                               SEQUENCE LISTING

<110> RAYZEBIO, INC.
 
<120> RADIOPHARMACEUTICAL CONJUGATES TARGETING GUANYLYL CYCLASE C, AND 
      COMPOSITIONS AND USES THEREOF

<130> 59541-708.601

<140>
<141>

<150> 63/119,557
<151> 2020-11-30

<160> 51    

<170> PatentIn version 3.5

<210> 1
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  


<210> 2
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  


<210> 3
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Asn Ser Ser Asn Tyr Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr 
1               5                   10                  15      


Gly Cys Tyr 
            


<210> 4
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Ser His Thr Cys Glu Ile Cys Ala Phe Ala Ala Cys Ala Gly Cys 
1               5                   10                  15  


<210> 5
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Gln Glu Asp Cys Glu Leu Cys Ile Asn Val Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210> 6
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Gln Glu Glu Cys Glu Leu Cys Ile Asn Met Ala Cys Thr Gly Tyr 
1               5                   10                  15  


<210> 7
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Ser Ser Asn Tyr Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr Gly 
1               5                   10                  15      


Cys Phe 
        


<210> 8
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Asn Thr Phe Tyr Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr Gly 
1               5                   10                  15      


Cys Tyr 
        


<210> 9
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ala Ser Ser Tyr Ala Ser Cys Ile Trp Cys Thr Thr Ala Cys Ala Ser 
1               5                   10                  15      


Cys His Gly 
            


<210> 10
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Gly Asn Leu Ile Asp Cys Cys Glu Ile Cys Cys Asn Pro Ala Cys Phe 
1               5                   10                  15      


Gly Cys Leu Asn 
            20  


<210> 11
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Gly Asn Leu Ile Asp Arg Cys Glu Ile Cys Cys Asn Pro Ala Cys Phe 
1               5                   10                  15      


Gly Cys Leu Asn 
            20  


<210> 12
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Ser Ser Asp Trp Asp Cys Cys Asp Val Cys Cys Asn Pro Ala Cys Ala 
1               5                   10                  15      


Gly Cys 
        


<210> 13
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Pro Gly Thr Cys Glu Ile Cys Ala Tyr Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210> 14
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Asn Asp Asp Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu 
1               5                   10                  15      


<210> 15
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Asn Ser Ser Asn Tyr Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr 
1               5                   10                  15      


Gly Cys Phe 
            


<210> 16
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Arg Ser Ser Arg Tyr Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr 
1               5                   10                  15      


Gly Cys Phe 
            


<210> 17
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Cys Cys Glu Phe Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  


<210> 18
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Asn Asp Glu Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu 
1               5                   10                  15      


<210> 19
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> May or may not be a D-amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> May or may not be a D-amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 19
Asn Asp Glu Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu 
1               5                   10                  15      


<210> 20
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  


<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Cys Glu Ile Cys Ala Phe Ala Ala Cys Ala Gly Cys 
1               5                   10          


<210> 22
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Cys Glu Leu Cys Ile Asn Val Ala Cys Thr Gly Cys 
1               5                   10          


<210> 23
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Cys Glu Leu Cys Ile Asn Met Ala Cys Thr Gly Tyr 
1               5                   10          


<210> 24
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr Gly Cys Phe 
1               5                   10                  


<210> 25
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Ser Cys Ile Trp Cys Thr Thr Ala Cys Ala Ser Cys His Gly 
1               5                   10                  


<210> 26
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Cys Cys Glu Ile Cys Cys Asn Pro Ala Cys Phe Gly Cys Leu Asn 
1               5                   10                  15  


<210> 27
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Arg Cys Glu Ile Cys Cys Asn Pro Ala Cys Phe Gly Cys Leu Asn 
1               5                   10                  15  


<210> 28
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Cys Cys Asp Val Cys Cys Asn Pro Ala Cys Ala Gly Cys 
1               5                   10              


<210> 29
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Cys Glu Ile Cys Ala Tyr Ala Ala Cys Thr Gly Cys 
1               5                   10          


<210> 30
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu 
1               5                   10              


<210> 31
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (8)..(8)
<223> 3,4-dehydro-proline

<400> 31
Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Ala Gly Cys Tyr 
1               5                   10                  


<210> 32
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Cys Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu 
1               5                   10                  


<210> 33
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys 
1               5                   10              


<210> 34
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> May or may not be a D-amino acid

<400> 34
Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Lys 
1               5                   10                  


<210> 35
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> N-Me-Tyr

<400> 35
Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  


<210> 36
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Tyr-NH2

<400> 36
Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  


<210> 37
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> May or may not be a D-amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> May or may not be a D-amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 37
Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr Lys 
1               5                   10                  15  


