                         SEQUENCE LISTING

<110>  CORNELL UNIVERSITY
 
<120>  CANCER IMMUNOTHERAPIES TO PROMOTE HYPERACUTE REJECTION

<130>  147402.008272

<140>  PCT/US2021/061180
<141>  2021-11-30

<150>  63/119,359
<151>  2020-11-30

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  1

Gly Gly Gly Gly Ser 
1               5   


<210>  2
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Ser at position 16 and Gly at positions 17-20 are either all 
       present or all absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  Ser at position 21 and Gly at positions 22-25 are either all 
       present or all absent

<220>
<221>  MISC_FEATURE
<222>  (26)..(30)
<223>  Ser at position 26 and Gly at positions 27-30 are either all 
       present or all absent

<400>  2

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30      


<210>  3
<211>  115
<212>  PRT
<213>  Homo sapiens

<300>
<308>  GenBank Accession No. CCA78124.1
<309>  2016-07-25
<313>  (1)..(115)

<400>  3

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  4
<211>  108
<212>  PRT
<213>  Homo sapiens

<300>
<308>  CCA78125.1
<309>  2016-07-25
<313>  (1)..(108)

<400>  4

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Thr Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  5
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  6
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  7
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Glu Val Leu Arg Thr Leu Ala Gly Lys Pro Lys Cys His Ala 
1               5                   10                  15      


Leu Arg Pro Met Ile Leu Phe Leu Ile Met Leu Val Leu Val Leu Phe 
            20                  25                  30          


Gly Tyr Gly Val Leu Ser Pro Arg Ser Leu Met Pro Gly Ser Leu Glu 
        35                  40                  45              


Arg Gly Phe Cys Met Ala Val Arg Glu Pro Asp His Leu Gln Arg Val 
    50                  55                  60                  


Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys 
65                  70                  75                  80  


Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp 
                85                  90                  95      


Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln 
            100                 105                 110         


Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala 
        115                 120                 125             


Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly 
    130                 135                 140                 


His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro 
145                 150                 155                 160 


Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Gly 
                165                 170                 175     


Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile 
            180                 185                 190         


Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val 
        195                 200                 205             


Cys Val Asp Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile 
    210                 215                 220                 


Leu Thr Pro Leu Phe Gly Thr Leu His Pro Ser Phe Tyr Gly Ser Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile 
                245                 250                 255     


Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly 
            260                 265                 270         


Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met 
        275                 280                 285             


Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser 
    290                 295                 300                 


His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser 
305                 310                 315                 320 


Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg 
            340                 345                 350         


Asn Pro 
        


<210>  8
<211>  229
<212>  PRT
<213>  Homo sapiens

<300>
<308>  ABL75287.1
<309>  2016-07-14
<313>  (1)..(229)

<400>  8

Tyr Val Ala Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe 
1               5                   10                  15      


Met Val Gly His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala 
            20                  25                  30          


Ala Val Pro Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu 
        35                  40                  45              


Glu Val Gly Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met 
    50                  55                  60                  


Glu Met Ile Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp 
65                  70                  75                  80  


Tyr Leu Val Cys Val Asp Val Asp Met Glu Phe Arg Asp His Val Gly 
                85                  90                  95      


Val Glu Ile Leu Thr Pro Leu Phe Gly Thr Leu His Pro Ser Phe Tyr 
            100                 105                 110         


Gly Ser Ser Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln 
        115                 120                 125             


Ala Tyr Ile Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Met Gly Gly Phe 
    130                 135                 140                 


Phe Gly Gly Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His 
145                 150                 155                 160 


Gln Ala Met Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His 
                165                 170                 175     


Asp Glu Ser His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys 
            180                 185                 190         


Val Leu Ser Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro 
        195                 200                 205             


Ala Val Leu Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln 
    210                 215                 220                 


Ala Val Arg Asn Pro 
225                 


<210>  9
<211>  354
<212>  PRT
<213>  Homo sapiens

<300>
<308>  AFB74122.1
<309>  2012-02-27
<313>  (1)..(354)

<400>  9

Met Ala Glu Val Leu Arg Thr Leu Ala Gly Lys Pro Lys Cys His Ala 
1               5                   10                  15      


Leu Arg Pro Met Ile Leu Phe Leu Ile Met Leu Val Leu Val Leu Phe 
            20                  25                  30          


Gly Tyr Gly Val Leu Ser Pro Arg Ser Leu Met Pro Gly Ser Leu Glu 
        35                  40                  45              


Arg Gly Phe Cys Met Ala Val Arg Glu Pro Asp His Leu Gln Arg Val 
    50                  55                  60                  


Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys 
65                  70                  75                  80  


Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp 
                85                  90                  95      


Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln 
            100                 105                 110         


Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala 
        115                 120                 125             


Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Leu Met Val Gly 
    130                 135                 140                 


His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro 
145                 150                 155                 160 


Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Arg 
                165                 170                 175     


Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile 
            180                 185                 190         


Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val 
        195                 200                 205             


Cys Val Asp Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile 
    210                 215                 220                 


Leu Thr Pro Leu Phe Gly Thr Leu His Pro Gly Phe Tyr Gly Ser Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile 
                245                 250                 255     


Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Leu Gly Gly Phe Phe Gly Gly 
            260                 265                 270         


Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met 
        275                 280                 285             


Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser 
    290                 295                 300                 


His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser 
305                 310                 315                 320 


Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg 
            340                 345                 350         


Asn Pro 
        


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 HCDR1

<400>  10

Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 HCDR1

<400>  11

Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
1               5                   10  


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  obexelimab HCDR1

<400>  12

Ser Tyr Val Met His 
1               5   


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 HCDR2

<400>  13

Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
1               5                   10                  15      


Asp 
    


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 HCDR2

<400>  14

Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  obexelimab HCDR2

<400>  15

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 HCDR3

<400>  16

Gly Trp Asn Phe Asp Tyr 
1               5       


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 HCDR3

<400>  17

Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  obexelimab HCDR3

<400>  18

Gly Thr Tyr Tyr Tyr Gly Thr Arg Val Phe Asp Tyr 
1               5                   10          


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 LCDR1

<400>  19

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Asp 
1               5                   10      


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 LCDR1

<400>  20

Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp 
1               5                   10          


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  obexelimab LCDR1

<400>  21

Arg Ser Ser Lys Ser Leu Gln Asn Val Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 LCDR2

<400>  22

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 LCDR2

<400>  23

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  obexelimab LCDR2

<400>  24

Arg Met Ser Asn Leu Asn Ser 
1               5           


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 LCDR3

<400>  25

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 LCDR3

<400>  26

Gln Gln His Tyr Thr Thr Pro Pro 
1               5               


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  obexelimab LCDR3

<400>  27

Met Gln His Leu Glu Tyr Pro Ile Thr 
1               5                   


<210>  28
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 variable heavy chain

