                         SEQUENCE LISTING

<110>  WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
 
<120>  MODULATING TRANSCRIPTIONAL CONDENSATES

<130>  WIBR-173-WO1

<140>  PCT/US2021/060735
<141>  2021-11-24

<150>  US 63/118,586
<151>  2020-11-25

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  1
taatacgact cactataggg                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  2
atttaggtga cactatagaa                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  3
ggcctagaca gcactctcca                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  4
tggatctctg tgagttcaag                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  5
aaatcttgga gagagtagga                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  6
gggaaaaagt tacagtgacc                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  7
cttccagaac atctggattt                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  8
aaaacaaaca aaaaagagtc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  9
agcctgcctt ttggctacca                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  10
agagtgccag gtcccctgga                                                   20


<210>  11
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  11
taggtgagcc gtctttccac c                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  12
cccaattccc ttcactgctg c                                                 21


<210>  13
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  13
cgggcggtga gaagcgt                                                      17


<210>  14
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  14
aatgcatgca caccctctga tt                                                22


<210>  15
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  15
agaggctctt ctggggttgt                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  16
gcgaacaagt agggccagtt                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  17
gccctggatt gtacctgtcc                                                   20


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  18
accttcaaag tgggtaacgc t                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  19
caggttagcc ctaagcgtgc                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  20
aggctagggc acatctgttt                                                   20


<210>  21
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  21
ccctaagcgt gcctagagta t                                                 21


<210>  22
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  22
accaggctag ggcacatct                                                    19


<210>  23
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  23
gctgctgccc tgtctacatt                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  24
ctggccaccc agtactcact                                                   20


<210>  25
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  25
gagtactggg tggccaggt                                                    19


<210>  26
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  26
ccccctctta aaccagcag                                                    19


<210>  27
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  27
gttggagaag gtggaaccaa                                                   20


<210>  28
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  28
cccaattccc ttcactgct                                                    19


<210>  29
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  29
agagggaacc tcctctgagc                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  30
cagccaagtc cctttcactt                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  31
gatctggcac cacaccttct                                                   20


<210>  32
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  32
tggggtgttg aaggtctc                                                     18


<210>  33
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  33
agaattcgag ctcggtac                                                     18


<210>  34
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  34
gcgaattcct agttagctag                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  35
ttgctcacga atacgacggt                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  36
ctgtacatcg gtgtggctgt                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  37
aagaagtgct cgtcctcgtc                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  38
tacgttaaca accccgaggc                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  39
gctcgtagaa ggggaggttg                                                   20


<210>  40
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  40
caccagggca agggtctg                                                     18


<210>  41
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  41
gccctggatt gtacctgtcc                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  42
accttcaaag tgggtaacgc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  43
cctgaagttc atctgcacca                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  44
gtcttgtagg tgccgtcgtc                                                   20


<210>  45
<211>  2268
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  45
agcctgcctt ttggctacca gccacctctt cgctcggatc tttcaccaga gactctcaaa       60

