                        б

<110>  ϺҽҩƼ޹˾

<120> һ־εϸӦ 

<130>  0130-PA-012

<160>  158

<170>  PatentIn version 3.5

<210>  1
<211>  1671
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD19 CDS

<400>  1
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg      960

aggaaaagaa agcgaatgac tgaccccacc aggagattct tcaaagtgac gcctccccca     1020

ggaagcgggc cccagaacca gtacgggaac gtgctgtctc tccccacacc cacctcaggc     1080

ctcggacgcg cccagcgttg ggccgcaggc ctggggggca ctgccccgtc ttatggaaac     1140

ccgagcagcg acgtccaggc ggatggagcc ttggggtccc ggagcccgcc gggagtgggc     1200

ccagaagaag aggaagggga gggctatgag gaacctgaca gtgaggagga ctccgagttc     1260

tatgagaacg actccaacct tgggcaggac cagctctccc aggatggcag cggctacgag     1320

aaccctgagg atgagcccct gggtcctgag gatgaagact ccttctccaa cgctgagtct     1380

tatgagaacg aggatgaaga gctgacccag ccggtcgcca ggacaatgga cttcctgagc     1440

cctcatgggt cagcctggga ccccagccgg gaagcaacct ccctggggtc ccagtcctat     1500

gaggatatga gaggaatcct gtatgcagcc ccccagctcc gctccattcg gggccagcct     1560

ggacccaatc atgaggaaga tgcagactct tatgagaaca tggataatcc cgatgggcca     1620

gacccagcct ggggaggagg gggccgcatg ggcacctgga gcaccaggtg a              1671


<210>  2
<211>  556
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD19 CCDS

<400>  2

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  3
<211>  894
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD20 CDS

<400>  3
atgacaacac ccagaaattc agtaaatggg actttcccgg cagagccaat gaaaggccct       60

attgctatgc aatctggtcc aaaaccactc ttcaggagga tgtcttcact ggtgggcccc      120

acgcaaagct tcttcatgag ggaatctaag actttggggg ctgtccagat tatgaatggg      180

ctcttccaca ttgccctggg gggtcttctg atgatcccag cagggatcta tgcacccatc      240

tgtgtgactg tgtggtaccc tctctgggga ggcattatgt atattatttc cggatcactc      300

ctggcagcaa cggagaaaaa ctccaggaag tgtttggtca aaggaaaaat gataatgaat      360

tcattgagcc tctttgctgc catttctgga atgattcttt caatcatgga catacttaat      420

attaaaattt cccatttttt aaaaatggag agtctgaatt ttattagagc tcacacacca      480

tatattaaca tatacaactg tgaaccagct aatccctctg agaaaaactc cccatctacc      540

caatactgtt acagcataca atctctgttc ttgggcattt tgtcagtgat gctgatcttt      600

gccttcttcc aggaacttgt aatagctggc atcgttgaga atgaatggaa aagaacgtgc      660

tccagaccca aatctaacat agttctcctg tcagcagaag aaaaaaaaga acagactatt      720

gaaataaaag aagaagtggt tgggctaact gaaacatctt cccaaccaaa gaatgaagaa      780

gacattgaaa ttattccaat ccaagaagag gaagaagaag aaacagagac gaactttcca      840

gaacctcccc aagatcagga atcctcacca atagaaaatg acagctctcc ttaa            894


<210>  4
<211>  297
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD20CCDS

<400>  4

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  5
<211>  2280
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD22 CDS

