                               SEQUENCE LISTING

<110> EMPIRICO INC.
 
<120> TREATMENT OF SOS2 RELATED DISEASES AND DISORDERS

<130> 54462-725.601

<140>
<141>

<150> 63/117,862
<151> 2020-11-24

<160> 14    

<170> PatentIn version 3.5

<210> 1
<211> 5508
<212> DNA
<213> Homo sapiens

<400> 1
agaagcgggc cagcgccgcc gggaaaggag gtcgccgccc ggggtcgccc gggcttgcgg       60

gtcgccgcgc ttcctctgcg ggcgctgcgg gaggcgaggg ccgcctcggc ggaggaagcc      120

gaccccgggg tctccgccag cccgccggcg ccgcctccga gccgcctcgg ccgtagcctc      180

ggcccgggcg ggaggcggcg gccgccggcg aggcgaggcg gcccgcgccc tgcctgtcag      240

gccaccggcc cggcccgcgg gctgcccccg atgcggaggc gctgtcgccg gggccatgca      300

gcaggcgccg cagccttacg agttcttcag cgaggagaac agtccgaaat ggcggggact      360

gttggtctcg gccctgcgga aggttcagga acaagtgcat cccactctct cagctaatga      420

agagtctctc tattatattg aagagctgat ttttcagctg cttaataaat tatgcatggc      480

ccagccaagg actgttcaag atgtagagga gcgagttcag aagacctttc ctcacccaat      540

tgataaatgg gccattgctg atgcacaatc tgctatagaa aaacgaaaac gaagaaatcc      600

tcttttactg cctgtggaca aaatccatcc ttcgttgaag gaagtattag ggtacaaagt      660

ggactaccat gtatccctat atattgtggc tgtactagag tatatctcag ctgatatttt      720

aaaattggct ggtaattatg tttttaatat ccggcattat gaaatatctc agcaggacat      780

taaagtgtca atgtgtgcgg ataaggtttt gatggacatg tttgatcagg atgacatagg      840

tttggtttct ctctgtgaag atgaacctag ttcttctggt gaattaaact actatgatct      900

tgtcagaact gaaatcgcag aagaaagaca gtatctacgg gaattaaata tgatcataaa      960

agtgtttcga gaagcctttc tttctgatag aaagctgttt aaaccttctg atatcgaaaa     1020

gatttttagt aacatttcag atatacatga attgactgtg aaacttttag gtttgattga     1080

agacacagtt gaaatgactg atgaaagcag tcctcatccc ttagctggca gctgttttga     1140

agatttggca gaagagcaag catttgatcc ttatgaaaca ttatcacagg acattctttc     1200

accagagttt catgaacatt tcaataaatt gatggccaga cctgcagttg ctctacactt     1260

tcagtccatt gctgatggtt ttaaagaggc agttcgttat gtccttccac gtcttatgct     1320

ggtgccagtg tatcactgtt ggcactactt tgagttacta aagcaattga aagcatgtag     1380

tgaagaacaa gaagacagag aatgtttgaa ccaagctatt actgctctca tgaatctcca     1440

aggtagcatg gaccgaattt acaagcagta ttcacctaga cgtcgacctg gagatcctgt     1500

ttgccctttt tatagtcacc aattaagaag caaacacctg gctatcaaaa aaatgaatga     1560

aattcagaaa aatatcgatg gatgggaagg caaagatatt ggacagtgtt gtaatgaatt     1620

cattatggag ggaccattga caagaatcgg tgccaaacat gaacggcata tttttctgtt     1680

tgatggctta atgatcagtt gtaaacctaa tcatggccag actcggcttc caggttacag     1740

tagtgcagaa tacaggttaa aagaaaaatt tgtcatgagg aaaatacaaa tttgtgataa     1800

agaagatact tgtgagcaca agcatgcatt tgaattagta tccaaagatg agaacagcat     1860

aatatttgct gctaagtctg ctgaagaaaa aaacaactgg atggcagccc ttatttctct     1920

tcattatcgt agtactctag atcgaatgtt agattcagta ttattgaaag aagaaaatga     1980

gcaaccactg agattaccaa gtcctgaagt atatcgtttt gtagtaaaag actctgagga     2040

aaacattgtt tttgaagaca acttgcaaag tagaagtggc atccccatta ttaaaggagg     2100

aactgtagtg aaattaattg aaaggttaac atatcatatg tatgcagatc ccaattttgt     2160

tcgtactttt cttaccacat atcgttcatt ttgtaaacca caggaattgc tgagcttact     2220

gattgaacgg tttgaaattc cagagccaga acctactgac gcagacaaat tggcaataga     2280

gaaaggcgag cagccaatca gtgcagacct taaaagattt cgcaaggaat atgtccaacc     2340

agtacaactt aggatcttaa atgtatttcg gcattgggtt gaacatcatt tttatgactt     2400