gacactaaag aggcaggaca ggaatggggg ttggggaggg atccatcgcc gtctcctaag      120

cagactcctt tgacccggag ctgtgcgccc tgtaccaaac ctttgtagaa cttggggtaa      180

acttaaggct atggtggcct tgactccgtg gacccagagg caagtttcct cctttagagg      240

actcgcatgc attttgtttc taatttgaaa tgagaaccgg cttagagctt gaaccagcca      300

gttctctgga ctcctcccag ctcttacaat tcctctcccg gacggttcct agaagacaaa      360

ggcaagctta ccaaaattac gtcgcccttg ggacacacct agggttccct ggtggcatct      420

tttttttttc attataaaca ggagtaaatt tttgtaaggg cagagctggt agctgaggga      480

gaggaaccct ttggcctagt gaaggtagtt tgctgggctt tgtatccccg cccccacctc      540

ccccgagaga gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga      600

gagagagaga gagagagact acgtggttat ttcaaaaact tgagtgtggc aaaagtatgt      660

aactgggatt agtaagcatt tctttcctta gtgagattgg agtagagggt gggaaaggac      720

cttagaatcc tcgaatgttg ggcttaggaa tggggagaca agagccatca cagaatgcct      780

attgtccttc aatatgttag cgatgggccc cgtgctttag attttaggct tgtattttct      840

ttgtgtgtgt gtgtgtttgt tttgtttctg tttctttagg cagtctggag atcaggctgg      900

ctttcaactc cctgtgatgc ccctacctct cctgaggtgt gagtggcaga atgctcagcg      960

ggtaaaacac acttgtataa gtgcaagaga accaagttcc aaacattgtc ctctgacttc     1020

ctcaggcatg ccttagctct aacaaataaa attgaagaaa aggattccaa accacggtga     1080

aggtgccaca tctttgatcc ccttaaggca gacagaagta gagggatccc tgggagttca     1140

aagccaggtt ggtctgcata ctgagttggc tagccaggaa tacacactga gactctgtct     1200

ttaaaaaaaa aaaagtgtga agactgcttt ctctgtccca gcacttggga gagagggaaa     1260

gaaacacagc agccagcctt gtctacacag tgagttccag gctaaccaga tctgacatag     1320

tgaggtcctg actcaaaatt aaaaattggc tacagataat actgtagccc ttggttagtc     1380

cgagtactta actcaacata ccattcttcg tttaagcaaa ccacgtgaaa gacttttcac     1440

tgaaggctgc aagtcttaaa atgactttgg tgatgcctgc ctggactgtc taccctctgg     1500

agcagactta caaagaatat tttttactaa gcgctgcata aaccttgata ttttgaacgg     1560

cctattcatt ctttgcctaa tgacaagaat cacatcaggg acatatttgt attagtccag     1620

cgaataagca gaaggtagaa cagttattct tttgttctat gatttctact taggggcttt     1680

agtccatctg tttattgttt aaaaccttca tatctcacca agtagtggtg gccatccctt     1740

taaccccagc attctgagag acagaagcag gtgggtctct gtgagttcga ggccagcctg     1800

gcctacagat ctaattccag gatagccggg gctacataga gaaactctgt ctcaaaataa     1860

ataagtaaat aaataaataa gtaaatgata tatttacatt atttattata tcacaaatta     1920

tatacgtgtt ctatagaata tgttactata tacatatttt ttttggtttt tcgagacagg     1980

gtttcatata gcattagctt catatatata atttatatgc aaaaatatct ctgaaaatgg     2040

aatcactgga acccaattct aaaagtattg tttttttttg tttttaaagt ttcctcatac     2100

ctcaaagttg tcagaggagg gcttaagaga tgggctagag gggctggaga gatagctcag     2160

cagttaagag ctctggttgc tcttccagag gaccagggtt caatttccag tacctacatg     2220

acagctcata actatctgta atttcagttc caggggacct ggcactct                  2268


<210>  46
<211>  594
<212>  DNA
<213>  Artificial

<220>
<223>  47

<400>  46
aaatcttgga gagagtagga cctgagctgt ttcctatttc tactacttcc atagacatcc       60

atgggtctcc tttggttctt accttaaact gcagttctag aggctcttct ggggttgtaa      120

actgcccttc cccaactcag gagctcccat tccctcccct tcctaaactg gccctacttg      180

ttcgctctac tttatcttgc caggggttgt aacagcctcc aatctgtctt ggatcaggaa      240

gcagtttcca tggggtattt taagtgtaag ttccccggtg aaatggaaac aaaaagaata      300

aggtattctg gggacagtgt aggcccacta gggtgtagct tgttttgtaa acacaggacc      360

tgagttttgg actttgccct ggattgtacc tgtcccagtg ggttacctta gatgacacta      420

gcttcataat gcaagaggag gttaagatgc tggctagcgt tacccacttt gaaggtactg      480

gaaaaggaag acctgattta cccaaaagag ggagatctct gtgcttctac cgctttaatt      540

ttttttttct ttttttaaat atttttgcag gactggtcac tgtaactttt tccc            594


<210>  47
<211>  477
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  47
ggcctagaca gcactctcca ccacagttca agtatgcctg cagcccagca gtcctgtctg       60