<400>  5
atgcatctcc tcggcccctg gctcctgctc ctggttctag aatacttggc tttctctgac       60

tcaagtaaat gggtttttga gcaccctgaa accctctacg cctgggaggg ggcctgcgtc      120

tggatcccct gcacctacag agccctagat ggtgacctgg aaagcttcat cctgttccac      180

aatcctgagt ataacaagaa cacctcgaag tttgatggga caagactcta tgaaagcaca      240

aaggatggga aggttccttc tgagcagaaa agggtgcaat tcctgggaga caagaataag      300

aactgcacac tgagtatcca cccggtgcac ctcaatgaca gtggtcagct ggggctgagg      360

atggagtcca agactgagaa atggatggaa cgaatacacc tcaatgtctc tgaaaggcct      420

tttccacctc atatccagct ccctccagaa attcaagagt cccaggaagt cactctgacc      480

tgcttgctga atttctcctg ctatgggtat ccgatccaat tgcagtggct cctagagggg      540

gttccaatga ggcaggctgc tgtcacctcg acctccttga ccatcaagtc tgtcttcacc      600

cggagcgagc tcaagttctc cccacagtgg agtcaccatg ggaagattgt gacctgccag      660

cttcaggatg cagatgggaa gttcctctcc aatgacacgg tgcagctgaa cgtgaagcac      720

accccgaagt tggagatcaa ggtcactccc agtgatgcca tagtgaggga gggggactct      780

gtgaccatga cctgcgaggt cagcagcagc aacccggagt acacgacggt atcctggctc      840

aaggatggga cctcgctgaa gaagcagaat acattcacgc taaacctgcg cgaagtgacc      900

aaggaccaga gtgggaagta ctgctgtcag gtctccaatg acgtgggccc gggaaggtcg      960

gaagaagtgt tcctgcaagt gcagtatcct cccaagaagg tgaccacagt gattcaaaac     1020

cccatgccga ttcgagaagg agacacagtg accctttcct gtaactacaa ttccagtaac     1080

cccagtgtta cccggtatga atggaaaccc catggcgcct gggaggagcc atcgcttggg     1140

gtgctgaaga tccaaaacgt tggctgggac aacacaacca tcgcctgcgc agcttgtaat     1200

agttggtgct cgtgggcctc ccctgtcgcc ctgaatgtcc agtatgcccc ccgagacgtg     1260

agggtccgga aaatcaagcc cctttccgag attcactctg gaaactcggt cagcctccaa     1320

tgtgacttct caagcagcca ccccaaagaa gtccagttct tctgggagaa aaatggcagg     1380

cttctgggga aagaaagcca gctgaatttt gactccatct ccccagaaga tgctgggagt     1440

tacagctgct gggtgaacaa ctccatagga cagacagcgt ccaaggcctg gacacttgaa     1500

gtgctgtatg cacccaggag gctgcgtgtg tccatgagcc cgggggacca agtgatggag     1560

gggaagagtg caaccctgac ctgtgagagc gacgccaacc ctcccgtctc ccactacacc     1620

tggtttgact ggaataacca aagcctcccc taccacagcc agaagctgag attggagccg     1680

gtgaaggtcc agcactcggg tgcctactgg tgccagggga ccaacagtgt gggcaagggc     1740

cgttcgcctc tcagcaccct caccgtctac tatagcccgg agaccatcgg caggcgagtg     1800

gctgtgggac tcgggtcctg cctcgccatc ctcatcctgg caatctgtgg gctcaagctc     1860

cagcgacgtt ggaagaggac acagagccag caggggcttc aggagaattc cagcggccag     1920

agcttctttg tgaggaataa aaaggttaga agggcccccc tctctgaagg cccccactcc     1980

ctgggatgct acaatccaat gatggaagat ggcattagct acaccaccct gcgctttccc     2040

gagatgaaca taccacgaac tggagatgca gagtcctcag agatgcagag acctcccccg     2100

gactgcgatg acacggtcac ttattcagca ttgcacaagc gccaagtggg cgactatgag     2160

aacgtcattc cagattttcc agaagatgag gggattcatt actcagagct gatccagttt     2220

ggggtcgggg agcggcctca ggcacaagaa aatgtggact atgtgatcct caaacattga     2280


<210>  6
<211>  759
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD22 CCDS

<400>  6

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Pro Pro Lys Lys Val Thr Thr 
                325                 330                 335     


