﻿                         序列表

<110>  中国科学院天津工业生物技术研究所

<120>  一种乙醇酸在酶的作用下生成目标产物的方法

<160>  10

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  400
<212>  PRT
<213>  大肠杆菌(Escherichia coli)

<400>  1
Met Ser Ser Lys Leu Val Leu Val Leu Asn Cys Gly Ser Ser Ser Leu 
1               5                   10                  15      
Lys Phe Ala Ile Ile Asp Ala Val Asn Gly Asp Glu Tyr Leu Ser Gly 
            20                  25                  30          
Leu Ala Glu Cys Phe His Leu Pro Glu Ala Arg Ile Lys Trp Lys Met 
        35                  40                  45              
Asp Gly Ser Lys Gln Glu Ala Ala Leu Gly Ala Gly Ala Ala His Ser 
    50                  55                  60                  
Glu Ala Leu Asn Phe Ile Val Asn Thr Ile Leu Ala Gln Lys Pro Glu 
65                  70                  75                  80  
Leu Ser Ala Gln Leu Thr Ala Ile Gly His Arg Ile Val His Gly Gly 
                85                  90                  95      
Glu Lys Tyr Thr Ser Ser Val Val Ile Asp Glu Ser Val Ile Gln Gly 
            100                 105                 110         
Ile Lys Asp Ser Ala Ser Phe Ala Pro Leu His Asn Pro Ala His Leu 
        115                 120                 125             
Ile Gly Ile Ala Glu Ala Leu Lys Ser Phe Pro Gln Leu Lys Asp Lys 
    130                 135                 140                 
Asn Val Ala Val Phe Asp Thr Ala Phe His Gln Thr Met Pro Glu Glu 
145                 150                 155                 160 
Ser Tyr Leu Tyr Ala Leu Pro Tyr Ser Leu Tyr Lys Glu His Gly Val 
                165                 170                 175     
Arg Arg Tyr Gly Ala His Gly Thr Ser His Phe Tyr Val Thr Gln Glu 
            180                 185                 190         
Ala Ala Lys Met Leu Asn Lys Pro Val Glu Glu Leu Asn Ile Ile Thr 
        195                 200                 205             
Cys His Leu Gly Asn Gly Gly Ser Val Ser Ala Ile Arg Asn Gly Lys 
    210                 215                 220                 
Cys Val Asp Thr Ser Met Gly Leu Thr Pro Leu Glu Gly Leu Val Met 
225                 230                 235                 240 
Gly Thr Arg Ser Gly Asp Ile Asp Pro Ala Ile Ile Phe His Leu His 
                245                 250                 255     
Asp Thr Leu Gly Met Ser Val Asp Gln Ile Asn Lys Met Leu Thr Lys 
            260                 265                 270         
Glu Ser Gly Leu Leu Gly Leu Thr Glu Val Thr Ser Asp Cys Arg Tyr 
        275                 280                 285             
Val Glu Asp Asn Tyr Ala Thr Lys Glu Asp Ala Lys Arg Ala Met Asp 
    290                 295                 300                 
Val Tyr Cys His Arg Leu Ala Lys Tyr Ile Gly Ser Tyr Thr Ala Leu 
305                 310                 315                 320 
Met Asp Gly Arg Leu Asp Ala Val Val Phe Thr Gly Gly Ile Gly Glu 
                325                 330                 335     
Asn Ala Ala Met Val Arg Glu Leu Ser Leu Gly Lys Leu Gly Val Leu 
            340                 345                 350         
Gly Phe Glu Val Asp His Glu Arg Asn Leu Ala Ala Arg Phe Gly Lys 
        355                 360                 365             
Ser Gly Phe Ile Asn Lys Glu Gly Thr Arg Pro Ala Val Val Ile Pro 
    370                 375                 380                 
Thr Asn Glu Glu Leu Val Ile Ala Gln Asp Ala Ser Arg Leu Thr Ala 
385                 390                 395                 400 

<210>  2
<211>  717
<212>  PRT
<213>  大肠杆菌(Escherichia coli)