tattcaatac caaccttgtc ttatggattg tgatttctct tttggtgact cactggccag      120

gacaagagac atattctgag tcctttaact gcctagtgac tggctttgca accaggttag      180

ccctaagcgt gcctagagta taatacagtc cttaacagca actttgtctg aagtcccaag      240

tcttcttaga actagcttga aacagatgtg ccctagcctg gtcccgagct gtgagcctgg      300

tggccctgga gatgggacag cagacctgtt ggctcatctg atccagtttc ttgcctcctg      360

ggtcttagaa aatcatcaga ctaacttttg ggtttgattc aagggttccc tacatagcct      420

tagatggctt ggaactcact ctgtagacca ggctggcctt gaactcacag agatcca         477


<210>  48
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  48
cttccagaac atctggattt gggaagagac gttgctggtc ccagggcggc tgggggttgg       60

ggttggggga gggggatgct aaccagcaag gaagctgttc ctggctgggg caggcctgac      120

tgagctcatg tcgctgaaac tcctcatttc tccctatggc ttcataggga gacccagcct      180

ggatgctaac acgagtgatt tccctgctct agtctagtgt cctccgtgag tccatttaac      240

tgatcaccca gtctgtgagg aggtggctga actcacagta agaaagctgt gggggtcaac      300

gcctattgtt tgtttgtttt gttttagaca aggtctcctg ctgaggctgg ctcaagctgg      360

cctggaggac tcttgtgttt aaggctggcc ttaaattctc tttaaaagaa aatcatgtgt      420

atatatgtgt gtccatgtaa ctgcagatga ccacagcagc caagagattt ctgttctcct      480

agctgtaaac cacccaatat gggtgctagg aacagaattt taaaagggtc ctctgaaaga      540

gcaatgtaca ctcaaatgct gagttctttc ccagccccta gccttggacc tttgttctta      600

tcacttccaa cgcccaaggg caggcattat aggtgtggca ttccgcatct ggcttcccag      660

gatacctttt catgctggtg gaccatctct ggctggggac gtgtgggctt ctctgctgtc      720

tttggttctc cagacagaac tccgagacag atcttgactt ggttctaaaa tacaggtggt      780

ttgtggcaag ttaacgaatt ttagctcaaa tttggggtat ttaagatacc atggtgactc      840

ttttttgttt gtttt                                                       855


<210>  49
<211>  490
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  49
taggtgagcc gtctttccac caggcccccg gctcggggtg cccaccttcc ccatggctgg       60

acacctggct tcagacttcg ccttctcacc cccaccaggt gggggtgatg ggtcagcagg      120

gctggagccg ggctgggtgg atcctcgaac ctggctaagc ttccaagggc ctccaggtgg      180

gcctggaatc ggaccaggct cagaggtatt ggggatctcc ccatgtccgc ccgcatacga      240

gttctgcgga gggatggcat actgtggacc tcaggttgga ctgggcctag tcccccaagt      300

tggcgtggag actttgcagc ctgagggcca ggcaggagca cgagtggaaa gcaactcaga      360

gggaacctcc tctgagccct gtgccgaccg ccccaatgcc gtgaagttgg agaaggtgga      420

accaactccc gaggaggtaa gtgaaaggga cttggctggg ctggcagagg cagcagtgaa      480

gggaattggg                                                             490


<210>  50
<211>  475
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  50
cgggcggtga gaagcgtccg gctgcttcct cagccgcggc ggcctctgca gccgcgtcgt       60

cccctgcggg gggcggtggc gaggcgcagg agcttctgga gcactgcggc gtgtgtcgcg      120

agcgcctgcg gcccgagcgg gatcctcggc tgctgccctg tctacattcg gcctgcagtg      180

cctgcctggg ccccgctaca cccgccgcag cgaataattc gggggatggc ggctcggcgg      240

gcgacggcgc tagtgagtac tgggtggcca ggtgcccctc cccctcctcg cagcccgtgc      300

tcgggactgc gcctgtgcga gagtatgggg gcccgggtag ggttaagtag gcctgctggt      360

ttaagagggg gcggggaacg ggtcctggcc tctgccaatg cccgttacca ggtctggaca      420

ccgaggtgca gaatgtgatg ggagatgtca agaaatcaga gggtgtgcat gcatt           475


<210>  51
<211>  117
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  51
ggttctgccg caggtggatc cggtatgtcc accgccacga cagtcgcccc cgcggggatc       60