<210> 38
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Alpha-Me-Tyr

<400> 38
Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  


<210> 39
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> May or may not be a D-amino acid

<400> 39
Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  


<210> 40
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Gly 
1               5                   10                  


<210> 41
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<221> MOD_RES
<222> (1)..(1)
<223> 3,4-dehydro-proline

<400> 41
Pro Gly Thr Cys Glu Ile Cys Ala Tyr Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210> 42
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Pro Gly Trp Cys Glu Ile Cys Ala Tyr Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210> 43
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 43
Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln 
1               5                   10                  15      


Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn 
            20                  25                  30          


Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala 
        35                  40                  45              


Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile 
    50                  55                  60                  


Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala 
65                  70                  75                  80  


Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg 
                85                  90                  95      


Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala 
            100                 105                 110         


Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr 
        115                 120                 125             


Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala 
    130                 135                 140                 


Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu 
145                 150                 155                 160 


Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys 
                165                 170                 175     


Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val 
            180                 185                 190         


Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala 
        195                 200                 205             


Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val 
    210                 215                 220                 


Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn 
225                 230                 235                 240 


Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr 
                245                 250                 255     


Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu 
            260                 265                 270         


Val Asp Leu Phe Asn Asp Gln Tyr Phe Glu Asp Asn Val Thr Ala Pro 
        275                 280                 285             


Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser 
    290                 295                 300                 


Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp 
305                 310                 315                 320 


Phe Ala Leu Ala Tyr Leu Asn Gly Ile Leu Leu Phe Gly His Met Leu 
                325                 330                 335     


Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala 
            340                 345                 350         


His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr 
        355                 360                 365             


Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr 
    370                 375                 380                 


Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His 
385                 390                 395                 400 


Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys 
                405                 410                 415     


Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro Gln Ile Leu 
            420                 425                 430         


Met Ile Ala Val Phe Thr Leu Thr Gly Ala Val Val Leu Leu Leu Leu 
        435                 440                 445             


Val Ala Leu Leu Met Leu Arg Lys Tyr Arg Lys Asp Tyr Glu Leu Arg 
    450                 455                 460                 


Gln Lys Lys Trp Ser His Ile Pro Pro Glu Asn Ile Phe Pro Leu Glu 
465                 470                 475                 480 


Thr Asn Glu Thr Asn His Val Ser Leu Lys Ile Asp Asp Asp Lys Arg 
                485                 490                 495     


Arg Asp Thr Ile Gln Arg Leu Arg Gln Cys Lys Tyr Asp Lys Lys Arg 
            500                 505                 510         


Val Ile Leu Lys Asp Leu Lys His Asn Asp Gly Asn Phe Thr Glu Lys 
        515                 520                 525             


Gln Lys Ile Glu Leu Asn Lys Leu Leu Gln Ile Asp Tyr Tyr Asn Leu 
    530                 535                 540                 


Thr Lys Phe Tyr Gly Thr Val Lys Leu Asp Thr Met Ile Phe Gly Val 
545                 550                 555                 560 


Ile Glu Tyr Cys Glu Arg Gly Ser Leu Arg Glu Val Leu Asn Asp Thr 
                565                 570                 575     


Ile Ser Tyr Pro Asp Gly Thr Phe Met Asp Trp Glu Phe Lys Ile Ser 
            580                 585                 590         


Val Leu Tyr Asp Ile Ala Lys Gly Met Ser Tyr Leu His Ser Ser Lys 
        595                 600                 605             


Thr Glu Val His Gly Arg Leu Lys Ser Thr Asn Cys Val Val Asp Ser 
    610                 615                 620                 


Arg Met Val Val Lys Ile Thr Asp Phe Gly Cys Asn Ser Ile Leu Pro 
625                 630                 635                 640 


Pro Lys Lys Asp Leu Trp Thr Ala Pro Glu His Leu Arg Gln Ala Asn 
                645                 650                 655     


Ile Ser Gln Lys Gly Asp Val Tyr Ser Tyr Gly Ile Ile Ala Gln Glu 
            660                 665                 670         


Ile Ile Leu Arg Lys Glu Thr Phe Tyr Thr Leu Ser Cys Arg Asp Arg 
        675                 680                 685             


Asn Glu Lys Ile Phe Arg Val Glu Asn Ser Asn Gly Met Lys Pro Phe 
    690                 695                 700                 


Arg Pro Asp Leu Phe Leu Glu Thr Ala Glu Glu Lys Glu Leu Glu Val 
705                 710                 715                 720 


Tyr Leu Leu Val Lys Asn Cys Trp Glu Glu Asp Pro Glu Lys Arg Pro 
                725                 730                 735     