<400>  2
Met Ala Ser Val Ser Arg Ile Ile Met Leu Ile Pro Thr Gly Thr Ser 
1               5                   10                  15      
Val Gly Leu Thr Ser Val Ser Leu Gly Val Ile Arg Ala Met Glu Arg 
            20                  25                  30          
Lys Gly Val Arg Leu Ser Val Phe Lys Pro Ile Ala Gln Pro Arg Thr 
        35                  40                  45              
Gly Gly Asp Ala Pro Asp Gln Thr Thr Thr Ile Val Arg Ala Asn Ser 
    50                  55                  60                  
Ser Thr Thr Thr Ala Ala Glu Pro Leu Lys Met Ser Tyr Val Glu Gly 
65                  70                  75                  80  
Leu Leu Ser Ser Asn Gln Lys Asp Val Leu Met Glu Glu Ile Val Ala 
                85                  90                  95      
Asn Tyr His Ala Asn Thr Lys Asp Ala Glu Val Val Leu Val Glu Gly 
            100                 105                 110         
Leu Val Pro Thr Arg Lys His Gln Phe Ala Gln Ser Leu Asn Tyr Glu 
        115                 120                 125             
Ile Ala Lys Thr Leu Asn Ala Glu Ile Val Phe Val Met Ser Gln Gly 
    130                 135                 140                 
Thr Asp Thr Pro Glu Gln Leu Lys Glu Arg Ile Glu Leu Thr Arg Asn 
145                 150                 155                 160 
Ser Phe Gly Gly Ala Lys Asn Thr Asn Ile Thr Gly Val Ile Val Asn 
                165                 170                 175     
Lys Leu Asn Ala Pro Val Asp Glu Gln Gly Arg Thr Arg Pro Asp Leu 
            180                 185                 190         
Ser Glu Ile Phe Asp Asp Ser Ser Lys Ala Lys Val Asn Asn Val Asp 
        195                 200                 205             
Pro Ala Lys Leu Gln Glu Ser Ser Pro Leu Pro Val Leu Gly Ala Val 
    210                 215                 220                 
Pro Trp Ser Phe Asp Leu Ile Ala Thr Arg Ala Ile Asp Met Ala Arg 
225                 230                 235                 240 
His Leu Asn Ala Thr Ile Ile Asn Glu Gly Asp Ile Asn Thr Arg Arg 
                245                 250                 255     
Val Lys Ser Val Thr Phe Cys Ala Arg Ser Ile Pro His Met Leu Glu 
            260                 265                 270         
His Phe Arg Ala Gly Ser Leu Leu Val Thr Ser Ala Asp Arg Pro Asp 
        275                 280                 285             
Val Leu Val Ala Ala Cys Leu Ala Ala Met Asn Gly Val Glu Ile Gly 
    290                 295                 300                 
Ala Leu Leu Leu Thr Gly Gly Tyr Glu Met Asp Ala Arg Ile Ser Lys 
305                 310                 315                 320 
Leu Cys Glu Arg Ala Phe Ala Thr Gly Leu Pro Val Phe Met Val Asn 
                325                 330                 335     
Thr Asn Thr Trp Gln Thr Ser Leu Ser Leu Gln Ser Phe Asn Leu Glu 
            340                 345                 350         
Val Pro Val Asp Asp His Glu Arg Ile Glu Lys Val Gln Glu Tyr Val 
        355                 360                 365             
Ala Asn Tyr Ile Asn Ala Asp Trp Ile Glu Ser Leu Thr Ala Thr Ser 
    370                 375                 380                 
Glu Arg Ser Arg Arg Leu Ser Pro Pro Ala Phe Arg Tyr Gln Leu Thr 
385                 390                 395                 400 
Glu Leu Ala Arg Lys Ala Gly Lys Arg Ile Val Leu Pro Glu Gly Asp 
                405                 410                 415     
Glu Pro Arg Thr Val Lys Ala Ala Ala Ile Cys Ala Glu Arg Gly Ile 
            420                 425                 430         
Ala Thr Cys Val Leu Leu Gly Asn Pro Ala Glu Ile Asn Arg Val Ala 
        435                 440                 445             
Ala Ser Gln Gly Val Glu Leu Gly Ala Gly Ile Glu Ile Val Asp Pro 
    450                 455                 460                 
Glu Val Val Arg Glu Ser Tyr Val Gly Arg Leu Val Glu Leu Arg Lys 
465                 470                 475                 480 
Asn Lys Gly Met Thr Glu Thr Val Ala Arg Glu Gln Leu Glu Asp Asn 
                485                 490                 495     
Val Val Leu Gly Thr Leu Met Leu Glu Gln Asp Glu Val Asp Gly Leu 
            500                 505                 510         
Val Ser Gly Ala Val His Thr Thr Ala Asn Thr Ile Arg Pro Pro Leu 
        515                 520                 525             
Gln Leu Ile Lys Thr Ala Pro Gly Ser Ser Leu Val Ser Ser Val Phe 
    530                 535                 540                 
Phe Met Leu Leu Pro Glu Gln Val Tyr Val Tyr Gly Asp Cys Ala Ile 
545                 550                 555                 560 
Asn Pro Asp Pro Thr Ala Glu Gln Leu Ala Glu Ile Ala Ile Gln Ser 
                565                 570                 575     
Ala Asp Ser Ala Ala Ala Phe Gly Ile Glu Pro Arg Val Ala Met Leu 
            580                 585                 590         
Ser Tyr Ser Thr Gly Thr Ser Gly Ala Gly Ser Asp Val Glu Lys Val 
        595                 600                 605             
Arg Glu Ala Thr Arg Leu Ala Gln Glu Lys Arg Pro Asp Leu Met Ile 
    610                 615                 620                 
Asp Gly Pro Leu Gln Tyr Asp Ala Ala Val Met Ala Asp Val Ala Lys 
625                 630                 635                 640 
Ser Lys Ala Pro Asn Ser Pro Val Ala Gly Arg Ala Thr Val Phe Ile 
                645                 650                 655     
Phe Pro Asp Leu Asn Thr Gly Asn Thr Thr Tyr Lys Ala Val Gln Arg 
            660                 665                 670         
Ser Ala Asp Leu Ile Ser Ile Gly Pro Met Leu Gln Gly Met Arg Lys 
        675                 680                 685             
Pro Val Asn Asp Leu Ser Arg Gly Ala Leu Val Asp Asp Ile Val Tyr 
    690                 695                 700                 
Thr Ile Ala Leu Thr Ala Ile Gln Ser Ala Gln Gln Gln 
705                 710                 715         

<210>  3
<211>  522
<212>  PRT
<213>  假单胞菌(Pseudomonas aeruginosa)

