                         SEQUENCE LISTING

<110>  Locanabio, Inc.
 
<120>  RNA-TARGETING COMPOSITIONS AND METHODS FOR TREATING MYOTONIC 
       DYSTROPHY TYPE 1

<130>  LOCN-007/001WO 330675-2074


<150>  US 63/278,746
<151>  2021-11-12

<150>  US 63/130,092
<151>  2020-12-23

<150>  US 63/119,977
<151>  2020-12-01


<160>  651   

<170>  PatentIn version 3.5

<210>  1
<211>  954
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Eubacterium siraeum nCas1

<400>  1

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Pro Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Arg Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asp Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Lys Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Glu Ser Asp Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Phe Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  2
<211>  954
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Eubacterium siraeum nCas1 HEPN-/-

<400>  2

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Pro Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Arg Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asp Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Ala His Trp Cys Val Ala Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Lys Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Glu Ser Asp Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Phe Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Ala Asn Thr Val Cys Ala Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  3
<211>  919
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Uncultured Ruminococcus sp. nCas1

<400>  3

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Gln Leu Gly Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Asp 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Gly Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  4
<211>  919
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Uncultured Ruminococcus sp. nCas1 HEPN-/-

<400>  4

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Gln Leu Gly Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Ala 
        275                 280                 285             


Gln Cys Val Phe Ala Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Asp 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Gly Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Ala Asn Cys Ile Ala Ala Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  5
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig2791000549

<400>  5

Met Lys Gln Asn Asp Arg Glu Asn Asn Asn Lys Ile Lys Lys Ser Ala 
1               5                   10                  15      


Ala Lys Ala Val Gly Val Lys Ser Leu Ala Arg Leu Ser Asp Gly Ser 
            20                  25                  30          


Thr Val Val Ser Ser Phe Gly Lys Gly Ala Ala Ala Glu Leu Glu Ser 
        35                  40                  45              


Leu Ile Thr Gly Gly Glu Ile Arg Lys Leu Ser Asp Lys Ala Ile Leu 
    50                  55                  60                  


Glu Ile Thr Asp Asp Thr Gln Asn Lys Asn Ala Tyr Asn Val Lys Ser 
65                  70                  75                  80  


Ser Arg Ile Pro Asn Leu Thr Ala Arg Thr Asp Lys Leu Ser Asp Lys 
                85                  90                  95      


Ser Gly Met Asp Asp Leu Gly Phe Lys Arg Glu Leu Glu Leu Glu Val 
            100                 105                 110         


Phe Gly Gln Cys Phe Asp Asp Ser Ile His Ile Gln Ile Ala His Ala 
        115                 120                 125             


Val Phe Asp Ile Gln Lys Ser Leu Ala Ala Val Ile Pro Asn Val Leu 
    130                 135                 140                 


Tyr Thr Leu Asn Asn Leu Asp Arg Ser Tyr Ser Thr Asp Asn Thr Ser 
145                 150                 155                 160 


Asp Lys Lys Asp Ile Ile Gly Asn Thr Leu Asn Tyr Gln His Ser Tyr 
                165                 170                 175     


Glu Ser Phe Asn Val Glu Lys Arg Gly Glu Phe Thr Glu Tyr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Asp Arg Phe Ser Tyr Phe Pro Asp Ile Leu Cys Val Leu 
        195                 200                 205             


Glu Lys Val Asn Gly Lys Asp Arg Tyr Gln Pro Lys Ser Glu Lys Asp 
    210                 215                 220                 


Ala Phe Asn Val Leu Ser Ser Val Asn Met Leu Arg Asn Ser Leu Phe 
225                 230                 235                 240 


His Phe Ala Pro Lys Ser Asn Asp Gly Lys Ala Arg Ile Ala Val Phe 
                245                 250                 255     


Lys Asn Gln Phe Asp Ser Asp Phe Ser His Ile Thr Ser Thr Val Asn 
            260                 265                 270         


Lys Ile Tyr Ser Ala Lys Ile Ala Gly Val Asn Glu Asn Phe Leu Asn 
        275                 280                 285             


Asn Glu Gly Asn Asn Leu Tyr Ile Ile Leu Lys Ala Thr Asn Trp Asp 
    290                 295                 300                 


Ile Lys Lys Ile Val Pro Gln Leu Tyr Arg Phe Ser Val Leu Lys Ser 
305                 310                 315                 320 


Asp Lys Asn Met Gly Phe Asn Met Arg Lys Leu Arg Glu Phe Ala Val 
                325                 330                 335     


Glu Ser Lys Asn Ile Asp Leu Ser Arg Leu Asn Asp Lys Phe Leu Thr 
            340                 345                 350         


Asn Asn Arg Lys Lys Leu Tyr Lys Val Ile Asp Phe Ile Ile Tyr Tyr 
        355                 360                 365             


His Leu Asn Lys Val Leu Lys Asp Ser Phe Val Asp Asp Phe Val Ala 
    370                 375                 380                 


Ala Leu Arg Ala Ser Gln Ser Glu Glu Glu Lys Glu Lys Leu Tyr Ala 
385                 390                 395                 400 


Gln Tyr Ser Glu Arg Leu Phe Ala 
                405             


<210>  6
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig855000317

<400>  6

Thr Asp Asn Pro Leu His Gly Ala Gly Gly Ile Ala Arg Asp His Ser 
1               5                   10                  15      


Asp Leu Ile His Ala Arg Lys Ala Leu Glu Met Arg Tyr Tyr Gly Gln 
            20                  25                  30          


Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp 
        35                  40                  45              


Ile Glu Lys Ile Leu Ser Val His Ile Asn Asn Ile Val Tyr Thr Leu 
    50                  55                  60                  


Asn Asn Leu Leu Arg Pro Leu Thr Asp Asn Asn Phe Asp Phe Ile Gly 
65                  70                  75                  80  


Glu Leu Ser Thr Tyr Arg Asp Tyr Glu Lys Phe Leu Glu Val Ser Glu 
                85                  90                  95      


Ile Glu Tyr Ile Ile Asp Glu Asn Gly Glu Glu Lys Gln Asn Lys Glu 
            100                 105                 110         


Tyr Thr Lys Arg Lys Leu Phe Phe Arg Leu Cys Tyr Met Pro Gln Leu 
        115                 120                 125             


Arg Tyr Phe Asn Ile Ile Val Glu Gly Pro His Glu Pro Val Val Gln 
    130                 135                 140                 


Val Glu Asn Pro Glu Leu Leu Lys Lys Ile Glu Ala Ser Arg Ile Ser 
145                 150                 155                 160 


Asp Arg Ala Lys Thr Val Thr Phe Asn Glu Lys Glu Phe Tyr Asn Val 
                165                 170                 175     


Leu Ile Ala Leu Gly Thr Leu Arg Gln Met Glu Ala His Gly Asn Pro 
            180                 185                 190         


Leu Ile Asn Ile Tyr Gln Phe Asp Lys Lys Gln Asn Val Tyr Ser Thr 
        195                 200                 205             


Leu Thr Lys Lys Tyr Lys Glu Arg Val Ile Thr Leu Asp Asn Gly Phe 
    210                 215                 220                 


Leu Ser Arg Ala Lys Lys Asn Leu Ile Ile Leu Phe Arg Ala Tyr Gly 
225                 230                 235                 240 


Ile Glu Asp Ala Glu Glu Lys Lys Gln Tyr Ile Arg Asn Tyr Tyr Asp 
                245                 250                 255     


Phe Thr Val Arg Lys Asn Tyr Lys Asn Gln Gly Phe Ser Ile Lys Thr 
            260                 265                 270         


Leu Arg Glu His Ile Thr Thr Asp Ile Glu Glu Ala Ile Gln Leu Arg 
        275                 280                 285             


Ser Thr Ala Phe Asp Ser Val 
    290                 295 


<210>  7
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig3389000027

<400>  7

Pro Glu Lys Ala Ala Phe Thr Val His Asn Asp Cys Glu Ala Phe Phe 
1               5                   10                  15      


Glu Ile Asp Gly Arg Val Gln Arg Ala Val Ala Asp Asn Pro Leu His 
            20                  25                  30          


Lys Tyr Glu Lys Asp Asp His Gly Gln Asp Arg Ile Ser Arg Glu Lys 
        35                  40                  45              


Leu Glu Met Arg Tyr Tyr Gly Arg Thr Phe Glu Asp Asn Ile His Ile 
    50                  55                  60                  


Gln Val Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Met Ser Ile His 
65                  70                  75                  80  


Ile Asn Asn Ile Ile Phe Thr Ile Asn Asn Leu Leu Arg Arg Glu Glu 
                85                  90                  95      


Glu Asp Phe Ser Asp Leu Ile Gly Tyr Ile Thr Leu Cys Glu Lys Tyr 
            100                 105                 110         


Glu Asp Leu Ser Lys Lys Gly Arg Glu Glu Ile Arg Asp Ser Phe Asp 
        115                 120                 125             


Arg Leu Cys Lys Ala Pro Gln Leu Ala Tyr Tyr Asn Phe Gln Ile Glu 
    130                 135                 140                 


Lys Lys Gly Lys Lys Asp Pro Asn Ala Ile Ile Leu Thr Glu Lys 
145                 150                 155                 


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig8061000170

<400>  8

Glu Val Thr Gly Arg Gly Gln Gly Ala Thr Ala Asp Asn Pro Leu Tyr 
1               5                   10                  15      


Lys Tyr Ser Gln Lys Lys Ala Trp Asp Arg Gln Asp Arg Ile Ser Lys 
            20                  25                  30          


Asp Lys Leu Glu Leu Arg Tyr Tyr Gly Gln Thr Phe Glu Asp Asn Ile 
        35                  40                  45              


His Ile Gln Thr Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ser 
    50                  55                  60                  


Ile His Ile Asn Asn Ile Val Phe Thr Ile Asn Asn Leu Leu Arg Asn 
65                  70                  75                  80  


Asp Asn Asp Glu Gln Asp Asp Ile Val Gly Tyr Ile Ser Leu Cys Lys 
                85                  90                  95      


Lys Tyr Ala Asp Leu Ser Lys Glu Lys Asn Ala Glu 
            100                 105             


<210>  9
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig1509000299

<400>  9

Met Lys Ser Thr Phe Val Leu Gly Glu Asn Asn Leu Leu Met Thr Ser 
1               5                   10                  15      


Phe Gly Lys Gly Asn Lys Ala Val Val Glu Lys Gln Ile Arg Asp Gln 
            20                  25                  30          


Gln Ile Thr Asp Leu Ser Asp Pro Ser Ala Phe Thr Val Lys Gln Asp 
        35                  40                  45              


Lys Asp Leu His Phe Asn Ile Asp Gly Arg Val Arg Gly Ala Ser Thr 
    50                  55                  60                  


Asp Asn Pro Phe His His Asn Pro Glu Lys Thr Ala Gln Pro Pro Val 
65                  70                  75                  80  


Arg Asp Asp Leu Ile His Ala Arg Ser Phe Leu Glu Lys Arg Tyr Tyr 
                85                  90                  95      


Gly Glu Asn Phe Thr Asp Asn Ile His Ile Gln Cys Ile Tyr Ser Ile 
            100                 105                 110         


Leu Asp Val Glu Lys Ile Leu Val Ser His Ile Asn Asn Ile Val Tyr 
        115                 120                 125             


Met Leu Asn Asn Phe Leu Arg Glu Glu Gly Glu Thr Leu Thr Asp Leu 
    130                 135                 140                 


Ile Gly Tyr Leu Ser Ile Phe Lys Ser Tyr Glu Gly Leu Met Asn Ser 
145                 150                 155                 160 


Thr Arg Asn Asp Ala Ala Glu Met Arg Arg His Phe Phe Ser Leu Cys 
                165                 170                 175     


Gln Ala Lys Gln Leu Gly Tyr Leu Asn Leu Glu Val Leu Lys Pro Gln 
            180                 185                 190         


Pro Asp Lys Pro Lys Gln Gly Lys Lys Lys Pro Ala Asp Pro Asn Thr 
        195                 200                 205             


Ile Lys Leu Thr Glu Glu Glu Phe Phe Asn Val Leu Leu Ala Leu Ser 
    210                 215                 220                 


Asn Met Arg Gln Met Leu Val His Gly Asn Ala Lys Gln 
225                 230                 235         


<210>  10
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig9549000591

<400>  10

Lys Ala Lys Leu Glu Lys Arg Tyr Phe Gly Gln Thr Phe Glu Asp Asn 
1               5                   10                  15      


Ile His Ile Gln Val Ile Tyr Asn Met Leu Asp Ile Glu Lys Ile Leu 
            20                  25                  30          


Thr Ile His Val Asn Asn Ile Val Phe Thr Ile Asn Asn Phe Leu Arg 
        35                  40                  45              


Glu Glu Gly Glu Asp Leu Thr Asp Ile Val Gly Tyr Ile Thr Lys Tyr 
    50                  55                  60                  


Lys Ser Leu Ala Lys Phe Lys Glu Asn Lys Asn Ala Arg Glu Tyr Tyr 
65                  70                  75                  80  


Glu Leu Phe Cys Lys Leu Cys Asp Ala Lys Gln Leu Gly Tyr Leu Asn 
                85                  90                  95      


Leu Glu Tyr Asn Ser Val Arg Ser Lys Leu Tyr Lys Leu Phe Asp Phe 
            100                 105                 110         


Ile Leu Val His His Tyr Lys Asn Asp Ser Ser Pro Glu Ser Thr Ala 
        115                 120                 125             


Leu Lys Asn Leu Leu Arg Thr Cys Leu Thr Asp Glu Glu Lys Glu Lys 
    130                 135                 140                 


Val Tyr Val Gln Thr Ala Lys Glu Leu Thr Ala Leu Tyr Ser Tyr His 
145                 150                 155                 160 


Phe Lys Glu Ala Ser Val Ser Val Asn Ala Arg Asn Ile Lys Glu Tyr 
                165                 170                 175     


Gln Glu Lys Ala Gln Val Tyr His Ile Ser Ile Ala Asp Lys Ile Ser 
            180                 185                 190         


Ser Thr Gly Ile Gly Leu Phe Ser Gln Leu Ile Tyr Met Leu Thr Leu 
        195                 200                 205             


Leu Leu Asp Gly Lys Glu 
    210                 


<210>  11
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig71000500

<400>  11

Met Lys Lys Gln Lys Ser Lys Lys Thr Val Ser Lys Thr Ser Gly Leu 
1               5                   10                  15      


Lys Glu Ala Leu Ser Val Gln Gly Thr Val Ile Met Thr Ser Phe Gly 
            20                  25                  30          


Lys Gly Asn Met Ala Asn Leu Ser Tyr Lys Ile Pro Ser Ser Gln Lys 
        35                  40                  45              


Pro Gln Asn Leu Asn Ser Ser Ala Gly Leu Lys Asn Val Glu Val Ser 
    50                  55                  60                  


Gly Lys Lys Ile Lys Phe Gln Gly Arg His Pro Lys Ile Ala Thr Thr 
65                  70                  75                  80  


Asp Asn Pro Leu Phe Lys Pro Gln Pro Gly Met Asp Leu Leu Cys Leu 
                85                  90                  95      


Lys Asp Lys Leu Glu Met His Tyr Phe Gly Lys Thr Phe Asp Asp Asn 
            100                 105                 110         


Ile His Ile Gln Leu Ile Tyr Gln Ile Leu Asp Ile Glu Lys Ile Leu 
        115                 120                 125             


Ala Val His Val Asn Asn Ile Val Phe Thr Leu Asp Asn Val Leu His 
    130                 135                 140                 


Pro Gln Lys Glu Glu Leu Thr Glu Asp Phe Ile Gly Ala Gly Gly Trp 
145                 150                 155                 160 


Arg Ile Asn Leu Asp Tyr Gln Thr Leu Arg Gly Gln Thr Asn Lys Tyr 
                165                 170                 175     


Asp Arg Phe Lys Asn Tyr Ile Lys Arg Lys Glu Leu Leu Tyr Phe Gly 
            180                 185                 190         


Glu Ala Phe Tyr His Glu Asn Glu Arg Arg Tyr Glu Glu Asp Ile Phe 
        195                 200                 205             


Ala Ile Leu Thr Leu Leu Ser Ala Leu Arg Gln Phe Cys Phe His Ser 
    210                 215                 220                 


Asp Leu Ser Ser Asp Glu Ser Asp His Val Asn Ser Phe Trp Leu Tyr 
225                 230                 235                 240 


Gln Leu Glu Asp Gln Leu Ser Asp Glu Phe Lys Glu Thr Leu Ser Ile 
                245                 250                 255     


Leu Trp Glu Glu Val Thr Glu Arg Ile Asp Ser Glu Phe Leu Lys Thr 
            260                 265                 270         


Asn Thr Val Asn Leu His Ile Leu Cys His Val Phe Pro Lys Glu Ser 
        275                 280                 285             


Lys Glu Thr Ile Val Arg Ala Tyr Tyr Glu Phe Leu Ile Lys Lys Ser 
    290                 295                 300                 


Phe Lys Asn Met Gly Phe Ser Ile Lys Lys Leu Arg Glu Ile Met Leu 
305                 310                 315                 320 


Glu Gln Ser Asp Leu Lys Ser Phe Lys Glu Asp Lys Tyr Asn Ser Val 
                325                 330                 335     


Arg Ala Lys Leu Tyr Lys Leu Phe Asp Phe Ile Ile Thr Tyr Tyr Tyr 
            340                 345                 350         


Asp His His Ala Phe Glu Lys Glu Ala Leu Val Ser Ser Leu Arg Ser 
        355                 360                 365             


Ser Leu Thr Glu Glu Asn Lys Glu Glu Ile Tyr Ile Lys Thr Ala Arg 
    370                 375                 380                 


Thr Leu Ala Ser Ala Leu Gly Ala Asp Phe Lys Lys Ala Ala Ala Asp 
385                 390                 395                 400 


Val Asn Ala Lys Asn Ile Arg Asp Tyr Gln Lys Lys Ala Asn Asp Tyr 
                405                 410                 415     


Arg Ile Ser Phe Glu Asp 
            420         


<210>  12
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  exemplary Cas13d sequence from human gut metagenome

<400>  12

Ile Lys Ile Gly Asn Thr Gly Ile Gly Tyr Phe Ser Glu Leu Ile Tyr 
1               5                   10                  15      


Met Leu Thr Leu Leu Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr 
            20                  25                  30          


Thr Leu Ile Asn Lys Phe Asp Asn Ile Ile Ser Phe Ile Asp Ile Leu 
        35                  40                  45              


Lys 
    


<210>  13
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig3915000357

<400>  13

Met Lys Asp Lys Leu Glu Gln Trp Tyr Phe Asp Lys Thr Phe Asp Asp 
1               5                   10                  15      


Asn Ile His Ile Gln Leu Ile Tyr Gln Ile Gln Asp Ile Glu Lys Ile 
            20                  25                  30          


Leu Ala Ser His Val Asn Asn Ile Val Phe Ala Leu Asp Asn Ile Leu 
        35                  40                  45              


His Ala Thr Glu Ser Glu Thr Gly Asp Phe Leu Gly Met Gly Tyr Met 
    50                  55                  60                  


Arg Ala Thr Asn Thr Phe Glu Glu Tyr Arg Asp Ser Ala Ile Ser Asn 
65                  70                  75                  80  


Val Lys Lys Ser Tyr Glu Thr Phe Glu Thr Tyr Ile Lys Lys Lys Glu 
                85                  90                  95      


Leu Leu Tyr Phe Gly Glu Ala Phe Tyr His Gly Asn Thr Cys Arg Lys 
            100                 105                 110         


Pro Glu Asp Ile Tyr His Ile Leu Ala Met Val Ser Ser Leu Arg Gln 
        115                 120                 125             


Phe Cys Phe His Ser Thr Phe Asp Asp Lys Ser Lys Ser Ile Lys Gly 
    130                 135                 140                 


Ser Trp Leu Tyr 
145             


<210>  14
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig4719000173

<400>  14

Lys Asn Val Ile Thr Ser Arg Ser Phe Tyr Tyr Leu Val Arg Tyr Ala 
1               5                   10                  15      


Lys Pro Thr Ala Val Arg Lys Leu Met Ser Asn Pro Lys Ile Val Arg 
            20                  25                  30          


Tyr Val Leu Lys Arg Leu Pro Glu Asn Gln Val Ala Ser Tyr Tyr Ser 
        35                  40                  45              


Ala Ile Trp Thr Gln Ser Glu Ser Asn Ser Asn Glu Thr Val Lys Leu 
    50                  55                  60                  


Ile Glu Met Ile Asp Arg Leu Thr Thr Glu Ile Ala Gly Phe Ser Phe 
65                  70                  75                  80  


Ala Val Leu Lys Asp Lys Lys Asp Ser Ile Val Ser Ala Ser Arg Glu 
                85                  90                  95      


Ser Arg Ala Val Asn Leu Glu Val Glu Arg Leu Lys Lys Leu Thr Thr 
            100                 105                 110         


Leu Tyr Met Ser Ile Ala Tyr Ile Ala Val Lys Ser Leu Val Lys Val 
        115                 120                 125             


Asn Ala Arg Tyr Phe Ile Ala Tyr Ser 
    130                 135         


<210>  15
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig6929000468

<400>  15

Met Lys Thr Ile Lys Lys Ser Ser Lys Ala Tyr Gly Leu Lys Ser Thr 
1               5                   10                  15      


Phe Ala Tyr Asn Asp Asp Val Tyr Met Thr Ser Phe Gly Lys Gly Asn 
            20                  25                  30          


Asp Phe Val Met Glu Lys Leu Ile Tyr Pro Asn Asp Asn Val Glu Asp 
        35                  40                  45              


Leu Ser Asp Asn Pro Lys Phe Asp Val Glu Val Glu Asn Lys Asp Ile 
    50                  55                  60                  


Thr Leu Lys Tyr Lys Lys Ser Glu Ile Asn Val Asn Asn Pro Ala Lys 
65                  70                  75                  80  


Ser Gly Ile Lys Gln Asp Tyr Leu Met Leu Lys Asp Lys Leu Glu 
                85                  90                  95  


<210>  16
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig7367000486

<400>  16

Asn Arg Leu Lys Thr Lys Ala Asp Leu Glu Arg Leu Phe Ser Asn Arg 
1               5                   10                  15      


Arg Ile Gly Tyr Phe Gly Gln Ala Phe Tyr Glu Ser Asp Lys Gln Gln 
            20                  25                  30          


Arg Asn Glu Met Glu Ile Tyr Asp Asn Leu Ala Leu Ile Gly Ser Leu 
        35                  40                  45              


Arg Gln Trp Ala Val His Gly Asn Lys Thr Asn Asp Pro Ala Trp Leu 
    50                  55                  60                  


Tyr Lys Leu Glu Ser Leu Pro Asp Glu Phe Lys Ser Val Leu Asp Lys 
65                  70                  75                  80  


Val Tyr Ala Glu Thr Val Arg Lys Val Asn Tyr Lys Phe Ile Lys Thr 
                85                  90                  95      


Asn Ala Val Asn Leu Gln Ile Leu Gln Glu Leu Tyr Pro Lys Glu Ser 
            100                 105                 110         


Phe Ala 
        


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig7930000403

<400>  17

Tyr Ala Lys Ile Ile Ile Gly Glu Ile Thr Ser Lys Tyr Asn Lys Phe 
1               5                   10                  15      


Asp Asp Ile Ile Asn Leu Val Tyr Arg Glu Ile Arg Asn Arg Asn Asn 
            20                  25                  30          


Thr Ile Asn Phe Lys Asn Glu Ile Lys Asn Ile Ser Thr Ile Thr Asn 
        35                  40                  45              


Tyr Ser Tyr Phe Thr Lys Phe Ile Tyr Phe Ile Thr Lys Phe Leu Asp 
    50                  55                  60                  


Gly Lys Glu Ile Asn Glu Leu Leu Thr Ser Leu Ile Asn Lys Phe Asp 
65                  70                  75                  80  


Asn Ile Gln Ala Phe Asn Asp Ile Leu Leu Glu Lys Leu Gln Asp Lys 
                85                  90                  95      


Asn Glu Ser Lys Phe Ala Ile Phe Asn Gly Lys 
            100                 105         


<210>  18
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig993000527

<400>  18

Asn Ile Asp Ser Leu Thr Ala Val Tyr Lys Gly Val Asn Asn Gln Asn 
1               5                   10                  15      


Arg Val Glu Phe Gly Asp Lys Tyr Asp Met Phe Asn Lys Ala Gly Glu 
            20                  25                  30          


Ile Cys Glu Ser Leu Arg Ser Ile Asn Ser Phe Ala Arg Met Glu Ser 
        35                  40                  45              


Pro Ala Pro Ala Ala Lys Arg Thr Met Phe Val Asp Ala Ile Arg Met 
    50                  55                  60                  


Phe Gly Phe Ala Asp Val Ser Asp Asn Asp Ala Glu Lys Phe Tyr Lys 
65                  70                  75                  80  


Glu Asn Ile Glu Pro Phe Ile Tyr Asp Arg Asn Gly Asp Ile Glu Asp 
                85                  90                  95      


Glu Trp Lys Lys Gly Lys Leu Val His Lys Lys Asp Glu Lys Lys Lys 
            100                 105                 110         


Gly Val Tyr Asn Phe Ile Ala Thr Asn Val Ile Glu Ser Asn Arg Phe 
        115                 120                 125             


Gln Tyr Leu Val Arg Tyr Ala Asn Thr Glu Lys Ile Ala Ala Leu Ala 
    130                 135                 140                 


Arg Asn Glu Thr Ile Val Arg Phe Val Ile Lys Lys Leu Pro Ala Ala 
145                 150                 155                 160 


Gln Ile Val Arg Tyr Tyr Ile Ala Cys Asn Arg Ile Arg Glu Asn Ile 
                165                 170                 175     


Asn Ser Asn Val Leu Thr Ser Asp Asp Met Ala Glu Ser Leu Val Lys 
            180                 185                 190         


Leu Val Thr Gly Met Asp Phe Gly Lys Ile Lys Gly Val Arg Asn Asp 
        195                 200                 205             


Asp Arg Ser Gly Asp Lys Glu Met Lys Lys Ala Ile Val Thr Leu Tyr 
    210                 215                 220                 


Leu Thr Ile Leu Tyr His Leu Thr Lys Asn Leu Val Tyr Val Asn Ser 
225                 230                 235                 240 


Arg Tyr Phe Met Ala Phe His Cys Leu Glu Arg Asp Met Asn Leu Phe 
                245                 250                 255     


Gly Glu Gly Gln Lys Gln Ala Leu Arg Asn Thr Gly Asp Tyr Pro Ala 
            260                 265                 270         


Asp Asn Ala Asp Leu Arg Arg Ser Asp Ile 
        275                 280         


<210>  19
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig6552000639

<400>  19

Ala Val Asp Leu Asn Pro Asp Asp Pro Ala Phe Asn Val Asn Glu Val 
1               5                   10                  15      


Thr Glu Glu Arg Phe Ile Leu Asp His Gly Arg Ile Lys Gly Cys Ile 
            20                  25                  30          


Ala Thr Ala Asp Asn Pro Leu His Ala Ser Ser Ala Pro Gln Asp Met 
        35                  40                  45              


Leu Leu Leu Lys Ser Val Leu Glu Glu Arg Phe Phe Gly Met Ser Phe 
    50                  55                  60                  


Pro Glu Asp Asn Val His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile 
65                  70                  75                  80  


Glu Lys Ile Leu Thr Val Tyr Ser Thr Asn Ala Val Tyr Ala Ile Asn 
                85                  90                  95      


Asn Leu Phe Arg Ala Asp Asp Gln Glu Asp Asp Glu Phe Ile Gly Asp 
            100                 105                 110         


Leu Ser Val Asp Thr Ser 
        115             


<210>  20
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig11932000246

<400>  20

Arg Ile Val Asn Ser Phe Ala His Met Lys Lys Glu Ser Met Ser Ala 
1               5                   10                  15      


Lys Lys Ile Met Phe Asp Glu Ala Leu Ile Val Leu Gly Ile Asp Asp 
            20                  25                  30          


Ala Glu Lys Glu Arg Glu Leu Asp Gln Met Leu Asp Lys Asp Ala Arg 
        35                  40                  45              


Lys Gln Asn Pro Gln Arg Ala Gly Leu Arg Asn Phe Ile Ala Asn Asn 
    50                  55                  60                  


Val Ile Glu Ser Asp Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Val 
65                  70                  75                  80  


Lys Arg Ile Lys Gly Ile Ala 
                85          


<210>  21
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig12963000286

<400>  21

Glu Lys Glu Thr Glu Leu Asn Leu Met Leu Asp Lys Asp Ala Arg Lys 
1               5                   10                  15      


Gln Asn Arg Gln Lys Ala Gly Leu Arg Asn Phe Ile Ala Asn Asn Val 
            20                  25                  30          


Ile Glu Ser Glu Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Val Lys 
        35                  40                  45              


Arg Ile Lys Gly Leu Ser Thr Asn Ser Gln Val Met Gly Phe Val Leu 
    50                  55                  60                  


Lys Asp Ile Ala Asp Ala Gln Ile Val Arg Tyr Tyr Arg Ser Ile Tyr 
65                  70                  75                  80  


Gly Asp Asp Asn Cys 
                85  


<210>  22
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig2952000470

<400>  22

Ile Arg Leu Pro Asn Gly Thr Ile Met Asp Glu Cys Asp Val Ser Lys 
1               5                   10                  15      


Ala Thr Thr Val Lys Asn Arg Tyr Leu His Asn Lys Lys Trp Tyr Ser 
            20                  25                  30          


Leu Ala Phe Thr Asn Tyr Lys Asn Ser Asp Ser Asp Val Ile Val Asn 
        35                  40                  45              


Phe Arg Asn Ser Val Ala His Leu Asn Ala Ile Arg Asn Ile Asp Glu 
    50                  55                  60                  


Tyr Ile Asp Gly Ile Gly Glu Ile Asn Ser His Thr Gly Tyr Phe Glu 
65                  70                  75                  80  


Ile Tyr His Tyr Ile Ile Gln Lys Arg Met Gln Ala Val Thr Thr Asp 
                85                  90                  95      


Lys Ser Lys Leu Gln Pro Lys Thr Glu Glu Tyr Phe Glu Asn Leu Ser 
            100                 105                 110         


Lys Tyr His Thr Tyr Cys Lys Asp Phe Val Lys Ala Tyr Cys Val Pro 
        115                 120                 125             


Met Ala Tyr Asn Leu Pro Arg Tyr Lys Asn Leu Thr Ile Asp Gly Gln 
    130                 135                 140                 


Phe Asp Arg Asn Ile His Thr Glu Thr Lys Glu 
145                 150                 155 


<210>  23
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig451000394

<400>  23

Leu Gln Glu Leu Tyr Pro Lys Glu Ser Phe Ala Ser Ile Val Lys Glu 
1               5                   10                  15      


Tyr Tyr Gly Phe Leu Val Thr Lys Lys Tyr Lys Asn Ile Gly Phe Ser 
            20                  25                  30          


Ile Lys His Leu Arg Glu Ile Leu Leu Asp Ser Thr Asp Tyr Arg Asp 
        35                  40                  45              


Lys Glu Tyr Asp Ser Val Arg His Lys Leu Tyr Gln Leu Leu Asp Phe 
    50                  55                  60                  


Cys Ile Tyr His Gly Tyr Leu Tyr Glu Asp Ala Glu Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Val Asn Gln Leu Arg Ala Ser Leu Ser Glu Leu Asp Lys Glu Lys 
                85                  90                  95      


Ile Tyr Asn Ile Glu Ala Ala Arg Leu Ala Asp Lys Leu Gly Ser Ser 
            100                 105                 110         


Leu Phe Ser Tyr Leu Arg Arg Ser Val Val Gly Lys Asn Ile Gln Gln 
        115                 120                 125             


Leu Lys Lys Asn Ala Glu Asn Leu Glu Lys Val Lys Leu Glu Asp Ile 
    130                 135                 140                 


Gln Ile Ser Ser Gly Lys Thr Val Ser Tyr Phe Thr Lys Leu Met Tyr 
145                 150                 155                 160 


Leu Leu Thr Leu Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr 
                165                 170                 175     


Thr Leu Ile Asn Lys Phe Asp Asn Ile Arg Val Phe Asn Lys Thr Leu 
            180                 185                 190         


Thr Gln Leu Asn Gln Ser Thr Glu Phe Val Glu Asp Tyr Ser Phe Phe 
        195                 200                 205             


Gly Ser Ser Gly Thr Val Phe Glu Glu Leu Thr Val Leu Asn Ser Phe 
    210                 215                 220                 


Ala Arg Met Ser Arg Ile Asp Pro Ser Ala Arg Lys Asp Met Tyr Arg 
225                 230                 235                 240 


Asp Ala Ile Glu Ile Leu Gly Ile Ser Met Glu Met Ser His Glu Lys 
                245                 250                 255     


Phe Glu Glu Met Leu Asp Arg Ile Leu Cys Tyr Asp Glu Glu Gly Asn 
            260                 265                 270         


Pro Ile Ile Asn Pro Asp Gly Thr Lys Lys Ser Gly Met Arg Asn Phe 
        275                 280                 285             


Ile Ala Thr Asn Ile Ile Ser Ser Asn Arg Phe Lys Tyr Leu Val Arg 
    290                 295                 300                 


Tyr Gly Asn Ala Thr Lys Ile Arg Ala Leu Ala Asn Cys Glu Asn Ala 
305                 310                 315                 320 


Val Lys Phe Val Leu Ser Thr Ile Pro Asp Glu Gln Ile Val Arg Tyr 
                325                 330                 335     


Phe Asp Ser Cys Arg Glu Pro Thr Asp His Ile Glu Asn Asn Ile Glu 
            340                 345                 350         


Arg Lys Arg Glu Tyr Leu Ala Ser Ile Ile Lys Glu Met Ser Phe Glu 
        355                 360                 365             


Arg Phe Arg Asp Ala Glu Lys Leu Gln Arg Tyr His Val Asp Arg Pro 
    370                 375                 380                 


Thr Asn Gly Ser Ser Val Glu Gly Glu Gln Lys Gln Arg Tyr Gln Ala 
385                 390                 395                 400 


Val Ile Arg Leu Tyr Leu 
                405     


<210>  24
<211>  954
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Eubacterium_siraeum_DSM_15702

<400>  24

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Pro Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Arg Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asp Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Lys Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Glu Ser Asp Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Phe Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  25
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  gut_metagenome_P19E0k2120140920,_c369000003

<400>  25

Asp Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn Lys Thr 
1               5                   10                  15      


Glu Asn Ile Ala Ser Phe Asn Glu Val Leu Lys Gln Leu Gly Tyr Glu 
            20                  25                  30          


Leu Asp Tyr Ser Glu Glu Tyr Ser Val Phe Ala Ala Ser Asp Glu Met 
        35                  40                  45              


Ala Ser Gln Leu Arg Ala Leu Asn Ser Phe Ala Arg Met Glu Lys Pro 
    50                  55                  60                  


Asp Ala Ser Ala Lys Arg Ile Met Phe Val Glu Ala Ala Arg Met Leu 
65                  70                  75                  80  


Gly Asp Asp Ser Ser Tyr Glu Glu Leu Lys Ala Tyr Phe Asp Asp Ile 
                85                  90                  95      


Leu Ala Lys Lys Ser Lys Lys Glu Phe Asp Ala Ala Thr Asp Asn Glu 
            100                 105                 110         


Ala Ile Arg Ala Thr Asp Lys Lys Lys Lys Gly Phe Arg Asn Phe Ile 
        115                 120                 125             


Ile Asn Asn Val Ile Glu Ser Asp Arg Phe Lys Tyr Leu Ile Arg Tyr 
    130                 135                 140                 


Cys Asn Val Glu Ser Val Gln Ala Phe Ser Lys Asn Arg Lys Leu Val 
145                 150                 155                 160 


Lys Phe Val Leu Lys Asp Ile Pro Glu Ser Gln Ile Leu 
                165                 170             


<210>  26
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig7593000362

<400>  26

Arg Met Ser Glu Glu Ala Pro Ser Ala Lys Lys Val Met Tyr Val Glu 
1               5                   10                  15      


Ala Ala Lys Val Leu Gly Tyr Ser Glu Pro Glu Glu Asp Leu Glu Thr 
            20                  25                  30          


Tyr Ile Glu Gly Ile Leu Asp Lys Lys Lys Asn Val Asp Ala Ser Gly 
        35                  40                  45              


Lys Lys Asn Met Asn Phe Arg Asn Phe Ile Ala Asn Asn Val Ile Glu 
    50                  55                  60                  


Ser Arg Arg Phe Lys Tyr Leu Val Arg Tyr Cys Asn Pro Glu Lys Ile 
65                  70                  75                  80  


Arg Ala Met Ala Glu Asn Arg Lys Val Val Ser Phe Val Leu Lys Gly 
                85                  90                  95      


Ile Pro Asp Ala Gln Ile Arg Ala Tyr Tyr Asn Ser Cys Asn Gly 
            100                 105                 110     


<210>  27
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig12619000055

<400>  27

Lys Leu Asn Ala Gly Phe Ala Asp Lys Ala Lys Thr Asp Met Gln Val 
1               5                   10                  15      


Leu Leu Asp Val Leu Lys Ile Lys Gly Gln Glu Lys Glu Ile Glu Ile 
            20                  25                  30          


Ala Gln Asn Tyr Tyr Glu Phe Ile Val Lys Lys Gly Tyr Lys Asn Glu 
        35                  40                  45              


Gly Phe Ser Ile Lys Lys Leu Arg Gln Lys Leu Thr Ser Leu Ser Glu 
    50                  55                  60                  


Ser Glu Lys Glu Pro Leu Asn Ser Met Arg Tyr Asp Ser Val Arg Pro 
65                  70                  75                  80  


Lys Leu Asn His Leu Leu 
                85      


<210>  28
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig1405000151

<400>  28

Lys Glu Leu Phe Gln Lys Leu Cys Lys Ala Pro Gln Leu Ala Tyr Phe 
1               5                   10                  15      


Asn Leu Gln Ile Glu Thr Glu Gly Lys Arg Lys Ala Asp Pro Asn Ala 
            20                  25                  30          


Ile Lys Leu Thr Gln Glu Asp Phe Phe Ser Ile Leu Tyr Thr Leu Gly 
        35                  40                  45              


Tyr Met Arg Gln Met Leu Met His Gly Ala Pro Asn Gln Asn Ile Tyr 
    50                  55                  60                  


Lys Met Asp Pro Leu Lys Asp Lys Thr Phe Lys Asn Cys Leu Asp Cys 
65                  70                  75                  80  


Leu Asn Arg Leu Tyr Asn Glu Arg Val Met Ala Leu Asn Asn Asn Phe 
                85                  90                  95      


Leu Asp Leu Ala Lys Lys Asn Leu Ser Ile Leu Phe Asp Val Phe Ala 
            100                 105                 110         


Val Lys Thr Gln Glu Glu Lys Ala Glu Tyr Val Arg Asp Tyr Tyr Asp 
        115                 120                 125             


Phe Val Val Arg Lys Gln Phe Lys Asn Gln Gly Phe Ser Ile Lys Cys 
    130                 135                 140                 


Leu Arg Glu His Met Thr Asp Asp Ile Glu Glu Ala Gly Thr Leu Arg 
145                 150                 155                 160 


Asp Gln Lys Tyr Asp Ser Val Arg Gly Lys Leu Tyr Pro Phe Ile Asn 
                165                 170                 175     


Phe Ala Ile Phe Arg Tyr Tyr Asn Ser His Ser Ser Glu Ala Glu Ala 
            180                 185                 190         


Leu Val Glu Arg Leu Arg Ala Ser Met Asn Glu Glu Glu Lys Asp Lys 
        195                 200                 205             


Val Tyr Arg His Glu Ala Val Ile Leu Trp Ser Lys Ile Arg Asn Leu 
    210                 215                 220                 


Val Leu Lys His Ile Leu Pro Glu Met Glu Gly Ser 
225                 230                 235     


<210>  29
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Chicken_gut_metagenome_c298474

<400>  29

Ser Asp His Asp Lys Lys Ala Leu Val Gln Glu Tyr Tyr Glu Phe Val 
1               5                   10                  15      


Val Leu Lys Asn Tyr Lys Asn Leu Gly Phe Ser Ile Arg Arg Leu Arg 
            20                  25                  30          


Asp Thr Ile Ile Ala Arg Glu Thr Gly Ala Asp Ile Leu Ser Asp Thr 
        35                  40                  45              


Glu Tyr Asp Thr Val Arg Ser Lys Leu Tyr Arg Ala Met Asp Phe Lys 
    50                  55                  60                  


Ile Tyr Leu Tyr Tyr Gln Glu His Pro Glu Lys Ala Lys Thr Leu Ile 
65                  70                  75                  80  


Glu Cys Leu Arg Ala Ser Thr Glu Glu Ala Glu Lys Glu Trp Ile Tyr 
                85                  90                  95      


Arg Arg Glu Ala Ser Ala Val 
            100             


<210>  30
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig1516000227

<400>  30

Asn Lys Phe Asp Gly Glu Ser Cys Lys Ser Phe Pro Leu Leu Met Tyr 
1               5                   10                  15      


Leu Leu Cys Lys Phe Leu Asp Ala Lys Glu Val Asn Glu Leu Leu Thr 
            20                  25                  30          


Ser Ile Ile Asn Lys Leu Glu Asn Ile Glu Ser Leu Ile Asp Ala Leu 
        35                  40                  45              


Val Thr Leu Asn Lys Trp Asp Gly Phe Ser Ser Asn Tyr Ser Leu Phe 
    50                  55                  60                  


Asp Lys Gln Asn Ile Arg Ser Leu Ile Asn Asp Phe Arg Leu Val Lys 
65                  70                  75                  80  


Asn Leu Ser Ser Ser Lys Arg Lys Leu Lys Lys Ala Lys Gln Tyr Glu 
                85                  90                  95      


Tyr Gln Lys Asn Lys Gln Leu Tyr Ala Asp Ala Ile Asn Leu Phe Lys 
            100                 105                 110         


Lys Asp Asn Phe Val His Leu Asn Asp Glu Glu Gly Thr Gly Leu Asp 
        115                 120                 125             


Leu Tyr Leu Ser Thr Leu Leu Thr Lys Lys Ser Gly Asn Arg Gly Asp 
    130                 135                 140                 


Lys Val Lys Asn Phe Ile Glu Ser Ala Ile Ile Lys Asn Arg Arg Phe 
145                 150                 155                 160 


Val Tyr Leu Ile Arg Tyr Ala Asp Pro Glu Lys Cys Tyr Lys Leu Val 
                165                 170                 175     


His Asn Glu Lys Met Leu Arg Phe Val Leu Gly Glu Tyr Asn Glu Glu 
            180                 185                 190         


Met Met Pro Leu Ser Gln Leu Gln Lys Tyr Tyr Asn Ala Val Thr Glu 
        195                 200                 205             


Asn Asn Asp Ser Asn Cys Glu Asn Arg Asn Lys Met Ile Asp Thr Leu 
    210                 215                 220                 


Val 
225 


<210>  31
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig1838000319

<400>  31

Leu Glu Tyr Gln Ile Thr Pro Glu Asn Asp Val Val Lys Leu Pro Val 
1               5                   10                  15      


Ser Asn Ser Ser Ser Ile Thr Val Asn Ser Ala Asn Asp Asn Ile Phe 
            20                  25                  30          


Glu Val Thr Thr Ser Arg Ser Asp Leu Lys Asp Leu Glu Ala Lys Pro 
        35                  40                  45              


Ser Asn Pro Thr Lys Lys Ser Lys Ser Ser Glu Lys Ser Pro Arg Gln 
    50                  55                  60                  


Asp Met Leu Gly Leu Lys Ser Ala Leu Glu Lys Glu Tyr Phe Gly Lys 
65                  70                  75                  80  


Glu Phe Asn Asp Asn Ile His Ile Gln Ile Ile His Cys Ile Gln Asp 
                85                  90                  95      


Ile Glu Lys Ile Leu Ala Val Tyr Ser Thr Asn Ala Asn Tyr Ala Leu 
            100                 105                 110         


Val Asn Leu Leu Gly His Asn Phe Lys Asp Glu Ser Gly Lys Arg Glu 
        115                 120                 125             


Asp Phe Leu Gly Ser Asp Ala Phe Lys Ile Glu Met Ser Tyr Glu Ser 
    130                 135                 140                 


Phe Ser Ala Pro Ala Asn Glu Thr Lys Leu Ser Ser Glu Lys Glu Arg 
145                 150                 155                 160 


Thr Arg Glu Asn Glu Glu Lys Arg Leu Lys Tyr Leu Glu Asp Phe Asn 
                165                 170                 175     


Asn Met Thr Asp Pro Asp Asn Tyr Asp Lys Arg Leu Gly Tyr Phe Gly 
            180                 185                 190         


Glu Ala Phe Phe Lys Pro Ser Lys Asn Arg Gly Lys Asp Thr Val Ala 
        195                 200                 205             


Asp Thr 
    210 


<210>  32
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig13123000268

<400>  32

Ser Pro Lys Asp Ala Gly Leu Ala Tyr Arg Pro Ala Gly Val Arg Pro 
1               5                   10                  15      


Asp Gln Ile Gly Ala Lys Ala Ala Leu Glu Lys Arg Tyr Phe Gly Lys 
            20                  25                  30          


Glu Thr Pro Gly Asp Asn Ile His Val Gln Ile Ala Tyr Gln Ile Gln 
        35                  40                  45              


Asp Ile Glu Lys Leu Leu Ala Val Tyr Ile Ser Asn Ile Ile Tyr Ala 
    50                  55                  60                  


Val Asn Asn Val Thr Gly Val Ser Ala Met Lys Asp Ser Lys Gly Arg 
65                  70                  75                  80  


Pro Val Asp Leu 
                


<210>  33
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig5294000434

<400>  33

Asp Lys Val Val His Val Asn Val Ala Gln Gly Ile Arg Asp Phe Ile 
1               5                   10                  15      


Glu Asp Phe Lys Ser Asn Ser Asp Phe Ser Met Asn Ser Tyr Phe Glu 
            20                  25                  30          


Leu Tyr Asn Tyr Leu Met Gln Arg Met Leu Val Asn Glu Tyr Thr Lys 
        35                  40                  45              


Lys Ala Asn Asp Phe Lys Val Glu Val Pro Glu Leu Leu Ile Thr Tyr 
    50                  55                  60                  


Lys Asn Asn Leu Asp Lys Tyr Lys Thr Tyr Asp Arg Asn Phe Leu His 
65                  70                  75                  80  


Ile Ile Asn Met Pro Phe Ala Tyr Asn Leu Ala Arg Tyr Lys Asn Leu 
                85                  90                  95      


Thr Ile Glu Asp Ile Phe Tyr Asp Asn Tyr Lys Asp Lys Leu Lys Thr 
            100                 105                 110         


Lys Arg Gly 
        115 


<210>  34
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig6415000192

<400>  34

Val Asn Ser Asp Ala Ser Asp Phe Cys Lys Leu Ile Tyr Val Phe Thr 
1               5                   10                  15      


Arg Phe Leu Asp Gly Lys Glu Ile Asn Ile Leu Leu Asn Ser Leu Ile 
            20                  25                  30          


Lys Lys Phe Gln Asp Ile His Ser Phe Asn Thr Thr Val Lys Lys Leu 
        35                  40                  45              


Ser Glu Asn Asn Leu Ile Ile Asn Ala Asp Tyr Val Asp Asp Tyr Ser 
    50                  55                  60                  


Leu Phe Glu Gln Ser Gly Thr Val Ala Arg Glu Leu Met Leu Ile Lys 
65                  70                  75                  80  


Ser Ile Ser Lys Met Asp Phe Gly Leu Asp Asn Ile Asn Leu Ser Phe 
                85                  90                  95      


Met Tyr Asp Asp Ala Leu Arg Thr Leu Gly Val Ser Asp Glu Asn Leu 
            100                 105                 110         


Pro Glu Val Lys Arg Glu Tyr Phe Gly Lys Thr Lys Asn Leu Ser Ala 
        115                 120                 125             


Tyr Ile Arg Asn Asn Val Leu Glu Asn Arg Arg Phe Lys Tyr Val Ile 
    130                 135                 140                 


Lys Tyr Ile His Pro Ser Asp Val Gln Lys Ile Ala Cys Asn Lys Ala 
145                 150                 155                 160 


Ile Ala Gly Phe Val Leu Asn Arg Met Pro Asp Thr Gln Ile Lys Arg 
                165                 170                 175     


Tyr Tyr Asp Ser Leu Ile Asn Lys Gly Ala Thr Asp Ile Gln Ala Gln 
            180                 185                 190         


Ala Lys Ala Leu Leu Asp Cys Ile Thr Gly Ile Ser Phe Asp Ala Ile 
        195                 200                 205             


Lys Asp Asp Lys His Leu His Lys Ser Lys Glu Lys Ser Pro Gln Arg 
    210                 215                 220                 


Ser Ala Asp Arg Glu Arg Lys Lys Ala Met Leu Thr Leu Tyr Tyr Thr 
225                 230                 235                 240 


Ile Val Tyr Ile Phe Val Lys Gln Met Leu His Ile Asn Ser Leu Tyr 
                245                 250                 255     


Thr Ile Gly Phe Phe Tyr Leu Glu Arg Asp Gln Arg Phe Ile Tyr Ser 
            260                 265                 270         


Arg Ala Lys Lys Glu Asn Lys Asn Pro Ser Lys Asn Ser Tyr Leu Asn 
        275                 280                 285             


Asp Phe Arg Ser Val Thr Ala Tyr Phe Ile Pro Ser Glu Ile Met Lys 
    290                 295                 300                 


Arg Ile Glu Lys Asn Glu Asn Lys Gly Phe Leu Glu Asp Phe Glu Ala 
305                 310                 315                 320 


Leu Trp Asn Ser Cys Gly Lys Thr Ser Arg Leu Arg Lys Glu Asp Val 
                325                 330                 335     


Leu Leu Tyr Ala Arg Tyr Ile Ser Pro Asp His Ala Leu Lys Asn Tyr 
            340                 345                 350         


Lys Met Ile Leu Asn Ser Tyr Arg Asn Lys Ile Ala His Ile Asn Val 
        355                 360                 365             


Ile Met Ser Ala Gly Lys Tyr Thr Gly 
    370                 375         


<210>  35
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig6144000300

<400>  35

Asn Lys Asp Ile Leu Lys Leu Val Ile Gln Glu Leu Pro Glu Thr Gln 
1               5                   10                  15      


Ile Leu Arg Tyr Tyr Ser Thr Ile Gly Lys Asn Lys Thr Thr Ser Ile 
            20                  25                  30          


Asp Glu Met Lys Gln Cys Leu Ile Asp Ala Ile Tyr Asn Phe Asn Ile 
        35                  40                  45              


Asp Asp Thr Leu Asn Ala Ile Gly Asp Ser Arg Val Ile Asn Glu Lys 
    50                  55                  60                  


Lys Glu Gln Ser Lys Ala Ile Ile Asn Leu Tyr Leu Thr Val Ile Tyr 
65                  70                  75                  80  


Leu Val Thr Lys Asn Met Val Lys Ile Asn Thr Arg Phe Ser Ile Ala 
                85                  90                  95      


Phe Ala Cys Leu Glu Arg Asp Tyr Tyr Leu His Phe Gly Gln Pro Asn 
            100                 105                 110         


Gly Lys Leu Leu Tyr Leu Gln Leu Thr Glu Glu 
        115                 120             


<210>  36
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig9118000041

<400>  36

Asp Thr Asp Cys Asp Thr Gln Tyr Glu Leu Phe Asn Gly Asp Asn Pro 
1               5                   10                  15      


Gly Lys Leu Ala Asn Glu Leu Arg Ile Cys Lys Ser Leu Ser Arg Met 
            20                  25                  30          


Lys Pro Glu Met Asp Glu Ile Lys Lys Pro Leu Tyr Lys Asp Ala Leu 
        35                  40                  45              


Asn Ile Leu Asn Ile Gly Asn Glu Glu Phe Asp Glu Asn Thr Phe Glu 
    50                  55                  60                  


Phe Leu Asn Arg Glu Lys Gly Asp His Lys Leu Arg Asn Phe Ile Val 
65                  70                  75                  80  


Asn Asn Val Ile Glu Ser Thr Arg Phe Met Tyr Val Val Lys Tyr Met 
                85                  90                  95      


Asn Pro Ser Asn Cys 
            100     


<210>  37
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Activated_sludge_metagenome_transcript_124486

<400>  37

Met Val Lys Thr Lys Ala Glu Ile His Gln Ile Leu Arg Phe Leu Gly 
1               5                   10                  15      


Thr Ile Arg Gln Cys Leu Ala His Lys Lys Asp Ala Lys Trp Asp Ile 
            20                  25                  30          


Ile Phe Asn Pro Asp Ser Met Ser Asn Glu Phe Lys Thr Leu Ile Asp 
        35                  40                  45              


Ser Tyr Tyr Asn Gly Arg Val Lys Ala Leu Asn Asp Asp Phe Ile Lys 
    50                  55                  60                  


His Asn Arg Ser Ser Ser Leu Pro Ile Leu Phe His Tyr Tyr Gly Ala 
65                  70                  75                  80  


Thr Glu Glu Asn Arg Arg Ala Glu Leu Thr Glu Gly Phe Tyr Asp Phe 
                85                  90                  95      


Ile Ile Lys Arg Glu Asn Lys Asn Met Gly Phe Ser Leu Lys Lys Ile 
            100                 105                 110         


Arg Glu Lys Met Leu Glu Lys Gln Glu Ala Ser Phe Ile Lys Glu Asp 
        115                 120                 125             


Gly Tyr Asn Ser Val Arg His Lys Leu Tyr Ile Leu Met Asp Phe Ile 
    130                 135                 140                 


Ile Tyr Lys Thr Tyr Ala Ala Asp Ile Glu Leu Gln Glu Ser Ile Val 
145                 150                 155                 160 


Ala Thr Leu Arg Ser Asn Leu Thr Asp Glu Asp Lys Glu Ala Thr Tyr 
                165                 170                 175     


Glu Ile Gln Ala Lys Ala Leu Trp Asn Lys Ile Gly Asp Asp Ile Val 
            180                 185                 190         


Lys Lys Leu Met Pro Leu Ile Asp Gly Asn Lys Ile Lys Gly Tyr Lys 
        195                 200                 205             


Asp Glu Lys Ile Glu Ile Lys Lys Glu Trp Leu Lys Asp Val Met Ile 
    210                 215                 220                 


Ser Thr Glu Asn Ala Ser Tyr Met Thr Lys Met Val Tyr Phe Met Thr 
225                 230                 235                 240 


Leu Phe Leu Asp Gly Lys Glu Ile Asn Glu Phe Leu Thr Val Leu Ile 
                245                 250                 255     


Asn Lys Phe Glu Asn Ile Gln Gly Phe Phe Asp Val Leu Gly His Asn 
            260                 265                 270         


Ala Leu Ala Glu Lys Ile Glu Glu Pro Lys Glu Ile Ser Lys Arg Pro 
        275                 280                 285             


Leu Lys Gly Phe Ala Glu Leu Ala Ala Phe Thr Gln Lys Ser Thr Asp 
    290                 295                 300                 


Val Gly Leu Thr Glu His Leu Arg Leu Phe Glu Asn Ser Val Asn Ile 
305                 310                 315                 320 


Ser Asp Glu Ile Arg Val Thr Lys Asn Phe Ala 
                325                 330     


<210>  38
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig1322000437

<400>  38

Ile Asn Glu Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asp Ile Gln 
1               5                   10                  15      


Ser Leu Met Asp Ile Ala Thr Ser Lys Gln Val Asn Val Pro Cys Lys 
            20                  25                  30          


Phe Thr Ser Asp Tyr Ser Ile Phe Asn Asn Ser Ser Arg Ile Val Lys 
        35                  40                  45              


Glu Leu Asn Val Val Lys Asn Val Ala Arg Met Gln Lys Pro Thr Ala 
    50                  55                  60                  


Ser Val Lys Thr Asp Met Leu Met Asp Ala Leu Thr Leu Leu Gly Thr 
65                  70                  75                  80  


Asp Asp Thr Met Asp Ser Glu Lys Leu Arg Asn Tyr Val Arg Val Gln 
                85                  90                  95      


Ile Met Lys Leu Asp Ala Glu Gly Lys Thr Ser Lys Ser Asp Asp His 
            100                 105                 110         


Thr Leu Arg Asn Phe Leu Ile Asn Asn Val Ile Asn Ser Ser Arg Phe 
        115                 120                 125             


Ile Tyr Val Ile Lys Tyr Val Lys Ala Asp Thr Ala Tyr Ala Leu Gly 
    130                 135                 140                 


His Asn Arg Lys Ala Val Ala Tyr Val Leu His Arg Ile Pro Glu Gln 
145                 150                 155                 160 


Gln Ile Asp Arg Tyr Tyr Ser Ser Cys Ile Asp Arg Asp Ala Gly Asn 
                165                 170                 175     


Arg Met Glu Lys Glu Asn Ala Leu Val Asp Met Ile Val Lys Leu Ser 
            180                 185                 190         


Phe Arg Asp Ile Glu Asn Val Ser Asn Asp Asn Glu Lys Ala Ser Glu 
        195                 200                 205             


Lys Gln Arg Tyr Arg Ala Val Val Gly Leu Tyr Leu Thr Val Ile Tyr 
    210                 215                 220                 


Glu Leu Val Lys Asn Ile Val Asn Ile Asn Ser Arg Tyr Val Ile Ala 
225                 230                 235                 240 


Phe His Ser Leu Glu 
                245 


<210>  39
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig4582000531

<400>  39

Ser Asn Asp His Ala Leu Arg Asn Phe Ile Val Asn Asn Val Ile Ser 
1               5                   10                  15      


Ser Ser Arg Phe Thr Tyr Ile Ile Lys Phe Ile Asn Ala Asn Ile Ala 
            20                  25                  30          


Tyr Lys Ile Gly His Asn Arg Lys Ala Val Ser Tyr Val Ile Lys Lys 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile Asp Arg Tyr Phe Thr Ser Cys Ile Gly Gln 
    50                  55                  60                  


Glu Ser Lys Gln Ala Glu Ile Ser Asp Lys Arg Gln Ala Leu Ile Asp 
65                  70                  75                  80  


Met Ile Thr Thr Leu Asp Tyr Tyr Arg Phe Thr Asp Ile Asn Asn Glu 
                85                  90                  95      


Asp Ile Gln Lys Lys Glu Gln Tyr Lys Ala Ile Ile Gly Leu Tyr Leu 
            100                 105                 110         


Thr Val Val Tyr Arg Leu Val Lys Asn Ile Val Asn Ile Asn Ser Arg 
        115                 120                 125             


Tyr Val Ile Ala Phe His Cys Leu Glu Arg Asp 
    130                 135                 


<210>  40
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig9190000283

<400>  40

Phe Val Leu Asn Ser Ile Pro Asp Leu Gln Leu Asp Arg Tyr Tyr Lys 
1               5                   10                  15      


Ala Ile Thr Gly Lys Ser Asp Gly Asn Arg Val Glu Lys Thr Asp Ile 
            20                  25                  30          


Ile Met Asp Lys Leu Met Lys Leu Asp Phe Asn Gln Leu Lys Val Asn 
        35                  40                  45              


Glu Asp Gln Met Gly Lys Lys Asn Ile Tyr Phe Val Glu Lys Leu Lys 
    50                  55                  60                  


Ala Leu Val Gly Leu Tyr Leu Thr Ile Ile Tyr Leu Leu Thr Lys Ser 
65                  70                  75                  80  


Leu Val Lys Ile Asn Ser Ile Tyr Ile Leu Ala Phe Ser Cys Phe Glu 
                85                  90                  95      


Arg Asp Tyr Arg 
            100 


<210>  41
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig1709000510

<400>  41

Pro Lys Phe Lys Ser Gly Ser His Ala Gln Lys Tyr Tyr Gly Phe Ile 
1               5                   10                  15      


Ile Phe Lys Ser His Lys Asn Leu Gly Phe Ser Ile Lys Glu Leu Arg 
            20                  25                  30          


Lys Lys Leu Phe Asp Ile Glu Asp Ala Lys Ala Phe Ser Lys Lys Gln 
        35                  40                  45              


Tyr Asp Ser Val Arg Phe Lys Met Asn Lys Leu Ile Asp Phe Phe Ile 
    50                  55                  60                  


Thr Tyr His Tyr Thr Thr Ile Asp Lys Lys Gln Ala Asp Lys Leu Val 
65                  70                  75                  80  


Ser Lys Leu Arg Tyr Ser Ile Asp Glu Lys Glu Lys Asp Asp Ile Tyr 
                85                  90                  95      


Thr Thr Glu Ala Glu Asp Leu Trp Asn Lys Tyr Lys Ser Ser Phe Glu 
            100                 105                 110         


Gln Ile Arg Ala Tyr Val Ser Pro Asp Ile Ile Thr Glu Tyr Glu His 
        115                 120                 125             


Gln Ala Thr Asn Phe Glu Tyr Glu Ile Lys Lys Phe Asp Pro Ser Thr 
    130                 135                 140                 


Glu Leu Lys Thr Phe Phe Ser Lys Met Ile Tyr Val Leu Cys Met Phe 
145                 150                 155                 160 


Leu Asp Gly Lys Glu Ile Asn Glu Leu Leu Ser Thr Leu Ile Asn Lys 
                165                 170                 175     


Phe Asp Asn Ile Asp Ser Phe Ile Thr Thr Ser Glu Gly Ile Thr Asp 
            180                 185                 190         


Glu Cys Arg Phe Thr Gly Thr Gly Glu Lys Lys Asn Ile Tyr Asp Ile 
        195                 200                 205             


Phe Asn Ala Ser Gly 
    210             


<210>  42
<211>  946
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M24_(LSQX01212483_Anaerobic_digester_metagenome)

<400>  42

Met Asn Asn Lys Arg Lys Thr Lys Ala Lys Ala Ala Gly Leu Lys Ser 
1               5                   10                  15      


Val Phe Phe Asp Gln Lys Gln Ala Val Leu Thr Thr Phe Ala Lys Gly 
            20                  25                  30          


Asn Asn Ser Gln Ile Glu Lys Lys Val Val Asn Ser Glu Val Lys Asp 
        35                  40                  45              


Leu Arg Gln Pro Pro Ala Phe Asp Leu Glu Leu Lys Glu Lys Thr Phe 
    50                  55                  60                  


Tyr Ile Ser Gly Lys Asn Asn Ile Asn Thr Ser Arg Glu Asn Pro Leu 
65                  70                  75                  80  


Ala Ser Ala Ser Leu Pro Leu Ser Lys Arg Gln Arg Ile Arg Ala Glu 
                85                  90                  95      


Arg Ile Lys Arg Ala Arg Glu Glu Asn Arg Pro Tyr His Asn Val Lys 
            100                 105                 110         


Arg Val Gly Glu Asp Asp Leu Arg Ala Lys Ala Asp Leu Glu Lys His 
        115                 120                 125             


Tyr Phe Gly Lys Glu Tyr Ser Asp Asn Leu Lys Ile Gln Ile Ile Tyr 
    130                 135                 140                 


Asn Ile Leu Asp Ile Asn Lys Ile Ile Ser Pro Tyr Ile Asn Asp Ile 
145                 150                 155                 160 


Val Tyr Ser Met Asn Asn Leu Ala Arg Asn Asp Glu Tyr Ile Asp Gly 
                165                 170                 175     


Lys Ile Asp Val Ile Gly Ser Leu Ser Ser Thr Thr Asp Tyr Ser Ser 
            180                 185                 190         


Phe Met Ser Pro Asn Lys Asp Leu Glu Lys Glu Lys Lys Phe Ser Phe 
        195                 200                 205             


His Arg Glu Asn Tyr Lys Lys Phe Val Glu Ala Ser Lys Pro Tyr Met 
    210                 215                 220                 


Arg Tyr Tyr Gly Lys Val Phe Ile Arg Asp Val Lys Lys Ser Lys Leu 
225                 230                 235                 240 


Ser Thr Gly Lys Gly Glu Lys Ile Glu Val Met Tyr Arg Ser Asp Glu 
                245                 250                 255     


Glu Ile Phe Thr Ile Phe Gln Ile Leu Ser Tyr Val Arg Gln Ser Ile 
            260                 265                 270         


Met His Asn Asp Ile Gly Asn Lys Ser Ser Ile Leu Ala Ile Glu Lys 
        275                 280                 285             


Tyr Pro Ala Arg Phe Val Gly Phe Leu Ser Asp Leu Leu Lys Thr Lys 
    290                 295                 300                 


Thr Asn Asp Val Asn Arg Met Phe Ile Asp Asn Asn Ser Gln Thr Asn 
305                 310                 315                 320 


Phe Trp Val Leu Phe Ser Ile Phe Gly Leu Gln Asp His Thr Ser Gly 
                325                 330                 335     


Ala Asp Lys Ile Cys Arg Asn Phe Tyr Asp Phe Val Ile Lys Ala Asp 
            340                 345                 350         


Ser Lys Asn Leu Gly Phe Ser Leu Lys Lys Ile Arg Glu Leu Met Leu 
        355                 360                 365             


Asp Leu Pro Asn Ala Asn Met Leu Arg Asp His Gln Phe Asp Thr Val 
    370                 375                 380                 


Arg Ser Lys Phe Tyr Thr Leu Leu Asp Phe Ile Ile Tyr Gln His Tyr 
385                 390                 395                 400 


Leu Glu Glu Lys Ser Arg Ile Asp Asn Met Val Glu Lys Leu Arg Met 
                405                 410                 415     


Thr Leu Lys Glu Glu Glu Lys Glu Val Leu Tyr Ala Ala Glu Ala Lys 
            420                 425                 430         


Ile Val Trp Asn Ala Ile Gly Ala Lys Val Ile Asn Lys Leu Val Pro 
        435                 440                 445             


Met Met Asn Gly Asp Ala Leu Lys Glu Ile Lys Arg Lys Asn Arg Asp 
    450                 455                 460                 


Arg Lys Leu Pro Gln Ser Val Ile Ala Thr Val Gln Val Asn Ser Asp 
465                 470                 475                 480 


Ala Asn Val Phe Ser Gly Leu Ile Tyr Phe Leu Thr Leu Phe Leu Asp 
                485                 490                 495     


Gly Lys Glu Ile Asn Glu Met Val Ser Asn Leu Ile Thr Lys Phe Glu 
            500                 505                 510         


Asn Ile Asp Ser Leu Leu His Val Asp Arg Glu Ile Tyr Lys Ser Asp 
        515                 520                 525             


Glu Lys Asp Leu Asp Leu Glu Ile Glu Lys Leu Ala Leu Phe Phe Lys 
    530                 535                 540                 


Gly Val Val Arg Pro Asn Ala Lys Thr Asp Thr Gly Ala Gly Glu Ile 
545                 550                 555                 560 


Ser Lys Ser Phe Ser Ile Phe Gln Ser Ala Glu Arg Ile Ile Glu Glu 
                565                 570                 575     


Leu Lys Phe Ile Lys Asn Val Thr Arg Met Asp Asn Glu Ile Phe Pro 
            580                 585                 590         


Ser Glu Gly Val Phe Leu Asp Ala Ala Asn Val Leu Gly Val Arg Gly 
        595                 600                 605             


Asp Asp Phe Asp Phe Ser Asn Glu Phe Val Gly Asp Asp Leu His Ser 
    610                 615                 620                 


Asp Ala Asn Lys Lys Ile Ile Asn Lys Ile Asn Gly Thr Lys Glu Asp 
625                 630                 635                 640 


Arg Asn Leu Arg Asn Phe Ile Ile Asn Asn Val Val Lys Ser Arg Arg 
                645                 650                 655     


Phe Gln Tyr Ile Ala Arg His Met Asn Thr His Tyr Val Lys Gln Leu 
            660                 665                 670         


Ala Asn Asn Glu Thr Leu Asn Arg Phe Val Leu Asn Lys Met Gly Asp 
        675                 680                 685             


Ala Lys Ile Ile Asn Arg Tyr Tyr Glu Ser Ile Ser Gly Asn Thr Pro 
    690                 695                 700                 


Asn Ile Glu Val Arg Ser Gln Ile Asp Tyr Leu Val Lys Arg Leu Arg 
705                 710                 715                 720 


Ser Phe Ser Phe Glu Asp Leu Asn Asp Val Lys Gln Lys Val Arg Pro 
                725                 730                 735     


Gly Thr Asn Glu Ser Ile Glu Lys Glu Lys Lys Lys Ala Leu Val Gly 
            740                 745                 750         


Leu Cys Leu Thr Ile Gln Tyr Leu Val Tyr Lys Asn Leu Val Asn Ile 
        755                 760                 765             


Asn Ala Arg Tyr Thr Thr Ala Phe Tyr Cys Leu Glu Arg Asp Ser Lys 
    770                 775                 780                 


Leu Lys Gly Phe Gly Val Asp Val Trp Arg Asp Phe Glu Ser Tyr Thr 
785                 790                 795                 800 


Ala Leu Thr Asn His Phe Ile Lys Glu Gly Tyr Leu Pro Val Arg Lys 
                805                 810                 815     


Ala Glu Ile Leu Arg Ala Asn Leu Lys His Leu Asp Cys Glu Asp Gly 
            820                 825                 830         


Phe Lys Tyr Tyr Arg Asn Gln Val Thr His Leu Asn Ala Ile Arg Val 
        835                 840                 845             


Ala Tyr Lys Tyr Ile Asn Glu Ile Lys Ser Val His Ser Tyr Phe Ala 
    850                 855                 860                 


Leu Tyr His Tyr Ile Met Gln Arg His Leu Tyr Asp Ser Leu Gln Ala 
865                 870                 875                 880 


Lys Ala Lys Asp Ser Ser Gly Phe Val Ile Asp Ala Leu Lys Lys Ser 
                885                 890                 895     


Phe Glu His Lys Ile Tyr Ser Lys Asp Leu Leu His Val Leu His Ser 
            900                 905                 910         


Pro Phe Gly Tyr Asn Thr Ala Arg Tyr Lys Asn Leu Ser Ile Glu Ala 
        915                 920                 925             


Leu Phe Asp Lys Asn Glu Ser Arg Pro Glu Val Asn Pro Leu Ser Thr 
    930                 935                 940                 


Asn Asp 
945     


<210>  43
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig3833000494

<400>  43

Glu Glu Ala Ser Asp Phe Lys Asp Lys Lys Asn Asp Ser Asp Arg Arg 
1               5                   10                  15      


Lys Leu Tyr Lys Leu Met Asp Phe Cys Ile Phe Tyr Leu Tyr Tyr Ser 
            20                  25                  30          


Asp Ser Lys Arg Asn Glu Asp Leu Val Ser Arg Leu Arg Glu Ser Leu 
        35                  40                  45              


Thr Asp Glu Asn Lys Asp Ile Ile Tyr Ser Lys Glu Ala Lys Thr Val 
    50                  55                  60                  


Trp Asn Glu Leu Arg Lys Lys Phe Ser Thr Ile Leu Asp Asn Val Lys 
65                  70                  75                  80  


Gly Ala Asn Ile Lys Lys Leu Glu Asp Val Lys Glu Lys Phe Ile Ser 
                85                  90                  95      


Glu Asp Glu Phe Asp Asp Ile Lys Leu Asp Ile Asp Ile Ser Tyr Phe 
            100                 105                 110         


Ser Lys Leu Met Tyr Val Met Cys Tyr Phe Leu Asp Gly Lys Lys Ile 
        115                 120                 125             


Asn Asp Leu Leu Thr Thr Leu Val Ser Lys Phe Asp Asn Ile Gly Ser 
    130                 135                 140                 


Ile Ile Glu Ala Ala Lys 
145                 150 


<210>  44
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Activated_sludge_metagenome_transcript_117355

<400>  44

Met Glu Lys Met Glu Lys Ile Arg Lys Ser Glu Asn Arg Lys Ser Arg 
1               5                   10                  15      


Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Val Val Ala Asp Lys Leu 
            20                  25                  30          


Ala Leu Thr Ser Phe Gly Lys Gly Asn Lys Ala Asn Leu Glu Lys Ile 
        35                  40                  45              


Ile Lys Asn Glu Glu Val Glu Glu Ile Asn Lys Pro Pro Lys Phe Asp 
    50                  55                  60                  


Ala Lys Val Glu Glu Lys Gln Ile His Ile Ile Gly Lys Thr Ile Lys 
65                  70                  75                  80  


Asp Gly Ile Thr Glu Lys Pro Ala Gly Met Arg Asn Asp Leu Ile Gly 
                85                  90                  95      


Ala Lys Gln Glu Leu Glu Lys Met Phe Phe Gly Lys Thr Phe Asp Asp 
            100                 105                 110         


Asn Ile His Ile Gln Leu Ile Tyr Asn Ile Leu 
        115                 120             


<210>  45
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig11061000330

<400>  45

Ser Gln Arg Asp Ser Thr Ile Asn Pro Gly Glu Lys Gln Ile Ser Val 
1               5                   10                  15      


Glu Lys Leu Asn Pro Lys Met Val Gln Tyr Ala Lys Ala Val Ile Asn 
            20                  25                  30          


His Gly Thr Tyr Cys Lys Asp Ala Val Lys Ala Leu Cys Val Pro Phe 
        35                  40                  45              


Ala Tyr Gln Leu Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe 
    50                  55                  60                  


Asp Lys Asn His Pro Gly Asp Lys Lys Glu Ala Lys Thr Leu Ala Leu 
65                  70                  75                  80  


Asp Asp Asp Val 
                


<210>  46
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig338000322

<400>  46

Phe Asp Asn Ile Ile Ser Phe Ile Asp Ile Leu Lys Lys Leu Asn Leu 
1               5                   10                  15      


Glu Phe Lys Phe Lys Pro Glu Tyr Ala Asp Phe Phe Asn Met Thr Asn 
            20                  25                  30          


Cys Arg Tyr Thr Leu Glu Glu Leu Arg Val Ile Asn Ser Ile Ala Arg 
        35                  40                  45              


Met Gln Lys Pro Ser Ala Asp Ala Arg Lys Ile Met Tyr Arg Asp Ala 
    50                  55                  60                  


Leu Arg Ile Leu Gly Met Asp Asn Arg Pro Asp Glu Glu Ile Asp Arg 
65                  70                  75                  80  


Glu Leu Glu Arg Thr Met Pro Val Gly Ala Asp Gly Lys Phe Ile Lys 
                85                  90                  95      


Gly Lys Gln Gly Phe Arg Asn Phe Ile Ala Ser Asn Val Ile Glu Ser 
            100                 105                 110         


Ser Arg Phe His Tyr Leu Val Arg Tyr Asn Asn Pro His Lys Thr Arg 
        115                 120                 125             


Thr Leu Val Lys Asn Pro Asn Val Val Lys Phe Val Leu Glu Gly Ile 
    130                 135                 140                 


Pro Glu Thr Gln Ile Lys Arg Tyr Phe Asp Val Cys Lys Gly Gln Glu 
145                 150                 155                 160 


Ile Pro Pro Thr Ser Asp Lys Ser Ala Gln Ile Asp Val Leu Ala Arg 
                165                 170                 175     


Ile Ile Ser Ser Val Asp Tyr Lys Ile Phe Glu Asp Val Pro Gln Ser 
            180                 185                 190         


Ala Lys Ile Asn Lys Asp Asp Pro Ser Arg Asn Phe Ser Asp Ala Leu 
        195                 200                 205             


Lys Lys Gln Arg Tyr Gln Ala Ile Val Ser Leu Tyr Leu Thr Val Met 
    210                 215                 220                 


Tyr Leu Ile Thr Lys Asn Leu Val Tyr Val Asn Ser Arg Tyr Val Ile 
225                 230                 235                 240 


Ala Phe His Cys Leu Glu Arg Asp Ala Phe Leu His Gly Val Thr Leu 
                245                 250                 255     


Pro Lys Met Asn Lys Lys Ile Val Tyr Ser Gln Leu Thr Thr His Leu 
            260                 265                 270         


Leu Thr Asp Lys Asn Tyr Thr Thr Tyr Gly His Leu Lys Asn Gln Lys 
        275                 280                 285             


Gly His Arg Lys Trp Tyr Val Leu Val Lys Asn Asn Leu Gln Asn Ser 
    290                 295                 300                 


Asp Ile Thr Ala Val Ser Ser Phe Arg Asn Ile Val Ala His Ile Ser 
305                 310                 315                 320 


Val Val Arg Asn Ser Asn Glu Tyr Ile Ser Gly Ile Gly Glu Leu His 
                325                 330                 335     


Ser Tyr Phe Glu Leu Tyr His Tyr Leu Val Gln Ser Met Ile Ala Lys 
            340                 345                 350         


Asn Asn Trp Tyr Asp Thr Ser His Gln Pro Lys Thr Ala Glu Tyr Leu 
        355                 360                 365             


Asn Asn Leu Lys Lys His His Thr Tyr Cys Lys Asp Phe Val Lys Ala 
    370                 375                 380                 


Tyr Cys Ile Pro Phe Gly Tyr Val Val Pro Arg Tyr Lys Asn Leu Thr 
385                 390                 395                 400 


Ile Asn Glu Leu Phe Asp Arg Asn Asn Pro Asn Pro Glu Pro Lys Glu 
                405                 410                 415     


Glu Val 
        


<210>  47
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  exemplary Cas13d sequence from human gut metagenome

<400>  47

Phe Asp Asn Ile Ile Ser Phe Ile Asp Ile Leu Lys Lys Leu Asn Leu 
1               5                   10                  15      


Glu Phe Lys Phe Lys Pro Glu Tyr Ala Asp Phe Phe Asn Met Thr Asn 
            20                  25                  30          


Cys Arg Tyr Thr Leu Glu Glu Leu Arg Val Ile Asn Ser Ile Ala Arg 
        35                  40                  45              


Met Gln Lys Pro Ser Ala Asp Ala Arg Lys Ile Met Tyr Arg Asp Ala 
    50                  55                  60                  


Leu Arg Ile Leu Gly Met Asp Asn Arg Pro Asp Glu Glu Ile Asp Arg 
65                  70                  75                  80  


Glu Leu Glu Arg Thr Met Pro Val Gly Ala Asp Gly Lys Phe Ile Lys 
                85                  90                  95      


Gly Lys Gln Gly Phe Arg Asn Phe Ile Ala Ser Asn Val Ile Glu Ser 
            100                 105                 110         


Ser Arg Phe His Tyr Leu Val Arg Tyr Asn Asn Pro His Lys Thr Arg 
        115                 120                 125             


Thr Leu Val Lys Asn Pro Asn Val Val Lys Phe Val Leu Glu Gly Ile 
    130                 135                 140                 


Pro Glu Thr Gln Ile Lys Arg Tyr Phe Asp Val Cys Lys Gly Gln Glu 
145                 150                 155                 160 


Ile Pro Pro Thr Ser Asp Lys Ser Ala Gln Ile Asp Val Leu Ala Arg 
                165                 170                 175     


Ile Ile Ser Ser Val Asp Tyr Lys Ile Phe Glu Asp Val Pro Gln Ser 
            180                 185                 190         


Ala Lys Ile Asn Lys Asp Asp Pro Ser Arg Asn Phe Ser Asp Ala Leu 
        195                 200                 205             


Lys Lys Gln Arg Tyr Gln Ala Ile Val Ser Leu Tyr Leu Thr Val Met 
    210                 215                 220                 


Tyr Leu Ile Thr Lys Asn Leu Val Tyr Val Asn Ser Arg Tyr Val Ile 
225                 230                 235                 240 


Ala Phe His Cys Leu Glu Arg Asp Ala Phe Leu His Gly Val Thr Leu 
                245                 250                 255     


Pro Lys Met Asn Lys Lys Ile Val Tyr Ser Gln Leu Thr Thr His Leu 
            260                 265                 270         


Leu Thr Asp Lys Asn Tyr Thr Thr Tyr Gly His Leu Lys Asn Gln Lys 
        275                 280                 285             


Gly His Arg Lys Trp Tyr Val Leu Val Lys Asn Asn Leu Gln Asn Ser 
    290                 295                 300                 


Asp Ile Thr Ala Val Ser Ser Phe Arg Asn Ile Val Ala His Ile Ser 
305                 310                 315                 320 


Val Val Arg Asn Ser Asn Glu Tyr Ile Ser Gly Ile Gly Glu Leu His 
                325                 330                 335     


Ser Tyr Phe Glu Leu Tyr His Tyr Leu Val Gln Ser Met Ile Ala Lys 
            340                 345                 350         


Asn Asn Trp Tyr Asp Thr Ser His Gln Pro Lys Thr Ala Glu Tyr Leu 
        355                 360                 365             


Asn Asn Leu Lys Lys His His Thr Tyr Cys Lys Asp Phe Val Lys Ala 
    370                 375                 380                 


Tyr Cys Ile Pro Phe Gly Tyr Val Val Pro Arg Tyr Lys Asn Leu Thr 
385                 390                 395                 400 


Ile Asn Glu Leu Phe Asp Arg Asn Asn Pro Asn Pro Glu Pro Lys Glu 
                405                 410                 415     


Glu Val 
        


<210>  48
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig9530000097

<400>  48

Lys Ser Lys His Tyr Arg Gln Cys Val Lys Glu Asp Leu Leu Asn Ala 
1               5                   10                  15      


Arg Lys Leu His Thr Asp Asp Tyr Asn Ile Asp Ala Ile Arg Ala Phe 
            20                  25                  30          


Arg Asn Ala Val Ala His Leu Asp Val Val Arg Asn Met Ser Ala Tyr 
        35                  40                  45              


Ile Glu Gly Ile Arg Glu Ile Asn Ser Tyr Tyr Gly Leu Tyr His Tyr 
    50                  55                  60                  


Leu Ala Gln Arg Cys Leu Gln Lys Arg Cys Asn Gly Ala Leu Asp Asp 
65                  70                  75                  80  


Asn Thr Asp Tyr Phe Arg Thr Leu Asp Lys Tyr Asn Thr Tyr Val Lys 
                85                  90                  95      


Asp Phe Val Lys Ala Leu Cys Val Pro Phe Ala Tyr Asn 
            100                 105                 


<210>  49
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig1750000258

<400>  49

Ser Thr Pro Asp Lys Ala Arg Glu Ser Leu Arg Asp Met Leu His Asn 
1               5                   10                  15      


Ile Ser Phe Asn Asp Phe Ala Asp Val Lys Gln Asp Asp Arg Arg Ala 
            20                  25                  30          


Thr Pro Glu Glu Lys Val Glu Lys Glu Arg Tyr Lys Ala Ile Ile Gly 
        35                  40                  45              


Leu Tyr Leu Thr Val Met Tyr His Leu Val Lys Asn Leu Val Tyr Val 
    50                  55                  60                  


Asn Ser Arg Tyr Val Met Ala Phe His Cys Leu Glu Arg Asp Ala Met 
65                  70                  75                  80  


His Tyr Asp Val Cys Leu Asp Asn Tyr Arg Asp Leu Ile Arg His Leu 
                85                  90                  95      


Ile Ser Asp Gly Asp Ser Ser Cys Asn His Phe Ile Ser His Asn Lys 
            100                 105                 110         


Arg Met Arg Gly Cys Ile Glu Glu Asp Val Asn Asn Ser Glu Gln Leu 
        115                 120                 125             


Ile Phe Gly Lys Glu Asp Ala Val Ile Arg Phe Arg Asn Asn Val Ala 
    130                 135                 140                 


His Leu Ser Ala Ile Arg Asn Ala Asn Glu Tyr Ile Asp Asp Ile Arg 
145                 150                 155                 160 


Glu Ile Thr Ser Tyr Phe Ala Leu Tyr His Tyr Leu Met Gln Arg Lys 
                165                 170                 175     


Leu Ile Asp Asp Cys Lys Val Asn Asp Thr Ala His Lys Tyr Phe Glu 
            180                 185                 190         


Lys Leu Thr Lys Tyr Lys Thr Tyr Val Met Asp Met Val Lys Ala Leu 
        195                 200                 205             


Cys Ser Pro Phe Gly 
    210             


<210>  50
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig5377000274

<400>  50

Lys Glu Asn Asp Ile Leu Lys Lys Ser Arg Lys Lys Ser Ser Val Lys 
1               5                   10                  15      


Ala Asn Gly Leu Lys Ser Val Phe Val Met Glu Asn Lys Ala Leu Met 
            20                  25                  30          


Thr Ser Phe Gly Lys Gly Asn Lys Ala Asn Pro Glu Lys Glu Leu Val 
        35                  40                  45              


Gly Gly Glu Ile Arg Glu Leu Thr Asp Ser Pro Val Phe Asp Ala Ser 
    50                  55                  60                  


Asn Leu Gly Asn Ile Ile Glu Ile Ser Arg Arg Gly Val Arg Ile Glu 
65                  70                  75                  80  


Lys Lys Gly Tyr Ile Ala Ser Asp Tyr Glu Ile His Lys Asp Val Ile 
                85                  90                  95      


Asn Ala Lys Asp Lys Leu Glu Glu Arg Tyr Phe Gly Ser Ala Met Asp 
            100                 105                 110         


Asp Asn Ile His Ile Gln Met Val Tyr Gln Ile Leu Asp Ile Glu Lys 
        115                 120                 125             


Ile Leu Ser 
    130     


<210>  51
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  gut_metagenome_P19E0k2120140920_c248000089

<400>  51

Tyr Ser Ala Asp Met Ile Asp Glu Leu Ala Gly Ile Ile His Asp Met 
1               5                   10                  15      


Lys Phe Lys Gln Phe Glu Asn Val Asp Gln Ser Ala Lys Arg Gly Thr 
            20                  25                  30          


Pro Glu Ala Ala Asp Lys Gln Gln Lys Gln Asn Val Ile Arg Leu Tyr 
        35                  40                  45              


Leu Thr Val Cys Tyr Leu Phe Phe Lys Asn Leu Ile Tyr Val Asn Ser 
    50                  55                  60                  


Arg Tyr Phe Leu Ala Phe Tyr Cys Leu Glu Arg Asp Val Lys Leu Trp 
65                  70                  75                  80  


Gly Lys Thr Pro Lys Phe Gly Ser Arg Glu Glu Asp Thr Ser Tyr Thr 
                85                  90                  95      


Val Leu Thr Arg Glu Phe Met Asp Ser Gly Lys Ile Ser Thr Lys Ser 
            100                 105                 110         


Lys Ser Lys Asn Gly Ala Glu Ser Pro Asp Glu Ala Ala Lys His Ile 
        115                 120                 125             


Pro Arg Asn Tyr Ile Gln Lys Asn Leu Asp Asn Ser Asp Asp Val Ala 
    130                 135                 140                 


Ile Arg Tyr Phe Arg Asn Ala Ala Glu His Ile Asn Ala Leu Gln Cys 
145                 150                 155                 160 


Ala Ala Asn Tyr Leu Glu Asn Val Glu Asp Thr Glu Ser Tyr Tyr Arg 
                165                 170                 175     


Ile Tyr His Tyr Ile Met Gln Arg Tyr Ile Met Gln Ser Tyr Ser Gln 
            180                 185                 190         


Asp Lys Ser Gly Gly Lys Tyr Asp Lys Ala Asp Ala Arg Asp Ile Asn 
        195                 200                 205             


Asp Lys Thr Lys Glu Tyr Phe Glu Leu Val Glu Asn His Asn Thr Tyr 
    210                 215                 220                 


Cys Lys Asp Phe Val Lys Ala Leu Cys Val Pro Phe Ala Tyr Asn Leu 
225                 230                 235                 240 


Ala Arg Phe Lys Asn Leu Ser Ile Asp Gly Leu Phe Asp Lys Asn 
                245                 250                 255 


<210>  52
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig11400000031

<400>  52

Asn Ile Val Lys His Val Leu Lys Asp Ile Pro Asp Thr Gln Ile Glu 
1               5                   10                  15      


Arg Tyr Tyr Lys Ser Tyr Phe Asn Thr Glu Asn Ala Ala Asn Ala Glu 
            20                  25                  30          


Ile Met Arg Glu Lys Leu Ala Ser Ala Leu Met Gln Val Lys Tyr Asp 
        35                  40                  45              


Glu Phe Lys Asn Val Lys Gln Lys Val Lys Asn Gly Thr Glu Glu Ala 
    50                  55                  60                  


Phe Glu Lys Glu Arg Lys Lys Ala Leu Val Arg Leu Tyr Leu Thr Val 
65                  70                  75                  80  


Val Tyr Ile Phe Val Lys Asn Leu Val 
                85                  


<210>  53
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig7940000191

<400>  53

Asn His Ile Asp His Leu Asn Ala Val Arg Asn Ala Asp Lys Tyr Leu 
1               5                   10                  15      


Asn Asp Val Arg Gln Val Thr Ser Trp Tyr Glu Leu Phe His Tyr Ile 
            20                  25                  30          


Val Gln Arg Ala Leu Phe Asp Asp Tyr Leu Lys Ala Leu Ser Tyr Asn 
        35                  40                  45              


Pro Asp Ala Gly Lys Glu Leu Asn Pro Arg Thr Leu Glu Tyr Phe Ala 
    50                  55                  60                  


Lys Val Gln Lys Tyr Gly Thr Cys Cys Lys Asp Phe Ile Lys Ala Leu 
65                  70                  75                  80  


Asn Val Pro Phe Ala Tyr Asn Leu Pro Arg Tyr Lys Asn Leu Ser Ile 
                85                  90                  95      


Asp Gly Leu Phe Asp Met Asn Arg Pro Gly Glu Lys Gly 
            100                 105                 


<210>  54
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig6049000251

<400>  54

Leu Tyr Leu Thr Ser Phe Gly Lys Gly Asn Ala Ala Val Ile Glu Gln 
1               5                   10                  15      


Lys Ile Glu Pro Glu Asn Gly Tyr Arg Val Thr Gly Met Gln Ile Thr 
            20                  25                  30          


Pro Ser Ile Thr Val Asn Lys Ala Thr Asp Glu Ser Val Arg Phe Arg 
        35                  40                  45              


Val Lys Arg Lys Ile Ala Gln Lys Asp Glu Phe Ile Ala Asp Asn Pro 
    50                  55                  60                  


Met His Glu Gly Arg His Arg Ile Glu Pro Ser Ala Gly Ser Asp Met 
65                  70                  75                  80  


Leu Gly Leu Lys Thr Lys Leu Glu Lys Tyr Tyr Phe Gly Lys Glu Phe 
                85                  90                  95      


Asp Asp Asn Leu His Ile Gln Ile Ile Tyr Asn Ile Leu Asp Ile Glu 
            100                 105                 110         


Lys Ile Leu Ala Val Tyr Ser Thr Asn Ile Thr Ala 
        115                 120                 


<210>  55
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig1137000500

<400>  55

Met Lys Lys Lys Lys Asn Leu Arg Glu Gln Arg Glu Ala Lys Lys Gln 
1               5                   10                  15      


Glu Arg Leu Ala Ala Cys Ser Ala Lys Thr Lys Ala Ala Glu Ile Pro 
            20                  25                  30          


Ala Ala Glu Lys Pro Val Ala Thr Thr Pro Ile Ala Glu Pro Val Lys 
        35                  40                  45              


Thr Asp Ser Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Leu Lys Ser 
    50                  55                  60                  


Thr Leu Val Leu Asp Asn Lys Leu Tyr Thr Thr Ser Phe Gly Lys Gly 
65                  70                  75                  80  


Asn Glu Ala Val Ile Glu Gln Glu Val Asn Thr Ala Asp Tyr Thr Val 
                85                  90                  95      


Ala Asn Val Asn Ser Thr Pro Ser Leu Glu Ile Arg Ser Ala Gly Asp 
            100                 105                 110         


Lys Glu Leu Ser Phe Ser Ser His Arg Gln Phe Val Asn Lys Asp Glu 
        115                 120                 125             


Leu Ser Ala Val Asn Pro Leu Tyr Gly Gly Lys Asp Lys Pro Arg Lys 
    130                 135                 140                 


Pro Ala Gly Lys Asp Met Leu Gly Leu Lys Asp Lys Leu Glu Glu Arg 
145                 150                 155                 160 


Tyr Phe Gly Lys Ser Phe Asn Asp Asn Ile His Ile Gln Ile Ile Tyr 
                165                 170                 175     


Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Ala Thr Asn Ile 
            180                 185                 190         


Thr Val Ala Leu Asp His Met Ile Asp Lys Asp Val Asn Ile Glu Lys 
        195                 200                 205             


Glu Asp Phe Ile Gly Tyr Met Asn Thr Leu Asn Thr Tyr Glu Val Phe 
    210                 215                 220                 


Met Asp Pro Ser Lys Asn Pro Lys Leu 
225                 230             


<210>  56
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig9368000105

<400>  56

Gln Arg His Val Ala Glu Gly Val Glu Pro Asn Arg His Asp Phe Ala 
1               5                   10                  15      


Glu Arg Phe Pro Tyr Tyr Ala Ala Leu Tyr Gln Tyr His Ser Tyr Val 
            20                  25                  30          


Lys Asp Phe Val Lys Ala Leu Asn Ala Pro Phe Gly Tyr Asn Ile Pro 
        35                  40                  45              


Arg Phe Lys Asn Leu Thr Ile Glu Glu Leu Phe Asp Arg Asn Ile His 
    50                  55                  60                  