tgaaagagac ttggaattgc ttgaaagact agaatccttc atttcaagtg taagagggaa     2460

agctatgaaa aaatgggtag agtcaattgc taagatcatc aggaggaaga agcaagctca     2520

ggcaaacgga gtaagccata atattacctt tgaaagtcca cctccaccaa ttgaatggca     2580

tatcagcaaa ccaggacagt ttgaaacatt tgatctcatg acacttcatc caatagaaat     2640

tgcacgtcag ctgacacttt tggagtctga tctttacagg aaagttcaac cgtctgaact     2700

tgtagggagt gtgtggacca aagaagataa agaaataaat tctccaaatt tattaaaaat     2760

gattcgccat accacaaatc tcaccctctg gtttgaaaaa tgcattgtgg aagcagaaaa     2820

ttttgaagaa cgggtggcag tactaagtag aattatagaa attctgcaag tttttcaaga     2880

tttgaataat ttcaatggcg tattggagat agtcagtgca gtaaattcag tgtcagtata     2940

cagactagac catacctttg aggcactgca ggaaaggaaa aggaaaattt tggacgaagc     3000

tgtggaatta agtcaagatc actttaaaaa atacctagta aaacttaagt caatcaatcc     3060

accttgtgtg cctttttttg gaatatattt aacaaatatt ctgaagaccg aagaagggaa     3120

taatgatttt ttaaaaaaga aagggaaaga tttaatcaat ttcagtaaga ggaggaaagt     3180

agctgaaatt actggagaaa ttcagcagta tcagaatcag ccttactgtt tacggataga     3240

accagatatg aggagattct ttgaaaacct taaccccatg ggaagtgcat ctgaaaaaga     3300

gtttacagat tatttgttca acaagtcact agaaattgaa cctcgaaact gcaaacagcc     3360

acctcgattt cctaggaaat caactttttc cttaaaatct cctggaataa ggcctaacac     3420

aggccgacat ggctctacct caggtacttt acgaggtcac ccaacaccat tagaaagaga     3480

accatgtaaa ataagcttta gtcggattgc tgaaactgag ctggaatcaa cagtgtcagc     3540

accaacctct ccaaatacac catctactcc accagtatct gcttcttcag accttagtgt     3600

atttttagat gtggatctca acagctcctg tggcagcaat agcatctttg ctccagtgct     3660

tttgccacat tcaaagtctt tctttagttc atgtggtagt ttacataaac taagtgaaga     3720

gcccctgatt cctcctcctc ttcctcctcg aaaaaagttt gatcatgatg cttcaaattc     3780

caagggaaat atgaaatctg atgatgatcc tcctgctatt ccaccgagac agcctcctcc     3840

tccaaaggta aaacccagag ttcctgttcc tactggtgca tttgatgggc ctctgcatag     3900

tccacctccg ccaccaccaa gagatcctct tcctgatacc cctccaccag ttccccttcg     3960

gcctccagaa cactttataa actgtccatt taatcttcag ccacctccac tggggcatct     4020

tcacagagat tcagactggc tcagagacat tagtacgtgt ccaaattcgc caagcactcc     4080

tcctagcaca ccctctccaa gggtaccgcg tcgatgctat gtgctcagtt ctagtcagaa     4140

taatcttgct catcctccag ctccccctgt tccaccaagg cagaattcaa gccctcatct     4200

gccaaaactg ccaccaaaga cttacaaacg ggagctttcg caccccccat tgtacagact     4260

gcctttgcta gaaaatgcag aaactcccca atgaccttag ccatatgtag tcattgacac     4320

tggaatggta tttgtaaagt ttttttttta atttattcaa aaaaagacat agtattttag     4380

tactttttac aaataatgct cttacaaaaa tgctactgat caaataagct tttaagaatt     4440

ggaaaaataa aaatacaaaa gtccttcacc attatcctca ggtgatcagt agcattgcct     4500

tgtcttggat cctcagtgct gccaaaaggc cagtataaag aatttatatt tgcactgtaa     4560

actctgcaaa aatatggttt aaagtgacat gattgcactg aaaagggata gtgcttttgt     4620

gaaatttttc aaatttgagt aatagatgcc tttttaaggc agtgaattta cacaaatatg     4680

ggaggggtat atggtgttac tgatttttaa acctctttga ccatcttcta gtttttactt     4740

ctagttttta catctaggag aattgtgaat aacaccaact gttcttaaac tctttaatgc     4800

catgtcttaa atgccggtat ttgctgctga agacaaaaat gaaaagtagg atgaaaataa     4860

tagaatggca ctgtaagtgt ttattatttt gtcaaaatgt aaacaaagac tacataaccc     4920

aatgatggag ggaaaaaggg catgtatctc attcagatgt gccttttgtt tttgcagact     4980

atgacgtctt tagctaatga attgcctatt gttatggaaa acagttaata tgccatgtat     5040