ccggcgaccc cgggccctgt gaacccaccc cccccggagg tctccaaccc cagcaag         117


<210>  52
<211>  1000
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  52
atgaccctgc tgattggttc gctgaccatt tccgggtgcg ggacggcgtt accagaaact       60

cagaaggttc gtccaaccaa accgactctg acggcagttt acgagagaga tgatagggtc      120

tgcttcagta agccagatgc tacacaatta ggcttgtaca tattgtcgtt agaacgcggc      180

tacaattaat acataacctt atgtatcata cacatacgat ttaggtgaca ctatagaata      240

caagcttgca tgcctgcagg tcctcggagg acagtactcc gctcggagga cagtactccg      300

ctcggaggac agtactccgc tcggaggaca gtactccgct cggaggacag tactccgact      360

ctagaggatc cccggtgttc ctgaaggggg gctataaaag ggggtggggg cgcgttcgtc      420

ctcactctct tcccctccaa gcaagggcga ggagctgttc accggggtgg tgcccatcct      480

ggtcgagctg gacggcgacg taaacggcca caagttcagc gtgcgcggcg agggcgaggg      540

cgatgccacc aacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt      600

gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca gccgctaccc      660

cgaccacatg aagcagcacg acttcttcaa gtccgccatg cccgaaggct acgtccagga      720

gcgcaccatc tccttcaagg acgacggcac ctacaagacc cgcgccgagg tgaagttcga      780

gggcgacacc ctggtgaacc gcatcgagct gaagggcatc gacttcaagg aggacggcaa      840

catcctgggg cacaagctgg agtacaactt caacagccac aacgtctata tcacggccga      900

caagcagaag aacggcatca aggcgaactt caagatccgc cacaacgtcg aggacggcag      960

cgtgcagctc gccgaccact accagcagaa cacccccatc                           1000


<210>  53
<211>  237
<212>  PRT
<213>  Artificial

<220>
<223>  primer

<400>  53

Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
1               5                   10                  15      


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly 
            20                  25                  30          


Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
        35                  40                  45              


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
    50                  55                  60                  


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
65                  70                  75                  80  


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
                85                  90                  95      


Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys 
            100                 105                 110         


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
        115                 120                 125             


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe 
    130                 135                 140                 


Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile 
145                 150                 155                 160 


Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln 
                165                 170                 175     


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
            180                 185                 190         


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys 
        195                 200                 205             


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
    210                 215                 220                 


Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235         


<210>  54
<211>  626
<212>  PRT
<213>  Artificial

<220>
<223>  primer

<400>  54

Glu His His Ser Gly Ser Gln Gly Pro Leu Leu Thr Thr Gly Asp Leu 
1               5                   10                  15      


Gly Lys Glu Lys Thr Gln Lys Arg Val Lys Glu Gly Asn Gly Thr Ser 
            20                  25                  30          


Asn Ser Thr Leu Ser Gly Pro Gly Leu Asp Ser Lys Pro Gly Lys Arg 
        35                  40                  45              


Ser Arg Thr Pro Ser Asn Asp Gly Lys Ser Lys Asp Lys Pro Pro Lys 
    50                  55                  60                  


Arg Lys Lys Ala Asp Thr Glu Gly Lys Ser Pro Ser His Ser Ser Ser 
65                  70                  75                  80  


Asn Arg Pro Phe Thr Pro Pro Thr Ser Thr Gly Gly Ser Lys Ser Pro 
                85                  90                  95      


Gly Ser Ala Gly Arg Ser Gln Thr Pro Pro Gly Val Ala Thr Pro Pro 
            100                 105                 110         


Ile Pro Lys Ile Thr Ile Gln Ile Pro Lys Gly Thr Val Met Val Gly 
        115                 120                 125             


Lys Pro Ser Ser His Ser Gln Tyr Thr Ser Ser Gly Ser Val Ser Ser 
    130                 135                 140                 


Ser Gly Ser Lys Ser His His Ser His Ser Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Ala Ser Thr Ser Gly Lys Met Lys Ser Ser Lys Ser Glu Gly Ser Ser 
                165                 170                 175     


