90                  95      


Tyr Asn Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Met Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Leu Ser Cys Arg Val Ser Gly Asp Thr Phe Thr Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Ile Ser Gly Thr Ala Gly Ser Ala Glu Lys Phe Arg Gly 
            340                 345                 350         


Arg Val Ala Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
        355                 360                 365             


Leu Asn Arg Leu Thr Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Gln His Arg Gly Asn Thr Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr 
    530                 535                 540                 


Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu 
545                 550                 555                 560 


Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp 
                565                 570                 575     


Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu 
            580                 585                 590         


Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg 
        595                 600                 605             


Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu 
    610                 615                 620                 


Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys 
625                 630                 635                 640 


Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
                645                 650                 655     


Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
            660                 665                 670         


Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His 
        675                 680                 685             


Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg 
    690                 695                 700                 


Leu Thr Leu Arg His Asp 
705                 710 


<210>  30
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014A02-hFerr

<400>  30

Ala Leu Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro 
1               5                   10                  15      


Gly Gln Arg Val Thr Ile Ser Cys Ala Gly Ser Ser Ser Asn Ile Gly 
            20                  25                  30          


Gly Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Ala Thr Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp 
                85                  90                  95      


Ser Arg Gly Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        275                 280                 285             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    290                 295                 300                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asp Tyr Tyr 
305                 310                 315                 320 


Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                325                 330                 335     


Ser Ile Asp Tyr Ala Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
            340                 345                 350         


Arg Val Thr Met Thr Ile Asp Lys Ser Lys Lys Gln Phe Pro Leu Lys 
        355                 360                 365             


Ile Asp Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Gln Leu Gly Arg Ile Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
385                 390                 395                 400 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                405                 410                 415     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            420                 425                 430         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        435                 440                 445             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    450                 455                 460                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
465                 470                 475                 480 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                485                 490                 495     


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser 
    530                 535                 540                 


Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln 
545                 550                 555                 560 


Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp 
                565                 570                 575     


Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu 
            580                 585                 590         


Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly 
        595                 600                 605             


Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp 
    610                 615                 620                 


Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
625                 630                 635                 640 


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
                645                 650                 655     


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
            660                 665                 670         


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
        675                 680                 685             


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
    690                 695                 700                 


Thr Leu Arg His Asp 
705                 


<210>  31
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014A02-hFerr

<400>  31

Ala Leu Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro 
1               5                   10                  15      


Gly Gln Arg Val Thr Ile Ser Cys Ala Gly Ser Ser Ser Asn Ile Gly 
            20                  25                  30          


Gly Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Ala Thr Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp 
                85                  90                  95      


Ser Arg Gly Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        275                 280                 285             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    290                 295                 300                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asp Tyr Tyr 
305                 310                 315                 320 


Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                325                 330                 335     


Ser Ile Asp Tyr Ala Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
            340                 345                 350         


Arg Val Thr Met Thr Ile Asp Lys Ser Lys Lys Gln Phe Pro Leu Lys 
        355                 360                 365             


Ile Asp Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Gln Leu Gly Arg Ile Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
385                 390                 395                 400 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                405                 410                 415     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            420                 425                 430         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        435                 440                 445             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    450                 455                 460                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
465                 470                 475                 480 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                485                 490                 495     


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr 
    530                 535                 540                 


Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala 
545                 550                 555                 560 


Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val 
                565                 570                 575     


Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys 
            580                 585                 590         


Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly 
        595                 600                 605             


Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly 
    610                 615                 620                 


Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu 
625                 630                 635                 640 


Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp 
                645                 650                 655     


Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val 
            660                 665                 670         


Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg Leu 
        675                 680                 685             


Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr 
    690                 695                 700                 


Leu Arg His Asp 
705             


<210>  32
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014A12-hFerr

<400>  32

Ala Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Pro Pro Gly 
1               5                   10                  15      


Gln Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Val Gly Gly 
            20                  25                  30          


Tyr Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Ile Ile His Asp Val Ser Arg Arg Pro Ser Glu Val Ser Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Ser Ser Tyr Ser Ser 
                85                  90                  95      


Thr Asn Ser Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Asp Val Lys Arg Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Val Ser Cys Lys Ile Ser Gly Asp Ser Phe Thr Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Asp Ser Gly Thr Ala Asp Ser Ala Gln Lys Phe His Gly 
            340                 345                 350         


Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Phe Leu Glu 
        355                 360                 365             


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val Arg 
    370                 375                 380                 


Gln His Arg Gly Asn Thr Phe Ala Pro Trp Gly Arg Gly Thr Met Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr 
    530                 535                 540                 


Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu 
545                 550                 555                 560 


Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp 
                565                 570                 575     


Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu 
            580                 585                 590         


Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg 
        595                 600                 605             


Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu 
    610                 615                 620                 


Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys 
625                 630                 635                 640 


Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
                645                 650                 655     


Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
            660                 665                 670         


Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His 
        675                 680                 685             


Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg 
    690                 695                 700                 


Leu Thr Leu Arg His Asp 
705                 710 


<210>  33
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014A12-hFerr

<400>  33

Ala Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Pro Pro Gly 
1               5                   10                  15      


Gln Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Val Gly Gly 
            20                  25                  30          


Tyr Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Ile Ile His Asp Val Ser Arg Arg Pro Ser Glu Val Ser Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Ser Ser Tyr Ser Ser 
                85                  90                  95      


Thr Asn Ser Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Asp Val Lys Arg Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Val Ser Cys Lys Ile Ser Gly Asp Ser Phe Thr Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Asp Ser Gly Thr Ala Asp Ser Ala Gln Lys Phe His Gly 
            340                 345                 350         


Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Phe Leu Glu 
        355                 360                 365             


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val Arg 
    370                 375                 380                 


Gln His Arg Gly Asn Thr Phe Ala Pro Trp Gly Arg Gly Thr Met Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser 
    530                 535                 540                 


Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln 
545                 550                 555                 560 


Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp 
                565                 570                 575     


Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu 
            580                 585                 590         


Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly 
        595                 600                 605             


Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp 
    610                 615                 620                 


Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
625                 630                 635                 640 


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
                645                 650                 655     


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
            660                 665                 670         


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
        675                 680                 685             


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
    690                 695                 700                 


Thr Leu Arg His Asp 
705                 


<210>  34
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014B01-hFerr

<400>  34

Ala Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Ala 
            20                  25                  30          


Tyr Asn Tyr Val Ser Trp Phe Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Ile Ile Ser Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Leu Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Ala Gly 
                85                  90                  95      


Ser Asn Ile Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Val Ser Cys Lys Ile Ser Gly Asp Thr Phe Ala Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Asn Ser Gly Thr Ala Asp Ser Ser Gln Lys Phe His Gly 
            340                 345                 350         


Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
        355                 360                 365             


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Gln His Arg Ser Asn Thr Phe Asp Pro Trp Gly Gln Gly Thr Met Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr 
    530                 535                 540                 


Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu 
545                 550                 555                 560 


Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp 
                565                 570                 575     


Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu 
            580                 585                 590         


Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg 
        595                 600                 605             


Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu 
    610                 615                 620                 


Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys 
625                 630                 635                 640 


Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
                645                 650                 655     


Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
            660                 665                 670         


Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His 
        675                 680                 685             


Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg 
    690                 695                 700                 


Leu Thr Leu Arg His Asp 
705                 710 


<210>  35
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014B01-hFerr

<400>  35

Ala Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Ala 
            20                  25                  30          


Tyr Asn Tyr Val Ser Trp Phe Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Ile Ile Ser Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Leu Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Ala Gly 
                85                  90                  95      


Ser Asn Ile Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Val Ser Cys Lys Ile Ser Gly Asp Thr Phe Ala Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Asn Ser Gly Thr Ala Asp Ser Ser Gln Lys Phe His Gly 
            340                 345                 350         


Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
        355                 360                 365             


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Gln His Arg Ser Asn Thr Phe Asp Pro Trp Gly Gln Gly Thr Met Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser 
    530                 535                 540                 


Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln 
545                 550                 555                 560 


Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp 
                565                 570                 575     


Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu 
            580                 585                 590         


Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly 
        595                 600                 605             


Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp 
    610                 615                 620                 


Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
625                 630                 635                 640 


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
                645                 650                 655     


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
            660                 665                 670         


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
        675                 680                 685             


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
    690                 695                 700                 


Thr Leu Arg His Asp 
705                 


<210>  36
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014Bll-hFerr

<400>  36

Ala Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Val Gly Gly 
            20                  25                  30          


Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Met Ile Tyr Glu Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr 
                85                  90                  95      


Ser Asn Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Val Ser Cys Lys Ile Ser Gly Asp Ser Phe Thr Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Leu Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Ile Ser Gly Thr Ala Gly Ser Pro Gln Lys Phe His Gly 
            340                 345                 350         


Arg Val Ala Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
        355                 360                 365             


Leu Thr Arg Leu Ala Ser Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Gln His His Ser Asn Thr Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr 
    530                 535                 540                 


Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu 
545                 550                 555                 560 


Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp 
                565                 570                 575     


Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu 
            580                 585                 590         


Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg 
        595                 600                 605             


Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu 
    610                 615                 620                 


Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys 
625                 630                 635                 640 


Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
                645                 650                 655     


Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
            660                 665                 670         


Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His 
        675                 680                 685             


Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg 
    690                 695                 700                 


Leu Thr Leu Arg His Asp 
705                 710 


<210>  37
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014Bll-hFerr

<400>  37

Ala Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Val Gly Gly 
            20                  25                  30          


Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Met Ile Tyr Glu Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr 
                85                  90                  95      


Ser Asn Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Val Ser Cys Lys Ile Ser Gly Asp Ser Phe Thr Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Leu Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Ile Ser Gly Thr Ala Gly Ser Pro Gln Lys Phe His Gly 
            340                 345                 350         


Arg Val Ala Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
        355                 360                 365             


Leu Thr Arg Leu Ala Ser Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Gln His His Ser Asn Thr Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser 
    530                 535                 540                 


Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln 
545                 550                 555                 560 


Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp 
                565                 570                 575     


Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu 
            580                 585                 590         


Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly 
        595                 600                 605             


Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp 
    610                 615                 620                 


Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
625                 630                 635                 640 


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
                645                 650                 655     


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
            660                 665                 670         


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
        675                 680                 685             


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
    690                 695                 700                 


Thr Leu Arg His Asp 
705                 


<210>  38
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014F08-hFerr

<400>  38

Ala Leu Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly 
            20                  25                  30          


Tyr Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Met Ile Tyr Glu Val Ser Met Arg Pro Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Ala Gly 
                85                  90                  95      


Ser Asn Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Leu Ser Cys Arg Val Ser Gly Asp Thr Phe Thr Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Ile Ser Gly Thr Ala Gly Ser Ala Ala Arg Phe Arg Gly 
            340                 345                 350         


Arg Val Ala Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
        355                 360                 365             


Leu Asn Arg Leu Thr Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Gln His Arg Gly Asn Thr Phe Asp Pro Trp Gly Lys Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr 
    530                 535                 540                 


Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu 
545                 550                 555                 560 


Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp 
                565                 570                 575     


Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu 
            580                 585                 590         


Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg 
        595                 600                 605             


Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu 
    610                 615                 620                 


Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys 
625                 630                 635                 640 


Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
                645                 650                 655     


Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
            660                 665                 670         


Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His 
        675                 680                 685             


Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg 
    690                 695                 700                 


Leu Thr Leu Arg His Asp 
705                 710 


<210>  39
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014F08-hFerr

<400>  39

Ala Leu Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly 
            20                  25                  30          


Tyr Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Met Ile Tyr Glu Val Ser Met Arg Pro Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Ala Gly 
                85                  90                  95      


Ser Asn Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Leu Ser Cys Arg Val Ser Gly Asp Thr Phe Thr Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Ile Ser Gly Thr Ala Gly Ser Ala Ala Arg Phe Arg Gly 
            340                 345                 350         


Arg Val Ala Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
        355                 360                 365             


Leu Asn Arg Leu Thr Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Gln His Arg Gly Asn Thr Phe Asp Pro Trp Gly Lys Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser 
    530                 535                 540                 


Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln 
545                 550                 555                 560 


Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp 
                565                 570                 575     


Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu 
            580                 585                 590         


Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly 
        595                 600                 605             


Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp 
    610                 615                 620                 


Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
625                 630                 635                 640 


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
                645                 650                 655     


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
            660                 665                 670         


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
        675                 680                 685             


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
    690                 695                 700                 


Thr Leu Arg His Asp 
705                 


<210>  40
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014G04-hFerr

<400>  40

Ala Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser 
            20                  25                  30          


Tyr Glu Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Arg 
        35                  40                  45              


Leu Met Ile Ser Glu Val Asn Lys Arg Pro Ser Gly Val Pro Asn Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly 
                85                  90                  95      


Ser Asn Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Asp Val Lys Arg Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Val Ser Cys Lys Ile Ser Gly Asp Ser Phe Thr Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Asp Ser Gly Thr Ala Asp Ser Ala Gln Lys Phe His Gly 
            340                 345                 350         


Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Phe Leu Glu 
        355                 360                 365             


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val Arg 
    370                 375                 380                 


Gln His Arg Gly Asn Thr Phe Ala Pro Trp Gly Arg Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr 
    530                 535                 540                 


Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu 
545                 550                 555                 560 


Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp 
                565                 570                 575     


Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu 
            580                 585                 590         


Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg 
        595                 600                 605             


Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu 
    610                 615                 620                 


Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys 
625                 630                 635                 640 


Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
                645                 650                 655     


Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
            660                 665                 670         


Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His 
        675                 680                 685             


Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg 
    690                 695                 700                 


Leu Thr Leu Arg His Asp 
705                 710 


<210>  41
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1014G04-hFerr

<400>  41

Ala Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser 
            20                  25                  30          