<400>  3
Met Ala His His His His His His Val Gly Thr Asn Asp Ala Asn Ile 
1               5                   10                  15      
Ala Asp Val Val Thr Lys Val Leu Gly Glu Tyr Gly Ala Pro Gly Ala 
            20                  25                  30          
Val Ser Val Ala Ala Leu Thr Ala Lys Ser Pro Asp Gly Lys Ser Asn 
        35                  40                  45              
Ser Ser Ala Asp Ala Asp Val Val Ala Arg Met Val Ala Lys Ala Ile 
    50                  55                  60                  
Arg Asp His Ala Gly Thr Ala Gln Pro Ser Gly Asn Ala Ala Thr Ser 
65                  70                  75                  80  
Ser Ala Ala Val Ser Asp Gly Val Phe Glu Thr Met Asp Ala Ala Val 
                85                  90                  95      
Glu Ala Ala Ala Leu Ala Gln Gln Gln Tyr Leu Leu Cys Ser Met Ser 
            100                 105                 110         
Asp Arg Ala Arg Phe Val Gln Gly Ile Arg Asp Val Ile Leu Asn Gln 
        115                 120                 125             
Asp Thr Leu Glu Lys Met Ser Arg Met Ala Val Glu Glu Thr Gly Met 
    130                 135                 140                 
Gly Asn Tyr Glu His Lys Leu Ile Lys Asn Arg Leu Ala Gly Glu Lys 
145                 150                 155                 160 
Thr Pro Gly Ile Glu Asp Leu Thr Thr Asp Ala Phe Ser Gly Asp Asn 
                165                 170                 175     
Gly Leu Thr Leu Val Glu Tyr Ser Pro Phe Gly Val Ile Gly Ala Ile 
            180                 185                 190         
Thr Pro Thr Thr Asn Pro Thr Glu Thr Ile Val Cys Asn Ser Ile Gly 
        195                 200                 205             
Met Leu Ala Ala Gly Asn Ser Val Val Phe Ser Pro His Gly Arg Ala 
    210                 215                 220                 
Arg Gln Val Ser Leu Leu Leu Val Arg Leu Ile Asn Gln Lys Leu Ala 
225                 230                 235                 240 
Ala Leu Gly Ala Pro Glu Asn Leu Val Val Thr Val Glu Lys Pro Ser 
                245                 250                 255     
Arg Glu Asn Thr Leu Ala Met Met Ala His Pro Lys Val Arg Met Leu 
            260                 265                 270         
Val Ala Thr Gly Gly Pro Ala Leu Val Lys Ala Val Leu Ser Thr Gly 
        275                 280                 285             
Lys Lys Ala Ile Gly Ala Gly Ala Gly Asn Pro Pro Val Val Val Asp 
    290                 295                 300                 
Glu Thr Ala Asn Ile Glu Lys Ala Ala Cys Asp Ile Val Asn Gly Cys 
305                 310                 315                 320 
Ser Phe Asp Asn Asn Ile Thr Cys Thr Ala Glu Lys Glu Ile Ile Ala 
                325                 330                 335     
Val Ala Gln Ile Ala Asp Tyr Leu Ile Phe Asn Leu Lys Lys Asn Gly 
            340                 345                 350         
Ala Tyr Glu Ile Lys Asp Pro Ala Val Leu Gln Gln Leu Gln Asp Leu 
        355                 360                 365             
Val Leu Thr Ala Lys Gly Gly Pro Gln Thr Lys Cys Val Gly Lys Ser 
    370                 375                 380                 
Ala Val Trp Leu Leu Ser Gln Ile Gly Ile Ser Val Asp Ala Ser Ile 
385                 390                 395                 400 
Lys Ile Ile Leu Met Glu Val Pro Arg Glu His Pro Phe Val Gln Glu 
                405                 410                 415     
Glu Leu Met Met Pro Ile Leu Pro Leu Val Arg Val Glu Thr Val Asp 
            420                 425                 430         
Asp Ala Ile Asp Leu Ala Ile Glu Val Glu His Asp Asn Arg His Thr 
        435                 440                 445             
Ala Ile Met His Ser Thr Asp Val Arg Lys Leu Thr Lys Met Ala Lys 
    450                 455                 460                 
Leu Ile Gln Thr Thr Ile Phe Val Lys Asn Gly Pro Ser Tyr Ala Gly 
465                 470                 475                 480 
His Gly Ala Gly Gly Glu Gly Tyr Ser Thr Phe Thr Ile Ala Gly Pro 
                485                 490                 495     
Thr Gly Glu Gly Leu Thr Ser Ala Lys Ser Phe Ala Arg Arg Arg Lys 
            500                 505                 510         
Cys Val Met Val Glu Ala Leu Asn Ile Arg 
        515                 520         

<210>  4
<211>  825
<212>  PRT
<213>  双歧杆菌(Bifidobacterium)