<400>  28

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  29
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 variable light chain

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Pro Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  30
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 variable heavy chain

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  31
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 variable light chain

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  32
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  obexelimab variable heavy chain

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ser Ser Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Thr Arg Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  33
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  obexelimab variable light chain

<400>  33

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Lys Ser Leu Gln Asn Val 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Asn Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  34
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide-huJ591 H chain-GTB

<400>  34

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
465                 470                 475                 480 


Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met Val Tyr Pro Gln 
                485                 490                 495     


Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu Val Val Thr Pro 
            500                 505                 510         


Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn Ile Asp Ile Leu 
        515                 520                 525             


Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu Thr Val Phe 
    530                 535                 540                 


Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu Glu Thr Ala 
545                 550                 555                 560 


Glu Lys His Phe Met Val Gly His Arg Val His Tyr Tyr Val Phe Thr 
                565                 570                 575     


Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly Thr Gly Arg Gln 
            580                 585                 590         


Leu Ser Val Leu Glu Val Gly Ala Tyr Lys Arg Trp Gln Asp Val Ser 
        595                 600                 605             


Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu Arg Arg Phe Leu 
    610                 615                 620                 


Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp Met Glu Phe Arg 
625                 630                 635                 640 


Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe Gly Thr Leu His 
                645                 650                 655     


Pro Ser Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr Glu Arg Arg 
            660                 665                 670         


Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp Phe Tyr Tyr 
        675                 680                 685             


Met Gly Ala Phe Phe Gly Gly Ser Val Gln Glu Val Gln Arg Leu Thr 
    690                 695                 700                 


Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala Asn Gly Ile Glu 
705                 710                 715                 720 


Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr Leu Leu Arg His 
                725                 730                 735     


Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp Gln Gln Leu 
            740                 745                 750         


Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe Thr Ala Val Pro 
        755                 760                 765             


Lys Asn His Gln Ala Val Arg Asn Pro 
    770                 775         


<210>  35
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide-huJ591 H chain-GTA

<400>  35

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
465                 470                 475                 480 


Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met Val Tyr Pro Gln 
                485                 490                 495     


Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu Val Val Thr Pro 
            500                 505                 510         


Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn Ile Asp Ile Leu 
        515                 520                 525             


Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu Thr Val Phe 
    530                 535                 540                 


Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu Glu Thr Ala 
545                 550                 555                 560 


Glu Lys His Phe Met Val Gly His Arg Val His Tyr Tyr Val Phe Thr 
                565                 570                 575     


Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly Thr Gly Arg Gln 
            580                 585                 590         


Leu Ser Val Leu Glu Val Arg Ala Tyr Lys Arg Trp Gln Asp Val Ser 
        595                 600                 605             


Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu Arg Arg Phe Leu 
    610                 615                 620                 


Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp Met Glu Phe Arg 
625                 630                 635                 640 


Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe Gly Thr Leu His 
                645                 650                 655     


Pro Gly Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr Glu Arg Arg 
            660                 665                 670         


Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp Phe Tyr Tyr 
        675                 680                 685             


Leu Gly Gly Phe Phe Gly Gly Ser Val Gln Glu Val Gln Arg Leu Thr 
    690                 695                 700                 


Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala Asn Gly Ile Glu 
705                 710                 715                 720 


Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr Leu Leu Arg His 
                725                 730                 735     


Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp Gln Gln Leu 
            740                 745                 750         


Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe Thr Ala Val Pro 
        755                 760                 765             


Lys Asn His Gln Ala Val Arg Asn Pro 
    770                 775         


<210>  36
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide- huJ591-LC-his tag

<400>  36

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Leu Thr Cys Lys Ala Ser Gln Asp Val 
        35                  40                  45              


Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Pro Ser Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser 
            100                 105                 110         


Tyr Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys His His His His His His 
225                 230                 235                 


<210>  37
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide-huJ591Fab-GTB-Myc-his tag

<400>  37

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met Val 
                245                 250                 255     


Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu Val 
            260                 265                 270         


Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn Ile 
        275                 280                 285             


Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu 
    290                 295                 300                 


Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu 
305                 310                 315                 320 


Glu Thr Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr Tyr 
                325                 330                 335     


Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly Thr 
            340                 345                 350         


Gly Arg Gln Leu Ser Val Leu Glu Val Gly Ala Tyr Lys Arg Trp Gln 
        355                 360                 365             


Asp Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu Arg 
    370                 375                 380                 


Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp Met 
385                 390                 395                 400 


Glu Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe Gly 
                405                 410                 415     


Thr Leu His Pro Ser Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr 
            420                 425                 430         


Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp 
        435                 440                 445             


Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly Ser Val Gln Glu Val Gln 
    450                 455                 460                 


Arg Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala Asn 
465                 470                 475                 480 


Gly Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr Leu 
                485                 490                 495     


Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp 
            500                 505                 510         


Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe Thr 
        515                 520                 525             


Ala Val Pro Lys Asn His Gln Ala Val Arg Asn Pro Ala Ala Ala Glu 
    530                 535                 540                 


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Val Glu His His 
545                 550                 555                 560 


His His His His 
                


<210>  38
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide-huJ591Fab-GTA-Myc-his tag

<400>  38

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met Val 
                245                 250                 255     


Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu Val 
            260                 265                 270         


Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn Ile 
        275                 280                 285             


Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu 
    290                 295                 300                 


Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu 
305                 310                 315                 320 


Glu Thr Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr Tyr 
                325                 330                 335     


Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly Thr 
            340                 345                 350         


Gly Arg Gln Leu Ser Val Leu Glu Val Arg Ala Tyr Lys Arg Trp Gln 
        355                 360                 365             


Asp Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu Arg 
    370                 375                 380                 


Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp Met 
385                 390                 395                 400 


Glu Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe Gly 
                405                 410                 415     


Thr Leu His Pro Gly Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr 
            420                 425                 430         


Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp 
        435                 440                 445             


Phe Tyr Tyr Leu Gly Gly Phe Phe Gly Gly Ser Val Gln Glu Val Gln 
    450                 455                 460                 


Arg Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala Asn 
465                 470                 475                 480 


Gly Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr Leu 
                485                 490                 495     


Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp 
            500                 505                 510         


Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe Thr 
        515                 520                 525             


Ala Val Pro Lys Asn His Gln Ala Val Arg Asn Pro Ala Ala Ala Glu 
    530                 535                 540                 


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Val Glu His His 
545                 550                 555                 560 


His His His His 
                


<210>  39
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide- huJ591-LC

<400>  39

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Leu Thr Cys Lys Ala Ser Gln Asp Val 
        35                  40                  45              


Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Pro Ser Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser 
            100                 105                 110         


Tyr Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  40
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591-HC67-GTB

<400>  40

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Val 
    210                 215                 220                 


Pro Pro Val Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Val Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Arg Leu Ala Ser Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Asp His 
    450                 455                 460                 


Leu Gln Arg Val Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val 
465                 470                 475                 480 


Leu Thr Pro Cys Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala 
                485                 490                 495     


Pro Ile Val Trp Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln 
            500                 505                 510         


Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys 
        515                 520                 525             


Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His 
    530                 535                 540                 


Phe Met Val Gly His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro 
545                 550                 555                 560 


Ala Ala Val Pro Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val 
                565                 570                 575     


Leu Glu Val Gly Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg 
            580                 585                 590         


Met Glu Met Ile Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val 
        595                 600                 605             


Asp Tyr Leu Val Cys Val Asp Val Asp Met Glu Phe Arg Asp His Val 
    610                 615                 620                 


Gly Val Glu Ile Leu Thr Pro Leu Phe Gly Thr Leu His Pro Ser Phe 
625                 630                 635                 640 


Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser 
                645                 650                 655     


Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Met Gly Ala 
            660                 665                 670         


Phe Phe Gly Gly Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys 
        675                 680                 685             


His Gln Ala Met Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp 
    690                 695                 700                 


His Asp Glu Ser His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr 
705                 710                 715                 720 


Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp 
                725                 730                 735     


Pro Ala Val Leu Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His 
            740                 745                 750         


Gln Ala Val Arg Asn Pro 
        755             


<210>  41
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591-HC67-GTA

<400>  41

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Val 
    210                 215                 220                 


Pro Pro Val Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Val Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Arg Leu Ala Ser Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Asp His 
    450                 455                 460                 


Leu Gln Arg Val Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val 
465                 470                 475                 480 


Leu Thr Pro Cys Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala 
                485                 490                 495     


Pro Ile Val Trp Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln 
            500                 505                 510         


Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys 
        515                 520                 525             


Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His 
    530                 535                 540                 


Phe Met Val Gly His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro 
545                 550                 555                 560 


Ala Ala Val Pro Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val 
                565                 570                 575     


Leu Glu Val Arg Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg 
            580                 585                 590         


Met Glu Met Ile Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val 
        595                 600                 605             


Asp Tyr Leu Val Cys Val Asp Val Asp Met Glu Phe Arg Asp His Val 
    610                 615                 620                 


Gly Val Glu Ile Leu Thr Pro Leu Phe Gly Thr Leu His Pro Gly Phe 
625                 630                 635                 640 


Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser 
                645                 650                 655     


Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Leu Gly Gly 
            660                 665                 670         


Phe Phe Gly Gly Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys 
        675                 680                 685             


His Gln Ala Met Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp 
    690                 695                 700                 


His Asp Glu Ser His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr 
705                 710                 715                 720 


Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp 
                725                 730                 735     


Pro Ala Val Leu Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His 
            740                 745                 750         


Gln Ala Val Arg Asn Pro 
        755             


<210>  42
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591-LC-his tag

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Pro Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His His His His His His 
    210                 215                 220 


<210>  43
<211>  831
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591 HC67 -GTB-54aa

<400>  43

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Val Pro Pro Val Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Lys 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Val Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Arg Leu Ala Ser Tyr Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
465                 470                 475                 480 


Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met Val Tyr Pro Gln 
                485                 490                 495     


Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu Val Val Thr Pro 
            500                 505                 510         


Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn Ile Asp Ile Leu 
        515                 520                 525             


Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu Thr Val Phe 
    530                 535                 540                 


Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu Glu Thr Ala 
545                 550                 555                 560 


Glu Lys His Phe Met Val Gly His Arg Val His Tyr Tyr Val Phe Thr 
                565                 570                 575     


Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly Thr Gly Arg Gln 
            580                 585                 590         


Leu Ser Val Leu Glu Val Gly Ala Tyr Lys Arg Trp Gln Asp Val Ser 
        595                 600                 605             


Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu Arg Arg Phe Leu 
    610                 615                 620                 


Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp Met Glu Phe Arg 
625                 630                 635                 640 


Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe Gly Thr Leu His 
                645                 650                 655     


Pro Ser Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr Glu Arg Arg 
            660                 665                 670         


Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp Phe Tyr Tyr 
        675                 680                 685             


Met Gly Ala Phe Phe Gly Gly Ser Val Gln Glu Val Gln Arg Leu Thr 
    690                 695                 700                 


Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala Asn Gly Ile Glu 
705                 710                 715                 720 


Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr Leu Leu Arg His 
                725                 730                 735     


Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp Gln Gln Leu 
            740                 745                 750         


Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe Thr Ala Val Pro 
        755                 760                 765             


Lys Asn His Gln Ala Val Arg Asn Pro Glu Phe Glu Gln Lys Leu Ile 
    770                 775                 780                 


Ser Glu Glu Asp Leu Asn Ser Ala Asp Ile His His Thr Gly Ala Arg 
785                 790                 795                 800 


Ser Ser Ala His Leu Glu Leu Thr Ala Asp Tyr Lys Asp His Asp Gly 
                805                 810                 815     


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
            820                 825                 830     


<210>  44
<211>  831
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591-HC67-GTA-54aa

<400>  44

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Val Pro Pro Val Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Lys 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Val Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Arg Leu Ala Ser Tyr Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
465                 470                 475                 480 


Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met Val Tyr Pro Gln 
                485                 490                 495     


Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu Val Val Thr Pro 
            500                 505                 510         


Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn Ile Asp Ile Leu 
        515                 520                 525             


Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu Thr Val Phe 
    530                 535                 540                 


Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu Glu Thr Ala 
545                 550                 555                 560 


Glu Lys His Phe Met Val Gly His Arg Val His Tyr Tyr Val Phe Thr 
                565                 570                 575     


Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly Thr Gly Arg Gln 
            580                 585                 590         


Leu Ser Val Leu Glu Val Arg Ala Tyr Lys Arg Trp Gln Asp Val Ser 
        595                 600                 605             


Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu Arg Arg Phe Leu 
    610                 615                 620                 


Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp Met Glu Phe Arg 
625                 630                 635                 640 


Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe Gly Thr Leu His 
                645                 650                 655     


Pro Gly Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr Glu Arg Arg 
            660                 665                 670         


Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp Phe Tyr Tyr 
        675                 680                 685             


Leu Gly Gly Phe Phe Gly Gly Ser Val Gln Glu Val Gln Arg Leu Thr 
    690                 695                 700                 


Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala Asn Gly Ile Glu 
705                 710                 715                 720 


Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr Leu Leu Arg His 
                725                 730                 735     


Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp Gln Gln Leu 
            740                 745                 750         


Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe Thr Ala Val Pro 
        755                 760                 765             


Lys Asn His Gln Ala Val Arg Asn Pro Glu Phe Glu Gln Lys Leu Ile 
    770                 775                 780                 


Ser Glu Glu Asp Leu Asn Ser Ala Asp Ile His His Thr Gly Ala Arg 
785                 790                 795                 800 


Ser Ser Ala His Leu Glu Leu Thr Ala Asp Tyr Lys Asp His Asp Gly 
                805                 810                 815     


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
            820                 825                 830     


<210>  45
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591-LC-his tag

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Pro Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His His His His His His 
    210                 215                 220 


<210>  46
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591scFv-Fc67-GTB-his tag

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Pro Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Glu Val Gln Leu Val 
            100                 105                 110         


Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser 
        115                 120                 125             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp Val 
    130                 135                 140                 


Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro 
145                 150                 155                 160 


Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu Asp Lys Ala Thr 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser 
            180                 185                 190         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Trp Asn 
        195                 200                 205             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Val Pro Pro Val Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Ser Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala Ser Tyr 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro 
465                 470                 475                 480 


Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp 
                485                 490                 495     


Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr 
            500                 505                 510         


Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr 
        515                 520                 525             


Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys 
    530                 535                 540                 


Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly His Arg Val 
545                 550                 555                 560 


His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr 
                565                 570                 575     


Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Gly Ala Tyr Lys 
            580                 585                 590         


Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe 
        595                 600                 605             


Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp 
    610                 615                 620                 


Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro 
625                 630                 635                 640 


Leu Phe Gly Thr Leu His Pro Ser Phe Tyr Gly Ser Ser Arg Glu Ala 
                645                 650                 655     


Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp 
            660                 665                 670         


Glu Gly Asp Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly Ser Val Gln 
        675                 680                 685             


Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp 
    690                 695                 700                 


Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn 
705                 710                 715                 720 


Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr 
                725                 730                 735     


Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu 
            740                 745                 750         


Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg Asn Pro His 
        755                 760                 765             


His His His His His 
    770             


<210>  47
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h591scFv-Fc67-GTA-his tag

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Pro Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Glu Val Gln Leu Val 
            100                 105                 110         


Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser 
        115                 120                 125             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp Val 
    130                 135                 140                 


Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro 
145                 150                 155                 160 


Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu Asp Lys Ala Thr 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser 
            180                 185                 190         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Trp Asn 
        195                 200                 205             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Val Pro Pro Val Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Ser Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala Ser Tyr 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro 
465                 470                 475                 480 


Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp 
                485                 490                 495     


Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr 
            500                 505                 510         


Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr 
        515                 520                 525             


Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys 
    530                 535                 540                 


Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly His Arg Val 
545                 550                 555                 560 


His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr 
                565                 570                 575     


Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Arg Ala Tyr Lys 
            580                 585                 590         


Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe 
        595                 600                 605             


Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp 
    610                 615                 620                 


Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro 
625                 630                 635                 640 


Leu Phe Gly Thr Leu His Pro Gly Phe Tyr Gly Ser Ser Arg Glu Ala 
                645                 650                 655     


Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp 
            660                 665                 670         


Glu Gly Asp Phe Tyr Tyr Leu Gly Gly Phe Phe Gly Gly Ser Val Gln 
        675                 680                 685             


Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp 
    690                 695                 700                 


Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn 
705                 710                 715                 720 


Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr 
                725                 730                 735     


Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu 
            740                 745                 750         


Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg Asn Pro His 
        755                 760                 765             


His His His His His 
    770             


<210>  48
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591scFv-GTB-Myc-His tag

<400>  48

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ala Ser Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Thr 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Asp Ile Val Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Lys Ala Ser Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His 
        195                 200                 205             


Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Asp Tyr Phe 
225                 230                 235                 240 


Cys Gln Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met 
        275                 280                 285             


Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu 
    290                 295                 300                 


Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn 
305                 310                 315                 320 


Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly 
                325                 330                 335     


Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe 
            340                 345                 350         


Leu Glu Thr Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr 
        355                 360                 365             


Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly 
    370                 375                 380                 


Thr Gly Arg Gln Leu Ser Val Leu Glu Val Gly Ala Tyr Lys Arg Trp 
385                 390                 395                 400 


Gln Asp Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu 
                405                 410                 415     


Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp 
            420                 425                 430         


Met Glu Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe 
        435                 440                 445             


Gly Thr Leu His Pro Ser Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr 
    450                 455                 460                 


Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly 
465                 470                 475                 480 


Asp Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly Ser Val Gln Glu Val 
                485                 490                 495     


Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala 
            500                 505                 510         


Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr 
        515                 520                 525             


Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp 
    530                 535                 540                 


Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe 
545                 550                 555                 560 


Thr Ala Val Pro Lys Asn His Gln Ala Val Arg Asn Pro Ala Ala Ala 
                565                 570                 575     


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Val Glu His 
            580                 585                 590         


His His His His His 
        595         


<210>  49
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591scFv-GTA-Myc-His tag

<400>  49

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Glu Tyr Thr Ile His Trp Val Lys Gln Ala Ser Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Thr 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Asp Ile Val Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Lys Ala Ser Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His 
        195                 200                 205             


Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Asp Tyr Phe 
225                 230                 235                 240 


Cys Gln Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met 
        275                 280                 285             


Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu 
    290                 295                 300                 


Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn 
305                 310                 315                 320 


Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly 
                325                 330                 335     


Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe 
            340                 345                 350         


Leu Glu Thr Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr 
        355                 360                 365             


Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly 
    370                 375                 380                 


Thr Gly Arg Gln Leu Ser Val Leu Glu Val Arg Ala Tyr Lys Arg Trp 
385                 390                 395                 400 


Gln Asp Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu 
                405                 410                 415     


Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp 
            420                 425                 430         


Met Glu Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe 
        435                 440                 445             


Gly Thr Leu His Pro Gly Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr 
    450                 455                 460                 


Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly 
465                 470                 475                 480 


Asp Phe Tyr Tyr Leu Gly Gly Phe Phe Gly Gly Ser Val Gln Glu Val 
                485                 490                 495     


Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala 
            500                 505                 510         


Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr 
        515                 520                 525             


Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp 
    530                 535                 540                 


Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe 
545                 550                 555                 560 


Thr Ala Val Pro Lys Asn His Gln Ala Val Arg Asn Pro Ala Ala Ala 
                565                 570                 575     


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Val Glu His 
            580                 585                 590         


His His His His His 
        595         


<210>  50
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide-4D5 H chain-GTB

<400>  50

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met 
                485                 490                 495     


Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu 
            500                 505                 510         


Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn 
        515                 520                 525             


Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly 
    530                 535                 540                 


Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe 
545                 550                 555                 560 


Leu Glu Thr Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr 
                565                 570                 575     


Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly 
            580                 585                 590         


Thr Gly Arg Gln Leu Ser Val Leu Glu Val Gly Ala Tyr Lys Arg Trp 
        595                 600                 605             


Gln Asp Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu 
    610                 615                 620                 


Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp 
625                 630                 635                 640 


Met Glu Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe 
                645                 650                 655     


Gly Thr Leu His Pro Ser Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr 
            660                 665                 670         


Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly 
        675                 680                 685             


Asp Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly Ser Val Gln Glu Val 
    690                 695                 700                 


Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala 
705                 710                 715                 720 


Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr 
                725                 730                 735     


Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp 
            740                 745                 750         


Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe 
        755                 760                 765             


Thr Ala Val Pro Lys Asn His Gln Ala Val Arg Asn Pro 
    770                 775                 780     


<210>  51
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide-4D5 H chain -GTA

<400>  51

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met 
                485                 490                 495     


Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu 
            500                 505                 510         


Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn 
        515                 520                 525             


Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly 
    530                 535                 540                 


Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe 
545                 550                 555                 560 


Leu Glu Thr Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr 
                565                 570                 575     


Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly 
            580                 585                 590         


Thr Gly Arg Gln Leu Ser Val Leu Glu Val Arg Ala Tyr Lys Arg Trp 
        595                 600                 605             


Gln Asp Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu 
    610                 615                 620                 


Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp 
625                 630                 635                 640 


Met Glu Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe 
                645                 650                 655     


Gly Thr Leu His Pro Gly Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr 
            660                 665                 670         


Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly 
        675                 680                 685             


Asp Phe Tyr Tyr Leu Gly Gly Phe Phe Gly Gly Ser Val Gln Glu Val 
    690                 695                 700                 


Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala 
705                 710                 715                 720 


Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr 
                725                 730                 735     


Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp 
            740                 745                 750         


Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe 
        755                 760                 765             


Thr Ala Val Pro Lys Asn His Gln Ala Val Arg Asn Pro 
    770                 775                 780     


<210>  52
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide- 4D5-LC -his tag

<400>  52

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
        35                  40                  45              


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
            100                 105                 110         


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys His His His His His His 
225                 230                 235                 


<210>  53
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide-4D5Fab-GTB-Myc-his tag

<400>  53

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Glu Pro Asp His Leu Gln Arg Val Ser 
                245                 250                 255     


Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg 
            260                 265                 270         


Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu 
        275                 280                 285             


Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn 
    290                 295                 300                 


Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe 
305                 310                 315                 320 


Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly His 
                325                 330                 335     


Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg 
            340                 345                 350         


Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Gly Ala 
        355                 360                 365             


Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile Ser 
    370                 375                 380                 


Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys 
385                 390                 395                 400 


Val Asp Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile Leu 
                405                 410                 415     


Thr Pro Leu Phe Gly Thr Leu His Pro Ser Phe Tyr Gly Ser Ser Arg 
            420                 425                 430         


Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro 
        435                 440                 445             


Lys Asp Glu Gly Asp Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly Ser 
    450                 455                 460                 


Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met Met 
465                 470                 475                 480 


Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser His 
                485                 490                 495     


Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro 
            500                 505                 510         


Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg 
        515                 520                 525             


Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg Asn 
    530                 535                 540                 


Pro Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
545                 550                 555                 560 


Ala Val Glu His His His His His His 
                565                 


<210>  54
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide-4D5Fab-GTA-Myc-his tag

<400>  54

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Glu Pro Asp His Leu Gln Arg Val Ser 
                245                 250                 255     


Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg 
            260                 265                 270         


Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu 
        275                 280                 285             


Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn 
    290                 295                 300                 


Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe 
305                 310                 315                 320 


Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly His 
                325                 330                 335     


Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg 
            340                 345                 350         


Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Arg Ala 
        355                 360                 365             


Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile Ser 
    370                 375                 380                 


Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys 
385                 390                 395                 400 


Val Asp Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile Leu 
                405                 410                 415     


Thr Pro Leu Phe Gly Thr Leu His Pro Gly Phe Tyr Gly Ser Ser Arg 
            420                 425                 430         


Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro 
        435                 440                 445             


Lys Asp Glu Gly Asp Phe Tyr Tyr Leu Gly Gly Phe Phe Gly Gly Ser 
    450                 455                 460                 


Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met Met 
465                 470                 475                 480 


Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser His 
                485                 490                 495     


Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro 
            500                 505                 510         


Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg 
        515                 520                 525             


Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg Asn 
    530                 535                 540                 


Pro Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
545                 550                 555                 560 


Ala Val Glu His His His His His His 
                565                 


<210>  55
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide- 4D5-LC

<400>  55

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
        35                  40                  45              


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
            100                 105                 110         


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  56
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5HC67-GTB

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met 
                245                 250                 255     


Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu 
            260                 265                 270         


Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn 
        275                 280                 285             


Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly 
    290                 295                 300                 


Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe 
305                 310                 315                 320 


Leu Glu Thr Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr 
                325                 330                 335     


Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly 
            340                 345                 350         


Thr Gly Arg Gln Leu Ser Val Leu Glu Val Gly Ala Tyr Lys Arg Trp 
        355                 360                 365             


Gln Asp Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu 
    370                 375                 380                 


Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp 
385                 390                 395                 400 


Met Glu Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe 
                405                 410                 415     


Gly Thr Leu His Pro Ser Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr 
            420                 425                 430         


Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly 
        435                 440                 445             


Asp Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly Ser Val Gln Glu Val 
    450                 455                 460                 


Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala 
465                 470                 475                 480 


Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr 
                485                 490                 495     


Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp 
            500                 505                 510         


Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe 
        515                 520                 525             


Thr Ala Val Pro Lys Asn His Gln Ala Val Arg Asn Pro 
    530                 535                 540     


<210>  57
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5HC67-GTA

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met 
                245                 250                 255     


Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu 
            260                 265                 270         


Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn 
        275                 280                 285             


Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly 
    290                 295                 300                 


Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe 
305                 310                 315                 320 


Leu Glu Thr Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr 
                325                 330                 335     


Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly 
            340                 345                 350         


Thr Gly Arg Gln Leu Ser Val Leu Glu Val Arg Ala Tyr Lys Arg Trp 
        355                 360                 365             


Gln Asp Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu 
    370                 375                 380                 


Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp 
385                 390                 395                 400 


Met Glu Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe 
                405                 410                 415     


Gly Thr Leu His Pro Gly Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr 
            420                 425                 430         


Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly 
        435                 440                 445             


