                               SEQUENCE LISTING

<110> ALNYLAM PHARMACEUTICALS, INC.
 
<120> METHODS AND COMPOSITIONS FOR INHIBITION OF HAO1 (HYDROXYACID OXIDASE 1 (GLYCOLATE OXIDASE)) GENE EXPRESSION

<130> 121301-19920

<140>
<141>

<150> 63/182,608
<151> 2021-04-30

<150> 63/120,150
<151> 2020-12-01

<160> 15

<170> PatentIn version 3.5

<210> 1
<211> 1746
<212> DNA
<213> Homo sapiens

<400> 1
ctgggatagc aataacctgt gaaaatgctc ccccggctaa tttgtatcaa tgattatgaa       60

caacatgcta aatcagtact tccaaagtct atatatgact attacaggtc tggggcaaat      120

gatgaagaaa ctttggctga taatattgca gcattttcca gatggaagct gtatccaagg      180

atgctccgga atgttgctga aacagatctg tcgacttctg ttttaggaca gagggtcagc      240

atgccaatat gtgtgggggc tacggccatg cagcgcatgg ctcatgtgga cggcgagctt      300

gccactgtga gagcctgtca gtccctggga acgggcatga tgttgagttc ctgggccacc      360

tcctcaattg aagaagtggc ggaagctggt cctgaggcac ttcgttggct gcaactgtat      420

atctacaagg accgagaagt caccaagaag ctagtgcggc aggcagagaa gatgggctac      480

aaggccatat ttgtgacagt ggacacacct tacctgggca accgtctgga tgatgtgcgt      540

aacagattca aactgccgcc acaactcagg atgaaaaatt ttgaaaccag tactttatca      600

ttttctcctg aggaaaattt tggagacgac agtggacttg ctgcatatgt ggctaaagca      660

atagacccat ctatcagctg ggaagatatc aaatggctga gaagactgac atcattgcca      720

attgttgcaa agggcatttt gagaggtgat gatgccaggg aggctgttaa acatggcttg      780

aatgggatct tggtgtcgaa tcatggggct cgacaactcg atggggtgcc agccactatt      840

gatgttctgc cagaaattgt ggaggctgtg gaagggaagg tggaagtctt cctggacggg      900

ggtgtgcgga aaggcactga tgttctgaaa gctctggctc ttggcgccaa ggctgtgttt      960

gtggggagac caatcgtttg gggcttagct ttccaggggg agaaaggtgt tcaagatgtc     1020

ctcgagatac taaaggaaga attccggttg gccatggctc tgagtgggtg ccagaatgtg     1080

aaagtcatcg acaagacatt ggtgaggaaa aatcctttgg ccgtttccaa gatctgacag     1140

tgcacaatat tttcccatct gtattatttt ttttcagcat gtattacttg acaaagagac     1200

actgtgcaga gggtgaccac agtctgtaat tccccacttc aatacaaagg gtgtcgttct     1260

tttccaacaa aatagcaatc ccttttattt cattgctttt gacttttcaa tgggtgtcct     1320

aggaaccttt tagaaagaaa tggactttca tcctggaaat atattaactg ttaaaaagaa     1380

aacattgaaa atgtgtttag acaacgtcat cccctggcag gctaaagtgc tgtatccttt     1440

agtaaaattg gaggtagcaa acactaaggt gaaaagataa tgatctcatt gtttattaac     1500

ctgtattctg tttacatgtc tttaaaacag tggttcttaa attgtaagct caggttcaaa     1560

gtgttggtaa tgcctgattc acaactttga gaaggtagca ctggagagaa ttggaatggg     1620

tggcggtaat tggtgatact tctttgaatg tagatttcca atcacatctt tagtgtctga     1680

atatatccaa atgttttagg atgtatgtta cttcttagag agaaataaag catttttggg     1740

aagaat                                                                1746


<210> 2
<211> 1746
<212> DNA
<213> Homo sapiens

<400> 2
attcttccca aaaatgcttt atttctctct aagaagtaac atacatccta aaacatttgg       60