Ile Glu Thr Tyr Val 
65                  


<210>  57
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig546000275

<400>  57

Met Asp Ser Tyr Arg Pro Lys Leu Tyr Lys Leu Ile Asp Phe Cys Ile 
1               5                   10                  15      


Phe Lys His Tyr His Glu Tyr Thr Glu Ile Ser Glu Lys Asn Val Asp 
            20                  25                  30          


Thr Leu Arg Ala Ala Val Ser Glu Glu Gln Lys Glu Ser Phe Tyr Ala 
        35                  40                  45              


Asp Glu Ala Lys Arg Leu Trp Gly Ile Phe Asp Lys Gln Phe Leu Gly 
    50                  55                  60                  


Phe Cys Lys Lys Ile Asn Val Trp Val Asn Gly Ser His Glu Lys Glu 
65                  70                  75                  80  


Ile Leu Gly Tyr Ile Asp Lys Asp Ala Tyr Arg Lys Lys Ser Asp Val 
                85                  90                  95      


Ser Tyr Phe Ser Lys Phe Leu Tyr Ala Met Ser Phe Phe Leu Asp Gly 
            100                 105                 110         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn 
        115                 120                 125             


Ile Ala Ser Phe Ile Ser Thr Ala Lys Glu Leu Asp Ala Glu Ile Asp 
    130                 135                 140                 


Arg Ile Leu Glu Lys Lys Leu Asp Pro Val Thr Gly Lys Pro Leu Lys 
145                 150                 155                 160 


Gly Lys Asn Ser Phe Arg Asn Phe Ile Ala Asn Asn Val Ile Glu Asn 
                165                 170                 175     


Lys Arg Phe Ile Tyr Val Ile Lys Phe Cys Asn Pro Lys Asn Val Leu 
            180                 185                 190         


Lys Leu Val Lys Asn Thr Lys Val Thr Glu Phe Val Leu Lys Arg Met 
        195                 200                 205             


Pro Glu Ser Gln Ile Asp Arg Tyr Tyr Ser Ser Cys Ile Asp Thr Glu 
    210                 215                 220                 


Lys Asn Pro Ser Val Asp Lys Lys Ile Ser Asp Leu Ala Glu Met Ile 
225                 230                 235                 240 


Lys Lys Ile Ala Phe Asp Asp Phe Arg Asn Val Arg Gln Lys Thr Arg 
                245                 250                 255     


Thr Arg Glu Glu Ser Leu Glu Lys Glu Arg Phe Lys Ala Val Ile Gly 
            260                 265                 270         


Leu Tyr Leu Thr Val Val Tyr Leu Leu Ile Lys Asn Leu Val Asn Val 
        275                 280                 285             


Asn Ser Arg Tyr Val Met Ala Phe His Cys Leu Glu Arg Asp Ala Lys 
    290                 295                 300                 


Leu Tyr Gly Ile Asn Ile Gly Lys Asn Tyr Ile Glu Leu Thr Glu Asp 
305                 310                 315                 320 


Leu Cys Arg Glu Asn Glu Asn Ser Arg Ser Ala Tyr Leu Ala Arg Asn 
                325                 330                 335     


Lys Arg Leu Arg Asp Cys Val Lys Gln Asn Ile Asp Asn Ala Lys Asn 
            340                 345                 350         


Met Lys Ser Lys Glu Lys 
        355             


<210>  58
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig7216000573

<400>  58

Lys Glu Met Ile Tyr Ala Asn Glu Ala Thr Phe Leu Trp Asp Lys Leu 
1               5                   10                  15      


Gly Arg Thr Phe Leu Asn Phe Cys Asp Asn Ile Gly Ala Trp Val Lys 
            20                  25                  30          


Asn Asp His Thr Glu Glu Ile Glu Thr Tyr Ile Asp Lys Asp Ala Tyr 
        35                  40                  45              


Lys Thr Ser Ser Lys Val Ser Tyr Phe Ser Lys Leu Leu Tyr Ala Met 
    50                  55                  60                  


Cys Phe Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu 
65                  70                  75                  80  


Ile Asn Lys Phe Asp Asn Ile Gly Ser Phe Ile Glu Thr Ala Lys Glu 
                85                  90                  95      


Leu Gly Leu Ser Val Thr Phe Ile Lys Asp Tyr Ala Phe Phe Asn Ala 
            100                 105                 110         


Ser Lys 
        


<210>  59
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig4806000409

<400>  59

Leu Ile Asp Ser Lys Arg Leu Arg Tyr Phe Gly Phe Glu Tyr Asp Pro 
1               5                   10                  15      


Asp Gly Lys Asn Lys Asn Glu Glu Met Lys Lys Arg Leu Tyr His Leu 
            20                  25                  30          


Val Ala Phe Ala Gly Gln Leu Arg Gln Trp Ser Phe His Ser Glu Gly 
        35                  40                  45              


Asn Phe Gln Leu Glu Trp Leu Tyr Lys Leu Asp Asp Ser Arg Ile Ala 
    50                  55                  60                  


Gln Glu Tyr Arg Asp Thr Leu Asp Tyr Phe Phe Asp Arg Arg Phe Asp 
65                  70                  75                  80  


Glu Leu Asn Asn Asn Phe Val Glu Gln Asn Ala Thr Asn Leu Phe Ile 
                85                  90                  95      


Leu Lys Glu Thr Phe Pro Gly Glu Asp Leu Lys Ala Val Thr Asp Leu 
            100                 105                 110         


Tyr Tyr Asp Phe Ile Ile Val Lys Ser Gln Lys Asn Ile Gly Phe Ser 
        115                 120                 125             


Ile Lys Lys Leu Arg Glu Lys Met 
    130                 135     


<210>  60
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig10762000480

<400>  60

Cys Phe Asp Thr Glu Leu Asn Pro Met Thr Glu Ile Lys Ile Gln Asn 
1               5                   10                  15      


Leu Ala Gln Lys Met Lys Asp Met Asp Phe Thr Asn Phe Arg Asp Val 
            20                  25                  30          


Gln Gln Lys Ser Arg Asp Pro Glu Lys Asn Arg Glu Lys Glu Arg Phe 
        35                  40                  45              


Lys Ala Ile Ile Gly Leu Tyr Leu Thr Val Val Tyr Arg Leu Val Lys 
    50                  55                  60                  


Asn Leu Ala Asp Val Asn Ala Arg Tyr Val Met Ala Phe His Ser Leu 
65                  70                  75                  80  


Glu Arg Asp Ser Ser Leu Tyr Asn Glu Pro Val Val Trp Lys 
                85                  90                  


<210>  61
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig4114000374

<400>  61

Asp Thr Lys Ile Asn Pro Gln Thr Trp Leu Tyr Gln Leu Glu Asn Thr 
1               5                   10                  15      


Pro Asp Leu Asp Asn Glu Tyr Arg Asp Thr Leu Asp His Phe Phe Asp 
            20                  25                  30          


Glu Arg Phe Asn Glu Ile Asn Glu His Phe Val Thr Gln Asn Ala Thr 
        35                  40                  45              


Asn Leu Cys Ile Met Lys Glu Val Phe Pro Asp Glu Asp Phe Lys Ser 
    50                  55                  60                  


Ile Ala Asp Leu Tyr Tyr Asp Phe Ile Val Val Lys Ser Tyr Lys Asn 
65                  70                  75                  80  


Ile Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Glu Leu Pro 
                85                  90                  95      


Glu Ala Lys Arg Val Thr Ser Thr Glu Met Asp Ser Val Arg Ser Lys 
            100                 105                 110         


Leu Tyr Lys Leu Ile Asp Phe Cys Ile Phe Lys His Tyr His Glu Lys 
        115                 120                 125             


Pro Glu Thr Val Glu Met Ile Val Ser Met Leu Arg Ala Tyr Thr Ser 
    130                 135                 140                 


Glu Asp Met Lys Glu 
145                 


<210>  62
<211>  933
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ruminococcus_flavefaciens_FD1

<400>  62

Met Lys Lys Lys Met Ser Leu Arg Glu Lys Arg Glu Ala Glu Lys Gln 
1               5                   10                  15      


Ala Lys Lys Ala Ala Tyr Ser Ala Ala Ser Lys Asn Thr Asp Ser Lys 
            20                  25                  30          


Pro Ala Glu Lys Lys Ala Glu Thr Pro Lys Pro Ala Glu Ile Ile Ser 
        35                  40                  45              


Asp Asn Ser Arg Asn Lys Thr Ala Val Lys Ala Ala Gly Leu Lys Ser 
    50                  55                  60                  


Thr Ile Ile Ser Gly Asp Lys Leu Tyr Met Thr Ser Phe Gly Lys Gly 
65                  70                  75                  80  


Asn Ala Ala Val Ile Glu Gln Lys Ile Asp Ile Asn Asp Tyr Ser Phe 
                85                  90                  95      


Ser Ala Met Lys Asp Thr Pro Ser Leu Glu Val Asp Lys Ala Glu Ser 
            100                 105                 110         


Lys Glu Ile Ser Phe Ser Ser His His Pro Phe Val Lys Asn Asp Lys 
        115                 120                 125             


Leu Thr Thr Tyr Asn Pro Leu Tyr Gly Gly Lys Asp Asn Pro Glu Lys 
    130                 135                 140                 


Pro Val Gly Arg Asp Met Leu Gly Leu Lys Asp Lys Leu Glu Glu Arg 
145                 150                 155                 160 


Tyr Phe Gly Cys Thr Phe Asn Asp Asn Leu His Ile Gln Ile Ile Tyr 
                165                 170                 175     


Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val His Ser Ala Asn Ile 
            180                 185                 190         


Thr Thr Ala Leu Asp His Met Val Asp Glu Asp Asp Glu Lys Tyr Leu 
        195                 200                 205             


Asn Ser Asp Tyr Ile Gly Tyr Met Asn Thr Ile Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Met Asp Pro Ser Lys Asn Ser Ser Leu Ser Pro Lys Asp Arg Lys 
225                 230                 235                 240 


Asn Ile Asp Asn Ser Arg Ala Lys Phe Glu Lys Leu Leu Ser Thr Lys 
                245                 250                 255     


Arg Leu Gly Tyr Phe Gly Phe Asp Tyr Asp Ala Asn Gly Lys Asp Lys 
            260                 265                 270         


Lys Lys Asn Glu Glu Ile Lys Lys Arg Leu Tyr His Leu Thr Ala Phe 
        275                 280                 285             


Ala Gly Gln Leu Arg Gln Trp Ser Phe His Ser Ala Gly Asn Tyr Pro 
    290                 295                 300                 


Arg Thr Trp Leu Tyr Lys Leu Asp Ser Leu Asp Lys Glu Tyr Leu Asp 
305                 310                 315                 320 


Thr Leu Asp His Tyr Phe Asp Lys Arg Phe Asn Asp Ile Asn Asp Asp 
                325                 330                 335     


Phe Val Thr Lys Asn Ala Thr Asn Leu Tyr Ile Leu Lys Glu Val Phe 
            340                 345                 350         


Pro Glu Ala Asn Phe Lys Asp Ile Ala Asp Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Ile Lys Ser His Lys Asn Met Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Glu Cys Asp Gly Ala Asp Arg Ile Lys Glu Gln Asp 
385                 390                 395                 400 


Met Asp Ser Val Arg Ser Lys Leu Tyr Lys Leu Ile Asp Phe Cys Ile 
                405                 410                 415     


Phe Lys Tyr Tyr His Glu Phe Pro Glu Leu Ser Glu Lys Asn Val Asp 
            420                 425                 430         


Ile Leu Arg Ala Ala Val Ser Asp Thr Lys Lys Asp Asn Leu Tyr Ser 
        435                 440                 445             


Asp Glu Ala Ala Arg Leu Trp Ser Ile Phe Lys Glu Lys Phe Leu Gly 
    450                 455                 460                 


Phe Cys Asp Lys Ile Val Val Trp Val Thr Gly Glu His Glu Lys Asp 
465                 470                 475                 480 


Ile Thr Ser Val Ile Asp Lys Asp Ala Tyr Arg Asn Arg Ser Asn Val 
                485                 490                 495     


Ser Tyr Phe Ser Lys Leu Met Tyr Ala Met Cys Phe Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn 
        515                 520                 525             


Ile Ala Asn Gln Ile Lys Thr Ala Lys Glu Leu Gly Ile Asn Thr Ala 
    530                 535                 540                 


Phe Val Lys Asn Tyr Asp Phe Phe Asn His Ser Glu Lys Tyr Val Asp 
545                 550                 555                 560 


Glu Leu Asn Ile Val Lys Asn Ile Ala Arg Met Lys Lys Pro Ser Ser 
                565                 570                 575     


Asn Ala Lys Lys Ala Met Tyr His Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Pro Glu Asp Met Asp Glu Lys Ala Leu Asp Glu Glu Leu Asp Leu Ile 
        595                 600                 605             


Leu Glu Lys Lys Thr Asp Pro Val Thr Gly Lys Pro Leu Lys Gly Lys 
    610                 615                 620                 


Asn Pro Leu Arg Asn Phe Ile Ala Asn Asn Val Ile Glu Asn Ser Arg 
625                 630                 635                 640 


Phe Ile Tyr Leu Ile Lys Phe Cys Asn Pro Glu Asn Val Arg Lys Ile 
                645                 650                 655     


Val Asn Asn Thr Lys Val Thr Glu Phe Val Leu Lys Arg Ile Pro Asp 
            660                 665                 670         


Ala Gln Ile Glu Arg Tyr Tyr Lys Ser Cys Thr Asp Ser Glu Met Asn 
        675                 680                 685             


Pro Pro Thr Glu Lys Lys Ile Thr Glu Leu Ala Gly Lys Leu Lys Asp 
    690                 695                 700                 


Met Asn Phe Gly Asn Phe Arg Asn Val Arg Gln Ser Ala Lys Glu Asn 
705                 710                 715                 720 


Met Glu Lys Glu Arg Phe Lys Ala Val Ile Gly Leu Tyr Leu Thr Val 
                725                 730                 735     


Val Tyr Arg Val Val Lys Asn Leu Val Asp Val Asn Ser Arg Tyr Ile 
            740                 745                 750         


Met Ala Phe His Ser Leu Glu Arg Asp Ser Gln Leu Tyr Asn Val Ser 
        755                 760                 765             


Val Asp Asn Asp Tyr Leu Ala Leu Thr Asp Thr Leu Val Lys Glu Gly 
    770                 775                 780                 


Asp Asn Ser Arg Ser Arg Tyr Leu Ala Gly Asn Lys Arg Leu Arg Asp 
785                 790                 795                 800 


Cys Val Lys Gln Asp Ile Asp Asn Ala Lys Lys Trp Phe Val Ser Asp 
                805                 810                 815     


Lys Tyr Asn Ser Ile Thr Lys Tyr Arg Asn Asn Val Ala His Leu Thr 
            820                 825                 830         


Ala Val Arg Asn Cys Ala Glu Phe Ile Gly Asp Ile Thr Lys Ile Asp 
        835                 840                 845             


Ser Tyr Phe Ala Leu Tyr His Tyr Leu Ile Gln Arg Gln Leu Ala Lys 
    850                 855                 860                 


Gly Leu Asp His Glu Arg Ser Gly Phe Asp Arg Asn Tyr Pro Gln Tyr 
865                 870                 875                 880 


Ala Pro Leu Phe Lys Trp His Thr Tyr Val Lys Asp Val Val Lys Ala 
                885                 890                 895     


Leu Asn Ala Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Asp Ala Leu Phe Asp Arg Asn Glu Ile Lys Lys Asn Asp Gly Glu 
        915                 920                 925             


Lys Lys Ser Asp Asp 
    930             


<210>  63
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig7093000170

<400>  63

Arg Gln Leu Ala Val Gly Leu Asp Pro Lys Arg Ser Gly Phe Glu Arg 
1               5                   10                  15      


Asn Tyr Pro Tyr Phe Ala Lys Leu Phe Glu Trp His Thr Tyr Val Lys 
            20                  25                  30          


Asp Met Val Lys Ala Leu Asn Ala Pro Phe Gly Tyr Asn Ile Pro Arg 
        35                  40                  45              


Phe Lys Asn Leu Ser Ile Asp Asp Leu Phe Asp Met Asn Glu Glu Arg 
    50                  55                  60                  


Val Lys Asp Ala Lys Ala 
65                  70  


<210>  64
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig11113000384

<400>  64

Ala Ser Glu Asn Glu Arg Lys Ala Lys Gln Gln Ala Gly Gln Pro Ala 
1               5                   10                  15      


Ala Lys Gly Asn Gly Glu Glu Lys Gln Lys Pro Ile Leu Lys Leu Asn 
            20                  25                  30          


Pro Val Arg Glu Arg Lys Leu Ser Thr Thr Leu Lys Ser Arg Ala Lys 
        35                  40                  45              


Ala Ala Gly Leu Lys Ser Thr Phe Val Ile Asn Asp Lys Glu Leu Leu 
    50                  55                  60                  


Met Thr Ala Phe Gly Arg Gly Asn Asp Ala Ile Pro Glu Lys Arg Ile 
65                  70                  75                  80  


Leu Gly Ala Gln Val Glu Thr Leu Ser Glu Lys 
                85                  90      


<210>  65
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig6403000259

<400>  65

Asn Lys Val Lys Glu Phe Glu Leu Asp Ala Ser Val Lys Tyr Arg Leu 
1               5                   10                  15      


Ser Lys Val Val Glu Ser Val Arg Leu Lys Asp Lys Ala Thr Tyr Phe 
            20                  25                  30          


Thr Lys Leu Ile Tyr Leu Thr Thr Leu Phe Leu Asp Gly Lys Glu Ile 
        35                  40                  45              


Asn Asp Leu Leu Thr Thr Leu Ile His Gln Phe Glu Asn Ile Ala Ser 
    50                  55                  60                  


Phe Ile Asp Val Met Lys Asp Arg Gly Ile Ala Asp Gly Phe Ser Gly 
65                  70                  75                  80  


Glu Tyr Lys Phe Phe Glu Ser Ser Lys Gln Val Ala Phe Glu Leu Arg 
                85                  90                  95      


Asn Val Asn Ser Phe Ala Arg Met Thr Lys Ala Ser Lys Asp Asp Asp 
            100                 105                 110         


Asn Ala Lys Gln Ile Met Phe 
        115                 


<210>  66
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig6193000124

<400>  66

Ala Glu Asp Tyr Tyr Asp Phe Leu Phe Lys Lys Thr Tyr Lys Tyr Leu 
1               5                   10                  15      


Gly Phe Ser Ile Lys Thr Leu Arg Glu Glu Phe Leu Thr Ile Lys Asp 
            20                  25                  30          


Ala Glu Lys Leu Lys Asp Lys Lys Tyr Asp Ser Val Arg Ser Lys Leu 
        35                  40                  45              


Tyr Lys Val Ile Asp Phe Leu Ile Phe Asp Leu Tyr Gln Asn Arg Glu 
    50                  55                  60                  


Cys Leu Arg Ile Asn Glu Leu Val Gln Arg Leu Arg Leu Ser Thr Asp 
65                  70                  75                  80  


Glu Leu Thr Lys Ala Lys Ile Tyr Ala Asp Glu Ala His Phe Val Tyr 
                85                  90                  95      


Lys Lys Leu Trp Asp Ile Ile Asp Thr Glu Ile Val Pro Gln Leu Asp 
            100                 105                 110         


Gln Lys Gly Ile Lys Ala Leu Glu Glu Ala Tyr 
        115                 120             


<210>  67
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig721000619

<400>  67

Lys Glu Gly Ser Thr Met Ala Lys Asn Glu Lys Lys Lys Ser Thr Ala 
1               5                   10                  15      


Lys Ala Leu Gly Leu Lys Ser Ser Phe Val Val Asn Asn Asp Ile Tyr 
            20                  25                  30          


Met Thr Ser Phe Gly Lys Gly Asn Lys Ala Val Leu Glu Lys Lys Ile 
        35                  40                  45              


Thr Glu Asn Thr Ile Glu Asn Lys Ser Asp Thr Thr Tyr Phe Asp Val 
    50                  55                  60                  


Ile Asn Arg Asp Pro Lys Gly Phe Thr Leu Glu Gly Arg Arg Ile Ala 
65                  70                  75                  80  


Asp Met Thr Ala Phe Ser Asn Asp Pro Lys Tyr His Val Asn Val Val 
                85                  90                  95      


Asn Gly Lys Phe Leu Glu Asp Gln Leu Gly Ala Arg Ser Glu Leu Glu 
            100                 105                 110         


Lys Lys Val Phe Gly Arg Thr Phe Asp Asp Asn Val His Ile Gln Leu 
        115                 120                 125             


Ile His Asn Ile Leu Asp Ile Glu Lys Ile Met Ala Gln Tyr Val Ser 
    130                 135                 140                 


Asp Ile Val Tyr Leu Leu His Asn Thr Ile Lys Arg Asp Met Asn Asp 
145                 150                 155                 160 


Asp Ile Met Gly Tyr Ile Ser Ile Arg Asn Ser Phe Asp Asp Phe Cys 
                165                 170                 175     


His Pro Glu Arg Ile Pro Asp Arg Lys Ala Lys Asp Asn Leu Gln Lys 
            180                 185                 190         


Gln His Asp Ile Phe Phe Asp Glu Ile Leu Lys Cys Gly Arg Leu Ala 
        195                 200                 205             


Tyr Phe Gly Asn Ala Phe Phe Glu Asp Gly Ser Asp Asn Lys Glu Ile 
    210                 215                 220                 


Ala Lys Leu Lys Arg Tyr Lys Glu Ile Tyr His Ile Ile Ala Leu Met 
225                 230                 235                 240 


Gly Ser Leu Arg Gln Ser Tyr Phe His Gly Glu Asn Ser Asp Lys Asn 
                245                 250                 255     


Phe Gln Gly Pro Thr Trp Ala Tyr Thr Leu Glu Ser Asn Leu Thr Gly 
            260                 265                 270         


Lys Tyr Lys Glu Phe Lys Asp Thr Leu Asp Lys Thr Phe Asp Glu Arg 
        275                 280                 285             


Tyr Glu Met Ile Ser Lys Asp Phe Gly Ser Thr Asn Met Val Asn Leu 
    290                 295                 300                 


Gln Ile Leu Glu Glu Leu Leu Lys Met Leu Tyr Gly Asn Val Ser Pro 
305                 310                 315                 320 


<210>  68
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig1666000270

<400>  68

Lys Glu Leu Lys Phe Arg Ile Asn Gly Lys Phe Ile Lys Asn Tyr His 
1               5                   10                  15      


Asp Arg Tyr Asp Glu Asp Ser Ala Asn Arg Arg Trp Lys Val Val Thr 
            20                  25                  30          


Lys Gln Asn Asp Val Asn Leu Phe Cys Lys Leu Ile Tyr Met Met Thr 
        35                  40                  45              


Leu Leu Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Val 
    50                  55                  60                  


Asn Lys Phe Asp Asn Ile Ala Ser Phe Ile Asp Val Met Glu Asp Met 
65                  70                  75                  80  


Gly Ile Glu His Arg Phe Ile Gly Gly Tyr Asp Met Phe Ala Asp Ser 
                85                  90                  95      


Lys Lys Ile Cys Val Asp Leu Gln Met Ile Asn Ser Phe Ala Arg Met 
            100                 105                 110         


Gln Val Thr Met Lys Ser Ala Lys Lys Met Leu Tyr Arg Asp Ala Leu 
        115                 120                 125             


Val Ile Leu Gly Met Asp Gln Ser Glu Glu Glu Ile Glu Arg Phe Met 
    130                 135                 140                 


Leu Glu Asn Asn Ile Ile Lys Asp Asn Asn Glu Asp Lys Ser Glu Lys 
145                 150                 155                 160 


Lys Gln His Asp Phe Arg Asn Phe Leu Ile Asn Ser Val Ile Asn Ser 
                165                 170                 175     


Ser Arg Phe Arg Tyr Met Val Arg Tyr Ser Ser Ala Asp Gly Leu Arg 
            180                 185                 190         


Lys Leu Lys Lys Ser Arg Lys Leu Ile Gly Phe Val Leu Asn Ser Leu 
        195                 200                 205             


Pro Glu Thr Leu Ile Asp Arg Tyr Tyr His Ser Cys 
    210                 215                 220 


<210>  69
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig2002000411

<400>  69

Glu Lys Gln Asn Lys Ala Lys Tyr Gln Ala Ile Ile Ser Leu Tyr Leu 
1               5                   10                  15      


Met Val Met Tyr Gln Ile Val Lys Asn Met Ile Tyr Val Asn Ser Arg 
            20                  25                  30          


Tyr Val Ile Ala Phe His Cys Leu Glu Arg Asp Ser Asn Gln Leu Leu 
        35                  40                  45              


Gly Arg Phe Asn Ser Arg Asp Ala Ser Met Tyr Asn Lys Leu Thr Gln 
    50                  55                  60                  


Lys Phe Ile Thr Asp Lys Tyr Leu Asn Asp Gly Ala Gln Gly Cys Ser 
65                  70                  75                  80  


Lys Lys Val Gly Asn Tyr Leu Ser His Asn Ile Thr Cys Cys Ser Asp 
                85                  90                  95      


Glu Leu Arg Lys Glu Tyr Arg Asn Gln Val Asp His Phe Ala Val Val 
            100                 105                 110         


Arg Met Ile Gly Lys Tyr Ala Ala Asp Ile Gly Lys Phe Ser Thr Trp 
        115                 120                 125             


Phe Glu Leu Tyr His Tyr Val Met Gln Arg Ile Ile Phe Asp Lys Arg 
    130                 135                 140                 


Asn Pro Leu Ser Glu Thr Glu Arg Thr Tyr Lys Gln Leu Ile Ala Lys 
145                 150                 155                 160 


His His Thr Tyr Cys Lys Asp Leu Val Lys Ala Leu Asn Thr Pro Phe 
                165                 170                 175     


Gly Tyr Asn Leu Ala Arg Tyr Lys Asn Leu Ser Ile Gly Glu Leu Phe 
            180                 185                 190         


Asp Arg Asn Asn Tyr Asn Ala Lys Thr Lys Glu Thr 
        195                 200                 


<210>  70
<211>  944
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ruminococcus_albus

<400>  70

Met Ala Lys Lys Ser Lys Gly Met Ser Leu Arg Glu Lys Arg Glu Leu 
1               5                   10                  15      


Glu Lys Gln Lys Arg Ile Gln Lys Ala Ala Val Asn Ser Val Asn Asp 
            20                  25                  30          


Thr Pro Glu Lys Thr Glu Glu Ala Asn Val Val Ser Val Asn Val Arg 
        35                  40                  45              


Thr Ser Ala Glu Asn Lys His Ser Lys Lys Ser Ala Ala Lys Ala Leu 
    50                  55                  60                  


Gly Leu Lys Ser Gly Leu Val Ile Gly Asp Glu Leu Tyr Leu Thr Ser 
65                  70                  75                  80  


Phe Gly Arg Gly Asn Glu Ala Lys Leu Glu Lys Lys Ile Ser Gly Asp 
                85                  90                  95      


Thr Val Glu Lys Leu Gly Ile Gly Ala Phe Glu Val Ala Glu Arg Asp 
            100                 105                 110         


Glu Ser Thr Leu Thr Leu Glu Ser Gly Arg Ile Lys Asp Lys Thr Ala 
        115                 120                 125             


Arg Pro Lys Asp Pro Arg His Ile Thr Val Asp Thr Gln Gly Lys Phe 
    130                 135                 140                 


Lys Glu Asp Met Leu Gly Ile Arg Ser Val Leu Glu Lys Lys Ile Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Val Gln Leu Ala Tyr Asn Ile 
                165                 170                 175     


Leu Asp Val Glu Lys Ile Met Ala Gln Tyr Val Ser Asp Ile Val Tyr 
            180                 185                 190         


Met Leu His Asn Thr Asp Lys Thr Glu Arg Asn Asp Asn Leu Met Gly 
        195                 200                 205             


Tyr Met Ser Ile Arg Asn Thr Tyr Lys Thr Phe Cys Asp Thr Ser Asn 
    210                 215                 220                 


Leu Pro Asp Asp Thr Lys Gln Lys Val Glu Asn Gln Lys Arg Glu Phe 
225                 230                 235                 240 


Asp Lys Ile Ile Lys Ser Gly Arg Leu Gly Tyr Phe Gly Glu Ala Phe 
                245                 250                 255     


Met Val Asn Ser Gly Asn Ser Thr Lys Leu Arg Pro Glu Lys Glu Ile 
            260                 265                 270         


Tyr His Ile Phe Ala Leu Met Ala Ser Leu Arg Gln Ser Tyr Phe His 
        275                 280                 285             


Gly Tyr Val Lys Asp Thr Asp Tyr Gln Gly Thr Thr Trp Ala Tyr Thr 
    290                 295                 300                 


Leu Glu Asp Lys Leu Lys Gly Pro Ser His Glu Phe Arg Glu Thr Ile 
305                 310                 315                 320 


Asp Lys Ile Phe Asp Glu Gly Phe Ser Lys Ile Ser Lys Asp Phe Gly 
                325                 330                 335     


Lys Met Asn Lys Val Asn Leu Gln Ile Leu Glu Gln Met Ile Gly Glu 
            340                 345                 350         


Leu Tyr Gly Ser Ile Glu Arg Gln Asn Leu Thr Cys Asp Tyr Tyr Asp 
        355                 360                 365             


Phe Ile Gln Leu Lys Lys His Lys Tyr Leu Gly Phe Ser Ile Lys Arg 
    370                 375                 380                 


Leu Arg Glu Thr Met Leu Glu Thr Thr Pro Ala Glu Cys Tyr Lys Ala 
385                 390                 395                 400 


Glu Cys Tyr Asn Ser Glu Arg Gln Lys Leu Tyr Lys Leu Ile Asp Phe 
                405                 410                 415     


Leu Ile Tyr Asp Leu Tyr Tyr Asn Arg Lys Pro Ala Arg Ile Glu Glu 
            420                 425                 430         


Ile Val Asp Lys Leu Arg Glu Ser Val Asn Asp Glu Glu Lys Glu Ser 
        435                 440                 445             


Ile Tyr Ser Val Glu Ala Lys Tyr Val Tyr Glu Ser Leu Ser Lys Val 
    450                 455                 460                 


Leu Asp Lys Ser Leu Lys Asn Ser Val Ser Gly Glu Thr Ile Lys Asp 
465                 470                 475                 480 


Leu Gln Lys Arg Tyr Asp Asp Glu Thr Ala Asn Arg Ile Trp Asp Ile 
                485                 490                 495     


Ser Gln His Ser Ile Ser Gly Asn Val Asn Cys Phe Cys Lys Leu Ile 
            500                 505                 510         


Tyr Ile Met Thr Leu Met Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu 
        515                 520                 525             


Thr Thr Leu Val Asn Lys Phe Asp Asn Ile Ala Ser Phe Ile Asp Val 
    530                 535                 540                 


Met Asp Glu Leu Gly Leu Glu His Ser Phe Thr Asp Asn Tyr Lys Met 
545                 550                 555                 560 


Phe Ala Asp Ser Lys Ala Ile Cys Leu Asp Leu Gln Phe Ile Asn Ser 
                565                 570                 575     


Phe Ala Arg Met Ser Lys Ile Asp Asp Glu Lys Ser Lys Arg Gln Leu 
            580                 585                 590         


Phe Arg Asp Ala Leu Val Ile Leu Asp Ile Gly Asn Lys Asp Glu Thr 
        595                 600                 605             


Trp Ile Asn Asn Tyr Leu Asp Ser Asp Ile Phe Lys Leu Asp Lys Glu 
    610                 615                 620                 


Gly Asn Lys Leu Lys Gly Ala Arg His Asp Phe Arg Asn Phe Ile Ala 
625                 630                 635                 640 


Asn Asn Val Ile Lys Ser Ser Arg Phe Lys Tyr Leu Val Lys Tyr Ser 
                645                 650                 655     


Ser Ala Asp Gly Met Ile Lys Leu Lys Thr Asn Glu Lys Leu Ile Gly 
            660                 665                 670         


Phe Val Leu Asp Lys Leu Pro Glu Thr Gln Ile Asp Arg Tyr Tyr Glu 
        675                 680                 685             


Ser Cys Gly Leu Asp Asn Ala Val Val Asp Lys Lys Val Arg Ile Glu 
    690                 695                 700                 


Lys Leu Ser Gly Leu Ile Arg Asp Met Lys Phe Asp Asp Phe Ser Gly 
705                 710                 715                 720 


Val Lys Thr Ser Asn Lys Ala Gly Asp Asn Asp Lys Gln Asp Lys Ala 
                725                 730                 735     


Lys Tyr Gln Ala Ile Ile Ser Leu Tyr Leu Met Val Leu Tyr Gln Ile 
            740                 745                 750         


Val Lys Asn Met Ile Tyr Val Asn Ser Arg Tyr Val Ile Ala Phe His 
        755                 760                 765             


Cys Leu Glu Arg Asp Phe Gly Met Tyr Gly Lys Asp Phe Gly Lys Tyr 
    770                 775                 780                 


Tyr Gln Gly Cys Arg Lys Leu Thr Asp His Phe Ile Glu Glu Lys Tyr 
785                 790                 795                 800 


Met Lys Glu Gly Lys Leu Gly Cys Asn Lys Lys Val Gly Arg Tyr Leu 
                805                 810                 815     


Lys Asn Asn Ile Ser Cys Cys Thr Asp Gly Leu Ile Asn Thr Tyr Arg 
            820                 825                 830         


Asn Gln Val Asp His Phe Ala Val Val Arg Lys Ile Gly Asn Tyr Ala 
        835                 840                 845             


Ala Tyr Ile Lys Ser Ile Gly Ser Trp Phe Glu Leu Tyr His Tyr Val 
    850                 855                 860                 


Ile Gln Arg Ile Val Phe Asp Glu Tyr Arg Phe Ala Leu Asn Asn Thr 
865                 870                 875                 880 


Glu Ser Asn Tyr Lys Asn Ser Ile Ile Lys His His Thr Tyr Cys Lys 
                885                 890                 895     


Asp Met Val Lys Ala Leu Asn Thr Pro Phe Gly Tyr Asp Leu Pro Arg 
            900                 905                 910         


Tyr Lys Asn Leu Ser Ile Gly Asp Leu Phe Asp Arg Asn Asn Tyr Leu 
        915                 920                 925             


Asn Lys Thr Lys Glu Ser Ile Asp Ala Asn Ser Ser Ile Asp Ser Gln 
    930                 935                 940                 


<210>  71
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig13552000311

<400>  71

Leu Ile Asp Phe Leu Ile Tyr Asp Leu Tyr Tyr Asn Arg Lys Pro Ala 
1               5                   10                  15      


Arg Ile Glu Glu Ile Val Asp Lys Leu Arg Glu Ser Val Asn Asp Glu 
            20                  25                  30          


Glu Lys Glu Ser Ile Tyr Ser Ala Glu Thr Lys Tyr Val Tyr Glu Ala 
        35                  40                  45              


Leu Gly Lys Val Leu Val Arg Ser Leu Lys Lys Tyr Leu Asn Gly Ala 
    50                  55                  60                  


Thr Ile Arg Asp Leu Lys Asn Arg Tyr Asp Ala Lys Thr Ala Asn Arg 
65                  70                  75                  80  


Ile Trp Asp Ile Ser Glu His Ser Lys Ser Gly His Val Asn Cys Phe 
                85                  90                  95      


Cys Lys Leu Ile Tyr Met Met Thr Leu Met Leu Asp Gly Lys Glu Ile 
            100                 105                 110         


Asn Asp Leu Leu Thr Thr Leu Val Asn Lys Phe Asp Asn Ile Ala Ser 
        115                 120                 125             


Phe Ile Asp Val Met Asp Glu Leu Gly Leu Glu His Ser Phe Thr Asp 
    130                 135                 140                 


Asn Tyr Lys Met Phe Ala Asp Ser Lys Ala Ile Cys Leu Asp Leu Gln 
145                 150                 155                 160 


Phe Ile Asn Ser Phe Ala Arg Met Ser Lys Ile Asp Asp Glu Lys Ser 
                165                 170                 175     


Lys Arg Gln Leu Phe Arg Asp Ala Leu Val Val Leu Asp Ile Gly Asp 
            180                 185                 190         


Lys Asn Glu Asp Trp Ile Glu Lys Tyr Leu Thr Ser Asp Ile Phe Lys 
        195                 200                 205             


Arg Asp Glu Asn Gly Asn Lys Ile Asp Gly Glu Lys Arg Asp Phe Arg 
    210                 215                 220                 


Asn Phe Ile Ala Asn Asn Val Ile Lys Ser Ala Arg Phe Lys Tyr Leu 
225                 230                 235                 240 


Val Lys Tyr Ser Ser Ala Asp Gly Met Ile Lys Leu Lys Lys Asn Glu 
                245                 250                 255     


Lys Leu Ile Ser Phe Val Leu Glu Gln Leu Pro Glu Thr Gln Ile Asp 
            260                 265                 270         


Arg Tyr Tyr Glu Ser Cys Gly Leu Asp Cys Ala Val Ala Asp Arg Lys 
        275                 280                 285             


Val Arg Ile Glu Lys Leu Thr Gly Leu Ile Arg Asp Met Arg Phe Asp 
    290                 295                 300                 


Asn Phe Arg Gly Val Asn Tyr Ser Asn Asp Ala Cys Lys Lys Asp Lys 
305                 310                 315                 320 


Gln Ala Lys Ala Lys Tyr Gln Ala Ile Ile Ser Leu Tyr Leu Met Val 
                325                 330                 335     


Leu Tyr Gln Ile Val Lys Asn Met Ile Tyr Val Asn Ser Arg Tyr Val 
            340                 345                 350         


Ile Ala Phe His Cys Leu Glu Arg Asp Leu Leu Phe Phe Asn Ile Glu 
        355                 360                 365             


Leu Asp Asn Ser Tyr Gln Tyr Ser Asn Cys Asn Glu Leu Thr Glu Lys 
    370                 375                 380                 


Phe Ile Lys Asp Lys Tyr Met Lys Glu Gly Ala Leu Gly Phe Asn Met 
385                 390                 395                 400 


Lys Ala Gly Arg Tyr Leu Thr Lys Asn Ile Gly Asn Cys Ser Asn Glu 
                405                 410                 415     


Leu Arg Lys Ile Tyr Arg Asn Gln Val Asp His Phe Ala Val Val Arg 
            420                 425                 430         


Lys Ile Gly Asn Tyr Ala Ala Asp Ile Ala Ser Val Gly Ser Trp Phe 
        435                 440                 445             


Glu 
    


<210>  72
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig10037000527

<400>  72

Tyr Met Asp Gln Asn Phe Ala Asn Ser Asp Ala Trp Ala Ile His Val 
1               5                   10                  15      


Tyr Arg Asn Lys Ile Gln His Leu Asp Ala Val Arg His Ala Asp Met 
            20                  25                  30          


Tyr Ile Gly Asp Ile Arg Glu Phe His Ser Trp Phe Glu Leu Tyr His 
        35                  40                  45              


Tyr Ile Ile Gln Arg Arg Ile Ile Asp Gln Tyr Ala Tyr Glu Ser Thr 
    50                  55                  60                  


Pro Gly Ser Ser Arg Asp Gly Ser Ala Ile Ile Asp Glu Glu Arg Leu 
65                  70                  75                  80  


Asn Pro Ala Thr Arg Arg Tyr Phe Arg Leu Ile Thr Thr Tyr Lys Thr 
                85                  90                  95      


<210>  73
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig238000329

<400>  73

Arg Tyr Asp Lys Asp Arg Ser Lys Ile Tyr Thr Met Met Asp Phe Val 
1               5                   10                  15      


Ile Tyr Arg Tyr Tyr Ile Asp Asn Asn Asn Asp Ser Ile Asp Phe Ile 
            20                  25                  30          


Asn Lys Leu Arg Ser Ser Ile Asp Glu Lys Ser Lys Glu Lys Leu Tyr 
        35                  40                  45              


Asn Glu Glu Ala Asn Arg Leu Trp Asn Lys Leu Lys Glu Tyr Met Leu 
    50                  55                  60                  


Tyr Ile Lys Glu Phe Asn Gly Lys Leu Ala Ser Arg Thr Pro Asp Arg 
65                  70                  75                  80  


Asp Gly Asn Ile Ser Glu Phe Val Glu Ser Leu Pro Lys Ile His Arg 
                85                  90                  95      


Leu Leu Pro Arg Gly Gln Lys Ile Ser Asn Phe Ser Lys Leu Met Tyr 
            100                 105                 110         


Leu Leu Thr Met Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr 
        115                 120                 125             


Thr Leu Ile Asn Lys Phe Glu Asn Ile Gln Gly Phe Leu Asp Ile Met 
    130                 135                 140                 


Pro Glu Ile Asn Val Asn Ala Lys Phe Glu Pro Glu Tyr Val Phe Phe 
145                 150                 155                 160 


Asn Lys Ser His Glu Ile Ala Gly Glu Leu Lys Leu Ile Lys Gly Phe 
                165                 170                 175     


Ala Gln Met Gly Glu Pro Ala Ala Thr Leu Lys Leu Glu Met Thr Ala 
            180                 185                 190         


Asp Ala Ile Lys Ile Leu Gly Thr Glu Lys Glu Asp Ala Glu Leu Ile 
        195                 200                 205             


Lys Leu Ala Glu Ser Leu Phe Lys Asp Glu Asn Gly Lys Leu Leu Gly 
    210                 215                 220                 


Asn Lys Gln His Gly Met Arg Asn Phe Ile Gly Asn Asn Val Ile Lys 
225                 230                 235                 240 


Ser Lys Arg Phe His Tyr Leu Ile Arg Tyr Gly Asp Pro Ala His Leu 
                245                 250                 255     


His Lys Ile Ala Thr Asn Lys Asn Val Val Arg Phe Val Leu Gly Arg 
            260                 265                 270         


Ile Ala Asp Met Gln Lys Lys Gln Gly Gln Lys Gly Lys Asn Gln Ile 
        275                 280                 285             


Asp Arg Tyr Tyr Glu Val Cys Val Gly Asn Lys Asp Ile Lys Lys Thr 
    290                 295                 300                 


Ile Glu Glu Lys Ile Asp Ala Leu Thr Asp Ile Ile Val Asn Met Asn 
305                 310                 315                 320 


Tyr Asp Gln Phe Glu Lys Lys Lys Ala Val Ile Glu Asn Gln Asn Arg 
                325                 330                 335     


Gly Lys Thr Phe Glu Glu Lys Asn Lys Tyr Lys Arg Asp Asn Ala Glu 
            340                 345                 350         


Arg Glu Lys Phe Lys Lys Ile Ile Ser Leu Tyr Leu Thr Val Ile Tyr 
        355                 360                 365             


His Ile Leu Lys Asn Ile Val Asn Val Asn Ser Arg Tyr Ile Leu Gly 
    370                 375                 380                 


Phe His Cys Leu Glu Arg Asp Lys Gln Leu Tyr Ile Glu Lys Tyr Asn 
385                 390                 395                 400 


Lys Asp Lys Leu Asp Gly Phe Val Ala Leu Thr Lys Phe Cys Leu Gly 
                405                 410                 415     


Asp Glu Glu Arg Tyr Glu Asp Leu Lys Ala Lys Ala Gln Ala Ser Ile 
            420                 425                 430         


Gln Ala Leu Glu Thr Ala Asn Pro Lys Leu Tyr Ala Lys Tyr Met Asn 
        435                 440                 445             


Tyr Ser Asp Glu Glu Lys Lys Glu Glu Phe Lys Lys Gln Leu Asn Arg 
    450                 455                 460                 


Glu Arg Val Lys Asn Ala Arg Asn Ala Tyr Leu Lys Asn Ile Lys Asn 
465                 470                 475                 480 


Tyr Ile Met Ile Arg Leu Gln Leu Arg Asp Gln Thr Asp Ser Ser Gly 
                485                 490                 495     


Tyr Leu Cys Gly Glu Phe Arg Asp Lys Val Ala His Leu Glu Val Ala 
            500                 505                 510         


Arg His Ala His Glu Tyr Ile 
        515                 


<210>  74
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig2643000492

<400>  74

Asn Gly Glu Ile Val Ser Leu Ala Glu Lys Glu Ala Phe Ser Ala Lys 
1               5                   10                  15      


Ile Ala Asp Lys Asn Ile Gly Cys Lys Ile Glu Asn Lys Gln Phe Arg 
            20                  25                  30          


His Pro Lys Gly Tyr Asp Val Ile Ala Asp Asn Pro Ile Tyr Lys Gly 
        35                  40                  45              


Ser Pro Arg Gln Asp Met Leu Gly Leu Lys Glu Thr Leu Glu Lys Arg 
    50                  55                  60                  


Tyr Phe Ser Pro Ser Asp Ser Ile Asp Asn Val Arg Val Gln Val Ala 
65                  70                  75                  80  


His Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn 
                85                  90                  95      


Ala Val Tyr Ser Phe Asp Asn Ile Ala Gly Phe Gly Lys Asp Ile Ile 
            100                 105                 110         


Gly Asp Asp Phe Ser Pro Val Tyr Thr Tyr Asp Lys Phe Glu Lys Ser 
        115                 120                 125             


Asp Arg Tyr Glu Tyr Phe Lys Asn Leu Leu Asn Asn Ser Arg Leu Gly 
    130                 135                 140                 


Tyr Tyr Gly Gln Ala Phe Phe Glu Cys Asp Asp Ser Lys Glu Asn Lys 
145                 150                 155                 160 


Lys Lys Lys Asp Ala Ile Lys Cys Tyr Asn Ile Ile Ala Leu Leu Ser 
                165                 170                 175     


Gly Leu Arg His Trp 
            180     


<210>  75
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig874000057

<400>  75

Met Ser Lys Asn Lys Glu Ser Tyr Ala Lys Gly Met Gly Leu Lys Ser 
1               5                   10                  15      


Ala Leu Val Ser Gly Ser Lys Val Tyr Met Thr Ser Phe Glu Gly Gly 
            20                  25                  30          


Asn Asp Ala Lys Leu Glu Lys Val Val Glu Asn Ser Glu Ile Val Ser 
        35                  40                  45              


Leu Ala Glu Lys Glu Ser Phe Ser Ala Glu Ile Phe Lys Lys Asn Ile 
    50                  55                  60                  


Gly Cys Lys Ile Glu Asn Lys Lys Phe Lys His Pro Lys Arg Tyr Asp 
65                  70                  75                  80  


Val Ile Ala Asp Asn Pro Leu Tyr Lys Gly Ser Val Arg Gln Asp Met 
                85                  90                  95      


Leu Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Asn Ser Ala Asp 
            100                 105                 110         


Gly Thr Asp Asn Val Cys Ile Gln Val Ile His Asn Ile Leu Asp Ile 
        115                 120                 125             


Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Val Tyr Ser Phe Asp 
    130                 135                 140                 


Asn Ile Ala Gly Phe Gly Glu Asp Ile Ile Gly Met Gly Gly Phe Lys 
145                 150                 155                 160 


Pro Ile Tyr Thr Tyr Lys Gln Phe Lys Glu Pro Asp Lys Tyr Asn Lys 
                165                 170                 175     


Lys Phe Asp Asp Ile Leu Asn Asn Ser Arg Leu Gly Tyr Tyr Gly Lys 
            180                 185                 190         


Ala Phe Phe Glu Lys Asn Asp Leu Lys His Asn Pro Asn Lys Lys Lys 
        195                 200                 205             


Arg Asp Lys Asn Pro Tyr Ile Leu Lys Tyr Asp Asn Glu Cys Tyr Tyr 
    210                 215                 220                 


Ile Ile Ala Leu Leu Ser Gly Leu Arg His Trp Asn Ile His Ser His 
225                 230                 235                 240 


Ala Lys Asp Asp Leu Val Ser Tyr Arg Trp Leu Tyr Asn Leu Asp Ser 
                245                 250                 255     


Ile Leu Asn Arg Glu Tyr Ile Ser Thr Leu Asn Tyr Leu Tyr Asp Asp 
            260                 265                 270         


Ile Ala Asp Glu Leu Thr Glu Ser Phe Ser Lys Asn Ser Ser Ala Asn 
        275                 280                 285             


Val Asn Tyr Ile Ala Glu Thr Leu Asn Ile Asp Pro Ser Glu Phe Ala 
    290                 295                 300                 


Gln Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu Gln Lys Asn Met Gly 
305                 310                 315                 320 


Phe Asn Val Ser Lys Leu Arg Glu Ile Met Leu Asp Arg Lys Glu Leu 
                325                 330                 335     


Ser Asp Ile Arg Asp Asn His Arg Val Phe Asp Ser Ile Arg Ser Lys 
            340                 345                 350         


Leu Tyr Thr Met Met Asp Phe Val Ile Tyr Arg Tyr Tyr Ile Glu Glu 
        355                 360                 365             


Ala Ala Lys Thr Glu Ala Glu Asn Arg Asn Leu Pro Glu Asn Glu Lys 
    370                 375                 380                 


Lys Ile Ser Glu Lys Asp Phe Phe Val Ile Asn Leu Arg Gly Ser Phe 
385                 390                 395                 400 


Asp Glu Asn Gln Lys Glu Lys Leu Tyr Ile Glu Glu Ala Lys Arg Leu 
                405                 410                 415     


Trp Glu Lys Leu Lys Asp Ile Met Leu Lys Ile Lys Glu Phe Arg Gly 
            420                 425                 430         


Glu Lys Val Lys Glu Tyr Lys Lys 
        435                 440 


<210>  76
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig4781000489

<400>  76

Leu Asp Lys Gln Leu Asp Tyr Glu Tyr Ile Arg Thr Leu Asn Tyr Met 
1               5                   10                  15      


Phe Asn Asp Ile Ala Asp Glu Leu Thr Arg Thr Phe Ser Lys Asn Ser 
            20                  25                  30          


Ala Ala Asn Val Asn Tyr Ile Ala Glu Thr Leu Asn Ile Asp Pro Asn 
        35                  40                  45              


Lys Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu Gln Lys 
    50                  55                  60                  


Asn Leu Gly Phe Asn Leu Thr Lys Leu Arg Glu Ser Met Leu Asp Arg 
65                  70                  75                  80  


Arg Glu Leu Ser Asp Ile Arg Asp Asn His Asn Val Phe Asp Ser Ile 
                85                  90                  95      


Arg Pro Lys Leu Tyr Thr Met Met Asp Phe Val Ile Tyr Lys His Tyr 
            100                 105                 110         


Ile Asp Glu Ala Lys Lys Thr Glu Ala Glu Asn Lys Ser Leu Pro Asp 
        115                 120                 125             


Asp Arg Lys Asn Leu Ser Glu Lys Asp 
    130                 135         


<210>  77
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig12144000352

<400>  77

Arg Met Gly Glu Pro Val Ala Asn Thr Lys Arg Val Met Met Ile Asp 
1               5                   10                  15      


Ala Val Lys Ile Leu Gly Thr Asp Leu Ser Asp Asp Glu Leu Lys Glu 
            20                  25                  30          


Met Ala Asp Ser Phe Phe Lys Asp Ser Asp Gly Asn Leu Leu Lys Lys 
        35                  40                  45              


Gly Lys His Gly Met Arg Asn Phe Ile Thr Asn Asn Val Ile Lys Asn 
    50                  55                  60                  


Lys Arg Phe His Tyr Leu Ile Arg Tyr Gly Asp Pro Ala His Leu His 
65                  70                  75                  80  


Glu Ile Ala Lys Asn Glu Ala 
                85          


<210>  78
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig5590000448

<400>  78

Val His Asn Asn Glu Glu Lys Asp Leu Ile Lys Tyr Thr Trp Leu Tyr 
1               5                   10                  15      


Asn Leu Asp Lys Tyr Leu Asp Ala Glu Tyr Ile Thr Thr Leu Asn Tyr 
            20                  25                  30          


Met Tyr Asn Asp Ile Gly Asp Glu Leu Thr Asp Ser Phe Ser Lys Asn 
        35                  40                  45              


Ser Ala Ala Asn Ile Asn Tyr Ile Ala Glu Thr Leu Gly Ile Asp Pro 
    50                  55                  60                  


Lys Thr Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu Gln 
65                  70                  75                  80  


Lys Asn Leu Gly Phe Asn Leu Thr Lys Leu Arg Glu Val Met Leu Asp 
                85                  90                  95      


Arg Lys Asp Met Ser Glu Ile Arg Glu Asn His Asn Asp Phe Asp Ser 
            100                 105                 110         


Ile Arg Ala Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr Arg Tyr 
        115                 120                 125             


Tyr Ile Glu Glu Ala Ala Lys Val Asn Ala Ala Asn Lys Ser Leu Pro 
    130                 135                 140                 


Asp Asn Glu Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile Ser Leu 
145                 150                 155                 160 


Arg Gly Ser Phe Asn Glu Asp Gln Lys Asp Arg Leu Tyr Tyr Asp Glu 
                165                 170                 175     


Ala Gln Arg Leu Trp Ser Lys Val Gly Lys Leu Met Leu Lys Ile Lys 
            180                 185                 190         


Lys Phe Arg Gly Lys Asp Thr Arg Lys Tyr Lys Asn Met Gly Thr Pro 
        195                 200                 205             


Arg Ile Arg Arg Leu Ile Pro Glu Gly Arg Asp Ile Ser Thr Phe Ser 
    210                 215                 220                 


Lys Leu Met Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu Ile Asn 
225                 230                 235                 240 


Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln Ser Phe 
                245                 250                 255     


Leu Lys Val Met Pro Leu Ile Gly Val Asn Ala Lys Phe Ala Glu Glu 
            260                 265                 270         


Tyr Ser Phe Phe Asn Asn Ser Glu Lys Ile Ala Asp Glu Leu Arg Leu 
        275                 280                 285             


Ile Lys Ser Phe Ala Arg Met Gly Glu Pro Val Ala Asp Ala Arg Arg 
    290                 295                 300                 


Ala Met Tyr Ile Asp Ala Ile Arg Ile Leu Gly Thr Asp Leu Ser Asp 
305                 310                 315                 320 


Asp Glu Leu Lys Ala Leu Ala Asp Ser Phe Ser Leu Asp Glu Asn Gly 
                325                 330                 335     


Asn Lys Leu Gly Lys Gly Lys His Gly Met Arg Asn Phe Ile Ile Asn 
            340                 345                 350         


Asn Val Ile Thr Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr Gly Asn 
        355                 360                 365             


Pro Val His Leu His Glu Ile Ala Lys Asn Glu Ala Val Val Lys Phe 
    370                 375                 380                 


Val Leu Gly Arg Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln Asn Gly 
385                 390                 395                 400 


Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys 
                405                 410                 


<210>  79
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig9269000031

<400>  79

Leu Ser Glu Lys Asp Ile Phe Val Ile Ser Leu Arg Gly Ser Phe Asn 
1               5                   10                  15      


Glu Asp Gln Lys Asp Arg Leu Tyr Tyr Asp Glu Ala Gln Arg Leu Trp 
            20                  25                  30          


Ser Lys Leu Gly Lys Leu Met Leu Lys Ile Lys Glu Phe Lys Gly Lys 
        35                  40                  45              


Asp Thr Lys Lys Tyr Arg Asp Met Gly Lys Pro Arg Leu Arg Arg Ile 
    50                  55                  60                  


Leu Pro Glu Gly Arg Asp Ile Ser Thr Phe Ser Lys Leu Met Tyr Ala 
65                  70                  75                  80  


Leu Thr Met Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr 
                85                  90                  95      


Leu Ile Asn Lys Phe Asp Asn Ile Gln Ser Phe Leu Lys 
            100                 105                 


<210>  80
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig8537000520

<400>  80

Ser Ala Arg Leu Ala Asp Glu Leu Arg Ile Val Lys Ser Val Ser Arg 
1               5                   10                  15      


Met Glu Met Pro Met Pro Ala Ala Lys Thr Leu Met Phe Glu Asp Ala 
            20                  25                  30          


Leu Lys Leu Phe Trp Ile Asp Ser Pro Glu Glu Ala Lys Lys Ile Ile 
        35                  40                  45              


Ser Gly Asp Asn Lys Lys Ile Arg Asn Phe Ile Ala Asn Asn Val Val 
    50                  55                  60                  


Glu Ser Ser Trp Phe Asn Tyr Ile Val Arg Tyr Thr Asp Leu Lys Asn 
65                  70                  75                  80  


Ala Arg Asp Phe Ile Arg Cys Arg Pro Ile Val Glu Phe Val Leu Asn 
                85                  90                  95      


Lys Val Pro Glu Thr Gln Ile Asp Arg 
            100                 105 


<210>  81
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig1845000130

<400>  81

Ser Ser Leu Asn Glu Val Glu Lys Asp Ala Ile Tyr Ala Glu Glu Ala 
1               5                   10                  15      


Lys Gln Ala Trp Val Asn Ile Arg Asp Leu Val Ile Arg His Ile Leu 
            20                  25                  30          


Pro Met Met Lys Gly Asp Tyr Ile Ala Gln Ile Ser Val Glu Asp Glu 
        35                  40                  45              


Lys Ile Asp Gln Ser Ile Leu Glu Asp Val Phe Ile Ser Lys Ile Thr 
    50                  55                  60                  


Pro Ser Ala Leu Ala Glu Phe Ile Tyr Ile Val Thr Leu Phe Ile Asp 
65                  70                  75                  80  


Gly Lys Glu Ile Asn Asp Leu Leu Thr Gln Met Ile His Lys Phe Asp 
                85                  90                  95      


Ser Ile Ala Ala Phe Gln Glu Val Met Arg Gln Arg Cys Met Val Thr 
            100                 105                 110         


Gln Phe Asn Gln Asp Tyr Ala Ile Phe Glu Gln Ser Gly Lys Ile Ala 
        115                 120                 125             


Glu Asp Leu Arg Val Val Asn Ser Phe Ala Arg Met Ser Ile Ser Lys 
    130                 135                 140                 


Asp Gly Pro Asn Val Lys Gly Ala Met Phe Arg Glu Ala Leu Leu Ile 
145                 150                 155                 160 


Leu Gly Leu Ala Ser Pro Asp Glu Thr Met Glu Ser Val Leu Gln Lys 
                165                 170                 175     


Tyr Met Asn Ser Asn Leu Asp Arg Glu Arg Lys Ser Val Arg Asn Phe 
            180                 185                 190         


Val Ile Asn Asn Val Ile Gln Ser Arg Arg Phe His Tyr Leu Val Arg 
        195                 200                 205             


Tyr Gly Asn 
    210     


<210>  82
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  gut_metagenome_P13E0k2120140920_c3000072

<400>  82

Met Glu Arg Glu Val Lys Lys Pro Pro Lys Lys Ser Leu Ala Lys Ala 
1               5                   10                  15      


Ala Gly Leu Lys Ser Thr Phe Val Ile Ser Pro Gln Glu Lys Glu Leu 
            20                  25                  30          


Ala Met Thr Ala Phe Gly Arg Gly Asn Asp Ala Leu Leu Gln Lys Arg 
        35                  40                  45              


Ile Val Asp Gly Val Val Arg Asp Val Ala Gly Glu Lys Gln Gln Phe 
    50                  55                  60                  


Gln Val Gln Arg Gln Asp Glu Ser Arg Phe Arg Leu Gln Asn Ser Arg 
65                  70                  75                  80  


Leu Ala Asp Arg Thr Val Thr Ala Asp Asp Pro Leu His Arg Ala Glu 
                85                  90                  95      


Thr Pro Arg Arg Gln Pro Leu Gly Ala Gly Met Asp Gln Leu Arg Arg 
            100                 105                 110         


Lys Ala Ile Leu Glu Gln Lys Tyr Phe Gly Arg Thr Phe Asp Asp Asn 
        115                 120                 125             


Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile His Lys Met Leu 
    130                 135                 140                 


Ala Val Pro Ala Asn His Ile Val His Thr Leu Asn Leu Leu Gly Gly 
145                 150                 155                 160 


Tyr Gly Glu Thr Asp Phe Val Gly Met Leu Pro Ala Gly Leu Pro Tyr 
                165                 170                 175     


Asp Lys Leu Arg Val Val Lys Lys Lys Asn Gly Asp Thr Val Asp Ile 
            180                 185                 190         


Lys Ala Asp Ile Ala Ala Tyr Ala Lys Arg Pro Gln Leu Ala Tyr Leu 
        195                 200                 205             


Gly Ala Ala Phe Tyr Asp Val Thr Pro Gly Lys Ser Lys Arg Asp Ala 
    210                 215                 220                 


Ala Arg Gly Arg Val Lys Arg Glu Gln Asp Val Tyr Thr Ile Leu Ser 
225                 230                 235                 240 


Leu Met Ser Leu Leu Arg Gln Phe Cys Ala His Asp Ser Val Arg Ile 
                245                 250                 255     


Trp Gly Gln Asn Thr Pro Ala Ala Leu Tyr Gly Leu Gln Ala Leu Pro 
            260                 265                 270         


Gln Asp Met Lys Asp Leu Leu Asp Asp Gly Trp Arg Arg Ala Leu Gly 
        275                 280                 285             


Gly Val Asn Asp His Phe Leu Asp Thr Asn Lys Val Asn Leu Leu Thr 
    290                 295                 300                 


Leu Phe Glu Tyr Tyr Gly Ala Glu Thr Lys Gln Glu Arg Val Ala Leu 
305                 310                 315                 320 


Thr Gln Asp Phe Tyr Arg Phe Val Val Leu Lys Glu Gln Lys Asn Met 
                325                 330                 335     


Gly Phe Ser Leu Arg Arg Leu Arg Glu Glu Leu Leu Lys Leu Pro Asp 
            340                 345                 350         


Ala Ala Tyr Leu Thr Gly Gln Glu Tyr Asp Ser Val Arg Gln Lys Leu 
        355                 360                 365             


Tyr Met Leu Leu Asp Phe Leu Leu Cys Arg Leu Tyr Ala Gln Glu Arg 
    370                 375                 380                 


Ala Asp Arg Cys Glu Glu Leu Val Ser Ala Leu Arg Cys Ala Leu Ser 
385                 390                 395                 400 


Asp Glu Glu Lys Asp Ala Val Tyr Gln Ala Glu Ala Ala Ala Leu Trp 
                405                 410                 415     


Gln Ala Leu Gly Asp Thr Leu Arg Arg Glu Leu Leu Pro Leu Leu Lys 
            420                 425                 430         


Gly Lys Lys Leu Gln Asp Lys Asp Lys Lys Lys Leu Asp Glu Leu Gly 
        435                 440                 445             


Leu Ser Arg Asp Val Leu Asp Gly Val Leu Phe Arg Pro Ala Gln Gln 
    450                 455                 460                 


Gly Ser Arg Ala Asn Ala Asp Tyr Phe Cys Arg Leu Met His Leu Ser 
465                 470                 475                 480 


Thr Trp Phe Met Asp Gly Lys Glu Ile Asn Thr Leu Leu Thr Thr Leu 
                485                 490                 495     


Ile Ser Lys Leu Glu Asn Ile Asp Ser Leu Arg Ser Val Leu Glu Ser 
            500                 505                 510         


Met Gly Leu Ala Tyr Ser Phe Val Pro Ala Tyr Ala Met Phe Asp His 
        515                 520                 525             


Ser Arg Tyr Ile Ala Gly Gln Leu Arg Val Val Asn Asn Ile Ala Arg 
    530                 535                 540                 


Met Arg Lys Pro Ala Ile Gly Ala Lys Arg Glu Met Tyr Arg Ala Ala 
545                 550                 555                 560 


Val Val Leu Leu Gly Val Asp Ser Pro Glu Ala Ala Ala Ala Ile Thr 
                565                 570                 575     


Asp Asp Leu Leu Gln Ile Asp Pro Glu Thr Gly Lys Val Arg Pro Arg 
            580                 585                 590         


Gly Asp Ser Ala Arg Asp Thr Gly Leu Arg Asn Phe Val Ala Asn Asn 
        595                 600                 605             


Val Val Glu Ser Arg Arg Phe Thr Tyr Leu Leu Arg Tyr Met Thr Pro 
    610                 615                 620                 


Glu Gln Ala Arg Val Leu Ala Gln Asn Glu Lys Leu Ile Ala Phe Val 
625                 630                 635                 640 


Leu Ser Thr Val Pro Ser Ala Gln Leu Glu Arg Tyr Cys Arg Thr Cys 
                645                 650                 655     


Gly Arg Glu Asp Ile Thr Gly Arg Pro Ala Gln Ile Arg Tyr Leu Thr 
            660                 665                 670         


Ala Gln Ile Met Gly Val Arg Tyr Glu Ser Phe Thr Asp Val Glu Gln 
        675                 680                 685             


Arg Gly Arg Gly Asp Asn Pro Lys Lys Glu Arg Tyr Lys Ala Leu Ile 
    690                 695                 700                 


Gly Leu Tyr Leu Thr Val Leu Tyr Leu Ala Val Lys Asn Met Val Asn 
705                 710                 715                 720 


Cys Asn Ala Arg Tyr Val Ile Ala Phe Tyr Cys Arg Asp Arg Asp Thr 
                725                 730                 735     


Ala Leu Tyr Gln Lys Glu Val Cys Trp Tyr Asp Leu Glu Glu Asp Lys 
            740                 745                 750         


Lys Ser Gly Lys Gln Arg Gln Val Glu Asp Tyr Thr Ala Leu Thr Arg 
        755                 760                 765             


Tyr Phe Val Ser Gln Gly Tyr Leu Asn Arg His Ala Cys Gly Tyr Leu 
    770                 775                 780                 


Arg Ser Asn Met Asn Gly Ile Ser Asn Gly Leu Leu Ala Ala Tyr Arg 
785                 790                 795                 800 


Asn Ala Val Asp His Leu Asn Val Ile Pro Pro Leu Gly Ser Leu Cys 
                805                 810                 815     


Arg Asp Ile Gly Arg Val Asp Ser Tyr Phe Ala Leu Tyr His Tyr Ala 
            820                 825                 830         


Val Gln Gln Tyr Leu Asn Gly Arg Tyr Tyr Arg Lys Thr Pro Arg Glu 
        835                 840                 845             


Gln Glu Leu Phe Ala Ala Met Ala Gln His Arg Thr Trp Cys Ser Asp 
    850                 855                 860                 


Leu Val Lys Ala Leu Asn Thr Pro Phe Gly Tyr Asn Leu Ala Arg Tyr 
865                 870                 875                 880 


Lys Asn Leu Ser Ile Asp Gly Leu Phe Asp Arg Glu Gly Asp His Val 
                885                 890                 895     


Val Arg Glu Asp Gly Glu Lys Pro Ala Glu 
            900                 905     


<210>  83
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  gut_metagenome_P1E0k2120140920_c1000078

<400>  83

Met Glu Arg Glu Val Lys Lys Pro Pro Lys Lys Ser Leu Ala Lys Ala 
1               5                   10                  15      


Ala Gly Leu Lys Ser Thr Phe Val Ile Ser Pro Gln Glu Lys Glu Leu 
            20                  25                  30          


Ala Met Thr Ala Phe Gly Arg Gly Asn Asp Ala Leu Leu Gln Lys Arg 
        35                  40                  45              


Ile Val Asp Gly Val Val Arg Asp Val Ala Gly Glu Lys Gln Gln Phe 
    50                  55                  60                  


Gln Val Gln Arg Gln Asp Glu Ser Arg Phe Arg Leu Gln Asn Ser Arg 
65                  70                  75                  80  


Leu Ala Asp Arg Thr Val Thr Ala Asp Asp Pro Leu His Arg Ala Glu 
                85                  90                  95      


Thr Pro Arg Arg Gln Pro Leu Gly Ala Gly Met Asp Gln Leu Arg Arg 
            100                 105                 110         


Lys Ala Ile Leu Glu Gln Lys Tyr Phe Gly Arg Thr Phe Asp Asp Asn 
        115                 120                 125             


Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile His Lys Met Leu 
    130                 135                 140                 


Ala Val Pro Ala Asn His Ile Val His Thr Leu Asn Leu Leu Gly Gly 
145                 150                 155                 160 


Tyr Gly Glu Thr Asp Phe Val Gly Met Leu Pro Ala Gly Leu Pro Tyr 
                165                 170                 175     


Asp Lys Leu Arg Val Val Lys Lys Lys Asn Gly Asp Thr Val Asp Ile 
            180                 185                 190         


Lys Ala Asp Ile Ala Ala Tyr Ala Lys Arg Pro Gln Leu Ala Tyr Leu 
        195                 200                 205             


Gly Ala Ala Phe Tyr Asp Val Thr Pro Gly Lys Ser Lys Arg Asp Ala 
    210                 215                 220                 


Ala Arg Gly Arg Val Lys Arg Glu Gln Asp Val Tyr Ala Ile Leu Ser 
225                 230                 235                 240 


Leu Met Ser Leu Leu Arg Gln Phe Cys Ala His Asp Ser Val Arg Ile 
                245                 250                 255     


Trp Gly Gln Asn Thr Thr Ala Ala Leu Tyr His Leu Gln Ala Leu Pro 
            260                 265                 270         


Gln Asp Met Lys Asp Leu Leu Asp Asp Gly Trp Arg Arg Ala Leu Gly 
        275                 280                 285             


Gly Val Asn Asp His Phe Leu Asp Thr Asn Lys Val Asn Leu Leu Thr 
    290                 295                 300                 


Leu Phe Glu Tyr Tyr Gly Ala Glu Thr Lys Gln Ala Arg Val Ala Leu 
305                 310                 315                 320 


Thr Gln Asp Phe Tyr Arg Phe Val Val Leu Lys Glu Gln Lys Asn Met 
                325                 330                 335     


Gly Phe Ser Leu Arg Arg Leu Arg Glu Glu Leu Leu Lys Leu Pro Asp 
            340                 345                 350         


Ala Ala Tyr Leu Thr Gly Gln Glu Tyr Asp Ser Val Arg Gln Lys Leu 
        355                 360                 365             


Tyr Met Leu Leu Asp Phe Leu Leu Cys Arg Leu Tyr Ala Gln Glu Arg 
    370                 375                 380                 


Ala Asp Arg Cys Glu Glu Leu Val Ser Ala Leu Arg Cys Ala Leu Ser 
385                 390                 395                 400 


Asp Glu Glu Lys Asp Thr Val Tyr Gln Ala Glu Ala Ala Ala Leu Trp 
                405                 410                 415     


Gln Ala Leu Gly Asp Thr Leu Arg Arg Lys Leu Leu Pro Leu Leu Lys 
            420                 425                 430         


Gly Lys Lys Leu Gln Asp Lys Asp Lys Lys Lys Ser Asp Glu Leu Gly 
        435                 440                 445             


Leu Ser Arg Asp Val Leu Asp Gly Val Leu Phe Arg Pro Ala Gln Gln 
    450                 455                 460                 


Gly Ser Arg Ala Asn Ala Asp Tyr Phe Cys Arg Leu Met His Leu Ser 
465                 470                 475                 480 


Thr Trp Phe Met Asp Gly Lys Glu Ile Asn Thr Leu Leu Thr Thr Leu 
                485                 490                 495     


Ile Ser Lys Leu Glu Asn Ile Asp Ser Leu Arg Ser Val Leu Glu Ser 
            500                 505                 510         


Met Gly Leu Ala Tyr Ser Phe Val Pro Ala Tyr Ala Met Phe Asp His 
        515                 520                 525             


Ser Arg Tyr Ile Ala Gly Gln Leu Arg Val Val Asn Asn Ile Ala Arg 
    530                 535                 540                 


Met Arg Lys Pro Ala Ile Gly Ala Lys Arg Glu Met Tyr Arg Ala Ala 
545                 550                 555                 560 


Val Val Leu Leu Gly Val Asp Ser Pro Glu Ala Ala Ala Ala Ile Thr 
                565                 570                 575     


Asp Asp Leu Leu Gln Ile Asp Pro Glu Thr Gly Lys Val Arg Pro Arg 
            580                 585                 590         


Ser Asp Ser Ala Arg Asp Thr Gly Leu Arg Asn Phe Ile Ala Asn Asn 
        595                 600                 605             


Val Val Glu Ser Arg Arg Phe Thr Tyr Leu Leu Arg Tyr Met Thr Pro 
    610                 615                 620                 


Glu Gln Ala Arg Val Leu Ala Gln Asn Glu Lys Leu Ile Ala Phe Val 
625                 630                 635                 640 


Leu Ser Thr Val Pro Asp Thr Gln Leu Glu Arg Tyr Cys Arg Thr Cys 
                645                 650                 655     


Gly Arg Glu Asp Ile Thr Gly Arg Pro Ala Gln Ile Arg Tyr Leu Thr 
            660                 665                 670         


Ala Gln Ile Met Gly Val Arg Tyr Glu Ser Phe Thr Asp Val Glu Gln 
        675                 680                 685             


Arg Gly Arg Gly Asp Asn Pro Lys Lys Glu Arg Tyr Lys Ala Leu Ile 
    690                 695                 700                 


Gly Leu Tyr Leu Thr Val Leu Tyr Leu Ala Val Lys Asn Met Val Asn 
705                 710                 715                 720 


Cys Asn Ala Arg Tyr Val Ile Ala Phe Tyr Cys Arg Asp Arg Asp Thr 
                725                 730                 735     


Ala Leu Tyr Gln Lys Glu Val Cys Trp Tyr Asp Leu Glu Glu Asp Lys 
            740                 745                 750         


Lys Ser Gly Lys Gln Arg Gln Val Glu Asp Tyr Thr Ala Leu Thr Arg 
        755                 760                 765             


Tyr Phe Val Ser Gln Gly Tyr Leu Asn Arg His Ala Cys Gly Tyr Leu 
    770                 775                 780                 


Arg Ser Asn Met Asn Gly Ile Ser Asn Ser Leu Leu Thr Ala Tyr Arg 
785                 790                 795                 800 


Asn Ala Val Asp His Leu Asn Ala Ile Pro Pro Leu Gly Ser Leu Cys 
                805                 810                 815     


Arg Asp Ile Gly Arg Val Asp Ser Tyr Phe Ala Leu Tyr His Tyr Ala 
            820                 825                 830         


Val Gln Gln Tyr Leu Asn Gly Arg Tyr Tyr Arg Lys Thr Pro Arg Glu 
        835                 840                 845             


Gln Glu Leu Phe Ala Ala Met Ala Gln His Arg Thr Trp Cys Ser Asp 
    850                 855                 860                 


Leu Val Lys Ala Leu Asn Thr Pro Phe Gly Tyr Asn Leu Ala Arg Tyr 
865                 870                 875                 880 


Lys Asn Leu Ser Ile Asp Gly Leu Phe Asp Arg Glu Gly Asp His Val 
                885                 890                 895     


Val Arg Glu Asp Gly Glu Lys Pro Ala Glu 
            900                 905     


<210>  84
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig12990000099

<400>  84

Ile Asn Asp Leu Leu Thr Thr Leu Ile His Lys Phe Glu Asn Ile Ala 
1               5                   10                  15      


Ala Phe Leu His Val Ile Gln Ala Glu Lys Leu Pro Val Glu Phe Val 
            20                  25                  30          


Pro Glu Phe Gln Val Phe Ser Asp Ser Gln Lys Ile Ala Glu Glu Leu 
        35                  40                  45              


Arg Ile Ile Asn Ser Phe Ala Arg Met Asn Lys Pro Ser Ala Asn Ala 
    50                  55                  60                  


Arg Glu Ile Met Tyr Ile Glu Ala Phe Lys Val Leu Gly Met Ser Gly 
65                  70                  75                  80  


Asp Glu Lys Gln 
                


<210>  85
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig525000349

<400>  85

Met Ser Lys Lys Glu Asn Arg Lys Ser Tyr Val Lys Gly Leu Gly Leu 
1               5                   10                  15      


Lys Ser Thr Leu Val Ser Asp Ser Lys Val Tyr Leu Thr Thr Phe Ala 
            20                  25                  30          


Asp Gly Ser Asn Ala Lys Leu Glu Lys Cys Val Glu Asn Asn Lys Ile 
        35                  40                  45              


Ile Cys Ile Ser Asn Asp Lys Glu Ala Phe Ala Ala Ser Ile Ala Asn 
    50                  55                  60                  


Lys Asn Val Gly Tyr Lys Ile Lys Asn Asp Glu Lys Phe Arg His Pro 
65                  70                  75                  80  


Lys Gly Tyr Asp Ile Ile Ser Asn Asn Pro Leu Leu His Asn Asn Ser 
                85                  90                  95      


Val Gln Gln Asp Met Leu Gly Leu Lys Asn Val Leu Glu Lys Arg Tyr 
            100                 105                 110         


Phe Gly Lys Ser Ser Gly Gly Asp Asn Asn Leu Cys Ile Gln Ile Ile 
        115                 120                 125             


His Asn Ile Ile Asp Ile Glu Lys Ile Leu Ser Glu Tyr Ile Pro Asn 
    130                 135                 140                 


Val Val Tyr Ala Phe Asn Asn Ile Ala Gly Phe Lys Asp Glu His Asn 
145                 150                 155                 160 


Asn Ile Ile Asp Ile Ile Gly Thr Gln Thr Tyr Asn Ser Ser Tyr Thr 
                165                 170                 175     


Tyr Ala Asp Phe Ser Lys Asp Lys Ser Asp Lys Lys Tyr Ile Glu Phe 
            180                 185                 190         


Gln Lys Leu Leu Lys Asn Lys Arg Leu Gly Tyr Trp Gly Lys Ala Phe 
        195                 200                 205             


Phe Thr Gly Gln Gly Asn Asn Ala Lys Val Arg Gln Glu Asn Gln Cys 
    210                 215                 220                 


Phe His Ile Ile Ala Leu Leu Ile Ser Leu Arg Asn Trp Ala Thr His 
225                 230                 235                 240 


Ser Asn Glu Leu Asp Lys His Thr Lys Arg Thr Trp Leu Tyr Lys Leu 
                245                 250                 255     


Asp Asp Thr Asn Ile Leu Asn Ala Glu Tyr Val Lys Thr Leu Asn Tyr 
            260                 265                 270         


Leu Tyr Asp Thr Ile Ala Asp Glu Leu Thr Lys Ser Phe Ser Lys Asn 
        275                 280                 285             


Gly Ala Val Asn Val Asn Tyr Leu Ala Lys Lys Tyr Asn Ile Lys Asp 
    290                 295                 300                 


Asp Leu Pro Gly Phe Ser Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys 
305                 310                 315                 320 


Glu Gln Lys Asn Leu Gly Phe Asn Ile Ser Lys Leu Arg Glu Asn Met 
                325                 330                 335     


Leu Asp Phe Lys Asp Met Ser Val Ile 
            340                 345 


<210>  86
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig7229000302

<400>  86

Lys Lys Ile Ser Ser Leu Thr Lys Phe Cys Leu Gly Glu Ser Asp Glu 
1               5                   10                  15      


Lys Lys Leu Lys Ala Leu Ala Lys Lys Ser Leu Glu Glu Leu Lys Thr 
            20                  25                  30          


Thr Asn Ser Lys Leu Tyr Glu Asn Tyr Ile Lys Tyr Ser Asp Glu Arg 
        35                  40                  45              


Lys Ala Glu Glu Ala Lys Arg Gln Ile Asn Arg Glu Arg Ala Lys Thr 
    50                  55                  60                  


Ala Met Asn Ala His Leu Arg Asn Thr Lys Trp Asn Asp Ile Met Tyr 
65                  70                  75                  80  


Gly Gln Leu Lys Asp Leu Ala Asp Ser Lys Ser Arg Ile Cys Ser Glu 
                85                  90                  95      


Phe Arg Asn Lys Ala Ala His Leu Glu Val Ala Arg Tyr Ala His Met 
            100                 105                 110         


Tyr Ile Asn Asp Ile Ser Glu Val Lys Ser Tyr Phe Arg Leu Tyr His 
        115                 120                 125             


Tyr Ile Met Gln Arg Arg Ile Ile Asp Val Ile Glu Asn Asn Pro Lys 
    130                 135                 140                 


Ala Lys Tyr Glu Gly Lys Val Lys Val Tyr Phe Glu Asp Val Lys Lys 
145                 150                 155                 160 


Asn Lys Lys Tyr Asn Lys Asn Leu Leu Lys Leu Met Cys Val Pro Phe 
                165                 170                 175     


Gly Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Met Phe 
            180                 185                 190         


Asp Met Asn Glu Thr Asp Asn Ser Asp Lys Lys Lys Glu Lys 
        195                 200                 205     


<210>  87
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig3227000343

<400>  87

Ile Gly Asp Ile Ser Glu Val Asn Ser Tyr Phe Gln Leu Tyr His Tyr 
1               5                   10                  15      


Ile Met Gln Arg Ile Leu Ile Asp Lys Ile Gly Ser Lys Thr Thr Gly 
            20                  25                  30          


Lys Ala Lys Glu Tyr Phe Asp Ser Val Ile Val Asn Lys Lys Tyr Asp 
        35                  40                  45              


Asp Arg Leu Leu Lys Leu Leu Cys Ser Pro Leu Gly Tyr Cys Leu Thr 
    50                  55                  60                  


Arg Tyr Lys Asp Leu Ser Ile Glu Ala Leu Phe Asp Met Asn Glu Ala 
65                  70                  75                  80  


Ala Lys Tyr Asp Lys Leu Asn Lys Glu Arg Lys Asn Lys Lys Lys 
                85                  90                  95  


<210>  88
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig7030000469

<400>  88

Ser Ile Arg Ser Lys Leu Tyr Thr Met Met Asp Phe Val Ile Tyr Arg 
1               5                   10                  15      


Tyr Tyr Ile Glu Glu Ser Ala Lys Ala Ala Ala Glu Asn Lys Pro Ser 
            20                  25                  30          


Glu Ser Asp Ser Phe Val Ile Arg Leu Arg Gly Ser Phe Asn Glu Asn 
        35                  40                  45              


Gln Lys Glu Glu Leu Tyr Ile Glu Glu Ala Glu Arg Leu Trp Lys Lys 
    50                  55                  60                  


Phe Gly Glu Ile Met Leu Lys Ile Lys Glu Phe Arg Gly Glu Lys Val 
65                  70                  75                  80  


Lys Glu Tyr Lys Lys Glu Val Pro Arg Ile Glu Arg Ile Leu Pro His 
                85                  90                  95      


Gly Lys Asp Ile Ser Ala Phe Ser Lys Leu Met Tyr Met Leu Ser Met 
            100                 105                 110         


Phe Leu Asp 
        115 


<210>  89
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig5149000068

<400>  89

Phe Arg Asn Lys Val Ala His Leu Glu Ala Val Arg Tyr Ala His Leu 
1               5                   10                  15      


Tyr Ile Asn Asp Ile Ala Glu Val Asn Ser Tyr Phe Gln Leu Tyr His 
            20                  25                  30          


Tyr Ile Ile Gln Arg Arg Ile Met Ala Glu Cys Tyr Asp Lys Ser Ser 
        35                  40                  45              


Gly Lys Val Arg Glu Tyr Phe Asn Ala Val Asn Lys Glu Lys Lys Tyr 
    50                  55                  60                  


Asn Asp Arg Leu Leu Lys Leu Leu Cys Val Pro Phe Gly Tyr Cys Val 
65                  70                  75                  80  


Thr Arg Phe Lys Asp Leu Ser Ile Glu Ala Leu Phe Asp Lys Asn Glu 
                85                  90                  95      


Ala Asp Arg Phe Asp Lys Glu Lys Lys Lys Ala Glu Lys Lys 
            100                 105                 110 


<210>  90
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig400200045

<400>  90

Met Ile Glu Lys Lys Lys Ser Tyr Ala Lys Gly Met Gly Leu Lys Ser 
1               5                   10                  15      


Thr Ile Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Gly Asp Gly 
            20                  25                  30          


Ser Glu Ala Arg Leu Glu Lys Val Val Glu Asn Asp Ser Ile Lys Thr 
        35                  40                  45              


Leu His Glu Gly Glu Ala Phe Ser Ala Glu Met Thr Asp Asn Asn Ala 
    50                  55                  60                  


Gly Tyr Lys Ile Gly Asn Val Lys Phe Ser His Pro Asn Gly Tyr Asp 
65                  70                  75                  80  


Val Val Ala Asn 
                


<210>  91
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig10420000446

<400>  91

Ser Ser Lys Ser Val Ala Glu Lys Val Asn Ala Leu Thr Lys Ile Ile 
1               5                   10                  15      


Thr Gly Met Asn Tyr Asp Gln Phe Asp Ser Arg Arg Asn Val Ile Glu 
            20                  25                  30          


Asn Thr Gly Ala Gly Asn Ala Glu Arg Glu Lys Tyr Lys Lys Ile Ile 
        35                  40                  45              


Ser Leu Tyr Leu Thr Val Ile Tyr His Ile Leu Lys Asn Ile Val Asn 
    50                  55                  60                  


Ile Asn Ser Arg Tyr Val Ile Gly Phe His Cys Val Glu Arg Asp Ala 
65                  70                  75                  80  


Gln Leu Tyr Lys Glu Lys Gly Tyr Asp Ile Asn Leu Lys Lys 
                85                  90                  


<210>  92
<211>  967
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  new_flavefaciens,_strain_XPD3002

<400>  92

Met Ile Glu Lys Lys Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser 
1               5                   10                  15      


Thr Leu Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly 
            20                  25                  30          


Ser Asp Ala Arg Leu Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser 
        35                  40                  45              


Val Asn Glu Gly Glu Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala 
    50                  55                  60                  


Gly Tyr Lys Ile Gly Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala 
65                  70                  75                  80  


Val Val Ala Asn Asn Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met 
                85                  90                  95      


Leu Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala 
            100                 105                 110         


Asp Gly Asn Asp Asn Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp 
        115                 120                 125             


Ile Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val 
    130                 135                 140                 


Asn Asn Ile Ser Gly Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe 
145                 150                 155                 160 


Ser Thr Val Tyr Thr Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg 
                165                 170                 175     


Ala Ala Phe Asn Asn Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln 
            180                 185                 190         


Tyr Asp Glu Phe Asp Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe 
        195                 200                 205             


Gly Gln Ala Phe Phe Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr 
    210                 215                 220                 


Gly Asn Glu Cys Tyr Asp Ile Leu Ala Leu Leu Ser Gly Leu Arg His 
225                 230                 235                 240 


Trp Val Val His Asn Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp 
                245                 250                 255     


Leu Tyr Asn Leu Asp Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu 
            260                 265                 270         


Asn Tyr Leu Tyr Asp Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser 
        275                 280                 285             


Lys Asn Ser Ala Ala Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile 
    290                 295                 300                 


Asn Pro Ala Glu Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys 
305                 310                 315                 320 


Glu Gln Lys Asn Leu Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met 
                325                 330                 335     


Leu Asp Arg Lys Asp Met Ser Glu Ile Arg Lys Asn His Lys Val Phe 
            340                 345                 350         


Asp Ser Ile Arg Thr Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr 
        355                 360                 365             


Arg Tyr Tyr Ile Glu Glu Asp Ala Lys Val Ala Ala Ala Asn Lys Ser 
    370                 375                 380                 


Leu Pro Asp Asn Glu Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile 
385                 390                 395                 400 


Asn Leu Arg Gly Ser Phe Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr 
                405                 410                 415     


Asp Glu Ala Asn Arg Ile Trp Arg Lys Leu Glu Asn Ile Met His Asn 
            420                 425                 430         


Ile Lys Glu Phe Arg Gly Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp 
        435                 440                 445             


Ala Pro Arg Leu Pro Arg Ile Leu Pro Ala Gly Arg Asp Val Ser Ala 
    450                 455                 460                 


Phe Ser Lys Leu Met Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu 
465                 470                 475                 480 


Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln 
                485                 490                 495     


Ser Phe Leu Lys Val Met Pro Leu Ile Gly Val Asn Ala Lys Phe Val 
            500                 505                 510         


Glu Glu Tyr Ala Phe Phe Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu 
        515                 520                 525             


Arg Leu Ile Lys Ser Phe Ala Arg Met Gly Glu Pro Ile Ala Asp Ala 
    530                 535                 540                 


Arg Arg Ala Met Tyr Ile Asp Ala Ile Arg Ile Leu Gly Thr Asn Leu 
545                 550                 555                 560 


Ser Tyr Asp Glu Leu Lys Ala Leu Ala Asp Thr Phe Ser Leu Asp Glu 
                565                 570                 575     


Asn Gly Asn Lys Leu Lys Lys Gly Lys His Gly Met Arg Asn Phe Ile 
            580                 585                 590         


Ile Asn Asn Val Ile Ser Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr 
        595                 600                 605             


Gly Asp Pro Ala His Leu His Glu Ile Ala Lys Asn Glu Ala Val Val 
    610                 615                 620                 


Lys Phe Val Leu Gly Arg Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln 
625                 630                 635                 640 


Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys 
                645                 650                 655     


Asp Lys Gly Lys Ser Val Ser Glu Lys Val Asp Ala Leu Thr Lys Ile 
            660                 665                 670         


Ile Thr Gly Met Asn Tyr Asp Gln Phe Asp Lys Lys Arg Ser Val Ile 
        675                 680                 685             


Glu Asp Thr Gly Arg Glu Asn Ala Glu Arg Glu Lys Phe Lys Lys Ile 
    690                 695                 700                 


Ile Ser Leu Tyr Leu Thr Val Ile Tyr His Ile Leu Lys Asn Ile Val 
705                 710                 715                 720 


Asn Ile Asn Ala Arg Tyr Val Ile Gly Phe His Cys Val Glu Arg Asp 
                725                 730                 735     


Ala Gln Leu Tyr Lys Glu Lys Gly Tyr Asp Ile Asn Leu Lys Lys Leu 
            740                 745                 750         


Glu Glu Lys Gly Phe Ser Ser Val Thr Lys Leu Cys Ala Gly Ile Asp 
        755                 760                 765             


Glu Thr Ala Pro Asp Lys Arg Lys Asp Val Glu Lys Glu Met Ala Glu 
    770                 775                 780                 


Arg Ala Lys Glu Ser Ile Asp Ser Leu Glu Ser Ala Asn Pro Lys Leu 
785                 790                 795                 800 


Tyr Ala Asn Tyr Ile Lys Tyr Ser Asp Glu Lys Lys Ala Glu Glu Phe 
                805                 810                 815     


Thr Arg Gln Ile Asn Arg Glu Lys Ala Lys Thr Ala Leu Asn Ala Tyr 
            820                 825                 830         


Leu Arg Asn Thr Lys Trp Asn Val Ile Ile Arg Glu Asp Leu Leu Arg 
        835                 840                 845             


Ile Asp Asn Lys Thr Cys Thr Leu Phe Arg Asn Lys Ala Val His Leu 
    850                 855                 860                 


Glu Val Ala Arg Tyr Val His Ala Tyr Ile Asn Asp Ile Ala Glu Val 
865                 870                 875                 880 


Asn Ser Tyr Phe Gln Leu Tyr His Tyr Ile Met Gln Arg Ile Ile Met 
                885                 890                 895     


Asn Glu Arg Tyr Glu Lys Ser Ser Gly Lys Val Ser Glu Tyr Phe Asp 
            900                 905                 910         


Ala Val Asn Asp Glu Lys Lys Tyr Asn Asp Arg Leu Leu Lys Leu Leu 
        915                 920                 925             


Cys Val Pro Phe Gly Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile 
    930                 935                 940                 


Glu Ala Leu Phe Asp Arg Asn Glu Ala Ala Lys Phe Asp Lys Glu Lys 
945                 950                 955                 960 


Lys Lys Val Ser Gly Asn Ser 
                965         


<210>  93
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M26_Gut_metagenome_contig698000307

<400>  93

Met Ile Glu Lys Lys Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser 
1               5                   10                  15      


Thr Leu Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly 
            20                  25                  30          


Ser Asp Ala Lys Leu Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser 
        35                  40                  45              


Val Asn Glu Gly Glu Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala 
    50                  55                  60                  


Gly Tyr Lys Ile Gly Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala 
65                  70                  75                  80  


Val Val Ala Asn Asn Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met 
                85                  90                  95      


Leu Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala 
            100                 105                 110         


Asp Gly Asn Asp Asn Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp 
        115                 120                 125             


Ile Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ser Val 
    130                 135                 140                 


Thr Asp 
145     


<210>  94
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M36_Uncultured_Eubacterium_sp_TS28_c40956

<400>  94

Arg Ile Arg Phe Val Leu Ser Gly Ile Phe Val Asn Ala Phe Ser Ser 
1               5                   10                  15      


Lys His Gly Phe Glu Ser Gly Val Glu Ile Asn Thr Ser Asn Pro Thr 
            20                  25                  30          


His Arg Ser Gly Glu Ser Ser Pro Val Arg Gly Asp Met Leu Gly Leu 
        35                  40                  45              


Lys Ser Glu Leu Glu Lys Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn 
    50                  55                  60                  


Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu 
65                  70                  75                  80  


Ala Val Tyr Val Thr Asn Ile Val Tyr Ala Leu Asn Asn Met Leu Gly 
                85                  90                  95      


Val Lys Gly Ser Glu Ser His Asp Asp Phe Ile Gly Tyr Leu Ser Thr 
            100                 105                 110         


Asn Asn Thr Tyr Asp Val Phe Ile Asp Pro Asp Asn Ser Ser Leu Ser 
        115                 120                 125             


Asp Asp Lys Lys Ala Asn Val Arg Lys Ser Leu Ser Lys Phe Asn Val 
    130                 135                 140                 


Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys 
145                 150                 155                 160 


