                               SEQUENCE LISTING

<110> CELLULAR LONGEVITY, INC.
 
<120> LNP AND LIPOSOME COMPOSITIONS FOR LONGEVITY IN MAMMALS AND 
      METHODS OF USING THE SAME

<130> 58989-703.601

<140> PCT/US2021/061092
<141> 2021-11-30

<150> 63/119,546
<151> 2020-11-30

<160> 16    

<170> PatentIn version 3.5

<210> 1
<211> 5361
<212> DNA
<213> Homo sapiens

<400> 1
tttctccttc cctccacggg ccgggtgaga aagtagccgg gggctatccc gacccggcgg       60

ttcttgggga gggggccgaa caagaaaagg gaggagatgg agataacttc cccggattta      120

gcttttttgt ctttgttttt gttctcacca cttccatcgg atgactggag agtaaaaggg      180

aacccggagc ggggtggcga gcagcgcttt gagaaaatgc aggagtgtgt ttggagacgc      240

gtaaagttgc ctttcaagct ctggcctccg ggcacgcgat gctccgcggc gggctgactc      300

agggctgcct tgggcctccc tgccaccctc ctggaaatga tgcaagtcct gactgtcacc      360

tggatccctg cagcccagcc tggaatgcgt ctggattagg ggaaagacga gaaacgacac      420

tccaggtgtt gcacggccca ccaaagcggg aagatagggc agttgctcag accaaatact      480

gtatctagtg cttctgctcc tatcttcaat cgtggggttc tttttaatgc aaagtgtcac      540

aaggccagga attcccatgt gtgctcagtt ggcccacagc atcattgtgc ctaggaaact      600

gcttcaattt atcaagtcct ctgggctggg aatctcactg aattccaaac ggcggaaaga      660

ggaaactttc ccaacccgat gtgggtgtga cgcgagccag gggccccagg gacactgtcc      720

cagagcacac cgtccccctt taacagcaac tggagcttgg attcgctctt atattgtaca      780

gtcctttcga ccattgccct ggagcacccg cacacgcgca cgcatctccg gccgcgctca      840

cacacactca tacacacgca cgcaaacgcg tggccgccgc caggtcggca actttgtccg      900

gcgctcccag cggcgctcgg cttcctcctg tagtagttga gcgcaggccc cgcctcccgg      960

ccgtgttgtc aaaagggccg gggtctcgga ttggtccagc cgccgggaca acacctgctc     1020

gactccttca ttcaagtgac accagagctt ccagggatat ttgaggcacc atccctgcca     1080

ttgccgggca ctcgcggcgc tgctaacggc ctggtcacat gctctccgga gagctacggg     1140

agggcgctgg gtaacctcta tccgagccgc ggccgcgagg aggagggaaa aggcgagcaa     1200

aaaggaagag tgggaggagg aggggaagcg gcgaaggagg aagaggagga ggaggaagag     1260

gggagcacaa aggatccagg tctcccgacg ggaggttaat accaagaacc atgtgtgccg     1320

agcggctggg ccagttcatg accctggctt tggtgttggc cacctttgac ccggcgcggg     1380

ggaccgacgc caccaaccca cccgagggtc cccaagacag gagctcccag cagaaaggcc     1440

gcctgtccct gcagaataca gcggagatcc agcactgttt ggtcaacgct ggcgatgtgg     1500

ggtgtggcgt gtttgaatgt ttcgagaaca actcttgtga gattcggggc ttacatggga     1560

tttgcatgac ttttctgcac aacgctggaa aatttgatgc ccagggcaag tcattcatca     1620

aagacgcctt gaaatgtaag gcccacgctc tgcggcacag gttcggctgc ataagccgga     1680

agtgcccggc catcagggaa atggtgtccc agttgcagcg ggaatgctac ctcaagcacg     1740

acctgtgcgc ggctgcccag gagaacaccc gggtgatagt ggagatgatc catttcaagg     1800

acttgctgct gcacgaaccc tacgtggacc tcgtgaactt gctgctgacc tgtggggagg     1860

aggtgaagga ggccatcacc cacagcgtgc aggttcagtg tgagcagaac tggggaagcc     1920

tgtgctccat cttgagcttc tgcacctcgg ccatccagaa gcctcccacg gcgccccccg     1980