<400>  4
Met Thr Ser Pro Val Ile Gly Thr Pro Trp Lys Lys Leu Asn Ala Pro 
1               5                   10                  15      
Val Ser Glu Glu Ala Ile Glu Gly Val Asp Lys Tyr Trp Arg Ala Ala 
            20                  25                  30          
Asn Tyr Leu Ser Ile Gly Gln Ile Tyr Leu Arg Ser Asn Pro Leu Met 
        35                  40                  45              
Lys Glu Pro Phe Thr Arg Glu Asp Val Lys His Arg Leu Val Gly His 
    50                  55                  60                  
Trp Gly Thr Thr Pro Gly Leu Asn Phe Leu Ile Gly His Ile Asn Arg 
65                  70                  75                  80  
Leu Ile Ala Asp His Gln Gln Asn Thr Val Ile Ile Met Gly Pro Gly 
                85                  90                  95      
His Gly Gly Pro Ala Gly Thr Ala Gln Ser Tyr Leu Asp Gly Thr Tyr 
            100                 105                 110         
Thr Glu Tyr Phe Pro Asn Ile Thr Lys Asp Glu Ala Gly Leu Gln Lys 
        115                 120                 125             
Phe Phe Arg Gln Phe Ser Tyr Pro Gly Gly Ile Pro Ser His Tyr Ala 
    130                 135                 140                 
Pro Glu Thr Pro Gly Ser Ile His Glu Gly Gly Glu Leu Gly Tyr Ala 
145                 150                 155                 160 
Leu Ser His Ala Tyr Gly Ala Val Met Asn Asn Pro Ser Leu Phe Val 
                165                 170                 175     
Pro Ala Ile Val Gly Asp Gly Glu Ala Glu Thr Gly Pro Leu Ala Thr 
            180                 185                 190         
Gly Trp Gln Ser Asn Lys Leu Ile Asn Pro Arg Thr Asp Gly Ile Val 
        195                 200                 205             
Leu Pro Ile Leu His Leu Asn Gly Tyr Lys Ile Ala Asn Pro Thr Ile 
    210                 215                 220                 
Leu Ser Arg Ile Ser Asp Glu Glu Leu His Glu Phe Phe His Gly Met 
225                 230                 235                 240 
Gly Tyr Glu Pro Tyr Glu Phe Val Ala Gly Phe Asp Asn Glu Asp His 
                245                 250                 255     
Leu Ser Ile His Arg Arg Phe Ala Glu Leu Phe Glu Thr Val Phe Asp 
            260                 265                 270         
Glu Ile Cys Asp Ile Lys Ala Ala Ala Gln Thr Asp Asp Met Thr Arg 
        275                 280                 285             
Pro Phe Tyr Pro Met Ile Ile Phe Arg Thr Pro Lys Gly Trp Thr Cys 
    290                 295                 300                 
Pro Lys Phe Ile Asp Gly Lys Lys Thr Glu Gly Ser Trp Arg Ser His 
305                 310                 315                 320 
Gln Val Pro Leu Ala Ser Ala Arg Asp Thr Glu Ala His Phe Glu Val 
                325                 330                 335     
Leu Lys Asn Trp Leu Glu Ser Tyr Lys Pro Glu Glu Leu Phe Asp Glu 
            340                 345                 350         
Asn Gly Ala Val Lys Pro Glu Val Thr Ala Phe Met Pro Thr Gly Glu 
        355                 360                 365             
Leu Arg Ile Gly Glu Asn Pro Asn Ala Asn Gly Gly Arg Ile Arg Glu 
    370                 375                 380                 
Glu Leu Lys Leu Pro Lys Leu Glu Asp Tyr Glu Val Lys Glu Val Ala 
385                 390                 395                 400 
Glu Tyr Gly His Gly Trp Gly Gln Leu Glu Ala Thr Arg Arg Leu Gly 
                405                 410                 415     
Val Tyr Thr Arg Asp Ile Ile Lys Asn Asn Pro Asp Ser Phe Arg Ile 
            420                 425                 430         
Phe Gly Pro Asp Glu Thr Ala Ser Asn Arg Leu Gln Ala Ala Tyr Asp 
        435                 440                 445             
Val Thr Asn Lys Gln Trp Asp Ala Gly Tyr Leu Ser Ala Gln Val Asp 
    450                 455                 460                 
Glu His Met Ala Val Thr Gly Gln Val Thr Glu Gln Leu Ser Glu His 
465                 470                 475                 480 
Gln Met Glu Gly Phe Leu Glu Gly Tyr Leu Leu Thr Gly Arg His Gly 
                485                 490                 495     
Ile Trp Ser Ser Tyr Glu Ser Phe Val His Val Ile Asp Ser Met Leu 
            500                 505                 510         
Asn Gln His Ala Lys Trp Leu Glu Ala Thr Val Arg Glu Ile Pro Trp 
        515                 520                 525             
Arg Lys Pro Ile Ser Ser Met Asn Leu Leu Val Ser Ser His Val Trp 
    530                 535                 540                 
Arg Gln Asp His Asn Gly Phe Ser His Gln Asp Pro Gly Val Thr Ser 
545                 550                 555                 560 
Val Leu Leu Asn Lys Cys Phe Asn Asn Asp His Val Ile Gly Ile Tyr 
                565                 570                 575     
Phe Pro Val Asp Ser Asn Met Leu Leu Ala Val Ala Glu Lys Cys Tyr 
            580                 585                 590         
Lys Ser Thr Asn Lys Ile Asn Ala Ile Ile Ala Gly Lys Gln Pro Ala 
        595                 600                 605             
Ala Thr Trp Leu Thr Leu Asp Glu Ala Arg Ala Glu Leu Glu Lys Gly 
    610                 615                 620                 
Ala Ala Glu Trp Lys Trp Ala Ser Asn Val Lys Ser Asn Asp Glu Ala 
625                 630                 635                 640 
Gln Ile Val Leu Ala Ala Thr Gly Asp Val Pro Thr Gln Glu Ile Met 
                645                 650                 655     
Ala Ala Ala Asp Lys Leu Asp Ala Met Gly Ile Lys Phe Lys Val Val 
            660                 665                 670         
Asn Val Val Asp Leu Val Lys Leu Gln Ser Ala Lys Glu Asn Asn Glu 
        675                 680                 685             
Ala Leu Ser Asp Glu Glu Phe Ala Glu Leu Phe Thr Glu Asp Lys Pro 
    690                 695                 700                 
Val Leu Phe Ala Tyr His Ser Tyr Ala Arg Asp Val Arg Gly Leu Ile 
705                 710                 715                 720 
Tyr Asp Arg Pro Asn His Asp Asn Phe Asn Val His Gly Tyr Glu Glu 
                725                 730                 735     
Gln Gly Ser Thr Thr Thr Pro Tyr Asp Met Val Arg Val Asn Asn Ile 
            740                 745                 750         
Asp Arg Tyr Glu Leu Gln Ala Glu Ala Leu Arg Met Ile Asp Ala Asp 
        755                 760                 765             
Lys Tyr Ala Asp Lys Ile Asn Glu Leu Glu Ala Phe Arg Gln Glu Ala 
    770                 775                 780                 
Phe Gln Phe Ala Val Asp Asn Gly Tyr Asp His Pro Asp Tyr Thr Asp 
785                 790                 795                 800 
Trp Val Tyr Ser Gly Val Asn Thr Asn Lys Gln Gly Ala Ile Ser Ala 
                805                 810                 815     
Thr Ala Ala Thr Ala Gly Asp Asn Glu 
            820                 825 

<210>  5
<211>  660
<212>  PRT
<213>  沙门氏菌(Salmonella enterica)