gtacagtttt gtttatattg tatatttaaa gatactgcta ataacctata taaatttaag     5100

tgacttgagg cctataatac aatctgctac tttactaatt cataaattca aaaaaaattc     5160

tatggcatag gaaccaactg ccttgccttc aagacctagt aactttctct ataaatctcg     5220

tgttaactga aatttttttt aaatatattt tttagattgg taatatttaa accagcaaat     5280

acttaaagct ttattaaaca ttttaatcag ataagtgagt aaagctttta tttgccattt     5340

ggatgccttc gttcaaagtg atagagtgtt ttgctgatag tgctgtagca gcagttgtaa     5400

agtagccaaa agccacgttg tttatttact ggtttgtggc cttttactgt gctttgtatc     5460

agagttctta acaagattaa taaatcaccc cagtcttaat ttttaaaa                  5508


<210> 2
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2' O-methyl modified nucleoside

<400> 2
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 3
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2' O-methyl modified nucleoside

<400> 3
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 4
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2' O-methyl modified nucleoside

<400> 4
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 5
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, u, g, unknown or other

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 5
nnnnnnnnnn nnnnnnnnnn nn                                                22


<210> 6
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, u, g, unknown or other

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 6
nnnnnnnnnn nnnnnnnnnn nn                                                22


<210> 7
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2' O-methyl modified nucleoside

<400> 7
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 8
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2' O-methyl modified nucleoside

<400> 8
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 9
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2' O-methyl modified nucleoside

<400> 9
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 10
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2' O-methyl modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2' O-methyl modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2' O-methyl modified nucleoside

<400> 10
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (7)..(7)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (8)..(8)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (9)..(9)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (10)..(10)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (11)..(11)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (12)..(12)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (13)..(13)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (15)..(15)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2' O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2' O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 11
nnnnnnnnnn nnnnnnnnnn                                                   20


<210> 12
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> D-amino acid

<400> 12
Arg Gly Asp Phe Cys 
1               5   


<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> D-amino acid

<400> 13
Arg Gly Asp Phe Lys 
1               5   


<210> 14
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> D-amino acid

<400> 14
Arg Gly Asp Phe 
1               