Val Ile Gln Asn Pro Met Pro Ile Arg Glu Gly Asp Thr Val Thr Leu 
            340                 345                 350         


Ser Cys Asn Tyr Asn Ser Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp 
        355                 360                 365             


Lys Pro His Gly Ala Trp Glu Glu Pro Ser Leu Gly Val Leu Lys Ile 
    370                 375                 380                 


Gln Asn Val Gly Trp Asp Asn Thr Thr Ile Ala Cys Ala Ala Cys Asn 
385                 390                 395                 400 


Ser Trp Cys Ser Trp Ala Ser Pro Val Ala Leu Asn Val Gln Tyr Ala 
                405                 410                 415     


Pro Arg Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His 
            420                 425                 430         


Ser Gly Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro 
        435                 440                 445             


Lys Glu Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys 
    450                 455                 460                 


Glu Ser Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser 
465                 470                 475                 480 


Tyr Ser Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala 
                485                 490                 495     


Trp Thr Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met 
            500                 505                 510         


Ser Pro Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys 
        515                 520                 525             


Glu Ser Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp 
    530                 535                 540                 


Asn Asn Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro 
545                 550                 555                 560 


Val Lys Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser 
                565                 570                 575     


Val Gly Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser 
            580                 585                 590         


Pro Glu Thr Ile Gly Arg Arg Val Ala Val Gly Leu Gly Ser Cys Leu 
        595                 600                 605             


Ala Ile Leu Ile Leu Ala Ile Cys Gly Leu Lys Leu Gln Arg Arg Trp 
    610                 615                 620                 


Lys Arg Thr Gln Ser Gln Gln Gly Leu Gln Glu Asn Ser Ser Gly Gln 
625                 630                 635                 640 


Ser Phe Phe Val Arg Asn Lys Lys Val Arg Arg Ala Pro Leu Ser Glu 
                645                 650                 655     


Gly Pro His Ser Leu Gly Cys Tyr Asn Pro Met Met Glu Asp Gly Ile 
            660                 665                 670         


Ser Tyr Thr Thr Leu Arg Phe Pro Glu Met Asn Ile Pro Arg Thr Gly 
        675                 680                 685             


Asp Ala Glu Ser Ser Glu Met Gln Arg Pro Pro Pro Asp Cys Asp Asp 
    690                 695                 700                 


Thr Val Thr Tyr Ser Ala Leu His Lys Arg Gln Val Gly Asp Tyr Glu 
705                 710                 715                 720 


Asn Val Ile Pro Asp Phe Pro Glu Asp Glu Gly Ile His Tyr Ser Glu 
                725                 730                 735     


Leu Ile Gln Phe Gly Val Gly Glu Arg Pro Gln Ala Gln Glu Asn Val 
            740                 745                 750         


Asp Tyr Val Ile Leu Lys His 
        755                 


<210>  7
<211>  1095
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD33 CDS

<400>  7
atgccgctgc tgctactgct gcccctgctg tgggcagggg ccctggctat ggatccaaat       60