Thr Lys Asp Asn Arg Val Ser Glu Ala Tyr Lys Lys Arg Val Tyr His 
                165                 170                 175     


Met Leu Ala Ile Val Gly Gln Ile Arg Gln Cys Val Phe His Asp Lys 
            180                 185                 190         


Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser Phe Ile Asn Asn Ile Asp 
        195                 200                 205             


Pro Glu Tyr Arg Asp Thr Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys 
    210                 215                 220                 


Ser Ile Asn Lys Asp Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu 
225                 230                 235                 240 


Leu Ile Asp Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu 
                245                 250                 255     


Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser 
            260                 265                 270         


Ile Lys Lys Leu Arg Glu Lys Met Leu Glu Glu Tyr Gly Phe Arg Phe 
        275                 280                 285             


Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met 
    290                 295                 300                 


Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly 
305                 310                 315                 320 


Glu Ala Leu Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys 
                325                 330                 335     


Glu Gly Leu Tyr Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg 
            340                 345                 350         


Asn Asp Phe Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys 
        355                 360                 365             


Glu Leu Gly Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser 
    370                 375                 380                 


Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr 
385                 390                 395                 400 


Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr 
                405                 410                 415     


Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met 
            420                 425                 430         


Lys Ser Ser Ala Val Asn Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys 
        435                 440                 445             


Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys 
    450                 455                 460                 


Asn Ile Ala Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met 
465                 470                 475                 480 


Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp 
                485                 490                 495     


Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile 
            500                 505                 510         


His Gly Leu Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg 
        515                 520                 525             


Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val 
    530                 535                 540                 


Ala Glu Asn Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp 
545                 550                 555                 560 


Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met 
                565                 570                 575     


Asn Ser Ser Leu Glu Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys 
            580                 585                 590         


Asn Ile Ser Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly 
        595                 600                 605             


Gln Arg Lys Arg Arg Leu Arg Arg Gly Gln Lys Ala Val Ile Gly Leu 
    610                 615                 620                 


Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn 
625                 630                 635                 640 


Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu 
                645                 650                 655     


Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp 
            660                 665                 670         


Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro 
        675                 680                 685             


Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val 
    690                 695                 700                 


Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys 
705                 710                 715                 720 


Ile Ala His Leu 
                


<210>  95
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M12_gut_metagenome_P25C0k2120140920_c134000066

<400>  95

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr 
    210                 215                 


<210>  96
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  exemplary Cas13d sequence from human gut metagenome

<400>  96

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Met Tyr Lys Leu Met 
385                 390                 395                 400 


Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly 
                405                 410                 415     


Glu Ala Leu Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys 
            420                 425                 430         


Glu Gly Ile Tyr Ala Asp Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg 
        435                 440                 445             


Asn Asp Phe Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys 
    450                 455                 460                 


Glu Leu Gly Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser 
465                 470                 475                 480 


Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr 
                485                 490                 495     


Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr 
            500                 505                 510         


Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met 
        515                 520                 525             


Lys Ser Ser Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys 
    530                 535                 540                 


Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys 
545                 550                 555                 560 


Asn Ile Ala Ser Met Arg Lys Pro Ala Ser Ser Ala Lys Leu Thr Met 
                565                 570                 575     


Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp 
            580                 585                 590         


Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile 
        595                 600                 605             


His Gly Leu Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg 
    610                 615                 620                 


Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val 
625                 630                 635                 640 


Ala Lys Asn Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp 
                645                 650                 655     


Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met 
            660                 665                 670         


Asn Ser Ser Leu Glu Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys 
        675                 680                 685             


Asn Ile Ser Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly 
    690                 695                 700                 


Arg Glu Asn Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr 
705                 710                 715                 720 


Leu Thr Val Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala 
                725                 730                 735     


Arg Tyr Val Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr 
            740                 745                 750         


Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr 
        755                 760                 765             


Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu Cys Asp Asn Gly Asp Glu 
    770                 775                 780                 


Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val 
785                 790                 795                 800 


Glu Val Asp Ile Asn Asn Ala Asp Ser Asn Met Thr Arg Lys Tyr Arg 
                805                 810                 815     


Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile 
            820                 825                 830         


Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val 
        835                 840                 845             


Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu 
    850                 855                 860                 


Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys 
865                 870                 875                 880 


Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg 
                885                 890                 895     


Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu 
            900                 905                 910         


Thr Glu Lys 
        915 


<210>  97
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M10_gut_metagenome_P25C90k2120140920,_c28000041

<400>  97

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ser 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  98
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M11_gut_metagenome_P25C7k2120140920_c4078000105

<400>  98

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ser 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  99
<211>  636
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  gut_metagenome_P25C0k2120140920_c32000045

<400>  99

Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp 
1               5                   10                  15      


Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu 
            20                  25                  30          


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
        35                  40                  45              


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
    50                  55                  60                  


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
65                  70                  75                  80  


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
                85                  90                  95      


Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
            100                 105                 110         


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
        115                 120                 125             


Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu 
    130                 135                 140                 


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
145                 150                 155                 160 


Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
                165                 170                 175     


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
            180                 185                 190         


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
        195                 200                 205             


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
    210                 215                 220                 


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
225                 230                 235                 240 


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
                245                 250                 255     


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
            260                 265                 270         


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
        275                 280                 285             


Pro Ala Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
    290                 295                 300                 


Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
305                 310                 315                 320 


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
                325                 330                 335     


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
            340                 345                 350         


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
        355                 360                 365             


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
    370                 375                 380                 


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys 
385                 390                 395                 400 


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe 
                405                 410                 415     


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
            420                 425                 430         


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
        435                 440                 445             


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
    450                 455                 460                 


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
465                 470                 475                 480 


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
                485                 490                 495     


Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys 
            500                 505                 510         


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
        515                 520                 525             


Asp Ser Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
    530                 535                 540                 


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
545                 550                 555                 560 


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
                565                 570                 575     


Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp 
            580                 585                 590         


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
        595                 600                 605             


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
    610                 615                 620                 


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
625                 630                 635     


<210>  100
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M13_gut_metagenome_P23C7k2120140920_c3000067

<400>  100

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asn Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Asp Asp Tyr Glu Ala Asp Asp Ile Ile His Leu Tyr Tyr 
        355                 360                 365             


Asp Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys 
    370                 375                 380                 


Lys Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp 
385                 390                 395                 400 


Lys Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe 
                405                 410                 415     


Leu Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala 
            420                 425                 430         


Leu Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly 
        435                 440                 445             


Ile Tyr Ala Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp 
    450                 455                 460                 


Phe Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu 
465                 470                 475                 480 


Gly Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys 
                485                 490                 495     


Lys Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu 
            500                 505                 510         


Thr Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu 
        515                 520                 525             


Ile Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser 
    530                 535                 540                 


Ser Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe 
545                 550                 555                 560 


Asn Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile 
                565                 570                 575     


Ala Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg 
            580                 585                 590         


Asp Ala Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg 
        595                 600                 605             


Ile Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly 
    610                 615                 620                 


Leu Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val 
625                 630                 635                 640 


Tyr Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys 
                645                 650                 655     


Asn Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln 
            660                 665                 670         


Ile Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser 
        675                 680                 685             


Ser Leu Lys Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile 
    690                 695                 700                 


Arg Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu 
705                 710                 715                 720 


Asn Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr 
                725                 730                 735     


Val Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr 
            740                 745                 750         


Val Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu 
        755                 760                 765             


Ile Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile 
    770                 775                 780                 


Leu Ser Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro 
785                 790                 795                 800 


Asn Leu Phe Leu Lys Lys Asn Arg Arg Leu Arg Lys Cys Val Glu Val 
                805                 810                 815     


Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys 
            820                 825                 830         


Ile Ala His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp 
        835                 840                 845             


Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln 
    850                 855                 860                 


Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile 
865                 870                 875                 880 


Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe 
                885                 890                 895     


Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys 
            900                 905                 910         


Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu 
        915                 920                 925             


Lys 
    


<210>  101
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M5_gut_metagenome_P18E90k2120140920

<400>  101

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Ile Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Cys Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Val Ser 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Ala Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Gly Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  102
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M21_gut_metagenome_P18E0k2120140920

<400>  102

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Ile Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Cys Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Val Ser 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Ala Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Gly Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  103
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M7_gut_metagenome_P38C7k2120140920_c4841000003


<220>
<221>  misc_feature
<222>  (551)..(551)
<223>  Xaa can be any naturally occurring amino acid

<400>  103

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Phe 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Val Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Ser Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asn Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Asp Asp Tyr Glu Ala Asp Asp Ile Ile His Leu Tyr Tyr 
        355                 360                 365             


Asp Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys 
    370                 375                 380                 


Lys Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp 
385                 390                 395                 400 


Lys Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe 
                405                 410                 415     


Leu Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala 
            420                 425                 430         


Leu Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly 
        435                 440                 445             


Ile Tyr Ala Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp 
    450                 455                 460                 


Phe Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu 
465                 470                 475                 480 


Gly Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Ile Asp Ser Glu Lys 
                485                 490                 495     


Lys Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu 
            500                 505                 510         


Thr Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu 
        515                 520                 525             


Ile Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser 
    530                 535                 540                 


Ser Ala Val Asp Val Glu Xaa Glu Leu Thr Ala Gly Tyr Lys Leu Phe 
545                 550                 555                 560 


Asn Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile 
                565                 570                 575     


Ala Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg 
            580                 585                 590         


Asp Ala Leu Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg 
        595                 600                 605             


Ile Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly 
    610                 615                 620                 


Leu Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val 
625                 630                 635                 640 


Tyr Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys 
                645                 650                 655     


Asn Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln 
            660                 665                 670         


Ile Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser 
        675                 680                 685             


Ser Leu Gly Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile 
    690                 695                 700                 


Ser Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu 
705                 710                 715                 720 


Asn Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr 
                725                 730                 735     


Val Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr 
            740                 745                 750         


Val Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu 
        755                 760                 765             


Ile Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile 
    770                 775                 780                 


Leu Ser Gln Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe 
785                 790                 795                 800 


Leu Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn 
                805                 810                 815     


Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His 
            820                 825                 830         


Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Cys Thr 
        835                 840                 845             


Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile 
    850                 855                 860                 


Thr Lys Arg Glu Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu 
865                 870                 875                 880 


Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala 
                885                 890                 895     


Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925     


<210>  104
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ruminococcus_bicirculans

<400>  104

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  105
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  our_cloned_CAG_Ncas1

<400>  105

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr Leu Ala Ile Val Gly Gln Ile Arg Gln Cys 
        275                 280                 285             


Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser Phe 
    290                 295                 300                 


Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu Val 
305                 310                 315                 320 


Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly Asn Lys 
                325                 330                 335     


Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala Asp 
            340                 345                 350         


Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln Lys 
        355                 360                 365             


Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp Glu 
    370                 375                 380                 


Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg Ser Lys 
385                 390                 395                 400 


Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr Arg Asn 
                405                 410                 415     


Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser Met 
            420                 425                 430         


Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys Leu 
        435                 440                 445             


Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met Asn 
    450                 455                 460                 


Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp Glu 
465                 470                 475                 480 


Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr Phe 
                485                 490                 495     


Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu Ile 
            500                 505                 510         


Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys Glu 
        515                 520                 525             


Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu Leu 
    530                 535                 540                 


Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn Glu 
545                 550                 555                 560 


Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala Ser 
                565                 570                 575     


Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile Asp 
            580                 585                 590         


Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys Glu 
        595                 600                 605             


Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn Val 
    610                 615                 620                 


Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala Gln 
625                 630                 635                 640 


Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val Leu 
                645                 650                 655     


Gly Gly Ile Pro Asp Thr His Ile Glu Arg Tyr Tyr Lys Ser Cys Val 
            660                 665                 670         


Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu Leu 
        675                 680                 685             


Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val Lys 
    690                 695                 700                 


Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys Ala 
705                 710                 715                 720 


Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn Leu 
                725                 730                 735     


Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu Arg 
            740                 745                 750         


Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys Asn 
        755                 760                 765             


Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu Cys 
    770                 775                 780                 


Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys Arg 
785                 790                 795                 800 


Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met 
                805                 810                 815     


Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu 
            820                 825                 830         


Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser 
        835                 840                 845             


Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp 
    850                 855                 860                 


Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn 
865                 870                 875                 880 


His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly 
                885                 890                 895     


Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp 
            900                 905                 910         


Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920 


<210>  106
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  consensus_1


<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (386)..(386)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (789)..(790)
<223>  Xaa can be any naturally occurring amino acid

<400>  106

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Xaa Asn Asn Asp Tyr Asn Lys Thr 
                85                  90                  95      


Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn 
            100                 105                 110         


Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val 
        115                 120                 125             


Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro 
    130                 135                 140                 


Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe 
145                 150                 155                 160 


Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn 
                165                 170                 175     


Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val 
            180                 185                 190         


Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp 
        195                 200                 205             


Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Asp Val Phe Thr 
    210                 215                 220                 


His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys 
225                 230                 235                 240 


Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly 
                245                 250                 255     


Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Glu 
            260                 265                 270         


Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile 
        275                 280                 285             


Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu 
    290                 295                 300                 


Tyr Ser Phe Ile Asp Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp 
305                 310                 315                 320 


Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln 
                325                 330                 335     


Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Xaa Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Xaa Xaa Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  107
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M18_gut_metagenome_P22E0k2120140920_c3395000078

<400>  107

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asn Glu Ser Ser Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Gly 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  108
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M17_gut_metagenome_P22E90k2120140920_c114

<400>  108

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asn Glu Ser Ser Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Gly 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  109
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ruminococcus_sp_CAG57

<400>  109

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asp Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asn Glu Ser Ser Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Gly 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  110
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  gut_metagenome_P11E90k2120140920_c43000123

<400>  110

Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr 
1               5                   10                  15      


Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val 
            20                  25                  30          


Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser Met Thr Asp 
        35                  40                  45              


Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys Leu Trp Gly 
    50                  55                  60                  


Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met Asn Gly Asp 
65                  70                  75                  80  


Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp Glu Lys Ile 
                85                  90                  95      


Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys 
            100                 105                 110         


Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp 
        115                 120                 125             


Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu 
    130                 135                 140                 


Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu Leu Thr Ala 
145                 150                 155                 160 


Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe 
                165                 170                 175     


Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala Ser Ala Arg 
            180                 185                 190         


Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile Asp Asp Lys 
        195                 200                 205             


Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly 
    210                 215                 220                 


Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn Val Ile Glu 
225                 230                 235                 240 


Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile 
                245                 250                 255     


Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val Leu Gly Gly 
            260                 265                 270         


Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe 
        275                 280                 285             


Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu Leu Ala Arg 
    290                 295                 300                 


Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val Lys Gln Gln 
305                 310                 315                 320 


Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys Ala Val Ile 
                325                 330                 335     


Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn Leu Val Asn 
            340                 345                 350         


Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu Arg Asp Phe 
        355                 360                 365             


Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys 
    370                 375                 380                 


Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu Cys Asp Lys 
385                 390                 395                 400 


Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg Lys Cys Val 
                405                 410                 415     


Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg 
            420                 425                 430         


Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile 
        435                 440                 445             


Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val 
    450                 455                 460                 


Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys Gln Glu Asp 
465                 470                 475                 480 


Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys 
                485                 490                 495     


Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg 
            500                 505                 510         


Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu 
        515                 520                 525             


Thr Glu Lys 
    530     


<210>  111
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M6_gut_metagenome_P13E90k2120140920_c7000009

<400>  111

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Lys Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Val 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe 
                325                 330                 335     


Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  112
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M19_gut_metagenome_P17E90k2120140920

<400>  112

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Arg Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met His Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Thr Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Tyr Pro Glu Tyr Arg Asp Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Lys Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  113
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  gut_metagenome_P17E0k2120140920,_c87000043

<400>  113

Met Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
1               5                   10                  15      


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
            20                  25                  30          


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
        35                  40                  45              


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
    50                  55                  60                  


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
65                  70                  75                  80  


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
                85                  90                  95      


Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
            100                 105                 110         


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
        115                 120                 125             


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
    130                 135                 140                 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
145                 150                 155                 160 


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
                165                 170                 175     


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
            180                 185                 190         


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
        195                 200                 205             


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
    210                 215                 220                 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr 
225                 230                 


<210>  114
<211>  2859
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized Eubacterium siraeum nCas1

<400>  114
ggcaagaaga tccatgccag ggacctcagg gagcaaagaa agaccgatag gacagaaaag       60

ttcgccgatc agaacaagaa gagggaggct gagagagctg tgcccaaaaa agacgccgcc      120

gtctccgtga agagcgtgtc cagcgtcagc agcaagaagg acaacgtcac caagagcatg      180

gccaaggccg ccggagtgaa gtccgtcttt gctgtgggaa acaccgtgta catgacctcc      240

ttcggcaggg gcaacgatgc cgtgctggag cagaaaatcg tggacacctc ccatgagccc      300

ctgaatatcg acgatcccgc ctatcaactc aacgtggtga ccatgaatgg atacagcgtc      360

acaggccata gaggagagac agtgtccgcc gtgacagata atcccctgag gagattcaac      420

ggcaggaaga aggacgaacc cgagcagagc gtccctacag acatgctctg cctgaagccc      480

accctcgaga aaaaattttt tggaaaggag tttgatgaca acattcatat tcagctgatc      540

tataatatcc tggatatcga gaaaatcctg gccgtgtact ccaccaacgc catctacgct      600

ctcaacaaca tgtccgccga cgaaaacatc gagaactccg acttcttcat gaaaagaaca      660

acagacgaga cctttgacga cttcgagaag aagaaggaga gcaccaacag cagagagaaa      720

gctgactttg acgcctttga aaagttcatc ggaaactata ggctggccta tttcgctgac      780

gctttctacg tgaataaaaa gaaccccaag ggaaaggcca agaatgtcct gagggaggac      840

aaggagctct acagcgtgct gacactgatc ggaaagctga gacactggtg tgtccacagc      900

gaggaaggaa gggctgaatt ctggctgtac aagctggacg agctcaaaga cgatttcaag      960

aacgtcctgg atgtggtgta taacagaccc gtggaggaga tcaacaacag gttcatcgaa     1020

aataacaaag tcaacatcca gatcctgggc tccgtgtata agaacaccga catcgccgag     1080

ctggtgaggt cctactatga gttcctgatc accaaaaaat acaagaatat gggcttttcc     1140

atcaagaagc tcagggagag catgctggag ggcaagggct acgctgataa ggagtacgat     1200

agcgtgagaa ataagctgta ccagatgacc gatttcatcc tctacaccgg ctacatcaac     1260

gaagatagcg atagggctga cgacctggtg aacacactga ggagctccct caaggaggac     1320

gacaaaacaa ccgtctactg caaggaggcc gattacctgt ggaaaaagta cagggaaagc     1380

attagagaag tcgccgatgc cctggatggc gacaacatta agaagctgtc caagagcaat     1440

attgagattc aggaggataa gctgagaaaa tgtttcatta gctatgctga tagcgtgagc     1500

gagtttacca agctgatcta cctcctcaca agattcctga gcggcaagga gatcaatgac     1560

ctggtgacca ccctgatcaa caagttcgat aatattagat cctttctgga gattatggat     1620

gaactgggcc tggacaggac atttaccgcc gagtacagct tcttcgaagg ctccacaaag     1680

tacctggccg agctcgtgga gctgaatagc tttgtgaagt cctgctcctt cgacatcaat     1740

gccaagagga ccatgtacag ggacgccctg gatatcctgg gcatcgagtc cgacaagacc     1800

gaggaggata ttgagaagat gattgataat atcctgcaga tcgacgccaa cggagataaa     1860

aagctgaaga aaaacaacgg actgagaaac ttcatcgctt ccaacgtcat cgacagcaat     1920

agattcaaat acctggtcag gtacggcaac cccaagaaga ttagagagac agccaagtgc     1980

aagcccgctg tgaggttcgt gctgaacgaa attcccgacg cccagatcga aaggtactat     2040

gaggcttgct gccccaagaa caccgccctc tgcagcgcca ataagagaag ggagaagctg     2100

gccgacatga tcgctgagat caaattcgag aattttagcg atgccggcaa ttaccagaag     2160

gctaacgtca catccaggac cagcgaggcc gagatcaaga gaaaaaacca ggccattatt     2220

aggctctatc tgacagtgat gtatattatg ctgaaaaacc tggtgaacgt gaatgccagg     2280

tacgtcattg ccttccactg cgtggaaagg gacaccaagc tgtacgccga aagcggcctg     2340

gaagtgggca acatcgaaaa gaacaaaaca aacctcacca tggccgtgat gggagtgaaa     2400

ctcgaaaacg gaattatcaa gacagagttc gataagagct tcgccgagaa cgccgctaac     2460

agatacctga ggaacgccag gtggtataaa ctgatcctgg acaacctgaa aaaatccgag     2520

agagccgtgg tgaatgagtt cagaaatacc gtgtgccacc tgaatgccat caggaacatc     2580

aatatcaaca tcaaggaaat taaggaggtg gagaattatt tcgctctgta ccactacctg     2640

atccagaagc acctggagaa caggttcgcc gataagaagg tggaaaggga tacaggcgat     2700

ttcatcagca aactggagga gcacaagacc tattgcaaag actttgtgaa ggcttactgc     2760

accccctttg gctacaacct ggtgagatat aagaatctca ccattgacgg cctcttcgac     2820

aagaactacc ctggcaagga tgactccgat gagcagaag                            2859


<210>  115
<211>  2862
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized Eubacterium siraeum nCas1 HEPN-/-

<400>  115
ggcaagaaga tccatgccag ggacctcagg gagcaaagaa agaccgatag gacagaaaag       60

ttcgccgatc agaacaagaa gagggaggct gagagagctg tgcccaaaaa agacgccgcc      120

gtctccgtga agagcgtgtc cagcgtcagc agcaagaagg acaacgtcac caagagcatg      180

gccaaggccg ccggagtgaa gtccgtcttt gctgtgggaa acaccgtgta catgacctcc      240

ttcggcaggg gcaacgatgc cgtgctggag cagaaaatcg tggacacctc ccatgagccc      300

ctgaatatcg acgatcccgc ctatcaactc aacgtggtga ccatgaatgg atacagcgtc      360

acaggccata gaggagagac agtgtccgcc gtgacagata atcccctgag gagattcaac      420

ggcaggaaga aggacgaacc cgagcagagc gtccctacag acatgctctg cctgaagccc      480

accctcgaga aaaaattttt tggaaaggag tttgatgaca acattcatat tcagctgatc      540

tataatatcc tggatatcga gaaaatcctg gccgtgtact ccaccaacgc catctacgct      600

ctcaacaaca tgtccgccga cgaaaacatc gagaactccg acttcttcat gaaaagaaca      660

acagacgaga cctttgacga cttcgagaag aagaaggaga gcaccaacag cagagagaaa      720

gctgactttg acgcctttga aaagttcatc ggaaactata ggctggccta tttcgctgac      780

gctttctacg tgaataaaaa gaaccccaag ggaaaggcca agaatgtcct gagggaggac      840

aaggagctct acagcgtgct gacactgatc ggaaagctgg cacactggtg tgtcgccagc      900

gaggaaggaa gggctgaatt ctggctgtac aagctggacg agctcaaaga cgatttcaag      960

aacgtcctgg atgtggtgta taacagaccc gtggaggaga tcaacaacag gttcatcgaa     1020

aataacaaag tcaacatcca gatcctgggc tccgtgtata agaacaccga catcgccgag     1080

ctggtgaggt cctactatga gttcctgatc accaaaaaat acaagaatat gggcttttcc     1140

atcaagaagc tcagggagag catgctggag ggcaagggct acgctgataa ggagtacgat     1200

agcgtgagaa ataagctgta ccagatgacc gatttcatcc tctacaccgg ctacatcaac     1260

gaagatagcg atagggctga cgacctggtg aacacactga ggagctccct caaggaggac     1320

gacaaaacaa ccgtctactg caaggaggcc gattacctgt ggaaaaagta cagggaaagc     1380

attagagaag tcgccgatgc cctggatggc gacaacatta agaagctgtc caagagcaat     1440

attgagattc aggaggataa gctgagaaaa tgtttcatta gctatgctga tagcgtgagc     1500

gagtttacca agctgatcta cctcctcaca agattcctga gcggcaagga gatcaatgac     1560

ctggtgacca ccctgatcaa caagttcgat aatattagat cctttctgga gattatggat     1620

gaactgggcc tggacaggac atttaccgcc gagtacagct tcttcgaagg ctccacaaag     1680

tacctggccg agctcgtgga gctgaatagc tttgtgaagt cctgctcctt cgacatcaat     1740

gccaagagga ccatgtacag ggacgccctg gatatcctgg gcatcgagtc cgacaagacc     1800

gaggaggata ttgagaagat gattgataat atcctgcaga tcgacgccaa cggagataaa     1860

aagctgaaga aaaacaacgg actgagaaac ttcatcgctt ccaacgtcat cgacagcaat     1920

agattcaaat acctggtcag gtacggcaac cccaagaaga ttagagagac agccaagtgc     1980

aagcccgctg tgaggttcgt gctgaacgaa attcccgacg cccagatcga aaggtactat     2040

gaggcttgct gccccaagaa caccgccctc tgcagcgcca ataagagaag ggagaagctg     2100

gccgacatga tcgctgagat caaattcgag aattttagcg atgccggcaa ttaccagaag     2160

gctaacgtca catccaggac cagcgaggcc gagatcaaga gaaaaaacca ggccattatt     2220

aggctctatc tgacagtgat gtatattatg ctgaaaaacc tggtgaacgt gaatgccagg     2280

tacgtcattg ccttccactg cgtggaaagg gacaccaagc tgtacgccga aagcggcctg     2340

gaagtgggca acatcgaaaa gaacaaaaca aacctcacca tggccgtgat gggagtgaaa     2400

ctcgaaaacg gaattatcaa gacagagttc gataagagct tcgccgagaa cgccgctaac     2460

agatacctga ggaacgccag gtggtataaa ctgatcctgg acaacctgaa aaaatccgag     2520

agagccgtgg tgaatgagtt cgcaaatacc gtgtgcgccc tgaatgccat caggaacatc     2580

aatatcaaca tcaaggaaat taaggaggtg gagaattatt tcgctctgta ccactacctg     2640

atccagaagc acctggagaa caggttcgcc gataagaagg tggaaaggga tacaggcgat     2700

ttcatcagca aactggagga gcacaagacc tattgcaaag actttgtgaa ggcttactgc     2760

accccctttg gctacaacct ggtgagatat aagaatctca ccattgacgg cctcttcgac     2820

aagaactacc ctggcaagga tgactccgat gagcagaagt ga                        2862


<210>  116
<211>  2892
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized Eubacterium siraeum nCas1 with N-terminal  NLS

<400>  116
agccccaaga agaagagaaa ggtggaggcc agcggcaaga agatccatgc cagggacctc       60

agggagcaaa gaaagaccga taggacagaa aagttcgccg atcagaacaa gaagagggag      120

gctgagagag ctgtgcccaa aaaagacgcc gccgtctccg tgaagagcgt gtccagcgtc      180

agcagcaaga aggacaacgt caccaagagc atggccaagg ccgccggagt gaagtccgtc      240

tttgctgtgg gaaacaccgt gtacatgacc tccttcggca ggggcaacga tgccgtgctg      300

gagcagaaaa tcgtggacac ctcccatgag cccctgaata tcgacgatcc cgcctatcaa      360

ctcaacgtgg tgaccatgaa tggatacagc gtcacaggcc atagaggaga gacagtgtcc      420

gccgtgacag ataatcccct gaggagattc aacggcagga agaaggacga acccgagcag      480

agcgtcccta cagacatgct ctgcctgaag cccaccctcg agaaaaaatt ttttggaaag      540

gagtttgatg acaacattca tattcagctg atctataata tcctggatat cgagaaaatc      600

ctggccgtgt actccaccaa cgccatctac gctctcaaca acatgtccgc cgacgaaaac      660

atcgagaact ccgacttctt catgaaaaga acaacagacg agacctttga cgacttcgag      720

aagaagaagg agagcaccaa cagcagagag aaagctgact ttgacgcctt tgaaaagttc      780

atcggaaact ataggctggc ctatttcgct gacgctttct acgtgaataa aaagaacccc      840

aagggaaagg ccaagaatgt cctgagggag gacaaggagc tctacagcgt gctgacactg      900

atcggaaagc tgagacactg gtgtgtccac agcgaggaag gaagggctga attctggctg      960

tacaagctgg acgagctcaa agacgatttc aagaacgtcc tggatgtggt gtataacaga     1020

cccgtggagg agatcaacaa caggttcatc gaaaataaca aagtcaacat ccagatcctg     1080

ggctccgtgt ataagaacac cgacatcgcc gagctggtga ggtcctacta tgagttcctg     1140

atcaccaaaa aatacaagaa tatgggcttt tccatcaaga agctcaggga gagcatgctg     1200

gagggcaagg gctacgctga taaggagtac gatagcgtga gaaataagct gtaccagatg     1260

accgatttca tcctctacac cggctacatc aacgaagata gcgatagggc tgacgacctg     1320

gtgaacacac tgaggagctc cctcaaggag gacgacaaaa caaccgtcta ctgcaaggag     1380

gccgattacc tgtggaaaaa gtacagggaa agcattagag aagtcgccga tgccctggat     1440

ggcgacaaca ttaagaagct gtccaagagc aatattgaga ttcaggagga taagctgaga     1500

aaatgtttca ttagctatgc tgatagcgtg agcgagttta ccaagctgat ctacctcctc     1560

acaagattcc tgagcggcaa ggagatcaat gacctggtga ccaccctgat caacaagttc     1620

gataatatta gatcctttct ggagattatg gatgaactgg gcctggacag gacatttacc     1680

gccgagtaca gcttcttcga aggctccaca aagtacctgg ccgagctcgt ggagctgaat     1740

agctttgtga agtcctgctc cttcgacatc aatgccaaga ggaccatgta cagggacgcc     1800

ctggatatcc tgggcatcga gtccgacaag accgaggagg atattgagaa gatgattgat     1860

aatatcctgc agatcgacgc caacggagat aaaaagctga agaaaaacaa cggactgaga     1920

aacttcatcg cttccaacgt catcgacagc aatagattca aatacctggt caggtacggc     1980

aaccccaaga agattagaga gacagccaag tgcaagcccg ctgtgaggtt cgtgctgaac     2040

gaaattcccg acgcccagat cgaaaggtac tatgaggctt gctgccccaa gaacaccgcc     2100

ctctgcagcg ccaataagag aagggagaag ctggccgaca tgatcgctga gatcaaattc     2160

gagaatttta gcgatgccgg caattaccag aaggctaacg tcacatccag gaccagcgag     2220

gccgagatca agagaaaaaa ccaggccatt attaggctct atctgacagt gatgtatatt     2280

atgctgaaaa acctggtgaa cgtgaatgcc aggtacgtca ttgccttcca ctgcgtggaa     2340

agggacacca agctgtacgc cgaaagcggc ctggaagtgg gcaacatcga aaagaacaaa     2400

acaaacctca ccatggccgt gatgggagtg aaactcgaaa acggaattat caagacagag     2460

ttcgataaga gcttcgccga gaacgccgct aacagatacc tgaggaacgc caggtggtat     2520

aaactgatcc tggacaacct gaaaaaatcc gagagagccg tggtgaatga gttcagaaat     2580

accgtgtgcc acctgaatgc catcaggaac atcaatatca acatcaagga aattaaggag     2640

gtggagaatt atttcgctct gtaccactac ctgatccaga agcacctgga gaacaggttc     2700

gccgataaga aggtggaaag ggatacaggc gatttcatca gcaaactgga ggagcacaag     2760

acctattgca aagactttgt gaaggcttac tgcaccccct ttggctacaa cctggtgaga     2820

tataagaatc tcaccattga cggcctcttc gacaagaact accctggcaa ggatgactcc     2880

gatgagcaga ag                                                         2892


<210>  117
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized Eubacterium siraeum nCas1 with N- and  C-terminal NLS tags

<400>  117
agccccaaga agaagagaaa ggtggaggcc agcggcaaga agatccatgc cagggacctc       60

agggagcaaa gaaagaccga taggacagaa aagttcgccg atcagaacaa gaagagggag      120

gctgagagag ctgtgcccaa aaaagacgcc gccgtctccg tgaagagcgt gtccagcgtc      180

agcagcaaga aggacaacgt caccaagagc atggccaagg ccgccggagt gaagtccgtc      240

tttgctgtgg gaaacaccgt gtacatgacc tccttcggca ggggcaacga tgccgtgctg      300

gagcagaaaa tcgtggacac ctcccatgag cccctgaata tcgacgatcc cgcctatcaa      360

ctcaacgtgg tgaccatgaa tggatacagc gtcacaggcc atagaggaga gacagtgtcc      420

gccgtgacag ataatcccct gaggagattc aacggcagga agaaggacga acccgagcag      480

agcgtcccta cagacatgct ctgcctgaag cccaccctcg agaaaaaatt ttttggaaag      540

gagtttgatg acaacattca tattcagctg atctataata tcctggatat cgagaaaatc      600

ctggccgtgt actccaccaa cgccatctac gctctcaaca acatgtccgc cgacgaaaac      660

atcgagaact ccgacttctt catgaaaaga acaacagacg agacctttga cgacttcgag      720

aagaagaagg agagcaccaa cagcagagag aaagctgact ttgacgcctt tgaaaagttc      780

atcggaaact ataggctggc ctatttcgct gacgctttct acgtgaataa aaagaacccc      840

aagggaaagg ccaagaatgt cctgagggag gacaaggagc tctacagcgt gctgacactg      900

atcggaaagc tgagacactg gtgtgtccac agcgaggaag gaagggctga attctggctg      960

tacaagctgg acgagctcaa agacgatttc aagaacgtcc tggatgtggt gtataacaga     1020

cccgtggagg agatcaacaa caggttcatc gaaaataaca aagtcaacat ccagatcctg     1080

ggctccgtgt ataagaacac cgacatcgcc gagctggtga ggtcctacta tgagttcctg     1140

atcaccaaaa aatacaagaa tatgggcttt tccatcaaga agctcaggga gagcatgctg     1200

gagggcaagg gctacgctga taaggagtac gatagcgtga gaaataagct gtaccagatg     1260

accgatttca tcctctacac cggctacatc aacgaagata gcgatagggc tgacgacctg     1320

gtgaacacac tgaggagctc cctcaaggag gacgacaaaa caaccgtcta ctgcaaggag     1380

gccgattacc tgtggaaaaa gtacagggaa agcattagag aagtcgccga tgccctggat     1440

ggcgacaaca ttaagaagct gtccaagagc aatattgaga ttcaggagga taagctgaga     1500

aaatgtttca ttagctatgc tgatagcgtg agcgagttta ccaagctgat ctacctcctc     1560

acaagattcc tgagcggcaa ggagatcaat gacctggtga ccaccctgat caacaagttc     1620

gataatatta gatcctttct ggagattatg gatgaactgg gcctggacag gacatttacc     1680

gccgagtaca gcttcttcga aggctccaca aagtacctgg ccgagctcgt ggagctgaat     1740

agctttgtga agtcctgctc cttcgacatc aatgccaaga ggaccatgta cagggacgcc     1800

ctggatatcc tgggcatcga gtccgacaag accgaggagg atattgagaa gatgattgat     1860

aatatcctgc agatcgacgc caacggagat aaaaagctga agaaaaacaa cggactgaga     1920

aacttcatcg cttccaacgt catcgacagc aatagattca aatacctggt caggtacggc     1980

aaccccaaga agattagaga gacagccaag tgcaagcccg ctgtgaggtt cgtgctgaac     2040

gaaattcccg acgcccagat cgaaaggtac tatgaggctt gctgccccaa gaacaccgcc     2100

ctctgcagcg ccaataagag aagggagaag ctggccgaca tgatcgctga gatcaaattc     2160

gagaatttta gcgatgccgg caattaccag aaggctaacg tcacatccag gaccagcgag     2220

gccgagatca agagaaaaaa ccaggccatt attaggctct atctgacagt gatgtatatt     2280

atgctgaaaa acctggtgaa cgtgaatgcc aggtacgtca ttgccttcca ctgcgtggaa     2340

agggacacca agctgtacgc cgaaagcggc ctggaagtgg gcaacatcga aaagaacaaa     2400

acaaacctca ccatggccgt gatgggagtg aaactcgaaa acggaattat caagacagag     2460

ttcgataaga gcttcgccga gaacgccgct aacagatacc tgaggaacgc caggtggtat     2520

aaactgatcc tggacaacct gaaaaaatcc gagagagccg tggtgaatga gttcagaaat     2580

accgtgtgcc acctgaatgc catcaggaac atcaatatca acatcaagga aattaaggag     2640

gtggagaatt atttcgctct gtaccactac ctgatccaga agcacctgga gaacaggttc     2700

gccgataaga aggtggaaag ggatacaggc gatttcatca gcaaactgga ggagcacaag     2760

acctattgca aagactttgt gaaggcttac tgcaccccct ttggctacaa cctggtgaga     2820

tataagaatc tcaccattga cggcctcttc gacaagaact accctggcaa ggatgactcc     2880

gatgagcaga agggatccgg acctaagaaa aagaggaagg tggcggccgc t              2931


<210>  118
<211>  2754
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized uncultured Ruminococcus sp. nCas1

<400>  118
gccaagaaga acaagatgaa acccagggag ctgagagagg ctcagaagaa ggctaggcaa       60

ctgaaagccg ccgagatcaa taacaatgcc gcccctgcca tcgccgctat gcccgctgcc      120

gaagtcatcg ctcccgccgc cgaaaagaag aagagctccg tgaaagccgc tggaatgaag      180

tccattctgg tgtccgagaa caaaatgtat atcacctcct tcggcaaagg caattccgct      240

gtgctggagt atgaggtgga caacaacgac tacaatcaga cccagctcag cagcaaggat      300

aactccaaca tccagctggg cggcgtgaat gaagtgaata tcaccttcag cagcaagcac      360

ggatttgagt ccggagtcga gattaacaca agcaacccta cccacaggtc cggagaaagc      420

agccctgtca gaggagacat gctgggactg aaaagcgagc tggagaagag attctttgga      480

aagacctttg atgacaatat ccacatccag ctcatttaca acatcctgga tatcgagaaa      540

atcctggccg tgtatgtgac caacatcgtg tacgctctga acaacatgct cggcgtcaag      600

ggcagcgagt cccacgacga ctttattggc tatctgtcca ccaacaatat ttacgatgtc      660

ttcattgacc ccgacaacag cagcctctcc gacgacaaaa aagccaacgt caggaagagc      720

ctcagcaaat tcaacgccct gctgaagacc aagaggctcg gatactttgg cctggaggaa      780

cccaagacca aggacaacag agtgagccag gcctataaga aaagggtgta ccacatgctg      840

gccatcgtgg gccagatcag acagtgcgtg ttccatgaca agtccggcgc caagagattc      900

gacctgtact ccttcattaa caacatcgac cctgagtaca gggatacact ggattacctc      960

gtggaggaga ggctgaagag catcaacaaa gactttattg aggacaacaa agtcaacatc     1020

agcctgctga tcgatatgat gaagggctac gaagctgacg acatcatcag gctgtactat     1080

gatttcattg tcctgaagag ccagaagaac ctgggattct ccattaagaa actgagagaa     1140

aagatgctcg acgagtacgg cttcaggttc aaggacaagc agtatgacag cgtgagatcc     1200

aagatgtaca agctgatgga ttttctcctg ttttgcaact attacaggaa cgacatcgcc     1260

gccggcgaat ccctggtcag gaaactgaga ttcagcatga ccgacgacga gaaggaaggc     1320

atctacgccg acgaagccgc taagctgtgg ggaaaattta gaaatgactt cgagaacatc     1380

gctgaccaca tgaacggcga tgtgatcaag gagctcggca aggctgacat ggatttcgac     1440

gagaagatcc tggattccga gaagaagaat gccagcgatc tgctgtactt cagcaagatg     1500

atttacatgc tcacatattt tctcgatggc aaggagatca acgatctcct gaccacactg     1560

atcagcaagt tcgacaacat taaagagttc ctcaaaatta tgaaatccag cgccgtggat     1620

gtcgagtgcg aactcaccgc cggctacaag ctcttcaacg acagccagag gatcaccaat     1680

gagctgttca ttgtgaaaaa tatcgctagc atgaggaaac ccgccgcctc cgctaaactg     1740

acaatgttta gagatgccct caccatcctg ggcatcgacg ataagatcac agacgacaga     1800

attagcggaa tcctgaagct caaggaaaag ggcaagggaa tccatggcct cagaaatttc     1860

attaccaata acgtgatcga aagcagcagg ttcgtgtatc tgatcaagta cgccaatgcc     1920

caaaagatca gggaggtggc caagaacgaa aaggtggtga tgttcgtgct gggcggcatt     1980

cctgacacac agatcgaaag gtactacaag agctgtgtgg agttccccga tatgaactcc     2040

agcctgggcg tgaagagatc cgaactggct aggatgatca agaatattag cttcgacgac     2100

ttcaagaacg tgaagcaaca ggccaaagga agggagaacg tcgccaaaga gagagccaag     2160

gccgtgatcg gactctacct gaccgtcatg tacctcctcg tgaagaacct ggtgaacgtg     2220

aacgctagat acgtcatcgc catccattgc ctcgagaggg acttcggact gtacaaggag     2280

atcattcccg agctggccag caaaaatctc aagaacgatt acagaatcct gagccaaacc     2340

ctgtgcgagc tgtgtgacaa gtcccccaac ctgtttctga agaagaatga aaggctgaga     2400

aagtgcgtcg aagtcgacat caacaacgct gacagctcca tgaccaggaa atacaggaac     2460

tgtatcgccc atctgaccgt ggtgagggaa ctcaaggagt acatcggaga tatctgcacc     2520

gtggactcct acttcagcat ttatcactac gtgatgcaga ggtgcattac caagagagaa     2580

aatgacacaa agcaggagga gaagattaag tacgaggacg atctgctgaa aaaccacgga     2640

tacaccaagg atttcgtcaa ggccctcaat agccccttcg gctacaatat ccctaggttt     2700

aaaaacctga gcatcgagca gctgtttgac agaaatgaat acctgacaga gaag           2754


<210>  119
<211>  2757
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized uncultured Ruminococcus sp. nCas1 HEPN-/-

<400>  119
atggccaaga agaacaagat gaaacccagg gagctgagag aggctcagaa gaaggctagg       60

caactgaaag ccgccgagat caataacaat gccgcccctg ccatcgccgc tatgcccgct      120

gccgaagtca tcgctcccgc cgccgaaaag aagaagagct ccgtgaaagc cgctggaatg      180

aagtccattc tggtgtccga gaacaaaatg tatatcacct ccttcggcaa aggcaattcc      240

gctgtgctgg agtatgaggt ggacaacaac gactacaatc agacccagct cagcagcaag      300

gataactcca acatccagct gggcggcgtg aatgaagtga atatcacctt cagcagcaag      360

cacggatttg agtccggagt cgagattaac acaagcaacc ctacccacag gtccggagaa      420

agcagccctg tcagaggaga catgctggga ctgaaaagcg agctggagaa gagattcttt      480

ggaaagacct ttgatgacaa tatccacatc cagctcattt acaacatcct ggatatcgag      540

aaaatcctgg ccgtgtatgt gaccaacatc gtgtacgctc tgaacaacat gctcggcgtc      600

aagggcagcg agtcccacga cgactttatt ggctatctgt ccaccaacaa tatttacgat      660

gtcttcattg accccgacaa cagcagcctc tccgacgaca aaaaagccaa cgtcaggaag      720

agcctcagca aattcaacgc cctgctgaag accaagaggc tcggatactt tggcctggag      780

gaacccaaga ccaaggacaa cagagtgagc caggcctata agaaaagggt gtaccacatg      840

ctggccatcg tgggccagat cgcacagtgc gtgttcgctg acaagtccgg cgccaagaga      900

ttcgacctgt actccttcat taacaacatc gaccctgagt acagggatac actggattac      960

ctcgtggagg agaggctgaa gagcatcaac aaagacttta ttgaggacaa caaagtcaac     1020

atcagcctgc tgatcgatat gatgaagggc tacgaagctg acgacatcat caggctgtac     1080

tatgatttca ttgtcctgaa gagccagaag aacctgggat tctccattaa gaaactgaga     1140

gaaaagatgc tcgacgagta cggcttcagg ttcaaggaca agcagtatga cagcgtgaga     1200

tccaagatgt acaagctgat ggattttctc ctgttttgca actattacag gaacgacatc     1260

gccgccggcg aatccctggt caggaaactg agattcagca tgaccgacga cgagaaggaa     1320

ggcatctacg ccgacgaagc cgctaagctg tggggaaaat ttagaaatga cttcgagaac     1380

atcgctgacc acatgaacgg cgatgtgatc aaggagctcg gcaaggctga catggatttc     1440

gacgagaaga tcctggattc cgagaagaag aatgccagcg atctgctgta cttcagcaag     1500

atgatttaca tgctcacata ttttctcgat ggcaaggaga tcaacgatct cctgaccaca     1560

ctgatcagca agttcgacaa cattaaagag ttcctcaaaa ttatgaaatc cagcgccgtg     1620

gatgtcgagt gcgaactcac cgccggctac aagctcttca acgacagcca gaggatcacc     1680

aatgagctgt tcattgtgaa aaatatcgct agcatgagga aacccgccgc ctccgctaaa     1740

ctgacaatgt ttagagatgc cctcaccatc ctgggcatcg acgataagat cacagacgac     1800

agaattagcg gaatcctgaa gctcaaggaa aagggcaagg gaatccatgg cctcagaaat     1860

ttcattacca ataacgtgat cgaaagcagc aggttcgtgt atctgatcaa gtacgccaat     1920

gcccaaaaga tcagggaggt ggccaagaac gaaaaggtgg tgatgttcgt gctgggcggc     1980

attcctgaca cacagatcga aaggtactac aagagctgtg tggagttccc cgatatgaac     2040

tccagcctgg gcgtgaagag atccgaactg gctaggatga tcaagaatat tagcttcgac     2100

gacttcaaga acgtgaagca acaggccaaa ggaagggaga acgtcgccaa agagagagcc     2160

aaggccgtga tcggactcta cctgaccgtc atgtacctcc tcgtgaagaa cctggtgaac     2220

gtgaacgcta gatacgtcat cgccatccat tgcctcgaga gggacttcgg actgtacaag     2280

gagatcattc ccgagctggc cagcaaaaat ctcaagaacg attacagaat cctgagccaa     2340

accctgtgcg agctgtgtga caagtccccc aacctgtttc tgaagaagaa tgaaaggctg     2400

agaaagtgcg tcgaagtcga catcaacaac gctgacagct ccatgaccag gaaatacgcg     2460

aactgtatcg ccgctctgac cgtggtgagg gaactcaagg agtacatcgg agatatctgc     2520

accgtggact cctacttcag catttatcac tacgtgatgc agaggtgcat taccaagaga     2580

gaaaatgaca caaagcagga ggagaagatt aagtacgagg acgatctgct gaaaaaccac     2640

ggatacacca aggatttcgt caaggccctc aatagcccct tcggctacaa tatccctagg     2700

tttaaaaacc tgagcatcga gcagctgttt gacagaaatg aatacctgac agagaag        2757


<210>  120
<211>  2787
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized uncultured Ruminococcus sp. nCas1 with N-terminal NLS

<400>  120
agccccaaga agaagagaaa ggtggaggcc agcgccaaga agaacaagat gaaacccagg       60

gagctgagag aggctcagaa gaaggctagg caactgaaag ccgccgagat caataacaat      120

gccgcccctg ccatcgccgc tatgcccgct gccgaagtca tcgctcccgc cgccgaaaag      180

aagaagagct ccgtgaaagc cgctggaatg aagtccattc tggtgtccga gaacaaaatg      240

tatatcacct ccttcggcaa aggcaattcc gctgtgctgg agtatgaggt ggacaacaac      300

gactacaatc agacccagct cagcagcaag gataactcca acatccagct gggcggcgtg      360

aatgaagtga atatcacctt cagcagcaag cacggatttg agtccggagt cgagattaac      420

acaagcaacc ctacccacag gtccggagaa agcagccctg tcagaggaga catgctggga      480

ctgaaaagcg agctggagaa gagattcttt ggaaagacct ttgatgacaa tatccacatc      540

cagctcattt acaacatcct ggatatcgag aaaatcctgg ccgtgtatgt gaccaacatc      600

gtgtacgctc tgaacaacat gctcggcgtc aagggcagcg agtcccacga cgactttatt      660

ggctatctgt ccaccaacaa tatttacgat gtcttcattg accccgacaa cagcagcctc      720

tccgacgaca aaaaagccaa cgtcaggaag agcctcagca aattcaacgc cctgctgaag      780

accaagaggc tcggatactt tggcctggag gaacccaaga ccaaggacaa cagagtgagc      840

caggcctata agaaaagggt gtaccacatg ctggccatcg tgggccagat cagacagtgc      900

gtgttccatg acaagtccgg cgccaagaga ttcgacctgt actccttcat taacaacatc      960

gaccctgagt acagggatac actggattac ctcgtggagg agaggctgaa gagcatcaac     1020

aaagacttta ttgaggacaa caaagtcaac atcagcctgc tgatcgatat gatgaagggc     1080

tacgaagctg acgacatcat caggctgtac tatgatttca ttgtcctgaa gagccagaag     1140

aacctgggat tctccattaa gaaactgaga gaaaagatgc tcgacgagta cggcttcagg     1200

ttcaaggaca agcagtatga cagcgtgaga tccaagatgt acaagctgat ggattttctc     1260

ctgttttgca actattacag gaacgacatc gccgccggcg aatccctggt caggaaactg     1320

agattcagca tgaccgacga cgagaaggaa ggcatctacg ccgacgaagc cgctaagctg     1380

tggggaaaat ttagaaatga cttcgagaac atcgctgacc acatgaacgg cgatgtgatc     1440

aaggagctcg gcaaggctga catggatttc gacgagaaga tcctggattc cgagaagaag     1500

aatgccagcg atctgctgta cttcagcaag atgatttaca tgctcacata ttttctcgat     1560

ggcaaggaga tcaacgatct cctgaccaca ctgatcagca agttcgacaa cattaaagag     1620

ttcctcaaaa ttatgaaatc cagcgccgtg gatgtcgagt gcgaactcac cgccggctac     1680

aagctcttca acgacagcca gaggatcacc aatgagctgt tcattgtgaa aaatatcgct     1740

agcatgagga aacccgccgc ctccgctaaa ctgacaatgt ttagagatgc cctcaccatc     1800

ctgggcatcg acgataagat cacagacgac agaattagcg gaatcctgaa gctcaaggaa     1860

aagggcaagg gaatccatgg cctcagaaat ttcattacca ataacgtgat cgaaagcagc     1920

aggttcgtgt atctgatcaa gtacgccaat gcccaaaaga tcagggaggt ggccaagaac     1980

gaaaaggtgg tgatgttcgt gctgggcggc attcctgaca cacagatcga aaggtactac     2040

aagagctgtg tggagttccc cgatatgaac tccagcctgg gcgtgaagag atccgaactg     2100

gctaggatga tcaagaatat tagcttcgac gacttcaaga acgtgaagca acaggccaaa     2160

ggaagggaga acgtcgccaa agagagagcc aaggccgtga tcggactcta cctgaccgtc     2220

atgtacctcc tcgtgaagaa cctggtgaac gtgaacgcta gatacgtcat cgccatccat     2280

tgcctcgaga gggacttcgg actgtacaag gagatcattc ccgagctggc cagcaaaaat     2340

ctcaagaacg attacagaat cctgagccaa accctgtgcg agctgtgtga caagtccccc     2400

aacctgtttc tgaagaagaa tgaaaggctg agaaagtgcg tcgaagtcga catcaacaac     2460

gctgacagct ccatgaccag gaaatacagg aactgtatcg cccatctgac cgtggtgagg     2520

gaactcaagg agtacatcgg agatatctgc accgtggact cctacttcag catttatcac     2580

tacgtgatgc agaggtgcat taccaagaga gaaaatgaca caaagcagga ggagaagatt     2640

aagtacgagg acgatctgct gaaaaaccac ggatacacca aggatttcgt caaggccctc     2700

aatagcccct tcggctacaa tatccctagg tttaaaaacc tgagcatcga gcagctgttt     2760

gacagaaatg aatacctgac agagaag                                         2787


<210>  121
<211>  2826
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized uncultured Ruminococcus sp. nCas1 with N-and C-terminal NLS tags

<400>  121
agccccaaga agaagagaaa ggtggaggcc agcgccaaga agaacaagat gaaacccagg       60

gagctgagag aggctcagaa gaaggctagg caactgaaag ccgccgagat caataacaat      120

gccgcccctg ccatcgccgc tatgcccgct gccgaagtca tcgctcccgc cgccgaaaag      180

aagaagagct ccgtgaaagc cgctggaatg aagtccattc tggtgtccga gaacaaaatg      240

tatatcacct ccttcggcaa aggcaattcc gctgtgctgg agtatgaggt ggacaacaac      300

gactacaatc agacccagct cagcagcaag gataactcca acatccagct gggcggcgtg      360

aatgaagtga atatcacctt cagcagcaag cacggatttg agtccggagt cgagattaac      420

acaagcaacc ctacccacag gtccggagaa agcagccctg tcagaggaga catgctggga      480

ctgaaaagcg agctggagaa gagattcttt ggaaagacct ttgatgacaa tatccacatc      540

cagctcattt acaacatcct ggatatcgag aaaatcctgg ccgtgtatgt gaccaacatc      600

gtgtacgctc tgaacaacat gctcggcgtc aagggcagcg agtcccacga cgactttatt      660

ggctatctgt ccaccaacaa tatttacgat gtcttcattg accccgacaa cagcagcctc      720

tccgacgaca aaaaagccaa cgtcaggaag agcctcagca aattcaacgc cctgctgaag      780

accaagaggc tcggatactt tggcctggag gaacccaaga ccaaggacaa cagagtgagc      840

caggcctata agaaaagggt gtaccacatg ctggccatcg tgggccagat cagacagtgc      900

gtgttccatg acaagtccgg cgccaagaga ttcgacctgt actccttcat taacaacatc      960

gaccctgagt acagggatac actggattac ctcgtggagg agaggctgaa gagcatcaac     1020

aaagacttta ttgaggacaa caaagtcaac atcagcctgc tgatcgatat gatgaagggc     1080

tacgaagctg acgacatcat caggctgtac tatgatttca ttgtcctgaa gagccagaag     1140

aacctgggat tctccattaa gaaactgaga gaaaagatgc tcgacgagta cggcttcagg     1200

ttcaaggaca agcagtatga cagcgtgaga tccaagatgt acaagctgat ggattttctc     1260

ctgttttgca actattacag gaacgacatc gccgccggcg aatccctggt caggaaactg     1320

agattcagca tgaccgacga cgagaaggaa ggcatctacg ccgacgaagc cgctaagctg     1380

tggggaaaat ttagaaatga cttcgagaac atcgctgacc acatgaacgg cgatgtgatc     1440

aaggagctcg gcaaggctga catggatttc gacgagaaga tcctggattc cgagaagaag     1500

aatgccagcg atctgctgta cttcagcaag atgatttaca tgctcacata ttttctcgat     1560

ggcaaggaga tcaacgatct cctgaccaca ctgatcagca agttcgacaa cattaaagag     1620

ttcctcaaaa ttatgaaatc cagcgccgtg gatgtcgagt gcgaactcac cgccggctac     1680

aagctcttca acgacagcca gaggatcacc aatgagctgt tcattgtgaa aaatatcgct     1740

agcatgagga aacccgccgc ctccgctaaa ctgacaatgt ttagagatgc cctcaccatc     1800

ctgggcatcg acgataagat cacagacgac agaattagcg gaatcctgaa gctcaaggaa     1860

aagggcaagg gaatccatgg cctcagaaat ttcattacca ataacgtgat cgaaagcagc     1920

aggttcgtgt atctgatcaa gtacgccaat gcccaaaaga tcagggaggt ggccaagaac     1980

gaaaaggtgg tgatgttcgt gctgggcggc attcctgaca cacagatcga aaggtactac     2040

aagagctgtg tggagttccc cgatatgaac tccagcctgg gcgtgaagag atccgaactg     2100

gctaggatga tcaagaatat tagcttcgac gacttcaaga acgtgaagca acaggccaaa     2160

ggaagggaga acgtcgccaa agagagagcc aaggccgtga tcggactcta cctgaccgtc     2220

atgtacctcc tcgtgaagaa cctggtgaac gtgaacgcta gatacgtcat cgccatccat     2280

tgcctcgaga gggacttcgg actgtacaag gagatcattc ccgagctggc cagcaaaaat     2340

ctcaagaacg attacagaat cctgagccaa accctgtgcg agctgtgtga caagtccccc     2400

aacctgtttc tgaagaagaa tgaaaggctg agaaagtgcg tcgaagtcga catcaacaac     2460

gctgacagct ccatgaccag gaaatacagg aactgtatcg cccatctgac cgtggtgagg     2520

gaactcaagg agtacatcgg agatatctgc accgtggact cctacttcag catttatcac     2580

tacgtgatgc agaggtgcat taccaagaga gaaaatgaca caaagcagga ggagaagatt     2640

aagtacgagg acgatctgct gaaaaaccac ggatacacca aggatttcgt caaggccctc     2700

aatagcccct tcggctacaa tatccctagg tttaaaaacc tgagcatcga gcagctgttt     2760

gacagaaatg aatacctgac agagaaggga tccggaccta agaaaaagag gaaggtggcg     2820

gccgct                                                                2826


<210>  122
<211>  2803
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized Ruminococcus flavefaciens FD1 nCas1

<400>  122
aagaaaaaaa tgagcctcag agagaagagg gaagccgaga aacaagccaa aaaagccgcc       60

tacagcgctg cctccaaaaa cacagatagc aaacctgctg agaagaaggc cgagacaccc      120

aagcctgctg agattatttc cgacaactcc agaaacaaaa ccgccgtcaa ggccgccggc      180

ctgaaatcca caattatctc cggcgataag ctgtacatga ccagcttcgg aaagggcaac      240

gccgccgtga tcgagcagaa aattgatatt aatgattact ccttctccgc catgaaggat      300

acccccagcc tggaagtgga caaggccgag agcaaggaga tctccttctc cagccaccac      360

ccttttgtca aaaatgataa actgaccacc tataatcccc tgtacggcgg aaaagataac      420

cccgaaaagc ccgtgggcag agatatgctc ggcctcaaag acaagctcga ggagaggtac      480

ttcggatgca ccttcaatga caacctgcac attcagatta tctataacat cctcgacatt      540

gagaaaattc tggccgtgca ctccgccaac attaccacag ctctggacca catggtggac      600

gaggacgatg agaagtacct caatagcgat tacattggct acatgaacac catcaacacc      660

tatgatgtgt tcatggaccc ctccaaaaat tcctccctct cccccaagga caggaagaac      720

attgataaca gcagggccaa gtttgagaag ctcctgtcca caaagaggct cggctacttt      780

ggctttgact acgatgccaa cggcaaggat aagaagaaaa acgaggagat caagaaaagg      840

ctctatcacc tgacagcctt tgccggccag ctcaggcagt ggtccttcca tagcgccggc      900

aattatccca gaacctggct ctacaagctc gatagcctgg acaaagagta tctcgacacc      960

ctggaccatt attttgataa gagattcaac gatattaatg acgatttcgt caccaagaac     1020

gccacaaacc tgtacatcct gaaggaggtc ttccccgagg ctaatttcaa ggatatcgcc     1080

gatctctact acgatttcat tgtcatcaaa agccataaga atatgggatt ttccatcaag     1140

aagctgaggg agaagatgct ggagtgcgat ggagctgata gaatcaagga acaggacatg     1200

gactccgtga ggagcaagct gtataagctg atcgattttt gcattttcaa atactaccac     1260

gagttccctg agctgagcga gaagaacgtc gacatcctca gggctgccgt gagcgatacc     1320

aaaaaggaca acctgtatag cgacgaggcc gctaggctct ggagcatctt caaggaaaag     1380

ttcctgggct tctgcgacaa gattgtggtg tgggtgaccg gcgagcacga gaaagacatc     1440

acctccgtga ttgacaagga cgcttacagg aacaggtcca acgtgagcta cttttccaag     1500

ctgatgtacg ccatgtgttt cttcctggat ggaaaggaaa ttaacgatct gctgaccaca     1560

ctgatcaaca aattcgacaa cattgccaac cagatcaaga ccgccaagga gctcggcatt     1620

aacaccgcct tcgtgaaaaa ctacgatttt ttcaaccaca gcgaaaagta cgtggacgag     1680

ctgaacattg tgaaaaacat cgccaggatg aaaaagccct ccagcaacgc caagaaggcc     1740

atgtaccatg acgccctgac aatcctgggc atccccgagg atatggacga gaaggccctg     1800

gatgaggagc tcgatctcat cctggaaaag aagaccgatc ccgtgaccgg aaagcccctc     1860

aaaggcaaaa atcccctgag gaattttatc gctaataatg tgattgagaa tagcaggttc     1920

atttacctga ttaaattttg caaccctgag aatgtcagga aaatcgtgaa caacacaaag     1980

gtgaccgagt tcgtgctcaa gaggatcccc gatgcccaga tcgagaggta ctacaagagc     2040

tgtaccgatt ccgagatgaa ccctcccaca gaaaagaaga tcaccgagct ggccggcaag     2100

ctgaaagata tgaattttgg aaacttcagg aacgtgaggc agtccgccaa ggaaaacatg     2160

gagaaagaga ggttcaaggc cgtcattggc ctgtacctca ccgtcgtcta cagagtggtc     2220

aaaaacctgg tggacgtcaa tagcaggtac atcatggcct tccatagcct ggagagagat     2280

tcccagctgt acaacgtgag cgtcgataat gattacctgg ccctcaccga caccctggtc     2340

aaggagggcg acaacagcag gtccaggtac ctggccggaa ataaaaggct gagggattgc     2400

gtgaagcaag acatcgacaa tgccaaaaag tggttcgtct ccgacaagta caactccatt     2460

acaaagtaca ggaacaacgt ggcccacctg accgccgtga gaaactgcgc cgagttcatc     2520

ggcgacatta ccaagatcga ctcctacttc gccctctacc actacctcat tcagagacag     2580

ctggctaagg gcctcgatca tgagaggtcc ggattcgaca ggaattaccc ccagtacgcc     2640

cctctgttca aatggcacac ctacgtgaag gatgtcgtca aggccctgaa cgcccccttc     2700

ggatacaata tccctaggtt caagaatctg agcatcgacg ccctctttga taggaatgaa     2760

atcaagaaga acgatggcga gaagaagtcc gacgactgag cct                       2803


<210>  123
<211>  2799
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized Ruminococcus flavefaciens FD1 nCas1 HEPN-/-

<400>  123
aagaaaaaaa tgagcctcag agagaagagg gaagccgaga aacaagccaa aaaagccgcc       60

tacagcgctg cctccaaaaa cacagatagc aaacctgctg agaagaaggc cgagacaccc      120

aagcctgctg agattatttc cgacaactcc agaaacaaaa ccgccgtcaa ggccgccggc      180

ctgaaatcca caattatctc cggcgataag ctgtacatga ccagcttcgg aaagggcaac      240

gccgccgtga tcgagcagaa aattgatatt aatgattact ccttctccgc catgaaggat      300

acccccagcc tggaagtgga caaggccgag agcaaggaga tctccttctc cagccaccac      360

ccttttgtca aaaatgataa actgaccacc tataatcccc tgtacggcgg aaaagataac      420

cccgaaaagc ccgtgggcag agatatgctc ggcctcaaag acaagctcga ggagaggtac      480

ttcggatgca ccttcaatga caacctgcac attcagatta tctataacat cctcgacatt      540

gagaaaattc tggccgtgca ctccgccaac attaccacag ctctggacca catggtggac      600

gaggacgatg agaagtacct caatagcgat tacattggct acatgaacac catcaacacc      660

tatgatgtgt tcatggaccc ctccaaaaat tcctccctct cccccaagga caggaagaac      720

attgataaca gcagggccaa gtttgagaag ctcctgtcca caaagaggct cggctacttt      780

ggctttgact acgatgccaa cggcaaggat aagaagaaaa acgaggagat caagaaaagg      840

ctctatcacc tgacagcctt tgccggccag ctcgcgcagt ggtccttcgc tagcgccggc      900

aattatccca gaacctggct ctacaagctc gatagcctgg acaaagagta tctcgacacc      960

ctggaccatt attttgataa gagattcaac gatattaatg acgatttcgt caccaagaac     1020

gccacaaacc tgtacatcct gaaggaggtc ttccccgagg ctaatttcaa ggatatcgcc     1080

gatctctact acgatttcat tgtcatcaaa agccataaga atatgggatt ttccatcaag     1140

aagctgaggg agaagatgct ggagtgcgat ggagctgata gaatcaagga acaggacatg     1200

gactccgtga ggagcaagct gtataagctg atcgattttt gcattttcaa atactaccac     1260

gagttccctg agctgagcga gaagaacgtc gacatcctca gggctgccgt gagcgatacc     1320

aaaaaggaca acctgtatag cgacgaggcc gctaggctct ggagcatctt caaggaaaag     1380

ttcctgggct tctgcgacaa gattgtggtg tgggtgaccg gcgagcacga gaaagacatc     1440

acctccgtga ttgacaagga cgcttacagg aacaggtcca acgtgagcta cttttccaag     1500

ctgatgtacg ccatgtgttt cttcctggat ggaaaggaaa ttaacgatct gctgaccaca     1560

ctgatcaaca aattcgacaa cattgccaac cagatcaaga ccgccaagga gctcggcatt     1620

aacaccgcct tcgtgaaaaa ctacgatttt ttcaaccaca gcgaaaagta cgtggacgag     1680

ctgaacattg tgaaaaacat cgccaggatg aaaaagccct ccagcaacgc caagaaggcc     1740

atgtaccatg acgccctgac aatcctgggc atccccgagg atatggacga gaaggccctg     1800

gatgaggagc tcgatctcat cctggaaaag aagaccgatc ccgtgaccgg aaagcccctc     1860

aaaggcaaaa atcccctgag gaattttatc gctaataatg tgattgagaa tagcaggttc     1920

atttacctga ttaaattttg caaccctgag aatgtcagga aaatcgtgaa caacacaaag     1980

gtgaccgagt tcgtgctcaa gaggatcccc gatgcccaga tcgagaggta ctacaagagc     2040

tgtaccgatt ccgagatgaa ccctcccaca gaaaagaaga tcaccgagct ggccggcaag     2100

ctgaaagata tgaattttgg aaacttcagg aacgtgaggc agtccgccaa ggaaaacatg     2160

gagaaagaga ggttcaaggc cgtcattggc ctgtacctca ccgtcgtcta cagagtggtc     2220

aaaaacctgg tggacgtcaa tagcaggtac atcatggcct tccatagcct ggagagagat     2280

tcccagctgt acaacgtgag cgtcgataat gattacctgg ccctcaccga caccctggtc     2340

aaggagggcg acaacagcag gtccaggtac ctggccggaa ataaaaggct gagggattgc     2400

gtgaagcaag acatcgacaa tgccaaaaag tggttcgtct ccgacaagta caactccatt     2460

acaaagtacg cgaacaacgt ggccgccctg accgccgtga gaaactgcgc cgagttcatc     2520

ggcgacatta ccaagatcga ctcctacttc gccctctacc actacctcat tcagagacag     2580

ctggctaagg gcctcgatca tgagaggtcc ggattcgaca ggaattaccc ccagtacgcc     2640

cctctgttca aatggcacac ctacgtgaag gatgtcgtca aggccctgaa cgcccccttc     2700

ggatacaata tccctaggtt caagaatctg agcatcgacg ccctctttga taggaatgaa     2760

atcaagaaga acgatggcga gaagaagtcc gacgactga                            2799


<210>  124
<211>  2757
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Ruminococcus bicirculans nCas1 sequence

<400>  124
atggcaaaaa agaataaaat gaagcctaga gagctgcgtg aggctcagaa aaaagccaga       60

cagctcaaag cggctgagat aaataataac gctgttcctg caatcgctgc catgcctgct      120

gcagaggctg ctgcacctgc ggcagagaag aaaaaatcct ccgtaaaggc ggcaggaatg      180

aagtctattc ttgtcagtga aaataaaatg tacataacct ctttcggcaa gggcaattct      240

gcggtgcttg aatatgaggt ggataataat gactacaaca aaactcagct ttcctcaaag      300

gacaacagta atatcgagct ctgtgatgta ggcaaagtaa acatcacttt ttcgagcaga      360

cgtggctttg agagcggtgt ggagataaac acttcaaacc ctactcacag aagcggtgaa      420

agctcgtctg taagagggga tatgctgggg cttaaatcgg agcttgaaaa gcgctttttc      480

ggcaagaatt ttgatgataa tatacatatc cagcttattt acaacattct ggatatcgaa      540

aagatacttg cagtgtatgt gacgaatatc gtttatgcac tgaacaatat gcttggggaa      600

ggcgatgaga gcaattacga tttcatgggg tatctttcca catttaacac ttataaagtt      660

tttactaatc ctaatggcag cactttatcc gacgataaga aagagaatat cagaaaaagt      720

cttagcaaat tcaatgccct gctgaaaact aagcgtcttg gctatttcgg ccttgaagag      780

ccaaagacaa aggatacaag agcttcggaa gcatacaaaa agcgtgttta tcatatgctt      840

gcaattgtgg ggcagataag acagtgtgtt tttcatgata aatcgggtgc aaaaagattt      900

gacctttaca gttttattaa caatattgat cccgaataca gagaaaccct tgactatctt      960

gtagatgaga gatttgattc tataaataag ggctttatcc agggcaacaa ggtcaatatc     1020

agcttgctta ttgatatgat gaaaggctat gaggctgatg atatcatacg cctttattac     1080

gatttcattg tgcttaaatc tcagaaaaat ctcggttttt ctatcaaaaa gcttcgtgag     1140

aaaatgctgg acgaatacgg cttcagattt aaggacaagc aatatgactc tgtgcgctca     1200

aagatgtaca agcttatgga ttttctgctt ttctgcaact actacagaaa tgacattgcc     1260

gcaggcgaat ctcttgtgcg caaactgcgt ttttcaatga ccgatgatga aaaagagggg     1320

atatatgctg atgaagcggc aaagctttgg ggcaaattca ggaatgattt tgaaaatatc     1380

gccgaccaca tgaacggtga cgttatcaag gagcttggca aggctgacat ggattttgat     1440

gagaaaattc ttgacagcga aaagaagaat gcgtctgacc ttttgtattt ctccaaaatg     1500

atatatatgc tcacatattt tcttgacggc aaggagataa acgaccttct tacaacgctt     1560

atcagcaagt ttgataacat caaggagttt ttgaagataa tgaaaagctc tgctgttgat     1620

gttgagtgtg aacttacggc gggctacaag ctgttcaatg acagccagag gataaccaac     1680

gagcttttta tcgtaaagaa cattgcttcc atgagaaagc ctgcggcttc ggcgaagctt     1740

acgatgttcc gtgacgcact gactatactc ggtatagacg acaagatcac ggacgatagg     1800

ataagcgaga ttctaaaact taaagaaaaa ggcaagggca tacatggcct gagaaatttc     1860

ataacaaaca atgttatcga gtcctctcgg tttgtatacc ttatcaagta tgcgaacgct     1920

cagaagataa gagaagtggc taagaatgag aaagttgtca tgtttgttct tgggggtatc     1980

cctgacacgc agatagagcg ttattacaag agttgtgtgg aatttcctga catgaacagt     2040

tctttgggag taaagcgcag tgagcttgcg agaatgataa agaacatcag ctttgatgat     2100

ttcaaaaatg tgaaacagca ggcaaagggc agagaaaacg tggctaagga gagggcaaag     2160

gctgttatcg ggctttatct tacggtcatg tatctgctgg tgaaaaatct tgtgaatgtc     2220

aatgcaaggt atgttattgc gatacactgc cttgaacgtg attttgggct gtataaggag     2280

ataattcctg agttggcttc aaagaacttg aaaaatgact acaggatact ttcacagacg     2340

ctttgtgaac tttgtgataa gtcgccgaat ttgttcttga aaaagaacga gcggctgcgc     2400

aagtgcgttg aagttgatat caataatgca gacagcagca tgacaagaaa ataccgcaac     2460

tgtattgctc atcttactgt agttcgtgaa ctgaaagaat acataggaga tatttgtaca     2520

gtggattctt acttctccat ttatcattat gttatgcagc gctgtatcac gaaaagggaa     2580

aatgacacaa agcaagaaga gaaaataaag tatgaggacg atcttttaaa aaatcacggc     2640

tatacgaaag actttgtaaa ggctctcaac tcgccgtttg gatacaacat tccgaggttt     2700

aaaaatcttt caattgagca gttgtttgac agaaatgaat atcttactga aaagtag        2757


<210>  125
<211>  2865
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Eubacterium siraeum nCas1 sequence

<400>  125
atgggtaaga aaatacacgc acgagatctc agagaacaaa gaaagaccga tagaacggaa       60

aaatttgcag atcagaacaa aaaacgtgaa gcagagaggg cagttccgaa aaaagacgca      120

gccgtttctg taaaatcagt ttcttctgtt tcatcaaaaa aagacaatgt aacaaaatct      180

atggctaaag ccgcaggcgt gaagtcggtt tttgctgtag gaaatactgt ttatatgact      240

tcattcggca gaggaaacga tgctgtactt gagcagaaaa tagtcgatac atcgcacgaa      300

ccgctgaata ttgacgatcc tgcatatcag ttgaacgttg tcacaatgaa cggttattcg      360

gttaccggtc acagaggtga aacggtatct gccgtaacgg ataatccgct gcgccgtttt      420

aacggaagaa agaaagatga accggaacag tctgtgccta cggatatgct gtgcctgaaa      480

ccgactcttg aaaagaaatt cttcggcaaa gaattcgatg ataatataca tatccagctt      540

atttacaata ttcttgacat tgaaaaaata ctggcggttt attcgaccaa cgctatttac      600

gcattgaata atatgagtgc tgacgaaaat atcgaaaaca gcgatttctt catgaaacgt      660

accaccgatg aaacctttga cgattttgaa aagaaaaagg agagtacaaa cagtcgagag      720

aaagccgatt ttgacgcatt tgaaaaattc atcggcaatt acaggctggc ttattttgcc      780

gatgcatttt atgtaaataa aaagaatccc aaaggtaaag caaaaaatgt tctgcgtgag      840

gataaagaac tttactccgt gctcactctg atcggtaaac tgcgtcattg gtgtgttcac      900

agtgaggagg gcagagcaga attctggctg tataagctcg atgaacttaa agatgatttc      960

aaaaatgtac tcgacgttgt ttataaccgt cctgttgaag aaataaacaa ccgctttata     1020

gaaaacaata aggtaaacat acagatactg ggctcggtat acaagaacac cgatattgcc     1080

gaacttgtaa ggtcatatta cgaatttctt atcacaaaga agtataaaaa tatgggcttt     1140

tcaataaaga agctccgtga gagtatgctc gaaggtaaag gttacgccga taaagaatat     1200

gattctgtaa ggaataagct gtatcagatg acggatttca tcttatacac aggatatatc     1260

aacgaagaca gcgatagagc cgacgatctt gtgaacactt tgagaagttc gctcaaagag     1320

gatgataaga caaccgtata ttgcaaggaa gcggattatc tgtggaaaaa ataccgtgaa     1380

tccataagag aggttgccga tgcgcttgat ggcgataaca ttaaaaagct gagcaaatcg     1440

aatattgaaa ttcaggaaga caagctgaga aaatgtttta tcagctatgc cgacagcgta     1500

tcggaattta ccaagcttat ttatctgctg acaagatttt taagcggtaa ggagatcaac     1560

gatcttgtca caacgctgat aaacaagttt gacaatatca gaagcttcct tgaaataatg     1620

gacgagcttg ggcttgacag gaccttcacc gccgagtaca gcttctttga aggcagtaca     1680

aagtatcttg ccgagcttgt cgagcttaac agctttgtga aatcgtgttc gtttgatata     1740

aacgcaaaaa gaacaatgta tcgcgatgcg ctggatattc tcggcattga atcggataag     1800

accgaagaag atattgagaa gatgatcgat aatatccttc agatcgacgc aaacggtgat     1860

aaaaagctca agaaaaacaa cggtctgaga aatttcattg caagtaacgt tatagattca     1920

aaccgattca agtaccttgt gcggtacgga aatccaaaga agattcgtga aacggcaaaa     1980

tgcaagcccg ctgtaaggtt tgtgctgaat gagatcccgg acgcacagat cgaaagatat     2040

tatgaggctt gttgcccaaa aaatacagct ttatgctctg caaataagag acgtgagaaa     2100

ctggctgata tgatagctga aataaagttt gagaattttt cggatgccgg caattatcag     2160

aaagcaaatg tcacatcaag aacgtctgaa gctgaaatca agcggaagaa tcaggctata     2220

atccgtcttt atcttaccgt tatgtacatt atgctgaaga accttgtaaa tgtgaacgcc     2280

agatacgtta tcgctttcca ttgcgttgaa agggatacga agctgtatgc ggaaagcggt     2340

ctggaagtcg gtaatataga aaaaaacaag acaaatctta ctatggctgt aatgggagtc     2400

aagctcgaaa acggaatcat aaaaacggaa tttgacaaga gctttgcaga aaatgccgca     2460

aacagatatc tcaggaatgc acgctggtac aagctgatac tggataattt aaagaagtcg     2520

gaaagagcgg ttgtcaatga gttcagaaat actgtctgcc atctgaatgc gataaggaat     2580

atcaatatca atatcaagga aataaaagag gtcgagaact actttgctct gtaccactac     2640

ctcattcaga aacatctcga aaatcgtttt gccgataaaa aagtagaaag agacaccggc     2700

gattttataa gcaagctcga agaacacaag acttactgca aggactttgt aaaagcatat     2760

tgtacgcctt tcggatataa ccttgtgaga tataaaaacc ttacgataga cgggctgttt     2820

gataagaatt accccggaaa agacgattct gatgaacaga aataa                     2865


<210>  126
<211>  2799
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Ruminococcus flavefaciens FD1 nCas1 sequence

<400>  126
atgaaaaaga aaatgtctct ccgtgaaaag cgtgaagccg agaaacaggc taaaaaagct       60

gcatattcag cagcttcaaa aaatacagat tctaagcctg cggaaaagaa agcagaaact      120

ccaaagcctg cggagattat ttccgataat tccagaaata agaccgctgt aaaggcggct      180

ggtctgaaat caacaattat cagcggcgat aagctgtata tgacatcttt cggcaagggt      240

aacgctgctg ttattgagca gaaaatagat atcaatgatt attctttttc agctatgaaa      300

gatactccgt cgcttgaagt tgataaagca gaatcaaaag agatctcttt ttcaagtcac      360

catccttttg taaagaatga taagctgaca acatataacc ctttatacgg cggcaaggat      420

aaccccgaaa agcctgtcgg cagggatatg ctcggcttaa aagataagct tgaagaacgc      480

tatttcggat gtacattcaa tgataatctt cacatccaga ttatctataa catacttgac      540

atcgagaaga ttttagctgt tcattctgca aatatcacaa ctgcgcttga ccacatggtt      600

gatgaagacg atgaaaaata tcttaacagc gattatatcg gctacatgaa taccataaat      660

acatatgacg tgtttatgga tccttcaaag aattcttcat taagccctaa agatagaaag      720

aatattgaca acagccgtgc aaaatttgag aaactgcttt caactaagcg ccttggctat      780

tttggatttg actatgatgc aaacggtaag gacaagaaaa agaacgagga aataaaaaag      840

cgtttatatc atctcacagc ttttgcaggt cagctccgtc agtggagttt tcatagtgct      900

ggcaattatc cgagaacatg gctttacaag ctcgattcac tggataagga atatcttgat      960

actcttgacc attacttcga taaacgtttt aacgatataa acgatgattt cgtaactaag     1020

aatgctacca atctctatat tctgaaagaa gtatttcccg aagcaaactt caaggatatt     1080

gccgatcttt attacgattt catagttata aagtcgcaca aaaatatggg attctccata     1140

aaaaagctga gggagaagat gcttgaatgt gatggtgcag acaggataaa agaacaggat     1200

atggactctg ttcgctcaaa gctgtataag ctcatagact tttgcatttt caagtattat     1260

cacgaatttc ctgaacttag tgaaaagaat gtggatatac tcagagcggc tgtatccgat     1320

acaaaaaaag ataaccttta ttctgatgag gctgcacgtt tatggagcat atttaaagaa     1380

aaattcctcg gcttctgtga taagatagtt gtatgggtaa caggagagca tgagaaagat     1440

atcacatccg ttattgataa ggatgcttac aggaacagga gcaatgtttc atatttctca     1500

aagctgatgt atgcaatgtg ctttttcctt gacggaaaag agataaatga ccttctcact     1560

actcttatca acaaattcga taatatcgct aaccagataa aaacagccaa agaacttggc     1620

attaatactg cttttgtaaa gaattacgat ttcttcaatc acagcgagaa atatgtcgat     1680

gaactgaaca tcgtcaagaa tattgcaaga atgaagaagc cttcaagtaa tgccaaaaaa     1740

gctatgtatc atgatgcgct tactattctc ggaatacctg aggatatgga tgaaaaagct     1800

cttgatgagg aactggattt aattcttgaa aaaaagacag acccagtaac tggcaagcca     1860

ctgaaaggta agaatccttt acgtaatttt atcgcaaaca atgtgataga gaattcaaga     1920

ttcatatatc ttatcaagtt ctgcaatcct gagaatgtac gtaaaatcgt gaataataca     1980

aaggtcactg agtttgtgtt aaagcgtatt cccgatgctc agatcgaacg ctattataag     2040

tcgtgtacag attctgaaat gaatccgcct actgaaaaga agatcaccga acttgctggt     2100

aagttaaagg atatgaactt tggcaacttc cgaaatgtga gacagtctgc taaagagaat     2160

atggagaagg agcgcttcaa agctgttata gggctttatc tcacggtagt atatcgtgtt     2220

gtcaagaatc ttgttgatgt aaactcacga tatatcatgg cttttcattc gcttgaacgt     2280

gattcacaac tgtataacgt atctgttgat aatgattatc ttgcacttac cgatactctt     2340

gttaaggagg gagataattc cagaagcaga tatcttgcag gcaacaagcg tctgagagat     2400

tgtgtgaagc aggatatcga taatgcaaaa aagtggtttg ttagtgataa gtacaatagc     2460

ataaccaagt acaggaataa cgttgcccat cttaccgctg tacgtaactg cgctgaattc     2520

atcggagata taacgaagat agactcctat tttgcattgt atcattatct cattcagaga     2580

cagcttgcga aaggtcttga ccatgagcga agtggctttg acagaaacta tccacagtat     2640

gcaccgctgt ttaagtggca tacgtatgta aaggatgttg tcaaggctct gaatgctcca     2700

tttggctaca atatccctcg tttcaagaat ctcagcatag atgcactttt tgaccgcaac     2760

gaaataaaga agaatgacgg cgagaaaaaa tccgatgat                            2799


<210>  127
<211>  2835
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Ruminococcus albus nCas1 sequence

<400>  127
atggcaaaaa aatcgaaagg tatgagcctt agagaaaaac gtgaacttga aaagcagaaa       60

aggatacaaa aggcagctgt gaattcagtt aatgatacac ctgaaaaaac agaagaagca      120

aatgtcgtat ctgtaaatgt caggacatcg gctgagaata agcatagtaa aaaatctgct      180

gccaaagctt tgggactgaa atccgggctg gttatcggtg atgagctgta ccttacttca      240

ttcggcagag gtaacgaagc aaagcttgaa aagaagatat ccggtgacac tgtcgaaaaa      300

cttggcattg gtgcttttga agtcgccgaa cgtgacgaat caacgcttac cctcgaaagt      360

ggcaggataa aggacaagac cgccagaccc aaagacccca gacatataac cgtcgataca      420

caaggtaaat tcaaggaaga tatgcttggg atacgcagtg tactggagaa aaagatattt      480

ggcaaaacat ttgatgataa tatccatgtt cagcttgcgt acaatatcct ggatgtcgaa      540

aagataatgg cacagtatgt cagcgatatc gtatatatgc tgcataatac tgataaaaca      600

gaaagaaacg ataatcttat ggggtatatg agcatcagga atacctataa gacattttgt      660

gatacgtcaa atcttcccga tgatacaaaa caaaaagttg aaaatcagaa gagagagttt      720

gacaagatca taaaaagcgg cagacttggg tatttcggcg aagcttttat ggtaaacagc      780

ggcaatagta ccaagcttag acccgagaaa gagatatatc atatctttgc gcttatggcg      840

agcctgaggc agagttactt tcacggatat gtaaaagata ccgattatca gggaaccaca      900

tgggcatata ctcttgagga caagctgaaa ggtccgagcc atgagttcag ggaaaccatt      960

gataagatat ttgatgaggg attcagcaag atcagcaagg actttggcaa gatgaacaag     1020

gtcaaccttc agatacttga acagatgatt ggtgaactgt atggcagtat agaacgacaa     1080

aacctcactt gcgattacta tgacttcatt caactgaaaa agcataagta tcttggattt     1140

tctataaagc gtcttagaga gaccatgctt gaaacaacac cggctgaatg ttataaagct     1200

gaatgctata acagcgagcg tcaaaagctg tataagctga tagatttcct gatatatgat     1260

ctttactata accgtaagcc tgcacgcatc gaagaaatcg tggacaagct gagggaatct     1320

gtgaacgacg aagagaaaga atccatatat tcagttgagg cgaagtatgt ctatgaatca     1380

cttagcaaag ttctggataa atcgctgaaa aacagtgtgt ctggtgaaac gataaaggat     1440

ctccaaaaga gatatgatga cgaaacagca aacaggatct gggatatctc acagcacagt     1500

ataagtggaa atgtcaactg tttctgcaag ctaatttata ttatgaccct gatgcttgac     1560

ggcaaggaga taaatgatct gctgacaacg ctggtaaaca agttcgataa catagcatca     1620

tttatagatg ttatggacga acttggcttg gagcatagtt ttacagataa ctataaaatg     1680

tttgccgaca gcaaggctat atgccttgat ctgcagttca taaacagttt tgcacgtatg     1740

tcaaagatcg atgatgagaa gtcaaaaaga cagcttttcc gtgatgcgct tgtcatactg     1800

gatatcggta ataaagatga gacttggata aataattatc tggattctga tattttcaaa     1860

ctggacaaag aaggtaacaa gttaaagggc gcaaggcatg atttcaggaa ctttatagcc     1920

aataatgtta taaagtcatc acgtttcaaa tacctagtaa aatacagcag tgccgatggt     1980

atgataaagc tgaaaacgaa tgaaaagctg ataggctttg ttctggataa gcttccagaa     2040

acgcagatag accgctacta tgaatcatgc ggacttgaca atgcggtagt agataagaaa     2100

gtcaggatag aaaagctatc ggggcttatc agagatatga agttcgatga tttcagcggt     2160

gtcaaaacct caaacaaagc aggagataat gacaaacagg ataaggcgaa atatcaggcg     2220

ataataagcc tgtacctcat ggtgctgtat cagatagtca agaacatgat atatgtcaac     2280

tcacgttatg ttatcgcttt ccattgtctt gaacgtgact ttggtatgta tggaaaagat     2340

tttggaaagt attatcaagg ctgccgaaaa cttacagatc attttattga agaaaagtac     2400

atgaaagagg gtaaacttgg ctgcaataaa aaagtcggca gatatctgaa aaataatatt     2460

tcctgctgca ctgatggact gataaatacc taccgtaatc aggttgatca ctttgcagtg     2520

gtaaggaaga taggcaacta tgcggcatat atcaagagta tcggttcgtg gtttgaactt     2580

tatcactatg taatacagag gatagttttt gacgaataca gatttgcact taacaacact     2640

gaaagcaact ataagaacag catcatcaag caccatacct actgtaagga tatggtcaag     2700

gcactgaaca cacctttcgg ttatgacctg ccgagataca agaatctttc tatcggtgat     2760

ctgtttgatc gcaataatta tctgaataaa acaaaagagt caatagatgc aaatagctct     2820

attgacagtc agtga                                                      2835


<210>  128
<211>  2904
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Ruminococcus flavefaciens XPD nCas1 sequence

<400>  128
atgatcgaaa agaagaagtc atttgcaaag ggcatgggag taaaatcaac acttgtatcc       60

ggttcaaagg tatacatgac gacgttcgca gaaggaagcg atgccagact tgaaaagatc      120

gttgaaggcg attctatcag atctgtcaac gaaggagaag cgttctcagc tgaaatggct      180

gataagaatg caggctacaa gatcggtaac gcaaagttca gccacccaaa gggctatgct      240

gtagttgcaa acaacccctt atacaccgga ccggtacagc aggatatgct cggtctgaag      300

gaaacgcttg aaaagagata ttttggagag tctgccgacg gaaatgataa tatctgtatt      360

caggtcatcc ataatatcct cgatatcgaa aagatcctcg ctgaatatat aaccaatgct      420

gcttatgcgg taaacaatat ttccggtctt gataaggata tcatcggttt tggtaagttc      480

agtacggtct atacttatga tgagttcaag gatcctgaac atcacagagc agctttcaac      540

aataacgata agttaattaa tgccatcaag gcacagtatg atgaatttga caatttcctt      600

gataatcctc gtctcggcta ctttggacag gcttttttca gtaaggaagg cagaaattac      660

attatcaatt acggcaacga gtgttatgat attcttgctt tactcagcgg attgcgtcac      720

tgggtagtac ataataatga ggaagaatca aggatttccc gtacatggct ttataatctc      780

gacaagaatc ttgacaacga atatatctct actctcaatt atctgtatga tagaattaca      840

aacgaattaa caaattcctt ctcaaagaat agtgcagcca acgtaaacta tatcgctgaa      900

acccttggta ttaatcctgc tgaatttgca gagcagtatt tcagattcag tatcatgaag      960

gaacagaaga atctcggttt caatattact aagctgagag aagtaatgct tgacagaaag     1020

gatatgtctg agatccgtaa aaatcataag gtctttgatt caatccgtac taaggtctat     1080

actatgatgg atttcgttat ctacagatat tacattgaag aggatgcaaa ggttgctgct     1140

gccaacaagt ctctgccgga taacgaaaaa agcctcagtg aaaaggatat ctttgttata     1200

aatctcagag gaagctttaa cgatgatcag aaggatgccc tttattatga tgaggccaat     1260

cgtatttgga gaaagctcga aaacattatg cacaatatca aggaattcag aggcaataag     1320

acacgtgaat acaagaagaa ggatgctcca agactcccca gaattcttcc tgccggaagg     1380

gatgtttccg cgttctcaaa gttgatgtac gctcttacca tgttccttga tggtaaggag     1440

atcaatgatc ttctcaccac gctcatcaat aagttcgata acatccagag tttcctcaag     1500

gtaatgcctc ttatcggagt gaatgcaaag tttgttgagg aatatgcctt cttcaaggac     1560

agcgcaaaga ttgctgacga actcaggctg attaagagct ttgccagaat gggagaacct     1620

atcgcagatg caagacgtgc tatgtatatc gatgctatca ggattctcgg aacaaacctc     1680

agctatgatg agcttaaggc ccttgccgat actttttcgc ttgatgaaaa cggcaacaag     1740

cttaagaagg gcaagcacgg catgagaaac ttcatcatta ataatgtaat cagtaacaag     1800

cgcttccatt atctcattcg ttacggtgat cctgcacatc tccatgagat cgccaagaat     1860

gaagctgttg taaagttcgt cctcggcagg atagctgata tccagaagaa gcagggacag     1920

aacggaaaga atcagatcga caggtactat gagacctgta tcggcaagga caagggcaag     1980

tctgtctccg aaaaggttga tgccctcaca aagattatca ccggtatgaa ctacgatcag     2040

ttcgataaga agagaagcgt tattgaggat actggaagag aaaacgctga gagagaaaag     2100

ttcaagaaga tcatcagcct ctatcttact gtcatttatc acatccttaa gaatattgtt     2160

aatatcaatg cgcgttacgt tatcggcttc cattgcgttg agcgtgatgc acagctctat     2220

aaggaaaagg gctatgatat caacctcaag aagctcgaag aaaaggggtt ttcatcagtc     2280

acaaagctgt gtgcaggtat tgatgagact gctcctgaca agcgtaagga tgttgaaaag     2340

gaaatggctg agcgtgcaaa ggaatctatc gatagccttg aatctgcaaa tcctaagctt     2400

tacgcaaact atatcaagta ttctgacgag aagaaggctg aggaatttac tagacagatc     2460

aaccgtgaga aggcaaagac cgctctgaat gcatatctca gaaatactaa gtggaatgtg     2520

ataatcaggg aagatcttct tagaatcgat aataagacat gtacgctctt tagaaataag     2580

gccgttcatc ttgaagttgc aagatatgtt catgcatata tcaacgatat tgccgaagta     2640

aacagctatt tccagcttta tcattacatc atgcagagaa tcatcatgaa cgaaagatat     2700

gaaaagtctt ctggaaaggt aagcgaatac ttcgatgctg tgaacgatga aaagaagtac     2760

aacgacaggc ttctgaagct gttgtgcgtt ccatttggtt actgcatccc gagattcaag     2820

aatctctcca ttgaagcttt gttcgacagg aacgaagcag ctaagtttga caaggaaaag     2880

aagaaagtat caggtaattc atag                                            2904


<210>  129
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Consensus DR

<400>  129
gaactacacc cgtgcaaaaa tgcaggggtc taaaac                                 36


<210>  130
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Consensus DR

<400>  130
ctactacact ggtgcaaatt tgcactagtc taaaac                                 36