Asp Phe Tyr Tyr Leu Gly Gly Phe Phe Gly Gly Ser Val Gln Glu Val 
    450                 455                 460                 


Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala 
465                 470                 475                 480 


Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr 
                485                 490                 495     


Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp 
            500                 505                 510         


Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe 
        515                 520                 525             


Thr Ala Val Pro Lys Asn His Gln Ala Val Arg Asn Pro 
    530                 535                 540     


<210>  58
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5-LC-his tag

<400>  58

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His His His His His His 
    210                 215                 220 


<210>  59
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5scFv-Fc67-GTB-his tag

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met Val Tyr 
            260                 265                 270         


Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu Val Val 
        275                 280                 285             


Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn Ile Asp 
    290                 295                 300                 


Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu Thr 
305                 310                 315                 320 


Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu Glu 
                325                 330                 335     


Thr Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr Tyr Val 
            340                 345                 350         


Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly Thr Gly 
        355                 360                 365             


Arg Gln Leu Ser Val Leu Glu Val Gly Ala Tyr Lys Arg Trp Gln Asp 
    370                 375                 380                 


Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu Arg Arg 
385                 390                 395                 400 


Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp Met Glu 
                405                 410                 415     


Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe Gly Thr 
            420                 425                 430         


Leu His Pro Ser Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr Glu 
        435                 440                 445             


Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp Phe 
    450                 455                 460                 


Tyr Tyr Met Gly Ala Phe Phe Gly Gly Ser Val Gln Glu Val Gln Arg 
465                 470                 475                 480 


Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala Asn Gly 
                485                 490                 495     


Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr Leu Leu 
            500                 505                 510         


Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp Gln 
        515                 520                 525             


Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe Thr Ala 
    530                 535                 540                 


Val Pro Lys Asn His Gln Ala Val Arg Asn Pro His His His His His 
545                 550                 555                 560 


His 
    


<210>  60
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5scFv-Fc67-GTA-his tag

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met Val Tyr 
            260                 265                 270         


Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu Val Val 
        275                 280                 285             


Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn Ile Asp 
    290                 295                 300                 


Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu Thr 
305                 310                 315                 320 


Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu Glu 
                325                 330                 335     


Thr Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr Tyr Val 
            340                 345                 350         


Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly Thr Gly 
        355                 360                 365             


Arg Gln Leu Ser Val Leu Glu Val Arg Ala Tyr Lys Arg Trp Gln Asp 
    370                 375                 380                 


Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu Arg Arg 
385                 390                 395                 400 


Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp Met Glu 
                405                 410                 415     


Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe Gly Thr 
            420                 425                 430         


Leu His Pro Gly Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr Glu 
        435                 440                 445             


Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp Phe 
    450                 455                 460                 


Tyr Tyr Leu Gly Gly Phe Phe Gly Gly Ser Val Gln Glu Val Gln Arg 
465                 470                 475                 480 


Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala Asn Gly 
                485                 490                 495     


Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr Leu Leu 
            500                 505                 510         


Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp Gln 
        515                 520                 525             


Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe Thr Ala 
    530                 535                 540                 


Val Pro Lys Asn His Gln Ala Val Arg Asn Pro His His His His His 
545                 550                 555                 560 


His 
    


<210>  61
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5scFv-GTB-Myc-His tag

<400>  61

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
        195                 200                 205             


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro 
        275                 280                 285             


Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp 
    290                 295                 300                 


Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr 
305                 310                 315                 320 


Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr 
                325                 330                 335     


Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys 
            340                 345                 350         


Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly His Arg Val 
        355                 360                 365             


His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr 
    370                 375                 380                 


Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Gly Ala Tyr Lys 
385                 390                 395                 400 


Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe 
                405                 410                 415     


Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp 
            420                 425                 430         


Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro 
        435                 440                 445             


Leu Phe Gly Thr Leu His Pro Ser Phe Tyr Gly Ser Ser Arg Glu Ala 
    450                 455                 460                 


Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp 
465                 470                 475                 480 


Glu Gly Asp Phe Tyr Tyr Met Gly Ala Phe Phe Gly Gly Ser Val Gln 
                485                 490                 495     


Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp 
            500                 505                 510         


Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn 
        515                 520                 525             


Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr 
    530                 535                 540                 


Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu 
545                 550                 555                 560 


Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg Asn Pro Ala 
                565                 570                 575     


Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Val 
            580                 585                 590         


Glu His His His His His His 
        595                 


<210>  62
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5scFv-GTA-Myc-His tag

<400>  62

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
        195                 200                 205             


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro 
        275                 280                 285             


Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp 
    290                 295                 300                 


Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr 
305                 310                 315                 320 


Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr 
                325                 330                 335     


Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys 
            340                 345                 350         


Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly His Arg Val 
        355                 360                 365             


His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr 
    370                 375                 380                 


Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Arg Ala Tyr Lys 
385                 390                 395                 400 


Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe 
                405                 410                 415     


Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp 
            420                 425                 430         


Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile Leu Thr Pro 
        435                 440                 445             


Leu Phe Gly Thr Leu His Pro Gly Phe Tyr Gly Ser Ser Arg Glu Ala 
    450                 455                 460                 


Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp 
465                 470                 475                 480 


Glu Gly Asp Phe Tyr Tyr Leu Gly Gly Phe Phe Gly Gly Ser Val Gln 
                485                 490                 495     


Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met Met Val Asp 
            500                 505                 510         


Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser His Leu Asn 
        515                 520                 525             


Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr 
    530                 535                 540                 


Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu 
545                 550                 555                 560 


Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg Asn Pro Ala 
                565                 570                 575     


Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Val 
            580                 585                 590         


Glu His His His His His His 
        595                 


<210>  63
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IL2 signal peptide-Obexelimab-scFv-Marmoset alpha-1,3 
       galactosyltransferase (aa90-376)-his tag

<400>  63

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Gln Gly Arg Val Thr Ile Ser Ser Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Thr Arg Val Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
                165                 170                 175     


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Lys Ser Leu Gln Asn Val 
            180                 185                 190         


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ser 
        195                 200                 205             


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Asn Ser Gly Val Pro 
    210                 215                 220                 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
225                 230                 235                 240 


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Met Gln His 
                245                 250                 255     


Leu Glu Tyr Pro Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        275                 280                 285             


Leu Arg Leu Trp Asp Trp Phe Asn Pro Lys Lys Arg Pro Glu Val Met 
    290                 295                 300                 


Thr Val Thr Gln Trp Lys Ala Pro Val Val Trp Glu Gly Thr Tyr Asn 
305                 310                 315                 320 


Lys Ala Ile Leu Glu Asn Tyr Tyr Ala Lys Gln Lys Ile Thr Val Gly 
                325                 330                 335     