ttctggctgc aagtgcagga gtcagtgacg gtacaggagg gtttgtgcgt cctcgtgccc      120

tgcactttct tccatcccat accctactac gacaagaact ccccagttca tggttactgg      180

ttccgggaag gagccattat atccagggac tctccagtgg ccacaaacaa gctagatcaa      240

gaagtacagg aggagactca gggcagattc cgcctccttg gggatcccag taggaacaac      300

tgctccctga gcatcgtaga cgccaggagg agggataatg gttcatactt ctttcggatg      360

gagagaggaa gtaccaaata cagttacaaa tctccccagc tctctgtgca tgtgacagac      420

ttgacccaca ggcccaaaat cctcatccct ggcactctag aacccggcca ctccaaaaac      480

ctgacctgct ctgtgtcctg ggcctgtgag cagggaacac ccccgatctt ctcctggttg      540

tcagctgccc ccacctccct gggccccagg actactcact cctcggtgct cataatcacc      600

ccacggcccc aggaccacgg caccaacctg acctgtcagg tgaagttcgc tggagctggt      660

gtgactacgg agagaaccat ccagctcaac gtcacctatg ttccacagaa cccaacaact      720

ggtatctttc caggagatgg ctcagggaaa caagagacca gagcaggagt ggttcatggg      780

gccattggag gagctggtgt tacagccctg ctcgctcttt gtctctgcct catcttcttc      840

atagtgaaga cccacaggag gaaagcagcc aggacagcag tgggcaggaa tgacacccac      900

cctaccacag ggtcagcctc cccgaaacac cagaagaagt ccaagttaca tggccccact      960

gaaacctcaa gctgttcagg tgccgcccct actgtggaga tggatgagga gctgcattat     1020

gcttccctca actttcatgg gatgaatcct tccaaggaca cctccaccga atactcagag     1080

gtcaggaccc agtga                                                      1095


<210>  8
<211>  364
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD33 CCDS

<400>  8

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  9
<211>  903
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD38 CDS

<400>  9
atggccaact gcgagttcag cccggtgtcc ggggacaaac cctgctgccg gctctctagg       60

agagcccaac tctgtcttgg cgtcagtatc ctggtcctga tcctcgtcgt ggtgctcgcg      120

gtggtcgtcc cgaggtggcg ccagcagtgg agcggtccgg gcaccaccaa gcgctttccc      180

gagaccgtcc tggcgcgatg cgtcaagtac actgaaattc atcctgagat gagacatgta      240

gactgccaaa gtgtatggga tgctttcaag ggtgcattta tttcaaaaca tccttgcaac      300

attactgaag aagactatca gccactaatg aagttgggaa ctcagaccgt accttgcaac      360

aagattcttc tttggagcag aataaaagat ctggcccatc agttcacaca ggtccagcgg      420

gacatgttca ccctggagga cacgctgcta ggctaccttg ctgatgacct cacatggtgt      480

ggtgaattca acacttccaa aataaactat caatcttgcc cagactggag aaaggactgc      540

agcaacaacc ctgtttcagt attctggaaa acggtttccc gcaggtttgc agaagctgcc      600

tgtgatgtgg tccatgtgat gctcaatgga tcccgcagta aaatctttga caaaaacagc      660

acttttggga gtgtggaagt ccataatttg caaccagaga aggttcagac actagaggcc      720

tgggtgatac atggtggaag agaagattcc agagacttat gccaggatcc caccataaaa      780

gagctggaat cgattataag caaaaggaat attcaatttt cctgcaagaa tatctacaga      840

cctgacaagt ttcttcagtg tgtgaaaaat cctgaggatt catcttgcac atctgagatc      900

tga                                                                    903


<210>  10
<211>  300
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD38 CCDS

<400>  10

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 


<210>  11
<211>  126
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  4-1BB

<400>  11
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  12
<211>  42
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4-1BB

<400>  12

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  13
<211>  66
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  -1

<400>  13
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  14
<211>  63
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  -2

<400>  14
ggaagcggag agggcagagg aagtctgcta acatgcggtg acgtcgagga gaatcctgga       60

cct                                                                     63


<210>  15
<211>  69
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  -3

<400>  15
ggaagcggac agtgtactaa ttatgctctc ttgaaattgg ctggagatgt tgagagcaac       60

cctggacct                                                               69


<210>  16
<211>  75
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  -4

<400>  16
ggaagcggag tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag       60

tccaaccctg gacct                                                        75


<210>  17
<211>  47
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  İ

<400>  17

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          


<210>  18
<211>  336
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD3ƺ

<400>  18
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  19
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD3ư

<400>  19

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  20
<211>  467
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD19ԭCARİУԭ+̼ṹ+CD3ƣ

<400>  20

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Lys Arg Gly Arg Lys Lys Leu 
305                 310                 315                 320 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                325                 330                 335     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            340                 345                 350         


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        355                 360                 365             