<210>  131
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Consensus DR

<400>  131
caaguaaacc ccuaccaacu ggucgggguu ugaaac                                 36


<210>  132
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Consensus DR

<400>  132
cuacuacacu ggugcgaauu ugcacuaguc uaaaac                                 36


<210>  133
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Consensus DR

<400>  133
gaacuauagu agugugaauu uacacuacuc uaaaac                                 36


<210>  134
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Consensus DR

<400>  134
cuacuauacu agugugauuu uacacuaguc uaaaac                                 36


<210>  135
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Consensus DR

<400>  135
gaccaacacc ucugcaaaac ugcagggguc uaaaac                                 36


<210>  136
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Consensus DR

<400>  136
gcacuacacc ccccugaaac augagggguc uaaaac                                 36


<210>  137
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Consensus DR

<400>  137
gcactacacc cccctgaaac atgaggggtc taaaac                                 36


<210>  138
<211>  966
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  50% consensus sequence for 7 full-length nCas1 orthologues


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (69)..(70)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (74)..(76)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (94)..(95)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (97)..(108)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (110)..(135)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (139)..(147)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (149)..(150)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (157)..(158)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (162)..(162)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (191)..(192)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (201)..(209)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (211)..(211)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (213)..(214)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (216)..(217)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (220)..(221)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (225)..(225)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (227)..(228)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (230)..(242)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (244)..(249)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (251)..(251)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (253)..(257)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (264)..(264)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (267)..(270)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (273)..(280)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (283)..(283)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (285)..(285)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (290)..(292)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (296)..(298)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (300)..(310)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (314)..(314)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (316)..(318)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (320)..(321)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (323)..(325)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (329)..(331)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (333)..(337)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (340)..(341)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (343)..(345)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (350)..(352)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (354)..(357)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (359)..(368)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (373)..(375)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (377)..(378)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (391)..(391)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (394)..(397)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (399)..(404)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (411)..(411)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (415)..(415)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (417)..(417)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (420)..(420)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (423)..(424)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (426)..(427)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (429)..(433)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (435)..(436)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (438)..(439)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (442)..(442)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (444)..(445)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (447)..(447)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (450)..(452)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (454)..(455)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (458)..(459)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (462)..(477)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (479)..(481)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (483)..(485)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (487)..(487)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (489)..(489)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (491)..(506)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (509)..(510)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (517)..(517)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (520)..(520)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (542)..(542)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (546)..(546)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (549)..(549)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (554)..(556)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (558)..(560)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (562)..(563)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (565)..(566)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (568)..(569)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (571)..(572)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (575)..(577)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (580)..(580)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (584)..(584)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (587)..(589)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (593)..(593)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (600)..(600)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (605)..(612)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (614)..(616)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (618)..(624)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (626)..(629)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (631)..(632)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (634)..(636)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (648)..(648)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (650)..(650)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (653)..(653)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (656)..(656)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (659)..(659)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (662)..(664)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (666)..(667)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (669)..(669)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (673)..(675)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (679)..(680)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (684)..(684)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (694)..(696)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (698)..(706)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (708)..(709)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (711)..(713)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (715)..(718)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (720)..(720)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (723)..(723)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (726)..(726)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (728)..(733)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (735)..(738)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (742)..(742)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (745)..(745)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (753)..(753)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (755)..(756)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (778)..(779)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (782)..(797)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (800)..(812)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (816)..(852)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (856)..(856)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (858)..(858)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (861)..(861)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (863)..(863)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (865)..(868)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (871)..(871)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (874)..(875)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (877)..(877)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (886)..(887)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (890)..(890)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (892)..(897)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (899)..(912)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (914)..(914)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (917)..(917)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (920)..(920)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (926)..(926)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (932)..(932)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (941)..(942)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (949)..(954)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (956)..(957)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (959)..(963)
<223>  Xaa can be any naturally occurring amino acid

<400>  138

Met Xaa Xaa Xaa Lys Lys Lys Met Ser Leu Arg Glu Xaa Arg Glu Ala 
1               5                   10                  15      


Glu Lys Gln Ala Arg Xaa Xaa Lys Xaa Ala Ala Ala Ser Lys Asn Xaa 
            20                  25                  30          


Xaa Ala Val Pro Ala Lys Xaa Xaa Ala Ala Xaa Xaa Pro Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys Ser Xaa Ala Lys Ala Ala 
    50                  55                  60                  


Gly Leu Lys Ser Xaa Xaa Val Xaa Gly Xaa Xaa Xaa Tyr Met Thr Ser 
65                  70                  75                  80  


Phe Gly Xaa Gly Asn Xaa Ala Xaa Leu Glu Lys Lys Ile Xaa Xaa Asx 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Pro Leu Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Val Xaa Xaa Asp Met Leu Gly Leu Lys Xaa Xaa Leu Glu 
145                 150                 155                 160 


Lys Xaa Tyr Phe Gly Lys Xaa Phe Asp Asp Asn Ile His Ile Gln Leu 
                165                 170                 175     


Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Xaa Xaa 
            180                 185                 190         


Asn Ile Val Tyr Ala Leu Asn Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Asn Xaa Asp Xaa Xaa Gly Xaa Xaa Ser Thr Xaa Xaa Thr Tyr Asp 
    210                 215                 220                 


Xaa Phe Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Lys Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Arg Leu Gly Tyr Phe Gly Xaa Ala Phe Xaa Xaa Xaa Xaa Lys Asx 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Glu Xaa Tyr Xaa Ile Leu Ala 
        275                 280                 285             


Leu Xaa Xaa Xaa Leu Arg Gln Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Trp Leu Tyr Xaa Leu Xaa Xaa Xaa Leu Xaa 
305                 310                 315                 320 


Xaa Glu Xaa Xaa Xaa Thr Leu Asp Xaa Xaa Xaa Asp Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Ile Asn Xaa Xaa Phe Xaa Xaa Xaa Asn Lys Val Asn Xaa Xaa Xaa 
            340                 345                 350         


Leu Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Tyr Tyr Asp Phe Xaa Xaa Xaa Lys Xaa Xaa Lys Asn Leu Gly Phe Ser 
    370                 375                 380                 


Ile Lys Lys Leu Arg Glu Xaa Met Leu Xaa Xaa Xaa Xaa Ala Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Glx Tyr Asp Ser Val Arg Xaa Lys Leu Tyr Xaa Leu 
                405                 410                 415     


Xaa Asp Phe Xaa Ile Tyr Xaa Xaa Tyr Xaa Xaa Glu Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Glu Xaa Xaa Val Xaa Xaa Leu Arg Xaa Ser Xaa Xaa Asp Xaa Glu 
        435                 440                 445             


Lys Xaa Xaa Xaa Tyr Xaa Xaa Glu Ala Xaa Xaa Leu Trp Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa 
465                 470                 475                 480 


Xaa Lys Xaa Xaa Xaa Lys Xaa Asx Xaa Asp Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asx Val Xaa Xaa Phe Ser 
            500                 505                 510         


Lys Leu Ile Tyr Xaa Leu Thr Xaa Phe Leu Asp Gly Lys Glu Ile Asn 
        515                 520                 525             


Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Xaa Ser Phe 
    530                 535                 540                 


Leu Xaa Val Met Xaa Glu Leu Gly Leu Xaa Xaa Xaa Phe Xaa Xaa Xaa 
545                 550                 555                 560 


Tyr Xaa Xaa Phe Xaa Xaa Ser Xaa Xaa Ile Xaa Xaa Glu Leu Xaa Xaa 
                565                 570                 575     


Xaa Lys Asn Xaa Ala Arg Met Xaa Lys Pro Xaa Xaa Xaa Ala Lys Arg 
            580                 585                 590         


Xaa Met Tyr Arg Asp Ala Leu Xaa Ile Leu Gly Ile Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Ile Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Asp Xaa Xaa Xaa Xaa Lys Xaa Xaa Lys Xaa Xaa Xaa Gly Leu Arg Asn 
625                 630                 635                 640 


Phe Ile Ala Asn Asn Val Ile Xaa Ser Xaa Arg Phe Xaa Tyr Leu Xaa 
                645                 650                 655     


Arg Tyr Xaa Asn Pro Xaa Xaa Xaa Arg Xaa Xaa Ala Xaa Asn Glu Lys 
            660                 665                 670         


Xaa Xaa Xaa Phe Val Leu Xaa Xaa Ile Pro Asp Xaa Gln Ile Glu Arg 
        675                 680                 685             


Tyr Tyr Glu Ser Cys Xaa Xaa Xaa Asx Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Ile Xaa Xaa Leu Xaa Xaa Xaa Ile Xaa Xaa Xaa Xaa Phe Xaa 
705                 710                 715                 720 


Asx Phe Xaa Asx Val Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Asn Xaa Xaa 
                725                 730                 735     


Xaa Xaa Lys Glu Lys Xaa Lys Ala Xaa Ile Gly Leu Tyr Leu Thr Val 
            740                 745                 750         


Xaa Tyr Xaa Xaa Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val 
        755                 760                 765             


Ile Ala Phe His Cys Leu Glu Arg Asp Xaa Xaa Leu Tyr Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Thr Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Leu Lys Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Tyr Arg Asn Xaa Val Xaa His Leu Xaa Ala Xaa Arg 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Tyr Ile Xaa Asp Ile Xaa Xaa Val Xaa Ser Tyr Phe 
865                 870                 875                 880 


Ala Leu Tyr His Tyr Xaa Xaa Gln Arg Xaa Leu Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


His Xaa Thr Tyr Xaa Lys Asp Xaa Val Lys Ala Leu Asn Xaa Pro Phe 
        915                 920                 925             


Gly Tyr Asn Xaa Pro Arg Tyr Lys Asn Leu Ser Ile Xaa Xaa Leu Phe 
    930                 935                 940                 


Asp Arg Asn Glu Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa Lys Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Asp Ser Gln 
                965     


<210>  139
<211>  2718
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Gut metagenome P1E0 nCas1 sequence

<400>  139
atggaacgtg aggtcaaaaa gccccccaaa aaatccttgg caaaggcggc gggactgaag       60

tccaccttcg tcatttcgcc gcaggagaag gagctggcca tgaccgcctt cgggcggggc      120

aacgacgcgc tgctgcaaaa gcgcatcgtg gacggcgtgg tgcgggatgt ggccggagag      180

aagcagcagt ttcaggtgca gcggcaggac gagagccgtt tccgactgca aaacagccgc      240

cttgccgacc gcacggtaac ggcggacgac ccgctgcacc gcgcggagac gccccgccgc      300

cagccgctgg gcgcaggtat ggatcagctg cgccgcaagg caatactgga gcagaaatac      360

ttcggcagga cgtttgacga caacatccac atccaactga tctacaacat attggacatc      420

cacaagatgc tggctgtccc cgccaaccac atcgtccaca cgctgaatct gctgggcgga      480

tacggcgaga cggactttgt ggggatgctg cccgccgggc tgccgtatga caagctgagg      540

gtcgtgaaaa aaaagaacgg cgacaccgtg gacatcaagg cggatatcgc cgcctatgcc      600

aagcggccgc agctggccta tctgggtgcg gcgttctatg acgtgacccc cggcaagagc      660

aaaagggacg cggcgcgggg cagagtcaag cgcgagcagg acgtgtatgc cattctctcg      720

ctgatgagcc ttctgcggca gttctgcgcc cacgacagtg tgcggatatg gggacagaac      780

accaccgccg ccctgtatca tttgcaggcg ctgccgcagg acatgaagga tctgctggat      840

gacggctggc gcagggcgct gggcggcgtc aacgaccatt tcctcgacac caacaaggtg      900

aacctgctga ccctgttcga gtactacggc gccgagacga agcaggcgcg ggtggcgctg      960

acgcaggact tctaccgctt cgtggtgctg aaggagcaga agaacatggg cttctccctg     1020

aggcgtctgc gggaggagct gctgaagctg ccggacgccg cctacctcac cggtcaggag     1080

tacgactcgg tgcggcagaa gctgtatatg ctgctggact tcctgctgtg ccgcctctac     1140

gcgcaggagc gggccgaccg ctgcgaggag ctggtgtccg cgctgcgctg cgccttgtcg     1200

gatgaggaaa aggacaccgt ctatcaggcg gaggccgccg cgctgtggca ggcgctgggc     1260

gacacgctgc gccggaagct gctgccgctg ctgaaaggca aaaagctgca agacaaggac     1320

aagaagaagt cggatgagct ggggctgtcc cgtgacgtgc tggatggtgt gctgttccgc     1380

cccgcacagc agggcagccg cgccaacgcc gactatttct gccggctgat gcacctgtcc     1440

acatggttca tggacggcaa ggagatcaac accctgctga ccaccctcat cagcaagctt     1500

gagaatatcg acagcctgcg gagcgtgctg gagagcatgg gactggcgta cagctttgta     1560

ccggcctacg ccatgtttga ccacagccgc tatatcgccg gtcagctgcg ggtggtcaac     1620

aacatcgcgc ggatgcgtaa gcctgccatc ggcgccaagc gggagatgta ccgcgccgcc     1680

gtggtgctgc tgggcgtgga cagcccggag gcagccgcgg ccatcaccga cgacctgctg     1740

cagatcgacc cggaaacggg gaaggtgcgc ccccgcagcg acagcgcacg ggacacgggt     1800

ctgcggaact tcatcgccaa caacgtggtg gaatcccgcc gcttcaccta cctgctgcgc     1860

tacatgacgc cggagcaggc gcgcgtgctg gcgcagaacg aaaagctcat cgccttcgtg     1920

ctgtccaccg tgcccgacac ccagctggag cgctactgcc gcacctgcgg gcgggaggac     1980

atcaccggcc gtccggcgca gatacgttac ctgacggcgc agatcatggg cgtccggtat     2040

gagagcttca ccgatgtgga gcagcgcggg agaggggata accccaaaaa ggagcggtac     2100

aaggctctca tcggcctgta cctgacggtg ctgtatctgg cggtgaagaa tatggtcaac     2160

tgcaacgccc gctacgtcat cgccttctac tgccgtgacc gtgacacagc gctctatcag     2220

aaggaggtct gctggtacga tctggaggag gacaagaaaa gcggcaagca gcggcaggtg     2280

gaggactaca ccgccctgac ccgctatttt gtgtcgcagg gctatctgaa ccgccatgcc     2340

tgcggctatc tgcgaagcaa tatgaacggc atcagcaaca gcctgctgac cgcctaccgc     2400

aacgcggtgg atcacctgaa cgcgatcccg ccgctgggca gcctgtgccg ggacatcggc     2460

cgggtggaca gctactttgc cctgtaccac tacgccgtgc agcagtatct gaacggcaga     2520

tattacagaa agacgccccg cgagcaggag ctgtttgccg ccatggcgca gcataggaca     2580

tggtgcagcg atctggtgaa ggcactgaac accccctttg gctacaacct cgcccgctac     2640

aagaacctgt ccattgacgg tctgtttgac cgcgagggcg accatgtggt gcgggaggac     2700

ggcgaaaaac cggcggag                                                   2718


<210>  140
<211>  2835
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Anaerobic digester nCas1 sequence

<400>  140
aataacaaaa gaaaaaccaa agctaaggca gctggactca aatccgtttt tttcgaccaa       60

aagcaagctg ttttgacgac ttttgcaaaa ggcaataatt ctcaaatcga aaagaaggtc      120

gtaaatagcg aggttaagga tttgcgacaa ccacctgctt ttgatctcga acttaaagag      180

aagacttttt atatcagcgg taaaaacaac atcaatacct caagagaaaa cccattggct      240

tccgcgtcgc ttcctctaag caagcgacaa cgaattagag cagaaagaat taaacgggcg      300

agagaggaga atcgccccta ccataacgta aagagagtcg gcgaagatga cttacgggcg      360

aaagccgatt tagagaagca ctatttcgga aaagaatact ctgacaattt aaaaattcaa      420

ataatctaca acattctcga tataaataag attatttccc cctatattaa tgatattgtt      480

tattctatga ataatcttgc tcgtaacgac gagtatattg atggcaagat tgatgttatc      540

ggcagtttaa gctcgacgac cgattactct tcatttatga gtccaaataa ggatttagaa      600

aaagaaaaaa aattctcttt tcatcgcgaa aactacaaaa aatttgtcga agcctctaag      660

ccatatatgc gatattatgg aaaagttttt attcgcgatg tcaaaaagag caaactcagc      720

accggcaagg gcgagaaaat cgaagtcatg tatcgctctg acgaggaaat tttcacaatc      780

ttccaaatat taagttatgt tcgtcaaagc atcatgcata atgatatagg caataagtca      840

tcgattttag caatcgaaaa atatcctgcc cgctttgttg ggttcttatc ggacttgctt      900

aaaacaaaaa caaatgatgt caatagaatg ttcatcgata ataatagcca gactaatttc      960

tgggtacttt tttctatctt tggtcttcaa gatcatacga gcggcgcgga caaaatttgt     1020

cgtaattttt atgatttcgt cattaaagcc gatagcaaaa acttaggttt ttcacttaaa     1080

aaaatacggg aattaatgct cgatttgcca aatgccaata tgcttagaga tcatcaattt     1140

gacactgttc gcagcaagtt ttacacactg cttgatttca tcatttacca gcactattta     1200

gaagaaaagt cgcgaataga caatatggtt gagaagttaa gaatgacttt aaaagaggaa     1260

gaaaaggaag tgctttatgc tgccgaggca aaaatagtct ggaacgccat cggggcgaaa     1320

gtcataaaca agcttgttcc gatgatgaat ggcgacgcgc taaaagagat taaaaggaaa     1380

aacagagacc gcaaattgcc tcaaagcgtt atcgcaacgg tccaagttaa ttcagacgct     1440

aacgtattta gtggcctgat atacttcctt accctctttt tagacggcaa agaaattaat     1500

gaaatggtca gcaaccttat taccaaattc gaaaacattg atagtttact ccatgttgat     1560

cgcgaaattt ataaaagcga tgaaaaggat ctcgatttag aaattgaaaa actcgccctt     1620

ttctttaaag gtgtcgtgcg accgaacgct aaaacggata ccggcgccgg agaaatatct     1680

aaatcatttt cgatatttca atccgccgaa agaattatcg aggagctgaa gtttatcaaa     1740

aatgtgacgc ggatggataa tgaaattttc ccatcagaag gagtgttttt agatgcggca     1800

aatgtcttgg gagttagagg cgacgacttc gatttttcaa acgaatttgt cggtgatgat     1860

ttgcattctg acgccaataa aaaaattatc aataagatca acggcaccaa agaagatcgc     1920

aatttgcgca acttcataat aaataatgtt gtcaagtcgc ggcgctttca atatatcgcc     1980

cgccacatga acacacacta tgttaaacaa ctcgccaaca acgaaactct caaccgcttt     2040

gtcttaaata aaatgggtga tgctaaaatc attaaccgct actacgaaag catcagtgga     2100

aacactccaa atatcgaggt tagaagccag atcgattatt tggttaaacg tcttcggagt     2160

ttcagttttg aagatctcaa cgacgtaaaa caaaaagtga ggcccggcac aaatgaaagc     2220

atagaaaagg aaaagaaaaa agcgctagtg ggtctttgct taaccattca atacttggta     2280

tataagaatc tcgtcaatat aaacgctcgt tatacgactg ctttctattg tcttgaacgg     2340

gacagcaaac ttaaaggctt tggagttgat gtttggcgag attttgaaag ctatacagcc     2400

ctgacaaatc actttattaa agagggctat cttcctgtcc gcaaggcaga aattttacga     2460

gcgaatttaa aacatcttga ttgcgaagat ggatttaaat attatcgcaa ccaagtcaca     2520

caccttaacg ccatccgcgt agcatacaaa tatattaacg aaattaaaag tgttcactca     2580

tatttcgcgc tctatcatta tattatgcaa cgccacctat atgattcttt gcaggcaaag     2640

gcaaaagatt ctagtggttt tgttattgac gccttaaaaa agagttttga gcacaagatt     2700

tactcgaagg atcttttgca cgttcttcat tcgcccttcg gttacaatac ggcccgatac     2760

aaaaacttaa gtatcgaggc attatttgac aaaaacgaaa gccggcccga ggtgaatcct     2820

ttatcgacca acgat                                                      2835


<210>  141
<211>  2769
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Ruminococcus sp. CAG:57 nCas1 sequence

<400>  141
atggcaaaaa agaataaaat gaagcctaga gagctgcgtg aggctcagaa aaaagccaga       60

cagctcaaag cggctgagat aaataataac gctgctcctg cgatcgctgc catgcctgct      120

gcagaggtca ttgcacctgt ggcagagaag aaaaaatcct ccgtaaaggc ggcaggaatg      180

aagtctattc ttgtcagcga aaataaaatg tacataacct ctttcggcaa gggcaattct      240

gctgtgcttg aatatgaggt ggacaataat gactacaaca aaactcagct ttcttcaaag      300

gacaacagca atatcgagct tggtgatgta aacgaggtaa acatcacttt ttcaagcaag      360

catggctttg ggagcggagt ggagataaat acttcaaacc ctactcacag aagcggtgaa      420

agctcgcctg taagagggga tatgctgggg cttaaatcgg agcttgaaaa gcgctttttc      480

ggcaaaactt ttgatgataa tatacatatc cagcttattt acaacattct ggatatcgaa      540

aagatacttg cggtgtatgt aacgaatatc gtttatgcgc tgaacaatat gcttggtata      600

aaggattctg aaagttatga tgattttatg gggtatcttt ctgcaagaaa tacttatgaa      660

gtttttactc accctgacaa aagcaatctt tccgataagg taaagggtaa tatcaagaaa      720

agccttagca agtttaatga cttgctgaaa actaagcgcc ttggctattt cggccttgaa      780

gagccaaaga caaaagacac aagagcttcg gaagcataca aaaagcgtgt ttatcatatg      840

cttgcaattg tggggcagat aagacagtgt gtttttcatg ataaatcggg tgcaaaaaga      900

tttgaccttt acagttttat taacaatatt gatcccgaat acagagatac tcttgactat      960

cttgttgagg agcgtttaaa gtccataaac aaggacttta tcgagggtaa caaggtcaat     1020

atcagcctgc ttattgatat gatgaaaggc tatgaggctg atgatatcat acgcctttat     1080

tacgatttca ttgtgcttaa atctcagaaa aatctcggct tttctatcaa aaagcttcgt     1140

gagaaaatgc tggaggaata cggtttcaga tttaaggaca agcaatatga ctctgtgcgc     1200

tcaaagatgt acaagcttat ggatttcctg cttttctgca actactacag aaatgacgtt     1260

gccgcaggcg aagctcttgt gcgtaaactg cgtttttcaa tgaccgatga tgaaaaagag     1320

gggatatatg ctgatgaagc ggcaaagctt tggggcaaat tcaggaatga ttttgaaaat     1380

atcgccgacc acatgaacgg tgacgttatc aaggagcttg gcaaggctga catggatttt     1440

gatgagaaaa ttcttgacag tgaaaagaag aatgcgtctg accttttgta tttctccaaa     1500

atgatatata tgctcacata ttttcttgac ggcaaggaga taaacgatct tcttacaacg     1560

cttatcagca agtttgataa catcaaggag tttttgaaga taatgaaaag ctctgctgtt     1620

gatgttgagt gtgagcttac ggcgggctac aagctgttca atgacagcca gaggataacc     1680

aacgagcttt ttatcgtaaa gaacattgct tccatgagaa agcctgcggc ttcagcgaag     1740

cttacgatgt tccgtgacgc actgactata ctcggtatag acgacaatat cacggacgat     1800

aggataagcg agattctaaa acttaaagaa aaaggcaagg gcatacatgg tctgagaaat     1860

tttataacaa acaatgttat cgagtcctct cggtttgtat accttatcaa gtatgcgaac     1920

gctcagaaga taagagaagt ggctaaggat gagaaagttg tcatgtttgt tcttgggggt     1980

atccctgaca cgcagataga gcgttattac aagagttgtg tggagtttcc tgacatgaat     2040

agttctttgg aagcaaagcg cagtgagctt gcgagaatga taaagaacat cagctttgat     2100

gatttcaaaa atgtgaaaca gcaggcaaag ggcagagaaa acgtggctaa ggagagggca     2160

aaggctgtta tcgggcttta tcttacggtc atgtatctgc tggtgaaaaa tcttgtgaat     2220

gtcaatgcaa ggtatgttat tgcgatacac tgccttgaac gtgattttgg gctgtataag     2280

gagataattc ctgagttggc ttcaaagaac ttgaaaaatg actacaggat actttcacag     2340

acgctttgtg aactttgtga tgatcgtaat gagtcgtcga atttgttctt gaaaaagaac     2400

aagcggctgc gcaagtgcgt tgaagttgat atcaataatg cagacagcag catgacaaga     2460

aaataccgca actgtattgc tcatcttact gtagttcgtg aactgaaaga atacatagga     2520

gatattcgta cagtggattc ttacttctcc atttatcatt atgttatgca gcgttgtatc     2580

acgaaaaggg gagatgacac aaagcaagaa gagaaaataa agtatgagga cgatctttta     2640

aaaaatcacg gctatacgaa agactttgta aaggctctca actcgccgtt tggatacaac     2700

attccgaggt ttaaaaatct ttcaattgag cagttgtttg acagaaatga atatcttact     2760

gaaaagtag                                                             2769


<210>  142
<211>  2715
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized Gut metagenome P1E0 nCas1

<400>  142
gaaagggagg tgaagaagcc tcccaagaaa tccctggcca aagccgccgg actgaagtcc       60

acattcgtca tcagccccca ggaaaaggaa ctcgctatga ccgcctttgg cagaggcaac      120

gatgccctgc tgcaaaagag aatcgtggac ggcgtggtcc gtgatgttgc cggagagaaa      180

cagcagttcc aggtccagag gcaagacgag agcagattca gactccaaaa ctccagactg      240

gccgatagga ccgtcaccgc tgacgacccc ctccacaggg ctgaaacacc caggagacag      300

cctctgggcg ctggcatgga tcagctgagg agaaaagcca ttctggagca aaagtacttt      360

ggcaggacat tcgacgacaa catccacatc cagctgatct acaacatcct ggacatccac      420

aagatgctgg ctgtgcctgc taaccatatc gtgcacaccc tgaacctcct gggaggctac      480

ggcgaaactg attttgtggg aatgctgcct gccggactcc cctacgataa gctcagggtc      540

gtgaagaaaa aaaatggcga taccgtcgac atcaaggccg acattgctgc ctatgccaaa      600

agaccccagc tggcttacct gggagctgcc ttctatgacg tgacccctgg aaaaagcaag      660

cgtgatgctg ccaggggcag ggtgaagagg gaacaggacg tctatgccat tctgtccctc      720

atgtccctgc tgagacaatt ctgcgcccac gatagcgtca ggatctgggg ccagaatacc      780

accgccgccc tgtaccacct ccaggccctg ccccaggata tgaaggacct gctggacgac      840

ggctggagga gagctctggg aggcgtgaat gaccatttcc tcgacaccaa caaggtgaac      900

ctcctcaccc tcttcgagta ctatggcgcc gaaaccaagc aggctagggt ggccctgaca      960

caggactttt acaggttcgt ggtgctgaag gagcagaaga acatgggctt tagcctcagg     1020

aggctgaggg aagagctgct gaagctgccc gacgccgctt acctgaccgg acaggagtac     1080

gactccgtga ggcagaaact gtacatgctc ctggacttcc tgctgtgcag gctgtacgcc     1140

caggagagag ccgatagatg cgaagagctg gtgagcgccc tcagatgtgc tctgagcgac     1200

gaggagaagg atacagtcta ccaagctgaa gccgctgccc tgtggcaagc cctgggcgac     1260

acactcagga ggaaactcct ccccctcctg aagggcaaga aactgcaaga caaggataag     1320

aaaaagtccg acgaactcgg cctgtccagg gatgtgctcg atggcgtgct ctttagacct     1380

gcccagcagg gcagcagagc caacgccgac tacttttgta ggctcatgca cctgagcacc     1440

tggtttatgg acggcaagga gatcaatacc ctgctgacca ccctgatctc caagctggag     1500

aatatcgata gcctgaggtc cgtcctggag tccatgggcc tggcctatag ctttgtccct     1560

gcctacgcca tgtttgacca cagcagatac atcgctggcc agctgagggt ggtgaacaac     1620

atcgccagaa tgaggaaacc cgccattgga gccaaaagag agatgtacag ggccgctgtc     1680

gtgctgctcg gagtggacag ccccgaagct gctgccgcca ttacagacga tctgctgcag     1740

atcgatcccg aaactggaaa ggttcgtcct agatccgact ccgctagaga caccggactg     1800

aggaacttca tcgctaacaa cgtcgtggag agcaggaggt tcacctacct cctgagatac     1860

atgacccctg aacaggccag ggtcctggct caaaacgaga agctgattgc cttcgtgctc     1920

agcacagtgc ccgacaccca gctggagagg tattgtagga cctgtggaag ggaggacatc     1980

acaggcaggc ccgcccagat taggtatctg accgctcaga tcatgggcgt gaggtacgaa     2040

agctttaccg acgtggaaca gaggggaagg ggcgataatc ctaaaaagga gagatacaag     2100

gccctgatcg gcctctacct gacagtgctg tatctggccg tcaaaaatat ggtgaattgt     2160

aacgccaggt acgtgatcgc cttctactgc agggataggg acaccgccct ctaccagaag     2220

gaagtgtgtt ggtatgacct ggaggaggac aagaagtccg gaaagcaaag acaggtcgag     2280

gactatacag ccctgaccag atatttcgtg tcccagggct acctgaacag acacgcctgc     2340

ggctatctca ggtccaacat gaacggcatc agcaacagcc tgctgaccgc ctacagaaat     2400

gccgtggacc acctgaacgc cattcctcct ctgggctccc tgtgtaggga catcggcaga     2460

gtggattcct acttcgctct gtaccactac gccgtgcaac agtacctcaa tggaaggtat     2520

tacagaaaaa cacccagaga acaggaactc ttcgccgcca tggctcagca caggacctgg     2580

tgttccgatc tcgtgaaggc cctgaacacc cctttcggat acaacctggc caggtacaag     2640

aacctctcca tcgacggact gttcgacagg gagggcgatc atgtggtgag agaggatggc     2700

gaaaaacctg ccgaa                                                      2715


<210>  143
<211>  2835
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized Anaerobic Digester  nCas1

<400>  143
aacaacaaga gaaaaacaaa ggctaaagcc gccggcctga agagcgtttt tttcgatcag       60

aagcaggccg tcctgaccac attcgctaaa ggcaacaaca gccagatcga gaagaaggtg      120

gtcaatagcg aagtgaagga cctgagacag ccccctgcct ttgacctcga actgaaagaa      180

aaaacttttt acatcagcgg aaagaataat atcaacacca gcagagagaa ccctctggcc      240

agcgccagcc tgcctctgtc caaaaggcag aggattaggg ctgagaggat caagagggcc      300

agagaggaga acaggcccta ccacaacgtc aaaagggtcg gcgaggatga tctgagggcc      360

aaagccgacc tggagaagca ttattttgga aaggaataca gcgataatct caagatccag      420

atcatttata acattctgga catcaataag atcatcagcc cctacatcaa tgacatcgtg      480

tactccatga acaatctggc caggaatgat gagtatatcg acggcaagat cgatgtgatc      540

ggttctctgt cctccaccac agactatagc agcttcatga gccccaataa ggatctggaa      600

aaggagaaga aattcagctt tcacagagaa aactataaaa aatttgtcga ggcctccaag      660

ccctacatga gatattacgg caaagtcttt atcagggacg tgaaaaaatc caagctgtcc      720

accggcaagg gcgaaaagat cgaggtgatg tacaggagcg atgaagagat tttcaccatc      780

ttccaaatcc tgtcctacgt gaggcagagc atcatgcata atgacattgg caacaagagc      840

agcatcctcg ccatcgaaaa ataccccgcc agattcgtgg gcttcctgtc cgacctctta      900

aaaactaaga ccaacgacgt gaacaggatg ttcatcgata acaatagcca gacaaatttc      960

tgggtcctgt tctccatctt cggcctccag gaccatacaa gcggcgctga taagatctgc     1020

aggaacttct atgatttcgt gatcaaggcc gacagcaaga acctgggatt ctccctgaaa     1080

aagatcaggg agctcatgct ggacctccct aacgctaaca tgctcaggga tcaccagttc     1140

gacacagtga ggagcaagtt ctataccctc ctcgacttta tcatttacca gcattacctg     1200

gaagagaaga gcaggatcga caacatggtc gagaagctca ggatgaccct gaaagaagag     1260

gagaaggagg tgctctacgc tgccgaagcc aagatcgtgt ggaatgccat tggcgccaag     1320

gtcatcaaca agctggtgcc tatgatgaac ggtgatgctc tgaaggagat taaaagaaag     1380

aacagggata ggaagctgcc ccagtccgtg atcgctaccg tccaggtgaa tagcgatgcc     1440

aatgtgtttt ccggcctcat ctacttcctc accctcttcc tggacggcaa agagattaac     1500

gagatggtga gcaatctcat caccaagttc gagaatatcg actccctgct gcatgtggat     1560

agggagatct ataagtccga cgagaaggac ctcgacctcg aaatcgagaa actggctctg     1620

tttttcaaag gcgtggtcag gcccaacgcc aaaacagaca caggagctgg cgaaatcagc     1680

aagagcttca gcattttcca gagcgccgag aggatcatcg aggagctgaa atttatcaag     1740

aatgtgacaa ggatggacaa cgagatcttt cccagcgagg gagtgttcct ggatgctgcc     1800

aatgtgctgg gcgtgagagg agatgacttc gacttttcca acgagttcgt cggcgatgac     1860

ctccactccg atgccaataa aaagatcatc aacaaaatca atggcaccaa ggaggacagg     1920

aacctcagaa acttcattat taataatgtg gtgaagagca ggaggttcca atacatcgcc     1980

aggcacatga atacccacta tgtgaagcag ctggccaaca acgagacact gaacaggttc     2040

gtgctcaaca aaatgggcga cgccaagatt atcaacaggt actatgagtc catcagcggc     2100

aacaccccca atatcgaggt cagatcccag attgactacc tcgtcaaaag actcaggagc     2160

ttctccttcg aggacctcaa tgacgtgaag caaaaagtca gacccggcac caacgaatcc     2220

atcgagaagg aaaagaaaaa ggctctcgtc ggactctgcc tgacaatcca atatctggtg     2280

tacaaaaacc tggtcaacat caacgctagg tacaccacag ccttctactg cctggaaagg     2340

gattccaagc tgaagggctt tggcgtggat gtgtggaggg atttcgagag ctacaccgct     2400

ctgaccaacc acttcatcaa ggaaggctat ctccccgtca ggaaggccga gattctgaga     2460

gccaatctga agcatctgga ctgcgaggac ggcttcaagt attacagaaa ccaggtcacc     2520

catctgaacg ccatcagagt ggcttataag tatattaacg aaattaagtc cgtgcacagc     2580

tactttgccc tgtaccacta catcatgcag aggcacctct atgactccct ccaagccaaa     2640

gccaaggata gctccggctt cgtcattgac gccctgaaga agtccttcga acataaaatc     2700

tacagcaaag acctcctgca cgtgctccat tcccctttcg gctacaacac cgccaggtac     2760

aagaacctga gcatcgaggc tctgttcgac aagaatgaga gcaggcctga agtcaacccc     2820

ctctccacca acgac                                                      2835


<210>  144
<211>  2898
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized Ruminococcus flavefaciens XPD nCas1

<400>  144
atcgaaaaaa aaaagtcctt cgccaagggc atgggcgtga agtccacact cgtgtccggc       60

tccaaagtgt acatgacaac cttcgccgaa ggcagcgacg ccaggctgga aaagatcgtg      120

gagggcgaca gcatcaggag cgtgaatgag ggcgaggcct tcagcgctga aatggccgat      180

aaaaacgccg gctataagat cggcaacgcc aaattcagcc atcctaaggg ctacgccgtg      240

gtggctaaca accctctgta tacaggaccc gtccagcagg atatgctcgg cctgaaggaa      300

actctggaaa agaggtactt cggcgagagc gctgatggca atgacaatat ttgtatccag      360

gtgatccata acatcctgga cattgaaaaa atcctcgccg aatacattac caacgccgcc      420

tacgccgtca acaatatctc cggcctggat aaggacatta ttggattcgg caagttctcc      480

acagtgtata cctacgacga attcaaagac cccgagcacc atagggccgc tttcaacaat      540

aacgataagc tcatcaacgc catcaaggcc cagtatgacg agttcgacaa cttcctcgat      600

aaccccagac tcggctattt cggccaggcc tttttcagca aggagggcag aaattacatc      660

atcaattacg gcaacgaatg ctatgacatt ctggccctcc tgagcggact gaggcactgg      720

gtggtccata acaacgaaga agagtccagg atctccagga cctggctcta caacctcgat      780

aagaacctcg acaacgaata catctccacc ctcaactacc tctacgacag gatcaccaat      840

gagctgacca actccttctc caagaactcc gccgccaacg tgaactatat tgccgaaact      900

ctgggaatca accctgccga attcgccgaa caatatttca gattcagcat tatgaaagag      960

cagaaaaacc tcggattcaa tatcaccaag ctcagggaag tgatgctgga caggaaggat     1020

atgtccgaga tcaggaaaaa tcataaggtg ttcgactcca tcaggaccaa ggtctacacc     1080

atgatggact ttgtgattta taggtattac atcgaagagg atgccaaggt ggctgccgcc     1140

aataagtccc tccccgataa tgagaagtcc ctgagcgaga aggatatctt tgtgattaac     1200

ctgaggggct ccttcaacga cgaccagaag gatgccctct actacgatga agctaataga     1260

atttggagaa agctcgaaaa tatcatgcac aacatcaagg aatttagggg aaacaagaca     1320

agagagtata agaagaagga cgcccctaga ctgcccagaa tcctgcccgc tggccgtgat     1380

gtttccgcct tcagcaaact catgtatgcc ctgaccatgt tcctggatgg caaggagatc     1440

aacgacctcc tgaccaccct gattaataaa ttcgataaca tccagagctt cctgaaggtg     1500

atgcctctca tcggagtcaa cgctaagttc gtggaggaat acgccttttt caaagactcc     1560

gccaagatcg ccgatgagct gaggctgatc aagtccttcg ctagaatggg agaacctatt     1620

gccgatgcca ggagggccat gtatatcgac gccatccgta ttttaggaac caacctgtcc     1680

tatgatgagc tcaaggccct cgccgacacc ttttccctgg acgagaacgg aaacaagctc     1740

aagaaaggca agcacggcat gagaaatttc attattaata acgtgatcag caataaaagg     1800

ttccactacc tgatcagata cggtgatcct gcccacctcc atgagatcgc caaaaacgag     1860

gccgtggtga agttcgtgct cggcaggatc gctgacatcc agaaaaaaca gggccagaac     1920

ggcaagaacc agatcgacag gtactacgaa acttgtatcg gaaaggataa gggcaagagc     1980

gtgagcgaaa aggtggacgc tctcacaaag atcatcaccg gaatgaacta cgaccaattc     2040

gacaagaaaa ggagcgtcat tgaggacacc ggcagggaaa acgccgagag ggagaagttt     2100

aaaaagatca tcagcctgta cctcaccgtg atctaccaca tcctcaagaa tattgtcaat     2160

atcaacgcca ggtacgtcat cggattccat tgcgtcgagc gtgatgctca actgtacaag     2220

gagaaaggct acgacatcaa tctcaagaaa ctggaagaga agggattcag ctccgtcacc     2280

aagctctgcg ctggcattga tgaaactgcc cccgataaga gaaaggacgt ggaaaaggag     2340

atggctgaaa gagccaagga gagcattgac agcctcgaga gcgccaaccc caagctgtat     2400

gccaattaca tcaaatacag cgacgagaag aaagccgagg agttcaccag gcagattaac     2460

agggagaagg ccaaaaccgc cctgaacgcc tacctgagga acaccaagtg gaatgtgatc     2520

atcagggagg acctcctgag aattgacaac aagacatgta ccctgttcag aaacaaggcc     2580

gtccacctgg aagtggccag gtatgtccac gcctatatca acgacattgc cgaggtcaat     2640

tcctacttcc aactgtacca ttacatcatg cagagaatta tcatgaatga gaggtacgag     2700

aaaagcagcg gaaaggtgtc cgagtacttc gacgctgtga atgacgagaa gaagtacaac     2760

gataggctcc tgaaactgct gtgtgtgcct ttcggctact gtatccccag gtttaagaac     2820

ctgagcatcg aggccctgtt cgataggaac gaggccgcca agttcgacaa ggagaaaaag     2880

aaggtgtccg gcaattcc                                                   2898


<210>  145
<211>  2829
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human codon-optimized Ruminococcus albus nCas1

<400>  145
gccaagaagt ccaagggaat gtccctcagg gagaagaggg agctggagaa gcaaaagagg       60

attcagaagg ccgccgtgaa tagcgtgaac gatacccctg aaaaaactga ggaggctaat      120

gtggtcagcg tgaacgtgag aaccagcgcc gagaacaagc actccaaaaa gagcgctgcc      180

aaagccctgg gcctgaaaag cggcctcgtg attggagatg agctctacct gaccagcttc      240

ggaaggggca acgaagccaa gctggagaag aagattagcg gcgacaccgt ggagaaactg      300

ggaattggcg cctttgaggt cgccgaacgt gatgaaagca cactcacact cgagagcggc      360

aggatcaaag acaaaaccgc caggcctaag gaccccagac atattaccgt ggacacccag      420

ggaaagttta aggaggacat gctgggcatc aggtccgtgc tcgaaaagaa gatctttgga      480

aaaaccttcg acgataacat ccacgtccag ctggcctaca acatcctgga cgtcgagaag      540

atcatggctc agtatgtgag cgacatcgtc tacatgctgc acaacaccga caagaccgag      600

aggaacgata acctgatggg atacatgtcc attagaaata cctacaaaac cttctgcgac      660

acatccaatc tgcccgacga cacaaagcag aaggtggaga atcagaaaag ggaattcgac      720

aagatcatta agagcggcag actgggctac ttcggcgaag ctttcatggt caacagcggc      780

aactccacca agctgaggcc cgagaaagag atttatcata tcttcgccct catggccagc      840

ctgaggcaga gctacttcca cggatacgtc aaggataccg actatcaggg cacaacatgg      900

gcctacacac tggaggataa gctgaagggc cccagccatg aatttaggga gacaatcgac      960

aagatctttg acgagggatt cagcaagatc tccaaggact tcggaaaaat gaacaaagtg     1020

aatctccaaa tcctggagca gatgatcggc gagctgtacg gaagcatcga aaggcagaac     1080

ctgacctgcg attactacga ttttattcaa ctcaagaagc acaagtatct cggctttagc     1140

atcaagaggc tgagagagac aatgctcgag acaacccctg ccgagtgtta taaggctgag     1200

tgctacaata gcgagaggca aaagctctac aagctgatcg acttcctcat ctacgacctc     1260

tactataaca ggaagcccgc cagaatcgaa gagatcgtcg acaagctgag agagagcgtc     1320

aacgacgagg agaaggagag catctatagc gtggaggcca agtacgtgta tgagtccctg     1380

agcaaggtgc tggataagag cctgaagaat tccgtgtccg gcgaaactat caaggatctg     1440

cagaagaggt acgacgacga aactgccaac agaatttggg acatctccca gcactccatt     1500

tccggcaatg tcaactgctt ctgcaagctg atctacatta tgaccctcat gctggatgga     1560

aaggagatca acgacctcct caccaccctg gtgaacaagt ttgacaatat tgcttccttt     1620

attgacgtga tggacgaact cggcctggaa cacagcttta cagacaacta caagatgttt     1680

gccgacagca aggccatctg cctggacctg caattcatca atagctttgc tagaatgagc     1740

aagatcgacg acgagaaaag caagagacag ctgttcaggg atgctctggt gatcctcgat     1800

atcggaaaca aggacgaaac ttggattaac aactacctcg actccgacat cttcaagctg     1860

gacaaggaag gcaacaagct gaagggagcc aggcatgact ttaggaattt tatcgccaat     1920

aatgtcatta agtcctccag attcaagtac ctcgtcaaat acagctccgc cgacggcatg     1980

attaagttaa aaactaacga aaagctgatt ggcttcgtgc tcgacaagct ccccgaaact     2040

caaatcgata ggtactacga atcctgcggc ctcgacaatg ccgtcgtgga caagaaggtg     2100

aggatcgaga aactgtccgg actcatcagg gacatgaagt tcgacgattt ttccggcgtc     2160

aagacctcca ataaggccgg cgacaacgat aagcaggaca aggccaagta ccaggccatt     2220

atctccctgt acctgatggt gctctaccag attgtgaaga atatgatcta cgtcaacagc     2280

aggtatgtga ttgccttcca ctgcctggag agggacttcg gaatgtacgg caaggatttc     2340

ggcaagtact accagggctg taggaagctc accgatcatt tcatcgagga gaaatacatg     2400

aaggagggca agctgggctg taacaagaaa gtcggcaggt acctgaagaa taacatcagc     2460

tgttgcaccg acggcctgat taacacctac aggaaccagg tcgatcattt cgccgtcgtc     2520

agaaaaatcg gaaattacgc cgcctacatc aaatccattg gcagctggtt cgagctctat     2580

cattacgtga ttcagaggat cgtttttgac gaatatagat tcgccctcaa caacaccgag     2640

tccaactata agaacagcat cattaagcac catacatact gcaaggacat ggtgaaggcc     2700

ctgaataccc ctttcggcta cgacctgccc agatataaaa acctgagcat tggtgattta     2760

ttcgacagga acaactatct gaacaaaaca aaggagtcca tcgatgccaa ctccagcatt     2820

gatagccag                                                             2829


<210>  146
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  exemplary processed Ruminococcus sp. CAG:57 CRISPR array

<400>  146
ctactacact ggtgcgaatt tgcactagtc taaaacaagc tttttcttca ttgtctacaa       60

atgcaactac tacactagtg cgaatttgca ctagtctaaa actctatgta gcttttcttg      120

taaaacatat ttctactaca ctggtgcgat tttgcactag tctaaaactc atctgccttc      180

tgcatatcgg acacttgact actacaccgg tgcgaatttg cactagtcta aaacttacac      240

ctccttatgc gattttatcg tgcgctacta cactggtgcg aatttgcact agtctaaaac      300

ttcatcttca agaccgagca gggacatcat                                       330


<210>  147
<211>  939
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession):  contig emb|OBVH01003037.1, human gut metagenome sequence (also found in WGS contigs emb|OBXZ01000094.1| and emb|OBJF01000033.1|)

<400>  147

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Leu Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Gly Leu Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Gln Ser Lys Trp Glu Lys 
225                 230                 235                 240 


Arg Asp Asn Phe Ile Lys Phe Tyr Asn Glu Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asp Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Phe Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Thr Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Arg Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Val Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


Asn Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Ala Pro Gln Glu Pro Leu 
            580                 585                 590         


Leu Lys Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Asn Lys Tyr Phe Asp Ser Lys Glu Lys Thr Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Gly Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Lys Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Asp Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Lys Tyr Asn Lys Phe Phe Thr Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Lys Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asn Tyr Cys Lys Glu Lys Asn 
865                 870                 875                 880 


Asp Val Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asn Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  148
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR sequence

<400>  148
gattgaaagg attgtaaatt tgcaaggtct taaaac                                 36


<210>  149
<211>  958
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession):  contig tpg|DBYI01000091.1| (Uncultivated Ruminococcus flavefaciens UBA1190 assembled from bovine gut metagenome)

<400>  149

Met Lys Lys Lys Ile Lys Ala Arg Asp Leu Arg Glu Ala Lys Lys Gln 
1               5                   10                  15      


Glu Lys Leu Ala Ala Phe Ser Ala Lys Ala Asn Thr Val Tyr Glu Asn 
            20                  25                  30          


Glu Asp Lys Asn Val Glu Ala Phe Pro Glu Ala Leu Asn Leu Arg Ser 
        35                  40                  45              


Ile Lys Lys Ser Met Asn Lys Ala Ala Gly Leu Lys Ser Thr Leu Ile 
    50                  55                  60                  


Asp Gly Lys Ser Leu Tyr Leu Thr Ala Phe Gly Lys Gly Asn Asn Ala 
65                  70                  75                  80  


Val Val Glu His Met Ile Ala Thr Asp Asp Ser Tyr Ser Leu Lys Thr 
                85                  90                  95      


Leu Glu Asn Glu Pro Ser Leu Lys Val Lys Ala Ala Asp Glu Leu Lys 
            100                 105                 110         


Val Thr Phe Met Ser Arg Arg Pro Phe Val Gln Glu Ser Glu Leu Ser 
        115                 120                 125             


Ala Val Asn Pro Leu His Ser Gly Lys Asp Lys Pro Asn Lys Ser Ala 
    130                 135                 140                 


Gly Gln Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Tyr Phe 
145                 150                 155                 160 


Gly Lys Ile Phe Asp Asp Asn Leu His Ile Gln Ile Ile His Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Ile Ala Val Tyr Ala Thr Asn Ile Thr Ala 
            180                 185                 190         


Ala Ile Asp His Met Val Asp Asp Asp Asn Glu Gln Tyr Leu Gln Gly 
        195                 200                 205             


Asp Phe Ile Gly Tyr Met Asn Thr Leu Asn Thr Tyr Glu Val Phe Met 
    210                 215                 220                 


Glu Pro Ser Lys Asn Pro Arg Leu Asp Ser Asn Ala Arg Lys Asn Ile 
225                 230                 235                 240 


Glu Asn Ser Arg Glu Lys Phe Glu Tyr Leu Leu Asp Thr Gln Arg Leu 
                245                 250                 255     


Gly Tyr Leu Ser Leu Glu Tyr Asp Lys Arg Ser Lys Asp Lys Arg Lys 
            260                 265                 270         


Ser Glu Glu Ile Lys Lys Arg Leu Tyr His Leu Val Ala Phe Ala Gly 
        275                 280                 285             


Gln Leu Arg Gln Trp Ser Phe His Ser Val Glu Gly Leu Pro Arg Thr 
    290                 295                 300                 


Trp Ile Tyr Gln Leu Asp Asn Pro Lys Leu Ala Gln Glu Tyr Arg Asp 
305                 310                 315                 320 


Thr Leu Asp Tyr Phe Phe Asn Glu Arg Phe Asp Ala Ile Asn Lys Asp 
                325                 330                 335     


Phe Ile Glu Thr Asn Asn Ile Asn Leu His Ile Leu Lys Glu Val Phe 
            340                 345                 350         


Pro Ala Glu Asp Phe Gln Lys Leu Ala Ala Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Lys Lys Thr Phe Lys Asn Ile Gly Phe Ser Ile Lys Asn Leu Arg 
    370                 375                 380                 


Glu Gln Met Leu Glu Cys Asp Glu Ala Glu Lys Ile Arg Ser Lys Asp 
385                 390                 395                 400 


Met Asn Ser Val Arg Ser Lys Leu Tyr Lys Leu Phe Asp Phe Cys Ile 
                405                 410                 415     


Phe Tyr Gln Tyr Phe Ile Asp Glu Glu Arg Ser Arg Glu Asn Val Asn 
            420                 425                 430         


Tyr Leu Arg Ser Thr Leu Asn Asp Glu Gln Lys Asp Ala Phe Tyr Glu 
        435                 440                 445             


Glu Glu Gly Lys Arg Leu Trp Ser Glu Asn Arg Lys Lys Phe Ile Tyr 
    450                 455                 460                 


Phe Cys Asp Asn Ile Asn Lys Trp Val Lys Asn Asp Tyr Ser Asp Glu 
465                 470                 475                 480 


Val Ala Lys Cys Ile Asp Leu Asn Glu Phe Arg Val Asn Ser Asn Val 
                485                 490                 495     


Ser Tyr Phe Ser Lys Leu Leu Tyr Ala Met Ser Phe Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn 
        515                 520                 525             


Ile Arg Ser Phe Ile Asp Thr Ala Asn Phe Leu Asn Ile Asp Val Lys 
    530                 535                 540                 


Phe Thr Lys Asp Tyr Asp Phe Phe Asn Ile Ile Cys Asp Tyr Ala Gly 
545                 550                 555                 560 


Glu Leu Asn Ile Ile Lys Asn Ile Ala Arg Met Lys Lys Pro Ser Pro 
                565                 570                 575     


Ser Ala Lys Lys Asn Met Tyr Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Pro Thr Glu Met Ser Asp Glu Gln Leu Asp Ala Glu Ile Asp Lys Ile 
        595                 600                 605             


Leu Glu Lys Lys Ile Asn Pro Val Thr Gly Lys Thr Glu Lys Gly Lys 
    610                 615                 620                 


Asn Pro Phe Arg Asn Phe Ile Ala Asn Asn Val Ile Glu Asn Lys Arg 
625                 630                 635                 640 


Phe Ile Tyr Val Ile Lys Phe Cys Asn Pro Lys Asn Val Arg Lys Leu 
                645                 650                 655     


Val Asn Asn Thr Lys Val Thr Glu Phe Val Leu Lys Arg Met Pro Glu 
            660                 665                 670         


Thr Gln Ile Asp Arg Tyr Phe Glu Ser Cys Ile Glu Gly Asn Leu Asn 
        675                 680                 685             


Pro Thr Thr Glu Lys Lys Ile Glu Lys Leu Ala Glu Met Ile Lys Asn 
    690                 695                 700                 


Ile Lys Phe Glu Glu Phe Arg Asn Val Lys Gln Lys Val Arg Asp Asn 
705                 710                 715                 720 


Ser Gln Glu Ala Val Glu Lys Glu Arg Phe Lys Ala Ile Ile Gly Leu 
                725                 730                 735     


Tyr Leu Thr Val Ile Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn 
            740                 745                 750         


Ser Arg Tyr Val Met Ala Phe His Cys Leu Glu Arg Asp Ala Lys Leu 
        755                 760                 765             


Tyr Gly Val Gln Asn Ile Gly Gly Asp Tyr Leu Ala Leu Thr Ala Lys 
    770                 775                 780                 


Leu Cys Ala Glu Gly Asp Asp Tyr Gly Lys Lys Leu Ser Glu Ala Lys 
785                 790                 795                 800 


Gln Asn Ile Asn Gln Asp Lys Val Gln Met Pro Lys Asn Tyr Phe Leu 
                805                 810                 815     


Ala Arg Asn Lys Arg Trp Arg Glu Ala Ile Glu Gln Asp Ile Asp Asn 
            820                 825                 830         


Ala Lys Lys Trp Phe Ile Gly Glu Lys Phe Asn Asn Val Lys Asn Tyr 
        835                 840                 845             


Arg Asn Asn Val Ala His Leu Thr Ala Ile Arg Asn Cys Ala Glu Phe 
    850                 855                 860                 


Ile Gly Glu Ile Thr Lys Ile Asp Ser Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Arg Gln Leu Ala Gly Arg Leu Asp Pro Asn His Pro Gly 
                885                 890                 895     


Phe Glu Lys Asn Tyr Pro Gln Tyr Ala Pro Leu Phe Lys Trp Asn Thr 
            900                 905                 910         


Tyr Val Lys Asp Met Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
        915                 920                 925             


Ile Pro Arg Phe Lys Asp Leu Ser Ile Asp Ala Leu Phe Asp Arg Asn 
    930                 935                 940                 


Glu Met Lys Glu Glu Thr Asp Asp Glu Lys Lys Ile Gln Thr 
945                 950                 955             


<210>  150
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR 1

<400>  150
gaactatacc cctaccaaat ggtcggggtc tgaaac                                 36


<210>  151
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR 2

<400>  151
tgaactacac ccctgccaag tggttggggt ctgaaac                                37


<210>  152
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR 3

<400>  152
gaactacacc cctaccaagt ggttggggtc tgaaac                                 36


<210>  153
<211>  877
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession):  contig tpg|DJXD01000002.1| (uncultivated Ruminococcus assembly, UBA7013, from sheep gut metagenome)

<400>  153

Met Lys Lys Gln Lys Ser Lys Lys Thr Val Ser Lys Thr Ser Gly Leu 
1               5                   10                  15      


Lys Glu Ala Leu Ser Val Gln Gly Thr Val Ile Met Thr Ser Phe Gly 
            20                  25                  30          


Lys Gly Asn Met Ala Asn Leu Ser Tyr Lys Ile Pro Ser Ser Gln Lys 
        35                  40                  45              


Pro Gln Asn Leu Asn Ser Ser Ala Gly Leu Lys Asn Val Glu Val Ser 
    50                  55                  60                  


Gly Lys Lys Ile Lys Phe Gln Gly Arg His Pro Lys Ile Ala Thr Thr 
65                  70                  75                  80  


Asp Asn Pro Leu Phe Lys Pro Gln Pro Gly Met Asp Leu Leu Cys Leu 
                85                  90                  95      


Lys Asp Lys Leu Glu Met His Tyr Phe Gly Lys Thr Phe Asp Asp Asn 
            100                 105                 110         


Ile His Ile Gln Leu Ile Tyr Gln Ile Leu Asp Ile Glu Lys Ile Leu 
        115                 120                 125             


Ala Val His Val Asn Asn Ile Val Phe Thr Leu Asp Asn Val Leu His 
    130                 135                 140                 


Pro Gln Lys Glu Glu Leu Thr Glu Asp Phe Ile Gly Ala Gly Gly Trp 
145                 150                 155                 160 


Arg Ile Asn Leu Asp Tyr Gln Thr Leu Arg Gly Gln Thr Asn Lys Tyr 
                165                 170                 175     


Asp Arg Phe Lys Asn Tyr Ile Lys Arg Lys Glu Leu Leu Tyr Phe Gly 
            180                 185                 190         


Glu Ala Phe Tyr His Glu Asn Glu Arg Arg Tyr Glu Glu Asp Ile Phe 
        195                 200                 205             


Ala Ile Leu Thr Leu Leu Ser Ala Leu Arg Gln Phe Cys Phe His Ser 
    210                 215                 220                 


Asp Leu Ser Ser Asp Glu Ser Asp His Val Asn Ser Phe Trp Leu Tyr 
225                 230                 235                 240 


Gln Leu Glu Asp Gln Leu Ser Asp Glu Phe Lys Glu Thr Leu Ser Ile 
                245                 250                 255     


Leu Trp Glu Glu Val Thr Glu Arg Ile Asp Ser Glu Phe Leu Lys Thr 
            260                 265                 270         


Asn Thr Val Asn Leu His Ile Leu Cys His Val Phe Pro Lys Glu Ser 
        275                 280                 285             


Lys Glu Thr Ile Val Arg Ala Tyr Tyr Glu Phe Leu Ile Lys Lys Ser 
    290                 295                 300                 


Phe Lys Asn Met Gly Phe Ser Ile Lys Lys Leu Arg Glu Ile Met Leu 
305                 310                 315                 320 


Glu Gln Ser Asp Leu Lys Ser Phe Lys Glu Asp Lys Tyr Asn Ser Val 
                325                 330                 335     


Arg Ala Lys Leu Tyr Lys Leu Phe Asp Phe Ile Ile Thr Tyr Tyr Tyr 
            340                 345                 350         


Asp His His Ala Phe Glu Lys Glu Ala Leu Val Ser Ser Leu Arg Ser 
        355                 360                 365             


Ser Leu Thr Glu Glu Asn Lys Glu Glu Ile Tyr Ile Lys Thr Ala Arg 
    370                 375                 380                 


Thr Leu Ala Ser Ala Leu Gly Ala Asp Phe Lys Lys Ala Ala Ala Asp 
385                 390                 395                 400 


Val Asn Ala Lys Asn Ile Arg Asp Tyr Gln Lys Lys Ala Asn Asp Tyr 
                405                 410                 415     


Arg Ile Ser Phe Glu Asp Ile Lys Ile Gly Asn Thr Gly Ile Gly Tyr 
            420                 425                 430         


Phe Ser Glu Leu Ile Tyr Met Leu Thr Leu Leu Leu Asp Gly Lys Glu 
        435                 440                 445             


Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Ile 
    450                 455                 460                 


Ser Phe Ile Asp Ile Leu Lys Lys Leu Asn Leu Glu Phe Lys Phe Lys 
465                 470                 475                 480 


Pro Glu Tyr Ala Asp Phe Phe Asn Met Thr Asn Cys Arg Tyr Thr Leu 
                485                 490                 495     


Glu Glu Leu Arg Val Ile Asn Ser Ile Ala Arg Met Gln Lys Pro Ser 
            500                 505                 510         


Ala Asp Ala Arg Lys Ile Met Tyr Arg Asp Ala Leu Arg Ile Leu Gly 
        515                 520                 525             


Met Asp Asn Arg Pro Asp Glu Glu Ile Asp Arg Glu Leu Glu Arg Thr 
    530                 535                 540                 


Met Pro Val Gly Ala Asp Gly Lys Phe Ile Lys Gly Lys Gln Gly Phe 
545                 550                 555                 560 


Arg Asn Phe Ile Ala Ser Asn Val Ile Glu Ser Ser Arg Phe His Tyr 
                565                 570                 575     


Leu Val Arg Tyr Asn Asn Pro His Lys Thr Arg Thr Leu Val Lys Asn 
            580                 585                 590         


Pro Asn Val Val Lys Phe Val Leu Glu Gly Ile Pro Glu Thr Gln Ile 
        595                 600                 605             


Lys Arg Tyr Phe Asp Val Cys Lys Gly Gln Glu Ile Pro Pro Thr Ser 
    610                 615                 620                 


Asp Lys Ser Ala Gln Ile Asp Val Leu Ala Arg Ile Ile Ser Ser Val 
625                 630                 635                 640 


Asp Tyr Lys Ile Phe Glu Asp Val Pro Gln Ser Ala Lys Ile Asn Lys 
                645                 650                 655     


Asp Asp Pro Ser Arg Asn Phe Ser Asp Ala Leu Lys Lys Gln Arg Tyr 
            660                 665                 670         


Gln Ala Ile Val Ser Leu Tyr Leu Thr Val Met Tyr Leu Ile Thr Lys 
        675                 680                 685             


Asn Leu Val Tyr Val Asn Ser Arg Tyr Val Ile Ala Phe His Cys Leu 
    690                 695                 700                 


Glu Arg Asp Ala Phe Leu His Gly Val Thr Leu Pro Lys Met Asn Lys 
705                 710                 715                 720 


Lys Ile Val Tyr Ser Gln Leu Thr Thr His Leu Leu Thr Asp Lys Asn 
                725                 730                 735     


Tyr Thr Thr Tyr Gly His Leu Lys Asn Gln Lys Gly His Arg Lys Trp 
            740                 745                 750         


Tyr Val Leu Val Lys Asn Asn Leu Gln Asn Ser Asp Ile Thr Ala Val 
        755                 760                 765             


Ser Ser Phe Arg Asn Ile Val Ala His Ile Ser Val Val Arg Asn Ser 
    770                 775                 780                 


Asn Glu Tyr Ile Ser Gly Ile Gly Glu Leu His Ser Tyr Phe Glu Leu 
785                 790                 795                 800 


Tyr His Tyr Leu Val Gln Ser Met Ile Ala Lys Asn Asn Trp Tyr Asp 
                805                 810                 815     


Thr Ser His Gln Pro Lys Thr Ala Glu Tyr Leu Asn Asn Leu Lys Lys 
            820                 825                 830         


His His Thr Tyr Cys Lys Asp Phe Val Lys Ala Tyr Cys Ile Pro Phe 
        835                 840                 845             


Gly Tyr Val Val Pro Arg Tyr Lys Asn Leu Thr Ile Asn Glu Leu Phe 
    850                 855                 860                 


Asp Arg Asn Asn Pro Asn Pro Glu Pro Lys Glu Glu Val 
865                 870                 875         


<210>  154
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  154
caactacaac cccgtaaaaa tacggggttc tgaaac                                 36


<210>  155
<211>  984
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession): contig OGZC01000639.1  (human gut metagenome assembly)

<400>  155

Met Lys Lys Lys Asn Ile Arg Ala Thr Arg Glu Ala Leu Lys Ala Gln 
1               5                   10                  15      


Lys Ile Lys Lys Ser Gln Glu Asn Glu Ala Leu Lys Lys Gln Lys Leu 
            20                  25                  30          


Ala Glu Glu Ala Ala Gln Lys Arg Arg Glu Glu Leu Glu Lys Lys Asn 
        35                  40                  45              


Leu Ala Gln Trp Glu Glu Thr Ser Ala Glu Gly Arg Arg Ser Arg Val 
    50                  55                  60                  


Lys Ala Val Gly Val Lys Ser Val Phe Val Val Gly Asp Asp Leu Tyr 
65                  70                  75                  80  


Leu Ala Thr Phe Gly Asn Gly Asn Glu Thr Val Leu Glu Lys Lys Ile 
                85                  90                  95      


Thr Pro Asp Gly Lys Ile Thr Thr Phe Pro Glu Glu Glu Thr Phe Thr 
            100                 105                 110         


Ala Lys Leu Lys Phe Ala Gln Thr Glu Pro Thr Val Ala Thr Ser Ile 
        115                 120                 125             


Gly Ile Ser Asn Gly Arg Ile Val Leu Pro Glu Ile Ser Val Asp Asn 
    130                 135                 140                 


Pro Leu His Thr Thr Met Gln Lys Asn Thr Ile Lys Arg Ser Ala Gly 
145                 150                 155                 160 


Glu Asp Ile Leu Gln Leu Lys Asp Val Leu Glu Asn Arg Tyr Phe Asp 
                165                 170                 175     


Arg Ser Phe Asn Asp Asp Leu His Ile Arg Leu Ile Tyr Asn Ile Leu 
            180                 185                 190         


Asp Ile Glu Lys Ile Leu Ala Glu Tyr Thr Thr Asn Ala Val Phe Ala 
        195                 200                 205             


Ile Asp Asn Val Ser Gly Cys Ser Asp Asp Phe Leu Ser Asn Phe Ser 
    210                 215                 220                 


Thr Arg Asn Gln Trp Asp Glu Phe Gln Asn Pro Glu Gln His Arg Glu 
225                 230                 235                 240 


His Phe Gly Asn Lys Asp Asn Val Ile Cys Ser Val Lys Lys Gln Gln 
                245                 250                 255     


Asp Leu Phe Phe Asn Phe Phe Lys Asn Asn Arg Ile Gly Tyr Phe Gly 
            260                 265                 270         


Lys Ala Phe Phe His Ala Glu Ser Glu Arg Lys Ile Val Lys Lys Thr 
        275                 280                 285             


Glu Lys Glu Val Tyr His Ile Leu Thr Leu Ile Gly Ser Leu Arg Gln 
    290                 295                 300                 


Trp Ile Thr His Ser Thr Glu Gly Gly Ile Ser Arg Leu Trp Leu Tyr 
305                 310                 315                 320 


Gln Leu Glu Asp Ala Leu Ser Arg Glu Tyr Gln Glu Thr Met Asn Asn 
                325                 330                 335     


Cys Tyr Asn Ser Thr Ile Tyr Gly Leu Gln Lys Asp Phe Glu Lys Thr 
            340                 345                 350         


Asn Ala Pro Asn Leu Asn Phe Leu Ala Glu Ile Leu Gly Lys Asn Ala 
        355                 360                 365             


Ser Glu Leu Ala Glu Pro Tyr Phe Arg Phe Ile Ile Thr Lys Glu Tyr 
    370                 375                 380                 


Lys Asn Leu Gly Phe Ser Ile Lys Thr Leu Arg Glu Met Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Asp Leu Gln Glu Ile Arg Glu Asn His Asn Val Tyr Asp Ser 
                405                 410                 415     


Ile Arg Ser Lys Leu Tyr Lys Met Ile Asp Phe Val Leu Val Tyr Ala 
            420                 425                 430         


Tyr Ser Asn Glu Arg Lys Ser Lys Ala Asp Ala Leu Ala Ser Asn Leu 
        435                 440                 445             


Arg Ser Ala Ile Thr Glu Asp Ala Lys Lys Arg Ile Tyr Gln Asn Glu 
    450                 455                 460                 


Ala Asp Gln Leu Trp Thr Ser Tyr Gln Glu Leu Phe Lys Arg Ile Arg 
465                 470                 475                 480 


Gly Phe Lys Gly Ala Gln Val Lys Glu Tyr Ser Ser Lys Asn Met Pro 
                485                 490                 495     


Ile Pro Ile Gln Lys Gln Ile Gln Asn Ile Leu Lys Pro Ala Glu Gln 
            500                 505                 510         


Val Thr Tyr Phe Thr Lys Leu Met Tyr Leu Leu Thr Met Phe Leu Asp 
        515                 520                 525             


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp 
    530                 535                 540                 


Asn Ile Ser Ser Leu Leu Lys Thr Met Glu Gln Leu Glu Leu Gln Thr 
545                 550                 555                 560 


Thr Phe Lys Glu Asp Tyr Thr Phe Phe Gln Gln Ser Ser Arg Leu Cys 
                565                 570                 575     


Lys Glu Ile Thr Gln Leu Lys Ser Phe Ala Arg Met Gly Asn Pro Ile 
            580                 585                 590         


Ser Asn Leu Lys Glu Val Met Met Val Asp Ala Ile Gln Ile Leu Gly 
        595                 600                 605             


Thr Glu Lys Ser Glu Gln Glu Leu Gln Ser Met Ala Cys Phe Phe Phe 
    610                 615                 620                 


Arg Asp Lys Asn Gly Lys Lys Leu Asn Thr Gly Glu His Gly Met Arg 
625                 630                 635                 640 


Asn Phe Ile Gly Asn Asn Val Ile Ser Asn Thr Arg Phe Gln Tyr Leu 
                645                 650                 655     


Ile Arg Tyr Gly Asn Pro Gln Lys Leu His Thr Leu Ser Gln Asn Glu 
            660                 665                 670         


Thr Val Val Arg Phe Val Leu Ser Arg Ile Ala Lys Asn Gln Arg Val 
        675                 680                 685             


Gln Gly Met Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys 
    690                 695                 700                 


Gly Gly Thr Asn Ser Trp Ser Val Ser Glu Glu Glu Lys Ile Asn Phe 
705                 710                 715                 720 


Leu Cys Lys Ile Leu Thr Asn Met Ser Tyr Asp Gln Phe Gln Asp Val 
                725                 730                 735     


Lys Gln Ser Gly Ala Glu Ile Thr Ala Glu Glu Lys Arg Lys Lys Glu 
            740                 745                 750         


Arg Tyr Lys Ala Ile Ile Ser Leu Tyr Leu Thr Val Leu Tyr Gln Leu 
        755                 760                 765             


Ile Lys Asn Leu Val Asn Ile Asn Ala Arg Tyr Ile Ile Ala Phe His 
    770                 775                 780                 


Cys Leu Glu Arg Asp Ala Ile Leu Tyr Ser Ser Lys Phe Asn Thr Ser 
785                 790                 795                 800 


Ile Asn Leu Lys Lys Arg Tyr Thr Ala Leu Thr Glu Met Ile Leu Gly 
                805                 810                 815     


Tyr Glu Thr Asp Glu Lys Ala Arg Arg Lys Asp Thr Arg Thr Val Tyr 
            820                 825                 830         


Glu Lys Ala Glu Ala Ala Lys Asn Arg His Leu Lys Asn Val Lys Trp 
        835                 840                 845             


Asn Cys Lys Thr Arg Glu Asn Leu Glu Asn Ala Asp Lys Asn Ala Ile 
    850                 855                 860                 


Val Ala Phe Arg Asn Ile Val Ala His Leu Trp Ile Ile Arg Asp Ala 
865                 870                 875                 880 


Asp Arg Phe Ile Thr Gly Met Gly Ala Met Lys Arg Tyr Phe Asp Cys 
                885                 890                 895     


Tyr His Tyr Leu Leu Gln Arg Glu Leu Gly Tyr Ile Leu Glu Lys Ser 
            900                 905                 910         


Asn Gln Gly Ser Glu Tyr Thr Lys Lys Ser Leu Glu Lys Val Gln Gln 
        915                 920                 925             


Tyr His Ser Tyr Cys Lys Asp Phe Leu His Met Leu Cys Leu Pro Phe 
    930                 935                 940                 


Ala Tyr Cys Ile Pro Arg Tyr Lys Asn Leu Ser Ile Ala Glu Leu Phe 
945                 950                 955                 960 


Asp Arg His Glu Pro Glu Ala Glu Pro Lys Glu Glu Ala Ser Ser Val 
                965                 970                 975     


Asn Asn Ser Gln Phe Ile Thr Thr 
            980                 


<210>  156
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR 1

<400>  156
actacaatcc atggttatcg tggatactaa aac                                    33


<210>  157
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR 2

<400>  157
actacaatcc acgtttatcg tggatactaa aac                                    33


<210>  158
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession): contig emb|OHBM01000764.1 (human gut metagenome assembly)


<220>
<221>  misc_feature
<222>  (1)..(222)
<223>  Xaa can be any naturally occurring amino acid

<400>  158

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Pro 
    210                 215                 220                 


Leu Gln Lys Arg Tyr Arg Tyr Leu Thr Ser Thr Asn Leu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Tyr Lys Asn Asn Leu Val Asn Lys Lys Lys Phe Asp Leu Asp 
                245                 250                 255     


Arg Val Lys Lys Ile Pro Gln Leu Ala Tyr Phe Gly Ser Ala Phe Tyr 
            260                 265                 270         


Asn Thr Pro Glu Asp Thr Ser Ala Lys Ile Thr Lys Thr Lys Ile Lys 
        275                 280                 285             


Ser Asn Glu Glu Ile Tyr Tyr Thr Phe Met Leu Leu Ser Thr Ala Arg 
    290                 295                 300                 


Asn Phe Ser Ala His Tyr Leu Asp Arg Asn Arg Ala Lys Ser Ser Asp 
305                 310                 315                 320 


Ala Glu Asp Phe Asp Gly Thr Ser Val Ile Met Tyr Asn Leu Asp Asn 
                325                 330                 335     


Glu Glu Leu Tyr Lys Lys Leu Tyr Asn Lys Lys Val His Met Ala Leu 
            340                 345                 350         


Thr Gly Met Lys Lys Val Leu Asp Ala Asn Phe Asn Lys Lys Val Glu 
        355                 360                 365             


His Leu Asn Asn Ser Phe Ile Lys Asn Ser Ala Lys Asp Phe Val Ile 
    370                 375                 380                 


Leu Cys Glu Val Leu Gly Ile Lys Ser Arg Asp Glu Lys Thr Lys Phe 
385                 390                 395                 400 


Val Lys Asp Tyr Tyr Asp Phe Val Val Arg Lys Asn Tyr Lys His Leu 
                405                 410                 415     


Gly Phe Ser Val Lys Glu Leu Arg Glu Leu Leu Phe Ala Asn His Asp 
            420                 425                 430         


Ser Asn Lys Tyr Ile Lys Glu Phe Asp Lys Ile Ser Asn Lys Lys Phe 
        435                 440                 445             


Asp Ser Val Arg Ser Arg Leu Asn Arg Leu Ala Asp Tyr Ile Ile Tyr 
    450                 455                 460                 


Asp Tyr Tyr Asn Lys Asn Asn Ala Lys Val Ser Asp Leu Val Lys Tyr 
465                 470                 475                 480 


Leu Arg Ala Ala Ala Asp Asp Glu Gln Lys Lys Lys Ile Tyr Leu Asn 
                485                 490                 495     


Glu Ser Ile Asn Leu Val Lys Ser Gly Ile Leu Glu Arg Ile Lys Lys 
            500                 505                 510         


Ile Leu Pro Lys Leu Asn Gly Lys Ile Ile Gly Asn Met Gln Pro Asp 
        515                 520                 525             


Ser Thr Ile Thr Ala Ser Met Leu His Asn Thr Gly Lys Asp Trp His 
    530                 535                 540                 


Pro Ile Ser Glu Asn Ala His Tyr Phe Thr Lys Trp Ile Tyr Thr Leu 
545                 550                 555                 560 


Thr Leu Phe Met Asp Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu 
                565                 570                 575     


Ile Asn Lys Phe Asp Asn Ile Ala Ser Phe Ile Glu Val Leu Lys Ser 
            580                 585                 590         


Gln Ser Val Cys Thr His Phe Ser Glu Glu Arg Lys Met Phe Ile Asp 
        595                 600                 605             


Ser Ala Glu Ile Cys Ser Glu Leu Ser Ala Met Asn Ser Phe Ala Arg 
    610                 615                 620                 


Met Glu Ala Pro Gly Ala Ser Ser Lys Arg Ala Met Phe Val Glu Ala 
625                 630                 635                 640 


Ala Arg Ile Leu Gly Asp Asn Arg Ser Lys Glu Glu Leu Glu Glu Tyr 
                645                 650                 655     


Phe Asp Thr Leu Phe Asp Lys Ser Ala Ser Lys Lys Glu Lys Gly Phe 
            660                 665                 670         


Arg Asn Phe Ile Arg Asn Asn Val Val Asp Ser Asn Arg Phe Lys Tyr 
        675                 680                 685             


Leu Thr Arg Tyr Thr Asp Thr Ser Ser Val Lys Ala Phe Ser Asn Asn 
    690                 695                 700                 


Lys Ala Leu Val Lys Phe Ala Ile Lys Asp Ile Pro Gln Glu Gln Ile 
705                 710                 715                 720 


Leu Arg Tyr Tyr Asn Ser Cys Phe Gly Ala Ser Glu Arg Tyr Tyr Asn 
                725                 730                 735     


Asp Gly Met Ser Asp Lys Leu Val Glu Ala Ile Gly Lys Ile Asn Leu 
            740                 745                 750         


Met Gln Phe Asn Gly Val Ile Gln Gln Ala Asp Arg Asn Met Leu Pro 
        755                 760                 765             


Glu Glu Lys Lys Lys Ala Asn Ala Gln Lys Glu Lys Tyr Lys Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Leu Thr Val Cys Tyr Leu Phe Phe Lys Asn Leu Val 
785                 790                 795                 800 


Tyr Val Asn Ser Arg Tyr Tyr Ser Ala Phe Tyr Asn Leu Glu Lys Asp 
                805                 810                 815     


Arg Ser Leu Phe Glu Ile Asn Gly Glu Leu Lys Pro Thr Gly Lys Phe 
            820                 825                 830         


Asp Glu Gly His Tyr Thr Gly Leu Val Lys Leu Phe Ile Asp Asn Gly 
        835                 840                 845             


Trp Ile Asn Pro Arg Ala Ser Ala Tyr Leu Thr Val Asn Leu Ala Asn 
    850                 855                 860                 


Ser Asp Glu Thr Ala Ile Arg Thr Phe Arg Asn Thr Ala Glu His Leu 
865                 870                 875                 880 


Glu Ala Leu Arg Asn Ala Asp Lys Tyr Leu Asn Asp Leu Lys Gln Phe 
                885                 890                 895     


Asp Ser Tyr Phe Glu Ile Tyr His Tyr Ile Thr Gln Arg Asn Ile Lys 
            900                 905                 910         


Glu Lys Cys Glu Met Leu Lys Glu Gln Thr Val Lys Tyr Asn Asn Asp 
        915                 920                 925             


Leu Leu Lys Tyr His Gly Tyr Ser Lys Asp Phe Val Lys Ala Leu Cys 
    930                 935                 940                 


Val Pro Phe Gly Tyr Asn Leu Pro Arg Phe Lys Asn Leu Ser Ile Asp 
945                 950                 955                 960 


Ala Leu Phe Asp Lys Asn Asp Lys Arg Glu Lys Leu Lys Lys Gly Phe 
                965                 970                 975     


Glu Asp 
        


<210>  159
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  159
gaactacagc cctccttaaa tggggggttc taaaac                                 36


<210>  160
<211>  1023
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession): contig emb|OHCP01000044.1 (human gut metagenome assembly)

<400>  160

Met Ala Lys Lys Ile Thr Ala Lys Gln Lys Arg Glu Glu Lys Glu Arg 
1               5                   10                  15      


Leu Asn Lys Gln Lys Trp Ala Lys Asn Asp Ser Val Ile Ile Val Pro 
            20                  25                  30          


Glu Thr Lys Glu Glu Ile Lys Thr Gly Glu Ile Gln Asp Asn Asn Arg 
        35                  40                  45              


Lys Arg Ser Arg Gln Lys Ser Gln Ala Lys Ala Met Gly Leu Lys Ala 
    50                  55                  60                  


Val Leu Ser Phe Asp Asn Lys Ile Ala Ile Ala Ser Phe Val Ser Ser 
65                  70                  75                  80  


Lys Asn Ala Lys Ser Ser His Ile Glu Arg Ile Thr Asp Lys Glu Gly 
                85                  90                  95      


Thr Thr Ile Ser Val Asn Ser Lys Met Phe Glu Ser Ser Val Asn Lys 
            100                 105                 110         


Arg Asp Ile Asn Ile Glu Lys Arg Ile Thr Ile Glu Glu Pro Gln Gln 
        115                 120                 125             


Asp Gly Thr Ile Lys Lys Glu Glu Lys Gly Val Lys Ser Thr Thr Cys 
    130                 135                 140                 


Asn Pro Tyr Phe Lys Val Gly Gly Lys Asp Tyr Ile Gly Ile Lys Glu 
145                 150                 155                 160 


Ile Ala Glu Glu His Phe Phe Gly Arg Ala Phe Pro Asn Glu Asn Leu 
                165                 170                 175     


Arg Val Gln Ile Ala Tyr Asn Ile Phe Asp Val Gln Lys Ile Leu Gly 
            180                 185                 190         


Thr Phe Val Asn Asn Ile Ile Tyr Ser Phe Tyr Asn Leu Ser Arg Asp 
        195                 200                 205             


Glu Val Gln Ser Asp Asn Asp Val Ile Gly Met Leu Tyr Ser Ile Ser 
    210                 215                 220                 


Asp Tyr Asp Arg Gln Lys Glu Thr Glu Thr Phe Leu Gln Ala Lys Ser 
225                 230                 235                 240 


Leu Leu Lys Gln Thr Glu Ala Tyr Tyr Ala Tyr Phe Asp Asp Val Phe 
                245                 250                 255     


Lys Lys Asn Lys Lys Pro Asp Lys Asn Lys Glu Gly Asp Asn Ser Lys 
            260                 265                 270         


Gln Tyr Gln Glu Asn Leu Arg His Asn Phe Asn Ile Leu Arg Val Leu 
        275                 280                 285             


Ser Phe Leu Arg Gln Ile Cys Met His Ala Glu Val His Val Ser Asp 
    290                 295                 300                 


Asp Glu Gly Cys Thr Arg Thr Gln Asn Tyr Thr Asp Ser Leu Glu Ala 
305                 310                 315                 320 


Leu Phe Asn Ile Ser Lys Ala Phe Gly Lys Lys Met Pro Glu Leu Lys 
                325                 330                 335     


Thr Leu Ile Asp Asn Ile Tyr Ser Lys Gly Ile Asn Ala Ile Asn Asp 
            340                 345                 350         


Glu Phe Val Lys Asn Gly Lys Asn Asn Leu Tyr Ile Leu Ser Lys Val 
        355                 360                 365             


Tyr Pro Asn Glu Lys Arg Glu Val Leu Leu Arg Glu Tyr Tyr Asn Phe 
    370                 375                 380                 


Val Val Cys Lys Glu Gly Ser Asn Ile Gly Ile Ser Thr Arg Lys Leu 
385                 390                 395                 400 


Lys Glu Thr Met Ile Ala Gln Asn Met Pro Ser Leu Lys Glu Glu Asn 
                405                 410                 415     


Thr Tyr Arg Asn Lys Leu Tyr Thr Val Met Asn Phe Ile Leu Val Arg 
            420                 425                 430         


Glu Leu Lys Asn Cys Ala Thr Ile Arg Glu Gln Met Ile Lys Glu Leu 
        435                 440                 445             


Arg Ala Asn Met Asp Glu Glu Glu Gly Arg Asp Arg Ile Tyr Ser Lys 
    450                 455                 460                 


Tyr Ala Lys Glu Ile Tyr Leu Tyr Val Lys Asp Lys Leu Lys Leu Met 
465                 470                 475                 480 


Leu Asn Val Phe Lys Glu Glu Ala Glu Gly Ile Ile Ile Pro Gly Lys 
                485                 490                 495     


Glu Asp Pro Val Lys Phe Ser His Gly Lys Leu Asp Lys Lys Glu Ile 
            500                 505                 510         


Glu Ser Phe Cys Leu Thr Thr Lys Asn Thr Glu Asp Ile Thr Lys Val 
        515                 520                 525             


Ile Tyr Phe Leu Cys Lys Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu 
    530                 535                 540                 


Cys Cys Ala Met Met Asn Lys Leu Asp Gly Ile Ser Asp Leu Ile Glu 
545                 550                 555                 560 


Thr Ala Lys Gln Cys Gly Glu Asp Val Glu Phe Val Asp Gln Phe Lys 
                565                 570                 575     


Cys Leu Ser Lys Cys Ala Thr Met Ser Asn Gln Ile Arg Ile Val Lys 
            580                 585                 590         


Asn Ile Ser Arg Met Lys Lys Glu Met Thr Ile Asp Asn Asp Thr Ile 
        595                 600                 605             


Phe Leu Asp Ala Leu Glu Leu Leu Gly Arg Lys Ile Glu Lys Tyr Gln 
    610                 615                 620                 


Lys Asp Lys Asn Gly Asp Tyr Val Lys Asp Glu Lys Gly Lys Lys Val 
625                 630                 635                 640 


Tyr Thr Lys Asp Tyr Asn Asn Phe Gln Asp Met Phe Phe Glu Gly Lys 
                645                 650                 655     


Asn His Arg Val Arg Asn Phe Val Ser Asn Asn Val Ile Lys Ser Lys 
            660                 665                 670         


Trp Phe Ser Tyr Val Val Arg Tyr Asn Lys Pro Ala Glu Cys Gln Ala 
        675                 680                 685             


Leu Met Arg Asn Ser Lys Leu Val Lys Phe Ala Leu Asp Glu Leu Pro 
    690                 695                 700                 


Asp Ser Gln Ile Glu Lys Tyr Tyr Ile Ser Val Phe Gly Glu Lys Ser 
705                 710                 715                 720 


Ser Ser Ser Asn Glu Glu Met Arg Arg Glu Leu Leu Lys Lys Leu Cys 
                725                 730                 735     


Asp Phe Ser Val Arg Gly Phe Leu Asp Glu Ile Val Leu Leu Ser Glu 
            740                 745                 750         


Asp Glu Met Lys Gln Lys Asp Lys Phe Ser Glu Lys Glu Lys Lys Lys 
        755                 760                 765             


Ser Leu Ile Arg Leu Tyr Leu Thr Ile Val Tyr Leu Ile Thr Lys Ser 
    770                 775                 780                 


Met Val Lys Ile Asn Thr Arg Phe Ser Ile Ala Cys Ala Thr Tyr Glu 
785                 790                 795                 800 


Arg Asp Tyr Ile Leu Leu Cys Gln Ser Glu Lys Ala Glu Arg Ala Trp 
                805                 810                 815     


Glu Lys Gly Ala Thr Ala Phe Ala Leu Thr Arg Lys Phe Leu Asn His 
            820                 825                 830         


Asp Lys Pro Thr Phe Glu Gln Tyr Tyr Thr Arg Glu Arg Glu Ile Ser 
        835                 840                 845             


Ala Met Pro Gln Glu Lys Arg Lys Glu Leu Arg Lys Glu Asn Asp Gln 
    850                 855                 860                 


Leu Leu Lys Lys Thr His Tyr Ser Lys His Ala Tyr Cys Tyr Ile Val 
865                 870                 875                 880 


Asp Asn Val Asn Asn Leu Thr Gly Ala Val Ala Asn Asp Asn Gly Arg 
                885                 890                 895     


Gly Leu Pro Cys Leu Ser Glu Lys Asn Asp Asn Ala Asn Leu Phe Leu 
            900                 905                 910         


Glu Met Arg Asn Lys Ile Val His Leu Asn Val Val His Asp Met Val 
        915                 920                 925             


Lys Tyr Ile Asn Glu Ile Lys Asn Ile Thr Ser Tyr Tyr Ala Phe Phe 
    930                 935                 940                 


Cys Tyr Val Leu Gln Arg Met Ile Ile Gly Asn Asn Ser Asn Glu Gln 
945                 950                 955                 960 


Asn Lys Phe Lys Ala Lys Tyr Ser Lys Thr Leu Gln Glu Phe Gly Thr 
                965                 970                 975     


Tyr Ser Lys Asp Leu Met Trp Val Leu Asn Leu Pro Phe Ala Tyr Asn 
            980                 985                 990         


Leu Pro Arg Tyr Lys Asn Leu Ser  Asn Glu Gln Leu Phe  Tyr Asp Glu 
        995                 1000                 1005             


Glu Glu  Arg Met Glu Lys Ile  Val Gly Arg Lys Asn  Asp Ser Arg 
    1010                 1015                 1020             


<210>  161
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  161
gtactaaagc ccgctagtat agacgggttc taagac                                 36


<210>  162
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession): contig emb|OGDF01008514.1| (human gut metagenome assembly)

<400>  162

Met Thr Glu Thr Lys Pro Lys Arg Glu Asp Ile Ala Lys Thr Pro Ala 
1               5                   10                  15      


Ala Lys Ser Arg Ser Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Val 
            20                  25                  30          


Asn Gly Ser Val Leu Leu Thr Ser Phe Gly Arg Gly Asn Asp Ala Val 
        35                  40                  45              


Pro Glu Lys Leu Ile Thr Glu Lys Ala Val Ser Glu Ile Asn Thr Val 
    50                  55                  60                  


Lys Pro Arg Phe Ser Val Glu Lys Pro Ala Thr Ser Tyr Ser Ser Ser 
65                  70                  75                  80  


Phe Gly Ile Lys Ser His Ile Ser Ala Thr Ala Asp Asn Pro Leu Ala 
                85                  90                  95      


Gly Arg Ala Pro Val Gly Glu Asp Ala Ile His Ala Lys Glu Val Leu 
            100                 105                 110         


Glu Gln Arg Val Phe Gly Lys Thr Phe Ser Asp Asp Asn Ile His Ile 
        115                 120                 125             


Gln Leu Ile Tyr Asn Ile Leu Asp Ile Arg Lys Ile Leu Ser Thr Tyr 
    130                 135                 140                 


Ala Asn Asn Val Val Phe Thr Ile Asn Ser Met Arg Arg Leu Asp Glu 
145                 150                 155                 160 


Tyr Asp Arg Glu Gln Asp Tyr Leu Gly Tyr Leu Tyr Thr Gly Asn Ser 
                165                 170                 175     


Tyr Glu Arg Leu Leu Asp Ile Ala Asp Lys Tyr Ala Val Asp Gly Glu 
            180                 185                 190         


Asp Trp Arg Asn Thr Ala Ala Gly Ile Ser Asn Asp Phe Glu Lys Lys 
        195                 200                 205             


Gln Phe Gln Thr Ile Asn Gly Phe Trp Asp Leu Leu Asp Met Ile Glu 
    210                 215                 220                 


Pro Tyr Met Cys Tyr Phe Ser Glu Ala Phe Phe Cys Glu Thr Thr Val 
225                 230                 235                 240 


Lys Asp Pro Asp Ser Gly Arg Ile Val Pro Cys Leu Glu Gln Arg Ser 
                245                 250                 255     


Asp Gly Asp Ile Tyr Asn Ile Leu Arg Ile Leu Ser Ile Val Arg Gln 
            260                 265                 270         


Thr Cys Met His Asp Asn Ala Ser Met Arg Thr Val Met Phe Thr Leu 
        275                 280                 285             


Gly Gln Asn Ser Val Arg Asp Arg Lys Asn Gly Phe Asp Glu Leu Ala 
    290                 295                 300                 


Glu Leu Leu Asp Tyr Leu Tyr Asp Glu Lys Ile Asp Ile Val Asn Arg 
305                 310                 315                 320 


Asp Phe Leu Arg Asn Gln Lys Asn Asn Ile Glu Leu Leu Ser Arg Ile 
                325                 330                 335     


Tyr Gly Ser Ser Ala Asp Ser Pro Glu Arg Asp Arg Leu Val Gln Asn 
            340                 345                 350         


Phe Tyr Asp Phe Arg Val Leu Ser Gln Asp Lys Asn Leu Gly Phe Ser 
        355                 360                 365             


Ile Lys Lys Leu Arg Glu Lys Leu Leu Asp Ser Pro Ala Leu Ser Val 
    370                 375                 380                 


Val Arg Ser Lys Lys Tyr Asp Thr Met Arg Ser Lys Ile Tyr Ser Leu 
385                 390                 395                 400 


Ile Asp Phe Met Ile Tyr Arg Lys Phe Ser Glu Asn His Val Ala Val 
                405                 410                 415     


Asp Asp Phe Val Glu Glu Leu Arg Ser Leu Leu Thr Glu Asp Glu Lys 
            420                 425                 430         


Glu Ser Ala Tyr Ser Arg Trp Ala Glu Thr Leu Ile Asn Asp Gly Phe 
        435                 440                 445             


Ala Gln Glu Ile Leu Val Lys Leu Leu Pro Gln Thr Asp Pro Ala Val 
    450                 455                 460                 


Ile Gly Lys Ile Lys Gly Lys Lys Leu Leu Asn Asp Ser Ile Ala Gly 
465                 470                 475                 480 


Ile Lys Leu Lys Lys Asp Ala Ser Phe Phe Thr Lys Ile Ile Asn Val 
                485                 490                 495     