agcgccagcc ccaggtggac agaaccaagc tctccagggc ccaccacggg gaagcaggac     2040

atcacctccc agagcccagc agtagggaga ctggccgagg tgccaagggt gagcgaggta     2100

gcaagagcca cccaaacgcc catgcccgag gcagagtcgg gggccttggg gctcagggac     2160

cttccggaag cagcgagtgg gaagacgaac agtctgagta ttctgatatc cggaggtgaa     2220

atgaaaggcc tggccacgaa atctttcctc cacgccgtcc attttcttat ctatggacat     2280

tccaaaacat ttaccattag agagggggga tgtcacacgc aggattctgt ggggactgtg     2340

gacttcatcg aggtgtgtgt tcgcggaacg gacaggtgag atggagaccc ctggggccgt     2400

ggggtctcag gggtgcctgg tgaattctgc acttacacgt actcaaggga gcgcgcccgc     2460

gttatcctcg tacctttgtc ttctttccat ctgtggagtc agtgggtgtc ggccgctctg     2520

ttgtggggga ggtgaaccag ggaggggcag ggcaaggcag ggcccccaga gctgggccac     2580

acagtgggtg ctgggcctcg ccccgaagct tctggtgcag cagcctctgg tgctgtctcc     2640

gcggaagtca gggcggctgg attccaggac aggagtgaat gtaaaaataa atatcgctta     2700

gaatgcagga gaagggtgga gaggaggcag gggccgaggg ggtgcttggt gccaaactga     2760

aattcagttt cttgtgtggg gccttgcggt tcagagctct tggcgagggt ggagggagga     2820

gtgtcatttc tatgtgtaat ttctgagcca ttgtactgtc tgggctgggg gggacactgt     2880

ccaagggagt ggcccctatg agtttatatt ttaaccactg cttcaaatct cgatttcact     2940

ttttttattt atccagttat atctacatat ctgtcatcta aataaatggc tttcaaacaa     3000

agcaactggg tcattaaaac cagctcaaag ggggtttaaa aaaaaaaaac cagcccatcc     3060

tttgaggctg atttttcttt tttttaagtt ctattttaaa agctatcaaa cagcgacata     3120

gccatacatc tgactgcctg acatggactc ctgcccactt gggggaaacc ttatacccag     3180

aggaaaatac acacctgggg agtacatttg acaaatttcc cttaggattt cgttatctca     3240

ccttgaccct cagccaagat tggtaaagct gcgtcctggc gattccagga gacccagctg     3300

gaaacctggc ttctccatgt gaggggatgg gaaaggaaag aagagaatga agactactta     3360

gtaattccca tcaggaaatg ctgacctttt acataaaatc aaggagactg ctgaaaatct     3420

ctaagggaca ggattttcca gatcctaatt ggaaatttag caataaggag aggagtccaa     3480

ggggacaaat aaaggcagag agaagagaca gaactaaaaa tacgaggaaa ggagagtgag     3540

gattttcatt aaaagtctca gcagtgggtt tcttgggtta tttaaaacat cacctaaata     3600

ggccttttct tcctaattgg ccatcaaatt aaagcctatc ctttctcaag caggagctgg     3660

tattgtaggg agtggccggg tattctgggc tgggctcttc tggagtaggg ggtcagcaaa     3720

cattgtctgc aaagggccag atactgaatc cagtactttc agtttggcga gccgtgaggt     3780

ctctgtcgaa actactcaac tctgccgtcc tagcacaaaa gcagccatag acaacacaca     3840

aacgagaggg cttggctccc ttccaggaag atttatttaa caggctccca gctgaatttc     3900

actcacagga cacagtttac tgatctctgt tctagtgagt gggtcaaaaa gcatatgcat     3960

ccttatccgt caactcatca gctcttcctc aaggcaacct gaggccagac accaagaaac     4020

caagcgtatc tgctctaaaa tgacttgttc ctggggaatg ccttcaacca aaacacagct     4080

agtatttcta tgccccaaat ccaatcccag tctttcatga tccatgccgg cggttgggtg     4140

gggaggggaa tcattggttg ggggaaggga ggaaacccca cctccagccc ccgccaccgg     4200

gctccctggg cacccagcaa gatctggggc tgcagagaac agaagagctg gtgcacttaa     4260

tccagctctg cccttggggg gaggaggacc tgtgtgtcag gctctgccat gggaacgagt     4320