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  21
<211>  1404
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD19ԭCARĺУԭ+̼ṹ+CD3ƣ

<400>  21
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatctta aacggggcag aaagaaactc      960

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1020

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1080

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1140

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1200

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg ctaa                                            1404


<210>  22
<211>  121
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  22

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Ile Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Phe Ile Thr Thr Val Leu Asp Phe Asp Tyr Trp Gly 
            100                 105                 110         


His Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  23
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  23

Gly Tyr Ala Phe Ser Ser Ser Trp 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  24

Ile Tyr Pro Gly Asp Gly Asp Thr 
1               5               


<210>  25
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  25

Ala Arg Ser Gly Phe Ile Thr Thr Val Leu Asp Phe Asp Tyr 
1               5                   10                  


<210>  26
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  26

Asp Ile Val Leu Thr Gln Ser Pro Thr Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Phe 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile His Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Ser Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  27
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  27

Glu Ser Val Asp Thr Phe Gly Ile Ser Phe 
1               5                   10  


<210>  28
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  28

Ala Ala Ser 
1           


<210>  29
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  29

Gln Gln Ser Lys Glu Val Pro Phe Thr 
1               5                   


<210>  30
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  30

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  31
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  31

Gly Val Ser Leu Pro Asp Tyr Gly 
1               5               


<210>  32
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  32

Ile Trp Gly Ser Glu Thr Thr 
1               5           


<210>  33
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  33

Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  34
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  34

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  35
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  35

Gln Asp Ile Ser Lys Tyr 
1               5       


<210>  36
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  36

His Thr Ser 
1           


<210>  37
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  37

Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
1               5                   


<210>  38
<211>  121
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  38

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala 
        115                 120     


<210>  39
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  39

Gly Tyr Thr Phe Thr Ser Tyr Asn 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  40

Ile Tyr Pro Gly Asn Gly Asp Thr 
1               5               


<210>  41
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  41

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
1               5                   10                  


<210>  42
<211>  106
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  42

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  43
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  43

Ser Ser Ser Val Ser Tyr 
1               5       


<210>  44
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  44

Ala Thr Ser 
1           


<210>  45
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  45

Gln Gln Trp Thr Ser Asn Pro Pro Thr 
1               5                   


<210>  46
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  46

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  47
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  47

Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
1               5                   10                  15      


<210>  48
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  48

Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser 
1               5                   10                  15      


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro 
                85                  90                  95      


Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  49
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  49

Ala Ser Ser Ser Val Ser Tyr 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  50

Gln Gln Trp Ile Ser Asn Pro Pro Thr 
1               5                   


<210>  51
<211>  121
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  51

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  52
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  52

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  53
<211>  106
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  53

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  54
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  54

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  55
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  55

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala 
1               5                   10  


<210>  56
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  56

Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
1               5                   


<210>  57
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  57

Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp Ile 
1               5                   10                  


<210>  58
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  58

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  59
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  59

Gln Thr Ile Trp Ser Tyr 
1               5       


<210>  60
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  60

Gln Gln Ser Tyr Ser Ile Pro Gln Thr 
1               5                   


<210>  61
<211>  121
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  61

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Gly Asn Asn Tyr Thr Thr Tyr Lys Arg Asn Leu 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Tyr Gly Asn Tyr Gly Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  62
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  62

Gly Tyr Arg Phe Thr Asn Tyr Trp 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  63

Ile Asn Pro Gly Asn Asn Tyr Thr 
1               5               


<210>  64
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  64

Thr Arg Glu Gly Tyr Gly Asn Tyr Gly Ala Trp Phe Ala Tyr 
1               5                   10                  


<210>  65
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  65

Asp Val Val Val Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Phe Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Asn Ser 
            20                  25                  30          


Tyr Gly Asn Thr Phe Leu Ser Trp Tyr Leu His Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Thr Ile Lys Pro Glu Asp Leu Gly Met Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Gln Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  66
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  66

Gln Ser Leu Ala Asn Ser Tyr Gly Asn Thr Phe 
1               5                   10      