<400>  5
Met Ala Gln Thr His Lys His Pro Val Pro Pro Asn Ile Ala Ala Asn 
1               5                   10                  15      
Ala Trp Ile Asn Pro Glu Gln Tyr Glu Ala Met Tyr Lys Gln Ser Ile 
            20                  25                  30          
Asn Asp Pro Asp Thr Phe Trp Arg Glu Gln Gly Lys Ile Leu Asp Trp 
        35                  40                  45              
Ile Lys Pro Tyr Thr Arg Val Lys Asn Thr Ser Phe Glu Pro Gly Asn 
    50                  55                  60                  
Val Ser Ile Arg Trp Tyr Glu Asp Gly Thr Leu Asn Leu Ala Tyr Asn 
65                  70                  75                  80  
Cys Leu Asp Arg His Leu Glu Glu Arg Gly Asp Gln Thr Ala Ile Ile 
                85                  90                  95      
Trp Glu Gly Asp Asp Pro Ser Glu Ser Arg His Ile Thr Tyr Arg Glu 
            100                 105                 110         
Leu His Arg Asp Val Cys Arg Phe Ala Asn Val Leu Lys Ala Leu Gly 
        115                 120                 125             
Ile Lys Lys Gly Asp Val Val Ala Ile Tyr Met Pro Met Val Pro Glu 
    130                 135                 140                 
Ala Ala Val Ala Met Leu Ala Cys Ala Arg Ile Gly Ala Ile His Ser 
145                 150                 155                 160 
Val Ile Phe Gly Gly Phe Ser Pro Glu Ala Val Ala Gly Arg Ile Ile 
                165                 170                 175     
Asp Ser Asn Ser Arg Leu Val Ile Thr Ala Asp Glu Gly Val Arg Ala 
            180                 185                 190         
Gly Arg Ser Ile Pro Leu Lys Lys Asn Val Asp Glu Ala Leu Lys Asn 
        195                 200                 205             
Pro Asn Val Thr Ser Val Glu His Val Ile Val Phe Lys Arg Thr Gly 
    210                 215                 220                 
Gly Asp Ile Asp Trp Gln Glu Gly Arg Asp Leu Trp Trp Arg Asp Leu 
225                 230                 235                 240 
Ile Glu Lys Ala Ser Pro Glu His Gln Pro Glu Pro Met Asn Ala Glu 
                245                 250                 255     
Asp Pro Leu Phe Ile Leu Tyr Thr Ser Gly Ser Thr Gly Lys Pro Lys 
            260                 265                 270         
Gly Val Leu His Thr Thr Gly Gly Tyr Leu Val Tyr Ala Ala Thr Thr 
        275                 280                 285             
Phe Lys Tyr Val Phe Asp Tyr His Pro Gly Asp Ile Tyr Trp Cys Thr 
    290                 295                 300                 
Ala Asp Val Gly Trp Ile Thr Gly His Ala Tyr Leu Leu Tyr Gly Pro 
305                 310                 315                 320 
Leu Ala Cys Gly Ala Thr Thr Leu Met Phe Glu Gly Val Pro Asn Trp 
                325                 330                 335     
Pro Thr Pro Ser Arg Met Ala Gln Val Val Asp Lys His Gln Val Asn 
            340                 345                 350         
Ile Leu Phe Thr Ala Pro Thr Ala Ile Arg Ala Leu Met Ala Glu Gly 
        355                 360                 365             
Asp Lys Ala Ile Glu Gly Thr Asp Arg Ser Ser Leu Arg Ile Leu Gly 
    370                 375                 380                 
Ser Thr Gly Glu Pro Ile Asn Pro Glu Ala Trp Glu Trp Tyr Trp Lys 
385                 390                 395                 400 
Lys Ile Gly Asn Glu Arg Cys Pro Val Val Asp Thr Trp Trp Gln Thr 
                405                 410                 415     
Glu Thr Gly Gly Cys Met Ile Thr Pro Leu Pro Gly Ala Ile Glu Leu 
            420                 425                 430         
Lys Pro Gly Ser Ala Thr Arg Pro Phe Phe Gly Val Gln Pro Ala Leu 
        435                 440                 445             
Val Asp Asn Glu Gly Asn Pro Gln Glu Gly Ala Thr Glu Gly Asn Leu 
    450                 455                 460                 
Val Ile Thr Asp Ser Trp Pro Gly Gln Ala Arg Thr Leu Tyr Gly Asp 
465                 470                 475                 480 
His Glu Arg Phe Glu Gln Thr Tyr Phe Ser Thr Phe Lys Gly Met Tyr 
                485                 490                 495     
Phe Ser Gly Asp Gly Ala Arg Arg Asp Glu Asp Gly Tyr Tyr Trp Ile 
            500                 505                 510         
Thr Gly Arg Val Asp Asp Val Leu Asn Val Ser Gly His Arg Leu Gly 
        515                 520                 525             
Thr Ala Glu Ile Glu Ser Ala Leu Val Ala His Pro Lys Ile Ala Glu 
    530                 535                 540                 
Ala Ala Val Val Gly Ile Pro His Asp Ile Lys Gly Gln Ala Ile Tyr 
545                 550                 555                 560 
Ala Tyr Val Thr Leu Asn His Gly Glu Glu Pro Ser Pro Glu Leu Tyr 
                565                 570                 575     
Lys Glu Val Arg Asn Trp Val Arg Lys Glu Ile Gly Pro Leu Ala Thr 
            580                 585                 590         
Pro Asp Val Leu His Trp Thr Asp Gly Leu Pro Lys Thr Arg Ser Gly 
        595                 600                 605             
Lys Ile Met Arg Arg Ile Leu Arg Lys Ile Ala Ala Gly Asp Thr Ser 
    610                 615                 620                 
Asn Leu Gly Asp Thr Ser Thr Leu Ala Asp Pro Ser Val Val Asp Lys 
625                 630                 635                 640 
Pro Ile Glu Glu Lys Gln Ala Ile Ala Met Pro Ser Leu Glu His His 
                645                 650                 655     
His His His His 
            660 

<210>  6
<211>  1200
<212>  DNA
<213>  大肠杆菌(Escherichia coli)