gtaaaccgtg gctgtctcct gcagtgagcc accgcggcag gcacgttgac tgttttactg     4380

acatcactca aaagctaaag caataacatt ctcctgcgtt gctgagtcag ctgttcattt     4440

gtccgccagc tcctggactg gatgtgtgaa aggcatcaca tttccatttt cctccgtgta     4500

aatgttttat gtgttcgcct actgatccca ttcgttgctt ctattgtaaa tatttgtcat     4560

ttgtatttat tatctctgtg ttttccccct aaggcataaa atggtttact gtgttcattt     4620

gaacccattt actgatctct gttgtatatt tttcatgcca ctgctttgtt ttctcctcag     4680

aagtcgggta gatagcattt ctatcccatc cctcacgtta ttggaagcat gcaacagtat     4740

ttattgctca gggtcttctg cttaaaactg aggaaggtcc acattcctgc aagcattgat     4800

tgagacattt gcacaatcta aaatgtaagc aaagtagtca ttaaaaatac accctctact     4860

tgggctttat actgcataca aatttactca tgagccttcc tttgaggaag gatgtggatc     4920

tccaaataaa gatttagtgt ttattttgag ctctgcatct taacaagatg atctgaacac     4980

ctctcctttg tatcaataaa tagccctgtt attctgaagt gagaggacca agtatagtaa     5040

aatgctgaca tctaaaacta aataaataga aaacaccagg ccagaactat agtcatactc     5100

acacaaaggg agaaatttaa actcgaacca agcaaaaggc ttcacggaaa tagcatggaa     5160

aaacaatgct tccagtggcc acttcctaag gaggaacaac cccgtctgat ctcagaattg     5220

gcaccacgtg agcttgctaa gtgataatat ctgtttctac tacggattta ggcaacagga     5280

cctgtacatt gtcacattgc attatttttc ttcaagcgtt aataaaagtt ttaaataaat     5340

ggcaaaaaaa aaaaaaaaaa a                                               5361


<210> 2
<211> 909
<212> DNA
<213> Homo sapiens

<400> 2
atgtgtgccg agcggctggg ccagttcatg accctggctt tggtgttggc cacctttgac       60

ccggcgcggg ggaccgacgc caccaaccca cccgagggtc cccaagacag gagctcccag      120

cagaaaggcc gcctgtccct gcagaataca gcggagatcc agcactgttt ggtcaacgct      180

ggcgatgtgg ggtgtggcgt gtttgaatgt ttcgagaaca actcttgtga gattcggggc      240

ttacatggga tttgcatgac ttttctgcac aacgctggaa aatttgatgc ccagggcaag      300

tcattcatca aagacgcctt gaaatgtaag gcccacgctc tgcggcacag gttcggctgc      360

ataagccgga agtgcccggc catcagggaa atggtgtccc agttgcagcg ggaatgctac      420

ctcaagcacg acctgtgcgc ggctgcccag gagaacaccc gggtgatagt ggagatgatc      480

catttcaagg acttgctgct gcacgaaccc tacgtggacc tcgtgaactt gctgctgacc      540

tgtggggagg aggtgaagga ggccatcacc cacagcgtgc aggttcagtg tgagcagaac      600

tggggaagcc tgtgctccat cttgagcttc tgcacctcgg ccatccagaa gcctcccacg      660

gcgccccccg agcgccagcc ccaggtggac agaaccaagc tctccagggc ccaccacggg      720

gaagcaggac atcacctccc agagcccagc agtagggaga ctggccgagg tgccaagggt      780

gagcgaggta gcaagagcca cccaaacgcc catgcccgag gcagagtcgg gggccttggg      840

gctcagggac cttccggaag cagcgagtgg gaagacgaac agtctgagta ttctgatatc      900

cggaggtga                                                              909


<210> 3
<211> 302
<212> PRT
<213> Homo sapiens

<400> 3
Met Cys Ala Glu Arg Leu Gly Gln Phe Met Thr Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Thr Phe Asp Pro Ala Arg Gly Thr Asp Ala Thr Asn Pro Pro Glu 
            20                  25                  30          