<210>  67
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  67

Gly Ile Ser 
1           


<210>  68
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  68

Leu Gln Gly Thr His Gln Pro Tyr Thr 
1               5                   


<210>  69
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  69

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  70
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  70

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  71

Ile Tyr Pro Gly Asn Asp Asp Ile 
1               5               


<210>  72
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  72

Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val 
1               5                   10      


<210>  73
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  73

Asn Ile Met Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe Ser 
            20                  25                  30          


Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ser Glu Asp Leu Ala Ile Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  74
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  74

Gln Ser Val Phe Phe Ser Ser Ser Gln Lys Asn Tyr 
1               5                   10          


<210>  75
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  75

Trp Ala Ser 
1           


<210>  76
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  76

His Gln Tyr Leu Ser Ser Arg Thr 
1               5               


<210>  77
<211>  116
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  77

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  78
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  78

Gly Tyr Thr Ile Thr Asp Ser Asn 
1               5               


<210>  79
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  79

Ile Tyr Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  80
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  80

Val Asn Gly Asn Pro Trp Leu Ala Tyr 
1               5                   


<210>  81
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  81

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu Asp Asn Tyr 
            20                  25                  30          


Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105                 110     


<210>  82
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  82

Glu Ser Leu Asp Asn Tyr Gly Ile Arg Phe 
1               5                   10  


<210>  83
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  83

Gln Gln Thr Lys Glu Val Pro Trp Ser 
1               5                   


<210>  84
<211>  116
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  84

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Asn Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Val Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  85
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  85

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  86
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  86

Ala Arg Gly Arg Pro Ala Met Asp Tyr 
1               5                   


<210>  87
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  87

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  88
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  88

Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10  


<210>  89
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  89

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  90
<211>  116
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  90

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  91
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  91

Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
1               5                   10                  15      


Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Asn Tyr Gly Ile Ser Phe 
            20                  25                  30          


Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  92
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  92

Asn Tyr Gly Ile Ser Phe 
1               5       


<210>  93
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  93

Glu Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Asp Tyr 
            20                  25                  30          


Val Val His Trp Leu Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Arg Tyr Glu Val Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  94
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  94

Gly Tyr Lys Phe Thr Asp Tyr Val 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  95

Ile Asn Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  96
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  96

Ala Arg Asp Tyr Arg Tyr Glu Val Tyr Gly Met Asp Tyr 
1               5                   10              


<210>  97
<211>  106
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  97

Asp Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Asn Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Asp Ser Pro Lys Arg Trp Ile Phe 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Asp Gly Thr Arg Leu Glu Leu Lys 
            100                 105     


<210>  98
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  98

Ala Ser Ser Ser Val Asn Tyr 
1               5           


<210>  99
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  99

Asp Thr Ser 
1           


<210>  100
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  100

Gln Gln Trp Arg Ser Tyr Pro Leu Thr 
1               5                   


<210>  101
<211>  113
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  101

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Lys Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  102
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  102

Gly Ser Ser Phe Thr Gly Tyr Asn 
1               5               


<210>  103
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  103

Ile Asp Pro Tyr Tyr Gly Gly Thr 
1               5               


<210>  104
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  104

Val Ser Gly Met Glu Tyr 
1               5       


<210>  105
<211>  113
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  105

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  106
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  106

Gln Ser Leu Val His Arg Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  107
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  107

Lys Val Ser 
1           


<210>  108
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  108

Ser Gln Ser Thr His Val Pro Pro Leu Thr 
1               5                   10  


<210>  109
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  109

Gln Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Lys Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Lys Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Thr Val Pro Phe Ala Tyr Trp Val Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  110
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  110

Gly Tyr Lys Phe Thr Glu Tyr Thr 
1               5               


<210>  111
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  111

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  112
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  112

Ala Arg Asp Thr Thr Val Pro Phe Ala Tyr 
1               5                   10  


<210>  113
<211>  106
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  113

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Gly Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Val Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Val 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Gln Leu Glu Ile Lys 
            100                 105     