atatattcag acactaaaga tgtgattgga aatctacatt caaagaagta tcaccaatta      120

ccgccaccca ttccaattct ctccagtgct accttctcaa agttgtgaat caggcattac      180

caacactttg aacctgagct tacaatttaa gaaccactgt tttaaagaca tgtaaacaga      240

atacaggtta ataaacaatg agatcattat cttttcacct tagtgtttgc tacctccaat      300

tttactaaag gatacagcac tttagcctgc caggggatga cgttgtctaa acacattttc      360

aatgttttct ttttaacagt taatatattt ccaggatgaa agtccatttc tttctaaaag      420

gttcctagga cacccattga aaagtcaaaa gcaatgaaat aaaagggatt gctattttgt      480

tggaaaagaa cgacaccctt tgtattgaag tggggaatta cagactgtgg tcaccctctg      540

cacagtgtct ctttgtcaag taatacatgc tgaaaaaaaa taatacagat gggaaaatat      600

tgtgcactgt cagatcttgg aaacggccaa aggatttttc ctcaccaatg tcttgtcgat      660

gactttcaca ttctggcacc cactcagagc catggccaac cggaattctt cctttagtat      720

ctcgaggaca tcttgaacac ctttctcccc ctggaaagct aagccccaaa cgattggtct      780

ccccacaaac acagccttgg cgccaagagc cagagctttc agaacatcag tgcctttccg      840

cacacccccg tccaggaaga cttccacctt cccttccaca gcctccacaa tttctggcag      900

aacatcaata gtggctggca ccccatcgag ttgtcgagcc ccatgattcg acaccaagat      960

cccattcaag ccatgtttaa cagcctccct ggcatcatca cctctcaaaa tgccctttgc     1020

aacaattggc aatgatgtca gtcttctcag ccatttgata tcttcccagc tgatagatgg     1080

gtctattgct ttagccacat atgcagcaag tccactgtcg tctccaaaat tttcctcagg     1140

agaaaatgat aaagtactgg tttcaaaatt tttcatcctg agttgtggcg gcagtttgaa     1200

tctgttacgc acatcatcca gacggttgcc caggtaaggt gtgtccactg tcacaaatat     1260

ggccttgtag cccatcttct ctgcctgccg cactagcttc ttggtgactt ctcggtcctt     1320

gtagatatac agttgcagcc aacgaagtgc ctcaggacca gcttccgcca cttcttcaat     1380

tgaggaggtg gcccaggaac tcaacatcat gcccgttccc agggactgac aggctctcac     1440

agtggcaagc tcgccgtcca catgagccat gcgctgcatg gccgtagccc ccacacatat     1500

tggcatgctg accctctgtc ctaaaacaga agtcgacaga tctgtttcag caacattccg     1560

gagcatcctt ggatacagct tccatctgga aaatgctgca atattatcag ccaaagtttc     1620

ttcatcattt gccccagacc tgtaatagtc atatatagac tttggaagta ctgatttagc     1680

atgttgttca taatcattga tacaaattag ccgggggagc attttcacag gttattgcta     1740

tcccag                                                                1746



<210> 3
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      RFGF peptide

<400> 3
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 4
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      RFGF analogue peptide

<400> 4
Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210> 5
<211> 13
<212> PRT
<213> Human immunodeficiency virus

<400> 5
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210> 6
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 6
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 7
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 7
gcatcctggg ctacactga                                                    19


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 8
tgggtgtcgc tgttgaagtc                                                   20


<210> 9
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 9
ccaggtggtc tcctcc                                                       16


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<400> 10
cuuacgcuga guacuucgat t                                                 21


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
ucgaaguacu cagcguaagt t                                                 21


<210> 12
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
gacuuucauc cuggaaauau a                                                 21


<210> 13
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
uauauuucca ggaugaaagu cca                                               23


<210> 14
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
gacuuucauc cuggaaauau a                                                 21


<210> 15
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
uauauuucca ggaugaaagu cca                                               23