Gly Pro Gln Asp Arg Ser Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Lys Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Arg Phe Gly Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Arg Glu Met Val Ser Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ala Ala Ala Gln Glu Asn Thr Arg Val Ile Val Glu Met Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Glu Val Lys Glu Ala Ile Thr His Ser 
            180                 185                 190         


Val Gln Val Gln Cys Glu Gln Asn Trp Gly Ser Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Ser Ala Ile Gln Lys Pro Pro Thr Ala Pro Pro Glu 
    210                 215                 220                 


Arg Gln Pro Gln Val Asp Arg Thr Lys Leu Ser Arg Ala His His Gly 
225                 230                 235                 240 


Glu Ala Gly His His Leu Pro Glu Pro Ser Ser Arg Glu Thr Gly Arg 
                245                 250                 255     


Gly Ala Lys Gly Glu Arg Gly Ser Lys Ser His Pro Asn Ala His Ala 
            260                 265                 270         


Arg Gly Arg Val Gly Gly Leu Gly Ala Gln Gly Pro Ser Gly Ser Ser 
        275                 280                 285             


Glu Trp Glu Asp Glu Gln Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295                 300         


<210> 4
<211> 302
<212> PRT
<213> Canis familiaris

<400> 4
Met Cys Ala Glu Arg Leu Gly Gln Phe Val Thr Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Thr Phe Asp Leu Ala Arg Gly Thr Asp Ala Thr Asn Pro Pro Glu 
            20                  25                  30          


Gly Pro Gln Asp Arg Gly Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Lys Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Arg Phe Gly Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Lys Glu Met Val Phe Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ser Ala Ala Gln Glu Asn Thr Arg Val Met Val Glu Met Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Glu Val Lys Glu Ala Ile Thr His Ser 
            180                 185                 190         


Val Gln Ala Gln Cys Glu Gln Asn Trp Gly Ser Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Ser Ala Ile Gln Arg Pro Pro Thr Val Pro Pro Glu 
    210                 215                 220                 


Arg Gln Leu Gln Val Asp Arg Ala Lys Leu Ser Lys Thr His His Gly 
225                 230                 235                 240 


Glu Ala Gly His His Val Ser Glu Pro Ser Ser Trp Glu Thr Gly Arg 
                245                 250                 255     


Gly Thr Lys Gly Glu Gly Gly Ser Lys Ser His Leu Asn Ala His Ala 
            260                 265                 270         


Arg Gly Arg Ala Val Gly Gln Gly Gly Gln Gly Thr Ser Gly Ser Ser 
        275                 280                 285             


Glu Trp Glu Glu Glu Pro Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295                 300         


<210> 5
<211> 302
<212> PRT
<213> Felis catus

<400> 5
Met Cys Ala Glu Arg Leu Gly Gln Phe Val Thr Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Thr Phe Asp Pro Ala Arg Gly Thr Asp Ala Thr Asn Pro Pro Glu 
            20                  25                  30          


Gly Pro Gln Asp Arg Gly Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Glu Ala Leu Lys Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Arg Phe Gly Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Lys Glu Met Val Phe Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ser Ala Ala Gln Glu Asn Thr Arg Val Met Val Glu Met Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Glu Val Lys Glu Ala Ile Thr His Ser 
            180                 185                 190         


Val Gln Ala Gln Cys Glu Gln Asn Trp Gly Ser Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Ser Ala Ile Gln Arg Pro Pro Thr Val Pro Pro Glu 
    210                 215                 220                 


Arg Gln Leu Gln Val Asp Arg Ala Lys Leu Ser Arg Ala His His Gly 
225                 230                 235                 240 