Tyr Glu Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Arg 
        35                  40                  45              


Leu Met Ile Ser Glu Val Asn Lys Arg Pro Ser Gly Val Pro Asn Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly 
                85                  90                  95      


Ser Asn Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Ala Asp Val Lys Arg Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Val Ser Cys Lys Ile Ser Gly Asp Ser Phe Thr Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Asp Ser Gly Thr Ala Asp Ser Ala Gln Lys Phe His Gly 
            340                 345                 350         


Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Phe Leu Glu 
        355                 360                 365             


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val Arg 
    370                 375                 380                 


Gln His Arg Gly Asn Thr Phe Ala Pro Trp Gly Arg Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser 
    530                 535                 540                 


Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln 
545                 550                 555                 560 


Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp 
                565                 570                 575     


Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu 
            580                 585                 590         


Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly 
        595                 600                 605             


Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp 
    610                 615                 620                 


Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
625                 630                 635                 640 


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
                645                 650                 655     


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
            660                 665                 670         


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
        675                 680                 685             


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
    690                 695                 700                 


Thr Leu Arg His Asp 
705                 


<210>  42
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1015A02-hFerr

<400>  42

Ala Gln Ala Val Leu Thr Gln Pro Ser Ser Ala Ser Gly Thr Pro Gly 
1               5                   10                  15      


Gln Arg Val Thr Ile Pro Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly 
            20                  25                  30          


Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ile Gly Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        275                 280                 285             


Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
    290                 295                 300                 


Ser Leu Lys Cys Asn Val Ser Gly Gly Ser Ile Gly Thr Gly Asp Tyr 
305                 310                 315                 320 


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
                325                 330                 335     


Gly Tyr Ile His Ser Ser Gly Ser Thr Tyr Tyr Lys Pro Ser Leu Arg 
            340                 345                 350         


Ser Arg Leu Thr Val Ser Met Asp Thr Ser Arg Asn Gln Phe Ser Leu 
        355                 360                 365             


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Val 
    370                 375                 380                 


Arg Glu Trp Ala Asn Gly Asp His Trp Ser Ala Phe Asp Leu Trp Gly 
385                 390                 395                 400 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
                405                 410                 415     


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
            420                 425                 430         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        435                 440                 445             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    450                 455                 460                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
465                 470                 475                 480 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
                485                 490                 495     


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            500                 505                 510         


Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln 
    530                 535                 540                 


Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu 
545                 550                 555                 560 


Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe 
                565                 570                 575     


Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe 
            580                 585                 590         


Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys 
        595                 600                 605             


Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys 
    610                 615                 620                 


Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala 
625                 630                 635                 640 


Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala 
                645                 650                 655     


Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr 
            660                 665                 670         


His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His 
        675                 680                 685             


Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu 
    690                 695                 700                 


Tyr Leu Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710                 715 


<210>  43
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1015A02-hFerr

<400>  43

Ala Gln Ala Val Leu Thr Gln Pro Ser Ser Ala Ser Gly Thr Pro Gly 
1               5                   10                  15      


Gln Arg Val Thr Ile Pro Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly 
            20                  25                  30          


Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ile Gly Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        275                 280                 285             


Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
    290                 295                 300                 


Ser Leu Lys Cys Asn Val Ser Gly Gly Ser Ile Gly Thr Gly Asp Tyr 
305                 310                 315                 320 


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
                325                 330                 335     


Gly Tyr Ile His Ser Ser Gly Ser Thr Tyr Tyr Lys Pro Ser Leu Arg 
            340                 345                 350         


Ser Arg Leu Thr Val Ser Met Asp Thr Ser Arg Asn Gln Phe Ser Leu 
        355                 360                 365             


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Val 
    370                 375                 380                 


Arg Glu Trp Ala Asn Gly Asp His Trp Ser Ala Phe Asp Leu Trp Gly 
385                 390                 395                 400 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
                405                 410                 415     


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
            420                 425                 430         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        435                 440                 445             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    450                 455                 460                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
465                 470                 475                 480 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
                485                 490                 495     


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            500                 505                 510         


Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile 
    530                 535                 540                 


Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val 
545                 550                 555                 560 


Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr 
                565                 570                 575     


Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg 
            580                 585                 590         


Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met 
        595                 600                 605             


Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro 
    610                 615                 620                 


Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met 
625                 630                 635                 640 


Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu 
                645                 650                 655     


Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His 
            660                 665                 670         


Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu 
        675                 680                 685             


Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr 
    690                 695                 700                 