Ser Ser Lys Leu Ser Ser Ser Met Tyr Ser Ser Gln Gly Ser Ser Gly 
            180                 185                 190         


Ser Ser Gln Ser Lys Asn Ser Ser Gln Ser Gly Gly Lys Pro Gly Ser 
        195                 200                 205             


Ser Pro Ile Thr Lys His Gly Leu Ser Ser Gly Ser Ser Ser Thr Lys 
    210                 215                 220                 


Met Lys Pro Gln Gly Lys Pro Ser Ser Leu Met Asn Pro Ser Leu Ser 
225                 230                 235                 240 


Lys Pro Asn Ile Ser Pro Ser His Ser Arg Pro Pro Gly Gly Ser Asp 
                245                 250                 255     


Lys Leu Ala Ser Pro Met Lys Pro Val Pro Gly Thr Pro Pro Ser Ser 
            260                 265                 270         


Lys Ala Lys Ser Pro Ile Ser Ser Gly Ser Gly Gly Ser His Met Ser 
        275                 280                 285             


Gly Thr Ser Ser Ser Ser Gly Met Lys Ser Ser Ser Gly Leu Gly Ser 
    290                 295                 300                 


Ser Gly Ser Leu Ser Gln Lys Thr Pro Pro Ser Ser Asn Ser Cys Thr 
305                 310                 315                 320 


Ala Ser Ser Ser Ser Phe Ser Ser Ser Gly Ser Ser Met Ser Ser Ser 
                325                 330                 335     


Gln Asn Gln His Gly Ser Ser Lys Gly Lys Ser Pro Ser Arg Asn Lys 
            340                 345                 350         


Lys Pro Ser Leu Thr Ala Val Ile Asp Lys Leu Lys His Gly Val Val 
        355                 360                 365             


Thr Ser Gly Pro Gly Gly Glu Asp Pro Leu Asp Gly Gln Met Gly Val 
    370                 375                 380                 


Ser Thr Asn Ser Ser Ser His Pro Met Ser Ser Lys His Asn Met Ser 
385                 390                 395                 400 


Gly Gly Glu Phe Gln Gly Lys Arg Glu Lys Ser Asp Lys Asp Lys Ser 
                405                 410                 415     


Lys Val Ser Thr Ser Gly Ser Ser Val Asp Ser Ser Lys Lys Thr Ser 
            420                 425                 430         


Glu Ser Lys Asn Val Gly Ser Thr Gly Val Ala Lys Ile Ile Ile Ser 
        435                 440                 445             


Lys His Asp Gly Gly Ser Pro Ser Ile Lys Ala Lys Val Thr Leu Gln 
    450                 455                 460                 


Lys Pro Gly Glu Ser Ser Gly Glu Gly Leu Arg Pro Gln Met Ala Ser 
465                 470                 475                 480 


Ser Lys Asn Tyr Gly Ser Pro Leu Ile Ser Gly Ser Thr Pro Lys His 
                485                 490                 495     


Glu Arg Gly Ser Pro Ser His Ser Lys Ser Pro Ala Tyr Thr Pro Gln 
            500                 505                 510         


Asn Leu Asp Ser Glu Ser Glu Ser Gly Ser Ser Ile Ala Glu Lys Ser 
        515                 520                 525             


Tyr Gln Asn Ser Pro Ser Ser Asp Asp Gly Ile Arg Pro Leu Pro Glu 
    530                 535                 540                 


Tyr Ser Thr Glu Lys His Lys Lys His Lys Lys Glu Lys Lys Lys Val 
545                 550                 555                 560 


Lys Asp Lys Asp Arg Asp Arg Asp Arg Asp Lys Asp Arg Asp Lys Lys 
                565                 570                 575     


Lys Ser His Ser Ile Lys Pro Glu Ser Trp Ser Lys Ser Pro Ile Ser 
            580                 585                 590         


Ser Asp Gln Ser Leu Ser Met Thr Ser Asn Thr Ile Leu Ser Ala Asp 
        595                 600                 605             


Arg Pro Ser Arg Leu Ser Pro Asp Phe Met Ile Gly Glu Glu Asp Asp 
    610                 615                 620                 