Asp Thr Gly His His Leu Ser Glu Ala Ser Ser Arg Glu Thr Gly Arg 
                245                 250                 255     


Gly Val Lys Gly Glu Arg Gly Ser Lys Ser His Pro Asn Ala His Ala 
            260                 265                 270         


Arg Gly Arg Ala Ala Gly His Gly Gly Gln Gly Thr Ser Gly Ser Ser 
        275                 280                 285             


Glu Trp Glu Glu Glu Gln Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295                 300         


<210> 6
<211> 302
<212> PRT
<213> Equus caballus

<400> 6
Met Cys Thr Glu Arg Leu Gly Gln Phe Met Thr Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Thr Phe Asp Pro Ala Arg Gly Thr Asp Ala Thr His Pro Pro Glu 
            20                  25                  30          


Gly Pro Gln Asp Arg Gly Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Lys Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Arg Phe Gly Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Lys Glu Met Val Phe Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ser Ala Ala Gln Glu Asn Thr Arg Val Met Val Glu Ile Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Glu Val Lys Glu Ala Ile Thr His Ser 
            180                 185                 190         


Val Gln Ala Gln Cys Glu Gln Ser Trp Gly Ser Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Ser Ala Ile Gln Arg Pro Pro Thr Val Pro Pro Glu 
    210                 215                 220                 


Arg Arg Leu Gln Gly Asp Arg Ala Arg Leu Ser Arg Ala His His Glu 
225                 230                 235                 240 


Glu Ala Gly His His Leu Ser Glu Pro Ser Ser Gln Glu Thr Gly Arg 
                245                 250                 255     


Gly Ala Lys Gly Glu Arg Gly Ser Lys Ser His Pro Asn Thr His Ala 
            260                 265                 270         


Arg Gly Arg Ala Gly Gly His Gly Ala Gln Gly Thr Ser Gly Ser Ser 
        275                 280                 285             


Glu Trp Glu Asp Glu Gln Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295                 300         


<210> 7
<211> 302
<212> PRT
<213> Bos taurus

<400> 7
Met Cys Ala Glu Arg Leu Gly Gln Phe Val Thr Leu Ala Leu Val Leu 
1               5                   10                  15      


Val Thr Phe Asp Pro Ala Arg Gly Thr Asp Ala Thr Asn Thr Pro Glu 
            20                  25                  30          


Gly Pro Gln Asp Arg Gly Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Lys Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Arg Phe Ser Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Lys Glu Met Val Phe Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ser Ala Ala Gln Glu Asn Ile Arg Val Met Val Glu Met Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Glu Val Lys Glu Ala Ile Thr His Ser 
            180                 185                 190         


Val Gln Ala Gln Cys Glu Gln Ser Trp Gly Ser Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Ser Ala Ile Gln Arg Pro Pro Thr Ala Pro Pro Glu 
    210                 215                 220                 


His Gln Leu Gln Gly Asp Arg Ala Lys Leu Ser Arg Gly His Pro Ala 
225                 230                 235                 240 


Glu Met Gly His His Leu Ala Glu Pro Ser Ser Arg Glu Thr Gly Arg 
                245                 250                 255     


Gly Ala Lys Gly Glu Arg Gly Ser Lys Ser His Pro Asn Ala His Ala 
            260                 265                 270         


Arg Gly Arg Ala Ala Gly Pro Gly Ala Gln Gly Thr Ser Gly Ser Ser 
        275                 280                 285             


Glu Trp Glu Asp Glu Gln Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295                 300         


<210> 8
<211> 301
<212> PRT
<213> Sus scrofa

<400> 8
Met Cys Ala Glu Arg Leu Gly Gln Phe Val Thr Leu Ala Leu Leu Leu 
1               5                   10                  15      


Ala Thr Phe Asp Pro Ala Arg Gly Thr Glu Ala Thr Asn Pro Pro Glu 
            20                  25                  30          


Ser Pro Gln Asp Arg Gly Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Lys Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Arg Phe Gly Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Lys Glu Met Val Phe Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ser Ala Ala Gln Glu Asn Thr Arg Val Met Val Glu Met Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Glu Val Lys Glu Ala Ile Thr His Ser 
            180                 185                 190         