<400>  6
atgtcttcta aactggttct ggttctgaac tgcggttctt cttctctgaa attcgctatc        60
atcgacgctg ttaacggtga cgaatacctg tctggtctgg ctgaatgctt ccacctgccg       120
gaagctcgta tcaaatggaa aatggacggt tctaaacagg aagctgctct gggtgctggt       180
gctgctcact ctgaagctct gaacttcatc gttaacacca tcctggctca gaaaccggaa       240
ctgtctgctc agctgaccgc tatcggtcac cgtatcgttc acggtggtga aaaatacacc       300
tcttctgttg ttatcgacga atctgttatc cagggtatca aagactctgc ttctttcgct       360
ccgctgcaca acccggctca cctgatcggt atcgctgaag ctctgaaatc tttcccgcag       420
ctgaaagaca aaaacgttgc tgttttcgac accgctttcc accagaccat gccggaagaa       480
tcttacctgt acgctctgcc gtactctctg tacaaagaac acggtgttcg tcgttacggt       540
gctcacggta cctctcactt ctacgttacc caggaagctg ctaaaatgct gaacaaaccg       600
gttgaagaac tgaacatcat cacctgccac ctgggtaacg gtggttctgt ttctgctatc       660
cgtaacggta aatgcgttga cacctctatg ggtctgaccc cgctggaagg tctggttatg       720
ggtacccgtt ctggtgacat cgacccggct atcatcttcc acctgcacga caccctgggt       780
atgtctgttg accagatcaa caaaatgctg accaaagaat ctggtctgct gggtctgacc       840
gaagttacct ctgactgccg ttacgttgaa gacaactacg ctaccaaaga agacgctaaa       900
cgtgctatgg acgtttactg ccaccgtctg gctaaataca tcggttctta caccgctctg       960
atggacggtc gtctggacgc tgttgttttc accggtggta tcggtgaaaa cgctgctatg      1020
gttcgtgaac tgtctctggg taaactgggt gttctgggtt tcgaagttga ccacgaacgt      1080
aacctggctg ctcgtttcgg taaatctggt ttcatcaaca aagaaggtac ccgtccggct      1140
gttgttatcc cgaccaacga agaactggtt atcgctcagg acgcttctcg tctgaccgct      1200

<210>  7
<211>  2154
<212>  DNA
<213>  大肠杆菌(Escherichia coli)

<400>  7
atggctagcg tgtcccgtat tattatgctg atccctaccg gaaccagcgt cggtctgacc        60
agcgtcagcc ttggcgtgat ccgtgcaatg gaacgcaaag gcgttcgtct gagcgttttc       120
aaacctatcg ctcagccgcg taccggtggc gatgcgcccg atcagactac gactatcgtg       180
cgtgcgaact cttccaccac gacggccgct gaaccgctga aaatgagcta cgttgaaggt       240
ctgctttcca gcaatcagaa agatgtgctg atggaagaga tcgtcgcaaa ctaccacgct       300
aacaccaaag acgctgaagt cgttctggtt gaaggtctgg tcccgacacg taagcaccag       360
tttgcccagt ctctgaacta cgaaatcgct aaaacgctga atgcggaaat cgtcttcgtt       420
atgtctcagg gcactgacac cccggaacag ctgaaagagc gtatcgaact gacccgcaac       480
agcttcggcg gtgccaaaaa caccaacatc accggcgtta tcgttaacaa actgaacgca       540
ccggttgatg aacagggtcg tactcgcccg gatctgtccg agattttcga cgactcttcc       600
aaagctaaag taaacaatgt tgatccggcg aagctgcaag aatccagccc gctgccggtt       660
ctcggcgctg tgccgtggag ctttgacctg atcgcgactc gtgcgatcga tatggctcgc       720
cacctgaatg cgaccatcat caacgaaggc gacatcaata ctcgccgcgt taaatccgtc       780
actttctgcg cacgcagcat tccgcacatg ctggagcact tccgtgccgg ttctctgctg       840
gtgacttccg cagaccgtcc tgacgtgctg gtggccgctt gcctggcagc catgaacggc       900
gtagaaatcg gtgccctgct gctgactggc ggttacgaaa tggacgcgcg catttctaaa       960
ctgtgcgaac gtgctttcgc taccggcctg ccggtattta tggtgaacac caacacctgg      1020
cagacctctc tgagcctgca gagcttcaac ctggaagttc cggttgacga tcacgaacgt      1080
atcgagaaag ttcaggaata cgttgctaac tacatcaacg ctgactggat cgaatctctg      1140
actgccactt ctgagcgcag ccgtcgtctg tctccgcctg cgttccgtta tcagctgact      1200
gaacttgcgc gcaaagcggg caaacgtatc gtactgccgg aaggtgacga accgcgtacc      1260
gttaaagcag ccgctatctg tgctgaacgt ggtatcgcaa cttgcgtact gctgggtaat      1320
ccggcagaga tcaaccgtgt tgcagcgtct cagggtgtag aactgggtgc agggattgaa      1380
atcgttgatc cagaagtggt tcgcgaaagc tatgttggtc gtctggtcga actgcgtaag      1440
aacaaaggca tgaccgaaac cgttgcccgc gaacagctgg aagacaacgt ggtgctcggt      1500
acgctgatgc tggaacagga tgaagttgat ggtctggttt ccggtgctgt tcacactacc      1560
gcaaacacca tccgtccgcc gctgcagctg atcaaaactg caccgggcag ctccctggta      1620
tcttccgtgt tcttcatgct gctgccggaa caggtttacg tttacggtga ctgtgcgatc      1680
aacccggatc cgaccgctga acagctggca gaaatcgcga ttcagtccgc tgattccgct      1740
gcggccttcg gtatcgaacc gcgcgttgct atgctctcct actccaccgg tacttctggt      1800
gcaggtagcg acgtagaaaa agttcgcgaa gcaactcgtc tggcgcagga aaaacgtcct      1860
gacctgatga tcgacggtcc gctgcagtac gacgctgcgg taatggctga cgttgcgaaa      1920
tccaaagcgc cgaactctcc ggttgcaggt cgcgctaccg tgttcatctt cccggatctg      1980
aacaccggta acaccaccta caaagcggta cagcgttctg ccgacctgat ctccatcggg      2040
ccgatgctgc agggtatgcg caagccggtt aacgacctgt cccgtggcgc actggttgac      2100
gatatcgtct acaccatcgc gctgactgcg attcagtctg cacagcagca gtaa            2154

<210>  8
<211>  1569
<212>  DNA
<213>  假单胞菌(Pseudomonas aeruginosa)

