﻿                         序列表

<110>  南京北恒生物科技有限公司

<120>  靶向Claudin18.2的抗体及其用途

<130>  BHPCT20

<160>  52

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CDR-L1


<400>  1
Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          

<210>  2
<211>  3
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CDR-L2


<400>  2
Trp Ala Ser 
1           

<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CDR-L3


<400>  3
Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   

<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CDR-H1


<400>  4
Gly Tyr Ser Phe Thr Gly Tyr 
1               5           

<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CDR-H2


<400>  5
Asn Pro Tyr Asn Gly Gly 
1               5       

<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CDR-H3


<400>  6
Met Asn Tyr Gly Asn Ala Met Asp Tyr 
1               5                   

<210>  7
<211>  113
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232 VL


<400>  7
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys 
    

<210>  8
<211>  118
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232 VH


<400>  8
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          
Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              
Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Met Asn Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

<210>  9
<211>  249
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232 scFv


<400>  9
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
        115                 120                 125             
Thr Lys Gly Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
    130                 135                 140                 
Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 
Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu 
                165                 170                 175     
Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn 
            180                 185                 190         
Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             
Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Ala Arg Met Asn Tyr Gly Asn Ala Met Asp Tyr Trp Gly 
225                 230                 235                 240 
Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 

<210>  10
<211>  113
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V1 VL


<400>  10
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys 
    

<210>  11
<211>  118
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V1 VH


<400>  11
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          
Thr Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Met Asn Tyr Gly Asn Ala Met Asp Tyr Trp Gly Ala Gly Thr 
            100                 105                 110         
Thr Val Thr Val Pro Ser 
        115             

<210>  12
<211>  249
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V1 scFv


<400>  12
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
        115                 120                 125             
Thr Lys Gly Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 
Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     
Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Ala 
            180                 185                 190         
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
        195                 200                 205             
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Ala Arg Met Asn Tyr Gly Asn Ala Met Asp Tyr Trp Gly 
225                 230                 235                 240 
Ala Gly Thr Thr Val Thr Val Pro Ser 
                245                 

<210>  13
<211>  113
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V2 VL


<400>  13
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys 
    

<210>  14
<211>  118
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V2 VH


<400>  14
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          
Thr Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Met Asn Tyr Gly Asn Ala Met Asp Tyr Trp Gly Ala Gly Thr 
            100                 105                 110         
Thr Val Thr Val Pro Ser 
        115             

<210>  15
<211>  249
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V2 scFv


<400>  15
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
        115                 120                 125             
Thr Lys Gly Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 
Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     
Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn 
            180                 185                 190         
Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Ser Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Ala Arg Met Asn Tyr Gly Asn Ala Met Asp Tyr Trp Gly 
225                 230                 235                 240 
Ala Gly Thr Thr Val Thr Val Pro Ser 
                245                 

<210>  16
<211>  113
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V3 VL


<400>  16
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys 
    

<210>  17
<211>  118
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V3 VH


<400>  17
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          
Thr Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Met Asn Tyr Gly Asn Ala Met Asp Tyr Trp Gly Ala Gly Thr 
            100                 105                 110         
Thr Val Thr Val Pro Ser 
        115             

<210>  18
<211>  249
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V3 scFv


<400>  18
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
        115                 120                 125             
Thr Lys Gly Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 
Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     
Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn 
            180                 185                 190         
Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Ser Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Ala Arg Met Asn Tyr Gly Asn Ala Met Asp Tyr Trp Gly 
225                 230                 235                 240 
Ala Gly Thr Thr Val Thr Val Pro Ser 
                245                 

<210>  19
<211>  113
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V4 VL


<400>  19
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys 
    

<210>  20
<211>  118
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V4 VH


<400>  20
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          
Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              
Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Leu Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Met Asn Tyr Gly Asn Ala Met Asp Tyr Trp Gly Ala Gly Thr 
            100                 105                 110         
Thr Val Thr Val Pro Ser 
        115             

<210>  21
<211>  249
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V4 scFv