Leu Cys Met Phe Gln Asp Gly Lys Glu Ile Asn Glu Leu Val Ser Ser 
            500                 505                 510         


Leu Val Asn Lys Phe Ala Asn Ile Gln Ser Phe Val Asp Val Met Arg 
        515                 520                 525             


Ser Gln Gly Ile Asp Ser Gly Phe Thr Ala Asp Tyr Ala Met Phe Ala 
    530                 535                 540                 


Glu Ser Gly Arg Ile Ser Arg Glu Leu His Ile Leu Lys Gly Ile Ala 
545                 550                 555                 560 


Arg Met Gln His Ser Ile Ala Gly Leu Gly Asp Val Lys Ile Tyr Gly 
                565                 570                 575     


Ser Asp Asp Lys Phe His Gly Val Ser Arg Arg Val Tyr Thr Asp Ala 
            580                 585                 590         


Ala Tyr Ile Leu Gly Phe Gly Glu Arg Ser Glu Asp Asn Asp Gly Tyr 
        595                 600                 605             


Val Asp Asp Tyr Val Ser Ser Lys Leu Leu Gly Gly Ala Asp Lys Asn 
    610                 615                 620                 


Leu Arg Asn Phe Ile Thr Asn Asn Val Ile Lys Asn Arg Arg Phe Leu 
625                 630                 635                 640 


Tyr Thr Val Arg Tyr Met Asn Pro Lys Arg Ala Lys Lys Leu Val Gln 
                645                 650                 655     


Asn Asp Ala Leu Val Val Leu Ala Leu Ser Gly Ile Pro Glu Thr Gln 
            660                 665                 670         


Ile Asp Arg Tyr Tyr Lys Ser Cys Ile Glu Lys Arg Ser Phe Asn Pro 
        675                 680                 685             


Asp Leu Asn Glu Lys Ile Ala Ala Leu Ser Glu Met Ile Thr Thr Leu 
    690                 695                 700                 


Lys Ile Asp Asp Phe Glu Asp Val Lys Gln Asn Pro Glu Lys Asn Ala 
705                 710                 715                 720 


Asn Tyr Glu Ala Lys Lys Asn Gln Arg Ile Ser Lys Glu Arg Tyr Lys 
                725                 730                 735     


Ala Cys Ile Gly Leu Tyr Leu Thr Val Leu Tyr Leu Ile Cys Lys Asn 
            740                 745                 750         


Leu Val Lys Ile Asn Ala Arg Tyr Ser Ile Ala Ile Gly Cys Leu Glu 
        755                 760                 765             


Arg Asp Thr Gln Leu His Gly Val Asp Phe Lys Gly Ala Ala Tyr Met 
    770                 775                 780                 


Thr Arg Asp Val Phe Ile Ala Lys Gly Trp Ile Asn Pro Lys Lys Pro 
785                 790                 795                 800 


Thr Val Lys Ser Ile Lys Glu Gln Tyr Ala Phe Leu Thr Pro Tyr Ile 
                805                 810                 815     


Phe Thr Thr Tyr Arg Asn Met Ile Ala His Leu Ala Ala Val Thr Asn 
            820                 825                 830         


Ala Tyr Lys Tyr Ile Pro Gln Met Asp Arg Phe Lys Ser Trp Phe His 
        835                 840                 845             


Leu Tyr His Thr Val Ile Gln His Ser Leu Ile Gln Gln Tyr Glu Tyr 
    850                 855                 860                 


Asp Arg Asp Tyr Gly Arg Lys Gly Ala Pro Val Val Ser Glu Arg Val 
865                 870                 875                 880 


Leu Gln Leu Leu Glu Gln Cys Arg Glu His Ser Asn Tyr Ser Arg Asp 
                885                 890                 895     


Leu Leu His Ile Leu Asn Leu Pro Phe Gly Tyr Asn Leu Pro Arg Tyr 
            900                 905                 910         


Leu Asn Leu Ser Ser Glu Lys Tyr Phe Asp Ala Asn Ala Ile 
        915                 920                 925     


<210>  163
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  163
ctactacact ggtgcgaatt tgcactagtc taaaac                                 36


<210>  164
<211>  1030
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession): contig emb|OGPN01002610.1 (human gut metagenome assembly)

<400>  164

Met Ala Lys Lys Ile Thr Ala Lys Gln Lys Arg Glu Glu Lys Glu Arg 
1               5                   10                  15      


Leu Asn Lys Gln Lys Trp Ala Lys Gln Asp Thr Pro Val Val Pro Lys 
            20                  25                  30          


Ser Lys Thr Glu Glu Lys Pro Val Ala Ala Ser Asp Asp Lys Leu Leu 
        35                  40                  45              


Lys Thr Thr Gln Val Lys Lys Val Gln Thr Lys Ser Lys Ala Lys Ala 
    50                  55                  60                  


Met Gly Leu Lys Thr Val Leu Ser Phe Asp Asp Lys Ile Ala Ile Ala 
65                  70                  75                  80  


Ser Phe Val Asn Asp Lys Lys Thr Lys Leu Pro His Ile Glu Arg Ile 
                85                  90                  95      


Thr Asp Lys Ser Gly Thr Thr Ile His Glu Asn Ala Arg Met Phe Asp 
            100                 105                 110         


Ser Ser Val Asp Glu Gln Asn Val Asn Ile Glu Lys Arg Met Thr Ile 
        115                 120                 125             


Glu Glu Lys Gln Asn Asp Gly Thr Phe Lys Lys Asp Glu Lys Asp Val 
    130                 135                 140                 


Lys Ala Thr Ile Cys Asn Pro Tyr Phe Lys Thr Cys Gly Lys Asp Tyr 
145                 150                 155                 160 


Ile Gly Ile Lys Asp Val Ala Glu Lys Tyr Phe Phe Gly Lys Thr Phe 
                165                 170                 175     


Pro Asn Glu Asn Leu Arg Val Gln Ile Ala Tyr Asn Val Phe Asp Ile 
            180                 185                 190         


Gln Lys Ile Leu Gly Thr Tyr Val Asn Asn Ile Ile Tyr Ser Phe Tyr 
        195                 200                 205             


Asn Leu Arg Arg Asp Gly Lys Ser Asp Val Asp Ile Ile Gly Ser Leu 
    210                 215                 220                 


Tyr Ala Phe Ala Asp Phe Asp Asn Gln Leu Lys Asp Lys Pro Ala Phe 
225                 230                 235                 240 


Arg Glu Ala Lys Asp Leu Leu Lys Asn Thr Glu Ala Tyr Phe Ser Tyr 
                245                 250                 255     


Phe Gly Asp Val Phe Lys Lys Ser Lys Lys Gly Lys Lys Asp Glu Asn 
            260                 265                 270         


Asn Glu Asp Tyr Glu Lys Asn Leu Arg His Asn Phe Asn Val Leu Arg 
        275                 280                 285             


Val Leu Ser Phe Leu Arg Gln Ile Cys Thr His Ala Tyr Val Lys Cys 
    290                 295                 300                 


Thr Gly Gly Ala Lys Asn Asn Gly Asp Ser Thr Lys Val Glu Ala Glu 
305                 310                 315                 320 


Ser Leu Asp Ala Leu Phe Asn Ile Thr Glu Tyr Phe Ala Lys Thr Ala 
                325                 330                 335     


Pro Glu Leu Ser Lys Thr Ile Asn Glu Ile Tyr Lys Glu Gly Ile Asp 
            340                 345                 350         


Arg Ile Asn Asn Asp Phe Val Thr Asn Gly Lys Asn Asn Leu Tyr Ile 
        355                 360                 365             


Leu Ser Lys Val Tyr Pro Asp Met Gln Arg Asn Glu Leu Val Lys Lys 
    370                 375                 380                 


Tyr Tyr Gln Phe Val Val Cys Lys Glu Gly Asn Asn Val Gly Ile Asn 
385                 390                 395                 400 


Thr Arg Lys Leu Lys Glu Ser Ile Ile Ser Gln His Pro Trp Ile Thr 
                405                 410                 415     


Thr Pro Gln Asp Asn Asn Lys Ala Asn Asp Tyr Glu Ser Cys Arg His 
            420                 425                 430         


Lys Leu Tyr Thr Ile Met Cys Phe Ile Leu Val Ala Glu Leu Asp Ala 
        435                 440                 445             


His Glu Ser Ile Arg Asp Asn Met Val Ala Glu Leu Arg Ala Asn Met 
    450                 455                 460                 


Asp Gly Asp Asp Gly Arg Asp Ala Ile Tyr Glu Lys Tyr Ala Lys Asp 
465                 470                 475                 480 


Ile Tyr His Ile Val Lys Asp Lys Leu Leu Ala Met Gln Lys Val Phe 
                485                 490                 495     


Asp Glu Glu Leu Val Pro Val Lys Val Glu Gly Lys Asn Asp Pro Gln 
            500                 505                 510         


Gln Phe Thr His Gly Lys Leu Gly Lys Lys Glu Ile Glu Ser Phe Cys 
        515                 520                 525             


Leu Ser Asp Lys Asn Thr Ser Asp Ile Ala Lys Val Val Tyr Phe Leu 
    530                 535                 540                 


Cys Asn Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu Cys Cys Ala Met 
545                 550                 555                 560 


Met Asn Lys Phe Asp Gly Ile Gly Asp Leu Ile Asp Thr Ala Lys Gln 
                565                 570                 575     


Cys Gly Glu Glu Val Lys Phe Ile Glu Glu Phe Ala Cys Leu Ser Asn 
            580                 585                 590         


Cys Arg Lys Ile Thr Asn Asp Ile Arg Val Ala Lys Ser Ile Ser Lys 
        595                 600                 605             


Met Lys Asn Lys Val Asn Ile Asp Asn Asp Ile Ile Tyr Leu Asp Ala 
    610                 615                 620                 


Ile Glu Leu Leu Gly Arg Lys Ile Glu Lys Tyr Gln Lys Asp Glu Asn 
625                 630                 635                 640 


Gly Lys Ile Leu Leu Gly Thr Asp Gly Lys Arg Leu Tyr Thr Gln Glu 
                645                 650                 655     


Tyr Lys Tyr Phe Asn Asp Met Phe Phe Asn Ala Gly Asn His Lys Val 
            660                 665                 670         


Arg Asn Phe Ile Ala Asn Asn Val Met Gln Ser Lys Trp Phe Phe Tyr 
        675                 680                 685             


Val Val Arg Tyr Asn Lys Pro Ala Glu Cys Gln Ile Ile Met Arg Asn 
    690                 695                 700                 


Lys Thr Leu Val Lys Phe Thr Leu Asp Asp Leu Pro Asp Met Gln Ile 
705                 710                 715                 720 


Gln Arg Tyr Tyr Ser Ser Val Phe Gly Asp Asn Asn Met Pro Ala Val 
                725                 730                 735     


Asp Glu Met Arg Lys Arg Leu Leu Asp Lys Ile Asn Gln Phe Ser Val 
            740                 745                 750         


Arg Gly Phe Leu Asp Glu Leu Asp Glu Ile Val Leu Met Ser Asp Glu 
        755                 760                 765             


Glu Ser Lys Arg Asn Lys Ser Ser Glu Lys Glu Gln Lys Lys Ser Leu 
    770                 775                 780                 


Ile Arg Leu Tyr Leu Thr Ile Ala Tyr Leu Ile Thr Lys Ser Met Val 
785                 790                 795                 800 


Lys Ile Asn Thr Arg Phe Ser Ile Ala Cys Ala Met Tyr Glu Arg Asp 
                805                 810                 815     


Tyr Ala Leu Leu Cys Gln Ser Glu Met Lys Gly Gly Pro Trp Asp Gly 
            820                 825                 830         


Gly Ala Gln Ala Leu Ala Val Thr Arg Lys Phe Leu Asn His Asp Arg 
        835                 840                 845             


Glu Val Phe Asp Arg Tyr Cys Ala Arg Glu Ala Glu Ile Ala Arg Leu 
    850                 855                 860                 


Pro Ser Glu Glu Arg Lys Pro Leu Arg Lys Ala Asn Asp Lys Leu Leu 
865                 870                 875                 880 


Lys Gln Thr His Tyr Thr Asn His Ser Tyr Thr Tyr Ile Val Asn Asn 
                885                 890                 895     


Leu Asn Ser Phe Thr Asp Ile Asp Tyr Cys Ala Lys Asp Val Gly Leu 
            900                 905                 910         


Pro Ala Pro Asn Asp Lys Asn Asp Asn Ala Ser Ile Leu Gly Glu Met 
        915                 920                 925             


Arg Asn Asp Ile Ala His Leu Asn Ile Val His Asp Met Val Lys Tyr 
    930                 935                 940                 


Ile Glu Glu Leu Lys Asp Ile Ser Ser Tyr Tyr Ala Phe Tyr Cys Tyr 
945                 950                 955                 960 


Val Leu Gln Arg Arg Leu Val Gly Lys Asp Pro Asn Cys Gln Asn Lys 
                965                 970                 975     


Phe Lys Ala Lys Tyr Ala Lys Glu Leu Asn Asp Tyr Gly Thr Tyr Asn 
            980                 985                 990         


Lys Asn Leu Met Trp Met Leu Asn  Leu Pro Phe Ala Tyr  Asn Leu Pro 
        995                 1000                 1005             


Arg Tyr  Lys Asn Leu Ser Ser  Glu Phe Leu Phe Tyr  Asp Met Glu 
    1010                 1015                 1020             


Tyr Asn  Lys Lys Asp Asp Glu  
    1025                 1030 


<210>  165
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  165
gaacccgtct atactagcgg gctttagtac aaaac                                  35


<210>  166
<211>  1001
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenic hit (no protein accession): contig NFIR01000008.1  (Eubacterium sp. An3, from chicken gut metagenome)

<400>  166

Met Ala Lys Lys Leu Arg Pro Lys Glu Leu Arg Glu Lys Arg Arg Met 
1               5                   10                  15      


Ala Glu Lys Glu Glu His Lys Lys Gln Glu Lys Leu Arg Lys Glu Gln 
            20                  25                  30          


Glu Glu Leu Arg Lys Lys Gln Glu Lys Gln Arg Glu Asp Gln Lys Glu 
        35                  40                  45              


Leu Glu Lys Ile Lys Lys Glu Glu Gly Gly Glu Gly Glu Lys Lys Lys 
    50                  55                  60                  


Ser Gly Ala Lys Ala Leu Gly Leu Lys Ser Thr Phe Ile Leu Asp Arg 
65                  70                  75                  80  


Asp Glu Gln Lys Met Leu Met Thr Ser Phe Gly Arg Gly Asn Lys Ala 
                85                  90                  95      


Val Arg Asp Lys Tyr Ile Ile Gly Asp Lys Val Ser Asp Ile Asp Asp 
            100                 105                 110         


Ser Trp Glu Asn Lys Lys Ala Ala Leu Ser Val Glu Val Cys Gly Lys 
        115                 120                 125             


Ser Phe Asn Ile Ser Lys Lys Glu Asn Asp Asp Cys Glu Pro Val Lys 
    130                 135                 140                 


Val Asn Asn Pro Val Leu Ser Gly Asn Lys Lys Asp Asp Asp Leu Ile 
145                 150                 155                 160 


His Cys Arg Lys Asn Leu Glu Glu Met Tyr Phe Gly Gln Gln Phe Lys 
                165                 170                 175     


Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys 
            180                 185                 190         


Ile Leu Ala Val Gln Ile Asn Asn Ile Val Phe Ile Leu Asn Asn Leu 
        195                 200                 205             


Leu Arg Trp Ser Gly Glu Glu Glu Phe Asp Leu Ile Gly Ser Leu Gly 
    210                 215                 220                 


Val Asn His Thr Tyr Glu Glu Phe Arg Gly Arg Asn Lys Asn Tyr Gly 
225                 230                 235                 240 


Lys Phe Ser Glu Leu Ile Lys Gln Ser Gln Met Arg Tyr Phe Gly Ser 
                245                 250                 255     


Thr Phe Cys Leu Phe Asn Glu Asn Glu Glu Arg Ile Thr Ser Glu Asn 
            260                 265                 270         


Lys Lys Glu Trp Lys Arg Phe Glu Lys Lys Cys Tyr His Leu Leu Ala 
        275                 280                 285             


Val Leu Gly Met Met Arg Gln Ala Thr Ala His Gly Asp Ser Lys Arg 
    290                 295                 300                 


Arg Ala Glu Ile Tyr Lys Leu Gly Lys Glu Phe Asp Arg Leu Glu Ala 
305                 310                 315                 320 


Arg Gly Cys Arg Pro Glu Ala Arg Lys Glu Leu Asp Glu Leu Tyr Lys 
                325                 330                 335     


Lys Lys Ile His Glu Met Asn Gln Gly Phe Leu Lys Asn Ser Lys Ser 
            340                 345                 350         


Asp Ile Leu Met Leu Phe Arg Ile Tyr Asn Ala Glu Ser Lys Glu Ala 
        355                 360                 365             


Lys Arg Lys Leu Ala Gln Glu Tyr Tyr Glu Phe Ile Met Leu Lys Ser 
    370                 375                 380                 


Tyr Lys Asn Thr Gly Phe Ser Ile Lys His Leu Arg Glu Thr Met Ile 
385                 390                 395                 400 


Asp Lys Met Asp Glu Asp Lys Lys Glu Lys Leu Lys Asp Asp Lys Tyr 
                405                 410                 415     


Asn Pro Ile Arg Arg Lys Ile Tyr Arg Ile Met Asp Phe Met Ile Tyr 
            420                 425                 430         


Gln Tyr Tyr Gln Glu Pro Glu His Gln Glu Glu Ala Glu Glu Leu Val 
        435                 440                 445             


Arg Lys Leu Arg Asn Ala Glu Ile Glu Ala Lys Lys Glu Leu Ala Tyr 
    450                 455                 460                 


Arg Lys Glu Ala Glu Lys Leu Lys Lys Glu Leu Glu Lys Ile Ile Phe 
465                 470                 475                 480 


Asn Ser Val Leu Pro Ser Cys Asp Arg Ile Leu Ser Glu Met Asp Glu 
                485                 490                 495     


Arg Arg Asn Lys Lys Val Asn Gln Glu Ser Ser Asp Thr Asp Lys Glu 
            500                 505                 510         


Glu Pro Leu Asp Ser Glu Ile Ala Glu Gly Ile Thr Phe Ile Lys Glu 
        515                 520                 525             


Thr Ala His Ser Phe Ser Glu Met Ile Tyr Leu Leu Thr Val Phe Leu 
    530                 535                 540                 


Asp Gly Lys Glu Ile Asn Ile Leu Leu Thr Gln Leu Ile His Cys Phe 
545                 550                 555                 560 


Asp Asn Ile Ser Ser Phe Met Asp Thr Met Glu Glu Glu Asn Leu Leu 
                565                 570                 575     


Thr Lys Leu Lys Glu Asp Tyr Glu Ile Phe Glu Glu Ser Lys Glu Ile 
            580                 585                 590         


Ser Arg Glu Leu Arg Ile Ile Asn Ser Phe Ala Arg Met Thr Glu Pro 
        595                 600                 605             


Val Pro Lys Thr Glu Arg Ile Met Phe Ile Glu Ala Ala Gln Ile Leu 
    610                 615                 620                 


Gly Tyr Ser Asn Gly Glu Lys Glu Leu Glu Gly Tyr Val Asp Ala Leu 
625                 630                 635                 640 


Leu Asp Thr Lys Asn Lys Thr Asn Asp Lys Lys Lys Lys Gly Phe Val 
                645                 650                 655     


Arg Tyr Ile Trp Asn Asn Val Ile Lys Ser Thr Arg Phe Arg Tyr Leu 
            660                 665                 670         


Val Arg Tyr Ala Asp Pro Lys Lys Val Arg Ala Phe Ala Ala Asn Lys 
        675                 680                 685             


Lys Val Val Ala Phe Val Leu Lys Asp Ile Pro Asp Asp Gln Ile Arg 
    690                 695                 700                 


Ala Tyr Tyr Asn Ser Cys Phe Arg Gln Asn Ser Asp Ser Ser Ser Asn 
705                 710                 715                 720 


Asn Ser Asn Ala Ser Trp Asp Ala Asp Ser Asn Lys Arg Asp Ile Ser 
                725                 730                 735     


Val Ser Asp Met Arg Lys Ala Leu Thr Glu Lys Ile Thr Gly Leu Asn 
            740                 745                 750         


Phe Gly Asp Phe Glu Glu Glu Ser Lys Lys Gly Ile Arg Lys Glu Glu 
        755                 760                 765             


Ser Asp Lys Asn Ile Ile Arg Leu Tyr Leu Thr Val Leu Tyr Leu Val 
    770                 775                 780                 


Gln Lys Asn Leu Ile Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His 
785                 790                 795                 800 


Cys Ala Glu Arg Asp Glu Met Leu Tyr Asn Gly Glu Thr Ile Asp Asn 
                805                 810                 815     


Asn Lys Glu Lys Gly Ser Glu Lys Asp Trp Arg Lys Phe Ala Lys Gln 
            820                 825                 830         


Phe Ile Met Glu His Ser Pro Lys Lys Lys Val Lys Asp Tyr Leu Ala 
        835                 840                 845             


Lys Asn Phe Glu Tyr Ser Asn Lys Trp Ser Leu Lys Glu Phe Arg Asn 
    850                 855                 860                 


Ser Val Gln His Leu Asn Val Ile Arg Asp Ala His Lys Tyr Ile Lys 
865                 870                 875                 880 


Tyr Ile Asn Asp Asn Lys Asp Val Gln Ser Tyr Phe Ala Leu Tyr His 
                885                 890                 895     


Tyr Leu Val Gln Arg Tyr Ile Ser Glu Arg Ala Ala Asn Arg Thr Asp 
            900                 905                 910         


Lys Glu Ser Leu Ser Glu Gly Arg Leu Gln Tyr Tyr Leu Ser Gln Val 
        915                 920                 925             


Lys Glu Tyr Arg Thr Tyr Cys Lys Asp Phe Val Lys Ala Leu Asn Val 
    930                 935                 940                 


Pro Phe Ala Tyr Asn Leu Pro Arg Tyr Lys Asn Leu Ser Ile Asp Glu 
945                 950                 955                 960 


Leu Phe Asp Arg Asn Asn Tyr Leu Pro Asn Lys Ala Lys Lys Trp Ile 
                965                 970                 975     


Pro Glu Lys Lys Glu Asn Gly Glu Tyr Val Met Glu Asp Cys Gly Asn 
            980                 985                 990         


Lys Asp Ala Gly Gln Val Glu Asn  Ala 
        995                 1000     


<210>  167
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  167
gaactacact ctggctgaaa gtcagggtct aaaac                                  35


<210>  168
<211>  1006
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession): contig NFLV01000009.1  (Eubacterium sp. An11, from chicken gut metagenome)

<400>  168

Met Ser Lys Lys Gln Arg Pro Lys Asp Ile Arg Lys Arg Gln Glu Glu 
1               5                   10                  15      


Glu Lys Arg Glu Lys Tyr Lys Lys Gln Glu Glu Leu Arg Lys Lys Gln 
            20                  25                  30          


Glu Glu Leu Arg Lys Glu Gln Glu Gln Arg Arg Glu Asp Gln Lys Glu 
        35                  40                  45              


Leu Glu Lys Ile Lys Lys Glu Val Gly Glu Glu Gly Glu Lys Lys Lys 
    50                  55                  60                  


Ser Arg Ala Lys Ala Leu Gly Leu Lys Ser Thr Phe Ile Leu Asp Arg 
65                  70                  75                  80  


Asp Glu Gln Lys Val Leu Met Thr Ser Phe Gly Gln Gly Asn Lys Ala 
                85                  90                  95      


Val Arg Asp Lys Tyr Ile Ile Gly Asp Lys Val Ser Asp Ile Asn Asp 
            100                 105                 110         


Asp Arg Lys Asn Lys Lys Ala Ala Leu Leu Val Glu Val Cys Gly Lys 
        115                 120                 125             


Ser Phe Asn Ile Ser Lys Lys Glu Asn Asp Asp Cys Asp Pro Val Lys 
    130                 135                 140                 


Val Asn Asn Pro Val Val Ser Arg Asn Lys Lys Asp Asp Asp Leu Ile 
145                 150                 155                 160 


His Cys Arg Lys Lys Leu Glu Glu Leu Tyr Phe Gly Glu Gln Phe Lys 
                165                 170                 175     


Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys 
            180                 185                 190         


Ile Leu Ala Val Gln Val Asn Asn Ile Val Phe Ala Leu Asn Asn Leu 
        195                 200                 205             


Leu Ser Trp Ser Gly Glu Glu Lys Phe Asp Leu Ile Gly Tyr Leu Gly 
    210                 215                 220                 


Val Asn Asp Thr Tyr Glu Lys Phe Arg Asp Ala Lys Gly Lys Arg Lys 
225                 230                 235                 240 


Gly Leu Tyr Glu Lys Phe Ser Thr Leu Ile Glu Lys Lys Arg Met Arg 
                245                 250                 255     


Tyr Phe Gly Ser Thr Phe Tyr Pro Leu Asn Glu Lys Gly Glu Glu Ile 
            260                 265                 270         


Thr Ser Asn Asp Lys Lys Glu Trp Glu Gln Phe Glu Lys Lys Cys Tyr 
        275                 280                 285             


His Leu Leu Ala Val Leu Gly Met Met Arg Gln Ala Thr Ala His Gly 
    290                 295                 300                 


Asp Ser Lys Arg Arg Ala Glu Ile Tyr Lys Leu Gly Lys Glu Phe Asp 
305                 310                 315                 320 


Lys Ser Glu Ala Arg Gly Cys Arg Gln Glu Ala Arg Lys Glu Leu Asp 
                325                 330                 335     


Asp Leu Tyr Arg Lys Lys Ile His Glu Met Asn Gln Ser Phe Leu Lys 
            340                 345                 350         


Asn Ser Lys Arg Asp Ile Leu Met Leu Phe Arg Ile Tyr Asp Ala Glu 
        355                 360                 365             


Ser Lys Glu Ala Lys Arg Lys Leu Ala Gln Glu Tyr Tyr Glu Phe Ile 
    370                 375                 380                 


Met Leu Lys Ser Tyr Lys Asn Thr Gly Phe Ser Ile Lys His Leu Arg 
385                 390                 395                 400 


Glu Thr Val Ile Asp Lys Met Asp Glu Asp Ile Lys Glu Lys Ile Lys 
                405                 410                 415     


Asp Asp Lys Tyr Asn Pro Ile Arg Arg Lys Leu Tyr Arg Ile Met Asp 
            420                 425                 430         


Phe Val Ile Tyr Gln Tyr Tyr Gln Glu Ser Glu Gln Gln Glu Glu Ala 
        435                 440                 445             


Met Glu Leu Val Arg Lys Leu Arg Asn Ala Glu Thr Lys Val Glu Lys 
    450                 455                 460                 


Glu Leu Thr Tyr Arg Lys Glu Ala Glu Lys Leu Lys Glu Glu Leu Glu 
465                 470                 475                 480 


Lys Ile Ile Arg Asn Ser Ile Leu Ser Val Cys Asp Arg Ile Leu Ala 
                485                 490                 495     


Glu Met Asn Glu Lys Arg His Lys Lys Val Asn Gln Glu Ser Ser Asp 
            500                 505                 510         


Thr Asp Ser Glu Glu Pro Leu Asp Pro Glu Ile Ser Glu Gly Ile Thr 
        515                 520                 525             


Phe Ile Lys Glu Thr Ala His Ser Phe Ser Glu Met Ile Tyr Leu Leu 
    530                 535                 540                 


Thr Val Phe Leu Asp Gly Lys Glu Ile Asn Ile Leu Leu Thr Gln Leu 
545                 550                 555                 560 


Ile His Cys Phe Asp Asn Ile Ser Ser Phe Met Asp Thr Met Lys Glu 
                565                 570                 575     


Glu Asn Leu Leu Thr Lys Leu Lys Glu Asp Tyr Glu Ile Phe Glu Glu 
            580                 585                 590         


Ser Lys Glu Ile Ser Lys Glu Leu Arg Ile Ile Asn Ser Phe Ala Arg 
        595                 600                 605             


Met Thr Glu Pro Val Pro Lys Thr Glu Lys Thr Met Phe Ile Asp Ala 
    610                 615                 620                 


Ala Gln Ile Leu Gly Tyr Ser Asn Asp Glu Lys Glu Leu Glu Gly Tyr 
625                 630                 635                 640 


Val Asp Ala Leu Leu Asp Thr Lys Asn Lys Thr Lys Asp Lys Glu Arg 
                645                 650                 655     


Lys Gly Phe Glu Lys Tyr Ile Trp Asn Asn Val Ile Lys Ser Thr Arg 
            660                 665                 670         


Phe Arg Tyr Leu Val Arg Tyr Ala Asp Pro Lys Lys Val Arg Ala Phe 
        675                 680                 685             


Ala Ala Asn Lys Lys Val Val Ala Phe Val Leu Lys Asp Ile Pro Asp 
    690                 695                 700                 


Glu Gln Ile Lys Ala Tyr Tyr Asn Ser Cys Phe Ser Gln Asn Ser Asp 
705                 710                 715                 720 


Ser Ser Ser Asn Met Ser Ile Ala Phe Gln Asp Gly Asp Ser Asn Lys 
                725                 730                 735     


Lys Gly Thr Ser Val His Asp Met Met Arg Lys Ala Leu Thr Glu Lys 
            740                 745                 750         


Ile Thr Gly Leu Asn Phe Gly Asp Phe Glu Glu Glu Ser Lys Lys Gly 
        755                 760                 765             


Ile Arg Arg Glu Glu Ser Asp Lys Asn Ile Ile Arg Leu Tyr Leu Thr 
    770                 775                 780                 


Val Leu Tyr Leu Val Gln Lys Asn Leu Ile Tyr Val Asn Ser Arg Tyr 
785                 790                 795                 800 


Phe Leu Ala Phe His Cys Ala Glu Arg Asp Glu Val Leu Tyr Asn Gly 
                805                 810                 815     


Glu Thr Ile Asp Asn Asn Lys Glu Lys Gly Ser Glu Lys Asp Trp Lys 
            820                 825                 830         


Lys Phe Ala Lys Glu Phe Ile Ile Glu His Pro Pro Lys Lys Lys Val 
        835                 840                 845             


Lys Asp Tyr Leu Ala Lys Asn Phe Glu Tyr Ser Asn Lys Trp Ser Leu 
    850                 855                 860                 


Arg Val Phe Arg Asn Ser Val Gln His Leu Asn Val Ile Arg Asp Ala 
865                 870                 875                 880 


Tyr Lys Tyr Ile Lys Cys Ile Asp Asp Asn Lys Asp Val Gln Ser Tyr 
                885                 890                 895     


Phe Ala Leu Tyr His Tyr Leu Val Gln Arg Tyr Ile Ser Glu Met Ala 
            900                 905                 910         


Glu Asn Leu Thr Asp Lys Gly Glu Leu Ser Glu Gly Arg Leu Gln Tyr 
        915                 920                 925             


Tyr Leu Ser Gln Val Glu Asn Tyr Arg Thr Tyr Cys Lys Asp Phe Val 
    930                 935                 940                 


Lys Ala Leu Asn Val Pro Phe Ala Tyr Asn Leu Pro Arg Tyr Lys Asn 
945                 950                 955                 960 


Leu Ser Ile Asp Glu Leu Phe Asp Arg Asn Asn Tyr Leu Pro Asn Lys 
                965                 970                 975     


Ala Lys Lys Trp Ile Ser Glu Lys Lys Glu Asn Gly Glu Tyr Val Met 
            980                 985                 990         


Glu Asp Cys Gly Asn Lys Gly Ala  Gly Gln Val Glu Asn  Ala 
        995                 1000                 1005     


<210>  169
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  169
gaactacacc ctggctgaaa gtcagggtct aaaac                                  35


<210>  170
<211>  1027
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession): from contig emb|OBLI01020244 and emb|OBLI01038679 (from pig gut metagenome)

<400>  170

Met Ala Lys Lys Ile Thr Ala Lys Gln Arg Arg Glu Glu Arg Glu Arg 
1               5                   10                  15      


Gln Asn Lys Gln Lys Trp Ala Lys Lys Gln Ala Asp Ala Thr Ala Val 
            20                  25                  30          


Phe Glu Cys Glu Ala Asp Ile Lys Pro Ala Asp Ser Lys Asp Glu Asp 
        35                  40                  45              


Cys Thr Asn Ile Tyr Ile Lys Arg Glu Lys Lys Lys Thr Gln Ala Lys 
    50                  55                  60                  


Ala Met Gly Leu Lys Thr Val Leu Gly Phe Asp Asn Lys Ile Ala Ile 
65                  70                  75                  80  


Ala Ser Phe Met Ser Ser Lys Asp Ser Lys Ser Ser His Ile Glu Arg 
                85                  90                  95      


Ile Thr Asp Pro Asn Gly Lys Thr Ile Arg Glu Asp Val Arg Met Phe 
            100                 105                 110         


Asp Ser Asn Val Asp Glu Cys Ser Ile Asn Leu Glu Lys Arg Met Thr 
        115                 120                 125             


Val Glu Glu Arg Gln Lys Asp Gly Thr Ile Lys Lys Asp Glu Lys Asp 
    130                 135                 140                 


Val Lys Ser Thr Ile Cys Asn Pro Tyr Ser Asn Glu Cys Gly Lys Asp 
145                 150                 155                 160 


Tyr Ile Gly Ile Lys Ser Val Ala Glu Glu Leu Phe Phe Gly Arg Thr 
                165                 170                 175     


Phe Pro Asn Asp Asn Leu Arg Val Gln Ile Ala Tyr Asn Ile Phe Asp 
            180                 185                 190         


Ile Gln Lys Ile Leu Gly Thr Tyr Ile Asn Asn Ile Ile Tyr Ser Phe 
        195                 200                 205             


Tyr Asn Leu Ser Arg Asp Glu Ser Gln Ser Asp Asn Asp Val Ile Gly 
    210                 215                 220                 


Thr Leu Tyr Met Leu Lys Asp Phe Asp Gly Gln Lys Glu Thr Asp Thr 
225                 230                 235                 240 


Phe Arg Gln Ala Arg Ala Leu Leu Glu Arg Thr Glu Ala Tyr Tyr Ser 
                245                 250                 255     


Tyr Phe Asp Asn Val Phe Lys Lys Ile Asp Lys Asn Lys Lys Lys Ser 
            260                 265                 270         


Asp Asp Cys Lys Arg Glu Arg Asn Glu Ile Leu Arg Tyr Asn Phe Asn 
        275                 280                 285             


Val Leu Arg Val Leu Ser Phe Leu Arg Gln Ile Cys Ala His Ala Gln 
    290                 295                 300                 


Val Lys Ile Ser Asn Glu His Asp Arg Glu Lys Gly Gly Gly Leu Val 
305                 310                 315                 320 


Asp Ser Leu Asp Ala Leu Phe Asn Ile Ser Arg Phe Phe Asp Ala Val 
                325                 330                 335     


Ala Pro Glu Leu Asn Glu Val Ile Asn Ser Val Tyr Ser Lys Gly Ile 
            340                 345                 350         


Asp Asp Ile Asn Asp Asn Phe Val Lys Asn Gly Lys Asn Asn Phe Tyr 
        355                 360                 365             


Ile Leu Ser Lys Ile Tyr Pro Glu Val Ala Arg Glu Asp Leu Leu Arg 
    370                 375                 380                 


Glu Tyr Tyr Tyr Phe Val Val Ser Lys Glu Gly Asn Asn Ile Gly Ile 
385                 390                 395                 400 


Ser Thr Lys Lys Leu Lys Glu Ala Ile Ile Val Gln Asp Met Ser Tyr 
                405                 410                 415     


Ile Lys Ser Glu Asp Tyr Asp Thr Tyr Arg Asn Lys Leu Tyr Thr Val 
            420                 425                 430         


Leu Cys Phe Ile Leu Val Lys Glu Leu Asn Glu Arg Thr Thr Ile Arg 
        435                 440                 445             


Glu Gln Met Val Ala Asp Leu Arg Ala Asn Met Asn Gly Asp Ile Gly 
    450                 455                 460                 


Arg Glu Asp Ile Tyr Ser Lys Tyr Ala Lys Ile Ile Tyr Ala Gln Val 
465                 470                 475                 480 


Lys Pro Arg Phe Asp Thr Met Lys Ser Ala Phe Glu Glu Glu Ala Lys 
                485                 490                 495     


Asp Val Ile Val Pro Asp Lys Lys Lys Pro Val Lys Phe Ser His Gly 
            500                 505                 510         


Lys Leu Asp Lys Asn Glu Ile Glu Arg Phe Cys Ile Thr Ser Ala Asn 
        515                 520                 525             


Thr Asp Ser Val Ala Lys Ile Ile Tyr Phe Leu Cys Lys Phe Leu Asp 
    530                 535                 540                 


Gly Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Met Asn Lys Leu Asp 
545                 550                 555                 560 


Gly Ile Asn Asp Leu Ile Glu Thr Ala Glu Gln Cys Gly Ala Lys Val 
                565                 570                 575     


Glu Phe Val Asp Lys Phe Ser Val Leu Ser Asn Cys Glu Thr Ile Ser 
            580                 585                 590         


Asp Gln Ile Arg Ile Val Lys Ser Ile Ser Lys Met Lys Lys Glu Ile 
        595                 600                 605             


Ala Ile Asp Asn Asp Thr Ile Phe Leu Asp Ala Leu Glu Leu Leu Gly 
    610                 615                 620                 


Arg Lys Ile Asp Lys Tyr Lys Lys Asp Ala Thr Gly Lys Tyr Leu Lys 
625                 630                 635                 640 


Asp Glu Asn Gly Lys Tyr Leu Tyr Ser Lys Glu Tyr Asp Asp Phe Gln 
                645                 650                 655     


Tyr Met Phe Phe Lys Asp Ser His Arg Val Arg Asn Phe Ile Ser Asn 
            660                 665                 670         


Ser Val Ile Lys Ser Lys Trp Phe Ser Tyr Ile Val Arg Tyr Asn Gln 
        675                 680                 685             


Pro Ser Glu Cys Arg Ala Ile Met Lys Asn Lys Thr Leu Val Lys Phe 
    690                 695                 700                 


Ala Leu Asp Glu Leu Pro Asp Leu Gln Ile Gln Arg Tyr Phe Val Ala 
705                 710                 715                 720 


Leu Tyr Gly Asp Glu Asp Leu Pro Ser Tyr Gly Glu Met Arg Lys Ile 
                725                 730                 735     


Leu Leu Lys Lys Leu His Asp Phe Ser Ile Lys Gly Phe Leu Asp Glu 
            740                 745                 750         


Ile Val Leu Leu Ser Asp Leu Asp Met Glu Ser Gln Asp Lys Tyr Cys 
        755                 760                 765             


Glu Lys Glu Gln Lys Lys Ser Leu Phe Arg Leu Tyr Leu Thr Ile Ala 
    770                 775                 780                 


Tyr Leu Ile Thr Lys Ser Met Val Lys Ile Asn Thr Arg Phe Ser Ile 
785                 790                 795                 800 


Ala Cys Ala Thr Tyr Glu Arg Asp Tyr Ala Leu Leu Cys Ala Ser Asn 
                805                 810                 815     


Lys Gln Glu Arg Ala Trp Ser Ser Gly Ala Thr Ala Leu Ala Leu Thr 
            820                 825                 830         


Arg Arg Phe Leu Asn Gln Asp Lys Leu Ile Phe Glu Lys His Tyr Ala 
        835                 840                 845             


Arg Glu Gly Glu Ile Ser Lys Leu Pro Lys Glu Glu Arg Lys Ala Met 
    850                 855                 860                 


Arg Lys Val Asn Asp Gln Leu Leu Lys Arg Thr His Phe Ser Lys His 
865                 870                 875                 880 


Ser Tyr Cys Tyr Ile Val Asp Asn Val Asn Arg Leu Thr Gly Gly Glu 
                885                 890                 895     


Cys Arg Thr Asp Lys Arg Val Leu Pro Val Leu Asn Glu Lys Asn Asp 
            900                 905                 910         


Asn Ala Gly Ile Leu Leu Asp Phe Arg Lys Thr Ile Ala His Leu Asn 
        915                 920                 925             


Val Val His Lys Met Val Asp Tyr Val Asp Glu Ile Lys Gly Ile Thr 
    930                 935                 940                 


Ser Tyr Tyr Ala Phe Phe Cys Tyr Val Leu Gln Arg Met Leu Val Gly 
945                 950                 955                 960 


Asn Asn Leu Asn Glu Lys Asn Ala Ile Lys Glu Lys Tyr Ser Ala Thr 
                965                 970                 975     


Val Lys Ser Phe Gly Thr Tyr Ser Lys Asp Phe Met Trp Leu Ile Asn 
            980                 985                 990         


Leu Pro Phe Ala Tyr Asn Leu Pro  Arg Tyr Lys Asn Leu  Ser Asn Glu 
        995                 1000                 1005             


Gln Leu  Phe Tyr Asp Glu Glu  Glu Arg Asn Glu Thr  Glu Glu Gln 
    1010                 1015                 1020             


Ile Asp  Arg Leu 
    1025         


<210>  171
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Motif 1


<220>
<221>  misc_feature
<222>  (3)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(39)
<223>  Xaa can be any naturally occurring amino acid

<400>  171

Asn Val Xaa Xaa Xaa Xaa Xaa Phe Xaa Tyr Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Xaa Xaa Xaa Xaa Xaa 
        35                  


<210>  172
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Motif 2


<220>
<221>  misc_feature
<222>  (2)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (31)..(33)
<223>  Xaa can be any naturally occurring amino acid

<400>  172

Leu Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Lys Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Asp Xaa Xaa 
            20                  25                  30          


Xaa 
    


<210>  173
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Motif 3


<220>
<221>  misc_feature
<222>  (5)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Xaa can be any naturally occurring amino acid

<400>  173

Lys Glu Ile Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Ile Xaa Xaa 
            


<210>  174
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Motif 4


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  174

Pro Phe Xaa Tyr Xaa Xaa Xaa Arg Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Phe 
        


<210>  175
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession):  contig OJMM01002900 human gut metagenome sequence

<400>  175

Met Gly Lys His Leu Asn Ala Lys Gln Arg Lys Leu Glu Lys Lys Leu 
1               5                   10                  15      


Lys Asn Gln Gln Lys Asp Met Met Tyr Thr Lys Ser Thr Asp Ala Val 
            20                  25                  30          


Ser Val Pro Thr Leu Lys Ala Ala Pro Thr Lys Ala Glu Met Ser Gln 
        35                  40                  45              


Asp Thr Ala Glu Ala Ser Thr Leu Ile Thr Pro Gly Thr Leu Lys Thr 
    50                  55                  60                  


Lys Ala Lys Ala Met Gly Leu Lys Ser Thr Leu Val Phe Asp Asp Lys 
65                  70                  75                  80  


Ile Val Val Thr Ser Phe Leu Asn Ser Lys Thr Glu Glu Asn Glu Lys 
                85                  90                  95      


Cys Ala His Ile Glu Lys Ile Ala Asp Cys Asn Gly Gln Thr Ile Val 
            100                 105                 110         


Glu Arg Pro Arg Met Phe Asn Thr Ser Ile Asn Ala Lys Lys Val Asp 
        115                 120                 125             


Leu Ser Lys Asp Asn Asp Glu Thr Asn Tyr Pro Asn Pro Ala Phe Glu 
    130                 135                 140                 


Asp Cys Gly Arg Asp Tyr Ile Asn Val Lys Ser Ala Leu Glu Lys Arg 
145                 150                 155                 160 


Val Phe Gly Lys Thr Tyr Asn Lys Asp Asn Leu His Val Gln Ile Ala 
                165                 170                 175     


Tyr Asn Ile Phe Asp Ile Lys Lys Ile Ile Gly Ala Tyr Ile Asn Asn 
            180                 185                 190         


Ile Ile Tyr Ile Phe Tyr Asn Leu Gly Arg Glu Glu Tyr Asp Ala Lys 
        195                 200                 205             


Lys Asp Ile Ile Gly Thr Gln Asp Ser Ala Tyr Ile Ser Lys Ile Leu 
    210                 215                 220                 


Asn Asn Thr Ser Ala Tyr Phe Thr Tyr Phe Asp Gly Val Phe Lys Gln 
225                 230                 235                 240 


Ile Thr Asp Arg Asp Ser Asn Lys Asp Arg Glu Ile Lys Asn Ser Tyr 
                245                 250                 255     


Asn Ala Leu Val Leu Lys Val Leu Tyr Tyr Leu Arg Gln Phe Cys Met 
            260                 265                 270         


His Gly Asn Thr Tyr Thr Lys Arg Asn Glu Glu Ser Phe Leu Ser Asp 
        275                 280                 285             


Thr Ala Leu Tyr Asn Ala Lys Glu Phe Phe Ala Lys Ala Asp Pro Gln 
    290                 295                 300                 


Ile Asn Glu Leu Ile Asp Ala Val Tyr Ala Asp Gly Ile Lys Thr Ile 
305                 310                 315                 320 


Asn Ser Asp Phe Met Ala His Ala Lys Asn Asn Met Tyr Ile Ile Cys 
                325                 330                 335     


Glu Val Tyr Lys Asn Glu Ala Glu Asp Ser Leu Met Lys Glu Tyr Tyr 
            340                 345                 350         


Asp Phe Val Val Arg Lys Glu Gly Asn Asn Leu Gly Phe Asn Thr Arg 
        355                 360                 365             


Gln Leu Arg Glu Ile Leu Ile Asp Lys Tyr Val Gly Asn Leu Arg Gly 
    370                 375                 380                 


Lys Lys Tyr Asn Thr Phe Arg Asn Lys Leu Tyr Thr Val Leu Gly Phe 
385                 390                 395                 400 


Ile Leu Val Lys Glu Ile Lys Arg Asn Pro Lys Ile Gln Asp Ser Phe 
                405                 410                 415     


Ile Ala Lys Leu Arg Ala Asn Gln Asn Gly Asp Glu Gly Lys Leu Asn 
            420                 425                 430         


Ile Tyr Asn Glu Phe Ala Pro Lys Ile Trp Ser Val Val Ser Ser Lys 
        435                 440                 445             


Leu Asn Ser Ala Ile Thr Cys Phe Asp Glu Glu Ser Leu Ser Lys Phe 
    450                 455                 460                 


Lys Gly Tyr Lys Asp Ile Asp Glu Ser Leu Ile Ser Arg Tyr Gly Ile 
465                 470                 475                 480 


Thr Val Ala Asn Thr Asp Thr Leu Val Lys Ile Leu Tyr Phe Leu Cys 
                485                 490                 495     


Lys Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Ile 
            500                 505                 510         


Asn Lys Phe Asp Asn Ile Asn Asp Leu Ile Lys Thr Ala Ala Gln Cys 
        515                 520                 525             


Gly Glu Asp Ile Glu Phe Val Lys Glu Tyr Lys Leu Phe Ile Asn Ser 
    530                 535                 540                 


Asn Asp Leu Ser Asp Gln Ile Arg Ile Val Lys Ser Ile Ser Lys Met 
545                 550                 555                 560 


Lys Pro Glu Leu Ser Lys Ile Gly Glu Ala Leu Ile Leu Asp Ala Ile 
                565                 570                 575     


Asp Ile Leu Gly Tyr Lys Ile Asn Lys Tyr Lys Tyr Asp Ala Ala Gly 
            580                 585                 590         


Asn Arg Leu Val Asp Ser Asn Asn Lys Pro Val Tyr Ser Glu Glu Tyr 
        595                 600                 605             


Cys Ala Phe Lys Lys Asp Phe Phe Glu Thr Cys Glu Leu Asp Glu Phe 
    610                 615                 620                 


Gly Arg Val Lys Tyr Asn Lys Lys Gly Lys Pro Val Ile Asn His Arg 
625                 630                 635                 640 


Arg Arg Asn Phe Ile Ile Asn Asn Val Leu Ser Ser Lys Trp Phe Phe 
                645                 650                 655     


Tyr Val Ala Lys Tyr Asn Arg Pro Ser Glu Cys Gln Lys Phe Met Lys 
            660                 665                 670         


Ser Lys Lys Leu Ile Ala Leu Val Leu Lys Asp Val Pro Glu Thr Gln 
        675                 680                 685             


Ile Ala Arg Tyr Tyr Gln Ser Val Thr Gly Gly Arg Thr Gln Ala Asn 
    690                 695                 700                 


Ser Glu Ala Met Arg Met Thr Leu Ile Lys Leu Leu His Glu Phe Ser 
705                 710                 715                 720 


Ile Lys Asn Val Leu Ser Asp Val Gly Thr Met Thr Ala Ser Glu Asn 
                725                 730                 735     


Lys Arg Gln Ile Glu Asn Ser Arg Lys Glu Arg Met Lys Ala Ile Val 
            740                 745                 750         


Lys Leu Tyr Leu Thr Val Val Tyr Leu Ile Ala Lys Ser Leu Val Lys 
        755                 760                 765             


Val Asn Thr Arg Phe Ser Ile Ala Phe Ser Ala Tyr Glu Arg Asp Val 
    770                 775                 780                 


Ser Leu Leu Ala Asp Glu Asn Glu Leu Ile Ala Leu Ala Asn Asn Glu 
785                 790                 795                 800 


Asp Asp Lys Trp Lys Lys Gly Asn Tyr Val Phe Ala Leu Thr Lys His 
                805                 810                 815     


Phe Trp Asp Asn Asp Glu Pro Tyr Phe Asp Lys Tyr Asn Asn Ala Leu 
            820                 825                 830         


Gln Gln Ile Arg Ser Ile Val Asp Pro Asn Glu Arg Arg Leu Ala Tyr 
        835                 840                 845             


Arg Ala Asn Asp Lys Val Val Lys His Thr His Phe Asn Leu His Ser 
    850                 855                 860                 


Tyr Lys Tyr Val Lys His Asn Tyr Glu Glu Ile Ser Lys Ala Ser Lys 
865                 870                 875                 880 


Ile Ile Thr Ala Tyr Arg Asn Asn Val Gln His Leu Asn Val Met Asn 
                885                 890                 895     


Ser Ile Thr Lys Tyr Leu Gly Asp Ile Ser Glu Val Thr Ser Tyr Tyr 
            900                 905                 910         


Ser Leu Tyr Cys Tyr Thr Leu Gln Arg Leu Leu Leu Asp Asp Asn Asn 
        915                 920                 925             


Asn Asp Lys Phe Ala Ser Ile Lys Gly Asn Leu Arg Lys Phe Gly Ile 
    930                 935                 940                 


Tyr Asn Lys Asp Phe Met Trp Leu Leu Asn Ile Pro Phe Ala Tyr Asn 
945                 950                 955                 960 


Leu Pro Arg Tyr Lys Asn Leu Ser Asn Glu Glu Ile Phe Tyr Asp Glu 
                965                 970                 975     


Leu Gln Lys 
            


<210>  176
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Direct repeat

<400>  176
gtacaatagc cctctcgtag ttgagggctc tgagac                                 36


<210>  177
<211>  1009
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession):  contig ODAI011611274.1 gut metagenome sequence

<400>  177

Met Lys Lys Lys Ile Ser Leu Lys Glu Gln Arg Asn Thr Lys Lys Ala 
1               5                   10                  15      


Glu Asn Lys Leu Lys Tyr Gln Lys Ala Gln Ala Glu Arg Ala Ala Ala 
            20                  25                  30          


Ala Gln Gln Thr Ala Ala Gly Ala Glu Ser Glu Glu Asn Pro Cys Phe 
        35                  40                  45              


Asp Val Val Lys Asp Thr Lys Arg Lys Ala Leu Asn Pro Leu His Val 
    50                  55                  60                  


Glu Ile Glu Ala Pro Ser Ala Lys Lys Ser Ser Val Lys Ala Asn Gly 
65                  70                  75                  80  


Leu Lys Ser Leu Leu Leu Thr Asp Gly Lys Thr Val Met Thr Ser Phe 
                85                  90                  95      


Gly Arg Gly Ser Glu Ala Asn Val Glu Lys Arg Phe Asp Glu Thr Gly 
            100                 105                 110         


Thr Lys Thr Phe Asp Arg Asp Pro Glu Leu Phe Ser Ala Lys Pro Leu 
        115                 120                 125             


Glu Thr Gly Tyr Arg Ile Gln Arg Phe Asn Ala Ser Pro Lys Asp Ala 
    130                 135                 140                 


Gly Leu Ala Tyr Arg Pro Ala Gly Val Arg Pro Asp Gln Ile Gly Ala 
145                 150                 155                 160 


Lys Ala Ala Leu Glu Lys Arg Tyr Phe Gly Lys Glu Thr Pro Gly Asp 
                165                 170                 175     


Asn Ile His Val Gln Ile Ala Tyr Gln Ile Gln Asp Ile Glu Lys Leu 
            180                 185                 190         


Leu Ala Val Tyr Ile Ser Asn Ile Ile Tyr Ala Val Asn Asn Val Thr 
        195                 200                 205             


Gly Val Ser Ala Met Lys Asp Ser Lys Gly Arg Pro Val Asp Leu Leu 
    210                 215                 220                 


Gly Asp Tyr Gly Ile Leu Gly Glu Glu Gly Leu Thr Lys Arg Leu Gln 
225                 230                 235                 240 


Arg Ile Pro Glu Gln Ala Asp Glu Glu Ala Lys Ala Leu Gln Ala Phe 
                245                 250                 255     


Leu Cys Ser Glu Arg Leu Ser Tyr Phe Gly Lys Glu Phe Cys Leu Val 
            260                 265                 270         


Arg Asn Ser Pro Lys Gln Pro Asp Lys Glu Glu Lys Arg Gln Tyr Lys 
        275                 280                 285             


Leu Met Arg Val Leu Cys Leu Leu Gly Glu Leu Arg Gln Phe Leu Val 
    290                 295                 300                 


His Gly Lys Lys Lys Glu Lys Glu Phe Ala Trp Leu Tyr Arg Leu Asp 
305                 310                 315                 320 


Arg Gln Leu Ser Gln Glu Tyr Arg Lys Leu Leu Gly Glu Phe Tyr Asp 
                325                 330                 335     


Ala Gln Val Asp Lys Val Asn Lys Ser Phe Leu Thr Asn Ser Thr Val 
            340                 345                 350         


Asn Leu Glu Val Leu Phe Arg Ala Leu Lys Thr Gly Thr Asp Pro Glu 
        355                 360                 365             


Arg Lys Thr Val Thr Gln Glu Tyr Tyr Gln Phe Thr Val Arg Lys Glu 
    370                 375                 380                 


Asp Gly Asn Leu Gly Phe Ser Leu Lys Thr Leu Arg Glu Ile Leu Leu 
385                 390                 395                 400 


Ser Ala Tyr Lys His Glu Val Arg Asp Lys Glu Tyr Asp Ser Ile Arg 
                405                 410                 415     


His Lys Leu Tyr Gln Leu Phe Ser Phe Ala Leu Tyr His Tyr Tyr Lys 
            420                 425                 430         


Thr Gly Val Gly Ala Glu Arg Arg Glu Ala Phe Val Ala Lys Leu Arg 
        435                 440                 445             


Ala Val Met Thr Ala Glu Ala Lys Gln Arg Ala Tyr Ala Asp Glu Ala 
    450                 455                 460                 


Ala Glu Ile Trp Asn Asp Glu Gly Ser Gly Ile Arg Ala Ala Phe Leu 
465                 470                 475                 480 


Glu Ile Leu Glu Ala Val Asp Phe Gly Ser Ala Val Lys Gly Ile Lys 
                485                 490                 495     


Ala Arg Ser Ser Val Ala Gly Asp Lys Arg Phe Ala Glu Trp Leu Glu 
            500                 505                 510         


Glu Val Arg Ile Arg Pro Glu Gly Val Ser Cys Phe Thr Lys Leu Met 
        515                 520                 525             


Tyr Leu Leu Thr Arg Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu Leu 
    530                 535                 540                 


Thr Gly Leu Ile Asn Lys Leu Glu Asn Ile Gln Ser Phe Leu Asp Val 
545                 550                 555                 560 


Met Gln Gln Glu His Ala Glu Thr Gly Leu Ser Asp Ala Phe Ser Phe 
                565                 570                 575     


Phe Glu Tyr Ser Gly Glu Ile Ala Ala Glu Leu Arg Met Thr Arg Ser 
            580                 585                 590         


Phe Ala Arg Met Ala Ala Ala Asp Pro Glu Ala Lys Arg Phe Met Val 
        595                 600                 605             


Val Asp Gly Ala Lys Leu Leu Gly Phe Asn Pro Lys Asp Thr Glu Ser 
    610                 615                 620                 


Glu Asp Glu Gly Ile Ile Arg Ala Ile Tyr Gly Asp Ala Cys Ala Glu 
625                 630                 635                 640 


Tyr Leu Gln Phe Ser Glu Glu Glu Lys Glu Ala Phe Tyr Val Gln Glu 
                645                 650                 655     


Gly Leu Tyr Gly Lys Glu Arg Glu Lys Phe Ser Pro Tyr Ala Tyr Phe 
            660                 665                 670         


His Thr Asp Thr Ser Leu Arg Asn Phe Ile Ala Lys Asn Val Val Glu 
        675                 680                 685             


Ser Ala Arg Phe Arg Tyr Val Ile Arg Tyr Val Ser Pro Glu Ile Ala 
    690                 695                 700                 


Arg Lys Tyr Ala Arg Gln Glu Ala Leu Val Arg Phe Ala Leu His Arg 
705                 710                 715                 720 


Val Pro Leu Leu Gln Leu Arg Arg Tyr Tyr Gln Ser Cys Cys Gly Pro 
                725                 730                 735     


Lys Lys Asp Pro Asp Ala Ala Glu Cys Val Asp Phe Leu Ala Gly Val 
            740                 745                 750         


Val Asn Arg Val Asp Phe Ala Asn Phe Thr Asp Val Arg Thr Gly Asp 
        755                 760                 765             


Ser Ser Lys Ser Glu Gln Glu Lys Lys Gln Lys Tyr Gln Ala Ile Val 
    770                 775                 780                 


Gly Leu Tyr Leu Thr Val Val Tyr Trp Ile Val Lys Asn Leu Val Asn 
785                 790                 795                 800 


Val Asn Ser Arg Tyr Val Met Ala Phe His Ile Leu Glu Arg Asp Thr 
                805                 810                 815     


Val Leu Leu Glu Gly Lys Arg Leu Phe Val Gly Gly Met Lys Ala Glu 
            820                 825                 830         


Asp Pro Phe Leu Leu Thr Asp Gly Tyr Val Ser Arg Gln Asp Ala Tyr 
        835                 840                 845             


Val Arg Lys Arg Ile Gly Glu Asn Lys Arg Ala Asn Arg His Gly Leu 
    850                 855                 860                 


Asn Cys Val Leu Glu Asn Arg Asn Ala Leu Gly Ser Asp Pro Ala Ser 
865                 870                 875                 880 


Thr Asp Ala Ala Ala Ser Leu Ile Trp Ser Tyr Arg Asn Ala Ala Ala 
                885                 890                 895     


His Leu Thr Ala Val Ala Ala Ala Gln Glu Tyr Val Ser Glu Leu Arg 
            900                 905                 910         


Glu Ile His Ser Tyr Phe Glu Val Tyr His Tyr Ala Met Gln Arg Tyr 
        915                 920                 925             


Leu Lys Ser Gly Ala Glu Phe Ala Glu Leu Val Ser Lys Asn Gly Pro 
    930                 935                 940                 


Ala Ser Gly Lys Ile Ala Ala Trp Ala Asn Ala Val Asp Arg Cys His 
945                 950                 955                 960 


Ser Phe Cys Lys Asp Trp Leu Trp Leu Leu Asn Val Pro Phe Ala Tyr 
                965                 970                 975     


Asn Pro Ala Arg Tyr Lys Asn Leu Ser Ile Ala Asn Leu Phe Asp Lys 
            980                 985                 990         


Asn Glu Ala Ala Pro Val Thr Glu  Asp Ala Ser Glu Gln  Lys Glu Asp 
        995                 1000                 1005             


Glu 
    


<210>  178
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Direct repeat

<400>  178
gtactacacc cctgcagttt tgcaggggtc tgaaac                                 36


<210>  179
<211>  961
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession):  contig OIZX01000427.1

<400>  179

Met Ala Lys Lys Lys Lys Thr Ala Arg Gln Leu Arg Glu Glu Met Gln 
1               5                   10                  15      


Gln Gln Arg Lys Gln Ala Ile Gln Lys Gln Gln Glu Gln Arg Gln Glu 
            20                  25                  30          


Lys Ala Ala Ala Ala Arg Glu Thr Ala Ala Pro Glu Gln Pro Ala Ala 
        35                  40                  45              


Ala Pro Val Pro Lys Arg Gln Arg Lys Ser Leu Ala Lys Ala Ala Gly 
    50                  55                  60                  


Leu Lys Ser Asn Phe Ile Leu Asp Pro Gln Arg Arg Thr Thr Val Met 
65                  70                  75                  80  


Thr Ala Phe Gly Gln Gly Ser Thr Ala Ile Leu Glu Lys Gln Ile Val 
                85                  90                  95      


Asp Arg Ala Ile Ser Asp Leu Gln Pro Val Gln Gln Phe Gln Val Glu 
            100                 105                 110         


Pro Ala Ser Ala Ala Lys Tyr Arg Leu Lys Asn Ser Arg Val Arg Phe 
        115                 120                 125             


Pro Asn Val Thr Ala Asp Asp Pro Leu Tyr Arg Arg Lys Asp Gly Gly 
    130                 135                 140                 


Phe Val Pro Gly Met Asp Ala Leu Arg Arg Lys Asn Val Leu Glu Gln 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Ser Phe Ala Asp Asn Ile His Ile Gln Met Ile 
                165                 170                 175     


Tyr Ser Ile Leu Asp Ile His Lys Ile Leu Ala Ala Ala Ser Gly His 
            180                 185                 190         


Ile Val His Leu Leu Asn Ile Val Asn Gly Ser Lys Asp Arg Asp Phe 
        195                 200                 205             


Ile Gly Met Leu Ala Ala His Val Leu Tyr Asn Glu Leu Asn Glu Glu 
    210                 215                 220                 


Ala Lys Arg Ser Ile Ala Asp Phe Cys Lys Ser Pro Arg Leu Ile Tyr 
225                 230                 235                 240 


Tyr Ser Ala Ala Phe Tyr Glu Thr Leu Asp Asn Gly Lys Ser Glu Arg 
                245                 250                 255     


Arg Ser Asn Glu Asp Ile Phe Asn Ile Leu Ala Leu Met Thr Cys Leu 
            260                 265                 270         


Arg Asn Phe Ser Ser His His Ser Ile Ala Ile Lys Val Lys Asp Tyr 
        275                 280                 285             


Ser Ala Ala Gly Leu Tyr Asn Leu Arg Arg Leu Gly Pro Asp Met Lys 
    290                 295                 300                 


Lys Met Leu Asp Thr Phe Tyr Thr Glu Ala Phe Ile Gln Leu Asn Gln 
305                 310                 315                 320 


Ser Phe Gln Asp His Asn Thr Thr Asn Leu Thr Cys Leu Phe Asp Ile 
                325                 330                 335     


Leu Asn Ile Ser Asp Ser Ala Arg Gln Lys Gln Leu Ala Glu Glu Phe 
            340                 345                 350         


Tyr Arg Tyr Val Val Phe Lys Glu Gln Lys Asn Leu Gly Phe Ser Val 
        355                 360                 365             


Arg Lys Leu Arg Glu Glu Met Leu Leu Leu Pro Asp Ala Ala Val Ile 
    370                 375                 380                 


Ala Asp Lys Arg Tyr Asp Thr Cys Arg Ser Lys Leu Tyr Asn Leu Met 
385                 390                 395                 400 


Asp Phe Leu Ile Leu Arg Val Tyr Arg Thr Gly Arg Ala Asp Arg Cys 
                405                 410                 415     


Asp Lys Leu Pro Glu Ala Leu Arg Ala Ala Leu Thr Asp Glu Glu Lys 
            420                 425                 430         


Ala Val Val Tyr His Lys Glu Ala Leu Ser Leu Trp Asn Glu Met Arg 
        435                 440                 445             


Thr Leu Ile Leu Asp Gly Leu Leu Pro Gln Met Thr Pro Glu Asn Leu 
    450                 455                 460                 


Ser Arg Leu Ser Gly Gln Lys Arg Lys Gly Glu Leu Ser Leu Asp Asp 
465                 470                 475                 480 


Ala Met Leu Lys Glu Cys Leu Tyr Glu Pro Gly Pro Val Pro Glu Asp 
                485                 490                 495     


Ala Ala Pro Glu Glu Ala Asn Ala Glu Tyr Phe Cys Arg Met Ile Tyr 
            500                 505                 510         


Leu Ala Thr Leu Phe Met Asp Gly Lys Glu Ile Asn Thr Leu Leu Thr 
        515                 520                 525             


Thr Leu Ile Ser Lys Phe Glu Asn Ile Ala Ala Phe Leu Gln Thr Met 
    530                 535                 540                 


Glu Gln Leu Asn Ile Glu Ala Glu Leu Gly Pro Glu Tyr Ala Met Phe 
545                 550                 555                 560 


Thr Arg Ser Arg Ala Val Ala Glu Gln Leu Arg Val Ile Asn Ser Phe 
                565                 570                 575     


Ala Leu Met Lys Lys Pro Gln Val Asn Ala Lys Gln Gln Leu Tyr Arg 
            580                 585                 590         


Ala Ala Val Thr Leu Leu Gly Thr Glu Asp Pro Asp Gly Val Thr Asp 
        595                 600                 605             


Glu Met Leu Cys Ile Asp Pro Val Thr Gly Lys Met Leu Pro Pro Asn 
    610                 615                 620                 


Gln Arg His His Gly Asp Thr Gly Leu Arg Asn Phe Ile Ala Asn Asn 
625                 630                 635                 640 


Val Val Glu Ser Arg Arg Phe Gln Tyr Leu Ile Arg Tyr Ser Asp Pro 
                645                 650                 655     


Ala Gln Leu His Gln Leu Ala Ser Asn Lys Lys Leu Val Arg Phe Val 
            660                 665                 670         


Leu Ser Ser Ile Pro Asp Thr Gln Ile Asn Arg Tyr Tyr Glu Thr Cys 
        675                 680                 685             


Gly Gln Thr Arg Leu Ala Gly Arg Ala Ala Lys Val Glu Phe Leu Thr 
    690                 695                 700                 


Asp Met Ile Ala Ala Ile Arg Phe Asp Gln Phe Arg Asp Val Asn Gln 
705                 710                 715                 720 


Lys Glu Arg Gly Ala Asn Thr Gln Lys Glu Arg Tyr Lys Ala Met Leu 
                725                 730                 735     


Gly Leu Tyr Gln Thr Val Leu Tyr Leu Ala Val Lys Asn Leu Val Asn 
            740                 745                 750         


Ile Asn Ala Arg Tyr Val Met Ala Phe His Cys Val Glu Arg Asp Met 
        755                 760                 765             


Phe Leu Tyr Asp Gly Glu Leu Thr Asp Pro Lys Gly Glu Ser Val Ser 
    770                 775                 780                 


Ala Phe Leu Ala Val Asn Gly Lys Lys Gly Val Gln Pro Gln Tyr Leu 
785                 790                 795                 800 


Leu Leu Thr Gln Leu Phe Ile Arg Arg Asp Tyr Leu Lys Arg Ser Ala 
                805                 810                 815     


Cys Glu Gln Ile Gln His Asn Met Glu Asn Ile Ser Asp Arg Leu Leu 
            820                 825                 830         


Arg Glu Tyr Arg Asn Ala Val Ala His Leu Asn Val Ile Ala His Leu 
        835                 840                 845             


Ala Asp Tyr Ser Ala Asp Met Arg Glu Ile Thr Ser Tyr Tyr Gly Leu 
    850                 855                 860                 


Tyr His Tyr Leu Met Gln Arg His Leu Phe Lys Arg His Ala Trp Gln 
865                 870                 875                 880 


Ile Arg Gln Pro Glu Arg Pro Thr Glu Glu Glu Gln Lys Leu Ile Glu 
                885                 890                 895     


Gln Glu Gln Lys Gln Leu Ala Trp Glu Lys Ala Leu Phe Asp Lys Thr 
            900                 905                 910         


Leu Gln Tyr His Ser Tyr Asn Lys Asp Leu Val Lys Ala Leu Asn Ala 
        915                 920                 925             


Pro Phe Gly Tyr Asn Leu Ala Arg Tyr Lys Asn Leu Ser Ile Glu Pro 
    930                 935                 940                 


Leu Phe Ser Lys Glu Ala Ala Pro Ala Ala Glu Ile Lys Ala Thr His 
945                 950                 955                 960 


Ala 
    


<210>  180
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Direct repeat

<400>  180
actatagccc tgccggaaat gacagggttc tacaac                                 36


<210>  181
<211>  963
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession):  contig emb|OCVV012889144.1|

<400>  181

Met Ser Lys Asn Lys Glu Ser Tyr Ala Lys Gly Met Gly Leu Lys Ser 
1               5                   10                  15      


Ala Leu Val Ser Gly Ser Lys Val Tyr Met Thr Ser Phe Glu Gly Gly 
            20                  25                  30          


Asn Asp Ala Lys Leu Glu Lys Val Val Glu Asn Ser Glu Ile Val Ser 
        35                  40                  45              


Leu Ala Glu Lys Glu Ser Phe Ser Ala Glu Ile Phe Lys Lys Asn Ile 
    50                  55                  60                  


Gly Cys Lys Ile Glu Asn Lys Lys Phe Lys His Pro Lys Arg Tyr Asp 
65                  70                  75                  80  


Val Ile Ala Asp Asn Pro Leu Tyr Lys Gly Ser Val Arg Gln Asp Met 
                85                  90                  95      


Leu Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Asn Ser Ala Asp 
            100                 105                 110         


Gly Thr Asp Asn Val Cys Ile Gln Val Ile His Asn Ile Leu Asp Ile 
        115                 120                 125             


Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Val Tyr Ser Phe Asp 
    130                 135                 140                 


Asn Ile Ala Gly Phe Gly Glu Asp Ile Ile Gly Met Gly Gly Phe Lys 
145                 150                 155                 160 


Pro Ile Tyr Thr Tyr Lys Gln Phe Lys Glu Pro Asp Lys Tyr Asn Lys 
                165                 170                 175     


Lys Phe Asp Asp Ile Leu Asn Asn Ser Arg Leu Gly Tyr Tyr Gly Lys 
            180                 185                 190         


Ala Phe Phe Glu Lys Asn Asp Leu Lys His Asn Pro Asn Lys Lys Lys 
        195                 200                 205             


Arg Asp Lys Asn Pro Tyr Ile Leu Lys Tyr Asp Asn Glu Cys Tyr Tyr 
    210                 215                 220                 


Ile Ile Ala Leu Leu Ser Gly Leu Arg His Trp Asn Ile His Ser His 
225                 230                 235                 240 


Ala Lys Asp Asp Leu Val Ser Tyr Arg Trp Leu Tyr Asn Leu Asp Ser 
                245                 250                 255     


Ile Leu Asn Arg Glu Tyr Ile Ser Thr Leu Asn Tyr Leu Tyr Asp Asp 
            260                 265                 270         


Ile Ala Asp Glu Leu Thr Glu Ser Phe Ser Lys Asn Ser Ser Ala Asn 
        275                 280                 285             


Val Asn Tyr Ile Ala Glu Thr Leu Asn Ile Asp Pro Ser Glu Phe Ala 
    290                 295                 300                 


Gln Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu Gln Lys Asn Met Gly 
305                 310                 315                 320 


Phe Asn Val Ser Lys Leu Arg Glu Ile Met Leu Asp Arg Lys Glu Leu 
                325                 330                 335     


Ser Asp Ile Arg Asp Asn His Arg Val Phe Asp Ser Ile Arg Ser Lys 
            340                 345                 350         


Leu Tyr Thr Met Met Asp Phe Val Ile Tyr Arg Tyr Tyr Ile Glu Glu 
        355                 360                 365             


Ala Ala Lys Thr Glu Ala Glu Asn Arg Asn Leu Pro Glu Asn Glu Lys 
    370                 375                 380                 


Lys Ile Ser Glu Lys Asp Phe Phe Val Ile Asn Leu Arg Gly Ser Phe 
385                 390                 395                 400 


Asp Glu Asn Gln Lys Glu Lys Leu Tyr Ile Glu Glu Ala Lys Arg Leu 
                405                 410                 415     


Trp Glu Lys Leu Lys Asp Ile Met Leu Lys Ile Lys Glu Phe Arg Gly 
            420                 425                 430         


Glu Lys Val Lys Glu Tyr Lys Lys Glu Val Pro Arg Ile Glu Arg Ile 
        435                 440                 445             


Leu Pro Gln Gly Lys Asp Ile Ser Ala Phe Ser Lys Leu Met Tyr Met 
    450                 455                 460                 


Leu Ser Met Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Phe Thr Thr 
465                 470                 475                 480 


Leu Ile Asn Lys Phe Asp Asn Ile Gln Cys Phe Leu Lys Ile Met Pro 
                485                 490                 495     


Leu Ile Gly Val Asn Val Lys Phe Thr Glu Asp Tyr Ala Phe Phe Asn 
            500                 505                 510         


Lys Ser Glu Lys Ile Ala Asp Glu Leu Arg Leu Ile Lys Ser Phe Ala 
        515                 520                 525             


Arg Met Gly Glu Pro Val Ala Asn Thr Lys Arg Val Met Met Ile Asp 
    530                 535                 540                 


Ala Val Lys Ile Leu Gly Thr Asp Leu Ser Asp Asp Glu Leu Val Asn 
545                 550                 555                 560 


Met Ala Asp Ser Phe Phe Asn Asp Ser Glu Gly Asn Leu Leu Lys Lys 
                565                 570                 575     


Gly Lys His Gly Met Arg Asn Phe Ile Ile Asn Asn Val Ile Glu Asn 
            580                 585                 590         


Lys Arg Phe His Tyr Leu Ile Arg Tyr Gly Asp Pro Ala His Leu His 
        595                 600                 605             


Glu Ile Ala Lys Asn Glu Ala Val Val Arg Phe Val Leu Gly Arg Ile 
    610                 615                 620                 


Ala Asp Ile Gln Lys Lys Gln Gly Lys Asp Gly Lys Asn Gln Ile Asp 
625                 630                 635                 640 


Arg Tyr Tyr Glu Ile Cys Val Gly Lys Asp Arg Gly Lys Thr Val Ser 
                645                 650                 655     


Gln Lys Leu Asp Glu Leu Thr Lys Ile Ile Val Asn Met Asn Tyr Asp 
            660                 665                 670         


Gln Phe Glu Gln Lys Lys Glu Ile Ile Glu Asn Thr Arg Thr Lys Thr 
        675                 680                 685             


Lys Tyr Met Arg Tyr Asp Glu Glu Gln Lys Leu Arg Lys Asp Asn Ala 
    690                 695                 700                 


Glu Arg Glu Lys Phe Lys Lys Ile Ile Ser Leu Tyr Leu Thr Val Leu 
705                 710                 715                 720 


Tyr Tyr Val Val Lys Asn Ile Val Asn Ile Asn Ser Arg Tyr Val Ile 
                725                 730                 735     


Gly Phe His Cys Leu Glu Arg Asp Ala Gln Leu Tyr Ser Glu Lys Tyr 
            740                 745                 750         


Asn Lys Glu Ile Asp Lys Lys Ile Ser Ser Leu Thr Lys Phe Cys Leu 
        755                 760                 765             


Gly Glu Ser Asp Glu Lys Lys Leu Lys Ala Leu Ala Lys Lys Ser Leu 
    770                 775                 780                 


Glu Glu Leu Lys Thr Thr Asn Ser Lys Leu Tyr Glu Asn Tyr Ile Lys 
785                 790                 795                 800 


Tyr Ser Asp Glu Arg Lys Ala Glu Glu Ala Lys Arg Gln Ile Asn Arg 
                805                 810                 815     


Glu Arg Ala Lys Thr Ala Met Asn Ala His Leu Arg Asn Thr Lys Trp 
            820                 825                 830         


Asn Asp Ile Met Tyr Gly Gln Leu Lys Asp Leu Ala Asp Ser Lys Ser 
        835                 840                 845             


Arg Ile Cys Ser Glu Phe Arg Asn Lys Ala Ala His Leu Glu Val Ala 
    850                 855                 860                 


Arg Tyr Ala His Met Tyr Ile Asn Asp Ile Ser Glu Val Lys Ser Tyr 
865                 870                 875                 880 


Phe Arg Leu Tyr His Tyr Ile Met Gln Arg Arg Ile Ile Asp Val Ile 
                885                 890                 895     


Glu Asn Asn Pro Lys Ala Lys Tyr Glu Gly Lys Val Lys Val Tyr Phe 
            900                 905                 910         


Glu Asp Val Lys Lys Asn Lys Lys Tyr Asn Lys Asn Leu Leu Lys Leu 
        915                 920                 925             


Met Cys Val Pro Phe Gly Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser 
    930                 935                 940                 


Ile Glu Gln Met Phe Asp Met Asn Glu Thr Asp Asn Ser Asp Lys Lys 
945                 950                 955                 960 


Lys Glu Lys 
            


<210>  182
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Direct repeat

<400>  182
catatacaac cccgtaaagt tacggggttc tgaaac                                 36


<210>  183
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession):  contig OCTW011587266.1

<400>  183

Met Lys Gln Asn Asp Arg Glu Asn Asn Asn Lys Ile Lys Lys Ser Ala 
1               5                   10                  15      


Ala Lys Ala Val Gly Val Lys Ser Leu Ala Arg Leu Ser Asp Gly Ser 
            20                  25                  30          


Thr Val Val Ser Ser Phe Gly Lys Gly Ala Ala Ala Glu Leu Glu Ser 
        35                  40                  45              


Leu Ile Thr Gly Gly Glu Ile Arg Lys Leu Ser Asp Lys Ala Ile Leu 
    50                  55                  60                  


Glu Ile Thr Asp Asp Thr Gln Asn Lys Asn Ala Tyr Asn Val Lys Ser 
65                  70                  75                  80  


Ser Arg Ile Pro Asn Leu Thr Ala Arg Thr Asp Lys Leu Ser Asp Lys 
                85                  90                  95      


Ser Gly Met Asp Asp Leu Gly Phe Lys Arg Glu Leu Glu Leu Glu Val 
            100                 105                 110         


Phe Gly Gln Cys Phe Asp Asp Ser Ile His Ile Gln Ile Ala His Ala 
        115                 120                 125             


Val Phe Asp Ile Gln Lys Ser Leu Ala Ala Val Ile Pro Asn Val Leu 
    130                 135                 140                 


Tyr Thr Leu Asn Asn Leu Asp Arg Ser Tyr Ser Thr Asp Asn Thr Ser 
145                 150                 155                 160 


Asp Lys Lys Asp Ile Ile Gly Asn Thr Leu Asn Tyr Gln His Ser Tyr 
                165                 170                 175     


Glu Ser Phe Asn Val Glu Lys Arg Gly Glu Phe Thr Glu Tyr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Asp Arg Phe Ser Tyr Phe Pro Asp Ile Leu Cys Val Leu 
        195                 200                 205             


Glu Lys Val Asn Gly Lys Asp Arg Tyr Gln Pro Lys Ser Glu Lys Asp 
    210                 215                 220                 


Ala Phe Asn Val Leu Ser Ser Val Asn Met Leu Arg Asn Ser Leu Phe 
225                 230                 235                 240 


His Phe Ala Pro Lys Ser Asn Asp Gly Lys Ala Arg Ile Ala Val Phe 
                245                 250                 255     


Lys Asn Gln Phe Asp Ser Asp Phe Ser His Ile Thr Ser Thr Val Asn 
            260                 265                 270         


Lys Ile Tyr Ser Ala Lys Ile Ala Gly Val Asn Glu Asn Phe Leu Asn 
        275                 280                 285             


Asn Glu Gly Asn Asn Leu Tyr Ile Ile Leu Lys Ala Thr Asn Trp Asp 
    290                 295                 300                 


Ile Lys Lys Ile Val Pro Gln Leu Tyr Arg Phe Ser Val Leu Lys Ser 
305                 310                 315                 320 


Asp Lys Asn Met Gly Phe Asn Met Arg Lys Leu Arg Glu Phe Ala Val 
                325                 330                 335     


Glu Ser Lys Asn Ile Asp Leu Ser Arg Leu Asn Asp Lys Phe Leu Thr 
            340                 345                 350         


Asn Asn Arg Lys Lys Leu Tyr Lys Val Ile Asp Phe Ile Ile Tyr Tyr 
        355                 360                 365             


His Leu Asn Lys Val Leu Lys Asp Ser Phe Val Asp Asp Phe Val Ala 
    370                 375                 380                 


Ala Leu Arg Ala Ser Gln Ser Glu Glu Glu Lys Glu Lys Leu Tyr Ala 
385                 390                 395                 400 


Gln Tyr Ser Glu Arg Leu Phe Ala Asp Glu Gly Leu Lys Ser Ala Ile 
                405                 410                 415     


Lys Lys Ala Val Asp Met Ile Ser Asp Thr Lys Ser Asn Ile Phe Lys 
            420                 425                 430         


Met Lys Thr Pro Leu Asp Lys Ala Leu Ile Glu Asn Ile Lys Val Asn 
        435                 440                 445             


Ser Asp Ala Ser Asp Phe Cys Lys Leu Ile Tyr Val Phe Thr Arg Phe 
    450                 455                 460                 


Leu Asp Gly Lys Glu Ile Asn Ile Leu Leu Asn Ser Leu Ile Lys Lys 
465                 470                 475                 480 


Phe Gln Asp Ile His Ser Phe Asn Thr Thr Val Lys Lys Leu Ser Glu 
                485                 490                 495     


Asn Asn Leu Ile Ile Asn Ala Asp Tyr Val Asp Asp Tyr Ser Leu Phe 
            500                 505                 510         


Glu Gln Ser Gly Thr Val Ala Arg Glu Leu Met Leu Ile Lys Ser Ile 
        515                 520                 525             


Ser Lys Met Asp Phe Gly Leu Asp Asn Ile Asn Leu Ser Phe Met Tyr 
    530                 535                 540                 


Asp Asp Ala Leu Arg Thr Leu Gly Val Ser Asp Glu Asn Leu Pro Glu 
545                 550                 555                 560 


Val Lys Arg Glu Tyr Phe Gly Lys Thr Lys Asn Leu Ser Ala Tyr Ile 
                565                 570                 575     


Arg Asn Asn Val Leu Glu Asn Arg Arg Phe Lys Tyr Val Ile Lys Tyr 
            580                 585                 590         


Ile His Pro Ser Asp Val Gln Lys Ile Ala Cys Asn Lys Ala Ile Ala 
        595                 600                 605             


Gly Phe Val Leu Asn Arg Met Pro Asp Thr Gln Ile Lys Arg Tyr Tyr 
    610                 615                 620                 


Asp Ser Leu Ile Asn Lys Gly Ala Thr Asp Ile Gln Ala Gln Ala Lys 
625                 630                 635                 640 


Ala Leu Leu Asp Cys Ile Thr Gly Ile Ser Phe Asp Ala Ile Lys Asp 
                645                 650                 655     


Asp Lys His Leu His Lys Ser Lys Glu Lys Ser Pro Gln Arg Ser Ala 
            660                 665                 670         


Asp Arg Glu Arg Lys Lys Ala Met Leu Thr Leu Tyr Tyr Thr Ile Val 
        675                 680                 685             


Tyr Ile Phe Val Lys Gln Met Leu His Ile Asn Ser Leu Tyr Thr Ile 
    690                 695                 700                 


Gly Phe Phe Tyr Leu Glu Arg Asp Gln Arg Phe Ile Tyr Ser Arg Ala 
705                 710                 715                 720 


Lys Lys Glu Asn Lys Asn Pro Ser Lys Asn Ser Tyr Leu Asn Asp Phe 
                725                 730                 735     


Arg Ser Val Thr Ala Tyr Phe Ile Pro Ser Glu Ile Met Lys Arg Ile 
            740                 745                 750         


Glu Lys Asn Glu Asn Lys Gly Phe Leu Glu Asp Phe Glu Ala Leu Trp 
        755                 760                 765             


Asn Ser Cys Gly Lys Thr Ser Arg Leu Arg Lys Glu Asp Val Leu Leu 
    770                 775                 780                 


Tyr Ala Arg Tyr Ile Ser Pro Asp His Ala Leu Lys Asn Tyr Lys Met 
785                 790                 795                 800 


Ile Leu Asn Ser Tyr Arg Asn Lys Ile Ala His Ile Asn Val Ile Met 
                805                 810                 815     


Ser Ala Gly Lys Tyr Thr Gly Gly Ile Lys Arg Met Asp Ser Tyr Phe 
            820                 825                 830         


Ser Val Phe Gln His Leu Val Gln Cys Asp Ile Leu Ser Asn Pro Asn 
        835                 840                 845             


Asn Lys Gly Lys Cys Phe Glu Ser Glu Ser Leu Lys Pro Leu Leu Leu 
    850                 855                 860                 


Asp Met Lys Phe Asp Gly Thr Asp Glu Lys Leu Tyr Ser Lys Arg Leu 
865                 870                 875                 880 


Thr Arg Ala Leu Asn Ile Pro Phe Gly Tyr Asn Val Pro Arg Tyr Lys 
                885                 890                 895     


Asn Leu Thr Phe Glu Lys Ile Tyr Leu Lys Ser Ser Ile Asn Glu 
            900                 905                 910     


<210>  184
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Direct repeat

<400>  184
cttatacaac acccattttc acagtgggtc tataac                                 36


<210>  185
<211>  904
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession):  contig   emb|OGNF01009141.1

<400>  185

Met Ala Asp Ile Asp Lys Lys Lys Ser Ser Ala Lys Ala Ala Gly Leu 
1               5                   10                  15      


Lys Ser Thr Phe Val Leu Glu Asn Asn Lys Leu Leu Met Thr Ser Phe 
            20                  25                  30          


Gly Asn Gly Asn Lys Ala Val Ile Glu Lys Ile Ile Asp Glu Lys Val 
        35                  40                  45              


Asp Ser Ile Asn Glu Pro Glu Val Phe Ser Val Thr Pro Cys Asp Lys 
    50                  55                  60                  


Lys Phe Glu Leu Gln Pro Ala Lys Arg Gly Leu Ala Ala Asp Ser Leu 
65                  70                  75                  80  


Val Asp Asn Pro Leu Lys Ser Lys Lys Thr Ala Gly Asp Asp Ala Ile 
                85                  90                  95      


His Ser Arg Lys Phe Leu Glu Arg Gln Phe Phe Asp Gly Asn Thr Phe 
            100                 105                 110         


Asn Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu 
        115                 120                 125             


Lys Ile Leu Ser Val His Val Asn Asp Ile Val Tyr Ser Val Asn Asn 
    130                 135                 140                 


Ile Leu Ser Arg Gly Glu Gly Met Glu Tyr Asn Asp Tyr Ile Gly Thr 
145                 150                 155                 160 


Leu Asn Leu Lys Ser Phe Glu Thr Tyr Lys Asn Asn Leu Val Asn Lys 
                165                 170                 175     


Lys Lys Phe Asp Leu Asp Arg Val Lys Lys Ile Pro Gln Leu Ala Tyr 
            180                 185                 190         


Phe Gly Ser Ala Phe Tyr Asn Thr Pro Glu Asp Thr Ser Ala Lys Ile 
        195                 200                 205             


Thr Lys Thr Lys Ile Lys Ser Asn Glu Glu Ile Tyr Tyr Thr Phe Met 
    210                 215                 220                 


Leu Leu Ser Thr Ala Arg Asn Phe Ser Ala His Tyr Leu Asp Arg Asn 
225                 230                 235                 240 


Arg Ala Lys Ser Ser Asp Ala Glu Asp Phe Asp Gly Thr Ser Val Ile 
                245                 250                 255     


Met Tyr Asn Leu Asp Asn Glu Glu Leu Tyr Lys Lys Leu Tyr Asn Lys 
            260                 265                 270         


Lys Val His Met Ala Leu Thr Gly Met Lys Lys Val Leu Asp Ala Asn 
        275                 280                 285             


Phe Asn Lys Lys Val Glu His Leu Asn Asn Ser Phe Ile Lys Asn Ser 
    290                 295                 300                 


Ala Lys Asp Phe Val Ile Leu Cys Glu Val Leu Gly Ile Lys Ser Arg 
305                 310                 315                 320 


Asp Glu Lys Thr Lys Phe Val Lys Asp Tyr Tyr Asp Phe Val Val Arg 
                325                 330                 335     


Lys Asn Tyr Lys His Leu Gly Phe Ser Val Lys Glu Leu Arg Glu Leu 
            340                 345                 350         


Leu Phe Ala Asn His Asp Ser Asn Lys Tyr Ile Lys Glu Phe Asp Lys 
        355                 360                 365             


Ile Ser Asn Lys Lys Phe Asp Ser Val Arg Ser Arg Leu Asn Arg Leu 
    370                 375                 380                 


Ala Asp Tyr Ile Ile Tyr Asp Tyr Tyr Asn Lys Asn Asn Ala Lys Val 
385                 390                 395                 400 


Ser Asp Leu Val Lys Tyr Leu Arg Ala Ala Ala Asp Asp Glu Gln Lys 
                405                 410                 415     


Lys Lys Ile Tyr Leu Asn Glu Ser Ile Asn Leu Val Lys Ser Gly Ile 
            420                 425                 430         


Leu Glu Arg Ile Lys Lys Ile Leu Pro Lys Leu Asn Gly Lys Ile Ile 
        435                 440                 445             


Gly Asn Met Gln Pro Asp Ser Thr Ile Thr Ala Ser Met Leu His Asn 
    450                 455                 460                 


Thr Gly Lys Asp Trp His Pro Ile Ser Glu Asn Ala His Tyr Phe Thr 
465                 470                 475                 480 


Lys Trp Ile Tyr Thr Leu Thr Leu Phe Met Asp Gly Lys Glu Ile Asn 
                485                 490                 495     


Asp Leu Val Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Ala Ser Phe 
            500                 505                 510         


Ile Glu Val Leu Lys Ser Gln Ser Val Cys Thr His Phe Ser Glu Glu 
        515                 520                 525             


Arg Lys Met Phe Ile Asp Ser Ala Glu Ile Cys Ser Glu Leu Ser Ala 
    530                 535                 540                 


Met Asn Ser Phe Ala Arg Met Glu Ala Pro Gly Ala Ser Ser Lys Arg 
545                 550                 555                 560 


Ala Met Phe Val Glu Ala Ala Arg Ile Leu Gly Asp Asn Arg Ser Lys 
                565                 570                 575     


Glu Glu Leu Glu Glu Tyr Phe Asp Thr Leu Phe Asp Lys Ser Ala Ser 
            580                 585                 590         


Lys Lys Glu Lys Gly Phe Arg Asn Phe Ile Arg Asn Asn Val Val Asp 
        595                 600                 605             


Ser Asn Arg Phe Lys Tyr Leu Thr Arg Tyr Thr Asp Thr Ser Ser Val 
    610                 615                 620                 


Lys Ala Phe Ser Asn Asn Lys Ala Leu Val Lys Phe Ala Ile Lys Asp 
625                 630                 635                 640 


Ile Pro Gln Glu Gln Ile Leu Arg Tyr Tyr Asn Ser Cys Phe Gly Ala 
                645                 650                 655     


Ser Glu Arg Tyr Tyr Asn Asp Gly Met Ser Asp Lys Leu Val Glu Ala 
            660                 665                 670         


Ile Gly Lys Ile Asn Leu Met Gln Phe Asn Gly Val Ile Gln Gln Ala 
        675                 680                 685             


Asp Arg Asn Met Leu Pro Glu Glu Lys Lys Lys Ala Asn Ala Gln Lys 
    690                 695                 700                 


Glu Lys Tyr Lys Ser Ile Ile Arg Leu Tyr Leu Thr Val Cys Tyr Leu 
705                 710                 715                 720 


Phe Phe Lys Asn Leu Val Tyr Val Asn Ser Arg Tyr Tyr Ser Ala Phe 
                725                 730                 735     


Tyr Asn Leu Glu Lys Asp Arg Ser Leu Phe Glu Ile Asn Gly Glu Leu 
            740                 745                 750         


Lys Pro Thr Gly Lys Phe Asp Glu Gly His Tyr Thr Gly Leu Val Lys 
        755                 760                 765             


Leu Phe Ile Asp Asn Gly Trp Ile Asn Pro Arg Ala Ser Ala Tyr Leu 
    770                 775                 780                 


Thr Val Asn Leu Ala Asn Ser Asp Glu Thr Ala Ile Arg Thr Phe Arg 
785                 790                 795                 800 


Asn Thr Ala Glu His Leu Glu Ala Leu Arg Asn Ala Asp Lys Tyr Leu 
                805                 810                 815     


Asn Asp Leu Lys Gln Phe Asp Ser Tyr Phe Glu Ile Tyr His Tyr Ile 
            820                 825                 830         


Thr Gln Arg Asn Ile Lys Glu Lys Cys Glu Met Leu Lys Glu Gln Thr 
        835                 840                 845             


Val Lys Tyr Asn Asn Asp Leu Leu Lys Tyr His Gly Tyr Ser Lys Asp 
    850                 855                 860                 