Asp Leu 
625     


<210>  55
<211>  627
<212>  PRT
<213>  Artificial

<220>
<223>  primer

<400>  55

Glu Ala Ala Ser Gly Ser Gln Gly Pro Leu Leu Thr Thr Gly Asp Leu 
1               5                   10                  15      


Gly Ala Glu Ala Thr Gln Ala Ala Val Ala Glu Gly Asn Gly Thr Ser 
            20                  25                  30          


Asn Ser Thr Leu Ser Gly Pro Gly Leu Asp Ser Ala Pro Gly Ala Ala 
        35                  40                  45              


Ser Ala Thr Pro Ser Asn Asp Gly Ala Ser Ala Asp Ala Pro Pro Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asp Thr Glu Gly Ala Ser Pro Ser Ala Ser Ser Ser 
65                  70                  75                  80  


Asn Ala Pro Phe Thr Pro Pro Thr Ser Thr Gly Gly Ser Ala Ser Pro 
                85                  90                  95      


Gly Ser Ala Gly Ala Ser Gln Thr Pro Pro Gly Val Ala Thr Pro Pro 
            100                 105                 110         


Ile Pro Ala Ile Thr Ile Gln Ile Pro Ala Gly Thr Val Met Val Gly 
        115                 120                 125             


Ala Pro Ser Ser Ala Ser Gln Tyr Thr Ser Ser Gly Ser Val Ser Ser 
    130                 135                 140                 


Ser Gly Ser Ala Ser Ala Ala Ser Ala Ser Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Ala Ser Thr Ser Gly Ala Met Ala Ser Ser Ala Ser Glu Gly Ser Ser 
                165                 170                 175     


Ser Ser Ala Leu Ser Ser Ser Met Tyr Ser Ser Gln Gly Ser Ser Gly 
            180                 185                 190         


Ser Ser Gln Ser Ala Asn Ser Ser Gln Ser Gly Gly Ala Pro Gly Ser 
        195                 200                 205             


Ser Pro Ile Thr Ala Ala Gly Leu Ser Ser Gly Ser Ser Ser Thr Ala 
    210                 215                 220                 


Met Ala Pro Gln Gly Ala Pro Ser Ser Leu Met Asn Pro Ser Leu Ser 
225                 230                 235                 240 


Ala Pro Asn Ile Ser Pro Ser Ala Ser Ala Pro Pro Gly Gly Ser Asp 
                245                 250                 255     


Ala Leu Ala Ser Pro Met Ala Pro Val Pro Gly Thr Pro Pro Ser Ser 
            260                 265                 270         


Ala Ala Ala Ser Pro Ile Ser Ser Gly Ser Gly Gly Ser Ala Met Ser 
        275                 280                 285             


Gly Thr Ser Ser Ser Ser Gly Met Ala Ser Ser Ser Gly Leu Gly Ser 
    290                 295                 300                 


Ser Gly Ser Leu Ser Gln Ala Thr Pro Pro Ser Ser Asn Ser Cys Thr 
305                 310                 315                 320 


Ala Ser Ser Ser Ser Phe Ser Ser Ser Gly Ser Ser Met Ser Ser Ser 
                325                 330                 335     


Gln Asn Gln Ala Gly Ser Ser Ala Gly Ala Ser Pro Ser Ala Asn Ala 
            340                 345                 350         


Ala Pro Ser Leu Thr Ala Val Ile Asp Ala Leu Ala Ala Gly Val Val 
        355                 360                 365             


Thr Ser Gly Pro Gly Gly Glu Asp Pro Leu Asp Gly Gln Met Gly Val 
    370                 375                 380                 


Ser Thr Asn Ser Ser Ser Ala Pro Met Ser Ser Ala Ala Asn Met Ser 
385                 390                 395                 400 


Gly Gly Glu Phe Gln Gly Ala Ala Glu Ala Ser Asp Ala Asp Ala Ser 
                405                 410                 415     


Ala Val Ser Thr Ser Gly Ser Ser Val Asp Ser Ser Ala Ala Thr Ser 
            420                 425                 430         