Leu Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710                 


<210>  44
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1015A07 -hFerr

<400>  44

Ala Gln Ser Ala Leu Thr Gln Pro Ala Ser Met Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly 
            20                  25                  30          


Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Met Ile Tyr Ala Val Thr Asn Arg Pro Ser Gly Val Ser Asn Arg 
    50                  55                  60                  


Phe Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser 
                85                  90                  95      


Ser Asn Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Ala Gln Ser Gly Ala Glu Val Asn Lys Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Val Ser Cys Lys Ile Ser Gly Asp Ser Phe Thr Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Leu Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Ile Ser Gly Thr Ala Asp Ser Pro Gln Lys Phe His Gly 
            340                 345                 350         


Arg Val Ala Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
        355                 360                 365             


Leu Thr Arg Leu Ala Ser Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Gln His His Ser Asn Thr Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr 
    530                 535                 540                 


Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu 
545                 550                 555                 560 


Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp 
                565                 570                 575     


Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu 
            580                 585                 590         


Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg 
        595                 600                 605             


Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu 
    610                 615                 620                 


Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys 
625                 630                 635                 640 


Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
                645                 650                 655     


Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
            660                 665                 670         


Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His 
        675                 680                 685             


Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg 
    690                 695                 700                 


Leu Thr Leu Arg His Asp 
705                 710 


<210>  45
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1015A07 -hFerr

<400>  45

Ala Gln Ser Ala Leu Thr Gln Pro Ala Ser Met Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly 
            20                  25                  30          


Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Met Ile Tyr Ala Val Thr Asn Arg Pro Ser Gly Val Ser Asn Arg 
    50                  55                  60                  


Phe Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser 
                85                  90                  95      


Ser Asn Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Ala Gln Ser Gly Ala Glu Val Asn Lys Pro Gly Ala Ser Val 
    290                 295                 300                 


Lys Val Ser Cys Lys Ile Ser Gly Asp Ser Phe Thr Ala Tyr Phe Ile 
305                 310                 315                 320 


His Trp Leu Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Met Gly Trp 
                325                 330                 335     


Phe Asn Pro Ile Ser Gly Thr Ala Asp Ser Pro Gln Lys Phe His Gly 
            340                 345                 350         


Arg Val Ala Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
        355                 360                 365             


Leu Thr Arg Leu Ala Ser Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Gln His His Ser Asn Thr Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
385                 390                 395                 400 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                405                 410                 415     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            420                 425                 430         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        435                 440                 445             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    450                 455                 460                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                485                 490                 495     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser 
    530                 535                 540                 


Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln 
545                 550                 555                 560 


Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp 
                565                 570                 575     


Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu 
            580                 585                 590         


Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly 
        595                 600                 605             


Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp 
    610                 615                 620                 


Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
625                 630                 635                 640 


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
                645                 650                 655     


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
            660                 665                 670         


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
        675                 680                 685             


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
    690                 695                 700                 


Thr Leu Arg His Asp 
705                 


<210>  46
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1006F07-hFerr

<400>  46

Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly 
1               5                   10                  15      


Gln Ala Ala Arg Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr 
            20                  25                  30          


Ala Ser Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile 
        35                  40                  45              


Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
    50                  55                  60                  


Ser Asn Ser Gly Asn Thr Ala Thr Leu Lys Ile Ser Gly Thr Gln Ala 
65                  70                  75                  80  


Met Asp Glu Ala Asp Tyr Tyr Cys Leu Ala Trp Asp Ser Ser Ala Asp 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 
        275                 280                 285             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    290                 295                 300                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val 
305                 310                 315                 320 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly 
                325                 330                 335     


Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            340                 345                 350         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        355                 360                 365             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Pro Ser 
    370                 375                 380                 


Phe Gln Gln Trp Gly His Tyr Ser Tyr Gly Met Asp Val Trp Gly Gln 
385                 390                 395                 400 


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                405                 410                 415     


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
            420                 425                 430         


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
        435                 440                 445             


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
    450                 455                 460                 


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
465                 470                 475                 480 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
                485                 490                 495     


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
            500                 505                 510         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile 
    530                 535                 540                 


Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val 
545                 550                 555                 560 


Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr 
                565                 570                 575     


Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg 
            580                 585                 590         


Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met 
        595                 600                 605             


Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro 
    610                 615                 620                 


Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met 
625                 630                 635                 640 


Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu 
                645                 650                 655     


Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His 
            660                 665                 670         


Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu 
        675                 680                 685             


Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr 
    690                 695                 700                 


Leu Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710                 


<210>  47
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1006F07-hFerr

<400>  47

Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly 
1               5                   10                  15      


Gln Ala Ala Arg Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr 
            20                  25                  30          


Ala Ser Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile 
        35                  40                  45              


Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
    50                  55                  60                  


Ser Asn Ser Gly Asn Thr Ala Thr Leu Lys Ile Ser Gly Thr Gln Ala 
65                  70                  75                  80  


Met Asp Glu Ala Asp Tyr Tyr Cys Leu Ala Trp Asp Ser Ser Ala Asp 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 
        275                 280                 285             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    290                 295                 300                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val 
305                 310                 315                 320 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly 
                325                 330                 335     


Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            340                 345                 350         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        355                 360                 365             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Pro Ser 
    370                 375                 380                 


Phe Gln Gln Trp Gly His Tyr Ser Tyr Gly Met Asp Val Trp Gly Gln 
385                 390                 395                 400 


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                405                 410                 415     


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
            420                 425                 430         


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
        435                 440                 445             


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
    450                 455                 460                 


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
465                 470                 475                 480 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
                485                 490                 495     


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
            500                 505                 510         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg 
    530                 535                 540                 


Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn 
545                 550                 555                 560 


Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe 
                565                 570                 575     


Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu 
            580                 585                 590         


Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln 
        595                 600                 605             


Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala 
    610                 615                 620                 


Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala 
625                 630                 635                 640 


Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly 
                645                 650                 655     


Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe 
            660                 665                 670         


Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr 
        675                 680                 685             


Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu 
    690                 695                 700                 


Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710             


<210>  48
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  42/43-hFerr

<400>  48

Leu Glu Asp Ile Gln Met Ile Gln Ser Pro Leu Ser Leu Pro Val Ile 
1               5                   10                  15      


Pro Gly Glu Pro Ala Ser Met Ser Cys Arg Ser Ser Arg Ser Leu Leu 
            20                  25                  30          


His Ser Asn Gly Asn Asn Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly 
        35                  40                  45              


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met 
                85                  90                  95      


Gln Gly Leu Gln Leu Pro Thr Thr Phe Gly Gly Thr Lys Val Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    290                 295                 300                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn 
305                 310                 315                 320 


Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                325                 330                 335     


Met Gly Ile Ser Ala Tyr Thr Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
            340                 345                 350         


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
        355                 360                 365             


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
    370                 375                 380                 


Val Arg Asp Tyr His Asp Ser Asn Gly Tyr Tyr Tyr Phe Asp Tyr Trp 
385                 390                 395                 400 


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ser Thr Lys Gly Pro Ser 
                405                 410                 415     


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
            420                 425                 430         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        435                 440                 445             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    450                 455                 460                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
465                 470                 475                 480 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
                485                 490                 495     


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            500                 505                 510         


Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln 
    530                 535                 540                 


Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu 
545                 550                 555                 560 


Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe 
                565                 570                 575     


Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe 
            580                 585                 590         


Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys 
        595                 600                 605             


Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys 
    610                 615                 620                 


Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala 
625                 630                 635                 640 


Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala 
                645                 650                 655     


Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr 
            660                 665                 670         


His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His 
        675                 680                 685             


Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu 
    690                 695                 700                 


Tyr Leu Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710                 715 


<210>  49
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  42/43-hFerr

<400>  49

Leu Glu Asp Ile Gln Met Ile Gln Ser Pro Leu Ser Leu Pro Val Ile 
1               5                   10                  15      


Pro Gly Glu Pro Ala Ser Met Ser Cys Arg Ser Ser Arg Ser Leu Leu 
            20                  25                  30          


His Ser Asn Gly Asn Asn Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly 
        35                  40                  45              


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met 
                85                  90                  95      


Gln Gly Leu Gln Leu Pro Thr Thr Phe Gly Gly Thr Lys Val Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    290                 295                 300                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn 
305                 310                 315                 320 


Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                325                 330                 335     


Met Gly Ile Ser Ala Tyr Thr Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
            340                 345                 350         


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
        355                 360                 365             


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
    370                 375                 380                 


Val Arg Asp Tyr His Asp Ser Asn Gly Tyr Tyr Tyr Phe Asp Tyr Trp 
385                 390                 395                 400 


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ser Thr Lys Gly Pro Ser 
                405                 410                 415     


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
            420                 425                 430         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        435                 440                 445             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    450                 455                 460                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
465                 470                 475                 480 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
                485                 490                 495     


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            500                 505                 510         


Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile 
    530                 535                 540                 


Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val 
545                 550                 555                 560 


Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr 
                565                 570                 575     


Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg 
            580                 585                 590         


Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met 
        595                 600                 605             


Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro 
    610                 615                 620                 


Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met 
625                 630                 635                 640 


Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu 
                645                 650                 655     


Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His 
            660                 665                 670         


Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu 
        675                 680                 685             


Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr 
    690                 695                 700                 


Leu Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710                 


<210>  50
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  44/45-hFerr

<400>  50

Leu Glu Glu Ile Val Leu Thr Gln Ser Pro Phe Phe Gln Ser Val Thr 
1               5                   10                  15      


Pro Lys Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly 
            20                  25                  30          


Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Lys Ser Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu 
65                  70                  75                  80  


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Ser Leu 
                85                  90                  95      


Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
    290                 295                 300                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr Gly Met 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val 
                325                 330                 335     


Leu Trp Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly 
            340                 345                 350         


Arg Phe Ala Ile Ser Arg Asp Asn Ser Asn Asn Thr Leu Tyr Leu Gln 
        355                 360                 365             


Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Asp Gly Ser Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Val Gly Gly 
385                 390                 395                 400 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
                405                 410                 415     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            420                 425                 430         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        435                 440                 445             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    450                 455                 460                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
465                 470                 475                 480 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                485                 490                 495     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            500                 505                 510         


Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala 
545                 550                 555                 560 


Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr 
                565                 570                 575     


Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly 
            580                 585                 590         


Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr 
        595                 600                 605             


Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe 
    610                 615                 620                 


Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp 
625                 630                 635                 640 


Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu 
                645                 650                 655     


Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys 
            660                 665                 670         


Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys 
        675                 680                 685             


Lys Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu 
    690                 695                 700                 


Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710                 715                 720 


<210>  51
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  44/45-hFerr

<400>  51

Leu Glu Glu Ile Val Leu Thr Gln Ser Pro Phe Phe Gln Ser Val Thr 
1               5                   10                  15      


Pro Lys Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly 
            20                  25                  30          


Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Lys Ser Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu 
65                  70                  75                  80  


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Ser Leu 
                85                  90                  95      


Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        275                 280                 285             


Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
    290                 295                 300                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr Gly Met 
305                 310                 315                 320 


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val 
                325                 330                 335     


Leu Trp Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly 
            340                 345                 350         


Arg Phe Ala Ile Ser Arg Asp Asn Ser Asn Asn Thr Leu Tyr Leu Gln 
        355                 360                 365             


Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Asp Gly Ser Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Val Gly Gly 
385                 390                 395                 400 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
                405                 410                 415     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            420                 425                 430         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        435                 440                 445             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    450                 455                 460                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
465                 470                 475                 480 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                485                 490                 495     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            500                 505                 510         


Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
545                 550                 555                 560 


Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
                565                 570                 575     


Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
            580                 585                 590         


Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
        595                 600                 605             


Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
    610                 615                 620                 


Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
625                 630                 635                 640 


Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
                645                 650                 655     


Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp 
            660                 665                 670         


Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
        675                 680                 685             


Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala 
    690                 695                 700                 


Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710                 715                 


<210>  52
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46/47-hFerr

<400>  52

Leu Glu Glu Val Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
1               5                   10                  15      


Leu Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
            20                  25                  30          


Ser Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu 
                85                  90                  95      


Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        275                 280                 285             


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
    290                 295                 300                 


Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Ser Gly Ile His 
305                 310                 315                 320 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Val Val Met 
                325                 330                 335     


Trp Tyr Ala Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            340                 345                 350         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        355                 360                 365             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 
    370                 375                 380                 


Gln Gly Val Leu Leu Arg Phe Gly Glu Leu Arg Gly Tyr Tyr Gly Met 
385                 390                 395                 400 


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
                405                 410                 415     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            420                 425                 430         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        435                 440                 445             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    450                 455                 460                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
465                 470                 475                 480 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                485                 490                 495     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            500                 505                 510         


Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    530                 535                 540                 


Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
545                 550                 555                 560 


Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
                565                 570                 575     


Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
            580                 585                 590         


Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
        595                 600                 605             


Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
    610                 615                 620                 


Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
625                 630                 635                 640 


Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
                645                 650                 655     


Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp 
            660                 665                 670         


Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
        675                 680                 685             


Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala 
    690                 695                 700                 


Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710                 715                 


<210>  53
<211>  718
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46/47-hFerr

<400>  53

Leu Glu Glu Val Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
1               5                   10                  15      


Leu Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
            20                  25                  30          


Ser Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu 
                85                  90                  95      


Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        275                 280                 285             


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
    290                 295                 300                 


Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Ser Gly Ile His 
305                 310                 315                 320 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Val Val Met 
                325                 330                 335     


Trp Tyr Ala Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            340                 345                 350         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        355                 360                 365             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 
    370                 375                 380                 


Gln Gly Val Leu Leu Arg Phe Gly Glu Leu Arg Gly Tyr Tyr Gly Met 
385                 390                 395                 400 