Phe Val Lys Ala Leu Cys Val Pro Phe Gly Tyr Asn Leu Pro Arg Phe 
865                 870                 875                 880 


Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asn Asp Lys Arg Glu 
                885                 890                 895     


Lys Leu Lys Lys Gly Phe Glu Asp 
            900                 


<210>  186
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Direct repeat

<400>  186
gaactacagc cctccttaaa tggggggttc taaaac                                 36


<210>  187
<211>  933
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession):  contig emb|OIEN01002196.1|

<400>  187

Met Glu Arg Gln Lys Arg Lys Met Lys Ser Lys Ser Lys Met Ala Gly 
1               5                   10                  15      


Val Lys Ser Val Phe Val Ile Gly Asp Glu Leu Leu Met Thr Ser Phe 
            20                  25                  30          


Gly Asp Gly Asp Asp Ala Val Leu Glu Lys Asp Ile Asp Glu Asn Gly 
        35                  40                  45              


Val Val Asn Asp Cys Arg Asn Pro Ala Ala Tyr Asp Ala Val Tyr Gly 
    50                  55                  60                  


Thr Asp Ser Ile Arg Val Lys Lys Thr Asn Asn Asn Ile Arg Ala Lys 
65                  70                  75                  80  


Val Asn Asn Pro Leu Ala Lys Ser Asn Ile Arg Ser Glu Glu Ser Ala 
                85                  90                  95      


Leu Phe Arg Thr Arg Val Asn Glu Tyr Lys Arg Glu Gln Lys Asp Lys 
            100                 105                 110         


Tyr Glu Thr Leu Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile 
        115                 120                 125             


Gln Leu Ile Ser Lys Ile Leu Asp Ile Glu Lys Thr Phe Ser Val Val 
    130                 135                 140                 


Ile Gly Asn Ile Val Tyr Ala Ile Asn Asn Leu Ser Leu Glu Gln Ser 
145                 150                 155                 160 


Ile Asp Arg Pro Ile Asp Ile Phe Gly Asp Lys Asn Thr Gln Gly Ile 
                165                 170                 175     


Ser Leu Arg Glu Asp Asn Asp Tyr Leu Lys Thr Met Leu Pro Arg Cys 
            180                 185                 190         


Glu Tyr Leu Phe His Asn Ile Leu Asn Ser Asp Ser Asp Asn Asn Ser 
        195                 200                 205             


Lys Met Asn Tyr Asn Lys Val Asn Lys Gly Lys Glu Glu Lys Asp Asn 
    210                 215                 220                 


Arg Asn Asn Glu Asn Ile Glu Lys Leu Lys Lys Ala Leu Glu Val Ile 
225                 230                 235                 240 


Lys Ile Ile Arg Val Asp Ser Phe His Gly Val Asp Gly Ile Lys Gly 
                245                 250                 255     


Asp Gln Lys Phe Pro Arg Ser Lys Tyr Asn Leu Ala Val Asn Tyr Asn 
            260                 265                 270         


Glu Glu Ile Gln Lys Thr Ile Ser Glu Pro Phe Asn Arg Lys Val Glu 
        275                 280                 285             


Glu Val Gln Gln Asp Phe Tyr Arg Asn Ser Cys Val Asn Ile Asp Phe 
    290                 295                 300                 


Leu Lys Glu Ile Met Tyr Gly Ser Asn Tyr Thr Asp Arg Gly Ser Asp 
305                 310                 315                 320 


Ser Leu Glu Cys Ser Tyr Phe Asn Phe Ala Ile Leu Lys Gln Asn Lys 
                325                 330                 335     


Asn Met Gly Phe Ser Ile Thr Ser Ile Arg Glu Cys Leu Leu Asp Leu 
            340                 345                 350         


Tyr Glu Leu Asn Phe Glu Ser Met Gln Asn Leu Arg Pro Arg Ala Asn 
        355                 360                 365             


Ser Phe Cys Asp Phe Leu Ile Tyr Asp Tyr Tyr Cys Lys Asn Glu Ser 
    370                 375                 380                 


Glu Arg Ala Asn Leu Val Asp Cys Leu Arg Ser Ala Ala Ser Glu Glu 
385                 390                 395                 400 


Glu Lys Lys Asn Ile Tyr Phe Gln Thr Ala Glu Arg Val Lys Glu Lys 
                405                 410                 415     


Phe Arg Asn Ala Phe Asn Arg Ile Ser Arg Phe Asp Ala Ser Tyr Ile 
            420                 425                 430         


Lys Asn Ser Arg Glu Lys Asn Leu Ser Gly Gly Ser Ser Leu Pro Lys 
        435                 440                 445             


Tyr Ser Phe Ile Glu Gly Phe Thr Lys Arg Ser Lys Lys Ile Asn Asp 
    450                 455                 460                 


Asn Asp Glu Lys Asn Ala Asp Leu Phe Cys Asn Met Leu Tyr Tyr Leu 
465                 470                 475                 480 


Ala Gln Phe Leu Asp Gly Lys Glu Ile Asn Ile Phe Leu Thr Ser Ile 
                485                 490                 495     


His Asn Ile Phe Gln Asn Ile Asp Ser Phe Leu Lys Val Met Lys Glu 
            500                 505                 510         


Lys Gly Met Glu Cys Lys Phe Gln Lys Asp Phe Lys Met Phe Ser His 
        515                 520                 525             


Ala Gly His Val Ala Lys Lys Ile Glu Ile Val Ile Ser Leu Ala Lys 
    530                 535                 540                 


Met Lys Lys Thr Leu Asp Phe Tyr Asn Ala Gln Ala Leu Lys Asp Ala 
545                 550                 555                 560 


Val Thr Ile Leu Gly Val Ser Lys Lys His Gln Tyr Leu Asp Met Asn 
                565                 570                 575     


Ser Tyr Leu Asp Phe Tyr Met Phe Asp Asn Arg Ser Gly Ala Thr Gly 
            580                 585                 590         


Lys Asn Ala Gly Lys Asp His Asn Leu Arg Asn Phe Leu Val Ser Asn 
        595                 600                 605             


Val Ile Arg Ser Arg Lys Phe Asn Tyr Leu Ser Arg Tyr Ser Asn Leu 
    610                 615                 620                 


Ala Glu Val Lys Lys Leu Ala Gln Asn Pro Ser Leu Val Gln Phe Val 
625                 630                 635                 640 


Leu Ser Arg Ile Glu Pro Ser Leu Ile Cys Arg Tyr Tyr Glu Ser Ser 
                645                 650                 655     


Gln Gly Ile Ser Ser Glu Gly Ile Thr Ile Asp Glu Gln Ile Lys Lys 
            660                 665                 670         


Leu Thr Gly Ile Ile Val Asp Met Asn Ile Asp Ser Phe Glu Asn Ile 
        675                 680                 685             


Asn Asn Gly Glu Ile Gly Met Arg Tyr Ser Lys Ala Thr Pro Gln Ser 
    690                 695                 700                 


Ile Glu Arg Arg Asn Gln Met Arg Val Cys Val Gly Leu Tyr Leu Asn 
705                 710                 715                 720 


Val Leu Tyr Gln Ile Glu Lys Asn Leu Met Asn Val Asn Ala Arg Tyr 
                725                 730                 735     


Val Leu Ala Phe Ala Phe Ala Glu Arg Asp Ala Leu Met Leu Asn Phe 
            740                 745                 750         


Thr Leu Glu Glu Cys Lys Lys Asn Lys Lys Arg Ser Ser Gly Gly Phe 
        755                 760                 765             


Ser Phe Ile Glu Met Thr Gln Phe Phe Ile Asp Lys Lys Leu Phe Lys 
    770                 775                 780                 


Val Ala Thr Glu Ala Ile Lys Lys Asn Val Leu Lys Tyr Asn Gly Asn 
785                 790                 795                 800 


Pro Glu Ser Leu Asn His Ile Pro Gly Glu Tyr Ile Cys Lys Asn Met 
                805                 810                 815     


Glu Gly Tyr His Glu Asn Thr Val Arg Asn Phe Arg Asn Met Val Ala 
            820                 825                 830         


His Leu Thr Ala Val Ala Arg Val Pro Leu Tyr Ile Ser Glu Val Thr 
        835                 840                 845             


Gln Ile Asp Ser Tyr Tyr Ala Leu Tyr His Tyr Cys Met Gln Met Asn 
    850                 855                 860                 


Ile Leu Gln Gly Ile Glu Gln Ser Gly Lys Ile Leu Asp Asn Ile Lys 
865                 870                 875                 880 


Leu Lys Asn Ala Leu Glu Asn Ala Arg Val His Arg Thr Tyr Ser Lys 
                885                 890                 895     


Asp Ala Val Lys Tyr Leu Cys Leu Pro Phe Ala Tyr Asn Ile Ser Arg 
            900                 905                 910         


Tyr Lys Ala Leu Thr Ile Lys Asp Leu Phe Asp Trp Thr Glu Tyr Ser 
        915                 920                 925             


Cys Lys Lys Asp Glu 
    930             


<210>  188
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Direct repeat

<400>  188
gccccttgac cttacgaaat ggtaaggttc caaaac                                 36


<210>  189
<211>  1034
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Metagenomic hit (no protein accession):  contig e-k87_11092736

<400>  189

Met Lys Arg Gln Lys Thr Phe Ala Lys Arg Ile Gly Ile Lys Ser Thr 
1               5                   10                  15      


Val Ala Tyr Gly Gln Gly Lys Tyr Ala Ile Thr Thr Phe Gly Lys Gly 
            20                  25                  30          


Ser Lys Ala Glu Ile Ala Val Arg Ser Ala Asp Pro Pro Glu Glu Thr 
        35                  40                  45              


Leu Pro Thr Glu Ser Asp Ala Thr Leu Ser Ile His Ala Lys Phe Ala 
    50                  55                  60                  


Lys Ala Gly Arg Asp Gly Arg Glu Phe Lys Cys Gly Asp Val Asp Glu 
65                  70                  75                  80  


Thr Arg Ile His Thr Ser Arg Ser Glu Tyr Glu Ser Leu Ile Ser Asn 
                85                  90                  95      


Pro Ala Glu Ser Pro Arg Glu Asp Tyr Leu Gly Leu Lys Gly Thr Leu 
            100                 105                 110         


Glu Arg Lys Phe Phe Gly Asp Glu Tyr Pro Lys Asp Asn Leu Arg Ile 
        115                 120                 125             


Gln Ile Ile Tyr Ser Ile Leu Asp Ile Gln Lys Ile Leu Gly Leu Tyr 
    130                 135                 140                 


Val Glu Asp Ile Leu His Phe Val Asp Gly Leu Gln Asp Glu Pro Glu 
145                 150                 155                 160 


Asp Leu Val Gly Leu Gly Leu Gly Asp Glu Lys Met Gln Lys Leu Leu 
                165                 170                 175     


Ser Lys Ala Leu Pro Tyr Met Gly Phe Phe Gly Ser Thr Asp Val Phe 
            180                 185                 190         


Lys Val Thr Lys Lys Arg Glu Glu Arg Ala Ala Ala Asp Glu His Asn 
        195                 200                 205             


Ala Lys Val Phe Arg Ala Leu Gly Ala Ile Arg Gln Lys Leu Ala His 
    210                 215                 220                 


Phe Lys Trp Lys Glu Ser Leu Ala Ile Phe Gly Ala Asn Ala Asn Met 
225                 230                 235                 240 


Pro Ile Arg Phe Phe Gln Gly Ala Thr Gly Gly Arg Gln Leu Trp Asn 
                245                 250                 255     


Asp Val Ile Ala Pro Leu Trp Lys Lys Arg Ile Glu Arg Val Arg Lys 
            260                 265                 270         


Ser Phe Leu Ser Asn Ser Ala Lys Asn Leu Trp Val Leu Tyr Gln Val 
        275                 280                 285             


Phe Lys Asp Asp Thr Asp Glu Lys Lys Lys Ala Arg Ala Arg Gln Tyr 
    290                 295                 300                 


Tyr His Phe Ser Val Leu Lys Glu Gly Lys Asn Leu Gly Phe Asn Leu 
305                 310                 315                 320 


Thr Lys Thr Arg Glu Tyr Phe Leu Asp Lys Phe Phe Pro Ile Phe His 
                325                 330                 335     


Ser Ser Ala Pro Asp Val Lys Arg Lys Val Asp Thr Phe Arg Ser Lys 
            340                 345                 350         


Phe Tyr Ala Ile Leu Asp Phe Ile Ile Tyr Glu Ala Ser Val Ser Val 
        355                 360                 365             


Ala Asn Ser Gly Gln Met Gly Lys Val Ala Pro Trp Lys Gly Ala Ile 
    370                 375                 380                 


Asp Asn Ala Leu Val Lys Leu Arg Glu Ala Pro Asp Glu Glu Ala Lys 
385                 390                 395                 400 


Glu Lys Ile Tyr Asn Val Leu Ala Ala Ser Ile Arg Asn Asp Ser Leu 
                405                 410                 415     


Phe Leu Arg Leu Lys Ser Ala Cys Asp Lys Phe Gly Ala Glu Gln Asn 
            420                 425                 430         


Arg Pro Val Phe Pro Asn Glu Leu Arg Asn Asn Arg Asp Ile Arg Asn 
        435                 440                 445             


Val Arg Ser Glu Trp Leu Glu Ala Thr Gln Asp Val Asp Ala Ala Ala 
    450                 455                 460                 


Phe Val Gln Leu Ile Ala Phe Leu Cys Asn Phe Leu Glu Gly Lys Glu 
465                 470                 475                 480 


Ile Asn Glu Leu Val Thr Ala Leu Ile Lys Lys Phe Glu Gly Ile Gln 
                485                 490                 495     


Ala Leu Ile Asp Leu Leu Arg Asn Leu Glu Gly Val Asp Ser Ile Arg 
            500                 505                 510         


Phe Glu Asn Glu Phe Ala Leu Phe Asn Asp Asp Lys Gly Asn Met Ala 
        515                 520                 525             


Gly Arg Ile Ala Arg Gln Leu Arg Leu Leu Ala Ser Val Gly Lys Met 
    530                 535                 540                 


Lys Pro Asp Met Thr Asp Ala Lys Arg Val Leu Tyr Lys Ser Ala Leu 
545                 550                 555                 560 


Glu Ile Leu Gly Ala Pro Pro Asp Glu Val Ser Asp Glu Trp Leu Ala 
                565                 570                 575     


Glu Asn Ile Leu Leu Asp Lys Ser Asn Asn Asp Tyr Gln Lys Ala Lys 
            580                 585                 590         


Lys Thr Val Asn Pro Phe Arg Asn Tyr Ile Ala Lys Asn Val Ile Thr 
        595                 600                 605             


Ser Arg Ser Phe Tyr Tyr Leu Val Arg Tyr Ala Lys Pro Thr Ala Val 
    610                 615                 620                 


Arg Lys Leu Met Ser Asn Pro Lys Ile Val Arg Tyr Val Leu Lys Arg 
625                 630                 635                 640 


Leu Pro Glu Lys Gln Val Ala Ser Tyr Tyr Ser Ala Ile Trp Thr Gln 
                645                 650                 655     


Ser Glu Ser Asn Ser Asn Glu Met Val Lys Leu Ile Glu Met Ile Asp 
            660                 665                 670         


Arg Leu Thr Thr Glu Ile Ala Gly Phe Ser Phe Ala Val Leu Lys Asp 
        675                 680                 685             


Lys Lys Asp Ser Ile Val Ser Ala Ser Arg Glu Ser Arg Ala Val Asn 
    690                 695                 700                 


Leu Glu Val Glu Arg Leu Lys Lys Leu Thr Thr Leu Tyr Met Ser Ile 
705                 710                 715                 720 


Ala Tyr Ile Ala Val Lys Ser Leu Val Lys Val Asn Ala Arg Tyr Phe 
                725                 730                 735     


Ile Ala Tyr Ser Ala Leu Glu Arg Asp Leu Tyr Phe Phe Asn Glu Lys 
            740                 745                 750         


Tyr Gly Glu Glu Phe Arg Leu His Phe Ile Pro Tyr Glu Leu Asn Gly 
        755                 760                 765             


Lys Thr Cys Gln Phe Glu Tyr Leu Ala Ile Leu Lys Tyr Tyr Leu Ala 
    770                 775                 780                 


Arg Asp Glu Glu Thr Leu Lys Arg Lys Cys Glu Ile Cys Glu Glu Ile 
785                 790                 795                 800 


Lys Val Gly Cys Glu Lys His Lys Lys Asn Ala Asn Pro Pro Tyr Glu 
                805                 810                 815     


Tyr Asp Gln Glu Trp Ile Asp Lys Lys Lys Ala Leu Asn Ser Glu Arg 
            820                 825                 830         


Lys Ala Cys Glu Arg Arg Leu His Phe Ser Thr His Trp Ala Gln Tyr 
        835                 840                 845             


Ala Thr Lys Arg Asp Glu Asn Met Ala Lys His Pro Gln Lys Trp Tyr 
    850                 855                 860                 


Asp Ile Leu Ala Ser His Tyr Asp Glu Leu Leu Ala Leu Gln Ala Thr 
865                 870                 875                 880 


Gly Trp Leu Ala Thr Gln Ala Arg Asn Asp Ala Glu His Leu Asn Pro 
                885                 890                 895     


Val Asn Glu Phe Asp Val Tyr Ile Glu Asp Leu Arg Arg Tyr Pro Glu 
            900                 905                 910         


Gly Thr Pro Lys Asn Lys Asp Tyr His Ile Gly Ser Tyr Phe Glu Ile 
        915                 920                 925             


Tyr His Tyr Ile Arg Gln Arg Ala Tyr Leu Glu Glu Val Leu Ala Lys 
    930                 935                 940                 


Arg Lys Glu Tyr Arg Asp Ser Gly Ser Phe Thr Asp Glu Gln Leu Asp 
945                 950                 955                 960 


Lys Leu Gln Lys Ile Leu Asp Asp Ile Arg Ala Arg Gly Ser Tyr Asp 
                965                 970                 975     


Lys Asn Leu Leu Lys Leu Glu Tyr Leu Pro Phe Ala Tyr Asn Leu Pro 
            980                 985                 990         


Arg Tyr Lys Asn Leu Thr Thr Glu  Ala Leu Phe Asp Asp  Asp Ser Val 
        995                 1000                 1005             


Ser Gly  Lys Lys Arg Val Ala  Glu Trp Arg Glu Arg  Glu Lys Thr 
    1010                 1015                 1020             


Arg Glu  Ala Glu Arg Glu Gln  Arg Arg Gln Arg 
    1025                 1030                 


<210>  190
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Direct repeat 1

<400>  190
gtgagaagtc tccttatggg gagatgctac                                        30


<210>  191
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Direct repeat 2

<400>  191
gtagcatctc cccataagga gacttctcac                                        30


<210>  192
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Direct repeat 3

<400>  192
gctagggctt gtaggaattc cttgctatgg tacaat                                 36


<210>  193
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Direct repeat 4

<400>  193
attgtaccat agcaaggaat tcctacaagc cctagc                                 36


<210>  194
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Gut_metagenome_contig6893000291

<400>  194

Met Tyr Pro Phe Ile Asn Phe Ala Ile Phe Arg Tyr Tyr Asn Val Tyr 
1               5                   10                  15      


His Lys Glu Ala Asp Tyr Leu Val Asp Ser Leu Arg Ala Ser Met Asn 
            20                  25                  30          


Glu Val Glu Lys Asp Ala Val Tyr Arg Arg Glu Ala Val Arg Ile Trp 
        35                  40                  45              


Pro Arg Leu Lys Lys Leu Ile Leu Asn His Ile Leu Pro Glu Met Thr 
    50                  55                  60                  


Gly Ser Lys Ile Lys Glu Lys Asp Ala Lys Pro Asp Pro Glu Met Asp 
65                  70                  75                  80  


Ala Ser Met Ile Asp Ser Val Lys Ile Gly Thr Glu Ser Thr Leu Phe 
                85                  90                  95      


Thr Lys Ile Ile Phe Leu Thr Thr Leu Phe Leu Asn Gly Lys Glu Thr 
            100                 105                 110         


Asn Asp Leu Ile 
        115     


<210>  195
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cas13d direct repeat


<220>
<221>  misc_feature
<222>  (2)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  195

Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp 
            20                  25                  30  


<210>  196
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cas13d direct repeat


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  196

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Tyr Xaa Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  197
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cas13d direct repeat


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  197

Tyr Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  198
<211>  940
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ga0224415_10007274

<400>  198

Met Ile Glu Lys Lys Lys Ser Tyr Ala Lys Gly Met Gly Leu Lys Ser 
1               5                   10                  15      


Thr Ile Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Gly Asp Gly 
            20                  25                  30          


Ser Glu Ala Arg Leu Glu Lys Val Val Glu Asn Asp Ser Ile Lys Thr 
        35                  40                  45              


Leu His Glu Gly Glu Ala Phe Ser Ala Glu Met Thr Asp Asn Asn Ala 
    50                  55                  60                  


Gly Tyr Lys Ile Gly Asn Val Lys Phe Ser His Pro Asn Gly Tyr Asp 
65                  70                  75                  80  


Val Val Ala Asn Asn Pro Phe Tyr Thr Gly Pro Val Gln Gln Asp Met 
                85                  90                  95      


Leu Gly Leu Lys Glu Ile Leu Glu Arg Arg Tyr Phe Gly Ser Ser Thr 
            100                 105                 110         


Asp Gly Asn Asn Thr Ile Cys Ile Gln Ile Ile His Asn Ile Leu Asp 
        115                 120                 125             


Ile Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Val Tyr Ala Thr 
    130                 135                 140                 


Asn Asn Ile Ile Asp Pro Asp Asn Asp Val Ile Gly Gly Lys Lys Phe 
145                 150                 155                 160 


Thr Ser Ile Lys Thr Phe Ala Gln Phe Ser Ala Ser Asp Ser Ser Asn 
                165                 170                 175     


Asp Phe Glu Gln Phe Leu Lys Asn Pro Arg Leu Gly Tyr Leu Gly Lys 
            180                 185                 190         


Ala Phe Phe Tyr Lys Asp Gly Lys Arg Asn Asn Arg Gln Lys Asp Pro 
        195                 200                 205             


Ile Glu Cys Tyr His Leu Leu Ala Leu Leu Cys Gly Leu Arg Asn Trp 
    210                 215                 220                 


Val Val His Asn Asn Glu Glu Lys Asp Leu Ile Lys Tyr Thr Trp Leu 
225                 230                 235                 240 


Tyr Asn Leu Asp Lys Tyr Leu Asp Ala Glu Tyr Ile Thr Thr Leu Asn 
                245                 250                 255     


Tyr Met Tyr Asn Asp Ile Gly Asp Glu Leu Thr Asp Ser Phe Ser Lys 
            260                 265                 270         


Asn Ser Ala Ala Asn Ile Asn Tyr Ile Ala Glu Thr Leu Gly Ile Asp 
        275                 280                 285             


Pro Lys Thr Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu 
    290                 295                 300                 


Gln Lys Asn Leu Gly Phe Asn Leu Thr Lys Leu Arg Glu Val Met Leu 
305                 310                 315                 320 


Asp Arg Lys Asp Met Ser Glu Ile Arg Glu Asn His Asn Asp Phe Asp 
                325                 330                 335     


Ser Ile Arg Ala Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr Arg 
            340                 345                 350         


Tyr Tyr Ile Glu Glu Ala Ala Lys Val Asn Ala Ala Asn Lys Ser Leu 
        355                 360                 365             


Pro Asp Asn Glu Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile Ser 
    370                 375                 380                 


Leu Arg Gly Ser Phe Asn Glu Asp Gln Lys Asp Arg Leu Tyr Tyr Asp 
385                 390                 395                 400 


Glu Ala Gln Arg Leu Trp Ser Lys Val Gly Lys Leu Met Leu Lys Ile 
                405                 410                 415     


Lys Lys Phe Arg Gly Lys Asp Thr Arg Lys Tyr Lys Asn Met Gly Thr 
            420                 425                 430         


Pro Arg Ile Arg Arg Leu Ile Pro Glu Gly Arg Asp Ile Ser Thr Phe 
        435                 440                 445             


Ser Lys Leu Met Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu Ile 
    450                 455                 460                 


Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln Ser 
465                 470                 475                 480 


Phe Leu Lys Val Met Pro Leu Ile Gly Val Asn Ala Lys Phe Ala Glu 
                485                 490                 495     


Glu Tyr Ser Phe Phe Asn Asn Ser Glu Lys Ile Ala Asp Glu Leu Arg 
            500                 505                 510         


Leu Ile Lys Ser Phe Ala Arg Met Gly Glu Pro Val Ala Asp Ala Arg 
        515                 520                 525             


Arg Ala Met Tyr Ile Asp Ala Ile Arg Ile Leu Gly Thr Asp Leu Ser 
    530                 535                 540                 


Asp Asp Glu Leu Lys Ala Leu Ala Asp Ser Phe Ser Leu Asp Glu Asn 
545                 550                 555                 560 


Gly Asn Lys Leu Gly Lys Gly Lys His Gly Met Arg Asn Phe Ile Ile 
                565                 570                 575     


Asn Asn Val Ile Thr Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr Gly 
            580                 585                 590         


Asn Pro Val His Leu His Glu Ile Ala Lys Asn Glu Ala Val Val Lys 
        595                 600                 605             


Phe Val Leu Gly Arg Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln Asn 
    610                 615                 620                 


Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys Asp 
625                 630                 635                 640 


Ser Ser Lys Ser Val Ala Glu Lys Val Asn Ala Leu Thr Lys Ile Ile 
                645                 650                 655     


Thr Gly Met Asn Tyr Asp Gln Phe Asp Ser Arg Arg Asn Val Ile Glu 
            660                 665                 670         


Asn Thr Gly Ala Gly Asn Ala Glu Arg Glu Lys Tyr Lys Lys Ile Ile 
        675                 680                 685             


Ser Leu Tyr Leu Thr Val Ile Tyr His Ile Leu Lys Asn Ile Val Asn 
    690                 695                 700                 


Ile Asn Ser Arg Tyr Val Ile Gly Phe His Cys Val Glu Arg Asp Ala 
705                 710                 715                 720 


Gln Leu Tyr Lys Glu Lys Gly Tyr Asp Ile Asn Leu Lys Lys Leu Lys 
                725                 730                 735     


Asp Lys Gly Phe Thr Ser Val Thr Lys Leu Cys Ala Gly Ile Asp Glu 
            740                 745                 750         


Glu Cys Lys Asp Val Glu Lys Glu Met Thr Glu Arg Ala Lys Ala Ser 
        755                 760                 765             


Phe Ala Ala Leu Glu Thr Ala Asn Pro Lys Leu Tyr Ala Thr Tyr Ile 
    770                 775                 780                 


Asn Tyr Ser Asp Glu Glu Lys Asn Ala Glu Leu Arg Lys Gln Ile Asn 
785                 790                 795                 800 


Arg Glu Lys Ala Lys Thr Ala Leu Asn Ala His Leu Arg Asn Thr Lys 
                805                 810                 815     


Trp Asn Val Ile Ile Arg Glu Asp Leu Leu Arg Arg Asp Asn Lys Ala 
            820                 825                 830         


Cys Lys Ile Phe Arg Asn Lys Val Ala His Leu Glu Ala Ile Arg Tyr 
        835                 840                 845             


Ala His Leu Tyr Ile Asn Asp Ile Ala Glu Val Asn Ser Tyr Phe Gln 
    850                 855                 860                 


Phe Tyr His Tyr Ile Met Gln Arg Arg Ile Met Ala Glu Arg Tyr Asp 
865                 870                 875                 880 


Lys Ser Ser Gly Lys Val Arg Glu Tyr Phe Asp Ala Val Asn Asn Glu 
                885                 890                 895     


Lys Lys Tyr Asn Asp Arg Leu Leu Lys Leu Leu Cys Val Pro Phe Gly 
            900                 905                 910         


Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Ala Leu Phe Asp 
        915                 920                 925             


Met Asn Glu Ala Val Lys Phe Asp Lys Glu Lys Lys 
    930                 935                 940 


<210>  199
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  199
caagtaaacc cctaccaagt ggtcggggtt tgaaac                                 36


<210>  200
<211>  1057
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EMG_10003641

<400>  200

Met Glu Glu Thr Lys Val Thr Lys Glu Thr Thr Ile Glu Lys Gln Ser 
1               5                   10                  15      


Thr Lys Arg His Lys Gln Lys Ser Lys Lys Thr Ala Thr Lys Met Ser 
            20                  25                  30          


Gly Leu Lys Ser Ala Leu Val Ile Asn Asn His Glu Met Leu Leu Thr 
        35                  40                  45              


Ser Phe Gly Lys Gly Asn Asn Ala Ile Ala Glu Lys Arg Tyr Ile Leu 
    50                  55                  60                  


Asp Gly Asp Ile Glu Thr Ile Asn Asn Lys Asn Lys Lys Phe Asp Ala 
65                  70                  75                  80  


Asn Asn Asp Ser Lys Val Val Val Ile Lys Gly Ile Ser Asn Pro Asn 
                85                  90                  95      


Gly Gln Leu Thr Asn Pro Leu Phe Asp Gln Ser Pro Thr Ala Ile Gln 
            100                 105                 110         


Pro Asn Arg Thr Ser Gly Asn Asp Met Ile Gly Ile Arg Arg Met Leu 
        115                 120                 125             


Glu Arg Lys Tyr Phe Val His Asn Glu Glu Asn Lys Glu Phe Gln Asp 
    130                 135                 140                 


Asn Ile Arg Ile Gln Ile Ala Tyr Cys Ile Leu Asp Ile Glu Lys Ile 
145                 150                 155                 160 


Leu Met Pro His Ile Asn Asn Ile Cys Phe Glu Ile Asn Asn Met Leu 
                165                 170                 175     


Arg Leu Glu Gly Tyr Gln Glu Asp Ser Phe Met Gly Ser Phe Asn Leu 
            180                 185                 190         


Tyr Lys Pro Tyr Asp Ala Phe Ile Ala Thr Thr Asp Asp Lys Glu Ser 
        195                 200                 205             


Ser Arg Arg Asp Asn Phe Ala Lys Leu Met Thr Ser Lys Gln Val Arg 
    210                 215                 220                 


Tyr Leu Gly Asn Ala Leu Tyr Ser Asp Ser Leu Ser Asn Leu Thr Lys 
225                 230                 235                 240 


Asp Glu Ile Leu Asp Gly Lys Arg Ser Lys Glu Leu Lys Lys Tyr Tyr 
                245                 250                 255     


Gln Glu Leu Cys Leu Leu Gly Met Val Arg Gln Ser Met Ile His Ser 
            260                 265                 270         


Asn Gln Phe Asn Ser Ser Ile Tyr Thr Leu Asp Ser Ser Tyr Asp Ser 
        275                 280                 285             


Thr Met Asn Thr Ala Glu Leu Leu Gly Lys Gly Asp Asp Ser Ser Leu 
    290                 295                 300                 


Val Ala Leu Ala Thr Asp Ala Arg Val Glu Ala Arg Ala Ile Leu Asp 
305                 310                 315                 320 


Glu Ile Tyr Lys Lys Gly Val Asp Ser Ile Asn Asn Ser Phe Leu Ser 
                325                 330                 335     


Asn Ser Ile Asn Asp Leu Glu Asn Leu Phe Lys Ile Tyr Lys Cys Asp 
            340                 345                 350         


Ser Ser Glu Lys Lys Thr Glu Leu Ile Lys Gln Tyr Tyr Asp Phe Cys 
        355                 360                 365             


Ile Arg Lys Pro Gln Met Asn Met Gly Phe Ser Ile Thr Thr Ile Arg 
    370                 375                 380                 


Glu Gly Met Phe Thr Arg Cys Ser Glu Ala Asn Thr Leu Leu Leu Cys 
385                 390                 395                 400 


Asp Glu Gly Ser Thr Val Lys Leu Asn Val His Asp Thr Met Lys Ser 
                405                 410                 415     


Lys Phe Tyr Lys Asn Leu Asp Phe Met Ile Tyr Lys Tyr Tyr Lys Tyr 
            420                 425                 430         


Glu Asn Pro Glu Lys Gly Glu Lys Leu Ile Glu Asp Leu Arg Ser Lys 
        435                 440                 445             


Ile Lys Gly Lys Lys Lys Glu Asp Glu Asp Lys Lys Gln Arg Tyr Ala 
    450                 455                 460                 


Glu Glu Ser Ala Cys Ile Leu Lys Ala Lys Arg Asp Ile Ile Lys Lys 
465                 470                 475                 480 


Asp Leu Thr Glu Ala Ala Asn Lys Asp Leu Phe Ala Asp Leu Val Lys 
                485                 490                 495     


Ser Asn Lys Asn Glu Lys Gln Lys Phe Lys Asn Glu Tyr Glu Glu Leu 
            500                 505                 510         


Leu Lys Pro Phe Met Ile Pro Val Lys Val Asp Tyr Phe Ser Glu Leu 
        515                 520                 525             


Ile Tyr Leu Val Thr Arg Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu 
    530                 535                 540                 


Leu Thr Gln Leu Ile Asn Lys Phe Glu Asn Ile Ala Ala Phe Ile Arg 
545                 550                 555                 560 


Met Tyr Gln Asn Asp Gln Gly Lys Leu Glu Phe Thr Ala Asn Tyr Lys 
                565                 570                 575     


Met Phe Glu Ile Asp Pro Gln Lys Asp Ile Pro Lys Asp Gly Lys Arg 
            580                 585                 590         


Val Leu Ser Gly Ser Ala Lys Ile Ala Tyr Tyr Leu Arg Thr Ile Asn 
        595                 600                 605             


Tyr Ile Ala Arg Met Glu Ser Phe Glu Ile Lys Ser Asp Lys Thr Ala 
    610                 615                 620                 


Ile Asn Asp Ala Ile Ser Leu Leu Gly Tyr Asn Ser Asn Glu His Arg 
625                 630                 635                 640 


Asp Glu Phe Ile Thr Tyr Thr Met Ala Lys His Val Val Asp Lys Tyr 
                645                 650                 655     


Gln Asn Thr Asp Tyr Gln Lys Ile Val Lys Asp Phe Leu Ser Ala Asn 
            660                 665                 670         


Lys Thr Leu Asp Cys Lys Ser Lys Asn Met Gln Ala Phe Val Ser Glu 
        675                 680                 685             


Leu Lys Asn Ala His Leu Ser Glu Asn Tyr Glu Gln Arg Glu Lys Glu 
    690                 695                 700                 


Ile Tyr Glu Leu Ala Asp Thr Asn Leu Pro Ala Tyr Phe Ser Glu Glu 
705                 710                 715                 720 


Asp Lys Glu Lys Leu Ala Arg Tyr Ile Val His Ser Asp Gly Thr Tyr 
                725                 730                 735     


Lys Lys Phe Leu Lys Glu Ser Phe Tyr Ala Ile Glu Glu Leu Pro Asn 
            740                 745                 750         


Glu Gly Phe Arg Asn Phe Ile Ser Asn Asn Val Ile Asn Ser Arg Arg 
        755                 760                 765             


Phe Asn Tyr Ile Met Arg Phe Cys Asn Pro Glu Lys Ile Ala Asn Ile 
    770                 775                 780                 


Gly Lys Asn Lys Val Leu Ile Ser Phe Ala Leu Ser Ser Leu Ala Glu 
785                 790                 795                 800 


Lys Thr Asp Met Ile Ala Lys Tyr Tyr Arg Val Phe Cys Asp Arg Ile 
                805                 810                 815     


Asp Asp Gln Lys Thr Met Glu Asp Tyr Leu Val Asn Lys Leu Thr Lys 
            820                 825                 830         


Ile Ser Tyr Thr Glu Phe Leu Asn Val Asn Gln Lys Ala Asn Ala Glu 
        835                 840                 845             


Lys Asn Lys Glu Lys Asp Arg Ser Gln Lys Leu Ile Gly Leu Tyr Ile 
    850                 855                 860                 


Thr Leu Leu Tyr Glu Ile Val Lys Asn Leu Val Asn Ile Asn Ser Arg 
865                 870                 875                 880 


Tyr Asn Ile Ala Phe Gln Arg Cys Asp Asn Asp Ser Ile Met Ile Leu 
                885                 890                 895     


Gln Gly Gln Tyr Asp Glu Arg Ala Val Gln Glu Ser Lys Leu Thr Lys 
            900                 905                 910         


Lys Phe Ile Ser Asn Gln Lys Leu Asn Ser Tyr Ser Cys Arg Tyr Leu 
        915                 920                 925             


Thr His Asn Ile Ser Gln Leu Asp Arg Cys Asn Asp Phe Ile Arg Gln 
    930                 935                 940                 


Tyr Arg Asn Lys Val Ala His Leu Glu Val Val Ser Asn Ile Asp Glu 
945                 950                 955                 960 


Tyr Leu Ser Gly Ile Lys His Ile Glu Ser Tyr Tyr Ala Leu Tyr His 
                965                 970                 975     


Tyr Leu Met Gln Lys Cys Leu Leu Lys Asn Tyr Arg Ile Glu Asp His 
            980                 985                 990         


Ser Gln Asn Glu Tyr Lys Asn Leu  Asn Asp Phe Ser Ser  Lys Leu Asp 
        995                 1000                 1005             


Lys His  Gly Thr Tyr Val Lys  Asp Phe Val Lys Ala  Leu Asn Val 
    1010                 1015                 1020             


Pro Phe  Gly Tyr Asn Leu Pro  Arg Tyr Lys Asn Leu  Ser Ile Asp 
    1025                 1030                 1035             


Glu Leu  Phe Asp Arg Asn Lys  Leu Lys Thr Gly Gly  Thr Ile Glu 
    1040                 1045                 1050             


Met Lys  Gly Glu 
    1055         


<210>  201
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  201
gaactacacc cctgcagaaa tgctggggtc tgaaac                                 36


<210>  202
<211>  973
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ga0129306_1000735

<400>  202

Met Gln Lys Gln Arg Glu Gln Gln Thr Val Thr Asp Glu Ser Glu Arg 
1               5                   10                  15      


Lys Lys Lys Pro Leu Lys Ser Gly Ala Lys Ala Ala Gly Leu Lys Ser 
            20                  25                  30          


Val Phe Val Leu Ser Glu Gly Lys Glu Leu Leu Thr Ser Phe Gly Arg 
        35                  40                  45              


Gly Asn Glu Ala Val Pro Glu Lys Arg Val Thr Gly Gly Thr Ile Ala 
    50                  55                  60                  


Asn Ala Arg Thr Asp Asn Lys Glu Ala Phe Ser Ala Ala Leu Gln Asn 
65                  70                  75                  80  


Lys Arg Phe Glu Val Phe Gly Arg Thr Ala Gly Ser Ser Asp Asp Pro 
                85                  90                  95      


Leu Ala Val Ser Arg Ala Pro Gly Gln Asp Leu Ile Gly Ala Lys Thr 
            100                 105                 110         


Ala Leu Glu Glu Arg Tyr Phe Gly Arg Ala Phe Ala Asp Asn Ile His 
        115                 120                 125             


Met Gln Val Ile Tyr Ala Ile Gln Asp Ile Asn Lys Ile Leu Ala Val 
    130                 135                 140                 


His Ala Asn Asn Ile Val Tyr Thr Leu Asn Asn Leu Asp Arg Glu Ala 
145                 150                 155                 160 


Asp Pro Glu Thr Asp Asp Phe Ile Gly Ser Gly Tyr Leu Thr Leu Lys 
                165                 170                 175     


Asn Thr Phe Glu Thr Tyr Cys Asp Pro Ala Ala Leu Asn Glu Arg Glu 
            180                 185                 190         


Arg Glu Lys Val Thr Val Ser Lys Gln His Phe Asp Ala Phe Met Gln 
        195                 200                 205             


Asn Pro Arg Leu Ala Tyr Tyr Gly Asn Ala Phe Phe Arg Lys Leu Ser 
    210                 215                 220                 


Lys Ala Glu Arg Leu Ala Arg Gly Arg Glu Ile Phe Asp Lys Glu Ser 
225                 230                 235                 240 


Pro Glu Arg Arg Gln Glu Ile Leu Gly Ser Arg Gly Lys Asn Lys Ser 
                245                 250                 255     


Val Asp Asp Glu Ile Arg Ala Leu Ala Pro Glu Trp Val Lys Arg Glu 
            260                 265                 270         


Glu Arg Asp Val Tyr Ser Glu Leu Val Leu Met Ser Glu Leu Arg Gln 
        275                 280                 285             


Ser Cys Phe His Gly Gln Gln Lys Asn Ser Ala Arg Ile Phe Arg Leu 
    290                 295                 300                 


Asp Asn Asp Leu Gly Pro Gly Val Asp Gly Ala Arg Glu Leu Leu Asp 
305                 310                 315                 320 


Arg Leu Tyr Ala Glu Lys Ile Asn Asp Leu Arg Ser Phe Asp Lys Thr 
                325                 330                 335     


Ser Ala Ser Ser Asn Phe Arg Leu Leu Phe Asn Ala Tyr His Ala Asp 
            340                 345                 350         


Asn Glu Lys Lys Lys Glu Leu Ala Gln Glu Phe Tyr Arg Phe Ser Val 
        355                 360                 365             


Leu Lys Val Ser Lys Asn Thr Gly Phe Ser Ile Arg Thr Leu Arg Glu 
    370                 375                 380                 


Lys Ile Ile Glu Asp His Ala Ala Gln Tyr Arg Asp Lys Ile Tyr Asp 
385                 390                 395                 400 


Ser Met Arg Lys Lys Leu Phe Ser Thr Phe Asp Phe Phe Leu Trp Arg 
                405                 410                 415     


Phe Tyr Glu Glu Arg Glu Asp Glu Ala Glu Glu Leu Arg Ala Cys Leu 
            420                 425                 430         


Arg Ala Ala Arg Ser Asp Glu Glu Lys Glu Gln Ile Tyr Ala Glu Ala 
        435                 440                 445             


Ala Ala Ser Cys Trp Pro Ser Val Lys Pro Phe Val Glu Ser Val Ala 
    450                 455                 460                 


Ala Thr Leu Cys Asp Val Val Lys Gly Arg Thr Lys Leu Asn Lys Leu 
465                 470                 475                 480 


Lys Leu Ser Ala Asp Glu Ser Thr Leu Val Arg Asn Ala Ile Asp Gly 
                485                 490                 495     


Val Arg Ile Ser Pro Arg Ala Ser Tyr Phe Thr Lys Leu Ile Tyr Leu 
            500                 505                 510         


Met Thr Leu Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr 
        515                 520                 525             


Leu Ile His Ala Phe Glu Asn Ile Asp Ser Phe Leu Ser Val Leu Gly 
    530                 535                 540                 


Ser Glu Arg Leu Glu Arg Thr Phe Asp Ala Asn Tyr Arg Ile Phe Ala 
545                 550                 555                 560 


Asp Ser Gly Val Ile Ala Gln Glu Leu Arg Ala Val Asn Ser Phe Ala 
                565                 570                 575     


Arg Met Thr Thr Glu Pro Phe Asn Ser Lys Leu Val Met Phe Glu Asp 
            580                 585                 590         


Ala Ala Gln Leu Phe Gly Met Ser Gly Gly Leu Val Glu His Ala Glu 
        595                 600                 605             


Glu Leu Arg Glu Tyr Leu Asp Asn Lys Met Leu Asp Lys Thr Lys Leu 
    610                 615                 620                 


Arg Leu Leu Pro Asp Gly Lys Val Asp Thr Gly Phe Arg Asn Phe Ile 
625                 630                 635                 640 


Ile Ser Asn Val Thr Glu Ser Arg Arg Phe Arg Tyr Leu Val Arg Tyr 
                645                 650                 655     


Cys Glu Pro Arg Ala Val Arg Asp Tyr Met Ser Cys Arg Pro Leu Ile 
            660                 665                 670         


Arg Leu Thr Leu Arg Asp Met Pro Asp Thr Ile Leu Arg Arg Tyr Tyr 
        675                 680                 685             


Glu Gln Ser Val Gly Ala Ala Thr Val Asp Arg Glu Arg Ile Leu Asp 
    690                 695                 700                 


Thr Leu Ala Asp Lys Leu Leu Ser Leu Arg Phe Thr Asp Phe Glu Asn 
705                 710                 715                 720 


Val Asn Gln Arg Ala Asn Ala Glu Arg Asn Arg Glu Lys Gln Lys Met 
                725                 730                 735     


Met Gly Ile Ile Ser Leu Tyr Leu Asn Val Ala Tyr Gln Ile Val Lys 
            740                 745                 750         


Asn Leu Val Tyr Val Asn Ala Arg Tyr Thr Met Ala Tyr His Cys Ala 
        755                 760                 765             


Glu Arg Asp Thr Glu Leu Leu Leu Asn Ala Ala Gly Glu Gly Asn Leu 
    770                 775                 780                 


Leu Arg Arg Asp Arg Ser Trp Pro Ala Arg Leu His Leu Pro Arg Arg 
785                 790                 795                 800 


Ala Leu Ala Arg Arg Arg Asp Arg Val Glu Val Met Glu Arg Asp Val 
                805                 810                 815     


Ala Arg Gly Pro Glu Ala Tyr Asn Arg Asp Glu Trp Leu Gly Leu Val 
            820                 825                 830         


Arg Thr Leu Arg Arg Glu Lys Arg Val Cys Asp Asn Leu His Asn Asn 
        835                 840                 845             


Tyr Ala Tyr Leu Cys Gly Ala Asp Ala Glu Pro Gly Asp Ala Ser Leu 
    850                 855                 860                 


Ser Leu Leu Phe Val Tyr Arg Asn Lys Ala Ala His Leu Ser Val Leu 
865                 870                 875                 880 


Asn Lys Gly Gly Arg Leu Ser Gly Asp Leu Lys Glu Ala Lys Ser Trp 
                885                 890                 895     


Phe Tyr Val Tyr His Phe Leu Met Gln Arg Val Leu Glu Glu Glu Phe 
            900                 905                 910         


Arg Asn Thr Gln Ala Leu Pro Glu Arg Leu Arg Glu Leu Leu Met Met 
        915                 920                 925             


Ala Glu Arg Tyr Arg Gly Cys Ser Lys Asp Leu Ile Lys Val Leu Asn 
    930                 935                 940                 


Leu Thr Phe Ala Tyr Asn Leu Pro Arg Tyr Lys Asn Leu Ser Ile Asp 
945                 950                 955                 960 


Gly Arg Phe Asp Lys Asn His Pro Asp Pro Ser Asp Glu 
                965                 970             


<210>  203
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  203
ccactacacc cctgtcgaac aacgggggtc taaaac                                 36


<210>  204
<211>  854
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ga0129317_1008067

<400>  204

Met Lys Lys Gln Lys Lys Ser Leu Val Lys Ala Ala Gly Leu Lys Ser 
1               5                   10                  15      


Ala Phe Val Val Gly Asp Ser Val Tyr Leu Thr Ser Phe Gly Lys Gly 
            20                  25                  30          


Asn Ala Ala Arg Leu Asp Thr Lys Ile Asn Pro Asp Asn Ser Thr Glu 
        35                  40                  45              


Arg Tyr Val Ser Asp Ser Glu Lys His Thr Leu Lys Ile Asn Ser Ile 
    50                  55                  60                  


Thr Asp Thr Glu Leu Arg Leu Ser Gly Pro Phe Pro Lys Gln Ala Glu 
65                  70                  75                  80  


Ala Lys Asn Pro Thr His Lys Lys Asp Asn Glu Gln Lys Asn Thr Arg 
                85                  90                  95      


Gln Asp Met Leu Gly Leu Lys Ser Thr Leu Glu Lys Phe Tyr Phe Gly 
            100                 105                 110         


Ser Thr Phe Asp Asp Asn Ile His Ile Gln Ile Ile His Asn Ile Gln 
        115                 120                 125             


Asp Ile Ala Lys Ile Leu Ala Ala His Ser Asn Asn Ala Gly Tyr Ala 
    130                 135                 140                 


Leu Asp Asn Met Leu Ala Tyr Gln Gly Val Glu Phe Ser Asp Met Ile 
145                 150                 155                 160 


Gly Tyr Met Gly Thr Ser Arg Thr Phe Asp Asn Tyr Asp Pro Asn His 
                165                 170                 175     


Lys Asn Asn Lys Asp Phe Phe Arg Phe Leu Lys Leu Pro Arg Leu Gly 
            180                 185                 190         


Tyr Phe Gly Ser Ala Phe Tyr Ser Gln Lys Gly Lys Asp Phe Glu Lys 
        195                 200                 205             


Arg Ser Asp Glu Glu Val Tyr Asn Ile Cys Ala Leu Met Gly Gln Ile 
    210                 215                 220                 


Arg Gln Cys Cys Phe His Gly Lys Gln Glu Lys Tyr Gln Leu Lys Trp 
225                 230                 235                 240 


Leu Tyr Asn Phe His Asn Phe Lys Ser Asn Lys Pro Phe Leu Asp Thr 
                245                 250                 255     


Leu Asp Lys His Phe Asp Glu Met Ile Asp Arg Ile Asn Lys Asn Phe 
            260                 265                 270         


Ile Lys Asn Asn Thr Pro Asp Leu Ile Ile Leu Ser Gly Leu Tyr Pro 
        275                 280                 285             


Asp Met Ala Lys Lys Glu Leu Val Arg Leu Phe Tyr Asp Phe Thr Thr 
    290                 295                 300                 


Val Lys Glu Tyr Lys Asn Met Gly Phe Ser Val Lys Lys Leu Arg Glu 
305                 310                 315                 320 


Lys Met Leu Glu Ser Glu Glu Ala Ser Asp Phe Arg Asp Lys Asp Tyr 
                325                 330                 335     


Asp Ser Val Arg Arg Lys Leu Tyr Lys Leu Met Asp Phe Cys Ile Tyr 
            340                 345                 350         


Tyr Leu Tyr Tyr Ser Asp Ser Glu Arg Asn Glu Asn Leu Val Ser Arg 
        355                 360                 365             


Leu Arg Glu Ser Leu Thr Asp Glu Asn Lys Asp Ile Ile Tyr Ser Lys 
    370                 375                 380                 


Glu Ala Lys Ile Val Trp Asn Glu Leu Arg Lys Lys Phe Ser Thr Ile 
385                 390                 395                 400 


Leu Asp Asn Val Lys Gly Ser Asn Ile Lys Lys Leu Glu Asn Val Lys 
                405                 410                 415     


Glu Lys Phe Ile Ser Glu Asp Glu Phe Asp Asp Ile Lys Leu Asp Ile 
            420                 425                 430         


Asp Ile Ser Tyr Phe Ser Lys Leu Met Tyr Val Met Cys Tyr Phe Leu 
        435                 440                 445             


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Val Ser Lys Phe 
    450                 455                 460                 


Asp Asn Ile Gly Ser Ile Ile Glu Ala Ala Thr Gln Ile Gly Ile Asn 
465                 470                 475                 480 


Ile Glu Phe Ile Asp Asp Phe Lys Phe Phe Asp Arg Ser Lys Asp Ile 
                485                 490                 495     


Ser Val Glu Leu Asn Ile Ile Arg Asn Phe Ala Arg Met Gln Ala Pro 
            500                 505                 510         


Val Pro Asn Ala Lys Arg Ala Met Gln Glu Asp Ala Ile Arg Ile Leu 
        515                 520                 525             


Gly Gly Ser Glu Glu Asp Ile Phe Ser Ile Leu Asp Asp Met Thr Gly 
    530                 535                 540                 


Tyr Asp Lys Ser Gly Lys Lys Leu Ala Gln Ser Lys Lys Gly Phe Arg 
545                 550                 555                 560 


Asn Phe Ile Ile Asn Asn Val Val Glu Ser Ser Arg Phe Lys Tyr Ile 
                565                 570                 575     


Val Arg Tyr Ser Asn Pro Gln Lys Ile Arg Lys Leu Ala Asn Asn Ser 
            580                 585                 590         


Val Val Val Gly Phe Val Leu Gly Lys Leu Pro Asp Ala Gln Ile Glu 
        595                 600                 605             


Ser Tyr Phe Asn Ser Cys Leu Pro Asn Arg Val Tyr Ser Thr Pro Asp 
    610                 615                 620                 


Lys Ala Arg Glu Ser Leu Arg Asp Met Leu His Asn Ile Ser Phe Asn 
625                 630                 635                 640 


Asp Phe Ala Asp Val Lys Gln Asp Asp Arg Arg Ala Thr Pro Glu Glu 
                645                 650                 655     


Lys Val Glu Lys Glu Arg Tyr Lys Ala Ile Ile Gly Leu Tyr Leu Thr 
            660                 665                 670         


Val Met Tyr His Leu Val Lys Asn Leu Val Tyr Val Asn Ser Arg Tyr 
        675                 680                 685             


Val Met Ala Phe His Cys Leu Glu Arg Asp Ala Met His Tyr Asp Val 
    690                 695                 700                 


Ser Leu Asp Asn Tyr Arg Asp Leu Ile Arg His Leu Ile Ser Glu Gly 
705                 710                 715                 720 


Asp Ser Ser Cys Asn His Phe Ile Ser His Asn Arg Arg Met Arg Asp 
                725                 730                 735     


Cys Ile Glu Glu Asn Val Lys Asn Ser Glu Gln Leu Ile Phe Gly Lys 
            740                 745                 750         


Glu Asp Ala Val Ile Arg Phe Arg Asn Asn Val Ala His Leu Ser Ala 
        755                 760                 765             


Ile Arg Asn Ala Asn Glu Tyr Ile Gly Asp Ile Arg Glu Ile Thr Ser 
    770                 775                 780                 


Tyr Phe Ala Leu Tyr His Tyr Leu Met Gln Arg Lys Leu Ile Asp Asp 
785                 790                 795                 800 


Cys Lys Val Asn Asp Thr Ala His Lys Tyr Phe Glu Gln Leu Thr Lys 
                805                 810                 815     


Tyr Lys Thr Tyr Val Met Asp Met Val Lys Ala Leu Cys Ser Pro Phe 
            820                 825                 830         


Gly Tyr Asn Leu Pro Arg Phe Lys Asn Leu Ser Ile Glu Gly Lys Phe 
        835                 840                 845             


Asp Met His Glu Ser Lys 
    850                 


<210>  205
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  205
gaactacact actgtaattt tgcagtagtc taaaac                                 36


<210>  206
<211>  965
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ga0224415_10048792

<400>  206

Met Ser Lys Lys Glu Asn Arg Lys Ser Tyr Val Lys Gly Leu Gly Leu 
1               5                   10                  15      


Lys Ser Thr Leu Val Ser Asp Ser Lys Val Tyr Leu Thr Thr Phe Ala 
            20                  25                  30          


Asp Gly Ser Asn Ala Lys Leu Glu Lys Cys Val Glu Asn Asn Lys Ile 
        35                  40                  45              


Ile Cys Ile Ser Asn Asp Lys Glu Ala Phe Ala Ala Ser Ile Ala Asn 
    50                  55                  60                  


Lys Asn Val Gly Tyr Lys Ile Lys Asn Asp Glu Lys Phe Arg His Pro 
65                  70                  75                  80  


Lys Gly Tyr Asp Ile Ile Ser Asn Asn Pro Leu Leu His Asn Asn Ser 
                85                  90                  95      


Val Gln Gln Asp Met Leu Gly Leu Lys Asn Val Leu Glu Lys Arg Tyr 
            100                 105                 110         


Phe Gly Lys Ser Ser Gly Gly Asp Asn Asn Leu Cys Ile Gln Ile Ile 
        115                 120                 125             


His Asn Ile Ile Asp Ile Glu Lys Ile Leu Ser Glu Tyr Ile Pro Asn 
    130                 135                 140                 


Val Val Tyr Ala Phe Asn Asn Ile Ala Gly Phe Lys Asp Glu His Asn 
145                 150                 155                 160 


Asn Ile Ile Asp Ile Ile Gly Thr Gln Thr Tyr Asn Ser Ser Tyr Thr 
                165                 170                 175     


Tyr Ala Asp Phe Ser Lys Asp Lys Ser Asp Lys Lys Tyr Ile Glu Phe 
            180                 185                 190         


Gln Lys Leu Leu Lys Asn Lys Arg Leu Gly Tyr Trp Gly Lys Ala Phe 
        195                 200                 205             


Phe Thr Gly Gln Gly Asn Asn Ala Lys Val Arg Gln Glu Asn Gln Cys 
    210                 215                 220                 


Phe His Ile Ile Ala Leu Leu Ile Ser Leu Arg Asn Trp Ala Thr His 
225                 230                 235                 240 


Ser Asn Glu Leu Asp Lys His Thr Lys Arg Thr Trp Leu Tyr Lys Leu 
                245                 250                 255     


Asp Asp Thr Asn Ile Leu Asn Ala Glu Tyr Val Lys Thr Leu Asn Tyr 
            260                 265                 270         


Leu Tyr Asp Thr Ile Ala Asp Glu Leu Thr Lys Ser Phe Ser Lys Asn 
        275                 280                 285             


Gly Ala Val Asn Val Asn Tyr Leu Ala Lys Lys Tyr Asn Ile Lys Asp 
    290                 295                 300                 


Asp Leu Pro Gly Phe Ser Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys 
305                 310                 315                 320 


Glu Gln Lys Asn Leu Gly Phe Asn Ile Ser Lys Leu Arg Glu Asn Met 
                325                 330                 335     


Leu Asp Phe Lys Asp Met Ser Val Ile Arg Asp Asp His Asn Arg Tyr 
            340                 345                 350         


Asp Lys Asp Arg Ser Lys Ile Tyr Thr Met Met Asp Phe Val Ile Tyr 
        355                 360                 365             


Arg Tyr Tyr Ile Asp Asn Asn Asn Asp Ser Ile Asp Phe Ile Asn Lys 
    370                 375                 380                 


Leu Arg Ser Ser Ile Asp Glu Lys Ser Lys Glu Lys Leu Tyr Asn Glu 
385                 390                 395                 400 


Glu Ala Asn Arg Leu Trp Asn Lys Leu Lys Glu Tyr Met Leu Tyr Ile 
                405                 410                 415     


Lys Glu Phe Asn Gly Lys Leu Ala Ser Arg Thr Pro Asp Arg Asp Gly 
            420                 425                 430         


Asn Ile Ser Glu Phe Val Glu Ser Leu Pro Lys Ile His Arg Leu Leu 
        435                 440                 445             


Pro Arg Gly Gln Lys Ile Ser Asn Phe Ser Lys Leu Met Tyr Leu Leu 
    450                 455                 460                 


Thr Met Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu 
465                 470                 475                 480 


Ile Asn Lys Phe Glu Asn Ile Gln Gly Phe Leu Asp Ile Met Pro Glu 
                485                 490                 495     


Ile Asn Val Asn Ala Lys Phe Glu Pro Glu Tyr Val Phe Phe Asn Lys 
            500                 505                 510         


Ser His Glu Ile Ala Gly Glu Leu Lys Leu Ile Lys Gly Phe Ala Gln 
        515                 520                 525             


Met Gly Glu Pro Ala Ala Thr Leu Lys Leu Glu Met Thr Ala Asp Ala 
    530                 535                 540                 


Ile Lys Ile Leu Gly Thr Glu Lys Glu Asp Ala Glu Leu Ile Lys Leu 
545                 550                 555                 560 


Ala Glu Ser Leu Phe Lys Asp Glu Asn Gly Lys Leu Leu Gly Asn Lys 
                565                 570                 575     


Gln His Gly Met Arg Asn Phe Ile Gly Asn Asn Val Ile Lys Ser Lys 
            580                 585                 590         


Arg Phe His Tyr Leu Ile Arg Tyr Gly Asp Pro Ala His Leu His Lys 
        595                 600                 605             


Ile Ala Thr Asn Lys Asn Val Val Arg Phe Val Leu Gly Arg Ile Ala 
    610                 615                 620                 


Asp Met Gln Lys Lys Gln Gly Gln Lys Gly Lys Asn Gln Ile Asp Arg 
625                 630                 635                 640 


Tyr Tyr Glu Val Cys Val Gly Asn Lys Asp Ile Lys Lys Thr Ile Glu 
                645                 650                 655     


Glu Lys Ile Asp Ala Leu Thr Asp Ile Ile Val Asn Met Asn Tyr Asp 
            660                 665                 670         


Gln Phe Glu Lys Lys Lys Ala Val Ile Glu Asn Gln Asn Arg Gly Lys 
        675                 680                 685             


Thr Phe Glu Glu Lys Asn Lys Tyr Lys Arg Asp Asn Ala Glu Arg Glu 
    690                 695                 700                 


Lys Phe Lys Lys Ile Ile Ser Leu Tyr Leu Thr Val Ile Tyr His Ile 
705                 710                 715                 720 


Leu Lys Asn Ile Val Asn Val Asn Ser Arg Tyr Ile Leu Gly Phe His 
                725                 730                 735     


Cys Leu Glu Arg Asp Lys Gln Leu Tyr Ile Glu Lys Tyr Asn Lys Asp 
            740                 745                 750         


Lys Leu Asp Gly Phe Val Ala Leu Thr Lys Phe Cys Leu Gly Asp Glu 
        755                 760                 765             


Glu Arg Phe Glu Asp Leu Lys Ala Lys Ala Gln Ala Ser Ile Gln Ala 
    770                 775                 780                 


Leu Glu Thr Ala Asn Pro Lys Leu Tyr Ala Lys Tyr Met Asn Tyr Ser 
785                 790                 795                 800 


Asp Glu Glu Lys Lys Glu Glu Phe Lys Lys Gln Leu Asn Arg Glu Arg 
                805                 810                 815     


Val Lys Asn Ala Arg Asn Ala Tyr Leu Lys Asn Ile Lys Asn Tyr Ile 
            820                 825                 830         


Met Ile Arg Leu Gln Leu Arg Asp Gln Thr Asp Ser Ser Gly Tyr Leu 
        835                 840                 845             


Cys Gly Glu Phe Arg Asp Lys Val Ala His Leu Glu Val Ala Arg His 
    850                 855                 860                 


Ala His Glu Tyr Ile Gly Asn Ile Lys Glu Val Asn Ser Tyr Phe Gln 
865                 870                 875                 880 


Leu Tyr His Tyr Ile Met Gln Cys Arg Leu Tyr Asp Val Leu Lys Asn 
                885                 890                 895     


Asn Thr Lys Ala Glu Ala Met Val Lys Gly Lys Ala Lys Glu Tyr Phe 
            900                 905                 910         


Glu Ala Leu Glu Lys Glu Gly Thr Tyr Asn Asp Lys Leu Leu Lys Ile 
        915                 920                 925             


Ala Cys Val Pro Phe Gly Tyr Cys Ile Pro Arg Tyr Lys Asn Leu Ser 
    930                 935                 940                 


Met Glu Glu Leu Phe Asp Met Asn Glu Glu Lys Lys Phe Lys Lys Lys 
945                 950                 955                 960 


Ala Pro Glu Asn Thr 
                965 


<210>  207
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  207
caagtaaacc cctaccaaat gtaaggggtt tgaaac                                 36


<210>  208
<211>  1022
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  160582958 _gene49834

<400>  208

Met Lys Asn Ser Val Thr Phe Lys Leu Ile Gln Ala Gln Glu Asn Lys 
1               5                   10                  15      


Glu Ala Ala Arg Lys Lys Ala Lys Asp Ile Ala Glu Gln Ala Arg Ile 
            20                  25                  30          


Ala Lys Arg Asn Gly Val Val Lys Lys Glu Glu Asn Arg Ile Asn Arg 
        35                  40                  45              


Ile Gln Ile Glu Ile Gln Thr Gln Lys Lys Ser Asn Thr Gln Asn Ala 
    50                  55                  60                  


Tyr His Leu Lys Ser Leu Ala Lys Ala Ala Gly Val Lys Ser Val Phe 
65                  70                  75                  80  


Ala Ile Gly Asn Asp Leu Leu Met Thr Gly Phe Gly Pro Gly Asn Asp 
                85                  90                  95      


Ala Thr Ile Glu Lys Arg Val Phe Gln Asn Arg Ala Ile Glu Thr Leu 
            100                 105                 110         


Ser Ser Pro Glu Gln Tyr Ser Ala Glu Phe Gln Asn Lys Gln Phe Lys 
        115                 120                 125             


Ile Lys Gly Asn Ile Lys Val Leu Asn His Ser Thr Gln Lys Met Glu 
    130                 135                 140                 


Glu Ile Gln Thr Glu Leu Gln Asp Asn Tyr Asn Arg Pro His Phe Asp 
145                 150                 155                 160 


Leu Leu Gly Cys Lys Asn Val Leu Glu Gln Lys Tyr Phe Gly Arg Thr 
                165                 170                 175     


Phe Ser Asp Asn Ile His Val Gln Ile Ala Tyr Asn Ile Met Asp Ile 
            180                 185                 190         


Glu Lys Leu Leu Thr Pro Tyr Ile Asn Asn Ile Ile Tyr Thr Leu Asn 
        195                 200                 205             


Glu Leu Met Arg Asp Asn Ser Lys Asp Asp Phe Phe Gly Cys Asp Ser 
    210                 215                 220                 


His Phe Ser Val Ala Tyr Leu Tyr Asp Glu Leu Lys Ala Gly Tyr Ser 
225                 230                 235                 240 


Asp Arg Leu Lys Thr Lys Pro Asn Leu Ser Lys Asn Ile Asp Arg Ile 
                245                 250                 255     


Trp Asn Asn Phe Cys Asn Tyr Met Asn Ser Asp Ser Gly Asn Thr Glu 
            260                 265                 270         


Ala Arg Leu Ala Tyr Phe Gly Glu Leu Phe Tyr Lys Pro Lys Glu Thr 
        275                 280                 285             


Gly Asp Ala Lys Ser Asp Tyr Lys Thr His Leu Ser Asn Asn Gln Lys 
    290                 295                 300                 


Glu Glu Trp Glu Leu Lys Ser Asp Lys Glu Val Tyr Asn Ile Phe Ala 
305                 310                 315                 320 


Ile Leu Cys Asp Leu Arg His Phe Cys Thr His Gly Glu Ser Ile Thr 
                325                 330                 335     


Pro Ser Gly Lys Pro Phe Pro Tyr Asn Leu Glu Lys Asn Leu Phe Pro 
            340                 345                 350         


Glu Ala Lys Gln Val Leu Asn Ser Leu Phe Glu Glu Lys Ala Glu Ser 
        355                 360                 365             


Leu Gly Ala Glu Ala Phe Gly Lys Thr Ala Gly Lys Thr Asp Val Ser 
    370                 375                 380                 


Ile Leu Leu Lys Val Phe Glu Lys Glu Gln Ala Ser Gln Lys Glu Gln 
385                 390                 395                 400 


Gln Ala Leu Leu Lys Glu Tyr Tyr Asp Phe Lys Val Gln Lys Thr Tyr 
                405                 410                 415     


Lys Asn Met Gly Phe Ser Ile Lys Lys Leu Arg Glu Ala Ile Met Glu 
            420                 425                 430         


Ile Pro Asp Ala Ala Lys Phe Lys Asp Asp Leu Tyr Ser Ser Leu Arg 
        435                 440                 445             


His Lys Leu Tyr Gly Leu Phe Asp Phe Ile Leu Val Lys His Phe Leu 
    450                 455                 460                 


Asp Thr Ser Asp Ser Glu Asn Leu Gln Asn Asn Asp Ile Phe Arg Gln 
465                 470                 475                 480 


Leu Arg Ala Cys Arg Cys Glu Glu Glu Lys Asp Gln Val Tyr Arg Ser 
                485                 490                 495     


Ile Ala Val Lys Val Trp Glu Lys Val Lys Lys Lys Glu Leu Asn Met 
            500                 505                 510         


Phe Lys Gln Val Val Val Ile Pro Ser Leu Ser Lys Asp Glu Leu Lys 
        515                 520                 525             


Gln Met Glu Met Thr Lys Asn Thr Glu Leu Leu Ser Ser Ile Glu Thr 
    530                 535                 540                 


Ile Ser Thr Gln Ala Ser Leu Phe Ser Glu Met Ile Phe Met Met Thr 
545                 550                 555                 560 


Tyr Leu Leu Asp Gly Lys Glu Ile Asn Leu Leu Cys Thr Ser Leu Ile 
                565                 570                 575     


Glu Lys Phe Glu Asn Ile Ala Ser Phe Asn Glu Val Leu Lys Ser Pro 
            580                 585                 590         


Gln Ile Gly Tyr Glu Thr Lys Tyr Thr Glu Gly Tyr Ala Phe Phe Lys 
        595                 600                 605             


Asn Ala Asp Lys Thr Ala Lys Glu Leu Arg Gln Val Asn Asn Met Ala 
    610                 615                 620                 


Arg Met Thr Lys Pro Leu Gly Gly Val Asn Thr Lys Cys Val Met Tyr 
625                 630                 635                 640 


Asn Glu Ala Ala Lys Ile Leu Gly Ala Lys Pro Met Ser Lys Ala Glu 
                645                 650                 655     


Leu Glu Ser Val Phe Asn Leu Asp Asn His Asp Tyr Thr Tyr Ser Pro 
            660                 665                 670         


Ser Gly Lys Lys Ile Pro Asn Lys Asn Phe Arg Asn Phe Ile Ile Asn 
        675                 680                 685             


Asn Val Ile Thr Ser Arg Arg Phe Leu Tyr Leu Ile Arg Tyr Gly Asn 
    690                 695                 700                 


Pro Glu Lys Ile Arg Lys Ile Ala Ile Asn Pro Ser Ile Ile Ser Phe 
705                 710                 715                 720 


Val Leu Lys Gln Ile Pro Asp Glu Gln Ile Lys Arg Tyr Tyr Pro Pro 
                725                 730                 735     


Cys Ile Gly Lys Arg Thr Asp Asp Val Thr Leu Met Arg Asp Glu Leu 
            740                 745                 750         


Gly Lys Met Leu Gln Ser Val Asn Phe Glu Gln Phe Ser Arg Val Asn 
        755                 760                 765             


Asn Lys Gln Asn Ala Lys Gln Asn Pro Asn Gly Glu Lys Ala Arg Leu 
    770                 775                 780                 


Gln Ala Cys Val Arg Leu Tyr Leu Thr Val Pro Tyr Leu Phe Ile Lys 
785                 790                 795                 800 


Asn Met Val Asn Ile Asn Ala Arg Tyr Val Leu Ala Phe His Cys Leu 
                805                 810                 815     


Glu Arg Asp His Ala Leu Cys Phe Asn Ser Arg Lys Leu Asn Asp Asp 
            820                 825                 830         


Ser Tyr Asn Glu Met Ala Asn Lys Phe Gln Met Val Arg Lys Ala Lys 
        835                 840                 845             


Lys Glu Gln Tyr Glu Lys Glu Tyr Lys Cys Lys Lys Gln Glu Thr Gly 
    850                 855                 860                 


Thr Ala His Thr Lys Lys Ile Glu Lys Leu Asn Gln Gln Ile Ala Tyr 
865                 870                 875                 880 


Ile Asp Lys Asp Ile Lys Asn Met His Ser Tyr Thr Cys Arg Asn Tyr 
                885                 890                 895     


Arg Asn Leu Val Ala His Leu Asn Val Val Ser Lys Leu Gln Asn Tyr 
            900                 905                 910         


Val Ser Glu Leu Pro Asn Asp Tyr Gln Ile Thr Ser Tyr Phe Ser Phe 
        915                 920                 925             


Tyr His Tyr Cys Met Gln Leu Gly Leu Met Glu Lys Val Ser Ser Lys 
    930                 935                 940                 


Asn Ile Pro Leu Val Glu Ser Leu Lys Asn Glu Ala Asn Asp Ala Gln 
945                 950                 955                 960 


Ser Tyr Ser Ala Lys Lys Thr Leu Glu Tyr Phe Asp Leu Ile Glu Lys 
                965                 970                 975     


Asn Arg Thr Tyr Cys Lys Asp Phe Leu Lys Ala Leu Asn Ala Pro Phe 
            980                 985                 990         


Ser Tyr Asn Leu Pro Arg Phe Lys  Asn Leu Ser Ile Glu  Ala Leu Phe 
        995                 1000                 1005             


Asp Lys  Asn Ile Val Tyr Glu  Gln Ala Asp Leu Lys  Lys Glu 
    1010                 1015                 1020         


<210>  209
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  209
gaactacacc cctctgttct tgtaggggtc taacac                                 36


<210>  210
<211>  998
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  250twins_35838_GL0110300

<400>  210

Met Gly Asn Lys Gln Arg Val Ser Ala Gln Lys Arg Arg Glu Asn Ala 
1               5                   10                  15      


Lys Leu Cys Asn Gln Gln Lys Ala Arg Gln Ala Glu Ser Gln Arg Asp 
            20                  25                  30          


Lys Ile Lys Asn Met Asn Val Glu Lys Met Lys Asn Ile Asn Thr Asn 
        35                  40                  45              


Asp Ile Lys His Thr Lys Thr Thr Ala Lys Lys Leu Gly Leu Lys Ser 
    50                  55                  60                  


Thr Ile Ile Ala Asp Lys Lys Ile Ile Leu Thr Ser Phe Ile Asn Glu 
65                  70                  75                  80  


Gln Ser Ser Lys Thr Ala Asn Ile Glu Lys Val Ala Gly Phe Lys Gly 
                85                  90                  95      


Asp Thr Ile Asp Thr Ile Ser Tyr Thr Pro Arg Met Phe Arg Ser Glu 
            100                 105                 110         


Ile Asn Pro Gly Glu Ile Val Ile Ser Lys Gly Asp Asp Leu Ser Glu 
        115                 120                 125             


Phe Ala Asn Pro Ala Asn Phe Pro Ile Gly Arg Asp Tyr Val Lys Ile 
    130                 135                 140                 


Arg Ser Ala Leu Glu Lys Gln Tyr Phe Gly Lys Glu Phe Pro Glu Asp 
145                 150                 155                 160 


Asn Leu His Val Gln Ile Ala Tyr Asn Val Ala Asp Ile Lys Lys Ile 
                165                 170                 175     


Leu Ser Val Tyr Ile Asn Asn Ile Ile Tyr Met Phe Tyr Asn Leu Ala 
            180                 185                 190         


Arg Ser Glu Glu Tyr Asp Ile Phe Tyr Asn Ser Gln Ser Glu Asn Ser 
        195                 200                 205             


Gly Arg Asp Cys Asp Val Ile Gly Ser Leu Tyr Tyr Gln Ala Ser Tyr 
    210                 215                 220                 


Arg Asn Gln Asp Ala Asn Arg Phe Glu Lys Asp Gly Lys Lys Lys Ala 
225                 230                 235                 240 


Ile Asp Ser Leu Leu Asp Asp Thr Arg Ala Tyr Tyr Thr Tyr Phe Asp 
                245                 250                 255     


Gly Leu Phe Ser Val Pro Lys Arg Glu Asp Asp Gly Lys Ile Lys Glu 
            260                 265                 270         


Ser Glu Lys Glu Lys Ala Lys Asp Gln Asn Phe Asp Val Leu Arg Leu 
        275                 280                 285             


Leu Ser Val Gly Arg Gln Leu Thr Phe His Ser Asp Lys Ser Asn Asn 
    290                 295                 300                 


Glu Ala Tyr Leu Phe Asp Leu Ser Lys Leu Thr Arg Ala Ala Gln Asp 
305                 310                 315                 320 


Glu Asn Arg Arg Gln Asp Ile Gln Ser Leu Leu Asn Ile Leu Asn Ser 
                325                 330                 335     


Thr Cys Arg Ser Asn Leu Glu Gly Val Asn Gly Asp Phe Val Lys His 
            340                 345                 350         


Ala Lys Asn Asn Leu Tyr Val Leu Asn Gln Leu Tyr Pro Ser Leu Lys 
        355                 360                 365             


Ala Asn Asp Leu Ile Gly Glu Tyr Tyr Asn Phe Ile Val Lys Lys Glu 
    370                 375                 380                 


Asn Arg Asn Ile Gly Ile Arg Leu Ile Thr Val Arg Glu Leu Ile Ile 
385                 390                 395                 400 


Glu His Asn Tyr Thr Asn Leu Lys Asp Ser Lys Tyr Asp Thr Tyr Arg 
                405                 410                 415     


Asn Lys Ile Tyr Thr Val Leu Asn Phe Ile Leu Phe Arg Glu Ile Gln 
            420                 425                 430         


Glu Asn Ser Ile Ala Ile Lys Asn Phe Arg Glu Lys Leu Arg Ser Thr 
        435                 440                 445             


Glu Lys Ala Glu Gln Pro Ala Leu Tyr Gln Ala Phe Ala Asn Lys Ile 
    450                 455                 460                 


Tyr Pro Met Val Gln Ala Lys Phe Ala Lys Ala Ile Asp Leu Phe Glu 
465                 470                 475                 480 


Glu Gln Tyr Lys Thr Lys Phe Lys Ser Glu Phe Lys Gly Gly Ile Ser 
                485                 490                 495     


Ile Glu Asn Met Gln Gln Gln Asn Ile Leu Leu Gln Thr Glu Asn Ile 
            500                 505                 510         


Asp Tyr Phe Ser Lys Tyr Val Leu Phe Leu Thr Lys Phe Leu Asp Gly 
        515                 520                 525             


Lys Glu Ile Asn Glu Leu Leu Cys Ala Leu Ile Asn Lys Phe Asp Asn 
    530                 535                 540                 


Ile Ala Asp Leu Leu Asp Ile Ser Lys Gln Ile Gly Thr Pro Val Val 
545                 550                 555                 560 


Phe Cys Ala Asp Tyr Glu Ser Leu Asn Asp Ala Ala Lys Ile Ala Glu 
                565                 570                 575     


Asn Ile Arg Leu Ile Lys Asn Ile Ala His Leu Arg Pro Ala Ile Gln 
            580                 585                 590         


Glu Ala Gln Ser Ser Lys Asp Asn Ala Asp Ala Ala Gly Thr Pro Ala 
        595                 600                 605             


Thr Leu Leu Ile Asp Ala Tyr Asn Met Leu Asn Thr Asp Ile Gln Leu 
    610                 615                 620                 


Val Tyr Gly Glu Ala Ala Tyr Glu Glu Leu Arg Lys Asp Leu Phe Glu 
625                 630                 635                 640 


Arg Lys Asn Gly Thr Lys Tyr Asn Lys Lys Gly Lys Lys Val Asp Val 
                645                 650                 655     


Tyr Asp His Lys Phe Arg Asn Phe Leu Ile Asn Asn Val Ile Lys Ser 
            660                 665                 670         


Lys Trp Phe Phe Tyr Ile Ala Lys Tyr Val Lys Pro Ala Asp Cys Ala 
        675                 680                 685             


Lys Met Met Ser Asn Lys Lys Met Ile Glu Phe Ala Leu Arg Asp Leu 
    690                 695                 700                 


Pro Glu Thr Gln Ile Lys Arg Tyr Tyr Tyr Thr Ile Thr Gly Asn Glu 
705                 710                 715                 720 


Ala Leu Gly Asp Ala Glu Ser Leu Lys Gly Val Ile Ile Glu Gln Leu 
                725                 730                 735     


His Ala Phe Ser Ile Lys Asn Thr Leu Leu Ser Ile Lys Asn Met Gly 
            740                 745                 750         


Glu Gly Glu Tyr Lys Ile Gln Gln Ile Gly Ser Ser Lys Glu Lys Leu 
        755                 760                 765             


Lys Ala Ile Val Asn Leu Tyr Leu Thr Val Ala Tyr Leu Leu Thr Lys 
    770                 775                 780                 


Ser Leu Val Lys Val Asn Ile Arg Phe Ser Ile Ala Phe Gly Cys Leu 
785                 790                 795                 800 


Glu Arg Asp Leu Val Leu Gln Lys Lys Ser Glu Lys Lys Phe Asp Ala 
                805                 810                 815     


Ile Ile Asn Glu Ile Leu Leu Glu Asp Asp Lys Ile Arg Lys Glu Cys 
            820                 825                 830         


Asp Lys Glu Arg Ala Gln Ala Lys Thr Leu Pro Arg Glu Leu Ala Gln 
        835                 840                 845             


Glu Arg Phe Ala Gln Ile Lys Arg Arg Glu Ser Gly Cys Tyr Phe Lys 
    850                 855                 860                 


Ser Tyr His Val Tyr Asp Tyr Leu Ser Lys Asn Ser Asn Glu Phe Lys 
865                 870                 875                 880 


Gln Asn His Ile Asp Phe Ala Val Thr Ser Tyr Arg Asn Asn Val Glu 
                885                 890                 895     


His Leu Asn Val Val His Cys Met Thr Lys Tyr Phe Ser Glu Val Lys 
            900                 905                 910         


Asp Val Lys Ser Tyr Tyr Gly Val Tyr Cys Tyr Ile Met Gln Arg Met 
        915                 920                 925             


Leu Cys Asp Glu Leu Ile Ile Lys Asn Gln Asp Lys Pro Asp Val Arg 
    930                 935                 940                 


Gln Thr Phe Glu Glu Tyr Asn Arg Leu Leu Lys Asp His Gly Thr Tyr 
945                 950                 955                 960 


Ser Lys Asn Leu Met Trp Leu Leu Asn Phe Pro Phe Ala Tyr Asn Leu 
                965                 970                 975     


Ala Arg Tyr Lys Asn Leu Ser Asn Glu Asp Leu Phe Asn Ala Lys Asn 
            980                 985                 990         


Asn Asp Gln Lys Ser Lys 
        995             


<210>  211
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  211
gtacaatagc ccgttgaaat agatgggttc taagac                                 36


<210>  212
<211>  1020
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  250twins_36050_GL0158985

<400>  212

Met Lys Lys Lys His Gln Ser Ala Ala Glu Lys Arg Gln Val Lys Lys 
1               5                   10                  15      


Leu Lys Asn Gln Glu Lys Ala Gln Lys Tyr Ala Ser Glu Pro Ser Pro 
            20                  25                  30          


Leu Gln Ser Asp Thr Ala Gly Val Glu Cys Ser Gln Lys Lys Thr Val 
        35                  40                  45              


Val Ser His Ile Ala Ser Ser Lys Thr Leu Ala Lys Ala Met Gly Leu 
    50                  55                  60                  


Lys Ser Thr Leu Val Met Gly Asp Lys Leu Val Ile Thr Ser Phe Ala 
65                  70                  75                  80  


Ala Ser Lys Ala Val Gly Gly Ala Gly Tyr Lys Ser Ala Asn Ile Glu 
                85                  90                  95      


Lys Ile Thr Asp Leu Gln Gly Arg Val Ile Glu Glu His Glu Arg Met 
            100                 105                 110         


Phe Ser Ala Asp Val Gly Glu Lys Asn Ile Glu Leu Ser Lys Asn Asp 
        115                 120                 125             


Cys His Thr Asn Val Asn Asn Pro Val Val Thr Asn Ile Gly Lys Asp 
    130                 135                 140                 


Tyr Ile Gly Leu Lys Ser Arg Leu Glu Gln Glu Phe Phe Gly Lys Thr 
145                 150                 155                 160 


Phe Glu Asn Asp Asn Leu His Val Gln Leu Ala Tyr Asn Ile Leu Asp 
                165                 170                 175     


Ile Lys Lys Ile Leu Gly Thr Tyr Val Asn Asn Ile Ile Tyr Ile Phe 
            180                 185                 190         


Tyr Asn Leu Asn Arg Ala Gly Thr Gly Arg Asp Glu Arg Met Tyr Asp 
        195                 200                 205             


Asp Leu Ile Gly Thr Leu Tyr Ala Tyr Lys Pro Met Glu Ala Gln Gln 
    210                 215                 220                 


Thr Tyr Leu Leu Lys Gly Asp Lys Asp Met Arg Arg Phe Glu Glu Val 
225                 230                 235                 240 


Lys Gln Leu Leu Gln Asn Thr Ser Ala Tyr Tyr Val Tyr Tyr Gly Thr 
                245                 250                 255     


Leu Phe Glu Lys Val Lys Ala Lys Ser Lys Lys Glu Gln Arg Ala Lys 
            260                 265                 270         


Glu Ala Glu Ile Asp Ala Cys Thr Ala His Asn Tyr Asp Val Leu Arg 
        275                 280                 285             


Leu Leu Ser Leu Met Arg Gln Leu Cys Met His Ser Val Ala Gly Thr 
    290                 295                 300                 


Ala Phe Lys Leu Ala Glu Ser Ala Leu Phe Asn Ile Glu Asp Val Leu 
305                 310                 315                 320 


Ser Ala Asp Leu Lys Glu Ile Leu Asp Glu Ala Phe Ser Gly Ala Val 
                325                 330                 335     


Asn Lys Leu Asn Asp Gly Phe Val Gln His Ser Gly Asn Asn Leu Tyr 
            340                 345                 350         


Val Leu Gln Gln Leu Tyr Pro Asn Glu Thr Ile Glu Arg Ile Ala Glu 
        355                 360                 365             


Lys Tyr Tyr Arg Leu Thr Val Arg Lys Glu Asp Leu Asn Met Gly Val 
    370                 375                 380                 


Asn Ile Lys Lys Leu Arg Glu Leu Ile Val Gly Gln Tyr Phe Pro Glu 
385                 390                 395                 400 


Val Leu Asp Lys Glu Tyr Asp Leu Ser Lys Asn Gly Asp Ser Val Val 
                405                 410                 415     


Thr Tyr Arg Ser Lys Ile Tyr Thr Val Met Asn Tyr Ile Leu Leu Tyr 
            420                 425                 430         


Tyr Leu Glu Asp His Asp Ser Ser Arg Glu Ser Met Val Glu Ala Leu 
        435                 440                 445             


Arg Gln Asn Arg Glu Gly Asp Glu Gly Lys Glu Glu Ile Tyr Arg Gln 
    450                 455                 460                 


Phe Ala Lys Lys Val Trp Asn Gly Val Ser Gly Leu Phe Gly Val Cys 
465                 470                 475                 480 


Leu Asn Leu Phe Lys Thr Glu Lys Arg Asn Lys Phe Arg Ser Lys Val 
                485                 490                 495     


Ala Leu Pro Asp Val Ser Gly Ala Ala Tyr Met Leu Ser Ser Glu Asn 
            500                 505                 510         


Ile Asp Tyr Phe Val Lys Met Leu Phe Phe Val Cys Lys Phe Leu Asp 
        515                 520                 525             


Gly Lys Glu Ile Asn Glu Leu Leu Cys Ala Leu Ile Asn Lys Phe Asp 
    530                 535                 540                 


Asn Ile Ala Asp Ile Leu Asp Ala Ala Ala Gln Cys Gly Ser Ser Val 
545                 550                 555                 560 


Trp Phe Val Asp Ser Tyr Arg Phe Phe Glu Arg Ser Arg Arg Ile Ser 
                565                 570                 575     


Ala Gln Ile Arg Ile Val Lys Asn Ile Ala Ser Lys Asp Phe Lys Lys 
            580                 585                 590         


Ser Lys Lys Asp Ser Asp Glu Ser Tyr Pro Glu Gln Leu Tyr Leu Asp 
        595                 600                 605             


Ala Leu Ala Leu Leu Gly Asp Val Ile Ser Lys Tyr Lys Gln Asn Arg 
    610                 615                 620                 


Asp Gly Ser Val Val Ile Asp Asp Gln Gly Asn Ala Val Leu Thr Glu 
625                 630                 635                 640 


Gln Tyr Lys Arg Phe Arg Tyr Glu Phe Phe Glu Glu Ile Lys Arg Asp 
                645                 650                 655     


Glu Ser Gly Gly Ile Lys Tyr Lys Lys Ser Gly Lys Pro Glu Tyr Asn 
            660                 665                 670         


His Gln Arg Arg Asn Phe Ile Leu Asn Asn Val Leu Lys Ser Lys Trp 
        675                 680                 685             


Phe Phe Tyr Val Val Lys Tyr Asn Arg Pro Ser Ser Cys Arg Glu Leu 
    690                 695                 700                 


Met Lys Asn Lys Glu Ile Leu Arg Phe Val Leu Arg Asp Ile Pro Asp 
705                 710                 715                 720 


Ser Gln Val Arg Arg Tyr Phe Lys Ala Val Gln Gly Glu Glu Ala Tyr 
                725                 730                 735     


Ala Ser Ala Glu Ala Met Arg Thr Arg Leu Val Asp Ala Leu Ser Gln 
            740                 745                 750         


Phe Ser Val Thr Ala Cys Leu Asp Glu Val Gly Gly Met Thr Asp Lys 
        755                 760                 765             


Glu Phe Ala Ser Gln Arg Ala Val Asp Ser Lys Glu Lys Leu Arg Ala 
    770                 775                 780                 


Ile Ile Arg Leu Tyr Leu Thr Val Ala Tyr Leu Ile Thr Lys Ser Met 
785                 790                 795                 800 


Val Lys Val Asn Thr Arg Phe Ser Ile Ala Phe Ser Val Leu Glu Arg 
                805                 810                 815     


Asp Tyr Tyr Leu Leu Ile Asp Gly Lys Lys Lys Ser Ser Asp Tyr Thr 
            820                 825                 830         


Gly Glu Asp Met Leu Ala Leu Thr Arg Lys Phe Val Gly Glu Asp Ala 
        835                 840                 845             


Gly Leu Tyr Arg Glu Trp Lys Glu Lys Asn Ala Glu Ala Lys Asp Lys 
    850                 855                 860                 


Tyr Phe Asp Lys Ala Glu Arg Lys Lys Val Leu Arg Gln Asn Asp Lys 
865                 870                 875                 880 


Met Ile Arg Lys Met His Phe Thr Pro His Ser Leu Asn Tyr Val Gln 
                885                 890                 895     


Lys Asn Leu Glu Ser Val Gln Ser Asn Gly Leu Ala Ala Val Ile Lys 
            900                 905                 910         


Glu Tyr Arg Asn Ala Val Ala His Leu Asn Ile Ile Asn Arg Leu Asp 
        915                 920                 925             


Glu Tyr Ile Gly Ser Ala Arg Ala Asp Ser Tyr Tyr Ser Leu Tyr Cys 
    930                 935                 940                 


Tyr Cys Leu Gln Met Tyr Leu Ser Lys Asn Phe Ser Val Gly Tyr Leu 
945                 950                 955                 960 


Ile Asn Val Gln Lys Gln Leu Glu Glu His His Thr Tyr Met Lys Asp 
                965                 970                 975     


Leu Met Trp Leu Leu Asn Ile Pro Phe Ala Tyr Asn Leu Ala Arg Tyr 
            980                 985                 990         


Lys Asn Leu Ser Asn Glu Lys Leu  Phe Tyr Asp Glu Glu  Ala Ala Ala 
        995                 1000                 1005             


Glu Lys  Ala Asp Lys Ala Glu  Asn Glu Arg Gly Glu  
    1010                 1015                 1020 


<210>  213
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  213
gtacaatagc cctgcagtaa ggcagggttc taagac                                 36


<210>  214
<211>  903
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  31009_GL0034153

<400>  214

Met Gly Ser Arg Gly Val Ile Ile Met Thr Glu Lys Arg Lys Ser Arg 
1               5                   10                  15      


Ala Lys Ala Leu Gly Val Lys Ser Ala Phe Leu Lys Asp Asp Asp Val 
            20                  25                  30          


Ile Met Thr Ser Phe Gly Arg Gly Asn Asp Ala Val Val Glu Lys Ile 
        35                  40                  45              


Ile Lys Asn Asn Glu Val Gln Asn Ile Asn Ile Asp Lys Pro Val Tyr 
    50                  55                  60                  


Asp Val Val Gly Val Glu Lys Glu Thr Gly Ile Ile Asn Val Val Gly 
65                  70                  75                  80  


Thr Lys Arg Gly Ile Asn Thr Ile Asn Lys Lys Lys Gln Tyr Ala Asn 
                85                  90                  95      


Thr Gln Val Ser Gln Lys Arg Met Gly Met Asp Leu Ile Gln Arg Lys 
            100                 105                 110         


Asp Lys Leu Glu Lys Val Phe Phe Asn Glu Asn Phe Asn Asp Asn Ile 
        115                 120                 125             


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ser 
    130                 135                 140                 


Val Tyr Val Asn Asn Ile Val Tyr Ala Leu Gly Asn Leu Glu Arg Asp 
145                 150                 155                 160 


Asn Ser Asp Asp Glu Lys Asp Leu Ile Gly Tyr Ala Ser Thr Leu Asn 
                165                 170                 175     


Ser Tyr Glu Asp Phe Ile Asn Lys Asn Leu Val Lys Gln Asn Glu Asn 
            180                 185                 190         


Ile Asp Lys Phe Ile Glu Asn Gly Asn Arg Leu Gly Tyr Phe Gly Asn 
        195                 200                 205             


Val Phe Tyr Lys Asn Lys Asn Glu Leu Lys Asp Lys Lys Asp Ile Phe 
    210                 215                 220                 


Asp Met Leu Cys Leu Leu Gly Ser Leu Arg Gln Phe Cys Phe His Phe 
225                 230                 235                 240 


Lys Gly Ala Lys Phe Glu Gly Val Glu Gln Ile Ser Asn Ser Trp Leu 
                245                 250                 255     


Tyr Asn Leu Ser Gln Leu His Asn Glu Phe Lys Ser Thr Leu Asp Ser 
            260                 265                 270         


Phe Tyr Asn Glu Lys Ile Glu Asp Ile Asn Gly Asn Phe Ile Glu Lys 
        275                 280                 285             