Glu Ser Ala Asn Val Gly Ser Thr Gly Val Ala Ala Ile Ile Ile Ser 
        435                 440                 445             


Ala Ala Asp Gly Gly Ser Pro Ser Ile Ala Ala Ala Val Thr Leu Gln 
    450                 455                 460                 


Ala Pro Gly Glu Ser Ser Gly Glu Gly Leu Ala Pro Gln Met Ala Ser 
465                 470                 475                 480 


Ser Ala Asn Tyr Gly Ser Pro Leu Ile Ser Gly Ser Thr Pro Ala Ala 
                485                 490                 495     


Glu Ala Gly Ser Pro Ser Ala Ser Ala Ser Pro Ala Tyr Thr Pro Gln 
            500                 505                 510         


Asn Leu Asp Ser Glu Ser Glu Ser Gly Ser Ser Ile Ala Glu Ala Ser 
        515                 520                 525             


Tyr Gln Asn Ser Pro Ser Ser Asp Asp Gly Ile Ala Pro Leu Pro Glu 
    530                 535                 540                 


Tyr Ser Thr Glu Ala Ala Ala Ala Ala Ala Ala Glu Ala Ala Ala Val 
545                 550                 555                 560 


Ala Asp Ala Asp Ala Asp Ala Asp Ala Asp Ala Asp Ala Asp Ala Ala 
                565                 570                 575     


Ala Ser Ala Ser Ile Ala Pro Glu Ser Trp Ser Ala Ser Pro Ile Ser 
            580                 585                 590         


Ser Asp Gln Ser Leu Ser Met Thr Ser Asn Thr Ile Leu Ser Ala Asp 
        595                 600                 605             


Ala Pro Ser Ala Leu Ser Pro Asp Phe Met Ile Gly Glu Glu Asp Asp 
    610                 615                 620                 


Asp Leu Met 
625         


<210>  56
<211>  678
<212>  PRT
<213>  Artificial

<220>
<223>  primer

<400>  56

Cys Leu Arg Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val Ile 
1               5                   10                  15      


Ala Gly Ser Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu Ser 
            20                  25                  30          


Ser Ser Glu Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Thr Glu Met 
        35                  40                  45              


Ala Pro Lys Ser Lys Lys Lys Gly His Pro Gly Arg Glu Gln Lys Lys 
    50                  55                  60                  


His His His His His His Gln Gln Met Gln Gln Ala Pro Ala Pro Val 
65                  70                  75                  80  


Pro Gln Gln Pro Pro Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro Pro 
                85                  90                  95      


Pro Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Ser Met 
            100                 105                 110         


Pro Gln Gln Ala Ala Pro Ala Met Lys Ser Ser Pro Pro Pro Phe Ile 
        115                 120                 125             


Ala Thr Gln Val Pro Val Leu Glu Pro Gln Leu Pro Gly Ser Val Phe 
    130                 135                 140                 


Asp Pro Ile Gly His Phe Thr Gln Pro Ile Leu His Leu Pro Gln Pro 
145                 150                 155                 160 


Glu Leu Pro Pro His Leu Pro Gln Pro Pro Glu His Ser Thr Pro Pro 
                165                 170                 175     


His Leu Asn Gln His Ala Val Val Ser Pro Pro Ala Leu His Asn Ala 
            180                 185                 190         


Leu Pro Gln Gln Pro Ser Arg Pro Ser Asn Arg Ala Ala Ala Leu Pro 
        195                 200                 205             


Pro Lys Pro Ala Arg Pro Pro Ala Val Ser Pro Ala Leu Thr Gln Thr 
    210                 215                 220                 


Pro Leu Leu Pro Gln Pro Pro Met Ala Gln Pro Pro Gln Val Leu Leu 
225                 230                 235                 240 


Glu Asp Glu Glu Pro Pro Ala Pro Pro Leu Thr Ser Met Gln Met Gln 
                245                 250                 255     


Leu Tyr Leu Gln Gln Leu Gln Lys Val Gln Pro Pro Thr Pro Leu Leu 
            260                 265                 270         


Pro Ser Val Lys Val Gln Ser Gln Pro Pro Pro Pro Leu Pro Pro Pro 
        275                 280                 285             