<400>  8
atggcgcacc atcaccacca tcatgttggc accaacgatg cgaacatcgc cgatgttgtg        60
acgaaggttc tgggtgaata tggcgcgccg ggcgccgtta gtgttgccgc gctcaccgcc       120
aaaagtccgg atggtaagag caatagcagc gcggatgccg atgtggttgc gcgtatggtt       180
gccaaggcca ttcgcgatca cgcgggtacc gcccaaccaa gcggtaatgc cgccaccagt       240
agtgccgcgg ttagtgacgg cgtgtttgaa acgatggatg ccgccgttga agcggcggcg       300
ctggcccagc agcaatatct gctgtgcagc atgagtgatc gtgcccgctt cgtgcaaggc       360
attcgtgacg tgattctgaa tcaagatacg ctggagaaga tgagtcgtat ggccgttgaa       420
gagaccggca tgggcaacta cgagcacaag ctcatcaaga accgtctggc gggcgaaaaa       480
acgccgggca tcgaagatct gaccacggac gcgttcagcg gtgataacgg tctgacgctg       540
gttgaataca gcccattcgg cgttatcggc gccattaccc caacgaccaa tccgaccgaa       600
accatcgttt gcaacagcat cggcatgctc gccgccggta atagcgttgt gttcagtccg       660
catggtcgtg cccgtcaagt tagtctgctg ctggtgcgtc tgatcaatca gaaactcgcg       720
gcgctgggtg ccccggaaaa tctggtggtg acggtggaaa aaccgagccg cgaaaatacg       780
ctggccatga tggcgcaccc gaaagtgcgc atgctggttg ccacgggtgg tccagcgctg       840
gtgaaagccg ttctcagcac cggtaagaaa gccatcggtg ccggtgcggg taacccaccg       900
gttgtggtgg atgaaaccgc caacatcgag aaagcggcgt gcgacatcgt gaacggctgc       960
agctttgaca acaatatcac gtgcaccgcc gagaaggaga tcattgccgt ggcccagatt      1020
gccgactatc tgatcttcaa tctgaagaaa aatggcgcct acgaaatcaa agacccggcg      1080
gtgctgcagc agctgcaaga tctggtgctg acggccaaag gtggtccgca gaccaagtgt      1140
gtgggtaaaa gcgcggtttg gctgctgagc caaattggca tcagcgtgga cgccagcatc      1200
aagatcattc tgatggaggt tccgcgcgag catccgttcg tgcaagaaga actgatgatg      1260
ccgattctgc cactggtgcg tgtggaaacc gttgatgatg ccattgatct ggcgatcgaa      1320
gtggaacacg acaatcgcca tacggcgatc atgcacagca ccgacgtgcg taaactgacc      1380
aagatggcga agctgattca gacgaccatc ttcgtgaaaa acggtccaag ctacgccggt      1440
catggtgcgg gtggcgaagg ctatagtacg tttaccatcg ccggcccaac cggcgaaggt      1500
ctgacgagcg cgaaaagctt tgcgcgtcgt cgcaagtgtg tgatggttga ggccctcaat      1560
atccgctaa                                                              1569

<210>  9
<211>  2478
<212>  DNA
<213>  双歧杆菌(Bifidobacterium)

<400>  9
atgacctctc cggttatcgg taccccgtgg aaaaaactga acgcgccggt ttctgaagaa        60
gcgatcgaag gtgttgacaa atactggcgt gcggcgaact acctgtctat cggtcagatc       120
tacctgcgtt ctaacccgct gatgaaagaa ccgttcaccc gtgaagacgt taaacaccgt       180
ctggttggtc actggggtac caccccgggt ctgaacttcc tgatcggtca catcaaccgt       240
ctgatcgcgg accaccagca gaacaccgtt atcatcatgg gtccgggtca cggtggtccg       300
gcgggtaccg cgcagtctta cctggacggt acctacaccg aatacttccc gaacatcacc       360
aaagacgaag cgggtctgca gaaattcttc cgtcagttct cttacccggg tggtatcccg       420
tctcactacg cgccggaaac cccgggttct atccacgaag gtggtgaact gggttacgcg       480
ctgtctcacg cgtacggtgc ggttatgaac aacccgtctc tgttcgttcc ggcgatcgtt       540
ggtgacggtg aagcggaaac cggtccgctg gcgaccggtt ggcagtctaa caaactgatc       600
aacccgcgta ccgacggtat cgttctgccg atcctgcacc tgaacggtta caaaatcgcg       660
aacccgacca tcctgtctcg tatctctgac gaagaactgc acgagttctt ccacggtatg       720
ggttacgaac cgtacgagtt cgttgcgggt ttcgacaacg aagaccacct gtctatccac       780
cgtcgtttcg cggaactgtt cgaaaccgtt ttcgacgaaa tctgcgacat caaagcggcg       840
gcgcagaccg acgacatgac ccgtccgttc tacccgatga tcatcttccg taccccgaaa       900
ggttggacct gcccgaaatt catcgacggt aaaaaaaccg aaggttcttg gcgttctcac       960
caggttccgc tggcgtctgc gcgtgacacc gaagcgcact tcgaagttct gaaaaactgg      1020
ctggaatctt acaaaccgga agaactgttc gacgaaaacg gtgcggttaa accggaagtt      1080
accgcgttca tgccgaccgg tgaactgcgt atcggtgaaa acccgaacgc gaacggtggt      1140
cgtatccgtg aagaactgaa actgccgaaa ctggaagact acgaagttaa agaagttgcg      1200
gaatacggtc acggttgggg tcagctggaa gcgacccgtc gtctgggtgt ttacacccgt      1260
gacatcatca aaaacaaccc ggactctttc cgtatcttcg gtccggacga aaccgcgtct      1320
aaccgtctgc aggcggcgta cgacgttacc aacaaacagt gggacgcggg ttacctgtct      1380
gcgcaggttg acgaacacat ggcggttacc ggtcaggtta ccgaacagct gtctgaacac      1440
cagatggaag gtttcctgga aggttacctg ctgaccggtc gtcacggtat ctggtcttct      1500
tacgaatctt tcgttcacgt tatcgactct atgctgaacc agcacgcgaa atggctggaa      1560
gcgaccgttc gtgaaatccc gtggcgtaaa ccgatctctt ctatgaacct gctggtttct      1620
tctcacgttt ggcgtcagga ccacaacggt ttctctcacc aggacccggg tgttacctct      1680
gttctgctga acaaatgctt caacaacgac cacgttatcg gtatctactt cccggttgac      1740
tctaacatgc tgctggcggt tgcggaaaaa tgctacaaat ctaccaacaa aatcaacgcg      1800
atcatcgcgg gtaaacagcc ggcggcgacc tggctgaccc tggacgaagc gcgtgcggaa      1860
ctggaaaaag gtgcggcgga atggaaatgg gcgtctaacg ttaaatctaa cgacgaagcg      1920
cagatcgttc tggcggcgac cggtgacgtt ccgacccagg aaatcatggc ggcggcggac      1980
aaactggacg cgatgggtat caaattcaaa gttgttaacg ttgttgacct ggttaaactg      2040
cagtctgcga aagaaaacaa cgaagcgctg tctgacgaag agttcgcgga actgttcacc      2100
gaagacaaac cggttctgtt cgcgtaccac tcttacgcgc gtgacgttcg tggtctgatc      2160
tacgaccgtc cgaaccacga caacttcaac gttcacggtt acgaagaaca gggttctacc      2220
accaccccgt acgacatggt tcgtgttaac aacatcgacc gttacgaact gcaggcggaa      2280
gcgctgcgta tgatcgacgc ggacaaatac gcggacaaaa tcaacgaact ggaagcgttc      2340
cgtcaggaag cgttccagtt cgcggttgac aacggttacg accacccgga ctacaccgac      2400
tgggtttact ctggtgttaa caccaacaaa cagggtgcga tctctgcgac cgcggcgacc      2460
gcgggtgaca acgaatga                                                    2478