Asn Lys Val Asn Ile Gln Ile Leu Cys Asn Asp Leu Lys Leu Asp Lys 
    290                 295                 300                 


Asn Lys Leu Val Gln Asp Tyr Tyr Asn Phe Leu Ile Ser Lys Asn His 
305                 310                 315                 320 


Lys Asn Met Gly Phe Ser Ile Lys Lys Ile Arg Glu Tyr Ile Leu Asp 
                325                 330                 335     


Ile Asp Tyr Ala Ser Tyr Ile Lys Glu Gln Gly Tyr Asp Ser Val Arg 
            340                 345                 350         


Ser Lys Leu Phe Thr Leu Ile Asp Phe Ile Ile Tyr Asp Leu Tyr Val 
        355                 360                 365             


Asn Lys Glu Lys Asp Arg Ile Asp Asp Ile Val Ser Lys Leu Arg Gly 
    370                 375                 380                 


Ala Ile Tyr Asp Tyr Lys Lys Asp Asp Ile Tyr Lys Ala Glu Ala Asp 
385                 390                 395                 400 


Trp Val Trp Lys Lys Leu Asn Arg Gln Ile Lys Ala Leu Thr Lys Leu 
                405                 410                 415     


Leu Ser Asn Arg Arg Ile Phe Ser Gln Asp Asn Asp Ile Thr Asn Trp 
            420                 425                 430         


Asn Gly Val Glu Phe Glu Lys Ile Gly Glu Gln Lys Leu Glu Asp Asn 
        435                 440                 445             


Ala Asp Tyr Phe Cys Lys Leu Met Tyr Phe Val Thr Leu Phe Leu Asp 
    450                 455                 460                 


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp 
465                 470                 475                 480 


Asn Ile Arg Ser Phe Ile Glu Val Met Glu Glu Met Ser Leu Lys Cys 
                485                 490                 495     


Glu Phe Met Glu Glu Tyr Lys Phe Phe Asn Glu Ser Lys Asp Ile Cys 
            500                 505                 510         


Leu Arg Leu Lys Glu Ile His Ser Phe Ala Arg Met Lys Arg Pro Leu 
        515                 520                 525             


Asp Asn Lys Asn Val Glu Lys Glu Met Tyr Lys Asp Ala Ile Ser Ile 
    530                 535                 540                 


Leu Met Lys Asp Ser Ser Ile Glu Asn Ser Asn Ile Asp Val Ile Phe 
545                 550                 555                 560 


Asn Thr Tyr Ile Tyr Gln Lys Asp Asn Lys Asn Ala Lys Lys Asp Phe 
                565                 570                 575     


Arg Asn Phe Ile Ile Lys Asn Val Ile Lys Ser Asn Arg Phe Ile Tyr 
            580                 585                 590         


Leu Ile Lys Tyr Ser Asn Pro Thr Asn Val Arg Lys Phe Ala Ser Asn 
        595                 600                 605             


Thr Asn Val Ile Lys Phe Val Leu Gly Thr Leu Pro Asp Lys Gln Leu 
    610                 615                 620                 


Glu Arg Tyr Tyr Lys Ser Cys Gly Leu Ser Asp Gly Ile Gly Lys Thr 
625                 630                 635                 640 


Glu Trp Val Arg Glu Leu Ser Glu Ile Ile Thr Gly Ile Asp Tyr Ser 
                645                 650                 655     


Asp Phe Leu Asn Val Lys Gln Arg Ala Lys Ser Lys Glu Glu Lys Glu 
            660                 665                 670         


Asp Lys Ala Lys Lys Gln Ala Ile Val Thr Leu Tyr Leu Thr Ile Leu 
        675                 680                 685             


Tyr Ile Leu Thr Lys Asn Leu Val Asn Val Asn Ser Arg Tyr Val Ile 
    690                 695                 700                 


Ala Val His Cys Ile Glu Arg Asp Ser Glu Leu Tyr Lys Thr Glu Leu 
705                 710                 715                 720 


Tyr Glu Lys Leu Lys Pro Glu Gln Pro Glu Lys Leu Tyr Lys Ile Lys 
                725                 730                 735     


Pro Asp Lys Pro Leu Gln Pro Ala Gln Tyr Phe Leu Phe Thr Lys Tyr 
            740                 745                 750         


Leu Leu Gln Asn Asp Phe Phe Gly Glu Tyr Thr Ser Lys Lys Asn Gln 
        755                 760                 765             


Tyr Ile Gln Lys Asn Met Lys Ile Tyr Ser Lys Ile Asn Lys Asn Phe 
    770                 775                 780                 


Asn Val Phe Val Arg Tyr Arg Asn Asn Ile Ala His Leu Asn Ser Ile 
785                 790                 795                 800 


Lys Asn Ala Thr Lys Tyr Val Asn Asp Ile Gly Thr Phe Thr Ser Tyr 
                805                 810                 815     


Phe Gln Leu Tyr His Tyr Ile Met Gln Cys Asp Leu Lys Asp Trp Val 
            820                 825                 830         


Lys Lys Glu Val Glu Glu Lys Lys Ile Ser Asp Lys Tyr Tyr Asn Tyr 
        835                 840                 845             


Leu Glu Lys Tyr Tyr Lys Asn Asn Asn Ile Tyr Leu Lys Asp Phe Val 
    850                 855                 860                 


Lys Ala Ile Asn Val Pro Phe Ala Tyr Asn Tyr Ser Arg Phe Lys Asn 
865                 870                 875                 880 


Leu Ser Ile Asp Lys Leu Phe Asp Lys Asn Asp Pro Arg Lys Lys Lys 
                885                 890                 895     


Trp Ile Val Ile Phe Asn Phe 
            900             


<210>  215
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  215
gaactacacc cttgttaaat aacatgggtc taaaac                                 36


<210>  216
<211>  951
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  530373_GL0023589

<400>  216

Met Lys Thr Glu Met Lys Asn Gly Glu Val Lys Thr Ser Ala Lys Lys 
1               5                   10                  15      


Glu Asn Cys Ser Ile Ala Lys Ala Asn Gly Leu Lys Ser Thr Phe Lys 
            20                  25                  30          


Leu Ala Glu Asn Thr Tyr Tyr Met Thr Ser Phe Gly Lys Asn Asn Thr 
        35                  40                  45              


Ala Asp Pro Glu Lys Asn Ile Val Arg Met Asn Val Glu Asn Ile Arg 
    50                  55                  60                  


Asn Thr Phe Ser Ala Thr Pro Ile Ser Glu Arg Ile Val Asp Ile Thr 
65                  70                  75                  80  


Gly Glu Thr Lys Lys Thr Ala Gln Val Val Leu Pro Ala Cys Ser Asp 
                85                  90                  95      


Asn Gln Leu His Ala Lys Asp Thr Ile Glu Gln Met Tyr Phe Gly Lys 
            100                 105                 110         


Thr Tyr Thr Asp Asn Ile His Ile Gln Ile Ala Tyr Asn Ile Met Asp 
        115                 120                 125             


Met Lys Lys Ile Phe Gly Val Tyr Ser Asn Asn Ile Ile Tyr Ser Ile 
    130                 135                 140                 


Asn Asn Leu Leu Glu Glu Arg Glu Gly Ser Asp Phe Leu Gly Val Phe 
145                 150                 155                 160 


Tyr Thr Glu Asn Ser Tyr Gln Ala Met Asn Phe Ala Asp Ala Ile Ile 
                165                 170                 175     


Lys Ser Lys Leu Leu Thr Lys Asn Ser Lys Tyr Leu Asn Leu Asp Met 
            180                 185                 190         


Asn Asn Val Trp Phe Asn Lys Glu Val Ser Glu Leu Ser Ser Phe Arg 
        195                 200                 205             


Lys Tyr Val Tyr Ser Arg Ser Tyr Ala Asn Lys Thr Ser Thr Ala Lys 
    210                 215                 220                 


Lys Ile Cys Ile Cys Leu Gln Glu Asp Phe His Phe Phe Asp Tyr Ala 
225                 230                 235                 240 


Thr Val Lys Lys Ala Ala Asp Gln Phe Thr Leu Leu Lys Arg Ile Gln 
                245                 250                 255     


Arg Ser Asn Tyr Phe Phe Asp Met Leu Cys Asp Ser Ala Gly Asn Tyr 
            260                 265                 270         


Gln Cys Lys Asn Ala Gln Ile Leu Leu Ser Ile Leu Gly Asn Leu Arg 
        275                 280                 285             


Gln Glu Ser Phe His Glu Asn Arg Ser Thr Ser Ala Trp Met Phe Asn 
    290                 295                 300                 


Leu Glu Lys Val Leu Thr Pro Glu Arg Lys Lys Leu Leu Thr Ala Leu 
305                 310                 315                 320 


Ile Asp Ser Arg Thr Asn His Ile Asn Asn His Phe Ile Glu Asn Ser 
                325                 330                 335     


Asn Lys Asn Leu Asn Ala Ile Phe Arg Leu Phe Pro Glu Lys Ser Gln 
            340                 345                 350         


Ala Asp Leu Ile Val Glu Tyr Tyr Asp Phe Ser Val Arg Lys Ala Tyr 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Val Lys Leu Leu Arg Glu Met Leu Leu Lys 
    370                 375                 380                 


Thr Gln Gln Glu Leu Ser Pro Leu Asn Asp Lys Ala Tyr Asp Ser Ile 
385                 390                 395                 400 


Arg Ser Lys Leu Tyr Thr Met Phe Asp Phe Val Leu Tyr Lys Leu Tyr 
                405                 410                 415     


Val Asp Asn Glu Glu Gln Ile Asp Gln Phe Val Arg Lys Leu Arg Ala 
            420                 425                 430         


Ser Thr Ser Asn Val Glu Lys Glu Ala Leu Tyr Gln Gln Glu Ser Glu 
        435                 440                 445             


Arg Thr Trp Asn Glu Ile Arg Gly Gln Ile Ile Asp Asn Val Ile Pro 
    450                 455                 460                 


Phe Ile Asp Ser Ile Gln Lys Gln Glu Asn Glu Asp Lys Leu Thr Lys 
465                 470                 475                 480 


Arg Ile Asp Gln Ser Ile Ile Asp Lys Ala Val Pro His Phe Val Asn 
                485                 490                 495     


Ser Arg Asp Leu Ser Tyr Phe Ala Lys Val Val Tyr Val Val Ala Ser 
            500                 505                 510         


Phe Leu Asp Ser Lys Glu Ile Asn Met Phe Phe Asp Ala Leu Ile Asn 
        515                 520                 525             


Glu Leu Glu Asn Ile Ala Ser Phe Asn Asp Val Leu Glu Gln Leu Asp 
    530                 535                 540                 


Met Pro Leu Asp Tyr Gln Glu Lys Tyr Arg Phe Phe Glu Arg Ser Arg 
545                 550                 555                 560 


Glu Glu Ala Ala Gly Leu Arg Phe Ile Lys Ser Ile Ala Lys Met Asn 
                565                 570                 575     


Lys Thr Arg Val Ala Val Lys Asn Asp Thr Lys Thr Val Lys Leu Lys 
            580                 585                 590         


Gln Tyr Cys Asp Ala Gly Ala Val Leu Gly Glu Ile Asn Ala Glu Lys 
        595                 600                 605             


Ile Lys Ala Ala Phe Gly Leu Gly Asp Lys Phe Asn Thr Glu Glu Ala 
    610                 615                 620                 


Arg Val Asp His Thr Phe Arg Asn Phe Ile Ile Asn Asn Val Ile Asn 
625                 630                 635                 640 


Ser Asn Arg Phe Asn Tyr Val Met Arg Phe Met Asn Pro Lys Ser Ala 
                645                 650                 655     


Arg Arg Ile Met Gln Cys Glu Ser Leu Val Ala Phe Ser Leu Lys Asp 
            660                 665                 670         


Ile Pro Asp Thr Gln Ile Glu Arg Tyr Cys Lys Ser Val Asn Ile Pro 
        675                 680                 685             


Phe Asp Ser Ala Asn Pro Asn Tyr Ala His Met Lys Glu Gln Leu Thr 
    690                 695                 700                 


Tyr Lys Leu Leu Gln Val Gln Phe Cys Asn Phe Ser Lys Val Ser Asn 
705                 710                 715                 720 


Ser Ser His Gln Ala Val Glu Lys Glu Arg Leu Lys Ala Leu Val Gly 
                725                 730                 735     


Leu Tyr Leu Ser Val Leu Tyr Arg Ile Val Lys Ser Ile Val Arg Ile 
            740                 745                 750         


Asn Thr Ser Tyr Thr Ile Ala Phe Ala Ala Tyr Glu Arg Asp Cys Val 
        755                 760                 765             


Ile Leu Asn Arg Lys Met Gly Lys Asn Leu Tyr Gly Leu Lys Thr Asp 
    770                 775                 780                 


Pro Met Gly Ile Thr Asn Asp Phe Met His Met Pro Thr Val Ala Pro 
785                 790                 795                 800 


Ser Asn Pro His Asn Asp Phe Ile Asn Glu Thr Lys Leu Ser Lys Arg 
                805                 810                 815     


Val Cys Ala Leu Val Asn Lys Asn Arg Thr Leu Cys Thr Asn Arg Thr 
            820                 825                 830         


Tyr Gln Val Tyr Arg Asn Ile Ile Met His Leu Asn Ala Val Ser Ala 
        835                 840                 845             


Phe Pro Gln Tyr Leu Glu Gly Leu Lys Val Val His Ser Tyr Phe Asp 
    850                 855                 860                 


Leu Tyr His Tyr Thr Val Met Met Leu Leu His Arg Gln Asn Glu Lys 
865                 870                 875                 880 


Glu Lys Lys Arg Asn Glu Lys Glu Lys Lys Gln Asn Glu Lys Glu Asn 
                885                 890                 895     


Asn Met Ile Leu Ser Thr Ala Ala Leu Glu Lys Tyr Asp Met Val Arg 
            900                 905                 910         


Lys Tyr Gln Ser Ala Asn Lys Asp Phe Ile Tyr Ala Ile Asn Ser Pro 
        915                 920                 925             


Leu Ala Tyr Asn Ala Ala Arg Tyr Ile Asn Leu Ser Cys Arg Thr Lys 
    930                 935                 940                 


Phe Glu Glu Gly Phe Gly Lys 
945                 950     


<210>  217
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  217
acttaaatcc ccctgtaaat gcgggggttc taaaac                                 36


<210>  218
<211>  928
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BMZ-11B_GL0037771

<400>  218

Met Ser Lys Asp Lys Lys Thr Lys Ala Lys Arg Met Gly Val Lys Ala 
1               5                   10                  15      


Leu Leu Ala His Gly Glu Asp Lys Leu Thr Met Thr Thr Phe Gly Lys 
            20                  25                  30          


Gly Asn Arg Ser Lys Ile Glu Phe Thr Glu Gly Tyr His Gly Arg Ala 
        35                  40                  45              


Leu Glu Thr Pro Lys His Phe Gly Lys Arg Gly Phe Glu Val Arg Lys 
    50                  55                  60                  


Ile Asp Glu Asn Val Asp Leu Tyr Gly Asp Leu Glu Glu Gly Lys Thr 
65                  70                  75                  80  


Ile Glu Ala Leu Leu Ile Asn Pro Ser Glu Lys Val Gly Glu Asp Tyr 
                85                  90                  95      


Leu Lys Leu Lys Gly Thr Leu Glu Lys Arg Phe Phe Gly Arg Glu Phe 
            100                 105                 110         


Pro His Asp Asn Ile Arg Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile 
        115                 120                 125             


Tyr Lys Ile Leu Gly Met Asn Val Ala Asp Ile Leu Tyr Ala Leu Gly 
    130                 135                 140                 


Asn Met Gln Asp Thr Glu Leu Asp Ile Asp Met Phe Gly Gln Ser Leu 
145                 150                 155                 160 


Asn Asn Pro Glu Lys Ala Lys Asp Val Val Gln Arg Met Lys Pro Tyr 
                165                 170                 175     


Met Gly Phe Phe Gly Gly Ile Phe Arg Thr Gln Lys Lys Glu Asp Arg 
            180                 185                 190         


Lys Lys Asp Ser Asn Leu Ser Glu Glu Glu Lys Glu Glu Lys Lys Lys 
        195                 200                 205             


Lys Gln Glu Glu Leu Leu Gln Lys Asp Leu Gln His Asn Met Asp Val 
    210                 215                 220                 


Ala Arg Cys Ile Ser Ala Leu Arg His Ala Thr Ala His Asn Lys Pro 
225                 230                 235                 240 


Ala Thr Ala His Asp Lys Gln Asp Glu Tyr Pro Trp Phe Lys Ser Ser 
                245                 250                 255     


Asp Ile Tyr Glu Thr Lys Ile Phe Lys Ala Gly Met Trp Ser Val Ile 
            260                 265                 270         


Glu Ala Asp Tyr Lys Lys Lys Ile Gln Asp Val Asn Lys Gln Phe Phe 
        275                 280                 285             


Ser Lys Asn Lys Val Asn Leu Ala Ile Leu Phe Asp Leu Leu Asp Val 
    290                 295                 300                 


Arg Asp Val Lys Gln Lys Lys Arg Ile Ser Asp Glu Phe Tyr Arg Phe 
305                 310                 315                 320 


Thr Ile Arg Lys Asp Gly Lys Asn Leu Gly Met Asn Leu Val Lys Ile 
                325                 330                 335     


Arg Glu Ile Ile Ile Asp Arg Tyr Ala Ser Gly Leu Arg Asp Lys Lys 
            340                 345                 350         


His Asp Pro His Arg Gln Lys Ile Asn Val Ile Ala Asp Phe Leu Ile 
        355                 360                 365             


Phe Arg Ala Leu Ser Gln Asn Gln Gly Ile Ile Asp Lys Thr Val Ser 
    370                 375                 380                 


Ser Leu Arg Leu Thr Lys Asp Glu Glu Glu Lys Asp His Val Tyr Gln 
385                 390                 395                 400 


Asn Ala Ala Glu Leu Val Trp Gly Met Val Ser Asn Cys Leu Thr Pro 
                405                 410                 415     


Tyr Phe Asn Asp Pro Lys Asn Lys Tyr Ile Leu Lys Tyr Lys Asp Ala 
            420                 425                 430         


Lys Thr Pro Gly Asp Phe Glu Asp Trp Ile Thr Ser Lys Ile Ser Glu 
        435                 440                 445             


Asp Asp Gly Glu Pro Phe Val Lys Val Leu Ser Phe Leu Cys Asn Phe 
    450                 455                 460                 


Leu Glu Gly Lys Glu Ile Asn Glu Leu Leu Thr Ala Tyr Ile His Lys 
465                 470                 475                 480 


Phe Glu Cys Ile Gln Asp Phe Leu Asn Val Ile Ser Ser Leu Gly Glu 
                485                 490                 495     


Asn Val Gln Phe Gln Pro Arg Phe Ala Leu Phe Asn Asn Ala Ser Phe 
            500                 505                 510         


Ala Gln Asn Val Ala Val Gln Leu Arg Ile Leu Ala Ser Ile Gly Lys 
        515                 520                 525             


Met Lys Pro Asp Leu Thr Glu Ala Lys Arg Pro Leu Tyr Lys Ala Ala 
    530                 535                 540                 


Ile Arg Met Leu Cys Pro Pro Glu Lys Trp Glu Lys Tyr Thr Ser Asp 
545                 550                 555                 560 


Glu Trp Leu Glu Lys Asn Met Leu Leu Asn Ser Glu Asp Arg Lys Asn 
                565                 570                 575     


Asp Lys Lys Lys Lys Gln Val Asn Pro Phe Arg Asn Phe Ile Ala Gly 
            580                 585                 590         


Asn Val Ile Glu Ser Arg Arg Phe Met Tyr Leu Val Arg Tyr Ser Lys 
        595                 600                 605             


Pro Lys Ala Val Arg Ala Ile Met Gln Asn Arg Ser Ile Val Asn Tyr 
    610                 615                 620                 


Val Leu His Arg Leu Pro Ser Glu Gln Ile Lys Thr Tyr Ser Arg Val 
625                 630                 635                 640 


Phe Pro Glu Asp Phe Ser Asp Thr Glu Ala Glu Ile Asp Phe Leu Val 
                645                 650                 655     


Asn Lys Leu Ser Glu Phe Ser Phe Glu Thr Phe Ile Ser Asn Gln Gln 
            660                 665                 670         


Thr Ile Leu Asn Asn Ser Lys Arg Gly Phe Ser Pro Asn Arg Arg Glu 
        675                 680                 685             


Thr Ala Glu Glu Ile Glu Arg Leu Lys Ala Ile Thr Gly Leu Tyr Leu 
    690                 695                 700                 


Ser Val Ala Tyr Ile Ala Ile Lys Asn Ile Val Lys Ala Asn Ala Arg 
705                 710                 715                 720 


Tyr Tyr Ile Ala Phe Ala Val Phe Glu Arg Asp Lys Glu Leu Val Lys 
                725                 730                 735     


Ala Lys Asp Ala Arg Ile Gln Thr Thr Ile Pro Asn Thr Lys Phe Thr 
            740                 745                 750         


Asn Tyr Phe Cys Leu Thr Gln Tyr Tyr Leu Asp Arg Asp Glu Glu Lys 
        755                 760                 765             


Lys Phe Pro Gly Asp Pro Arg Asp Lys Glu Ala Phe Phe Glu His Leu 
    770                 775                 780                 


Arg Lys Thr Lys Arg His Phe Ser Lys Gln Trp Arg Glu Trp Leu Asn 
785                 790                 795                 800 


Glu Lys Ile Ala Asp Ala Lys Ser Ser Gln Ala Thr Gly Leu Leu Leu 
                805                 810                 815     


Arg Glu Ala Arg Asn Asp Val Glu His Leu Asn Val Leu Arg Ala Ile 
            820                 825                 830         


Pro Asp Tyr Ile Gln Asp Phe Arg His Gly Glu Lys Gly Glu Thr Ala 
        835                 840                 845             


Met Asn Ser Tyr Phe Glu Leu Tyr His Tyr Leu Met Gln Arg Leu Met 
    850                 855                 860                 


Leu Lys Asn Thr Glu Leu Asp Leu Ser His Trp Ser Gly Trp Ile Met 
865                 870                 875                 880 


Arg Ser Gly Arg Pro Asp Arg Asp Leu Ile Gln Ile Ala Phe Val Ser 
                885                 890                 895     


Leu Ala Tyr Asn Leu Pro Arg Tyr Arg Asn Leu Thr Lys Glu His His 
            900                 905                 910         


Phe Asp Asp Thr Val Leu Gln Lys Ile Arg Glu Lys Glu Ser Leu Asp 
        915                 920                 925             


<210>  219
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  219
ggtcaacagt gtggggaatt acccgcactc tacaac                                 36


<210>  220
<211>  940
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BMZ-11B_GL0037915

<400>  220

Met Ala Glu His Ser Lys Lys Thr Ala Ala Lys Arg Val Gly Ile Lys 
1               5                   10                  15      


Ser Val Ile Ala His Asp Gly Gly Lys Leu Ala Val Thr Thr Phe Gly 
            20                  25                  30          


Lys Lys Ser Ala Ala Lys Leu Ala Tyr Arg Asp Gly Asp Gln Thr Pro 
        35                  40                  45              


Phe Asp Glu Glu Lys Lys Ser Glu Leu Gly Gly Phe Asn Val Thr Gly 
    50                  55                  60                  


Val Asp Glu Asn Thr Val Asp Ala Glu Arg Gly Ile Pro Gly Glu Gly 
65                  70                  75                  80  


Leu Ile Glu Ala Ser Val Ala Asn Pro Val Asn Asp Leu Ile Asp Glu 
                85                  90                  95      


Ser Arg Lys Glu Tyr Gly Gln Asp Tyr Leu Met Leu Lys Asp Gln Leu 
            100                 105                 110         


Glu Lys Val Phe Phe Gly Gln Thr Phe Pro Gly Asp Asn Leu Arg Ile 
        115                 120                 125             


Gln Ile Ile Tyr Asn Ile Leu Asp Met Gln Lys Ala Phe Gly Leu Tyr 
    130                 135                 140                 


Val Asn Asp Val Leu Tyr Ala Val Asn Asn Leu Gln Asn Thr Gly Arg 
145                 150                 155                 160 


Leu Leu Thr Asp Asp Asp Trp Thr Ser Asp Val Ile Gly Leu Ala Leu 
                165                 170                 175     


Gly Lys Gly Arg Gly Lys Glu Ile Ile Glu Ser Met Ser Asp Ala Leu 
            180                 185                 190         


Gly Phe Phe Gly Ser Ala Phe Lys Pro Ile Pro Lys Lys Pro Gly Asp 
        195                 200                 205             


Lys Thr Ser Gly Lys Tyr Ala Gly Gly Lys Leu Lys Glu Arg Asp Ala 
    210                 215                 220                 


Ala Ile Ala Glu Asp Val Ala Val Leu Arg Val Leu Cys Gly Leu Arg 
225                 230                 235                 240 


Gln Ile Ser Ala His Phe Arg Ser Glu Lys Lys Gly Glu Ser Leu Trp 
                245                 250                 255     


Ala Ser Asp Leu Gly Val Glu Lys Tyr Phe Lys Asn Glu Met Ser Val 
            260                 265                 270         


Val Asp Ala Asn Tyr Lys Ala Arg Ala Lys Lys Ile Asp Ala Asn Phe 
        275                 280                 285             


Met Ala Thr Ser Arg Ala Asn Leu Val Leu Leu Phe Arg Ile Leu Asn 
    290                 295                 300                 


Ala Lys Thr Lys Glu Glu Lys Glu Lys Ile Ala Val Asp Tyr Tyr Lys 
305                 310                 315                 320 


Phe Ala Ile Arg Lys Glu Gly Lys Asn Leu Gly Val Asn Leu Lys Lys 
                325                 330                 335     


Ala Arg Glu Ile Leu Leu Asp Lys His Tyr Pro Asp Ala Lys Asn Lys 
            340                 345                 350         


Gln Phe Asp Ser Tyr Arg Gly Lys Leu Tyr Thr Ile Thr Asp Phe Ile 
        355                 360                 365             


Ile Tyr Arg Met Ala Ala Glu Asp Gly Ala Phe Leu Glu Glu Ser Val 
    370                 375                 380                 


Gln Lys Leu Arg Ser Thr Pro Ser Glu Glu Glu Lys Glu Lys Val Tyr 
385                 390                 395                 400 


Asp Val Leu Ala Glu Thr Ile Trp Asn Ala Thr Lys Asp Asp Val Lys 
                405                 410                 415     


Lys Val Phe Asp Ile Arg Gln Gln Asp Ile Lys Asn Ala Ala Ala Gln 
            420                 425                 430         


Ser Leu Asp Asp Val Asn Leu Asp Ser Val Thr Val Glu Lys Glu Lys 
        435                 440                 445             


Glu Phe Pro Val Val Lys Leu Leu Ala Phe Leu Cys Asn Phe Leu Asp 
    450                 455                 460                 


Gly Lys Glu Ile Asn Glu Leu Leu Ser Thr Phe Val Asn Arg Leu Glu 
465                 470                 475                 480 


Asn Val Gln Ala Leu Ile Asp Leu Ala Lys Asn Leu Gly Glu Thr Val 
                485                 490                 495     


Asn Phe Ser Lys Asn Tyr Ala Val Phe Asn Asp Cys Gly Ser Gly Ala 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Arg Leu Arg Leu Leu Ala Ser Ile Gly Lys 
        515                 520                 525             


Met Asp Ala Gly Leu Asp Ser Leu Lys Pro Leu Phe Ile Arg Phe Ala 
    530                 535                 540                 


Ile Gln Ile Leu Gly Gly Ala Arg Ile Ser Asp Glu Asp Val Asp Ala 
545                 550                 555                 560 


Tyr Ile Lys Glu Asn Ile Leu Val Arg Lys Asp Asp Pro Glu Lys Lys 
                565                 570                 575     


Arg Ser Asn Thr Phe Arg Asn Phe Ile Thr Asn Asn Val Ile Lys Ser 
            580                 585                 590         


Arg Arg Phe Val Tyr Leu Val Arg Tyr Thr Lys Ala Asp Ala Val Arg 
        595                 600                 605             


Ala Val Met Lys Asn Gly Lys Ile Val Arg Tyr Val Leu Ala Arg Ile 
    610                 615                 620                 


Pro Glu Thr Gln Val Asp Ser Tyr Tyr Lys Ser Val Val Asp Ser Ser 
625                 630                 635                 640 


Asp Ala Gly Asn Gly Lys Pro Ile Lys Glu Lys Ile Lys Ala Leu Ala 
                645                 650                 655     


Glu Lys Leu Gly Glu Phe Ser Phe Asp Leu Ile Ala Glu Asn Arg Asp 
            660                 665                 670         


Gly Ile Ile Asp Asn Ala Lys Leu Asp Glu Glu Lys Lys Asn Val Glu 
        675                 680                 685             


Ile Glu Arg Leu Lys Ala Val Thr Gly Leu Tyr Leu Thr Val Ala Phe 
    690                 695                 700                 


Ile Ala Ile Lys Asn Leu Val Lys Ala Asn Ala Arg Tyr Tyr Ile Ala 
705                 710                 715                 720 


Tyr Ser Ala Phe Glu Arg Asp Ser Glu Leu Leu Lys Glu Lys Leu Gly 
                725                 730                 735     


Glu Glu Glu Phe Tyr Lys Leu Cys Ile Glu Phe Lys Asn Lys Lys Gly 
            740                 745                 750         


Glu Thr Gly Tyr Asn Asn Ala Phe Ala Leu Leu Lys Tyr Tyr Ile Asp 
        755                 760                 765             


Arg Asp Glu Asp Ile Trp Arg Lys Glu Glu Ala Thr His Arg Gly Arg 
    770                 775                 780                 


Asp Glu Asn Gly Lys Leu Asp Tyr Asp Pro Asp Pro Arg Arg Lys His 
785                 790                 795                 800 


Tyr Pro Lys Arg Arg Trp Leu Asn Ile Leu Lys Asp Asn Leu Ala Glu 
                805                 810                 815     


Met Glu Arg Ile Asp Pro Thr Gly Met Leu Ala Ala Gln Met Arg Asn 
            820                 825                 830         


Asp Ala Met His Leu Asn Ala Met Phe Lys Ile Ala Lys Phe Val Gly 
        835                 840                 845             


Asp Phe Arg Lys Gly Ser Ser His Glu Met Arg Ser Tyr Phe Glu Leu 
    850                 855                 860                 


Phe His Phe Leu Glu Gln Lys Thr Leu Leu Asp Ser Lys Glu Asp Phe 
865                 870                 875                 880 


Val Gln Gly Met Arg Glu Ser Tyr Gly Asp Arg Ile Arg Val Glu Pro 
                885                 890                 895     


Cys Val Asp Leu Ile Lys Tyr Leu Tyr Ile Thr Leu Gly Tyr Ser Leu 
            900                 905                 910         


Pro Arg Tyr Lys Thr Met Thr Val Ser Gly Leu Phe Asp Pro Asp Ser 
        915                 920                 925             


Glu Asp Ala Lys Glu Arg Ala Lys Gly Lys Arg Ala 
    930                 935                 940 


<210>  221
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  221
ggtcaacagt gtggggaatt acccgcactc tacaac                                 36


<210>  222
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BMZ-11B_GL0069617

<400>  222

Met Pro His Asn Lys Lys Ser Thr Ile Lys Arg Ile Gly Val Lys Ser 
1               5                   10                  15      


Ala Phe Ser His Gly Asn Ser Arg Leu Thr Ile Thr Gln Phe Gly Arg 
            20                  25                  30          


Gly Asn Thr Ala Asp Ile Ala Val Glu Thr Asp Ser Arg Gly Arg Ser 
        35                  40                  45              


Leu Ser Leu Pro His Arg Val Glu Lys Ser Phe Thr Val Asn Lys Ile 
    50                  55                  60                  


Asp Asp Glu Ile Asp Val Gln Arg Ser Ser Leu Leu Gly Thr Leu Leu 
65                  70                  75                  80  


Asn Pro Ala Glu Asn Asp Pro Val Asp Tyr Leu Gly Leu Lys Ser Thr 
                85                  90                  95      


Leu Glu Lys Glu Phe Phe Gly Gln Glu Phe Pro Asn Asp Ser Ile Arg 
            100                 105                 110         


Ile Gln Ile Ile His Asn Ile Leu Asp Ile Gln Lys Ile Leu Gly Ile 
        115                 120                 125             


Tyr Ile Asn Asp Val Leu Tyr Ser Ile Ala Asn Leu Gln Asn Val Glu 
    130                 135                 140                 


Thr Val Glu Asp Cys Leu Gly Gln Ser Leu Ser Lys Gly Gln Asp Glu 
145                 150                 155                 160 


Lys Leu Lys Lys Ile Leu Asn Ser Ile Thr Pro Tyr Leu Gly Phe Leu 
                165                 170                 175     


Gly Ala Gly Phe Lys Gln Ser Glu Arg Pro Lys His Gln Lys Asn Ser 
            180                 185                 190         


Arg Pro Asp Pro Arg Gln Lys Ile Glu Asp Pro Asn Trp Ala Tyr Asn 
        195                 200                 205             


Lys Ser Ala Leu Arg Ile Leu Ser Thr Leu Arg Asn Lys Leu Ala His 
    210                 215                 220                 


Phe Glu Asp Ser Ser Ile Leu Phe Cys Asp Asn Leu Lys Gly Gln Phe 
225                 230                 235                 240 


Leu Gly Ser Asn Gly Asn Trp Ile Thr Ile Glu Thr His Tyr Asp Glu 
                245                 250                 255     


Met Ile Thr Arg Ile Asn Glu Ser Phe Phe Asn Asn Ser Arg Met Asn 
            260                 265                 270         


Leu Lys Ile Leu Tyr Leu Val Leu Asn Ala Ala Thr Leu Glu Asp Lys 
        275                 280                 285             


Lys Lys Ile Thr Glu Glu Tyr Tyr Arg Phe Ser Ile Leu Lys Glu Gly 
    290                 295                 300                 


Lys Asn Leu Gly Val Asn Met Arg Lys Leu Arg Glu Met Met Val Asp 
305                 310                 315                 320 


Met Phe Tyr Ser Glu Ile Lys Asp Lys Gln Tyr Asp Ser Tyr Arg Gln 
                325                 330                 335     


Lys Ile Tyr Thr Ile Leu Asp Phe Leu Leu Phe Arg Glu Ile Lys Asp 
            340                 345                 350         


Ser Glu Glu Leu Glu Thr Met Val Ala Asp Leu Arg Glu Ser Glu Ser 
        355                 360                 365             


Asp Glu Lys Lys Glu Glu Leu Tyr His Asp Tyr Ala Glu Leu Phe Trp 
    370                 375                 380                 


Asp Gly Val Lys Asp Leu Ile Val Pro Phe Phe Ala Ala Phe Asp Gly 
385                 390                 395                 400 


Asp Phe Thr Val Phe Thr Thr Glu Lys Val Pro Ala Asp Thr Ser Lys 
                405                 410                 415     


Glu Pro Phe Leu Ser Ser Ala Asn Thr Glu Pro Leu Val Lys Leu Leu 
            420                 425                 430         


Ala Phe Leu Cys Asn Phe Trp Asp Gly Lys Glu Val Asn Glu Val Leu 
        435                 440                 445             


Ser Ala Tyr Ile His Lys Phe Glu Ser Ile Gln Ala Phe Ile Asp Val 
    450                 455                 460                 


Leu Glu Ser Lys Glu Leu Asn Glu Lys Val Val Phe Ser Ala Lys Lys 
465                 470                 475                 480 


Gly Arg Asn Phe Ser Ala Phe Asn Glu His Gly Phe Ala Gly Arg Val 
                485                 490                 495     


Ala Asp Gln Leu Arg Val Leu Ala Ser Ile Gly Lys Met Lys Pro Asp 
            500                 505                 510         


Leu Glu Gly Ala Lys Arg Ala Leu Phe Arg Asp Ala Val Glu Thr Leu 
        515                 520                 525             


Gly Ile Val Glu Asn Ser Asn Trp Leu Asn Glu Asp Gly Thr Ile Ser 
    530                 535                 540                 


Asn Asp Trp Leu Glu Thr Tyr Val Leu Pro Gly Asp Lys Val Thr Glu 
545                 550                 555                 560 


Glu Glu Lys Arg Ala Ile Lys Pro Phe Arg Asn Phe Ile Ala Asn Asn 
                565                 570                 575     


Val Ile Glu Ser Arg Arg Phe Met Tyr Leu Ala Arg Tyr Ala Lys Pro 
            580                 585                 590         


Lys Ser Val Arg Glu Leu Met Lys His Glu Glu Ile Ile Arg Tyr Val 
        595                 600                 605             


Leu Thr Arg Leu Pro Glu Lys Gln Ile Asp Thr Tyr Phe Ser Asn Ile 
    610                 615                 620                 


Ser Glu Gly Asp Glu Ser Glu Ile Ser Arg Lys Ile Asp Thr Leu Thr 
625                 630                 635                 640 


Lys Ala Leu Thr Gly Phe Ser Phe Asn Ser Leu Phe Ile Asn Arg Asp 
                645                 650                 655     


Lys Ile Val Glu Asn Thr Lys Leu Asp Thr Ser Asn Lys Asn Val Lys 
            660                 665                 670         


Ile Glu Arg Leu Lys Ala Leu Thr Gly Leu Tyr Leu Thr Val Ala Phe 
        675                 680                 685             


Val Ala Val Lys Asn Leu Val Lys Ala Asn Ala Arg Tyr Phe Ile Ala 
    690                 695                 700                 


Phe Ser Ala Phe Glu Arg Asp Tyr Gly Phe Met Lys Ser His Asp Pro 
705                 710                 715                 720 


Asp Val Ala Gln Ser Cys Leu Ala Tyr Glu Glu Ile Met Asp Gly Lys 
                725                 730                 735     


Ser Lys Thr Lys Tyr Asn Glu Ile Tyr Ala Leu Thr Glu Tyr Tyr Leu 
            740                 745                 750         


Lys Lys Glu Glu Glu Asn Asp Tyr His Pro Glu Pro Gly Gln Pro Phe 
        755                 760                 765             


Asp Lys Glu Ala Cys Arg Lys His Leu Asp Ser Ile Arg Arg His Phe 
    770                 775                 780                 


Thr Lys Lys Trp Arg Asp Ile Phe Arg Lys Glu Ile Asp Glu Ala Val 
785                 790                 795                 800 


Lys Ile His Phe Thr Gly Tyr Leu Gly Val Trp Ala Arg Asn Gln Ser 
                805                 810                 815     


Ala His Leu Asn Val Leu Thr Gln Ala Leu Pro Gln Phe Ile Gly Gln 
            820                 825                 830         


Phe Ala Arg Asn Ser Lys Thr Gly Lys Thr Ala Arg Met Thr Ser Tyr 
        835                 840                 845             


Phe Gln Leu Tyr His Tyr Leu Leu Gln Arg Leu Leu Cys Glu Asp Leu 
    850                 855                 860                 


Asn Phe Asp Val Pro Glu Glu Trp Lys Asn Lys Ile Gln Glu Thr Gly 
865                 870                 875                 880 


Leu Pro Cys Asn Asp Leu Ile His Ile Cys Phe Val Pro Leu Gly Tyr 
                885                 890                 895     


Asn Leu Pro Arg Tyr Lys Asn Leu Thr Ile Glu Cys Leu Phe Asp Glu 
            900                 905                 910         


Asp Ser Val Ser Ala Lys Glu Gly Lys Lys Ala 
        915                 920             


<210>  223
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  223
atacagcagc cctacagatt cgtagggttc tgtgac                                 36


<210>  224
<211>  993
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DLF014_GL0011914

<400>  224

Met Ala Lys Lys Lys Asn Ala Lys Gln Arg Arg Glu Glu Glu Lys Asn 
1               5                   10                  15      


Arg Leu Lys Ala Lys Ile Glu Lys Phe Lys Ile Lys Tyr Ala Glu Gln 
            20                  25                  30          


Glu Thr Val Asp Lys Ile Thr Glu Glu Ile Ala Gln Ser Asp Lys Ile 
        35                  40                  45              


Met Arg Thr Glu Ser Ile Leu Val Gln His Thr Lys Lys Ser Leu Ala 
    50                  55                  60                  


Lys Ala Ser Gly Val Lys Ser Val Phe Ile Lys Asp Asp Glu Val Ile 
65                  70                  75                  80  


Met Thr Ser Phe Gly Arg Gly Asn Asp Ala Val Val Glu Lys Ile Ile 
                85                  90                  95      


Lys Asp Asn Asn Val Asp Glu Lys Asn Thr Lys Pro Ala Tyr Glu Ile 
            100                 105                 110         


Val Asp Ile Glu Lys Asn Gly Asp Leu Ile Lys Val Gln Ser Arg Arg 
        115                 120                 125             


Cys Lys Asn Ile Glu Ser Ala Asn Thr Glu Leu Pro Pro Glu Lys Ile 
    130                 135                 140                 


Gly Met Asp Leu Ile Arg Cys Lys Asp Lys Leu Glu Glu Ile Tyr Phe 
145                 150                 155                 160 


Gly Arg Thr Phe Asn Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ser Val Tyr Ile Asn Asn Ala Val Tyr 
            180                 185                 190         


Ala Leu Gly Asn Leu Glu Arg Lys Glu Asn Asp Lys Glu Lys Asp Leu 
        195                 200                 205             


Val Gly Tyr Leu Ser Ala Arg Ala Gly Tyr Asn Lys Val Ile Asn Lys 
    210                 215                 220                 


Ala Ile Asn Asp Glu Lys Ile Lys Asp Arg Ile Glu Asp Leu Lys Glu 
225                 230                 235                 240 


Phe Ile Glu Asn Gly Asn Arg Leu Gly Tyr Phe Gly Asp Ile Phe Phe 
                245                 250                 255     


Lys Lys Glu Glu Val Ser Lys Asn Gly Lys Lys Pro Lys Lys Val Glu 
            260                 265                 270         


Val Leu Lys Ser Glu Lys Glu Ile Phe Asp Ile Leu Ala Leu Leu Gly 
        275                 280                 285             


Ser Leu Arg Gln Phe Cys Phe His Tyr Asp Glu Ala Val Phe Glu Asn 
    290                 295                 300                 


Glu Asp Gly Val Ile Asp Lys Glu Tyr Asn Asp Asn Ser Trp Leu Tyr 
305                 310                 315                 320 


Asn Leu Glu Lys Leu Glu Pro Glu Phe Lys Asp Thr Leu Asp Tyr Phe 
                325                 330                 335     


Tyr Asn Arg Lys Ile Asn Asp Ile Asn Lys Gly Phe Ile Lys Thr Asn 
            340                 345                 350         


Gln Ile Asn Leu His Ile Ile Cys Asp Glu Leu Gly Leu Asn Trp Asp 
        355                 360                 365             


Lys Glu Gln Val Val Gly Asp Tyr Tyr Asp Phe Leu Ile Ala Lys Lys 
    370                 375                 380                 


Tyr Lys Asn Ile Gly Phe Ser Ile Lys Lys Ile Arg Glu His Met Phe 
385                 390                 395                 400 


Asp Ile Tyr Glu Ala Phe Asp Ile Lys Asp Lys Arg Phe Asp Ser Val 
                405                 410                 415     


Arg Ser Ile Met Tyr Lys Ile Ile Asp Phe Val Ile Tyr Tyr Ser Phe 
            420                 425                 430         


Ile His Tyr Lys Gln Asp Glu Val Asp Glu Ile Val Asn Tyr Leu Arg 
        435                 440                 445             


Ser Thr Leu Ser Glu Glu Gln Lys Lys Glu Lys Tyr Ile Lys Leu Ala 
    450                 455                 460                 


Gly Asn Ile Trp Ala Glu Tyr Lys Thr Gln Phe Asn Lys Leu Lys Asp 
465                 470                 475                 480 


Ile Leu Leu Ala Asn Ile Lys Glu Phe Ser Asp Ala Lys Glu Asp Asp 
                485                 490                 495     


Val Tyr Tyr Glu Glu Phe Lys Asn Phe Lys Phe Asn Glu Val Gly Lys 
            500                 505                 510         


Glu Lys Leu Gly Glu Asn Ala Glu Tyr Phe Cys Lys Leu Met Tyr Leu 
        515                 520                 525             


Leu Thr Leu Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr 
    530                 535                 540                 


Leu Ile Asn Lys Phe Asp Asn Ile Arg Ser Phe Val Glu Leu Met Lys 
545                 550                 555                 560 


Glu Glu Asn Ile Glu Cys Ile Phe Asp Lys Lys Phe Ala Phe Phe Asp 
                565                 570                 575     


Glu Ser Lys Asn Val Cys Ser Thr Leu Arg Glu Ile Asn Ser Phe Ala 
            580                 585                 590         


Arg Met Gln Lys Pro Leu Asn Asn Val Ser Val Lys Arg Glu Met Tyr 
        595                 600                 605             


Lys Asp Ala Ile Lys Ile Leu Leu Lys Asp Thr Arg Ala Glu Glu Gln 
    610                 615                 620                 


Asn Ile Asp Arg Ile Leu Asn Glu Tyr Ile Pro Ser Lys Glu Asp Lys 
625                 630                 635                 640 


Gly Ile Lys Lys Asp Phe Arg Asn Phe Ile Ile Lys Asn Ile Ile Lys 
                645                 650                 655     


Ser Asn Arg Phe Met Tyr Leu Val Lys Tyr Ser Asn Pro Thr Asp Val 
            660                 665                 670         


Arg Asn Leu Ala Ser Asn Arg Asn Val Val Lys Phe Val Leu Asn Ala 
        675                 680                 685             


Ile Pro Asp Thr Gln Ile Asp Arg Tyr Tyr Lys Ser Cys Ile Gln His 
    690                 695                 700                 


Tyr Ser Asn Glu Val Asp Lys Glu Thr Gln Ile Gln Glu Leu Thr Asp 
705                 710                 715                 720 


Ile Ile Thr Gly Ile Asp Tyr Leu Asp Phe Leu Asp Val Arg Gln Ser 
                725                 730                 735     


Tyr Arg Asn Glu Asp Lys Ser Lys Lys Gln Ala Val Val Thr Leu Tyr 
            740                 745                 750         


Leu Thr Ile Leu Tyr Ile Leu Thr Lys Asn Leu Val Asn Val Asn Ser 
        755                 760                 765             


Arg Tyr Val Ile Ala Leu His Cys Leu Glu Arg Asp Ser Lys Leu Tyr 
    770                 775                 780                 


Gly Tyr Thr Lys Leu Ser Lys Lys Asn Asn Lys Lys Leu Glu Lys Ile 
785                 790                 795                 800 


Lys Pro Pro Lys Tyr His Glu Leu Thr Lys Tyr Phe Ile Asp Asn Arg 
                805                 810                 815     


Tyr Phe Asp Arg Lys Lys Lys Asn Lys Lys Tyr Gly Glu Tyr Thr Ser 
            820                 825                 830         


Lys Lys Ile Ser Thr Tyr Ile Glu Thr Asn Met Lys Asn Phe Ile Gly 
        835                 840                 845             


Cys Glu Gln Phe Arg Thr Pro Glu Arg Tyr Arg Asp Thr Gln Ile Asp 
    850                 855                 860                 


Met Phe Val Lys Tyr Arg Asn Ser Ile Ala His Leu Asn Ala Val Arg 
865                 870                 875                 880 


Lys Ala Ser Lys Tyr Ile Asn Asp Ile Arg Gly Phe Asp Thr Tyr Phe 
                885                 890                 895     


Glu Leu Tyr His Tyr Ile Met Gln Arg Asp Leu Lys Asp Ile Leu Glu 
            900                 905                 910         


Lys Ile Ala Glu Gly Ala Ala Lys Glu Thr Glu Glu Gly Gln Lys Gln 
        915                 920                 925             


Asp Glu Leu Leu Lys Thr Tyr Phe Asp Asn Leu Asp Lys Tyr Gly Thr 
    930                 935                 940                 


Tyr Val Lys Asp Phe Val Lys Ala Leu Asn Ile Pro Phe Ala Tyr Asn 
945                 950                 955                 960 


Tyr Pro Arg Tyr Lys Asn Leu Ser Ile Asp Glu Leu Phe Asp Lys Asn 
                965                 970                 975     


Asn Thr Arg Lys Thr Ile Lys Ile Gln Asp Lys Lys Leu Glu Glu Arg 
            980                 985                 990         


Thr 
    


<210>  225
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  225
gaactactac ctcacagatt tgtggggttc agaaac                                 36


<210>  226
<211>  924
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EYZ-362B_GL0088915

<400>  226

Met Lys Lys Lys Leu Asn Ile Arg Glu Gln Arg Glu Ala Lys Lys Ala 
1               5                   10                  15      


Ala Ala Lys Gln Ile Tyr Ala Ala Lys Ala Ser Ala Ala Gln Lys Lys 
            20                  25                  30          


Ala Asp Glu Thr Val Val Ala Ala Gln Pro Ala Gly Asp Thr Ala Asn 
        35                  40                  45              


Ser Lys Pro Ile Lys Ser Arg Asn Lys Ala Ala Gly Leu Lys Ser Thr 
    50                  55                  60                  


Phe Val Val Gly Asp Ser Leu Tyr Met Thr Ser Phe Gly Lys Gly Asn 
65                  70                  75                  80  


Leu Ser Val Pro Glu Tyr Arg Val Asp Thr Gly Asp Ala Tyr Arg Val 
                85                  90                  95      


Asp Pro Ile Ser Glu His Ser Glu Leu His Val Leu Gly Ala Asp Asp 
            100                 105                 110         


Leu Ala Val Ser Phe Ser Gly Thr Arg Arg Met Lys Asp Val Ser Glu 
        115                 120                 125             


Leu Lys Ala Asp Asn Pro Leu His Ser Gly Lys Asn Asn Leu Val Pro 
    130                 135                 140                 


Lys Asn Gly Thr Asp Ile Leu Gly Leu Lys Gly Ile Leu Glu Gln Arg 
145                 150                 155                 160 


Tyr Tyr Gly Arg Asn Phe Asp Asp Asn Val His Ile Gln Ile Ile Tyr 
                165                 170                 175     


Asn Ile Leu Asp Ile Glu Lys Asn Leu Ala Ile Tyr Val Thr Asn Val 
            180                 185                 190         


Val Ala Ala Leu Asp His Met Cys Asp Glu Thr Leu Asp Thr Glu His 
        195                 200                 205             


Glu Asp Phe Ile Gly Tyr Met Asn Thr Met Asn Ser Phe Asp Val Phe 
    210                 215                 220                 


Met His Pro Ser Gln Ser Ser Arg Ala Asp Ile Tyr Lys Lys Ile Asn 
225                 230                 235                 240 


Asp Ser Arg Arg Arg Phe Glu Asn Leu Leu Arg Thr Lys Arg Leu Gly 
                245                 250                 255     


Tyr Phe Gly Phe Ala Tyr Asn Pro Lys Asp Arg Asn Gln Lys Lys Arg 
            260                 265                 270         


Leu Tyr Tyr Leu Met Ser Met Ile Gly Gln Leu Arg Gln Phe Ala Phe 
        275                 280                 285             


His Lys Asp Ser Pro Phe Asn Arg Val Trp Leu Tyr Gln Leu Asp Glu 
    290                 295                 300                 


Lys Leu Ser Lys Glu His Lys Asp Thr Leu Asn Tyr Phe Phe Asp Gln 
305                 310                 315                 320 


Arg Tyr Asp Glu Ile His Glu Asn Phe Asn Lys Thr Asn Lys Val Asn 
                325                 330                 335     


Leu Glu Leu Leu Ala Glu Ala Phe Pro Ser Glu Asp Tyr Ala Thr Leu 
            340                 345                 350         


Ala Asn Gln Tyr Tyr Asp Phe Thr Val Phe Lys Ala His Lys Asn Leu 
        355                 360                 365             


Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Leu Ile Glu Asn Ala Leu 
    370                 375                 380                 


Arg Asp Glu Lys Ile Asp Ser Phe Arg Ser Lys Leu Tyr Arg Leu Ile 
385                 390                 395                 400 


Asp Phe Cys Leu Phe Arg Ile Tyr Leu Lys Asp Pro Asp Arg Ala Glu 
                405                 410                 415     


Lys Asn Val Arg Phe Leu Arg Ser Cys Ile Asn Glu Gln Glu Lys Glu 
            420                 425                 430         


Gln Phe Tyr Thr Gln Glu Ala Asn Ala Leu Lys Ser Glu Asn Pro Gly 
        435                 440                 445             


Leu Val Asn Asp Phe Cys Met Gln Leu Lys Asp Arg Tyr Ser Ser Gly 
    450                 455                 460                 


Ser Asn Ser Thr Glu Asn Ala Glu Lys Lys Glu Asp Phe Pro Val Phe 
465                 470                 475                 480 


Pro His Cys His Asp Lys Gln Lys Val Ser Asn Val Ser Leu Phe Ala 
                485                 490                 495     


Lys Leu Met Tyr Ala Phe Cys Leu Phe Leu Asp Gly Lys Glu Ile Asn 
            500                 505                 510         


Glu Leu Leu Ser Ala Leu Leu Asn Lys Phe Asp Thr Ile Ala Cys Met 
        515                 520                 525             


Thr Lys Cys Thr Lys Asp Leu Gly Ile Tyr Ala Pro Phe Ser Lys Asp 
    530                 535                 540                 


Phe Asn Phe Phe Glu Asp Ser Glu Gln Arg Ala Glu Glu Met Asn Leu 
545                 550                 555                 560 


Val Lys Ser Ile Ala Arg Met Thr Lys Pro Asp Ile Gln Ala Lys Glu 
                565                 570                 575     


Gln Leu Phe Arg Asp Ala Leu Asp Ile Leu Gly Val Glu Val Gly Val 
            580                 585                 590         


Ser Glu Glu Ala Leu Gln Lys Glu Ile His Gln Tyr Phe Gln Lys Gly 
        595                 600                 605             


Ala Lys His Asp Phe Arg Asn Phe Ile Ile Asn Asn Val Ile Asn Ser 
    610                 615                 620                 


Thr Arg Phe Ile Tyr Val Ile Lys Phe Cys Asn Pro Lys Thr Ala Gly 
625                 630                 635                 640 


Gln Ile Ile Arg Asn Glu Asn Ile Leu Arg Phe Val Leu Gln Arg Met 
                645                 650                 655     


Pro Gln Glu Gln Ile Glu Arg Tyr Tyr His Ala Cys Thr Lys Asn Pro 
            660                 665                 670         


Ser Leu Cys Thr His Asp Glu Lys Ile Gln Cys Leu Ser Asn Ile Ile 
        675                 680                 685             


Met Glu Val Arg Tyr Lys Lys Phe Cys Asn Val Ala Gln Lys Ser Arg 
    690                 695                 700                 


Asp Thr Thr Lys Gln Met Glu Lys Glu Arg Phe Lys Ala Ile Ile Arg 
705                 710                 715                 720 


Leu Tyr Leu Thr Ala Ile Tyr Leu Val Val Lys Asn Leu Val Asn Val 
                725                 730                 735     


Asn Ala Arg Tyr Val Leu Ala Phe His Cys Leu Glu Arg Asp Ala Asp 
            740                 745                 750         


Leu Phe Gly Leu Gln Ile Lys Gln Thr Leu Pro Asp Arg Lys Lys Lys 
        755                 760                 765             


Ser Asp Tyr Leu Lys Leu Ala Val Asp Gln Cys Gly Asp Asn Pro Glu 
    770                 775                 780                 


Asn Lys Pro Lys Gly Tyr Leu Ala Arg Asn Lys Arg Leu Cys Gln Cys 
785                 790                 795                 800 


Val Arg Glu Asp Ile Asp Asn Ala Lys His Leu Asn Gly Asp Ile Thr 
                805                 810                 815     


Asp Tyr Arg Asn Cys Val Ala His Leu Asn Val Val Arg Asn Cys Asp 
            820                 825                 830         


Gln Tyr Leu Glu Asn Ile Asp Thr Val His Ser Tyr Phe Ser Leu Tyr 
        835                 840                 845             


Gln Tyr Leu Val Gln His Tyr Leu Leu Lys Arg Phe Glu Lys Asp Lys 
    850                 855                 860                 


Tyr Arg Cys Lys Asp Asp Leu Ala Ile His Tyr Tyr Ser Gln Val Lys 
865                 870                 875                 880 


Gln Tyr Arg Ser Tyr Val Lys Asp Leu Val Lys Ala Leu Asn Ala Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Thr Val Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Ala Asp Pro Glu Thr Ile Thr Ala 
        915                 920                 


<210>  227
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR1

<400>  227
gaactatagt agtgtgaatt tacactactc taaaac                                 36


<210>  228
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR2

<400>  228
ctactacact ggtgcaaatt tgcactagtc taaaac                                 36


<210>  229
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ga0099364_10024192

<400>  229

Met Ser Gln Ser Thr Lys Thr Lys Ala Lys Arg Met Gly Val Lys Ser 
1               5                   10                  15      


Val Leu Ala His Gly Lys Asp Glu Lys Gly His Ile Lys Leu Ala Ile 
            20                  25                  30          


Thr Ala Phe Gly Lys Gly Asn Lys Ala Glu Leu Ala Ile Gln Thr Asp 
        35                  40                  45              


Glu Lys Gly Ser Asn Leu Ala Lys Thr Tyr Lys Glu Arg Asn Ile Thr 
    50                  55                  60                  


Ala Asn Lys Ile Val Ser Glu Gly Ile Gln Thr Ser Gly Thr Ile Ala 
65                  70                  75                  80  


Gly Glu Gly His Ala Thr Phe Leu Asn Asn Pro Ala Glu His Val Gly 
                85                  90                  95      


Thr Asp Tyr Leu Lys Leu Lys Glu Thr Leu Glu Met Glu Phe Phe Gly 
            100                 105                 110         


Lys Ser Phe Pro Gly Asp Ser Val Arg Ile Gln Ile Ile His Gln Ile 
        115                 120                 125             


Leu Asp Ile Gln Lys Leu Leu Gly Ile Tyr Ile Thr Asp Ile Ile Tyr 
    130                 135                 140                 


Cys Ile Asn Asn Leu Arg Asp Glu Thr His Leu Asp His Glu Ser Asp 
145                 150                 155                 160 


Ile Val Gly Leu Ser Met Ser Asn Thr Asn Val Asn Leu Ala Leu Asn 
                165                 170                 175     


Gln Met Arg Pro Tyr Phe Gly Phe Phe Gly Glu Ala Phe Arg Pro Val 
            180                 185                 190         


Gly Asp Asp Lys Val Lys Glu Ile Thr Leu Ser Asp Glu Val Arg Lys 
        195                 200                 205             


Asn Ile Glu Lys Ile Ile Ala Leu Glu Glu Gln Lys Arg Asn Pro Ser 
    210                 215                 220                 


Thr Pro Arg Phe Lys Gln Glu Asn Ile Asn Leu Glu Ile Glu Asn Ala 
225                 230                 235                 240 


Met Gly Lys Phe Lys Ser Lys Asp Ala Phe Glu Thr Ala Lys Lys Lys 
                245                 250                 255     


Tyr Asn Arg Ile Val Ala Asp Glu Thr Asn Ala Lys Thr Leu Arg Ile 
            260                 265                 270         


Leu Gly Ala Met Arg Gln Ile Thr Ala His Phe Lys Asp Gln Ala Thr 
        275                 280                 285             


Leu Phe Met Ser Asp Val Glu Leu Pro Lys Ile Leu Lys Lys Glu Phe 
    290                 295                 300                 


Ser Lys Ala Asp Trp Gln Thr Val Glu Asp Tyr Tyr Ala Lys Leu Val 
305                 310                 315                 320 


Asp Arg Ile Asn Glu Gly Phe Cys Lys Asn Ala Ala Thr Asn Val His 
                325                 330                 335     


Phe Leu Thr Glu Leu Leu Pro Glu Glu Ser Lys Lys Gln Leu Thr Glu 
            340                 345                 350         


Asp Tyr Phe Arg Phe Ala Ile Leu Lys Glu Gly Lys Asn Leu Gly Val 
        355                 360                 365             


Asn Met Lys Arg Leu Arg Glu Val Met Phe Ala Leu Phe Val Pro Glu 
    370                 375                 380                 


Leu Thr Ala Pro Glu Thr Lys Lys Arg Tyr Asp Ser Tyr Arg Ala Lys 
385                 390                 395                 400 


Ile Tyr Gly Leu Thr Asp Phe Leu Leu Phe Lys His Ile His Asn Thr 
                405                 410                 415     


Lys Gln Leu Glu Glu Trp Val Ala Val Leu Arg Glu Thr Ser Asn Glu 
            420                 425                 430         


Asp Ala Lys Glu Asn Leu Tyr Asp Glu Phe Ala Arg Thr Ala Trp Asn 
        435                 440                 445             


Thr Val Gly Asp Ser Ala Lys Gln Leu Ile Glu Asn Met Gln Ser Tyr 
    450                 455                 460                 


Phe Thr Lys Lys Glu Lys Glu Ile Thr Lys Thr Ala Gln Pro Val Leu 
465                 470                 475                 480 


Ser Thr Ser Ser Ile Ala His Thr Ser Lys Lys Ile Thr Gln Phe Ser 
                485                 490                 495     


Ser Phe Ala Lys Leu Leu Ala Phe Leu Cys Asn Phe Trp Glu Gly Lys 
            500                 505                 510         


Glu Ile Asn Glu Leu Leu Ser Ala Tyr Ile His Lys Phe Glu Asn Ile 
        515                 520                 525             


Gln Glu Phe Ile Asn Leu Leu Glu Lys Leu Glu Gly Lys Lys Pro Gln 
    530                 535                 540                 


Phe Thr Glu Asn Tyr Ala Leu Phe Asn Glu Ala Ala Gly Gln Arg Ala 
545                 550                 555                 560 


Gly Glu Ile Ala Gln Asn Leu Arg Ile Leu Ala Ser Ile Gly Lys Met 
                565                 570                 575     


Lys Pro Asp Leu Gly Asp Ala Lys Arg Gln Leu Tyr Lys Ala Ala Ile 
            580                 585                 590         


Glu Met Leu Gly Ile Asp Thr Glu Glu Tyr Ile Ser Asp Glu Trp Leu 
        595                 600                 605             


Glu Pro Asn Met Leu Leu Ala Gln Pro Pro Lys Glu Pro Lys Lys Asp 
    610                 615                 620                 


Asn Glu Lys Tyr Arg Lys Glu Pro His Lys Tyr Ser Tyr Glu Lys Asp 
625                 630                 635                 640 


Met Glu Thr Tyr Arg Lys Lys Leu Arg Glu Tyr Glu Glu Thr Trp Arg 
                645                 650                 655     


Ser Leu Ile Asp Tyr Glu Tyr Leu Met Pro Glu Thr Asn Pro Phe Arg 
            660                 665                 670         


Asn Phe Val Ala Lys Gln Val Ile Glu Ser Arg Arg Phe Met Tyr Leu 
        675                 680                 685             


Val Arg Tyr Thr Lys Pro Lys Thr Val Arg Ala Leu Met Ser Asn Arg 
    690                 695                 700                 


Ala Ile Val His Tyr Val Leu Ser Arg Ile Ala Asp Ile Gln Asp His 
705                 710                 715                 720 


His Met Thr Glu Ser Gln Ile Asp Arg Tyr Tyr Gln Asn Leu Pro Gln 
                725                 730                 735     


Tyr Asn Glu Gln Gln His Lys Asn Val Ser Leu Glu Thr Lys Ile Asp 
            740                 745                 750         


Ala Leu Ala Asp Tyr Leu Cys Lys Tyr Thr Phe Glu Lys Asn Val Leu 
        755                 760                 765             


Lys Gln Lys Asn Gly Ile Val Leu Asn Thr Lys Ser Ala Thr Lys Asn 
    770                 775                 780                 


Val Glu Ile Glu His Leu Lys Ala Leu Thr Gly Leu Tyr Leu Thr Val 
785                 790                 795                 800 


Ala Tyr Ile Ala Val Lys Asn Leu Val Lys Ala Asn Ala Arg Tyr Tyr 
                805                 810                 815     


Ile Ala Phe Ser Ile Phe Glu Arg Asp Tyr Ala Leu Phe Glu Lys Lys 
            820                 825                 830         


Leu Gly Lys Asp Thr Leu Glu Lys Tyr Val Lys Pro Phe Lys Tyr Ile 
        835                 840                 845             


Asp Lys Gly Glu Glu Lys Glu Gly Lys Asn Asn Phe Phe Ala Leu Thr 
    850                 855                 860                 


Glu Tyr Leu Leu Asp Lys Asp Asn Ser Leu Arg Tyr Gln Trp Asn Asn 
865                 870                 875                 880 


Asp Leu Ser Asp Glu Glu Asn Lys Gln Ala Leu Arg Lys His Leu Asp 
                885                 890                 895     


Lys Lys Glu Ile Arg Ser Gln Arg His Phe Ser Gln Tyr Trp Leu Asp 
            900                 905                 910         


Ile Phe Ala Arg Gln Ile Glu Asn Ala Lys Lys Thr Ser Glu Ser Gly 
        915                 920                 925             


Tyr Leu Leu Thr Ala Ala Arg Asn Cys Ala Leu His Leu Asn Val Leu 
    930                 935                 940                 


Thr Ala Leu Pro Glu Phe Val Gly Glu Phe Arg Lys Thr Gly Asp Lys 
945                 950                 955                 960 


Met Thr Ser Tyr Phe Glu Leu Tyr His Phe Leu Leu Gln Lys Leu Met 
                965                 970                 975     


Leu Ala Glu Ala Gly Leu Asn Leu Asp Glu Tyr Arg Glu Arg Ile Asp 
            980                 985                 990         


Thr Tyr Gln Thr Ala Cys Lys Asp  Leu Ile Asn Ile Thr  Tyr Val Ser 
        995                 1000                 1005             


Leu Gly  Tyr Asn Leu Pro Arg  Tyr Lys Asn Leu Thr  Cys Glu Pro 
    1010                 1015                 1020             


Leu Phe  Asp Glu Glu Ser Ala  Thr Gly Lys Glu Arg  Gln Thr Arg 
    1025                 1030                 1035             


Leu Asp  Glu Lys Ser Lys Glu  Lys Lys Gln Arg Lys  Gly Gly Gln 
    1040                 1045                 1050             


Lys 
    


<210>  230
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  230
gtgcagtagc cttacagatt cgtagggttc tgagac                                 36


<210>  231
<211>  971
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ga0187910_10006931

<400>  231

Met Ile Glu Lys Lys Lys Ser Tyr Ala Lys Gly Met Gly Leu Lys Ser 
1               5                   10                  15      


Thr Leu Val Ser Asp Ser Lys Val Tyr Met Thr Ser Phe Gly Asn Gly 
            20                  25                  30          


Asn Asp Ala Arg Leu Glu Lys Val Val Glu Asn Asn Ala Ile Ser Cys 
        35                  40                  45              


Leu Val Asp Lys Lys Glu Ala Phe Val Ala Glu Ile Thr Asp Lys Asn 
    50                  55                  60                  


Ala Gly Tyr Lys Ile Ile Asn Lys Lys Phe Gly His Pro Lys Gly Tyr 
65                  70                  75                  80  


Asp Val Val Ala Asn Asn Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp 
                85                  90                  95      


Met Leu Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Gly Ser Ser 
            100                 105                 110         


Val Ser Gly Asn Asp Asn Ile Cys Ile Gln Val Ile His Asn Ile Leu 
        115                 120                 125             


Asp Ile Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala 
    130                 135                 140                 


Val Asn Asn Ile Ala Gly Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys 
145                 150                 155                 160 


Phe Ser Thr Val Tyr Thr Phe Asp Glu Phe Ala Glu Pro Asp Arg His 
                165                 170                 175     


Lys Glu Arg Phe Ile Lys Asp Gly Lys Leu Asp Thr Lys Leu Ile Asn 
            180                 185                 190         


Gln Leu Lys Asn Gln Tyr Asp Glu Phe Asp Ala Phe Leu Asp Asp Thr 
        195                 200                 205             


Arg Phe Gly Tyr Phe Gly Lys Ala Phe Phe Cys Lys Glu Gly Asp Lys 
    210                 215                 220                 


Tyr Leu Asn Lys Gln Asp Asn Glu Arg Tyr His Ile Leu Ala Leu Leu 
225                 230                 235                 240 


Ser Gly Leu Arg Asn Trp Val Val His Asn Asn Glu Val Glu Ser Lys 
                245                 250                 255     


Ile Asp Arg Lys Trp Leu Tyr Asn Leu Asp Lys Asn Leu Asp Lys Glu 
            260                 265                 270         


Tyr Ile Thr Thr Leu Asp Tyr Met Tyr Ser Asp Ile Ala Asp Glu Leu 
        275                 280                 285             


Thr Lys Ser Phe Ser Lys Asn Ser Ala Ala Asn Val Asn Tyr Ile Ala 
    290                 295                 300                 


Glu Ile Leu Asn Ile Asp Ser Lys Thr Phe Ala Glu Gln Tyr Phe Arg 
305                 310                 315                 320 


Phe Ser Ile Met Lys Glu Gln Lys Asn Leu Gly Phe Thr Leu Thr Lys 
                325                 330                 335     


Leu Arg Glu Cys Met Leu Asp Arg Glu Glu Leu Ser Asp Ile Arg Asp 
            340                 345                 350         


Asn His Lys Val Phe Asp Ser Ile Arg Ser Lys Leu Tyr Thr Met Met 
        355                 360                 365             


Asp Phe Val Ile Tyr Arg Tyr Tyr Ile Glu Glu Ala Lys Lys Ile Glu 
    370                 375                 380                 


Asn Glu Asn Lys Thr Leu Ser Asp Asp Lys Lys Lys Leu Ser Glu Lys 
385                 390                 395                 400 


Asp Ile Phe Ile Ile Ser Leu Arg Gly Ser Phe Ser Glu Glu Gln Lys 
                405                 410                 415     


Asp Lys Leu Tyr Ser Asp Glu Ala Glu Arg Leu Trp Ala Lys Leu Gly 
            420                 425                 430         


Lys Leu Met Leu Glu Ile Lys Lys Phe Arg Gly Gln Met Thr Arg Asp 
        435                 440                 445             


Tyr Lys Lys Ser Asp Thr Pro Thr Leu Asn Arg Ile Leu Pro Glu Ser 
    450                 455                 460                 


Glu Asp Val Ser Thr Phe Ser Lys Leu Met Tyr Ala Leu Thr Met Phe 
465                 470                 475                 480 


Leu Asp Gly Lys Glu Ile Asn Glu Leu Leu Thr Thr Leu Ile Asn Lys 
                485                 490                 495     


Phe Asp Asn Ile Gln Ser Met Leu Lys Ile Met Pro Leu Ile Gly Val 
            500                 505                 510         


Asn Ala Lys Phe Ser Ser Asp Tyr Ala Phe Phe Asn Asn Ser Glu Lys 
        515                 520                 525             


Ile Ala Asp Glu Leu Lys Leu Ile Lys Ser Phe Ala Arg Met Gly Glu 
    530                 535                 540                 


Pro Val Ala Asn Ala Lys Arg Asp Met Met Ile Asp Ala Ile Lys Ile 
545                 550                 555                 560 


Leu Gly Thr Asp Leu Asp Asp Asn Glu Ile Lys Lys Leu Ala Asp Ser 
                565                 570                 575     


Phe Phe Lys Asp Ser Asn Gly Lys Leu Leu His Lys Gly Lys His Gly 
            580                 585                 590         


Met Arg Asn Phe Ile Ile Asn Asn Val Val Asn Asn Lys Arg Phe His 
        595                 600                 605             


Tyr Ile Ile Arg Tyr Gly Asp Pro Ala His Leu His Glu Ile Ala Lys 
    610                 615                 620                 


Asn Glu Val Val Val Arg Phe Val Leu Gly Arg Ile Ala Asp Ile Gln 
625                 630                 635                 640 


Lys Lys Gln Gly Lys Gly Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu 
                645                 650                 655     


Ile Cys Ile Gly Asn Gly Tyr Gly Lys Ser Val Ser Glu Lys Ile Asp 
            660                 665                 670         


Ala Leu Thr Lys Val Ile Ile Asn Met Asn Tyr Asp Gln Phe Glu Ala 
        675                 680                 685             


Lys Arg Lys Val Ile Glu Asn Thr Gly Arg Asp Asn Ala Glu Arg Glu 
    690                 695                 700                 


Lys Tyr Lys Lys Ile Ile Ser Leu Tyr Leu Thr Val Ile Tyr Gln Ile 
705                 710                 715                 720 


Leu Lys Asn Leu Val Asn Val Asn Ser Arg Tyr Val Ile Gly Phe His 
                725                 730                 735     


Cys Val Glu Arg Asp Ala Gln Leu Tyr Lys Glu Lys Gly Tyr Asp Ile 
            740                 745                 750         


Asn Thr Asn Asn Leu Glu Ser Lys Gly Phe Thr Ser Val Thr Lys Leu 
        755                 760                 765             


Cys Val Gly Ile Ala Asp Asp Asp Pro Val Lys Tyr Lys Asn Val Glu 
    770                 775                 780                 


Ile Glu Leu Lys Glu Arg Ala Leu Ala Ser Phe Asp Ala Leu Glu Lys 
785                 790                 795                 800 


Glu Asn Pro Glu Leu Tyr Glu Lys Tyr Asn Met Tyr Ser Glu Lys Gln 
                805                 810                 815     


Lys Glu Ala Glu Leu Glu Lys Gln Ile Asn Arg Glu Lys Ala Lys Thr 
            820                 825                 830         


Ala Leu Asn Ala His Leu Arg Asn Thr Lys Trp Asn Val Ile Ile Arg 
        835                 840                 845             


Glu Asn Ile Arg Asn Thr Glu Lys Asp Ala Cys Lys Gln Phe Arg Asn 
    850                 855                 860                 


Lys Ala Asp His Leu Glu Val Ala Arg Tyr Ala Tyr Lys Tyr Ile Asn 
865                 870                 875                 880 


Asp Ile Ser Glu Val Asn Ser Tyr Phe Gln Leu Tyr His Tyr Ile Met 
                885                 890                 895     


Gln Arg Ile Ile Ile Asp Ser Ser Gly Asn Asn Ala Asn Gly Met Ile 
            900                 905                 910         


Lys Lys Tyr Tyr Glu Ser Val Ile Ser Asp Lys Lys Tyr Asn Asp Arg 
        915                 920                 925             


Leu Leu Lys Leu Leu Cys Val Pro Phe Gly Tyr Cys Ile Pro Arg Phe 
    930                 935                 940                 


Lys Asn Leu Ser Ile Glu Ala Leu Phe Asp Lys Asn Glu Ala Ala Lys 
945                 950                 955                 960 


Tyr Asp Lys Ile Lys Lys Lys Val Ala Val Arg 
                965                 970     


<210>  232
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  232
catgtaaacc cctaacaaat ggtaggggtt tgaaac                                 36


<210>  233
<211>  1105
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ga0187910_10015336

<400>  233

Met Glu Asn Val Lys Asn Pro Lys Glu Ile Val Lys Gly Ala Lys Val 
1               5                   10                  15      


Arg Phe Glu Ile Tyr Glu Asn Pro Lys Pro Lys Lys Gln Asn Gln Arg 
            20                  25                  30          


Phe Ser Ala Ile Asn Val Glu Val Ile Thr Asp Glu Thr His Lys Glu 
        35                  40                  45              


Ala Lys Ile Gln Lys Asn Glu Phe Lys Thr Phe Asp Gln Phe Thr Lys 
    50                  55                  60                  


Glu Leu Gln Glu Thr Gln Lys Val Asn Gly Glu Thr Lys Lys Glu His 
65                  70                  75                  80  


Ile Thr Lys Asn Lys His Thr Asn Val Lys Ala Ala Gly Val Lys Ser 
                85                  90                  95      


Val Phe Ala Val Asp Asp Gly Asn Val Leu Ile Thr Ser Phe Gly Arg 
            100                 105                 110         


Gly Asn Ala Ala Asp Ile Glu Thr Leu Lys Ser Asp Asp Asp Lys Thr 
        115                 120                 125             


Ile Asn Leu Thr Glu Thr Glu Asn Gln Lys Lys Tyr Val Val Thr Asn 
    130                 135                 140                 


Lys Arg Ser Asn Val Lys Gly Leu Ala Asp Asn Pro Thr Lys Val Glu 
145                 150                 155                 160 


Ser Ile Ile Pro Gly Glu Thr Gln Ile Gly Phe Lys Ser Ile Leu Glu 
                165                 170                 175     


Lys His Phe Phe Gly Arg Thr Phe Asn Asp Asn Ile His Ile Gln Ile 
            180                 185                 190         


Ile His Asn Ile Leu Asp Ile Lys Lys Ile Leu Ala Val His Thr Asn 
        195                 200                 205             


Asn Ile Val Tyr Ala Leu Asp Asn Ile His Glu Arg Gly Arg Glu Asn 
    210                 215                 220                 


Ser Ala Glu Lys Pro Ile Asp Met Ile Gly Ala Gly Gly Ile Ser Thr 
225                 230                 235                 240 


Ser Lys Glu Tyr Glu Gln Tyr Cys Ser Glu Lys Ser Asp Tyr Glu Asp 
                245                 250                 255     


Asn Phe Leu Lys Gln Leu Ile Asn Asn Glu Arg Ile Ala Tyr Phe Gly 
            260                 265                 270         


Asn Ala Phe Phe Lys Asp Glu Gly Asn Lys Lys Val Met Arg Thr Glu 
        275                 280                 285             


Lys Glu Ile Tyr Tyr Ile Leu Gly Met Leu Asn Glu Val Arg Asn Val 
    290                 295                 300                 


Ser Thr His Phe Thr Glu Glu Asp Asn Arg Asp Trp Ala Lys Ala Asn 
305                 310                 315                 320 


Leu Tyr Asn Leu Ser Asn Arg Leu Lys Val Gly Ser Lys Glu Val Leu 
                325                 330                 335     


Asn Gln Leu Tyr Lys Glu Lys Ile Asp Lys Ile Asp Ala Asn Gly Phe 
            340                 345                 350         


Val Asn Lys Gly Cys Lys Arg Asp Phe Ser Ile Leu Phe Lys Ser Leu 
        355                 360                 365             


Asn Leu Thr Thr Asp Lys Asp Lys Gly Glu Leu Val Val Gly Phe Tyr 
    370                 375                 380                 


Asp Phe Ser Ile Arg Lys Asn Tyr Lys Asn Ile Gly Phe Ser Ile Lys 
385                 390                 395                 400 


Thr Leu Arg Glu Tyr Met Leu Lys Ile Ser Asn Ser Thr Leu Cys Ala 
                405                 410                 415     


Asp Thr Ile Ser Asn Asn Ala Ile Arg Pro Lys Ala Tyr Lys Leu Tyr 
            420                 425                 430         


Asp Phe Ile Ile Trp His Tyr Tyr Met Asn Lys Pro Asp Lys Ile Asn 
        435                 440                 445             


Asp Phe Val Glu Lys Leu Arg Thr Gln Asn Lys Asn Asp Glu Lys Ile 
    450                 455                 460                 


Lys Leu Tyr Tyr Asp Glu Ala Val Cys Leu Leu Ser Glu Leu Gly Arg 
465                 470                 475                 480 


Glu Ile His Thr Met Thr Ser Cys Val His Asn Ile Glu Asn Thr Ser 
                485                 490                 495     


Tyr Glu Ile Thr Asp Lys Lys Gln Lys Glu Tyr Tyr Lys Met Gln Ile 
            500                 505                 510         


Asn Ser Leu Asn Ser Ala Asp Lys Val Ser Asp Phe Ser Lys Val Ile 
        515                 520                 525             


Tyr Leu Val Thr Leu Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu 
    530                 535                 540                 


Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Ala Ser Leu Leu Ser Val 
545                 550                 555                 560 


Leu Glu Lys Gln Ser Gly Lys Lys Val Glu Phe Val Glu Asn Tyr Ser 
                565                 570                 575     


Phe Phe Asn Ser Ser Asn Leu Leu Lys Glu Lys Thr Leu Asn Lys Ser 
            580                 585                 590         


Glu Asn Tyr Thr Cys Lys Ile Val Glu Glu Leu Arg Glu Ile Asn Ser 
        595                 600                 605             


Phe Ala Arg Met Thr Gly Asp Cys Lys Ile Arg Lys Ser Ala Phe Glu 
    610                 615                 620                 


Asp Ala Ser Gln Leu Leu Gly Tyr His Asp Lys Thr Val Asn Asn Leu 
625                 630                 635                 640 


Phe Glu Val Leu Arg Leu Lys Glu Leu Glu Ser Lys Asp Trp Lys Lys 
                645                 650                 655     


Arg Thr Asp Asp Glu Gln Gln Glu Tyr Asp Arg Leu Leu Asn Lys His 
            660                 665                 670         


His Tyr Phe Lys Ser Gly Lys Lys Leu Pro Asp Thr Gly Leu Arg Asn 
        675                 680                 685             


Phe Ile Ile Asn Asn Val Ile Glu Ser Arg Arg Phe Asn Tyr Ile Val 
    690                 695                 700                 


Arg Tyr Ala Asp Pro Lys Lys Ile Arg Lys Cys Thr Glu Asn Asn Glu 
705                 710                 715                 720 


Leu Leu Lys Phe Ala Phe Lys Asp Val Pro Asp Ser Gln Val Asp Arg 
                725                 730                 735     


Tyr Tyr Asn Ile Cys Val Thr Asn Lys Ile Thr Asn Ala Thr Arg Glu 
            740                 745                 750         


Glu Lys Ile Glu Arg Leu Val Asp Ile Ile Lys Ser Met Asn Leu Ser 
        755                 760                 765             


Lys Val Ala Thr Val Lys Gln Arg Asp Lys Gln Asp Asn Val Glu Lys 
    770                 775                 780                 


Gln Lys Gln Leu Ala Ile Met Ser Leu Tyr Leu Asn Ile Leu Tyr Gln 
785                 790                 795                 800 


Ile Ala Lys Asn Leu Val Tyr Val Asn Ser Arg Tyr Val Met Ala Phe 
                805                 810                 815     


His Ser Leu Glu Arg Asp Ser Gln Met Leu Phe Asp Ala Tyr Tyr Asp 
            820                 825                 830         


Val Lys Arg Gly Tyr Cys Asp Leu Ser Thr Val Leu Leu Phe Gly Val 
        835                 840                 845             


Asp Asp Leu Gln Asn Arg Asn Arg Gly Ser Tyr Lys Tyr Leu Arg Asp 
    850                 855                 860                 


Asn Arg Arg Ser Asn Lys Asp Val Ile Glu Thr Phe Gly Asp Phe Lys 
865                 870                 875                 880 


Gly Lys Val Ser Lys Val Val Glu Lys Lys Asn Gln Gly Leu Thr Asn 
                885                 890                 895     


Glu Ile Tyr Asp Ser Leu Cys Asn Val Ala Gly Thr Thr Lys Thr Glu 
            900                 905                 910         


Val Gln Asn Glu Ile Lys Ser Ile Leu Lys Ser Asn Gly Leu Asp Glu 
        915                 920                 925             


Ser Ala Ser Ser Tyr Leu Ser His Lys Leu Val Asn Lys Val His Ser 
    930                 935                 940                 


Tyr Lys Tyr Leu Lys Gln Asn Leu Asp Cys Ala Asp Asn Thr Met Ile 
945                 950                 955                 960 


Asn Gln Phe Arg Asn Asn Val Ala His Leu Asn Thr Ile Arg Asn Met 
                965                 970                 975     


Asp Gly Ile Glu Asn Val Thr Gly Ile Thr Ser Tyr Phe Gln Ile Tyr 
            980                 985                 990         


His Tyr Leu Met Gln Lys Ala Leu  Tyr Lys Glu Phe Lys  Lys Cys Arg 
        995                 1000                 1005             


Glu Asn  Ala Val Arg Lys Trp  Ile Pro Tyr Ile Thr  Glu Asn Ala 
    1010                 1015                 1020             


Glu Pro  Lys Tyr Val Tyr Trp  Asn Lys Lys Glu Gln  Gln Glu Val 
    1025                 1030                 1035             


Glu Val  Ser Phe Asn Pro Lys  Ile Phe Gly Tyr Met  Glu Asn Ile 
    1040                 1045                 1050             


Lys Asn  His Ser Asn Thr Tyr  Cys Lys Asp Phe Val  Lys Ala Leu 
    1055                 1060                 1065             


Cys Ala  Pro Phe Ala Tyr Asn  Leu Pro Arg Phe Lys  Asn Leu Ser 
    1070                 1075                 1080             


Ile Glu  Glu Leu Phe Asp Met  His Glu Leu Ser Glu  Glu Pro Lys 
    1085                 1090                 1095             


Glu Ser  Met Lys Leu Thr Asp  
    1100                 1105 


<210>  234
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  234
gaacgacgtc actacacacc gagaggtgtc taaaac                                 36


<210>  235
<211>  927
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ga0187910_10040531

<400>  235

Met Ala Lys Lys Lys Lys Ala Lys Gln Arg Arg Glu Glu Gln Glu Ala 
1               5                   10                  15      


Ala Arg Met Asn Lys Ile Gln Ser Ala Val Lys Ala Lys Ala Glu Thr 
            20                  25                  30          


Ala Pro Ala Val Ser Ser Ala Phe Val Glu Lys Arg Lys Asp Lys Gln 
        35                  40                  45              


Ser Lys Lys Thr Phe Ala Lys Ala Ser Gly Leu Lys Ser Thr Leu Ala 
    50                  55                  60                  


Val Asp Asn Ser Ala Val Met Thr Val Phe Gly Arg Gly Asn Glu Ala 
65                  70                  75                  80  


Lys Leu Asp His Arg Ile Asn Ala Asp Leu Gln Ser Glu Ser Leu His 
                85                  90                  95      


Pro Gln Ala Ala Leu Lys Asn Val His Ala Pro Asn Lys Gln Lys Ile 
            100                 105                 110         


His Phe Ile Gly Arg Met Gln Asp Met Asn Leu Thr Ala Asp His Pro 
        115                 120                 125             


Leu His Ser His Asp Gly Glu Arg Ala Val Gly Ala Asp Leu Leu Cys 
    130                 135                 140                 


Ala Lys Asp Lys Leu Glu Gln Leu Tyr Phe Gly Arg Thr Phe Asn Asp 
145                 150                 155                 160 


Asn Ile His Ile Gln Leu Ile Tyr Gln Ile Leu Asp Ile Gln Lys Ile 
                165                 170                 175     


Leu Ala Leu His Ala Asn Asn Ile Ile Phe Ala Leu Asp Asn Leu Leu 
            180                 185                 190         


His Lys Lys Asn Asp Glu Leu Ser Asp Asp Phe Val Gly Met Gly Arg 
        195                 200                 205             


Met Arg Ala Thr Ile Gly Tyr Asp Ala Phe Arg Asn Ser Thr Asn Gln 
    210                 215                 220                 


Lys Val Gln Glu Thr Tyr Arg Glu Phe Gln Glu Phe Val Arg Arg Lys 
225                 230                 235                 240 


Glu Leu Leu Tyr Phe Gly Ser Ala Phe Tyr Asn Gly Asp Thr Arg Arg 
                245                 250                 255     


Asp Glu Lys Val Ile Tyr His Ile Leu Ser Leu Ala Ala Ser Val Arg 
            260                 265                 270         


Gln Phe Cys Phe His Asn Asp Tyr Thr Ser Asp Asp Gly Lys Gly Phe 
        275                 280                 285             


Ile Lys Ala Asp Trp Met Tyr Arg Leu Glu Glu Ala Leu Pro Ala Glu 
    290                 295                 300                 


Tyr Lys Asp Thr Leu Asp Ala Leu Tyr Leu Glu Gly Val Glu Gly Leu 
305                 310                 315                 320 


Asp Gln Ser Phe Leu Lys Asn Asn Thr Val Asn Ile Gln Ile Leu Cys 
                325                 330                 335     


Ser Ile Phe Asn His Asp Asp Pro Asn Lys Ile Ala Glu Glu Tyr Tyr 
            340                 345                 350         


Gly Phe Leu Met Thr Lys Glu Tyr Lys Asn Met Gly Phe Ser Ile Lys 
        355                 360                 365             


Lys Leu Arg Glu Cys Met Leu Glu Leu Pro Glu Leu Ser Gly Tyr Lys 
    370                 375                 380                 


Glu Asp Gln Tyr Asn Ser Val Arg Ser Lys Leu Tyr Lys Leu Phe Asp 
385                 390                 395                 400 


Phe Ile Ile Ala His Tyr Phe Arg Lys His Pro Glu Lys Gly Glu Glu 
                405                 410                 415     


Met Val Asp Cys Leu Arg Leu Cys Met Thr Glu Asp Glu Lys Asp Ser 
            420                 425                 430         


His Tyr Glu Gly Thr Ala Lys Lys Leu Val Arg Glu Leu Ala Tyr Asp 
        435                 440                 445             


Met Gln Glu Ala Ala Glu Gln Ala Asn Gly Ser Asn Ile Thr Gln Met 
    450                 455                 460                 


Gln Lys Asn Glu Gln Gln Gly Lys Thr Lys Gly Met Phe Ala Ile Arg 
465                 470                 475                 480 


Asp Glu Ile Arg Val Ser Arg Lys Pro Val Ser Tyr Phe Ser Lys Val 
                485                 490                 495     


Ile Tyr Val Met Thr Leu Leu Leu Asp Gly Lys Glu Ile Asn Asp Leu 
            500                 505                 510         


Leu Thr Thr Leu Ile Asn Lys Phe Glu Asn Ile Val Ser Phe Glu Asp 
        515                 520                 525             


Val Leu Arg Gln Leu Asn Val Asp Cys Thr Phe Lys Pro Glu Phe Ala 
    530                 535                 540                 


Phe Phe Gly Tyr Asp Arg Cys Arg Asn Ile Ser Gly Glu Leu Arg Leu 
545                 550                 555                 560 


Ile Asn Ser Phe Ala Arg Met Gln Lys Pro Ser Ala Lys Ala Lys His 
                565                 570                 575     


Val Met Tyr Arg Asp Ala Leu Arg Ile Leu Gly Leu Asp Asn Gly Met 
            580                 585                 590         


Ser Glu Glu Ala Leu Asp Gln Glu Val Arg Arg Ile Leu Gln Ile Gly 
        595                 600                 605             


Ala Asp Gly Lys Pro Ile Lys Asn Ala Asn Lys Gly Phe Arg Asn Phe 
    610                 615                 620                 


Ile Ala Ser Asn Val Ile Glu Ser Ser Arg Phe Arg Tyr Leu Val Arg 
625                 630                 635                 640 


Tyr Asn Asn Pro His Lys Thr Arg Met Ile Ala Gln Asn Glu Ala Ile 
                645                 650                 655     


Val Arg Phe Val Leu Ser Glu Ile Pro Asp Glu Gln Ile Arg Arg Tyr 
            660                 665                 670         


Tyr Asp Val Cys Arg Asp Pro Lys Leu Pro Arg Ser Ser Ser Arg Glu 
        675                 680                 685             


Ala Gln Val Asp Ile Leu Thr Gly Ile Ile Thr Asp Val Asn Tyr Arg 
    690                 695                 700                 


Ile Phe Glu Asp Val Pro Gln Ser Lys Lys Ile Asn Lys Asp Arg Pro 
705                 710                 715                 720 


Asp Ala Asn Asp Arg Met Thr Leu Lys Lys Gln Arg Tyr Gln Ala Ile 
                725                 730                 735     


Val Ser Leu Tyr Leu Thr Val Met Tyr Leu Val Thr Lys Asn Leu Val 
            740                 745                 750         


Tyr Val Asn Ser Arg Tyr Val Met Ala Phe His Ala Leu Glu Arg Asp 
        755                 760                 765             


Ala Tyr Leu Tyr Gly Ile Thr Asn Ile Lys Gly Asp Tyr Arg Lys Leu 
    770                 775                 780                 


Thr Asp Asn Leu Leu Ala Asp Glu Asn Tyr Lys Lys Phe Gly His Phe 
785                 790                 795                 800 


Lys Asn Lys Lys Trp Arg Gly Ile Ala Glu Gln Asn Leu Arg Asn Ser 
                805                 810                 815     


Asp Val Pro Val Ile Lys Ser Phe Arg Asn Met Ala Ala His Ile Ser 
            820                 825                 830         


Val Ile Arg Asn Ile Asp Leu Tyr Ile Gly Asp Ile Gln Lys Val Asp 
        835                 840                 845             


Ser Tyr Phe Ala Leu Tyr His Phe Leu Met Gln Lys Leu Ile Gln Arg 
    850                 855                 860                 


Val Val Pro Glu Asn Thr Lys Gly Leu Ser Asp Gln Thr Lys Lys Tyr 
865                 870                 875                 880 


Tyr Asp Ala Leu Glu Gln Tyr Asn Thr Tyr Cys Lys Asp Phe Val Lys 
                885                 890                 895     


Ala Tyr Cys Thr Pro Phe Ala Tyr Val Thr Pro Arg Tyr Lys Asn Leu 
            900                 905                 910         