Asp Phe Lys Lys Ile Glu Thr Thr Leu Ala Lys Ile Phe Gly Leu Phe 
            740                 745                 750         


His Asp Gln Lys Asn Glu Ser Tyr Met Asp Thr Leu Ile Arg Arg Leu 
        755                 760                 765             


Gln Leu Tyr Ser Arg Asn Leu Glu His Leu Val Glu Glu Arg Thr Gln 
    770                 775                 780                 


Leu Tyr Lys Ala Glu Arg Asp Arg Ala Asp Arg Leu Asn Phe Met Leu 
785                 790                 795                 800 


Leu Pro Arg Leu Val Val Lys Ser Leu Lys Glu Lys Gly Phe Val Glu 
                805                 810                 815     


Pro Glu Leu Tyr Glu Glu Val Thr Ile Tyr Phe Ser Asp Ile Val Gly 
            820                 825                 830         


Phe Thr Thr Ile Cys Lys Tyr Ser Thr Pro Met Glu Val Val Asp Met 
        835                 840                 845             


Leu Asn Asp Ile Tyr Lys Ser Phe Asp His Ile Val Asp His His Asp 
    850                 855                 860                 


Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Ala Ser Gly 
865                 870                 875                 880 


Leu Pro Lys Arg Asn Gly Asn Arg His Ala Ile Asp Ile Ala Lys Met 
                885                 890                 895     


Ala Leu Glu Ile Leu Ser Phe Met Gly Thr Phe Glu Leu Glu His Leu 
            900                 905                 910         


Pro Gly Leu Pro Ile Trp Ile Arg Ile Gly Val His Ser Gly Pro Cys 
        915                 920                 925             


Ala Ala Gly Val Val Gly Ile Lys Met Pro Arg Tyr Cys Leu Phe Gly 
    930                 935                 940                 


Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser Thr Gly Leu Pro Leu 
945                 950                 955                 960 


Arg Ile His Val Ser Gly Ser Thr Ile Ala Ile Leu Lys Arg Thr Glu 
                965                 970                 975     


Cys Gln Phe Leu Tyr Glu Val Arg Gly Glu Thr Tyr Leu Lys Gly Arg 
            980                 985                 990         


Gly Asn Glu Thr Thr Tyr Trp Leu  Thr Gly Met Lys Asp  Gln Lys Phe 
        995                 1000                 1005             


Asn Leu  Pro Thr Pro Pro Thr  Val Glu Asn Gln Gln  Arg Leu Gln 
    1010                 1015                 1020             


Ala Glu  Phe Ser Asp Met Ile  Ala Asn Ser Leu Gln  Lys Arg Gln 
    1025                 1030                 1035             


Ala Ala  Gly Ile Arg Ser Gln  Lys Pro Arg Arg Val  Ala Ser Tyr 
    1040                 1045                 1050             


Lys Lys  Gly Thr Leu Glu Tyr  Leu Gln Leu Asn Thr  Thr Asp Lys 
    1055                 1060                 1065             


Glu Ser  Thr Tyr Phe 
    1070             


<210> 44
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Asn Thr Phe Tyr Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Ala Gly 
1               5                   10                  15      


Cys Tyr 
        


<210> 45
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Glu Ala Ala Ala Lys 
1               5   


<210> 46
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (3)..(3)
<223> OtBu-Glu

<220>
<221> MOD_RES
<222> (4)..(4)
<223> tBu-Tyr

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Trt-Asn

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (11)..(11)
<223> tBu-Thr

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (14)..(14)
<223> tBu-Tyr

<400> 46
Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  


<210> 47
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> 6-aminohexanoic acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (4)..(4)
<223> OtBu-Glu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> tBu-Tyr

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Trt-Asn

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (12)..(12)
<223> tBu-Thr

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (15)..(15)
<223> tBu-Tyr

<400> 47
Xaa Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  15  


<210> 48
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> 6-aminohexanoic acid

<400> 48
Xaa Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  15  


<210> 49
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Dde-Lys

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (4)..(4)
<223> OtBu-Glu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> tBu-Tyr

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Trt-Asn

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Trt-Thr

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (15)..(15)
<223> tBu-Tyr

<400> 49
Lys Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  15  


<210> 50
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (4)..(4)
<223> OtBu-Glu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> tBu-Tyr

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Trt-Asn

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Trt-Thr

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Trt-Cys

<220>
<221> MOD_RES
<222> (15)..(15)
<223> tBu-Tyr

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 50
Lys Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  15  


<210> 51
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 51
Lys Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr 
1               5                   10                  15  