<210>  10
<211>  1983
<212>  DNA
<213>  沙门氏菌(Salmonella enterica)

<400>  10
atggctcaga cccacaaaca cccggttccg ccgaacatcg cggcgaacgc gtggatcaac        60
ccggaacagt acgaagcgat gtacaaacag tctatcaacg acccggacac cttctggcgt       120
gaacagggta aaatcctgga ctggatcaaa ccgtacaccc gtgttaaaaa cacctctttc       180
gaaccgggta acgtttctat ccgttggtac gaagacggta ccctgaacct ggcgtacaac       240
tgcctggacc gtcacctgga agaacgtggt gaccagaccg cgatcatctg ggaaggtgac       300
gacccgtctg aatctcgtca catcacctac cgtgaactgc accgtgacgt ttgccgtttc       360
gcgaacgttc tgaaagcgct gggtatcaaa aaaggtgacg ttgttgcgat ctacatgccg       420
atggttccgg aagcggcggt tgcgatgctg gcgtgcgcgc gtatcggtgc gatccactct       480
gttatcttcg gtggtttctc tccggaagcg gttgcgggtc gtatcatcga ctctaactct       540
cgtctggtta tcaccgcgga cgaaggtgtt cgtgcgggtc gttctatccc gctgaaaaag       600
aacgttgacg aagcgctgaa aaacccgaac gttacctctg ttgaacacgt tatcgttttc       660
aaacgtaccg gtggtgacat cgactggcag gaaggtcgtg acctgtggtg gcgtgacctg       720
atcgaaaaag cgtctccgga acaccagccg gaaccgatga acgcggaaga cccgctgttc       780
atcctgtaca cctctggttc taccggtaaa ccgaaaggtg ttctgcacac caccggtggt       840
tacctggttt acgcggcgac caccttcaaa tacgttttcg actaccaccc gggtgacatc       900
tactggtgca ccgcggacgt tggttggatt accggtcacg cgtatctgct gtacggtccg       960
ctggcgtgcg gtgcgaccac cctgatgttc gaaggtgttc cgaactggcc gaccccgtct      1020
cgtatggcgc aggttgttga caaacaccag gttaacatcc tgtttaccgc gccgaccgcg      1080
atccgtgcgc tgatggcgga aggtgacaaa gcgatcgaag gtaccgaccg ttcttctctg      1140
cgtatcctgg gttctaccgg tgaaccgatc aacccggaag cgtgggaatg gtactggaaa      1200
aaaatcggta acgaacgttg cccggttgtt gacacctggt ggcagaccga aaccggtggt      1260
tgcatgatca ccccgctgcc gggtgcgatc gaactgaaac cgggttctgc gacccgtccg      1320
ttcttcggtg ttcagccggc gctggttgac aacgaaggta acccgcagga aggtgcgacc      1380
gaaggtaacc tggttatcac cgactcttgg ccgggtcagg cgcgtaccct gtacggtgac      1440
cacgaacgtt tcgaacagac ctacttctct accttcaaag gtatgtactt ctctggtgac      1500
ggtgcgcgtc gtgacgaaga cggttactac tggatcaccg gtcgtgttga cgacgttctg      1560
aacgtttctg gtcaccgtct gggtaccgcg gaaatcgaat ctgcgctggt tgcgcacccg      1620
aaaatcgcgg aagcggcggt tgttggtatc ccgcacgaca tcaaaggtca ggcgatctac      1680
gcgtacgtta ccctgaacca cggtgaagaa ccgtctccgg aactgtacaa agaagttcgt      1740
aactgggttc gtaaagaaat cggtccgctg gcgaccccgg acgttctgca ctggaccgac      1800
ggtctgccga aaacccgttc tggtaaaatc atgcgtcgta tcctgcgtaa aatcgcggcg      1860
ggtgacacct ctaacctggg tgacacctct accctggcgg acccgtctgt tgttgacaaa      1920
ccgatcgaag aaaaacaggc gatcgcgatg ccgtctctcg agcaccacca ccaccaccac      1980
tga                                                                    1983

