                         SEQUENCE LISTING

<110>  CELLULAR BIOMEDICINE GROUP HK LIMITED
       Cellular Biomedicine Group Inc.
 
<120>  BCMA-Targeted Chimeric Antigen Receptors

<130>  11299/008884-WO1

<150>  17/476,661
<151>  2021-09-16

<150>  63/212,289
<151>  2021-06-18

<150>  63/153,666
<151>  2021-02-25

<150>  63/120,692
<151>  2020-12-02

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA-20 light chain variable region

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  2
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA-20 heavy chain variable region

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  3
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA-CA8 light chain variable region

<400>  3

Asp Ile Gln Leu Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Thr Thr Thr Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Glu Leu Val Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu His Gly Gly Gly Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Gly Tyr Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Ser Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  4
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA-CA8 heavy chain variable region

<400>  4

Glu Val Gln Leu Gln Gln Ser Gly Ala Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Thr Tyr Arg Gly His Ser Asp Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Ala Ile Tyr Asn Gly Tyr Asp Val Leu Asp Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  5
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA-MO6 light chain variable region

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  6
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA-MO6 heavy chain variable region

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Thr Tyr Arg Gly His Ser Asp Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ile Tyr Asp Gly Tyr Asp Val Leu Asp Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  7
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA-1 light chain variable region

<400>  7

Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu Gly 
1               5                   10                  15      


Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu 
            20                  25                  30          


Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  8
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA-1 heavy chain variable region

<400>  8

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe 
    50                  55                  60                  


Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 Signal peptide

<400>  9

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  10
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  10

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  11

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  12
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  12

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp 
    50                  55  


<210>  13
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  13

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  14
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB Costimulatory sequence

<400>  14

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  15
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta

<400>  15

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  16
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17

Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr 
1               5                   10                  15  


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19

Tyr Thr Ser Asn Leu Gln Ser 
1               5           


<210>  20
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21

Met Gly Gln Thr Ile Ser Ser Tyr Thr 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22

Phe Gly Gln Gly Thr Lys Leu Glu Ile 
1               5                   


<210>  23
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24

Asn Phe Asp Met Ala 
1               5   


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val Ser 
1               5                   10                  


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26

Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
            20                  25                  30          


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28

His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
1               5                   10          


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  30
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30

Asp Ile Gln Leu Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys 
            20              


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31

Ser Ala Ser Thr Thr Thr Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32

Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Glu Leu Val Ile Tyr 
1               5                   10                  15  


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33

Tyr Thr Ser Asn Leu His Gly 
1               5           


<210>  34
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34

Gly Gly Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Gly Tyr Leu Glu Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35

Gln Gln Tyr Arg Lys Leu Pro Trp Thr 
1               5                   


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36

Phe Gly Gly Gly Ser Lys Leu Glu Ile Lys Arg 
1               5                   10      


<210>  37
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37

Glu Val Gln Leu Gln Gln Ser Gly Ala Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38

Asn Tyr Trp Met His 
1               5   


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39

Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40

Ala Thr Tyr Arg Gly His Ser Asp Thr Tyr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41

Lys Ala Lys Leu Thr Ala Val Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42

Gly Ala Ile Tyr Asn Gly Tyr Asp Val Leu Asp Asn 
1               5                   10          


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  44
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45

Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47

Tyr Thr Ser Asn Leu His Ser 
1               5           


<210>  48
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49

Gln Gln Tyr Arg Lys Leu Pro Trp Thr 
1               5                   


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
1               5                   10      


<210>  51
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser 
            20                  25                  30  


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52

Asn Tyr Trp Met His 
1               5   


<210>  53
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  53

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  54

Ala Thr Tyr Arg Gly His Ser Asp Thr Tyr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  55

Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  56

Gly Ala Ile Tyr Asp Gly Tyr Asp Val Leu Asp Asn 
1               5                   10          


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  57

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  58
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  58
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgaccca gtccccctcc tccctgtccg cctccgtggg cgaccgggtg      120

accatcacct gccgggcctc ccagggcatc tccaactacc tgaactggta ccagcagaag      180

cccggcaagg cccccaagcc cctgatctac tacacctcca acctgcagtc cggcgtgccc      240

tcccggttct ccggctccgg ctccggcacc gactacaccc tgaccatctc ctccctgcag      300

cccgaggact tcgccaccta ctactgcatg ggccagacca tctcctccta caccttcggc      360

cagggcacca agctggagat caagggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgcagct ggtggagtcc ggcggcggcc tggtgcagcc cggcggctcc      480

ctgcggctgt cctgcgccgc ctccggcttc accttctcca acttcgacat ggcctgggtg      540

cggcaggccc ccggcaaggg cctggtgtgg gtgtcctcca tcaccaccgg cgccgaccac      600

gccatctacg ccgactccgt gaagggccgg ttcaccatct cccgggacaa cgccaagaac      660

accctgtacc tgcagatgaa ctccctgcgg gccgaggaca ccgccgtgta ctactgcgtg      720

cggcacggct actacgacgg ctaccacctg ttcgactact ggggccaggg caccctggtg      780

accgtgtcct ccttcgtgcc ggtcttcctg ccagcgaagc ccaccacgac gccagcgccg      840

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg      900

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc      960

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1020

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1080

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1140

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1200

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1260

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1320

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1380

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1440

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1494


<210>  59
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  59

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln 
            100                 105                 110         


Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe Asp 
                165                 170                 175     


Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val Ser 
            180                 185                 190         


Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
225                 230                 235                 240 


Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Phe Val Pro Val Phe Leu Pro Ala 
            260                 265                 270         


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
        275                 280                 285             


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
    290                 295                 300                 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
305                 310                 315                 320 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
                325                 330                 335     


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            340                 345                 350         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        355                 360                 365             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    370                 375                 380                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
385                 390                 395                 400 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


Arg 
    


<210>  60
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  60
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggatatcc agctgaccca gaccacaagc agcctgagcg cctccctggg cgacagggtg      120

accattagct gcagcgccag ccaggacatc agcaactacc tgaactggta ccagcagaag      180

cccgacggca ccgtggagct cgtgatctac tacacctcca acctgcacag cggcgtgccc      240

agcaggttct ctggcagcgg cagcggcacc gactacagcc tgaccatcgg ctatctggag      300

cccgaggacg tcgccaccta ctactgccag cagtacagga agctgccctg gaccttcggc      360

ggaggctcta agctggagat taagcgtggt ggcggtggct cgggcggtgg tgggtcgggt      420

ggcggcggat ctgaggtgca gctgcagcag agcggcgccg tgctggccag gcccggagct      480

agcgtgaaga tgagctgcaa gggcagcggc tacaccttca ccaactactg gatgcactgg      540

gtgaaacaga ggcccggcca gggactggag tggatcggcg ccacctacag gggccacagc      600

gacacctact acaaccagaa gttcaagggc aaggccaagc tgaccgccgt gacctcaacc      660

agcaccgcct acatggaact gagcagcctg accaacgagg acagcgccgt ctattactgc      720

accaggggcg ccatctacaa cggctacgac gtgctggaca attggggcca gggaacacta      780

gtgaccgtgt ccagcttcgt gccggtcttc ctgccagcga agcccaccac gacgccagcg      840

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag      900

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat      960

atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     1020

accctttact gcaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1080

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1140

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag     1200

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1260

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1320

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1380

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1440

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa        1497


<210>  61
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  61

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Glu Leu Val Ile Tyr Tyr Thr Ser Asn Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Gly Tyr Leu Glu Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Arg Lys Leu Pro Trp Thr Phe Gly Gly Gly Ser Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Gln Gln Ser Gly Ala Val Leu Ala Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Met Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
                165                 170                 175     


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Ala Thr Tyr Arg Gly His Ser Asp Thr Tyr Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Thr Ser Thr Ala Tyr 
    210                 215                 220                 


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Thr Arg Gly Ala Ile Tyr Asn Gly Tyr Asp Val Leu Asp Asn Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Phe Val Pro Val Phe Leu Pro 
            260                 265                 270         


Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    290                 295                 300                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                325                 330                 335     


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg 
        


<210>  62
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  62
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgaccca gagccctagc tcactgagcg ccagcgtggg cgacagggtg      120

accattacct gctccgccag ccaggacatc agcaactacc tgaactggta ccagcagaag      180

cccggcaagg cccccaagct gctgatctac tacacctcca acctgcactc cggcgtgccc      240

agcaggttca gcggaagcgg cagcggcacc gatttcaccc tgaccatctc cagcctgcag      300

cccgaggact tcgccaccta ctactgccag cagtacagga agctcccctg gactttcggc      360

cagggcacca aactggagat caagcgtggt ggcggtggct cgggcggtgg tgggtcgggt      420

ggcggcggat ctcaggtgca gctggtccag agcggcgccg aagtgaagaa gcccggcagc      480

tccgtgaaag tgagctgcaa ggccagcggc ggcaccttca gcaactactg gatgcactgg      540

gtgaggcagg cccccggaca gggcctggag tggatgggcg ccacctacag gggccacagc      600

gacacctact acaaccagaa gttcaagggc cgggtgacca tcaccgccga caagagcacc      660

agcaccgcct acatggaact gagcagcctc aggagcgagg acaccgctgt gtattactgc      720

gccaggggcg ccatctacga cggctacgac gtgctggaca actggggcca gggcacacta      780

gtgaccgtgt ccagcttcgt gccggtcttc ctgccagcga agcccaccac gacgccagcg      840

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag      900

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat      960

atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     1020

accctttact gcaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1080

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1140

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag     1200

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1260

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1320

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1380

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1440

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa        1497


<210>  63
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  63

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Asn Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Arg Lys Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
145                 150                 155                 160 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
                165                 170                 175     


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
            180                 185                 190         


Gly Ala Thr Tyr Arg Gly His Ser Asp Thr Tyr Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
    210                 215                 220                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Arg Gly Ala Ile Tyr Asp Gly Tyr Asp Val Leu Asp Asn Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Phe Val Pro Val Phe Leu Pro 
            260                 265                 270         


Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    290                 295                 300                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                325                 330                 335     


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg 
        