Pro His Pro Ser Val Gln Gln Gln Leu Gln Gln Gln Pro Pro Pro Pro 
    290                 295                 300                 


Pro Pro Pro Gln Pro Gln Pro Pro Pro Gln Gln Gln His Gln Pro Pro 
305                 310                 315                 320 


Pro Arg Pro Val His Leu Gln Pro Met Gln Phe Ser Thr His Ile Gln 
                325                 330                 335     


Gln Pro Pro Pro Pro Gln Gly Gln Gln Pro Pro His Pro Pro Pro Gly 
            340                 345                 350         


Gln Gln Pro Pro Pro Pro Gln Pro Ala Lys Pro Gln Gln Val Ile Gln 
        355                 360                 365             


His His His Ser Pro Arg His His Lys Ser Asp Pro Tyr Ser Thr Gly 
    370                 375                 380                 


His Leu Arg Glu Ala Pro Ser Pro Leu Met Ile His Ser Pro Gln Met 
385                 390                 395                 400 


Ser Gln Phe Gln Ser Leu Thr His Gln Ser Pro Pro Gln Gln Asn Val 
                405                 410                 415     


Gln Pro Lys Lys Gln Glu Leu Arg Ala Ala Ser Val Val Gln Pro Gln 
            420                 425                 430         


Pro Leu Val Val Val Lys Glu Glu Lys Ile His Ser Pro Ile Ile Arg 
        435                 440                 445             


Ser Glu Pro Phe Ser Pro Ser Leu Arg Pro Glu Pro Pro Lys His Pro 
    450                 455                 460                 


Glu Ser Ile Lys Ala Pro Val His Leu Pro Gln Arg Pro Glu Met Lys 
465                 470                 475                 480 


Pro Val Asp Val Gly Arg Pro Val Ile Arg Pro Pro Glu Gln Asn Ala 
                485                 490                 495     


Pro Pro Pro Gly Ala Pro Asp Lys Asp Lys Gln Lys Gln Glu Pro Lys 
            500                 505                 510         


Thr Pro Val Ala Pro Lys Lys Asp Leu Lys Ile Lys Asn Met Gly Ser 
        515                 520                 525             


Trp Ala Ser Leu Val Gln Lys His Pro Thr Thr Pro Ser Ser Thr Ala 
    530                 535                 540                 


Lys Ser Ser Ser Asp Ser Phe Glu Gln Phe Arg Arg Ala Ala Arg Glu 
545                 550                 555                 560 


Lys Glu Glu Arg Glu Lys Ala Leu Lys Ala Gln Ala Glu His Ala Glu 
                565                 570                 575     


Lys Glu Lys Glu Arg Leu Arg Gln Glu Arg Met Arg Ser Arg Glu Asp 
            580                 585                 590         


Glu Asp Ala Leu Glu Gln Ala Arg Arg Ala His Glu Glu Ala Arg Arg 
        595                 600                 605             


Arg Gln Glu Gln Gln Gln Gln Gln Arg Gln Glu Gln Gln Gln Gln Gln 
    610                 615                 620                 


Gln Gln Gln Ala Ala Ala Val Ala Ala Ala Ala Thr Pro Gln Ala Gln 
625                 630                 635                 640 


Ser Ser Gln Pro Gln Ser Met Leu Asp Gln Gln Arg Glu Leu Ala Arg 
                645                 650                 655     


Lys Arg Glu Gln Glu Arg Arg Arg Arg Glu Ala Met Ala Ala Thr Ile 
            660                 665                 670         


Asp Met Asn Phe Gln Ser 
        675             


<210>  57
<211>  360
<212>  PRT
<213>  Artificial

<220>
<223>  primer

<400>  57

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  58
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  primer

<400>  58

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val Ser Pro Glu Phe Pro Gly Ile Trp Ala Pro Pro Thr Asp Val 
145                 150                 155                 160 


Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu Asp Val Ala Met Ala 
                165                 170                 175     


His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Asp Gly 
            180                 185                 190         


Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp Ser Ala Pro Tyr Gly 
        195                 200                 205             


Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln Met Phe Thr Asp Ala 
    210                 215                 220                 


Leu Gly Ile Asp Glu Tyr Gly Gly 
225                 230         