Val Gln Ala Gln Cys Glu Gln Asn Trp Gly Ser Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Ser Ala Ile Gln Arg Pro Pro Thr Ala Pro Pro Glu 
    210                 215                 220                 


His Pro Pro Gln Gly Asp Arg Ala Lys Pro Ser Arg Ala His Gly Glu 
225                 230                 235                 240 


Ala Gly His Pro Leu Ser Glu Pro Ser Ser Arg Glu Thr Gly Arg Gly 
                245                 250                 255     


Ala Lys Gly Glu Arg Ala Ser Lys Ser His Pro Ile Ala His Ala Arg 
            260                 265                 270         


Gly Arg Ala Ala Gly His Gly Ala Gln Gly Thr Ser Gly Ser Ser Glu 
        275                 280                 285             


Trp Glu Asp Glu Gln Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295                 300     


<210> 9
<211> 302
<212> PRT
<213> Oryctolagus cuniculus

<400> 9
Met Cys Ala Glu Arg Leu Gly Arg Phe Val Thr Leu Thr Leu Val Phe 
1               5                   10                  15      


Ala Thr Phe Asp Leu Ala Arg Gly Thr Asp Ala Thr His Pro Pro Glu 
            20                  25                  30          


Gly Leu Pro Asp Arg Gly Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Lys Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Arg Phe Gly Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Lys Glu Met Val Phe Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ser Ala Ala Gln Asp Asn Ile Arg Val Ile Val Glu Met Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Glu Val Lys Glu Ala Val Thr His Ser 
            180                 185                 190         


Val Gln Ala Gln Cys Glu Gln Asn Trp Gly Gly Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Pro Thr Ile Gln Arg Pro Pro Thr Ala Leu Pro Glu 
    210                 215                 220                 


Arg Gln Leu Gln Val Asp Arg Thr Lys Leu Pro Arg Ala His His Gly 
225                 230                 235                 240 


Glu Ala Gly Pro His His Ala Glu Pro Ser Ser Lys Glu Thr Ser Arg 
                245                 250                 255     


Gly Ala Lys Gly Glu Arg Gly Ser Arg Ser His Pro Asn Ala His Ala 
            260                 265                 270         


Arg Gly Arg Ala Gly Ser Pro Gly Ala Gln Gly Pro Ser Gly Ser Ser 
        275                 280                 285             


Glu Trp Glu Asp Glu Gln Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295                 300         


<210> 10
<211> 302
<212> PRT
<213> Ovis aries

<400> 10
Met Cys Ala Glu Arg Leu Gly Gln Phe Val Thr Leu Ala Leu Val Leu 
1               5                   10                  15      


Val Thr Phe Asp Pro Ala Arg Gly Thr Asp Ala Thr Asn Thr Pro Glu 
            20                  25                  30          


Gly Pro Gln Asp Arg Gly Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Lys Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Arg Phe Ser Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Lys Glu Met Val Phe Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ser Ala Ala Gln Glu Asn Ile Arg Val Met Val Glu Met Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Asp Pro Thr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Glu Val Lys Glu Ala Ile Thr His Ser 
            180                 185                 190         


Val Gln Ala Gln Cys Glu Gln Ser Trp Gly Ser Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Ser Ala Ile Gln Arg Pro Pro Thr Ala Pro Pro Glu 
    210                 215                 220                 


Arg Gln Leu Gln Gly Asp Arg Ala Lys Leu Ser Arg Gly His Pro Ala 
225                 230                 235                 240 


Glu Met Gly His His Leu Ala Glu Pro Ser Ser Arg Glu Thr Gly Arg 
                245                 250                 255     


Gly Ala Lys Gly Glu Arg Gly Ser Lys Ser His Pro Asn Ala His Ala 
            260                 265                 270         


Arg Gly Arg Thr Ala Gly Pro Gly Ala Gln Gly Thr Ser Gly Ser Ser 
        275                 280                 285             


Glu Trp Glu Asp Glu Gln Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295                 300         