<400>  21
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
        115                 120                 125             
Thr Lys Gly Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 
Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu 
                165                 170                 175     
Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Ala 
            180                 185                 190         
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Ser Ser 
        195                 200                 205             
Thr Ala Tyr Met Glu Leu Leu Ser Leu Arg Ser Asp Asp Thr Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Ala Arg Met Asn Tyr Gly Asn Ala Met Asp Tyr Trp Gly 
225                 230                 235                 240 
Ala Gly Thr Thr Val Thr Val Pro Ser 
                245                 

<210>  22
<211>  113
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V5 VL


<400>  22
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys 
    

<210>  23
<211>  118
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V5 VH


<400>  23
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          
Thr Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Met Asn Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

<210>  24
<211>  249
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V5 scFv


<400>  24
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
        115                 120                 125             
Thr Lys Gly Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 
Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     
Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Ala 
            180                 185                 190         
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
        195                 200                 205             
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Ala Arg Met Asn Tyr Gly Asn Ala Met Asp Tyr Trp Gly 
225                 230                 235                 240 
Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 

<210>  25
<211>  747
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232 scFv


<400>  25
gacattgtga tgacacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact        60
atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttgacc       120
tggtaccagc agaaaccagg gcagcctcct aaactgttga tctactgggc atccactagg       180
gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc       240
atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga ttatagttat       300
ccgctcacgt tcggtgctgg gaccaagctg gagctgaaag gcagcaccag cggcagcggc       360
aaaccgggca gcggcgaagg cagcaccaaa ggcgaggtcc agctgcaaca gtctggacct       420
gagctggtga agcctggagc ttcaatgaag atatcctgca aggcttctgg ttactcattc       480
actggctaca ccatgaactg ggtgaagcag agccatggaa agaaccttga gtggattgga       540
cttattaatc cttacaatgg tggtactagc tacaaccaga agttcaaggg caaggccaca       600
ttaactgtag acaagtcatc cagcacagcc tacatggagc tcctcagtct gacatctgag       660
gactctgcag tctattactg tgcaagaatg aactatggta atgctatgga ctactggggt       720
caaggaacct cagtcaccgt ctcctca                                           747

<210>  26
<211>  747
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V1


<400>  26
gacattgtga tgacacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact        60
atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttgacc       120
tggtaccagc agaaaccagg gcagcctcct aaactgttga tctactgggc atccactagg       180
gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc       240
atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga ttatagttat       300
ccgctcacgt tcggtgctgg gaccaagctg gagctgaaag gcagcaccag cggcagcggc       360
aaaccgggca gcggcgaagg cagcaccaaa ggcgaggtcc agctgcaaca gtctggacct       420
gagctggtga agcctggagc ttcaatgaag atatcctgca aggcttctgg ttactcattc       480
actggctaca ccatgaactg ggtgaagcag agccatggaa agaaccttga gtggattgga       540
cttattaatc cttacaatgg tggtactagc tacaaccaga agttcaaggg caaggccaca       600
ttaactgtag acaagtcatc cagcacagcc tacatggagc tcctcagtct gacatctgag       660
gactctgcag tctattactg tgcaagaatg aactatggta atgctatgga ctactggggt       720
caaggaacct cagtcaccgt ctcctca                                           747

<210>  27
<211>  747
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V2


<400>  27
gatatagtaa tgacacagtc accagacagc ctcgccgtca gcctcggaga gcgagcgaca        60
attaattgta agtcatcaca atcattgttg aacagcggaa atcaaaagaa ttatcttact       120
tggtaccagc aaaaaccagg acagccgcca aaactcctca tttattgggc gagtactcgc       180
gaaagtggtg tcccggaccg cttctccggc tctggaagcg gaactgactt taccctcacc       240
attagcagtc ttcaggcaga agatgtcgca gtgtattact gccaaaatga ctattcatac       300
ccgcttacct ttggcgccgg aaccaaattg gaacttaaag gcagcaccag cggcagcggc       360
aaaccgggca gcggcgaagg cagcaccaaa ggcgaagtcc aactgcagca aagcggtgcg       420
gaggttaaaa aaccaggagc ttctgtaaag gtttcttgca aggcaagtgg ttactctttc       480
actggataca cgatgaattg ggttaagcaa gcgccgggcc agggtctgga atggatcggt       540
ctgataaacc cttacaacgg tggtacatcc tacaaccaaa agttccaagg caaagcaacg       600
cttacggtgg ataagtcatc ttcaactgct tacatggagc tttcccgact ccgatctgaa       660
gactccgccg tgtattactg cgcaaggatg aactatggga acgcgatgga ttactggggg       720
gcaggcacaa cggtgacggt accgagc                                           747