<210>  114
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  114

Gly Ser Ser Ser Ile Ser Tyr 
1               5           


<210>  115
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  115

His Gln Arg Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  116
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  116

Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Leu Gly Glu Leu Asp His Ile Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Ser Ala Ala Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His His Asp Pro Ile Leu Gly Leu Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  117
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  117

Gly Gly Ser Ile Ser Ser Ser Asn Trp 
1               5                   


<210>  118
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  118

Leu Asp His Ile Gly Ser Thr 
1               5           


<210>  119
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  119

Ala Arg His His Asp Pro Ile Leu Gly Leu Asp Ala Phe Asp Ile 
1               5                   10                  15  


<210>  120
<211>  105
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  120

Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
1               5                   10                  15      


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Lys Tyr Leu Asn 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
        35                  40                  45              


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
65                  70                  75                  80  


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp Thr Phe 
                85                  90                  95      


Gly Gln Glu Thr Lys Val Glu Ile Lys 
            100                 105 


<210>  121
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  121

Gln Ser Ile Ser Lys Tyr 
1               5       


<210>  122
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  122

Gln Gln Ser Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  123
<211>  113
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  123

Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  124
<211>  113
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  124

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  125
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  125

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Glu Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Thr Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Thr Thr Ala Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  126
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  126

Gly Tyr Thr Phe Thr Asn Tyr Asp 
1               5               


<210>  127
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  127

Ile Phe Pro Gly Asp Gly Ser Thr 
1               5               


<210>  128
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  128

Ala Arg Gln Thr Thr Ala Thr Trp Phe Ala Tyr 
1               5                   10      


<210>  129
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  129

Asp Ile Glu Leu Thr Gln Ser Pro Thr Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Gln Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Glu Leu Glu Leu Glu 
            100                 105         


<210>  130
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  130

Gln Ser Ile Ser Asp Tyr 
1               5       


<210>  131
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  131

Tyr Ala Ser 
1           


<210>  132
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  132

Gln Asn Gly His Ser Phe Pro Leu Thr 
1               5                   


<210>  133
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  133

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Thr Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Thr Thr Ala Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  134
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  134

Asp Ile Glu Leu Thr Gln Ser Pro Thr Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  135
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  135

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Thr Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Asn Tyr Gly Asn Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  136
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  136

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  137
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  137

Ile Tyr Pro Gly Ser Gly Asn Thr 
1               5               


<210>  138
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  138

Ala Asn Tyr Gly Asn Tyr Trp Phe Ala Tyr 
1               5                   10  


<210>  139
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  139

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  140
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  140

Gln Ser Val Asp Phe Asp Gly Asp Ser Tyr 
1               5                   10  


<210>  141
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  141

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  142
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  142

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Phe Ser Ala 
    50                  55                  60                  


Ser Val Met Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Pro Pro Tyr Gly Asn Pro His Tyr Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  143
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  143

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  144
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  144

Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr 
1               5                   10  


<210>  145
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  145

Ala Arg Asp Pro Pro Tyr Gly Asn Pro His Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15      


<210>  146
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  146

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ala Ser 
            20                  25                  30          


Gly Tyr Asn Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile His Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ser Thr Tyr Tyr Cys Gln His Ser Gly 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  147
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  147

Lys Ser Val Ser Ala Ser Gly Tyr Asn Tyr 
1               5                   10  


<210>  148
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  148

Leu Ala Ser 
1           


<210>  149
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  149

Gln His Ser Gly Glu Leu Pro Phe Thr 
1               5                   


<210>  150
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  150

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  151
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  151

Gly Phe Thr Phe Thr Asp Tyr Thr 
1               5               


<210>  152
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  152

Val Asn Pro Asn Ser Gly Gly Ser 
1               5               


<210>  153
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  153

Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  154
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  154

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  155
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  155

Gln Asp Val Ser Ile Gly 
1               5       


<210>  156
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  156

Ser Ala Ser 
1           


<210>  157
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  157

Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr 
1               5                   

<210>  158
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Խ

<400>  158

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