<210> 11
<211> 302
<212> PRT
<213> Macaca nemestrina

<400> 11
Met Cys Ala Glu Arg Leu Gly His Phe Met Thr Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Thr Ile Asp Pro Ala Arg Gly Thr Asp Ala Thr Asn Pro Pro Glu 
            20                  25                  30          


Gly Pro Gln Asp Arg Ser Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Lys Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Arg Phe Gly Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Arg Glu Met Val Phe Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ala Ala Ala Gln Glu Asn Thr Arg Val Ile Val Glu Met Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Glu Val Lys Glu Ala Ile Thr His Ser 
            180                 185                 190         


Val Gln Val Gln Cys Glu Gln Asn Trp Gly Ser Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Ser Ala Ile Gln Arg Pro Pro Thr Ala Pro Pro Glu 
    210                 215                 220                 


Arg Gln Pro Gln Val Asp Arg Ala Lys Leu Ser Arg Ala His His Gly 
225                 230                 235                 240 


Glu Ala Gly His His Leu Pro Glu Pro Ser Ser Arg Glu Thr Gly Arg 
                245                 250                 255     


Gly Ala Lys Gly Glu Arg Gly Ser Lys Ser His Pro Asn Ala His Ala 
            260                 265                 270         


Arg Gly Arg Val Gly Gly Leu Gly Ala Gln Gly Pro Ser Gly Ser Ser 
        275                 280                 285             


Glu Trp Glu Asp Glu Gln Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295                 300         


<210> 12
<211> 302
<212> PRT
<213> Pan troglodytes

<400> 12
Met Cys Ala Glu Arg Leu Gly Gln Phe Met Thr Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Thr Phe Asp Pro Ala Arg Gly Thr Asp Ala Thr Asn Pro Pro Glu 
            20                  25                  30          


Gly Pro Gln Asp Arg Ser Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Lys Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Arg Phe Gly Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Arg Glu Met Val Ser Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ala Ala Ala Gln Glu Asn Thr Arg Val Ile Val Glu Met Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Glu Val Lys Glu Ala Ile Thr His Ser 
            180                 185                 190         


Val Gln Val Gln Cys Glu Gln Asn Trp Gly Ser Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Ser Ala Ile Gln Arg Pro Pro Thr Ala Pro Pro Glu 
    210                 215                 220                 


Arg Gln Pro Gln Val Asp Arg Thr Lys Leu Ser Arg Ala His His Gly 
225                 230                 235                 240 


Glu Ala Gly His His Leu Pro Glu Pro Ser Ser Arg Glu Thr Gly Arg 
                245                 250                 255     


Gly Ala Lys Gly Glu Arg Gly Ser Lys Ser His Pro Asn Ala His Ala 
            260                 265                 270         


Arg Gly Arg Val Gly Gly Leu Gly Ala Gln Gly Pro Ser Gly Ser Ser 
        275                 280                 285             


Glu Trp Glu Asp Glu Gln Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295                 300         


<210> 13
<211> 296
<212> PRT
<213> Mus musculus

<400> 13
Met Cys Ala Glu Arg Leu Gly Gln Phe Val Thr Leu Ala Leu Val Phe 
1               5                   10                  15      


Ala Thr Leu Asp Pro Ala Gln Gly Thr Asp Ser Thr Asn Pro Pro Glu 
            20                  25                  30          


Gly Pro Gln Asp Arg Ser Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Gln Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Arg Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Lys Phe Gly Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Arg Glu Met Val Phe Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ser Ala Ala Gln Glu Asn Val Gly Val Ile Val Glu Met Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Asp Val Lys Glu Ala Val Thr Arg Ser 
            180                 185                 190         


Val Gln Ala Gln Cys Glu Gln Ser Trp Gly Gly Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Ser Asn Ile Gln Arg Pro Pro Thr Ala Ala Pro Glu 
    210                 215                 220                 


His Gln Pro Leu Ala Asp Arg Ala Gln Leu Ser Arg Pro His His Arg 
225                 230                 235                 240 


Asp Thr Asp His His Leu Thr Ala Asn Arg Gly Ala Lys Gly Glu Arg 
                245                 250                 255     


Gly Ser Lys Ser His Pro Asn Ala His Ala Arg Gly Arg Thr Gly Gly 
            260                 265                 270         