Leu Thr Val Phe Ala Ile Gly Arg Tyr Ile Glu His Tyr Leu Glu Glu 
            340                 345                 350         


Phe Val Thr Ser Ala Asn Arg Tyr Phe Met Val Gly His Lys Val Ile 
        355                 360                 365             


Phe Tyr Val Met Val Asp Asp Val Ser Lys Ala Pro Phe Ile Glu Leu 
    370                 375                 380                 


Gly Pro Leu Arg Ser Phe Lys Val Phe Glu Val Lys Pro Glu Lys Arg 
385                 390                 395                 400 


Trp Gln Asp Ile Ser Met Met Arg Met Lys Thr Ile Gly Glu His Ile 
                405                 410                 415     


Leu Ala His Ile Gln His Glu Val Asp Phe Leu Phe Cys Met Asp Val 
            420                 425                 430         


Asp Gln Val Phe Gln Asp His Phe Gly Val Glu Thr Leu Gly Gln Ser 
        435                 440                 445             


Val Ala Gln Leu Gln Ala Trp Trp Tyr Lys Ala Asp Pro Asp Asp Phe 
    450                 455                 460                 


Thr Tyr Glu Arg Arg Lys Glu Ser Ala Ala Tyr Ile Pro Phe Gly Gln 
465                 470                 475                 480 


Gly Asp Phe Tyr Tyr His Ala Ala Ile Phe Gly Gly Thr Pro Ile Gln 
                485                 490                 495     


Val Leu Asn Ile Thr Gln Glu Cys Phe Lys Gly Ile Leu Leu Asp Lys 
            500                 505                 510         


Lys Asn Asp Ile Glu Ala Glu Trp His Asp Glu Ser His Leu Asn Lys 
        515                 520                 525             


Tyr Phe Leu Leu Asn Lys Pro Ser Lys Ile Leu Ser Pro Glu Tyr Cys 
    530                 535                 540                 


Trp Asp Tyr His Ile Gly Leu Pro Ser Asp Ile Lys Thr Val Lys Leu 
545                 550                 555                 560 


Ser Trp Gln Thr Lys Glu Tyr Asn Leu Val Arg Lys Asn Val Gly Gly 
                565                 570                 575     


Gly Ser His His His His His His 
            580                 


<210>  64
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  64

Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met Val Tyr Pro 
1               5                   10                  15      


Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu Val Val Thr 
            20                  25                  30          


Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn Ile Asp Ile 
        35                  40                  45              


Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu Thr Val 
    50                  55                  60                  


Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu Glu Thr 
65                  70                  75                  80  


Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr Tyr Val Phe 
                85                  90                  95      


Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly Thr Gly Arg 
            100                 105                 110         


Gln Leu Ser Val Leu Glu Val Arg Ala Tyr Lys Arg Trp Gln Asp Val 
        115                 120                 125             


Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu Arg Arg Phe 
    130                 135                 140                 


Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp Met Glu Phe 
145                 150                 155                 160 


Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe Gly Thr Leu 
                165                 170                 175     


His Pro Gly Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr Glu Arg 
            180                 185                 190         


Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp Phe Tyr 
        195                 200                 205             


Tyr Leu Gly Gly Phe Phe Gly Gly Ser Val Gln Glu Val Gln Arg Leu 
    210                 215                 220                 


Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala Asn Gly Ile 
225                 230                 235                 240 


Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr Leu Leu Arg 
                245                 250                 255     


His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp Gln Gln 
            260                 265                 270         


Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe Thr Ala Val 
        275                 280                 285             


Pro Lys Asn His Gln Ala Val Arg Asn Pro 
    290                 295             


<210>  65
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  65

Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met Val Tyr Pro 
1               5                   10                  15      


Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu Val Val Thr 
            20                  25                  30          


Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn Ile Asp Ile 
        35                  40                  45              


Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu Thr Val 
    50                  55                  60                  


Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu Glu Thr 
65                  70                  75                  80  


Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr Tyr Val Phe 
                85                  90                  95      


Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly Thr Gly Arg 
            100                 105                 110         


Gln Leu Ser Val Leu Glu Val Gly Ala Tyr Lys Arg Trp Gln Asp Val 
        115                 120                 125             


Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu Arg Arg Phe 
    130                 135                 140                 


Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp Met Glu Phe 
145                 150                 155                 160 


Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe Gly Thr Leu 
                165                 170                 175     


His Pro Ser Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr Glu Arg 
            180                 185                 190         


Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp Phe Tyr 
        195                 200                 205             


Tyr Met Gly Ala Phe Phe Gly Gly Ser Val Gln Glu Val Gln Arg Leu 
    210                 215                 220                 


Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala Asn Gly Ile 
225                 230                 235                 240 


Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr Leu Leu Arg 
                245                 250                 255     


His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp Gln Gln 
            260                 265                 270         


Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe Thr Ala Val 
        275                 280                 285             


Pro Lys Asn His Gln Ala Val Arg Asn 
    290                 295         


<210>  66
<211>  291
<212>  PRT
<213>  Unknown

<220>
<223>  Protein

<400>  66

Glu Leu Arg Leu Trp Asp Trp Phe Asn Pro Lys Lys Arg Pro Glu Val 
1               5                   10                  15      


Met Thr Val Thr Gln Trp Lys Ala Pro Val Val Trp Glu Gly Thr Tyr 
            20                  25                  30          


Asn Lys Ala Ile Leu Glu Asn Tyr Tyr Ala Lys Gln Lys Ile Thr Val 
        35                  40                  45              


Gly Leu Thr Val Phe Ala Ile Gly Arg Tyr Ile Glu His Tyr Leu Glu 
    50                  55                  60                  


Glu Phe Val Thr Ser Ala Asn Arg Tyr Phe Met Val Gly His Lys Val 
65                  70                  75                  80  


Ile Phe Tyr Val Met Val Asp Asp Val Ser Lys Ala Pro Phe Ile Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg Ser Phe Lys Val Phe Glu Val Lys Pro Glu Lys 
            100                 105                 110         


Arg Trp Gln Asp Ile Ser Met Met Arg Met Lys Thr Ile Gly Glu His 
        115                 120                 125             


Ile Leu Ala His Ile Gln His Glu Val Asp Phe Leu Phe Cys Met Asp 
    130                 135                 140                 


Val Asp Gln Val Phe Gln Asp His Phe Gly Val Glu Thr Leu Gly Gln 
145                 150                 155                 160 


Ser Val Ala Gln Leu Gln Ala Trp Trp Tyr Lys Ala Asp Pro Asp Asp 
                165                 170                 175     


Phe Thr Tyr Glu Arg Arg Lys Glu Ser Ala Ala Tyr Ile Pro Phe Gly 
            180                 185                 190         