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
                405                 410                 415     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            420                 425                 430         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        435                 440                 445             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    450                 455                 460                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
465                 470                 475                 480 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                485                 490                 495     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            500                 505                 510         


Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    530                 535                 540                 


Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val 
545                 550                 555                 560 


Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser 
                565                 570                 575     


Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser 
            580                 585                 590         


His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg 
        595                 600                 605             


Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp 
    610                 615                 620                 


Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met 
625                 630                 635                 640 


Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp 
                645                 650                 655     


Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe 
            660                 665                 670         


Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met 
        675                 680                 685             


Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly 
    690                 695                 700                 


Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Arg His Asp 
705                 710                 715             


<210>  54
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hFerr LALAP I253A

<400>  54

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ala Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro 
    290                 295                 300                 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
305                 310                 315                 320 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ala Ser Arg Thr Pro Glu Val 
                325                 330                 335     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            340                 345                 350         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        355                 360                 365             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    370                 375                 380                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
385                 390                 395                 400 


Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                405                 410                 415     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            420                 425                 430         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        435                 440                 445             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    450                 455                 460                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
465                 470                 475                 480 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                485                 490                 495     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            500                 505                 510         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Gly Ser Gly Gly Met Ser Ser Gln Ile Arg Gln Asn Tyr 
545                 550                 555                 560 


Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu 
                565                 570                 575     


Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp 
            580                 585                 590         


Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu 
        595                 600                 605             


Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg 
    610                 615                 620                 


Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu 
625                 630                 635                 640 


Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys 
                645                 650                 655     


Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
            660                 665                 670         


Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
        675                 680                 685             


Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His 
    690                 695                 700                 


Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg 
705                 710                 715                 720 


Leu Thr Leu Arg His Asp 
                725     


<210>  55
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-hFerr LALAP I253A

<400>  55

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ala Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro 
    290                 295                 300                 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
305                 310                 315                 320 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ala Ser Arg Thr Pro Glu Val 
                325                 330                 335     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            340                 345                 350         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        355                 360                 365             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    370                 375                 380                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
385                 390                 395                 400 


Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                405                 410                 415     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            420                 425                 430         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        435                 440                 445             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    450                 455                 460                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
465                 470                 475                 480 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                485                 490                 495     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            500                 505                 510         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Gly Ser Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser 
545                 550                 555                 560 


Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln 
                565                 570                 575     


Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp 
            580                 585                 590         


Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu 
        595                 600                 605             


Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly 
    610                 615                 620                 


Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp 
625                 630                 635                 640 


Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
                645                 650                 655     


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
            660                 665                 670         


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
        675                 680                 685             


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
    690                 695                 700                 


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
705                 710                 715                 720 


Thr Leu Arg His Asp 
                725 


<210>  56
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hFTL

<400>  56

Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      


Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          


Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              


Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  


Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  


Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      


Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         


Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp 
        115                 120                 125             


Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
    130                 135                 140                 


Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala 
145                 150                 155                 160 


Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Arg His Asp 
                165                 170                 175 


<210>  57
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N_hFTL

<400>  57

Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      


Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          


Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              


Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  


Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  


Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp 
                85                  90  


<210>  58
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C_hFTL

<400>  58

Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
1               5                   10                  15      


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
            20                  25                  30          


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
        35                  40                  45              


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
    50                  55                  60                  


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
65                  70                  75                  80  


Thr Leu Arg His Asp 
                85  


<210>  59
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc

<400>  59

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  60
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 scFc

<400>  60

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro 
    290                 295                 300                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
305                 310                 315                 320 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                325                 330                 335     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            340                 345                 350         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        355                 360                 365             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    370                 375                 380                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
385                 390                 395                 400 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                405                 410                 415     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            420                 425                 430         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        435                 440                 445             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    450                 455                 460                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
465                 470                 475                 480 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                485                 490                 495     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            500                 505                 510         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520                 


<210>  61
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cona LC

<400>  61

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  62
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cona HC

<400>  62

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Phe Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile His Asn Ser Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Gly Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  63
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cona scFab

<400>  63

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
        275                 280                 285             


Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser 
    290                 295                 300                 


Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly Asp Tyr Phe 
305                 310                 315                 320 


Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                325                 330                 335     


His Ile His Asn Ser Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
            340                 345                 350         


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Gln Phe Ser Leu Arg 
        355                 360                 365             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    370                 375                 380                 


Asp Arg Gly Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
385                 390                 395                 400 


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
                405                 410                 415     


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
            420                 425                 430         


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        435                 440                 445             


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    450                 455                 460                 


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
465                 470                 475                 480 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
                485                 490                 495     


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            500                 505                 510 