<210>  28
<211>  747
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V3


<400>  28
gatattgtga tgacgcaaag ccctgacagc ctggccgtgt cacttgggga gagagcgaca        60
atgtcttgca agagtagtca gtccctgctg aactctggaa accagaaaaa ttatttgaca       120
tggtatcagc agaaaccagg ccaaccgccc aaattgctga tctattgggc ctcaacccga       180
gagtcaggcg tgccggatcg attctctggc agtggctctg ggactgattt cacccttacc       240
ataagctccg tgcaagcaga ggacgtggcc gtttattatt gtcaaaacga ctactcttat       300
ccacttacat ttggcgctgg cactaaactt gaactgaaag gcagcaccag cggcagcggc       360
aaaccgggca gcggcgaagg cagcaccaaa ggcgaggttc aactccaaca atctggcgcc       420
gaggttaaga agcctggggc gagtgtaaaa gtttcttgta aggcaagtgg ttactctttt       480
accggataca cgatgaattg ggtgaaacaa gcaccgggtc agggtttgga gtggataggg       540
ctcattaatc cgtacaatgg agggacatct tacaatcaga agtttcaagg gaaagcaact       600
ctgactgtcg ataagtcatc tagcaccgcg tacatggagt tgtcacgctt gaggagtgaa       660
gacagtgcgg tgtattattg tgcgcggatg aactatggaa acgcaatgga ctattgggga       720
gctggaacaa cagtgacagt gcctagc                                           747

<210>  29
<211>  747
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V4


<400>  29
gatattgtca tgactcaatc cccagactcc ctcgccgtga gtcttgggga gcgagctacg        60
attaactgta aatcatcaca gagtcttctc aacagtggta atcaaaagaa ttaccttacc       120
tggtatcaac agaagcctgg tcagcctcct aaactcctga tatattgggc atctacgcga       180
gagtctgggg tgccggatag gtttagcgga agtggtagtg gaacagattt cacactcaca       240
ataagctctt tgcaagcgga agatgtagcc gtatactact gccaaaacga ctattcctat       300
cccctgacct ttggagcggg aacgaaactt gagctgaagg gcagcaccag cggcagcggc       360
aaaccgggca gcggcgaagg cagcaccaaa ggcgaagtgc aactgcaaca gtcaggcgcg       420
gaagtaaaga aaccgggggc ctctgtgaaa gtcagctgca aggcctcagg atacagcttt       480
acagggtaca caatgaactg ggtcaaacag agccacggta aaaaccttga gtggataggc       540
ttgataaatc catataatgg aggtacatct tacgcgcaaa agtttcaggg gcgagtaact       600
atgactagag ataaaagctc ctcaacggct tatatggagc tgctgtccct tcgctctgac       660
gataccgccg tatattactg tgctagaatg aactacggta acgctatgga ttattggggg       720
gcagggacga ccgtaactgt tcctagc                                           747

<210>  30
<211>  747
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  BH232_V5