Gln Ser Ala Gln Gly Pro Ser Gly Ser Ser Glu Trp Glu Asp Glu Gln 
        275                 280                 285             


Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295     


<210> 14
<211> 296
<212> PRT
<213> Rattus norvegicus

<400> 14
Met Cys Ala Glu Arg Leu Gly Gln Phe Val Thr Leu Ala Leu Val Phe 
1               5                   10                  15      


Ala Thr Leu Asp Pro Ala Arg Gly Thr Asp Ser Thr Asn Pro Pro Glu 
            20                  25                  30          


Gly Pro Gln Asp Arg Gly Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Gln Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Arg Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Lys Phe Gly Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Arg Glu Met Val Tyr Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ser Ala Ala Gln Glu Asn Val Val Val Ile Val Glu Met Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Asp Val Arg Glu Ala Val Thr Arg Ser 
            180                 185                 190         


Val Gln Ala Gln Cys Glu Gln Ser Trp Gly Gly Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Ser Asn Ile Gln Arg Pro Pro Thr Ala Ala Pro Glu 
    210                 215                 220                 


His Gln Pro Leu Ala Asp Arg Ala Gln Leu Ser Arg Pro Tyr His Arg 
225                 230                 235                 240 


Asp Thr Asp His His Leu Thr Ala Asn Arg Gly Ala Lys Gly Glu Arg 
                245                 250                 255     


Gly Ser Lys Ser His Leu His Ala His Ala Arg Gly Gly Ala Gly Gly 
            260                 265                 270         


Gln Ser Ala Gln Gly Pro Ser Gly Ser Ser Glu Trp Glu Asp Glu Gln 
        275                 280                 285             


Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295     


<210> 15
<211> 302
<212> PRT
<213> Cavia porcellus

<400> 15
Met Cys Ala Glu Arg Leu Gly Gln Phe Val Thr Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Thr Phe Asp Pro Ala Arg Gly Thr Asp Ala Thr Asn Pro Pro Glu 
            20                  25                  30          


Gly Pro Gln Asp Arg Gly Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln 
        35                  40                  45              


Asn Thr Ala Asp Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly 
    50                  55                  60                  


Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly 
65                  70                  75                  80  


Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp 
                85                  90                  95      


Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Lys Cys Lys Ala His 
            100                 105                 110         


Ala Leu Arg His Arg Phe Gly Cys Ile Ser Arg Lys Cys Pro Ala Ile 
        115                 120                 125             


Lys Glu Met Val Phe Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp 
    130                 135                 140                 


Leu Cys Ala Ala Ala Gln Glu Asn Thr Arg Val Leu Val Glu Met Ile 
145                 150                 155                 160 


His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn 
                165                 170                 175     


Leu Leu Leu Thr Cys Gly Glu Glu Val Lys Glu Ala Ile Ser His Ser 
            180                 185                 190         


Val Gln Ala Gln Cys Glu Gln Asn Trp Gly Gly Leu Cys Ser Ile Leu 
        195                 200                 205             


Ser Phe Cys Thr Ser Ala Met His Arg Pro Pro Thr Val Ser Pro Glu 
    210                 215                 220                 


His Gln Leu Gln Met Asp Arg Ala Arg Leu Ser Arg Thr His Gln Gly 
225                 230                 235                 240 


Glu Ala Ser His Tyr Phe Ser Glu Pro Ser Ser Arg Glu Ser Ile Arg 
                245                 250                 255     


Asp Ala Lys Gly Glu Arg Gly Ser Lys Gly His Ser Asn Ala His Ala 
            260                 265                 270         


Arg Gly Arg Ala Gly Gly His Gly Ala Gln Gly Pro Ser Gly Ser Ser 
        275                 280                 285             


Glu Trp Glu Asp Glu Gln Ser Glu Tyr Ser Asp Ile Arg Arg 
    290                 295                 300         


<210> 16
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Glycosylated Ser

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Glycosylated Ser

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Glycosylated Ser

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Glycosylated Ser

<400> 16
Phe Gln Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro 
1               5                   10                  15      


Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25                  30  