Gln Gly Asp Phe Tyr Tyr His Ala Ala Ile Phe Gly Gly Thr Pro Ile 
        195                 200                 205             


Gln Val Leu Asn Ile Thr Gln Glu Cys Phe Lys Gly Ile Leu Leu Asp 
    210                 215                 220                 


Lys Lys Asn Asp Ile Glu Ala Glu Trp His Asp Glu Ser His Leu Asn 
225                 230                 235                 240 


Lys Tyr Phe Leu Leu Asn Lys Pro Ser Lys Ile Leu Ser Pro Glu Tyr 
                245                 250                 255     


Cys Trp Asp Tyr His Ile Gly Leu Pro Ser Asp Ile Lys Thr Val Lys 
            260                 265                 270         


Leu Ser Trp Gln Thr Lys Glu Tyr Asn Leu Val Arg Lys Asn Val Gly 
        275                 280                 285             


Gly Gly Ser 
    290     


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  67

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  68
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591 heavy chain

<400>  68

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  69
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  69

Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met Val Tyr Pro 
1               5                   10                  15      


Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu Val Val Thr 
            20                  25                  30          


Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn Ile Asp Ile 
        35                  40                  45              


Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu Thr Val 
    50                  55                  60                  


Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu Glu Thr 
65                  70                  75                  80  


Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr Tyr Val Phe 
                85                  90                  95      


Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly Thr Gly Arg 
            100                 105                 110         


Gln Leu Ser Val Leu Glu Val Gly Ala Tyr Lys Arg Trp Gln Asp Val 
        115                 120                 125             


Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu Arg Arg Phe 
    130                 135                 140                 


Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp Met Glu Phe 
145                 150                 155                 160 


Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe Gly Thr Leu 
                165                 170                 175     


His Pro Ser Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr Glu Arg 
            180                 185                 190         


Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp Phe Tyr 
        195                 200                 205             


Tyr Met Gly Ala Phe Phe Gly Gly Ser Val Gln Glu Val Gln Arg Leu 
    210                 215                 220                 


Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala Asn Gly Ile 
225                 230                 235                 240 


Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr Leu Leu Arg 
                245                 250                 255     


His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp Gln Gln 
            260                 265                 270         


Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe Thr Ala Val 
        275                 280                 285             


Pro Lys Asn His Gln Ala Val Arg Asn Pro 
    290                 295             


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6 his tag

<400>  70

His His His His His His 
1               5       


<210>  71
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591-LC

<400>  71

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Pro Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  72
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591 heavy chain

<400>  72

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220             


<210>  73
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc-his tag

<400>  73

Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala 
1               5                   10                  15      


Val Glu His His His His His His 
            20                  


<210>  74
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591 heavy chain

<400>  74

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Val 
    210                 215                 220                 


Pro Pro Val Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Val Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Arg Leu Ala Ser Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  75
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54aa tail

<400>  75

Glu Phe Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser Ala Asp 
1               5                   10                  15      


Ile His His Thr Gly Ala Arg Ser Ser Ala His Leu Glu Leu Thr Ala 
            20                  25                  30          


Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
        35                  40                  45              


Lys Asp Asp Asp Asp Lys 
    50                  


<210>  76
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591scFv/Fc

<400>  76

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Pro Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Glu Val Gln Leu Val 
            100                 105                 110         


Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser 
        115                 120                 125             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp Val 
    130                 135                 140                 


Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro 
145                 150                 155                 160 


Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu Asp Lys Ala Thr 
                165                 170                 175     


Leu Thr Val Asp Lys Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser 
            180                 185                 190         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Trp Asn 
        195                 200                 205             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Val Pro Pro Val Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Ser Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala Ser Tyr 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  77
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huJ591scFv

<400>  77

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ala Ser Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
145                 150                 155                 160 


Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Asp Tyr Phe Cys Gln Gln Tyr 
    210                 215                 220                 


Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 


<210>  78
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  78

Glu Pro Asp His Leu Gln Arg Val Ser Leu Pro Arg Met Val Tyr Pro 
1               5                   10                  15      


Gln Pro Lys Val Leu Thr Pro Cys Arg Lys Asp Val Leu Val Val Thr 
            20                  25                  30          


Pro Trp Leu Ala Pro Ile Val Trp Glu Gly Thr Phe Asn Ile Asp Ile 
        35                  40                  45              


Leu Asn Glu Gln Phe Arg Leu Gln Asn Thr Thr Ile Gly Leu Thr Val 
    50                  55                  60                  


Phe Ala Ile Lys Lys Tyr Val Ala Phe Leu Lys Leu Phe Leu Glu Thr 
65                  70                  75                  80  


Ala Glu Lys His Phe Met Val Gly His Arg Val His Tyr Tyr Val Phe 
                85                  90                  95      


Thr Asp Gln Pro Ala Ala Val Pro Arg Val Thr Leu Gly Thr Gly Arg 
            100                 105                 110         


Gln Leu Ser Val Leu Glu Val Arg Ala Tyr Lys Arg Trp Gln Asp Val 
        115                 120                 125             


Ser Met Arg Arg Met Glu Met Ile Ser Asp Phe Cys Glu Arg Arg Phe 
    130                 135                 140                 


Leu Ser Glu Val Asp Tyr Leu Val Cys Val Asp Val Asp Met Glu Phe 
145                 150                 155                 160 


Arg Asp His Val Gly Val Glu Ile Leu Thr Pro Leu Phe Gly Thr Leu 
                165                 170                 175     


His Pro Gly Phe Tyr Gly Ser Ser Arg Glu Ala Phe Thr Tyr Glu Arg 
            180                 185                 190         


Arg Pro Gln Ser Gln Ala Tyr Ile Pro Lys Asp Glu Gly Asp Phe Tyr 
        195                 200                 205             


Tyr Leu Gly Gly Phe Phe Gly Gly Ser Val Gln Glu Val Gln Arg Leu 
    210                 215                 220                 


Thr Arg Ala Cys His Gln Ala Met Met Val Asp Gln Ala Asn Gly Ile 
225                 230                 235                 240 


Glu Ala Val Trp His Asp Glu Ser His Leu Asn Lys Tyr Leu Leu Arg 
                245                 250                 255     


His Lys Pro Thr Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp Gln Gln 
            260                 265                 270         


Leu Leu Gly Trp Pro Ala Val Leu Arg Lys Leu Arg Phe Thr Ala Val 
        275                 280                 285             


Pro Lys Asn His Gln Ala Val Arg Asn Pro 
    290                 295             


<210>  79
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab (4D5) Heavy Chain

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  80
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab (4D5) Light Chain

<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  81
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab (4D5) scFv

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