<400>  30
gatattgtta tgacacaaag tcctgattca ctggcggtat ctctcggcga aagggcgaca        60
atcaattgca agtcaagtca aagcctcctt aactcaggaa atcaaaaaaa ctatttgact       120
tggtatcagc agaagccagg acaaccaccg aaactcctta tttattgggc ctccacaagg       180
gagtcaggtg taccagacag gttctcagga agtggctcag gaaccgattt tacccttacc       240
atttcatccc tccaggcgga agacgtggca gtatattact gccagaatga ttactcatat       300
cccctcacct tcggcgcagg gactaagctg gagcttaagg gcagcaccag cggcagcggc       360
aaaccgggca gcggcgaagg cagcaccaaa ggcgaagtcc aacttcagca aagcggagct       420
gaggtcaaaa aacctggcgc aagtgttaaa gtgagctgca aggcaagtgg atatagtttc       480
accggatata cgatgaattg ggtcaaacag gcgcctggac agggactgga atggatagga       540
ctcataaatc cgtacaatgg cggaacaagt tatgcacaga agttccaagg gcgcgtaact       600
atgaccaggg acacctcaat tagcactgct tacatggagc tctcaaggtt gcgatcagac       660
gataccgcgg tttactactg cgccagaatg aattacggca acgcgatgga ctactggggg       720
cagggtacga gcgttactgt ttcaagc                                           747

<210>  31
<211>  25
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α跨膜结构域


<400>  31
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      
Ser Leu Val Ile Thr Leu Tyr Cys Lys 
            20                  25  

<210>  32
<211>  75
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α跨膜结构域


<400>  32
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc        60
accctttact gcaaa                                                         75

<210>  33
<211>  27
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD28跨膜结构域


<400>  33
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          

<210>  34
<211>  81
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD28跨膜结构域


<400>  34
ttttgggtcc tcgtcgtagt tggaggggta cttgcctgtt atagcctcct ggttaccgta        60
gcatttatta tattctgggt g                                                  81

<210>  35
<211>  41
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD28共刺激结构域


<400>  35
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      

<210>  36
<211>  123
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD28共刺激结构域


<400>  36
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc        60
gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc       120
tcc                                                                     123

<210>  37
<211>  40
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  4-1BB共刺激结构域


<400>  37
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
1               5                   10                  15      
Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            20                  25                  30          
Glu Glu Glu Glu Gly Gly Cys Glu 
        35                  40  

<210>  38
<211>  120
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  4-1BB共刺激结构域


<400>  38
cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact        60
actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa       120

<210>  39
<211>  113
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD3ζ信号传导结构域


<400>  39
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         
Arg 
    

<210>  40
<211>  339
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD3ζ信号传导结构域


<400>  40
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag        60
ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt       120
ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac       180
aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag       240
cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac       300
acctacgacg cccttcacat gcaggccctg ccccctcgc                              339

<210>  41
<211>  114
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD3ζ信号传导结构域


<400>  41
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      
Gly Gln Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          
Phe Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              
Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser 
                85                  90                  95      
Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         
Pro Arg 
        

<210>  42
<211>  342
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD3ζ信号传导结构域


<400>  42
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag        60
ctctttaacg agctcaatct aggacgaaga gaggagttcg atgttttgga caagagacgt       120
ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg       180
tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc       240
gagcgccgga ggggcaaggg gcacgatggc cttttccagg gtctcagtac agccaccaag       300
gacacctttg acgcccttca catgcaggcc ctgccccctc gc                          342

<210>  43
<211>  20
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  B2M信号肽


<400>  43
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      
Gly Leu Glu Ala 
            20  

<210>  44
<211>  60
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  B2M信号肽


<400>  44
atgtcccgct ctgttgcttt ggctgtgctg gcccttttgt cccttagcgg actggaggcc        60

<210>  45
<211>  21
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α信号肽


<400>  45
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro 
            20      

<210>  46
<211>  63
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α信号肽


<400>  46
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg        60
ccg                                                                      63

<210>  47
<211>  45
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α铰链区


<400>  47
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  

<210>  48
<211>  135
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α铰链区


<400>  48
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg        60
tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg       120
gacttcgcct gtgat                                                        135

<210>  49
<211>  39
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD28铰链区


<400>  49
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      
Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          
Phe Pro Gly Pro Ser Lys Pro 
        35                  

<210>  50
<211>  117
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD28铰链区


<400>  50
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc        60
catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagccc          117

<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  IgG4铰链区


<400>  51
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          

<210>  52
<211>  36
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  IgG4铰链区


<400>  52
gaaagcaaat acgggccgcc gtgtccaccc tgtccg                                  36