Thr Ile Asp Gly Leu Phe Asp Arg Asn Arg Pro Gly Glu Asp Lys 
        915                 920                 925         


<210>  236
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  236
caactactac cctgccaaat ggcagggttc agaaac                                 36


<210>  237
<211>  900
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ga0187911_10069260

<400>  237

Met Ser Thr Lys Lys Arg Phe Arg Tyr Ser Val Ala Ala Lys Ala Ala 
1               5                   10                  15      


Gly Leu Lys Ser Ser Leu Ala Val Asp Thr Asp Arg Thr Val Met Thr 
            20                  25                  30          


Ser Phe Gly His Gly Asn Ala Ala Ile Leu Glu Lys Glu Ile Val Asp 
        35                  40                  45              


Gly Glu Ile Ser Val Leu Asn Ile Glu Asn Pro Ala Phe Asp Ala Val 
    50                  55                  60                  


Ile Asn Asp Lys Lys Tyr Ala Leu Thr Gly His His Ala Gly Val His 
65                  70                  75                  80  


Ala Leu Val Asp Gln Pro Gln Asn Arg Ser Asp Ala Val His Ile Arg 
                85                  90                  95      


Gly Ala Leu Glu Lys Lys Tyr Phe Gly Asp Thr Phe Ala Asp Asn Ile 
            100                 105                 110         


His Val Gln Ile Ala Tyr Asn Ile Leu Asp Ile Thr Lys Ile Leu Thr 
        115                 120                 125             


Val Tyr Ala Asn Asn Val Val Tyr Ala Leu Asn Asn Leu Val His Ala 
    130                 135                 140                 


Asp Asp Asp Thr Gln Ala Asp Glu Leu Asp Ser Leu Gly Asn Phe Ser 
145                 150                 155                 160 


Ala Gly Thr Ser Tyr Ala Lys Ser Lys Ser Lys Ser Lys Ser Lys Gln 
                165                 170                 175     


Gln Asp Phe Val Glu Leu Phe Ile Lys Lys Lys Glu Ile His Gly Tyr 
            180                 185                 190         


Phe Gly Asp Thr Phe Ala Phe Leu Asp Lys Arg Ile Ala Asp Ala Asp 
        195                 200                 205             


Lys Glu Lys Gln Val Tyr Ala Met Leu Ala Cys Leu Gly Ser Leu Arg 
    210                 215                 220                 


Gln Ala Cys Ser His Tyr Arg Ile Arg Tyr Ser Val Asn Gly Lys Asn 
225                 230                 235                 240 


Val Asp Ala Asp Ala Asp Thr Trp Leu Phe Ser Ser Ala Gln Leu Asp 
                245                 250                 255     


Gln Thr Asp Pro Leu Phe Ser Glu Met Leu Asn Arg Ile Tyr Ser His 
            260                 265                 270         


Lys Ile Lys Thr Val Asn Gln Asn Phe Phe Glu Asn Asn Arg Lys Ala 
        275                 280                 285             


Asn Phe Pro Ile Leu Lys Lys Met Tyr Pro Glu Thr Thr Leu Lys Val 
    290                 295                 300                 


Leu Met Asn Glu Tyr Tyr Asp Phe Ser Ile Arg Lys Gly Tyr Lys Asn 
305                 310                 315                 320 


Phe Gly Phe Ser Ile Lys Ser Leu Arg Glu Ala Leu Leu Ser Pro Gln 
                325                 330                 335     


Tyr Glu Ser Leu Ile Gly Val Gln Ile Lys Asp Asn Lys Glu Tyr Asp 
            340                 345                 350         


Thr Val Arg Ser Lys Leu Tyr Gln Leu Phe Asp Phe Ala Leu Thr Arg 
        355                 360                 365             


Tyr Phe Asn Gln His Pro Asp Met Val Asp Ala Phe Val Val Glu Leu 
    370                 375                 380                 


Arg Ser Leu Ala Lys Asp Glu Asp Ala Lys Asn Ala Val Tyr Glu Lys 
385                 390                 395                 400 


Tyr Ala Lys Ala Val Trp Asn Asp Val Lys Gln Pro Ile Ala Val Met 
                405                 410                 415     


Leu Ser Tyr Met Asn Gly Ser Ala Ile Lys Asn Ile Lys Ala Phe Glu 
            420                 425                 430         


Leu Lys Pro Asp Gln Lys Glu Leu Asn Gly Ile Met Asn Ser Asn Ala 
        435                 440                 445             


Leu Asp Val Pro His Phe Cys Lys Leu Val Tyr Phe Leu Thr Arg Phe 
    450                 455                 460                 


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Val Asn Lys 
465                 470                 475                 480 


Phe Asp Asn Ile His Ser Phe Asn Gln Val Leu Thr Ala Leu Gly Leu 
                485                 490                 495     


Ser Ala Ser Tyr Glu Ala Asp Tyr Lys Ile Phe Glu Asp Ser Gly Arg 
            500                 505                 510         


Val Val Glu Tyr Leu Arg Glu Ile Asn Ser Phe Ala Arg Met Thr Val 
        515                 520                 525             


Asp Met Glu Lys Ile Lys Arg Ser Ala Tyr Lys Lys Ala Leu Leu Ile 
    530                 535                 540                 


Leu Gly Ser Ser Lys Tyr Ser Asp Glu Asp Leu Asp Ala Arg Val Asp 
545                 550                 555                 560 


Glu Met Leu Gly Val Asp Tyr Asn Gln Asn Gly Glu Lys Ile Lys Val 
                565                 570                 575     


Arg Val Asp Thr Gly Phe Arg Asn Phe Ile Ala Asn Asn Val Val Glu 
            580                 585                 590         


Ser Ser Arg Phe His Tyr Leu Ile Arg Tyr Cys His Pro Arg Lys Ile 
        595                 600                 605             


Arg Asn Leu Ala Gly Asn Ala Ala Leu Ile Glu Tyr Gln Leu Arg Arg 
    610                 615                 620                 


Leu Pro Glu Leu Gln Ile Leu Arg Tyr Tyr Glu Ala Cys Thr Glu Pro 
625                 630                 635                 640 


Ile Lys Arg Thr Ala Arg Thr Met Asp Glu Lys Ile Gly Thr Leu Ile 
                645                 650                 655     


Asp Leu Ile Val Lys Met Asp Phe Ser Gln Phe Glu Asp Val Gln Gln 
            660                 665                 670         


Asn Asp Arg Val Arg Val Phe Ser Asp Ala Glu Lys Lys Glu Lys Ile 
        675                 680                 685             


Arg Lys Met Arg Glu Lys Gln Arg Tyr Gln Ser Ile Ile Ser Leu Tyr 
    690                 695                 700                 


Leu Thr Met Leu Tyr Leu Ile Val Lys Asn Leu Val Asn Ile Asn Ala 
705                 710                 715                 720 


Arg Tyr Val Met Ala Phe Gln Ala Trp Glu Arg Asp Asn Tyr Leu Leu 
                725                 730                 735     


Leu Gln Leu Ser Gly Lys Glu Ala Glu Ala Glu Tyr Leu Asn Leu Thr 
            740                 745                 750         


Arg His Phe Ile Glu Pro Leu Asp Gly Ala Lys Pro Tyr Leu Lys Lys 
        755                 760                 765             


Arg Pro Val Glu Tyr Leu Lys Lys Asp Met Ala Met Val Gly Asn Ser 
    770                 775                 780                 


Ser Ile Arg His Phe Arg Asn Ala Thr Val His Leu Asn Val Ile Met 
785                 790                 795                 800 


Glu Ala His Arg Tyr Thr Lys Asp Ile Lys Tyr Ile Gly Ser Tyr Tyr 
                805                 810                 815     


Ala Leu Tyr His Tyr Ile Leu Gln Arg His Leu Leu Asp Lys Ile Glu 
            820                 825                 830         


Glu Asp Ser Tyr Ala Glu Lys Thr Val Ser Glu Lys Leu Trp Glu Ser 
        835                 840                 845             


Gln Ile Ser Gln Tyr Gly Thr Tyr Ser Lys Asp Phe Val Lys Ala Leu 
    850                 855                 860                 


Cys Cys Pro Phe Gly Tyr Asn Leu Pro Arg Phe Lys Asn Leu Ser Ile 
865                 870                 875                 880 


Glu Gln Leu Phe Asp Arg Asn Glu Ser Lys Glu Ile Thr Asp Ala Thr 
                885                 890                 895     


Ala Pro Arg Gln 
            900 


<210>  238
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  238
gaactacagc cctgtgaaat aacggggttc taaaac                                 36


<210>  239
<211>  991
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MH0288_GL0082219

<400>  239

Met Lys Lys Met Thr Ala Lys Glu Arg Arg Glu Gln Glu Lys Gln Lys 
1               5                   10                  15      


Arg Ala Glu Val Ile Arg Gly Lys Gln Glu Ala Asn Arg Lys Lys Ala 
            20                  25                  30          


Gln Ala Ala Ala Thr Gln Asp Ala Thr Ala Pro Val His His Lys Asn 
        35                  40                  45              


Ala Lys Ser Leu Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Thr Leu 
    50                  55                  60                  


Pro Thr Gly Glu Leu Leu Met Thr Ser Phe Gly Arg Gly Ser Glu Ala 
65                  70                  75                  80  


Leu Ile Gln Lys Arg Ile Met Lys Asp Val Ile Ser Asp Val Gln Glu 
                85                  90                  95      


Gly Asp Pro Ala Phe Ser Val Ile Pro Met Pro Lys Gln Phe Glu Ile 
            100                 105                 110         


Gln Gly Arg Ala Ile Asp Val Gln Lys Glu Gly Ser Ser Val Pro Glu 
        115                 120                 125             


Val Leu Thr Asp Asp Pro Arg Ala Ser Gln Lys Pro Ala Gly Ala Asp 
    130                 135                 140                 


Leu Ile Gly Ala Lys Pro Ala Leu Glu Lys Arg Tyr Phe Gly Lys Thr 
145                 150                 155                 160 


Phe Thr Asp Asn Ile His Ile Gln Leu Ile Tyr Arg Ile Leu Asp Ile 
                165                 170                 175     


Lys Lys Val Leu Ala Ile His Ala Asn Asn Ile Val Tyr Thr Leu Asp 
            180                 185                 190         


Asn Leu Ser Arg Arg Glu Gly Thr Glu Gly Thr Asp Phe Ile Gly Ile 
        195                 200                 205             


Gly Gly Leu Thr Leu Lys Asn Ser Tyr Ala Ala Tyr Cys Glu Pro Arg 
    210                 215                 220                 


Thr Phe Phe Asp Glu Gly Lys Glu Lys Asn Ile Ile Glu Asn Ile Glu 
225                 230                 235                 240 


Lys Ser His Gly Glu Phe Leu Glu Tyr Met Lys Asn Pro Arg Leu Ala 
                245                 250                 255     


Tyr Tyr Gly Glu Ala Phe Tyr Arg Arg Leu Ser Asn Asn Glu Arg Ser 
            260                 265                 270         


Lys Leu Gly Met Glu Arg Tyr Glu Arg Met Ser Asp Ala Gln Arg Asp 
        275                 280                 285             


Ala Phe Asp Arg Lys Tyr Pro Ile Asp Phe Cys Asp Gly Glu Leu His 
    290                 295                 300                 


Phe Arg Glu Ile Glu Lys Leu Ala Pro Glu Tyr Val Arg Lys Ser Glu 
305                 310                 315                 320 


Lys Glu Ile Tyr Tyr Ile Leu Ala Met Leu Ser Glu Leu Arg Gln Cys 
                325                 330                 335     


Val Phe His Asp Ser Ala Ala Ser Arg Ser Trp Leu Tyr Asn Leu Glu 
            340                 345                 350         


Lys Val Leu Pro Ala Glu Ala Met Gln Val Leu Asp Gly Val Tyr Ser 
        355                 360                 365             


Gln Lys Val Ala Ala Leu Asn Asn Phe Ser Lys Thr Ser Ser Lys Ser 
    370                 375                 380                 


Asn Phe Arg Leu Leu Phe Asn Ala Leu His Ala Asp Thr Asp Ala Gln 
385                 390                 395                 400 


Lys Lys Gln Ile Ala Glu Asp Phe Tyr Lys Phe Ser Val Arg Lys Thr 
                405                 410                 415     


Tyr Lys Asn Ile Gly Phe Ser Ile Lys Leu Leu Arg Glu Ser Met Leu 
            420                 425                 430         


Asp Thr Phe Ala Pro Glu Tyr Lys Glu Lys Ser Tyr Asp Ser Val Arg 
        435                 440                 445             


Gly Lys Leu Tyr Gln Leu Val Asp Phe Leu Ile Trp Asn Ile Tyr Asp 
    450                 455                 460                 


Lys Asn Glu Lys Met Ala Asp Ala Leu Val Ala Gln Leu Arg Ala Glu 
465                 470                 475                 480 


Val Lys Arg Asp Arg Asp Glu Lys Ser Pro Val Tyr Asp Arg Glu Ala 
                485                 490                 495     


Ala Arg Leu Trp Thr Met Ile Arg Glu Ala Val Ala Gln Thr Ala Lys 
            500                 505                 510         


Thr Leu Arg Ala Val Thr Leu Ser Asn Asn Thr Pro Gly Ser Ile Lys 
        515                 520                 525             


Ile Lys Glu Leu Ala Leu Ser Lys Tyr Asp Arg Asp Leu Val Glu Asn 
    530                 535                 540                 


Ala Ile Asp Ser Ala Val Asp Glu Arg Gly Arg Arg Leu Lys Ile Thr 
545                 550                 555                 560 


Asp Glu Ala Ser Tyr Phe Ser Lys Leu Ile Tyr Leu Leu Thr Leu Phe 
                565                 570                 575     


Leu Asp Gly Lys Glu Ile Asn Asp Leu Ile Thr Thr Leu Val Asn Ser 
            580                 585                 590         


Phe Asp Glu Ile Asp Ser Phe Cys Cys Val Leu Gln Lys Ala Lys Leu 
        595                 600                 605             


Asp Arg Gly Phe Thr Glu Gly Tyr Arg Phe Phe Ala His Ser Ala Glu 
    610                 615                 620                 


Ile Ser Gln Glu Leu Arg Ala Ile Asn Ser Phe Ala Arg Met Thr Thr 
625                 630                 635                 640 


Glu Thr Val Gln Gly Lys Pro Cys Met Phe Glu Asp Ala Ala Asp Leu 
                645                 650                 655     


Leu Gly Met Asp Thr Asp Leu Glu Glu Val Arg Glu Ala Leu Glu Ala 
            660                 665                 670         


Phe Tyr Asn Lys Glu Lys Met Ser Leu Lys Trp Thr Lys Asp Gly Gln 
        675                 680                 685             


Glu Ala Asp Thr Gly Phe Arg Asn Phe Ile Ile Ser Asn Val Leu Lys 
    690                 695                 700                 


Ser Ser Arg Phe Arg Tyr Val Val Arg Tyr Gly Asn Pro Lys Lys Leu 
705                 710                 715                 720 


Arg Glu Val Met Gln Asn Glu Ala Val Val Lys Phe Val Leu Asn Asp 
                725                 730                 735     


Leu Pro Glu Glu Gln Ile Asn Arg Tyr Ser Glu Asn Ile Leu Gly Leu 
            740                 745                 750         


Asp Ala Ala Ala Lys Glu Lys Lys Val Ser Glu Leu Ala Arg Phe Leu 
        755                 760                 765             


Arg Ala Leu Ser Leu Glu Asp Phe Arg Asp Val Glu Gln Ser Ala Asn 
    770                 775                 780                 


Ala Ala Arg Asn Ala Arg Lys Ala Arg Tyr Gln Gly Ala Met Ser Leu 
785                 790                 795                 800 


Tyr Leu Asn Val Ile Tyr Gln Ile Ile Lys Asn Met Val Tyr Ile Asn 
                805                 810                 815     


Ser Arg Tyr Thr Leu Ala Phe Ala Lys Tyr Glu His Asp Ala Ser Leu 
            820                 825                 830         


Leu Leu Asp Asn Trp Val Tyr Asp Pro Tyr Lys Thr Val Phe Ser Asp 
        835                 840                 845             


Leu Thr Glu Asp Ser Leu Gln Lys Gly Lys Leu Asn Arg Arg Ala Ala 
    850                 855                 860                 


Lys Tyr Leu Gln Thr Asn Leu Glu His Ser Asp Asn Thr Leu Ile Arg 
865                 870                 875                 880 


Gln Tyr Arg Asn Ser Val Ala His Leu Asn Ala Val Arg Asn Met Asn 
                885                 890                 895     


Leu Tyr Ile Gly Asp Leu Arg Glu Ile Thr Ser Tyr Phe Gly Ile Tyr 
            900                 905                 910         


His Tyr Ile Met Gln Arg Asp Leu Ile Thr Arg Cys Gln Lys Val Lys 
        915                 920                 925             


Met Lys Asn Pro Val Val Val Gly Tyr Phe Asp Lys Val Arg Thr Tyr 
    930                 935                 940                 


Arg Thr Cys Cys Lys Asp Leu Val Lys Ala Leu Asn Ile Thr Phe Gly 
945                 950                 955                 960 


Tyr Asn Leu Pro Arg Tyr Lys Asn Leu Ser Ile Glu Gly Leu Phe Asp 
                965                 970                 975     


Lys Asn Arg Pro Gly Asp Lys Lys Glu Ser Ala Leu Ile Ala Glu 
            980                 985                 990     


<210>  240
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  240
ccactacacc cctgtcgaac aacgggggtc taaaac                                 36


<210>  241
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  O2.UC29-0_GL0096317

<400>  241

Met Glu Arg Gln Lys Arg Arg Lys Lys Ser Cys Ala Lys Met Ala Gly 
1               5                   10                  15      


Val Lys Ser Thr Phe Val Ile Asp Ser Asp Leu Leu Met Thr Ser Phe 
            20                  25                  30          


Gly Glu Arg Asp Lys Ala Val Arg Glu Lys Tyr Ile Ala Gln Gly Asn 
        35                  40                  45              


Val Lys Ser Leu Arg Lys Gln Glu Gln Ala Phe Asp Ala Gln Tyr Gly 
    50                  55                  60                  


Lys Glu Lys Ile Phe Val Thr Asn Ala Asp Asn Lys Leu His Val Ala 
65                  70                  75                  80  


Ile Asn Asn Pro Leu Cys Gly Asn Lys Lys Gln Ser Pro Glu Ala Gln 
                85                  90                  95      


Glu Tyr Ser Arg Arg Val Leu Glu His Lys Lys Ala Ile Asn Gln Lys 
            100                 105                 110         


Tyr Glu Thr Ile Val Phe Gly Lys Pro Ser Asn Asp Asn Ile His Ile 
        115                 120                 125             


Gln Val Val Ser Lys Ile Met Asp Ile Glu Lys Thr Phe Ser Phe Val 
    130                 135                 140                 


Met Gly Asn Ile Val Tyr Ala Ile Asn Asn Leu Asp Pro Glu Gln Asn 
145                 150                 155                 160 


Ile Asp Asn Pro Ile Asp Tyr Met Ser Asn Lys Ala Arg Thr Asp Glu 
                165                 170                 175     


Asn Leu Lys Arg Val Leu Arg Arg Cys Met Tyr Leu Phe Asp Leu Gly 
            180                 185                 190         


Phe Glu Tyr Ala Glu Pro Ser Pro Tyr Lys Lys Ser Glu Gln Gln Ile 
        195                 200                 205             


Glu Gln Glu Arg Glu Glu Arg Glu Lys Glu Asn Leu Glu Thr Leu Lys 
    210                 215                 220                 


Lys Ala Leu Asp Val Ile Ser Val Met Arg Thr Asp Ser Phe His Gly 
225                 230                 235                 240 


Tyr Asp Met Cys Asn Ser Thr Ser Ala Ile Val Lys Phe Pro Ser Lys 
                245                 250                 255     


Lys Phe Asn Leu Asp Gln Lys Gly Lys Asn Leu Ile Tyr Arg Asn Ala 
            260                 265                 270         


Phe Lys Tyr Lys Thr Asp Thr Ile Lys Lys Gln Tyr Ala Gln Asn Ser 
        275                 280                 285             


Lys Val Asn Ile Asn Phe Leu Ser Tyr Val Leu Tyr Gly Asn Gly Cys 
    290                 295                 300                 


Thr Glu Glu Gln Lys Lys Glu Leu Ser Arg Glu Tyr Phe Asn Phe Ala 
305                 310                 315                 320 


Ile Leu Lys Gln Tyr Lys Asn Leu Gly Phe Ser Ile Thr Ser Leu Arg 
                325                 330                 335     


Glu Gln Leu Leu Ser Leu Tyr Asp Ile Asp Phe Glu Cys Lys Arg Asn 
            340                 345                 350         


Leu Arg Ser Arg Ala Asn Ser Phe Cys Asp Tyr Val Leu Tyr Tyr Arg 
        355                 360                 365             


Tyr Ala Val Gln Phe Pro Glu Arg Ile Val Asp Leu Val Asp Lys Leu 
    370                 375                 380                 


Arg Cys Ser Ala Asn Glu Lys Glu Lys Thr Asn Val Tyr Ile Glu Glu 
385                 390                 395                 400 


Ala Asn Arg Ile Lys Glu Asp Leu Arg Ile Ala Phe Asn Arg Ile Asn 
                405                 410                 415     


Asn Phe Asp Ala Lys Ser Ile Lys Leu Tyr Ser Thr Lys Asn Asn Val 
            420                 425                 430         


Asp Asp Gln Pro Met Leu Pro Phe Glu Gln Val Ser Lys Asp Ile Lys 
        435                 440                 445             


Gly Gly Asp Ala Ala Arg Glu Lys Ala Asp Ala Phe Cys Asp Met Thr 
    450                 455                 460                 


Tyr Tyr Leu Thr Gln Phe Leu Asp Gly Lys Glu Ile Asn Val Phe Leu 
465                 470                 475                 480 


Thr Thr Leu His Asn Leu Phe Glu Asn Ile Ala Ser Phe Leu Asp Val 
                485                 490                 495     


Met His Lys Gln Asn Ile Ser Tyr Asp Phe Thr Glu Gln Tyr Val Met 
            500                 505                 510         


Phe Tyr Asp Ser Ala Tyr Ile Val Lys Lys Leu Glu Thr Val Ile Ser 
        515                 520                 525             


Val Ser Arg Met Lys Lys Ala Leu Asp Phe Tyr Asn Gly Gln Ala Leu 
    530                 535                 540                 


Arg Asp Ala Ile Arg Val Leu Gly Ile Ser Glu Arg His Val Asp Met 
545                 550                 555                 560 


Asp Met Lys Glu Tyr Val Asp Lys Tyr Leu Phe Asp Asp Cys Lys Asp 
                565                 570                 575     


Val Lys His Ala Asp His Asn Leu Arg Asn Phe Ile Val Thr Asn Val 
            580                 585                 590         


Ile Lys Ser Arg Lys Phe Asn Tyr Leu Ala Arg Tyr Ser Asp Met Ala 
        595                 600                 605             


Thr Val Ser Lys Leu Ser Lys Asn Lys Glu Val Val Lys Phe Val Leu 
    610                 615                 620                 


Lys Arg Val Asp Pro Lys Gln Ile Glu Arg Tyr Tyr Arg Ser Val Cys 
625                 630                 635                 640 


Asp Val Arg Asn Ile Ser Ala Glu Asp Glu Ile Glu Lys Leu Val Asp 
                645                 650                 655     


Ile Ile Tyr Asn Phe Asn Ile Asp Glu Leu Glu Gln Val Asn Asn Ala 
            660                 665                 670         


Glu Ile Gly Thr Gly His Ser Gly Arg Lys Val Ala Ser Lys Arg Ser 
        675                 680                 685             


Val Gln Glu Arg Asn Gln Ala Arg Ala Cys Val Ser Leu Tyr Leu Asn 
    690                 695                 700                 


Val Leu Tyr Gln Ile Val Lys Asn Leu Met Asn Val Asn Ser Arg Tyr 
705                 710                 715                 720 


Ser Ile Ala Phe Ala Met Thr Glu Arg Asp Met Ile Val Glu Gly Lys 
                725                 730                 735     


Gly Ile Glu Ala Ile Glu Thr Phe Lys Asp Asp Pro Asp Ala Gly Lys 
            740                 745                 750         


Lys Ser Lys Lys Gln Ile Ala Tyr Arg Thr Lys Tyr Ile Ala Leu Thr 
        755                 760                 765             


Glu Glu Tyr Leu Asp Lys Gly Tyr Ile Lys Cys Ala Thr Glu Arg Ile 
    770                 775                 780                 


Lys Glu Asn Ile Lys Lys Tyr Gly Gly Asp Pro Lys Ser Ile Asp His 
785                 790                 795                 800 


Ile Pro Gly Glu Tyr Ile Lys Lys Asn Leu Glu Gly Tyr Cys Ala Gly 
                805                 810                 815     


Ser Thr Asn Thr Phe Arg Asn Ala Val Ala His Leu Ala Leu Met Ala 
            820                 825                 830         


Arg Val Ser Glu Tyr Ala Ser Asp Ile Lys Asn Val Asn Ser Tyr Phe 
        835                 840                 845             


Ser Leu Tyr His Tyr Cys Met Gln Lys His Ile Leu Tyr Cys Ala Arg 
    850                 855                 860                 


Arg Phe Asn Lys Gln Gly Asn Glu Lys Met Ala Ala Ala Leu Asn Asp 
865                 870                 875                 880 


Ala Glu Ile His Arg Ser Tyr Ser Lys Asp Ala Val Lys Phe Leu Cys 
                885                 890                 895     


Leu Pro Phe Ala Tyr Asn Leu Pro Arg Tyr Lys Ala Leu Thr Val Glu 
            900                 905                 910         


Gly Leu Phe Asp Trp Asn Glu Tyr Gly Gln Asp Asp Asp 
        915                 920                 925 


<210>  242
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  242
gtactaagac cttactaaat ggtaaggttc caaaac                                 36


<210>  243
<211>  954
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PIG-014_GL0226364

<400>  243

Met Thr Lys Pro Glu Lys Lys Gln Ile Lys Gln Ala Thr Leu Thr Lys 
1               5                   10                  15      


Arg Met Gly Leu Lys Ser Thr Leu Val Phe Asp Asn Lys Ile Thr Val 
            20                  25                  30          


Thr Ser Phe Ala Asn Ser Ser Asn Ser Glu Lys Ala Ser Ala His Ile 
        35                  40                  45              


Glu Lys Arg Thr Asp Phe Trp Gly Lys Thr Ile Met Gln Asp Glu Lys 
    50                  55                  60                  


Met Phe Arg Thr Asp Val Glu Lys Gln Gln Ile Tyr Ile Glu Lys Glu 
65                  70                  75                  80  


Phe Pro Asp Glu Asn Asn Lys Ile Ile Thr Gln Thr Ala Met Phe Glu 
                85                  90                  95      


Asn Pro Ala Leu Arg Asn Cys Gly Lys Asp Tyr Ile Gly Met Lys Asn 
            100                 105                 110         


Ser Val Glu Lys Val Met Phe Gly Lys Glu Phe Pro Asn Asp Asn Leu 
        115                 120                 125             


His Ile Gln Ile Ala Tyr Asn Ile Leu Asp Ile Lys Lys Ile Ile Cys 
    130                 135                 140                 


Pro Tyr Ile Asn Asn Val Val Asn Ile Phe Tyr Asn Leu Gly Arg Gly 
145                 150                 155                 160 


Lys Leu Lys Asp Asp Lys Asn Asp Leu Leu Gly Lys Gln Ile Gly Pro 
                165                 170                 175     


Lys Ser Glu Glu Met Val Glu Asp Leu Leu Lys Asn Ser Ser Ala Tyr 
            180                 185                 190         


Phe Val Tyr Phe Gly Asp Val Phe Lys Gln Val Lys Leu Ser Lys Glu 
        195                 200                 205             


Gln Gln Glu Lys Ser Glu Glu Glu Lys Arg Arg Ile Trp Gln Glu Leu 
    210                 215                 220                 


Trp Asn Lys Asn Phe Asp His Asn Lys Asn Ile Val Asn Ser Leu Ile 
225                 230                 235                 240 


Lys Phe Arg Gln Met Cys Phe His Gln Asn Tyr Glu Asn Ser Asp Lys 
                245                 250                 255     


Glu Val Ser Ser Thr Ala Leu Phe Asn Ile Glu Gln Phe Leu Asn Lys 
            260                 265                 270         


Glu Glu Lys Ala Ser Leu Asp Glu Ile Tyr Thr Gly Ala Ile Asp Lys 
        275                 280                 285             


Val Asn Cys Asp Phe Asn Lys Asn Ser Ser Asn Asn Leu Tyr Ile Leu 
    290                 295                 300                 


Glu Gln Ile Tyr Cys Asn Asp Lys Asn Leu Gly Gln Arg Tyr Tyr Asp 
305                 310                 315                 320 


Phe Val Val Lys Lys Ser Gln Cys Asn Leu Gly Leu Asp Thr Lys Leu 
                325                 330                 335     


Ile Arg Glu Leu Leu Ile Arg Lys Leu Ser Asp Glu Gly Leu Asp Ile 
            340                 345                 350         


Asn Asp Ser Arg Tyr Asp Thr Tyr Arg Asn Lys Ile Tyr Thr Val Phe 
        355                 360                 365             


Gly Phe Ile Leu Tyr Tyr Glu Leu Thr Lys Asn Glu Thr Phe Cys Gln 
    370                 375                 380                 


Glu Ile Val Ala Lys Leu Arg Arg Phe Gly Gly Asp Glu Ile Glu Lys 
385                 390                 395                 400 


Asn Lys Ile Tyr Asn Glu Tyr Phe Leu Arg Lys Glu Ala Val Tyr Asn 
                405                 410                 415     


Gln Ile Ala Glu Lys Phe Lys Gln Ser Val Cys Trp Phe Lys Lys Glu 
            420                 425                 430         


Lys Glu Lys Lys Lys Glu Phe Ser Ser Lys Thr Lys Ile Asp Leu Arg 
        435                 440                 445             


Ser Val Gln Lys Ile Glu Asp Gln Asn Ala Ser Val Phe Ala Lys Met 
    450                 455                 460                 


Val Tyr Leu Ile Ser Arg Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu 
465                 470                 475                 480 


Cys Thr Lys Leu Leu Asn Lys Phe Lys Asn Ile Asn Glu Leu Val Glu 
                485                 490                 495     


Thr Ala Lys Arg Cys Gly Glu Thr Ile Glu Phe Cys Pro Glu Tyr Lys 
            500                 505                 510         


Met Phe Lys Asn Ser Ala Lys Leu Ala Glu Glu Met Arg Phe Val Gln 
        515                 520                 525             


Ser Val Ser Lys Met Lys Lys Leu Thr Lys Lys Glu Asp Lys Ser Ile 
    530                 535                 540                 


Lys Pro Gln Val Ile Asp Asp Ala Leu Glu Leu Leu Gly Leu Lys Ile 
545                 550                 555                 560 


Glu Lys Tyr Lys Lys Asp Asp Gln Gly Asn Phe Val Leu Asp Asp Gln 
                565                 570                 575     


Asn His Asn Val Trp Thr Asp Glu Tyr Lys Ser Tyr Arg Lys Glu Cys 
            580                 585                 590         


Phe Thr Pro Lys Asn Ser Asp Ser Met Asn Asp Ala Glu Lys Ser Phe 
        595                 600                 605             


Val Ala Lys Gly His Gln Lys Arg Asn Phe Ile Ile Ser Asn Val Val 
    610                 615                 620                 


Leu Asn Lys Arg Phe Leu Tyr Val Ala Lys Tyr Gly Ser Pro Thr Ala 
625                 630                 635                 640 


Cys Asn Gln Met Met Lys Asn Gln Lys Ile Val Arg Met Ala Leu Glu 
                645                 650                 655     


Ser Ile Ser Glu Asp Gln Leu Arg Lys Tyr Ala Arg Arg Val Tyr Asp 
            660                 665                 670         


Asn Lys Glu His Phe Gln Asn Gln Thr Ala Asp Glu Ile Arg Glu Asn 
        675                 680                 685             


Leu Ala Lys Lys Leu Lys Asn Phe Asn Ile Gly Ala Glu Leu Lys Thr 
    690                 695                 700                 


Val Gly Asn Leu Ser Glu Lys Asp Phe Arg Ser Ser Lys Asn Ala Leu 
705                 710                 715                 720 


Lys Asp Lys Ser Lys Ser Leu Ile Gly Leu Tyr Leu Thr Val Ala Tyr 
                725                 730                 735     


Leu Ile Thr Lys Asn Met Ile Lys Ile Asn Thr Arg Phe Ser Ile Ala 
            740                 745                 750         


Phe Gly Ala Tyr Glu Arg Asp Met Glu Phe Leu Leu Gln Gln Lys Lys 
        755                 760                 765             


Glu Lys Gly Lys Arg Phe Asp Trp Leu Ala Leu Thr Gln Lys Phe Leu 
    770                 775                 780                 


Ser Glu Asp Lys Asn Tyr Tyr Phe Glu His Asp Leu Arg Arg Lys Glu 
785                 790                 795                 800 


Ile Asn Lys Ile Ser Asp Arg Asp Glu Arg Lys Lys Gln His Arg Glu 
                805                 810                 815     


Asn Asp Lys Tyr Tyr Asp Ser Cys Met His Phe Ser Arg His Ser Phe 
            820                 825                 830         


Glu Tyr Ile Ser Lys Asn Phe Ala Glu Val Gln Ser His Pro Asp Pro 
        835                 840                 845             


Leu Lys Leu Phe Ile Lys Tyr Arg Asn Asn Val Met His Leu Asn Ile 
    850                 855                 860                 


Ile Arg Asp Leu Asn Asp Tyr Leu Pro Asp Phe Lys Arg Gly Lys Ala 
865                 870                 875                 880 


Phe Glu Lys Thr Asp Thr Phe Tyr Asp Leu Tyr Cys Tyr Cys Leu Gln 
                885                 890                 895     


Lys Met Leu Leu Ser Glu Val Asp Gly Phe Ser Ala Ile Asn Glu Asn 
            900                 905                 910         


Ile Asp Lys Tyr Cys Thr Ala Ser Lys Asp Phe Met Asn Leu Leu Asn 
        915                 920                 925             


Ile Ile Phe Ala Tyr Asn Val Pro Arg Tyr Lys Asn Leu Ser Asn Lys 
    930                 935                 940                 


Glu Leu Phe Tyr Arg Leu Asp Ser Glu Gln 
945                 950                 


<210>  244
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  244
gtacaaaagc cctccagttt ggacgggttc taagac                                 36


<210>  245
<211>  941
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PIG-018_GL0023397

<400>  245

Met Ala Lys Lys Leu Ser Pro Arg Glu Leu Arg Glu Gln Arg Glu Arg 
1               5                   10                  15      


Glu Arg Gln Ala Lys Phe Ala Lys Gln Val Gln Glu Arg Glu Ala Glu 
            20                  25                  30          


Lys Ala Lys Arg Glu Lys Gln Val Ser Val Ser Asp Thr Val Gly Ala 
        35                  40                  45              


Ala Ala Ala Val Gln Asn Glu Asn Gly Lys Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asp Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Lys Lys Ile Val Asp 
                85                  90                  95      


Glu Ser His Glu Ser Leu Asn Lys Ala Asn Pro Ala Tyr Glu Ile Thr 
            100                 105                 110         


Asp Ile Ser Ser Val Asn Tyr Ser Val Glu Gly His Arg Gly Gln Ser 
        115                 120                 125             


Val Cys Ala Thr Ala Asp Asn Pro Leu His His Asp Gly Gly Ser Ser 
    130                 135                 140                 


Val Pro Thr Asp Met Leu Cys Leu Lys Pro Thr Leu Glu Arg Val Tyr 
145                 150                 155                 160 


Phe Gly Lys Thr Phe Asp Asp Asn Leu His Ile Gln Leu Ile Tyr Asn 
                165                 170                 175     


Ile Leu Asp Ile Glu Lys Ile Leu Ala Ile Tyr Ser Thr Asn Ala Val 
            180                 185                 190         


Tyr Ala Leu Asn Asn Met Ile Ala Asp Glu Asp Asp Glu Ser Ser Asp 
        195                 200                 205             


Leu Phe Gln Asn Met Thr Thr Asp Tyr Thr Tyr Asp Lys Phe Arg Gly 
    210                 215                 220                 


Arg Ser Glu Arg Ile Val Lys Ser Phe Asn Asp Phe Val Ser Asn Pro 
225                 230                 235                 240 


Arg Leu Ala Tyr Tyr Ser Asp Ala Phe Tyr Glu Lys Lys Gly Lys Gly 
                245                 250                 255     


Ser Lys Arg Arg Ser Glu Lys Glu Ile Tyr Ser Met Leu Ala Met Leu 
            260                 265                 270         


Gly Lys Leu Arg His Trp Cys Val His Ser Glu Ser Gly Glu Ala Glu 
        275                 280                 285             


Phe Trp Leu Tyr Lys Leu Asp Ser Leu Asn Gly Glu Phe Ile Asp Val 
    290                 295                 300                 


Leu Asn Thr Leu Tyr Asn Arg Ser Val Asn Glu Ile Asn Arg Gly Phe 
305                 310                 315                 320 


Val Asp Thr Asn Lys Val Asn Ile Gln Ile Leu Gln Ala Val Cys Lys 
                325                 330                 335     


Asn Met Asp Leu Ile Ser Leu Ile Lys Ala Tyr Tyr Glu Phe Leu Ile 
            340                 345                 350         


Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys Leu Arg Glu 
        355                 360                 365             


Met Met Leu Ala Glu Thr Ala Tyr Thr Ser Asn Pro Asp Asp Arg Leu 
    370                 375                 380                 


Tyr Asp Lys Glu Ile Asn Ser Val Arg Asn Lys Leu Tyr Gln Met Thr 
385                 390                 395                 400 


Asp Phe Ile Ile Tyr Leu Glu Tyr Arg Asp Asn Lys Ser Ile Ile Asp 
                405                 410                 415     


Thr Leu Val Ser Lys Leu Arg Ser Ser Val Thr Asp Glu Ala Lys Glu 
            420                 425                 430         


Ala Val Tyr Arg Glu Glu Ala Ala Asn Leu Arg Gly Arg Leu Leu Asp 
        435                 440                 445             


Ala Val Ala Leu Ile Ala Lys Ser Leu Asn Gly Val Asn Ile Lys Lys 
    450                 455                 460                 


Leu Gln Gln Asn Thr Leu Glu Ile Pro Asp Ser Lys Leu Glu Asn Cys 
465                 470                 475                 480 


Phe Ile Lys Ser Ala Glu Lys Val Ser Ala Phe Thr Lys Leu Asn Tyr 
                485                 490                 495     


Leu Leu Thr Arg Phe Ile Asn Gly Lys Glu Ile Asn Asp Leu Leu Thr 
            500                 505                 510         


Thr Leu Ile Asn Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Thr Met 
        515                 520                 525             


Asp Glu Leu Gly Leu Glu Arg Thr Phe Thr Glu Asn Tyr Arg Phe Phe 
    530                 535                 540                 


Glu Asp Ser Gln Lys Tyr Arg Asp Glu Leu Ile Glu Leu Asn Ser Phe 
545                 550                 555                 560 


Ala Lys Ser Cys Ser Phe Asp Ile Ser Ala Lys Arg Ile Met Tyr Arg 
                565                 570                 575     


Asp Ala Leu Asp Ile Leu Gly Ile Gln Ala Glu Leu Ser Glu Asp Glu 
            580                 585                 590         


Ile Gly Arg Met Ile Asp Asn Ile Leu Gln Leu Asp Ala Asn Gly Glu 
        595                 600                 605             


Arg Ile Ser Lys Asn Gln Arg Glu Asn Gly Leu Arg Asn Phe Ile Ala 
    610                 615                 620                 


Ser Asn Val Ile Asp Ser Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly 
625                 630                 635                 640 


Asn Pro Lys Lys Ile Arg Glu Thr Ala Lys Cys Pro Pro Ala Val Lys 
                645                 650                 655     


Phe Val Leu Asp Gly Ile Pro Asp Ser Gln Ile Glu Arg Tyr Tyr Asn 
            660                 665                 670         


Ser Cys Phe Pro Glu Asp Thr Ala Ile Cys Ser Ala Asp Lys Lys Arg 
        675                 680                 685             


Arg Glu Leu Ala Glu Met Ile Ser Asn Ile Ser Phe Asp Trp Phe Lys 
    690                 695                 700                 


Asp Ala Gly Asn Val Gln Arg Val Asn Ala Glu Asp Lys Ser Arg Asn 
705                 710                 715                 720 


Ala Glu Ile Lys Arg Lys Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr 
                725                 730                 735     


Val Met Tyr Leu Met Leu Lys Asn Leu Val Asn Val Asn Ser Arg Tyr 
            740                 745                 750         


Val Ile Gly Phe His Cys Val Glu Arg Asp Ala Lys Leu Tyr Lys Leu 
        755                 760                 765             


Ser Gly Leu Thr Ile Glu Gly Asn Thr Asp Lys Asn Arg Thr Leu Leu 
    770                 775                 780                 


Thr Ala Thr Ile Leu Gly Ile Thr Ser Ala Asp Arg Ala Pro Ser Gly 
785                 790                 795                 800 


Glu Ile Val Ala Asp Cys Asp Leu Gly Arg Ala Glu Thr Ala Ala Asn 
                805                 810                 815     


Arg His Leu Arg Lys Lys Arg Trp Tyr Val Gln Ile Phe Asn Asn Leu 
            820                 825                 830         


Lys Gln Ala Asp Arg Asn Val Ile Asn Glu Phe Arg Asn Ser Val Cys 
        835                 840                 845             


His Leu Asn Ala Ile Arg Asn Ile Asn Thr Asn Ile Glu Gly Ile Gly 
    850                 855                 860                 


Phe Val Lys Asn Tyr Phe Ala Leu Tyr His Tyr Leu Ile Gln Arg His 
865                 870                 875                 880 


Ile Ser Ser Lys Arg Ile Ser Phe Asn Ser Phe Ser Ala Glu Tyr Ile 
                885                 890                 895     


Ser Asn Leu Glu Lys Tyr His Thr Pro Ser Glu Tyr Phe Ile Lys Ala 
            900                 905                 910         


Tyr Cys Thr Pro Phe Ala Tyr Asn Leu Val Arg Tyr Lys Asn Leu Thr 
        915                 920                 925             


Ile Asp Gly Leu Phe Asp Arg Asn Ala Pro Ser Glu Lys 
    930                 935                 940     


<210>  246
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  246
gaactacacc cctgttaaat tgcaggggtc taaaac                                 36


<210>  247
<211>  948
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PIG-025_GL0099734

<400>  247

Met Ala Lys Lys Met Asn Ala Lys Glu Gln Arg Ala Ala Ile Gln Ala 
1               5                   10                  15      


Glu Lys Asn Lys Lys Ile Gln Met Ala Asn Ala Ala Arg Glu Lys Gln 
            20                  25                  30          


Ala Glu Glu Ala Arg Leu Lys Ala Glu Ala Glu Arg Ile Glu Lys Glu 
        35                  40                  45              


Glu Asn Lys Lys Arg Glu Ala Glu Leu Lys Arg Phe Lys Leu Asp Gln 
    50                  55                  60                  


Glu Thr Arg Gly Lys Leu Pro Lys Asn Glu Arg Lys Ser Leu Ala Lys 
65                  70                  75                  80  


Ala Ala Gly Leu Lys Ser Thr Phe Ala Val Gly Thr Asp Leu Tyr Met 
                85                  90                  95      


Thr Ser Phe Gly Lys Gly Asn Asp Ala Ile Val Glu Lys Lys Ile Ser 
            100                 105                 110         


Asn Lys Gln Val Thr Gln Ile Asn Thr Glu Lys Glu Asn Phe Thr Val 
        115                 120                 125             


Asp Thr Asp Gly Ile Thr Asp Thr Ile Val Pro Val Gln Ser Lys Arg 
    130                 135                 140                 


Ile Ala Cys Leu Asn Thr Gln Ala Asp Asn Pro Leu Tyr Arg Lys Asp 
145                 150                 155                 160 


Ser Glu Asn Gln Val Gln Pro Asp Lys Leu Leu Leu Lys Asp Thr Leu 
                165                 170                 175     


Glu Lys Val Tyr Phe Gly Lys Thr Phe Asn Asp Thr Leu His Ile Gln 
            180                 185                 190         


Leu Ile Tyr Asn Ile Leu Asp Ile Gln Lys Ile Leu Thr Val Tyr Ser 
        195                 200                 205             


Val Asn Thr Val Tyr Thr Leu Asn Asn Leu Phe Gly Lys Glu Ile Ser 
    210                 215                 220                 


Glu Arg Gly Asp Phe Ile Gly Ala Leu Ser Phe Gln Gln Thr Tyr Asp 
225                 230                 235                 240 


Asp Tyr Thr Ser Asp Ser Lys Asn Lys Glu Ile Phe Glu Asp Phe Tyr 
                245                 250                 255     


Ser Lys Arg Ser Leu Gly Tyr Tyr Gly His Ile Phe Phe Lys Asp Lys 
            260                 265                 270         


Lys Lys Arg Ser Lys Arg Glu Ile Tyr Asp Ile Leu Ala Leu Ile Ala 
        275                 280                 285             


Thr Ile Arg Gln Trp Cys Ile His Ser Glu Glu Asp Lys Lys Thr Trp 
    290                 295                 300                 


Ile Tyr Asn Ala Glu Asn Val Leu Asp Ser Glu Tyr Leu Asp Ile Leu 
305                 310                 315                 320 


Asp Asp Val Tyr Gly Gly Leu Val Glu Lys Ile Asn Lys Asn Phe Ile 
                325                 330                 335     


Lys Asp Asn Lys Val Asn Leu Ile Leu Leu Ser Asp Ile Leu Asp Met 
            340                 345                 350         


Lys Ser Lys Asp Asp Phe Glu Glu Leu Ile Arg Gln Tyr Tyr Arg Phe 
        355                 360                 365             


Ile Ile Thr Lys Glu Gln Lys Leu Leu Gly Phe Ser Ile Thr Lys Ile 
    370                 375                 380                 


Arg Glu Ala Met Leu Glu Asp Thr Val Phe Lys Thr Asp Lys Lys Tyr 
385                 390                 395                 400 


Asp Ser Ile Arg Ser Lys Leu Tyr Lys Leu Ile Asp Phe Met Met Phe 
                405                 410                 415     


Tyr Lys Tyr Thr Thr Val Asp Ser Glu Lys Glu His Ala Asp Ser Ile 
            420                 425                 430         


Val Glu Lys Leu Arg Ala Thr Leu Ser Gly Glu Ser Lys Glu Glu Ile 
        435                 440                 445             


Tyr Lys Ala Glu Ala Asn Arg Ile Trp Asn Leu Tyr Glu Asp Ile Ile 
    450                 455                 460                 


Met Asn Lys Ile Glu Pro Ala Leu Asp Glu Gly Val Ile Ser Gly Leu 
465                 470                 475                 480 


Lys Lys Asn Lys Ser Tyr Asp Asn Met Ser Ile Glu Gly Ile Val Ala 
                485                 490                 495     


Glu Glu Thr Ala Asn Val Ser Tyr Phe Ser Lys Ile Ile Tyr Leu Leu 
            500                 505                 510         


Ala Gln Phe Ile Asp Gly Lys Glu Val Asn Asp Leu Thr Thr Thr Leu 
        515                 520                 525             


Ile Asn Lys Phe Asp Asn Ile Arg Ser Phe Ile Asp Thr Ala Asn Gln 
    530                 535                 540                 


Ile Gly Leu Glu Cys Asn Leu Leu Asp Glu Tyr Gln Phe Phe Asn Thr 
545                 550                 555                 560 


Ser Asp Thr Val Lys Lys Glu Leu His Val Ile Lys Asn Leu Thr Gly 
                565                 570                 575     


Met Gly Tyr Tyr Asp Val Ser Ile Lys His Gln Met Tyr Lys Asp Ala 
            580                 585                 590         


Ile Asp Ile Leu Gly Leu His Asp Asn Leu Ser Asp Glu Glu Ile Asn 
        595                 600                 605             


Gln Leu Ile Asp Thr Asn Ile Leu Phe Ile Gly Ala Asp Gly Lys Pro 
    610                 615                 620                 


Val Lys Met Ala Lys Gly Lys Arg Gly Phe Arg Asn Phe Ile Ile Ser 
625                 630                 635                 640 


Asn Val Leu Lys Ser Ser Arg Phe Arg Tyr Leu Val Lys Tyr Cys Asn 
                645                 650                 655     


Pro Lys Lys Ile Arg Lys Ile Ala Asn Asn Glu Lys Ile Val Lys Phe 
            660                 665                 670         


Val Leu Gly Arg Ile Thr Glu Thr Gln Ile Glu Arg Tyr Tyr Tyr Ser 
        675                 680                 685             


Cys Asn Pro Glu Leu Lys Arg Ala Ala Tyr Pro Gly Arg Glu Ala Ala 
    690                 695                 700                 


Ile Asp Asp Leu Thr Lys Ile Ile Ile Asn Met Lys Phe Asp Asp Phe 
705                 710                 715                 720 


Lys Asn Val Lys Gln Ser Ala Asn Val Glu Asp Ser Ser Lys Glu Ala 
                725                 730                 735     


Gln Glu Lys Met Lys Tyr Gln Thr Ile Ile Ser Leu Tyr Leu Thr Val 
            740                 745                 750         


Cys Tyr His Leu Val Lys Asn Leu Val Asn Ile Asn Ala Arg Tyr Ala 
        755                 760                 765             


Met Ala Phe His Ser Leu Glu Arg Asp Ala Arg Leu Tyr Gly Ile Tyr 
    770                 775                 780                 


Gly Ser Glu Lys Asp Tyr Val Glu Lys Leu Lys Lys Glu Gln Ala Val 
785                 790                 795                 800 


Leu Val Glu Lys Leu Leu Ser Asp Gly Pro Glu Thr Ala Gly Asn Leu 
                805                 810                 815     


His Leu Arg Ser Lys Lys Trp Asn Arg Leu Met Arg Val Asn Leu Glu 
            820                 825                 830         


Asn Tyr Ser Ala Ala Ala Ser Gln Asn Phe Arg Asn Ala Val Ala His 
        835                 840                 845             


Leu Asn Pro Ile Arg Asn Ala Asp Val Leu Ile Glu Gly Ile Glu Asn 
    850                 855                 860                 


Ile Thr Ser Tyr Phe Asp Ile Tyr His Tyr Ile Val Gln Arg Ser Val 
865                 870                 875                 880 


Leu Asn Arg Thr Asn Lys Thr Pro Lys Met Lys Glu Tyr Glu Glu Leu 
                885                 890                 895     


Ile Asn Lys Tyr His Thr Tyr Asn Lys Asp Phe Val Lys Ala Leu Cys 
            900                 905                 910         


Ala Pro Phe Gly Tyr Asn Val Val Arg Phe Lys Ala Leu Thr Ile Tyr 
        915                 920                 925             


Glu Met Phe Asp Arg Asn Tyr Pro Glu Glu Lys Arg Ala Glu Glu Ala 
    930                 935                 940                 


Arg Lys Ser Cys 
945             


<210>  248
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  248
taatatgccc tatatcaatt tataggggtt cagaac                                 36


<210>  249
<211>  894
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PIG-028_GL0185479

<400>  249

Met Ser Glu Ser Asp Lys Ile Lys Ile Lys Ser Lys Lys Thr Arg Thr 
1               5                   10                  15      


Lys Arg Ala Gly Leu Lys Ser Ser Phe Val Ser Glu Gly Lys Gly Leu 
            20                  25                  30          


Met Thr Ala Phe Gly Lys Gly Asn Asn Ala Val Ile Glu Lys Arg Ile 
        35                  40                  45              


Ser Gly Asp Leu Ile Glu Asn Val Ser Asn Lys Pro Arg Phe Ser Val 
    50                  55                  60                  


Glu Phe Gly Asn Lys Glu Tyr Ile Ile Asn Asp Lys Lys Leu Gly Ile 
65                  70                  75                  80  


Val Ser Asp Asp Pro Arg Glu Ser Gln Lys Pro Val Gly Glu Asp Gly 
                85                  90                  95      


Ile His Cys Lys Arg Ala Leu Glu Glu Arg Tyr Phe Gly Lys Thr Phe 
            100                 105                 110         


Asn Asp Asn Ile His Ile Gln Leu Ile Tyr Ser Ile Leu Asp Leu Glu 
        115                 120                 125             


Lys Ile Leu Ala Val His Ser Asn Asn Ile Val Tyr Thr Phe Asp Asn 
    130                 135                 140                 


Leu Arg Arg Lys Glu Thr Asp Glu Tyr Asp Asp Phe Ile Gly Tyr Met 
145                 150                 155                 160 


Ser Thr Val Asn Ser Tyr Glu Glu Phe Ile Ser Pro Glu Lys Leu Leu 
                165                 170                 175     


Pro Gly Lys Glu Gln Ser Val Tyr Asp Asn Ile Asn Arg Ser Gln Glu 
            180                 185                 190         


Thr Phe Leu Glu Tyr Arg Lys Asn Pro Arg Leu Gly Tyr Phe Gly Lys 
        195                 200                 205             


Val Phe Tyr Glu Lys Ser Thr Asp Ala Lys Asp Lys Asn Lys Lys Lys 
    210                 215                 220                 


Met Arg Leu Ile Ser Glu Lys Glu Met Tyr Tyr Ile Phe Ala Leu Leu 
225                 230                 235                 240 


Gly Gly Leu Arg Gln Phe Cys Thr His Asp Lys Asn Arg Ala Arg Asn 
                245                 250                 255     


Trp Leu Tyr Ser Leu Asp Thr Met Leu Asn Asp Asp Ala Lys Ala Val 
            260                 265                 270         


Leu Asp Lys Tyr Tyr Val Ser Thr Val Ser Ser Leu Asn Lys His Phe 
        275                 280                 285             


Val Glu Asn Ser Ala Lys Lys Asp Phe Ser Ile Ile Phe Asn Ala Leu 
    290                 295                 300                 


Asn Ile Thr Asp Ile Glu Leu Lys Lys Asn Ile Ala Lys Glu Tyr Tyr 
305                 310                 315                 320 


Glu Phe Val Cys Arg Lys Asn Phe Lys Asn Ile Gly Phe Ser Ile Lys 
                325                 330                 335     


Lys Leu Arg Glu Tyr Leu Leu Glu Lys Pro Glu Phe Arg Asn Leu Lys 
            340                 345                 350         


Asp Asp Lys Tyr Asn Ser Val Arg Ser Lys Leu Tyr Arg Leu Ile Asp 
        355                 360                 365             


Phe Ile Ile Tyr Leu Asn Tyr Lys Asp Ala Lys Phe Lys Asn Asp Asn 
    370                 375                 380                 


Asp Glu Lys Ile Glu Arg Phe Val Ser Lys Leu Arg Lys Cys Pro Asp 
385                 390                 395                 400 


Glu Ala Ser Lys Glu Thr Val Tyr Gln Thr Glu Ala Asp Ile Ile Lys 
                405                 410                 415     


Lys Ser Ile Ser Gly Ser Ile Asn Ser Ile Lys Arg Asp Met Met Leu 
            420                 425                 430         


Val Lys Ser Lys Tyr Gly Lys Leu Glu Leu Asp Thr Gln Thr Val Asn 
        435                 440                 445             


Gln Leu Lys Arg Ala Val Asp Asp Ile Ser Ile Asn Thr Lys Gly Asp 
    450                 455                 460                 


Tyr Phe Thr Lys Leu Met Tyr Leu Ile Ser Leu Leu Ile Asp Gly Lys 
465                 470                 475                 480 


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile His Gln Phe Glu Asn Ile 
                485                 490                 495     


Ala Ser Phe Ile Asp Val Met Lys Lys Glu Asn Ile Glu Cys Glu Phe 
            500                 505                 510         


Thr Glu Lys Phe Ala Phe Phe Lys Asn Ser Glu Ile Ile Ala His Glu 
        515                 520                 525             


Leu Arg Thr Val Asn Ser Phe Ala Arg Met Thr Gly Phe Met Glu Asn 
    530                 535                 540                 


Asp Glu Ser Thr Lys Phe Ile Met Phe Arg Glu Ala Ala Asp Ile Leu 
545                 550                 555                 560 


Gly Thr Ser Tyr Thr Asp Asp Glu Leu Thr Asp His Leu Asn Leu Lys 
                565                 570                 575     


Lys Thr Arg Leu Ile Ala Arg Ser Lys Ala Asp Met Gly Leu Arg Asn 
            580                 585                 590         


Phe Ile Ile Ser Asn Val Ile Lys Ser Ser Arg Phe Lys Tyr Leu Ile 
        595                 600                 605             


Arg Tyr Ser Asn Pro Lys Lys Val Lys Ala Ile Ala Glu Asn Lys Lys 
    610                 615                 620                 


Leu Val Ser Phe Val Leu Asp Lys Ile Pro Asp Thr Gln Ile Ile Arg 
625                 630                 635                 640 


Tyr Cys Asn Thr Cys Gly Phe Lys Val Gly Lys Arg Gln Glu Asn Ile 
                645                 650                 655     


Asn Thr Leu Ala Glu Ala Ile Thr Tyr Phe Ser Phe Ser Asn Phe Glu 
            660                 665                 670         


Lys Val Lys Gln Ser Ala Asn Val Glu Asn Asp Thr Pro Asp Ala Ile 
        675                 680                 685             


Asp Lys Ala Gln Lys Gln Gly Leu Ile Ser Leu Tyr Leu Thr Val Leu 
    690                 695                 700                 


Tyr Leu Phe Ile Lys Asn Met Val Tyr Val Asn Ser Arg Tyr Val Leu 
705                 710                 715                 720 


Ala Phe His Cys Leu Glu Arg Asp Ser Gln Leu Leu Lys Ile Thr Ser 
                725                 730                 735     


Gly Tyr Asn Asn Leu Ser Tyr Asn Asn Leu Thr Asn His Phe Ile Glu 
            740                 745                 750         


Lys Glu Tyr Leu Asn Ser His Ala Arg Asn Tyr Leu Arg Val Asn Ile 
        755                 760                 765             


Ser Asn Ser Asp Glu Trp Ser Ile Val Lys Phe Arg Asn Gly Val Ala 
    770                 775                 780                 


His Leu Asn Ser Val Arg Asn Ile Asp Thr Ser Ile Lys Gly Leu Arg 
785                 790                 795                 800 


Glu Phe Lys Ser Tyr Phe Glu Ile Tyr Ala Tyr Thr Val Gln Lys Ser 
                805                 810                 815     


Ile Lys Asn Tyr Tyr Asp Ala Glu Ser Pro Val Gln Ile Asn Pro Lys 
            820                 825                 830         


Thr Ile Glu Tyr Met Glu Ser Val Asp Lys Tyr Gly Ser Tyr Thr Lys 
        835                 840                 845             


Asp Phe Val Lys Ala Leu Asn Thr Pro Phe Gly Tyr Cys Leu Ala Arg 
    850                 855                 860                 


Tyr Lys Asn Leu Ser Ile Glu Pro Leu Phe Asp Arg Asn Thr Val Tyr 
865                 870                 875                 880 


Asn Lys Lys Asp Val Lys Glu Glu Phe Ala Val Asn Ser Lys 
                885                 890                 


<210>  250
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  250
gaactatagc cctccgattt cggagggttc tgaaac                                 36


<210>  251
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ga0224422_10645759

<400>  251

Met Asp Lys Tyr Lys Leu Leu Arg Asn Gln Lys Phe Asp Tyr Val Ile 
1               5                   10                  15      


Lys Leu Asp Asn Ile Asp Asn Ile Arg Pro Ile Leu Cys Lys Glu Ile 
            20                  25                  30          


Val Asn Lys Ile Leu Lys Lys Leu Lys Leu Asp Phe Phe Phe Ser Thr 
        35                  40                  45              


Lys Glu Lys Glu Ile His Phe Thr Ala Asp Asp Ile Ile Thr Lys Lys 
    50                  55                  60                  


Tyr Lys Lys Ile Glu Leu Val Gly Asp Asp Lys Glu Val Phe Pro Ile 
65                  70                  75                  80  


Tyr Val Arg Leu Arg Glu Val Pro Leu Lys Gly Lys Ala Lys Arg Leu 
                85                  90                  95      


Gly Leu Lys Ser Ile Phe Val Glu Asp Asn Lys Leu Ile Leu Thr Thr 
            100                 105                 110         


Ile Gly Lys Lys Asp Asp Val Leu Ile Glu Lys Glu Ile Leu Asn Asn 
        115                 120                 125             


Ser Lys Asn Glu Val Ile Ser His Ile Asn Pro Glu Asn Tyr Ala Val 
    130                 135                 140                 


Gln Glu Val Asn Tyr Lys Asn Ile Ser Leu Ala Asn Asp Lys Leu Lys 
145                 150                 155                 160 


Ala Asp Ile Asp Asn Pro Ser His Ser Lys Val Glu Glu Thr Ile Ser 
                165                 170                 175     


Ile Lys Lys Asp Tyr Leu Glu Arg Lys Asp Val Ile Glu Lys Lys Phe 
            180                 185                 190         


Phe Asn Asn Thr Phe Asn Asp Asn Ile His Ile Gln Leu Ala Tyr Asn 
        195                 200                 205             


Ile Met Asp Ile Asn Lys Ile Phe Asn Ile Tyr Ser Asn Glu Val Val 
    210                 215                 220                 


Phe Thr Met Glu Asn Leu Ala His Ser Asp Asp Ala Lys Asp Phe Ile 
225                 230                 235                 240 


Gly Gly Ile Asp Tyr Lys Lys Asp Val Ile Gln Asn Ala Lys Phe Asn 
                245                 250                 255     


Asp Tyr Phe Ala Ser Ile Phe Asn Ser Leu Arg Tyr Phe Ser Gln Ala 
            260                 265                 270         


Phe Pro Asn Lys Thr Phe Asp Lys Ile Lys Ile Asp Gly Glu Lys Asp 
        275                 280                 285             


Tyr Asn Arg Glu Glu Ile Lys Lys Asn Thr Lys Ile Ile Leu Arg Ile 
    290                 295                 300                 


Leu Ser Met Phe Arg Gln Phe Ser Ile His Gly Tyr Thr Asp Leu Phe 
305                 310                 315                 320 


Asp Met Glu Lys Asp Pro Lys Ile Arg Asp Leu Leu Asp Tyr Phe Thr 
                325                 330                 335     


Ala Arg Tyr Asp Glu Val Tyr Asn Asn Leu Ile Arg Asn Phe Ile Lys 
            340                 345                 350         


Thr Ser Lys Thr Asn Ile Ala Ile Val Phe Glu Ala Leu Asn Leu Pro 
        355                 360                 365             


Ile Asn Asp Asn Gly Leu Lys Lys Glu Ile Leu Asn Asp Tyr Phe Asp 
    370                 375                 380                 


Phe Ser Ile Thr Lys Ser Tyr Val Asn Met Gly Phe Asn Phe Lys Arg 
385                 390                 395                 400 


Leu Lys Glu Val Leu Ile Ser Lys Leu Gly Leu Asn Val Ser Asp Ser 
                405                 410                 415     


Asn Lys Gln Ala Thr Tyr Asn Val Ile Asn Tyr Leu Ile Tyr Arg His 
            420                 425                 430         


Leu Lys Asp Asn Pro Ile Val Asp Lys Tyr Val Lys Cys Leu Val Ala 
        435                 440                 445             


Ser Glu Gly Asp Leu Asp Lys Ile Ala Ile Tyr Asp Ala Phe Ala Asp 
    450                 455                 460                 


Glu Ile Lys Leu Pro Leu Lys Asn Ile Ile Thr Gln Glu Leu Val Asp 
465                 470                 475                 480 


Asn Gln Lys Arg Asn Gln Lys Tyr Lys Tyr Phe Asn Ile Asp Gly Ser 
                485                 490                 495     


Trp Leu Asn Thr Asn Phe Asn Asn Ile Asp Pro Phe Cys Lys Ala Ile 
            500                 505                 510         


Tyr Phe Leu Thr Ile Phe Leu Asp Thr Lys Glu Ile Asn Met Leu Val 
        515                 520                 525             


Thr Ser Ile Val Asn Lys Leu Arg Asn Ile Asn Gly Leu Val Lys Val 
    530                 535                 540                 


Leu Asn Asn Lys Ser Asp Leu Ile Tyr Asp Tyr Arg Ile Phe Asp Lys 
545                 550                 555                 560 


Gly Asn Ala Gln Lys Ile Ala Asp Gln Leu Ser Val Val Leu Ser Ile 
                565                 570                 575     


Ala Arg Met Gln Lys Asn Phe Asn Lys Lys Phe Lys Ser Asp Asn Lys 
            580                 585                 590         


Asn Ser Ala Asn Lys Pro Ser Ser Asp Met Ile Tyr Asp Ala Tyr Cys 
        595                 600                 605             


Leu Phe Gly Tyr Lys Glu Ser Lys Glu Thr Phe Asp Glu Glu Leu Glu 
    610                 615                 620                 


Ala Asp Thr Ser Lys Pro Ser Lys Gly Ile Ala Lys Phe Gln Asn Lys 
625                 630                 635                 640 


Ile Thr Ser Ala Ile Val Asn Ser Asn Lys Phe Arg Phe Ile Ile Lys 
                645                 650                 655     


Tyr Ala Asn Pro Arg Asn Cys Tyr Ser Ile Met Lys Asn Thr Arg Val 
            660                 665                 670         


Val Ser Phe Val Leu Lys Glu Ile Pro Gln Ser Gln Ile Asp Lys Tyr 
        675                 680                 685             


Ile Ile Lys Lys Glu Lys Tyr Asn Ser Leu Asn Tyr Asp Ala Lys Ile 
    690                 695                 700                 


Asn Ala Leu Ala Lys Glu Leu Ala Asp Val Ser Ile Tyr Gly Met Arg 
705                 710                 715                 720 


Lys Ala Tyr Asn Ile Arg Ala Lys Val Glu Ala Asn Asn Leu Glu Leu 
                725                 730                 735     


Pro Lys Leu Phe Met Thr Ile Ile Tyr Gln Val Ile Lys Ser Leu Val 
            740                 745                 750         


Arg Ile Asn Thr Tyr Tyr Asn Ile Ala Phe Ser Cys Leu Glu Arg Asp 
        755                 760                 765             


Lys Lys Leu Phe Asn Val Pro Asp Asp Tyr Cys Asp Tyr Ser Asp Leu 
    770                 775                 780                 


Met Leu Leu Asp Ala Phe Val Tyr Gly Thr Asn Glu Phe Glu Val Ser 
785                 790                 795                 800 


Lys Asp Gly Lys Cys Glu Cys Ile Thr Ile Asp Val Pro Leu Asn Lys 
                805                 810                 815     


Tyr Glu Arg Lys Val Asp Gly Lys Ile Ile Ser Val Gln Gly Thr Lys 
            820                 825                 830         


Leu Gly Ser Ser Lys Tyr Ser Trp Leu Lys Asp Asp Ile Asp Val Phe 
        835                 840                 845             


Lys Glu Ile Phe Tyr Met Asn Asn Lys Pro Thr Glu Ile Glu Ser Cys 
    850                 855                 860                 


Ser Val Ile Tyr Arg Ala Cys Tyr Arg Asn Thr Ile Ala His Leu Asn 
865                 870                 875                 880 


Ala Ile Ser Asn Met Thr Ser Tyr Leu Ala Ser Phe Val Gly Arg Asn 
                885                 890                 895     


Asn Arg Met Asn Ser Tyr Phe Glu Leu Tyr Gln Tyr Ile Ile Gln Met 
            900                 905                 910         


Asn Phe Ile Asn Lys Tyr Lys Asp Asn Tyr Ser Asn Glu Phe Ile Asp 
        915                 920                 925             


Lys Gln Ser Glu Ile Leu Lys Lys Tyr Lys Thr Tyr Ser Lys Asp Leu 
    930                 935                 940                 


Leu His Ile Leu Asn Leu Pro Leu Ala Tyr Asn Met Ala Arg Tyr Lys 
945                 950                 955                 960 


Asn Leu Thr Ile Glu Asp Ile Phe Tyr Asp Lys Phe Ile Asn Tyr Ile 
                965                 970                 975     


Lys Lys Ser Glu 
            980 


<210>  252
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  252
ggacaataac ctgcgaattt tggcaggttc tatgac                                 36


<210>  253
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ODAI chimera

<400>  253

Met Leu Lys Lys Cys Ser Val Cys Gly Lys Lys Phe Glu Thr Asn Tyr 
1               5                   10                  15      


Gln Gly Gly Lys Pro Val Cys Arg Asn Cys Arg Ser Asn Lys Ser Lys 
            20                  25                  30          


Pro Val Asn Pro Lys Ser Ser Arg Lys Pro Glu Ser Ile Asp Lys Ala 
        35                  40                  45              


Ile Glu Ile Leu Thr Glu Lys Leu Ile Ser Asp Cys Lys Lys Asn Asp 
    50                  55                  60                  


Cys Ala Ser Glu Cys Gly Lys Gly Arg Arg Lys Ser Lys Ala Lys Ala 
65                  70                  75                  80  


Ala Gly Leu Lys Ser Ala Leu Asp Leu Gly Asn Gly Gln Ala Leu Ile 
                85                  90                  95      


Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu Lys Arg Val Glu 
            100                 105                 110         


Gly Asp Lys Ile Ile Ser Leu Arg Glu Gly Glu Ala Phe Ala Leu Ala 
        115                 120                 125             


Lys Glu Pro Val Asn His Lys Leu Val Leu Lys Ser Gly Arg Ile Lys 
    130                 135                 140                 


Ala Glu Gly Gly Pro Val Glu Phe Asp Gly Pro Gln Lys Asn Ser Ser 
145                 150                 155                 160 


Met Ser Ala Val Arg Leu Asp Glu Tyr Asn Asn Gln Ile Glu Arg Lys 
                165                 170                 175     


Phe Phe Arg Gly Asn Lys Val Leu Gln Asp Asn Ile Arg Ile Gln Ile 
            180                 185                 190         


Ala His Asn Ile Met Asp Ile Glu Lys Ile Leu Ala Val His Ile Asn 
        195                 200                 205             


Asn Ile Val Tyr Ser Val Asn Asn Leu Phe Arg Val Gln Gly Asn Glu 
    210                 215                 220                 


Gly Asp Asp Phe Leu Gly Tyr Arg Gly Leu Asp Lys Asn Tyr Ser Asp 
225                 230                 235                 240 


Phe Cys Lys Asn Lys Pro Glu Asp Lys Glu Arg Phe Phe Asn Phe Ile 
                245                 250                 255     


Gly Lys Gly Asp Gly Lys Val Thr Asn Pro Arg Leu Ser Tyr Tyr Gly 
            260                 265                 270         


Ala Ala Phe Ala Glu Lys Val Gln Pro Thr Leu Lys Tyr Arg Glu Ala 
        275                 280                 285             


Glu Asp Ile Tyr Tyr Ile Ile Cys Met Leu Gly Glu Ala Arg Gln Met 
    290                 295                 300                 


Phe Ala His Gly Asn Asp Asp Arg Thr Lys Thr Phe Leu Tyr Asn Ile 
305                 310                 315                 320 


Val Gly Tyr Arg Asn Gly Thr Glu Ile Asn Ser Lys Phe Thr Ala Val 
                325                 330                 335     


Leu Asp Gly Ile Tyr Ser Lys Lys Val Glu Glu Leu Asn Gly Asn Phe 
            340                 345                 350         


Ile Lys Asn Ser Lys Lys Asp Leu Thr Ile Leu Phe Ser Ala Phe Gly 
        355                 360                 365             


Cys Gln Asp Glu Ala Ser Lys Lys Lys Leu Ile Glu Lys Tyr Tyr Asp 
    370                 375                 380                 


Phe Ile Val Lys Lys Thr Asn Lys Asn Met Gly Phe Ser Val Thr Lys 
385                 390                 395                 400 


Leu Arg Glu Lys Ile Ile Glu Gly Tyr Arg Phe Arg Gly Asn Pro Val 
                405                 410                 415     


Thr Gly Thr Asp Tyr Asp Ser Val Arg His Lys Leu Tyr Arg Thr Phe 
            420                 425                 430         


Asp Phe Ile Ile Cys Ser Tyr Tyr Asp Asp His Ala Lys Glu Lys Asp 
        435                 440                 445             


Thr Leu Val Ser Ser Leu Arg Ala Ser Leu Asn Asp Thr Lys Lys Glu 
    450                 455                 460                 


Asn Leu Tyr Ala Gly Glu Ala Lys Thr Ile Ala Glu Ser Ile Lys Asp 
465                 470                 475                 480 


Arg Met Asp Thr Val Cys Arg Met Tyr Asn Lys Gly Glu Gly Ile Lys 
                485                 490                 495     


His Ile Thr Val Asp Arg Phe Ile Ala Gly Ala Gly Ala Gly Lys Leu 
            500                 505                 510         


Ile Asp Lys Cys Ser Ile Ser Thr Glu Cys Asp Tyr Phe Cys Lys Phe 
        515                 520                 525             


Ile Tyr Leu Met Thr Leu Phe Ile Asp Gly Lys Glu Ile Asn Asp Leu 
    530                 535                 540                 


Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Asp Ser Pro Ser Val 
545                 550                 555                 560 


Asp Lys Ala Val Asn Asn Gln Asn Arg Val Glu Phe Gly Asp Lys Tyr 
                565                 570                 575     


Asp Met Phe Asn Lys Ala Gly Glu Ile Cys Glu Ser Leu Arg Ser Ile 
            580                 585                 590         


Asn Ser Phe Ala Arg Met Glu Ser Pro Ala Pro Ala Ala Lys Arg Thr 
        595                 600                 605             


Met Phe Val Asp Ala Ile Arg Met Phe Gly Phe Ala Asp Val Ser Asp 
    610                 615                 620                 


Asn Asp Ala Glu Lys Phe Tyr Lys Glu Asn Ile Glu Pro Phe Ile Tyr 
625                 630                 635                 640 


Asp Arg Asn Gly Asp Ile Glu Asp Glu Trp Lys Lys Gly Lys Leu Val 
                645                 650                 655     


His Lys Lys Asp Glu Lys Lys Lys Gly Val Tyr Asn Phe Ile Ala Thr 
            660                 665                 670         


Asn Val Ile Glu Ser Asn Arg Phe Gln Tyr Leu Val Arg Tyr Ala Asn 
        675                 680                 685             


Thr Glu Lys Ile Ala Ala Leu Ala Arg Asn Glu Thr Ile Val Arg Phe 
    690                 695                 700                 


Val Ile Lys Lys Leu Pro Ala Ala Gln Ile Val Arg Tyr Tyr Ile Ala 
705                 710                 715                 720 


Cys Asn Arg Ile Arg Glu Asn Ile Asn Ser Asn Val Leu Thr Ser Asp 
                725                 730                 735     


Asp Met Ala Glu Ser Leu Val Lys Leu Val Thr Gly Met Asp Phe Gly 
            740                 745                 750         


Lys Ile Lys Gly Val Arg Asn Asp Asp Arg Ser Gly Asp Lys Glu Met 
        755                 760                 765             


Lys Lys Ala Ile Val Thr Leu Tyr Leu Thr Ile Leu Tyr His Leu Thr 
    770                 775                 780                 


Lys Asn Leu Val Tyr Val Asn Ser Arg Tyr Phe Met Ala Phe His Cys 
785                 790                 795                 800 


Leu Glu Arg Asp Met Asn Leu Phe Gly Glu Gly Gln Lys Gln Ala Leu 
                805                 810                 815     


Arg Asn Thr Gly Asp Tyr Pro Ala Asp Asn Ala Asp Leu Arg Arg Arg 
            820                 825                 830         


Asp Ile Lys Tyr Cys Val Leu Thr Lys Ala His Ile Lys Gln Glu Glu 
        835                 840                 845             


Val Lys Ser Arg Arg Asn Asp Thr Asp Ser Lys Ser Gln Gln Lys Ala 
    850                 855                 860                 


Lys Ser Arg Arg Arg Arg Trp Cys Leu Leu Leu Lys Glu Asp Ile Asp 
865                 870                 875                 880 


Lys Leu Asn Gly Cys Glu Ser Leu Arg Ile Leu Tyr Arg Asn Ala Val 
                885                 890                 895     


Ala His Leu Asn Ile Pro Arg Asn Ala Ile Asp Tyr Ile Gly Gly Ile 
            900                 905                 910         


Lys Lys Ala Asp Ser Tyr Phe Ala Ile Tyr His Tyr Met Met Gln Gln 
        915                 920                 925             


Tyr Leu Ser Lys Lys His Gly Leu Pro Glu Gly Leu Gly Cys Thr His 
    930                 935                 940                 


Gly Val Tyr Cys Lys Asp Leu Val Lys Ala Leu Asn Ala Pro Phe Gly 
945                 950                 955                 960 


Tyr Asn Leu Pro Arg Phe Lys Asn Leu Ser Val Glu Ala Leu Phe Asp 
                965                 970                 975     


Met Asn Glu Glu Pro Ala Pro Glu Gly Lys Glu Arg Ser Lys Asn Ala 
            980                 985                 990         


Asp Gly Cys Asn 
        995     


<210>  254
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DR

<400>  254
gaactacagc cctccttaaa tggggggttc taaaac                                 36


<210>  255
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HEPN motif


<220>
<221>  misc_feature
<222>  (2)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  255

Arg Xaa Xaa Xaa Xaa His 
1               5       


<210>  256
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  N-terminal NLS

<400>  256

Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser 
1               5                   10      


<210>  257
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  N-terminal NLS

<400>  257
agccccaaga agaagagaaa ggtggaggcc agc                                    33


<210>  258
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  C-terminal NLS

<400>  258

Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala 
1               5                   10      


<210>  259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  dCas9 target

<400>  259
uuaucgucug uuuguggaug                                                   20


<210>  260
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  C-terminal NLS

<400>  260
ggacctaaga aaaagaggaa ggtggcggcc gct                                    33


<210>  261
<211>  271
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Eubacterium siraeum nCas1 array targeting ccdB

<400>  261
gaacuacacc cgugcaaaaa ugcagggguc uaaaacuaac ggcucucucu uuuauaggug       60

uaaaccgaac uacacccgug caaaaaugca ggggucuaaa accuuuaucu gacagcagac      120

gugcacuggc cagaacuaca cccgugcaaa aaugcagggg ucuaaaacca ucaugcgcca      180

gcuuucaucc ccgauaugga acuacacccg ugcaaaaaug caggggucua aaacuaaugg      240

cguuuuugau gucauuuucg cgguccgcug a                                     271


<210>  262
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Eubacterium siraeum nCas1 array targeting ccdB - full 36 nt direct repeat

<400>  262
gaacuacacc cgugcaaaaa ugcagggguc uaaaac                                 36


<210>  263
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Eubacterium siraeum nCas1 array targeting ccdB - spacer 1

<400>  263
uaacggcucu cucuuuuaua gguguaaacc                                        30


<210>  264
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Eubacterium siraeum nCas1 array targeting ccdB - spacer 2

<400>  264
cuuuaucuga cagcagacgu gcacuggcca                                        30


<210>  265
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Eubacterium siraeum nCas1 array targeting ccdB - spacer 3

<400>  265
caucaugcgc cagcuuucau ccccgauaug                                        30


<210>  266
<211>  37
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Eubacterium siraeum nCas1 array targeting ccdB - spacer 4

<400>  266
uaauggcguu uuugauguca uuuucgcggu ccgcuga                                37


<210>  267
<211>  268
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  uncultured Ruminoccus sp. nCas1 array targeting ccdB

<400>  267
cuacuacacu ggugcaaauu ugcacuaguc uaaaacuaac ggcucucucu uuuauaggug       60

uaaacccuac uacacuggug caaauuugca cuagucuaaa accuuuaucu gacagcagac      120

gugcacuggc cacuacuaca cuggugcaaa uuugcacuag ucuaaaacca ucaugcgcca      180

gcuuucaucc ccgauaugcu acuacacugg ugcaaauuug cacuagucua aaacuaaugg      240

cguuuuugau gucauuuucg cgguccgc                                         268


<210>  268
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  uncultured Ruminoccus sp. nCas1 array targeting ccdB -  full 36 nt direct repeat

<400>  268
cuacuacacu ggugcaaauu ugcacuaguc uaaaac                                 36


<210>  269
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  uncultured Ruminoccus sp. nCas1 array targeting ccdB -spacer 1

<400>  269
uaacggcucu cucuuuuaua gguguaaacc                                        30


<210>  270
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  uncultured Ruminoccus sp. nCas1 array targeting ccdB - spacer 2

<400>  270
cuuuaucuga cagcagacgu gcacuggcca                                        30


<210>  271
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  uncultured Ruminoccus sp. nCas1 array targeting ccdB - spacer 3

<400>  271
caucaugcgc cagcuuucau ccccgauaug                                        30


<210>  272
<211>  37
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  uncultured Ruminoccus sp. nCas1 array targeting ccdB -spacer 4

<400>  272
uaauggcguu uuugauguca uuuucgcggu ccgcuga                                37


<210>  273
<211>  303
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Target RNA (ccdB sequence)

<400>  273
augcaguuua agguuuacac cuauaaaaga gagagccguu aucgucuguu uguggaugua       60

cagagugaua uuauugacac gcccgggcga cggaugguga ucccccuggc cagugcacgu      120

cugcugucag auaaagucuc ccgugaacuu uacccggugg ugcauaucgg ggaugaaagc      180

uggcgcauga ugaccaccga uauggccagu gugccggucu ccguuaucgg ggaagaagug      240

gcugaucuca gccaccgcga aaaugacauc aaaaacgcca uuaaccugau guuuugggga      300

aua                                                                    303


<210>  274
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Target RNA (ccdB sequence) - spacer 1

<400>  274
gguuuacacc uauaaaagag agagccguua                                        30


<210>  275
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Target RNA (ccdB sequence) - spacer 2

<400>  275
uggccagugc acgucugcug ucagauaaag                                        30


<210>  276
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Target RNA (ccdB sequence) - spacer 3

<400>  276
cauaucgggg augaaagcug gcgcaugaug                                        30


<210>  277
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Target RNA (ccdB sequence)

<400>  277
accgcgaaaa ugacaucaaa aacgccauua                                        30


<210>  278
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Mutated Cas13d sequence, NLS-Ga_0531(trunc)-NLS-HA

<400>  278

Met Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Lys Gln Ser Lys 
1               5                   10                  15      


Lys Thr Phe Ala Lys Ala Ser Gly Leu Lys Ser Thr Leu Ala Val Asp 
            20                  25                  30          


Asn Ser Ala Val Met Thr Val Phe Gly Arg Gly Asn Glu Ala Lys Leu 
        35                  40                  45              


Asp His Arg Ile Asn Ala Asp Leu Gln Ser Glu Ser Leu His Pro Gln 
    50                  55                  60                  


Ala Ala Leu Lys Asn Val His Ala Pro Asn Lys Gln Lys Ile His Phe 
65                  70                  75                  80  


Ile Gly Arg Met Gln Asp Met Asn Leu Thr Ala Asp His Pro Leu His 
                85                  90                  95      


Ser His Asp Gly Glu Arg Ala Val Gly Ala Asp Leu Leu Cys Ala Lys 
            100                 105                 110         


Asp Lys Leu Glu Gln Leu Tyr Phe Gly Arg Thr Phe Asn Asp Asn Ile 
        115                 120                 125             


His Ile Gln Leu Ile Tyr Gln Ile Leu Asp Ile Gln Lys Ile Leu Ala 
    130                 135                 140                 


Leu His Ala Asn Asn Ile Ile Phe Ala Leu Asp Asn Leu Leu His Lys 
145                 150                 155                 160 


Lys Asn Asp Glu Leu Ser Asp Asp Phe Val Gly Met Gly Arg Met Arg 
                165                 170                 175     


Ala Thr Ile Gly Tyr Asp Ala Phe Arg Asn Ser Thr Asn Gln Lys Val 
            180                 185                 190         


Gln Glu Thr Tyr Arg Glu Phe Gln Glu Phe Val Arg Arg Lys Glu Leu 
        195                 200                 205             


Leu Tyr Phe Gly Ser Ala Phe Tyr Asn Gly Asp Thr Arg Arg Asp Glu 
    210                 215                 220                 


Lys Val Ile Tyr His Ile Leu Ser Leu Ala Ala Ser Val Arg Gln Phe 
225                 230                 235                 240 


Cys Phe His Asn Asp Tyr Thr Ser Asp Asp Gly Lys Gly Phe Ile Lys 
                245                 250                 255     


Ala Asp Trp Met Tyr Arg Leu Glu Glu Ala Leu Pro Ala Glu Tyr Lys 
            260                 265                 270         


Asp Thr Leu Asp Ala Leu Tyr Leu Glu Gly Val Glu Gly Leu Asp Gln 
        275                 280                 285             


Ser Phe Leu Lys Asn Asn Thr Val Asn Ile Gln Ile Leu Cys Ser Ile 
    290                 295                 300                 


Phe Asn His Asp Asp Pro Asn Lys Ile Ala Glu Glu Tyr Tyr Gly Phe 
305                 310                 315                 320 


Leu Met Thr Lys Glu Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys Leu 
                325                 330                 335     


Arg Glu Cys Met Leu Glu Leu Pro Glu Leu Ser Gly Tyr Lys Glu Asp 
            340                 345                 350         


Gln Tyr Asn Ser Val Arg Ser Lys Leu Tyr Lys Leu Phe Asp Phe Ile 
        355                 360                 365             


Ile Ala His Tyr Phe Arg Lys His Pro Glu Lys Gly Glu Glu Met Val 
    370                 375                 380                 


Asp Cys Leu Arg Leu Cys Met Thr Glu Asp Glu Lys Asp Ser His Tyr 
385                 390                 395                 400 


Glu Gly Thr Ala Lys Lys Leu Val Arg Glu Leu Ala Tyr Asp Met Gln 
                405                 410                 415     


Glu Ala Ala Glu Gln Ala Asn Gly Ser Asn Ile Thr Gln Met Gln Lys 
            420                 425                 430         


Asn Glu Gln Gln Gly Lys Thr Lys Gly Met Phe Ala Ile Arg Asp Glu 
        435                 440                 445             


Ile Arg Val Ser Arg Lys Pro Val Ser Tyr Phe Ser Lys Val Ile Tyr 
    450                 455                 460                 


Val Met Thr Leu Leu Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr 
465                 470                 475                 480 


Thr Leu Ile Asn Lys Phe Glu Asn Ile Val Ser Phe Glu Asp Val Leu 
                485                 490                 495     


Arg Gln Leu Asn Val Asp Cys Thr Phe Lys Pro Glu Phe Ala Phe Phe 
            500                 505                 510         


Gly Tyr Asp Arg Cys Arg Asn Ile Ser Gly Glu Leu Arg Leu Ile Asn 
        515                 520                 525             


Ser Phe Ala Arg Met Gln Lys Pro Ser Ala Lys Ala Lys His Val Met 
    530                 535                 540                 


Tyr Arg Asp Ala Leu Arg Ile Leu Gly Leu Asp Asn Gly Met Ser Glu 
545                 550                 555                 560 


Glu Ala Leu Asp Gln Glu Val Arg Arg Ile Leu Gln Ile Gly Ala Asp 
                565                 570                 575     


Gly Lys Pro Ile Lys Asn Ala Asn Lys Gly Phe Arg Asn Phe Ile Ala 
            580                 585                 590         


Ser Asn Val Ile Glu Ser Ser Arg Phe Arg Tyr Leu Val Arg Tyr Asn 
        595                 600                 605             


Asn Pro His Lys Thr Arg Met Ile Ala Gln Asn Glu Ala Ile Val Arg 
    610                 615                 620                 


Phe Val Leu Ser Glu Ile Pro Asp Glu Gln Ile Arg Arg Tyr Tyr Asp 
625                 630                 635                 640 


Val Cys Arg Asp Pro Lys Leu Pro Arg Ser Ser Ser Arg Glu Ala Gln 
                645                 650                 655     


Val Asp Ile Leu Thr Gly Ile Ile Thr Asp Val Asn Tyr Arg Ile Phe 
            660                 665                 670         


Glu Asp Val Pro Gln Ser Lys Lys Ile Asn Lys Asp Arg Pro Asp Ala 
        675                 680                 685             


Asn Asp Arg Met Thr Leu Lys Lys Gln Arg Tyr Gln Ala Ile Val Ser 
    690                 695                 700                 


Leu Tyr Leu Thr Val Met Tyr Leu Val Thr Lys Asn Leu Val Tyr Val 
705                 710                 715                 720 


Asn Ser Arg Tyr Val Met Ala Phe His Ala Leu Glu Arg Asp Ala Tyr 
                725                 730                 735     


Leu Tyr Gly Ile Thr Asn Ile Lys Gly Asp Tyr Arg Lys Leu Thr Asp 
            740                 745                 750         


Asn Leu Leu Ala Asp Glu Asn Tyr Lys Lys Phe Gly His Phe Lys Asn 
        755                 760                 765             


Lys Lys Trp Arg Gly Ile Ala Glu Gln Asn Leu Arg Asn Ser Asp Val 
    770                 775                 780                 


Pro Val Ile Lys Ser Phe Arg Asn Met Ala Ala His Ile Ser Val Ile 
785                 790                 795                 800 


Arg Asn Ile Asp Leu Tyr Ile Gly Asp Ile Gln Lys Val Asp Ser Tyr 
                805                 810                 815     


Phe Ala Leu Tyr His Phe Leu Met Gln Lys Leu Ile Gln Arg Val Val 
            820                 825                 830         


Pro Glu Asn Thr Lys Gly Leu Ser Asp Gln Thr Lys Lys Tyr Tyr Asp 
        835                 840                 845             


Ala Leu Glu Gln Tyr Asn Thr Tyr Cys Lys Asp Phe Val Lys Ala Tyr 
    850                 855                 860                 


Cys Thr Pro Phe Ala Tyr Val Thr Pro Arg Tyr Lys Asn Leu Thr Ile 
865                 870                 875                 880 


Asp Gly Leu Phe Asp Arg Asn Arg Pro Gly Glu Asp Lys Gly Ser Gly 
                885                 890                 895     


Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
            900                 905                 910         


Asp Tyr Ala 
        915 


<210>  279
<211>  919
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Mutated Cas13d sequence, NES-Ga_0531(trunc)-NES-HA

<400>  279

Met Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu Gly Ser Gly Lys 
1               5                   10                  15      


Gln Ser Lys Lys Thr Phe Ala Lys Ala Ser Gly Leu Lys Ser Thr Leu 
            20                  25                  30          


Ala Val Asp Asn Ser Ala Val Met Thr Val Phe Gly Arg Gly Asn Glu 
        35                  40                  45              


Ala Lys Leu Asp His Arg Ile Asn Ala Asp Leu Gln Ser Glu Ser Leu 
    50                  55                  60                  


His Pro Gln Ala Ala Leu Lys Asn Val His Ala Pro Asn Lys Gln Lys 
65                  70                  75                  80  


Ile His Phe Ile Gly Arg Met Gln Asp Met Asn Leu Thr Ala Asp His 
                85                  90                  95      


Pro Leu His Ser His Asp Gly Glu Arg Ala Val Gly Ala Asp Leu Leu 
            100                 105                 110         


Cys Ala Lys Asp Lys Leu Glu Gln Leu Tyr Phe Gly Arg Thr Phe Asn 
        115                 120                 125             


Asp Asn Ile His Ile Gln Leu Ile Tyr Gln Ile Leu Asp Ile Gln Lys 
    130                 135                 140                 


Ile Leu Ala Leu His Ala Asn Asn Ile Ile Phe Ala Leu Asp Asn Leu 
145                 150                 155                 160 


Leu His Lys Lys Asn Asp Glu Leu Ser Asp Asp Phe Val Gly Met Gly 
                165                 170                 175     


Arg Met Arg Ala Thr Ile Gly Tyr Asp Ala Phe Arg Asn Ser Thr Asn 
            180                 185                 190         


Gln Lys Val Gln Glu Thr Tyr Arg Glu Phe Gln Glu Phe Val Arg Arg 
        195                 200                 205             


Lys Glu Leu Leu Tyr Phe Gly Ser Ala Phe Tyr Asn Gly Asp Thr Arg 
    210                 215                 220                 


Arg Asp Glu Lys Val Ile Tyr His Ile Leu Ser Leu Ala Ala Ser Val 
225                 230                 235                 240 


Arg Gln Phe Cys Phe His Asn Asp Tyr Thr Ser Asp Asp Gly Lys Gly 
                245                 250                 255     


Phe Ile Lys Ala Asp Trp Met Tyr Arg Leu Glu Glu Ala Leu Pro Ala 
            260                 265                 270         


Glu Tyr Lys Asp Thr Leu Asp Ala Leu Tyr Leu Glu Gly Val Glu Gly 
        275                 280                 285             


Leu Asp Gln Ser Phe Leu Lys Asn Asn Thr Val Asn Ile Gln Ile Leu 
    290                 295                 300                 


Cys Ser Ile Phe Asn His Asp Asp Pro Asn Lys Ile Ala Glu Glu Tyr 
305                 310                 315                 320 


Tyr Gly Phe Leu Met Thr Lys Glu Tyr Lys Asn Met Gly Phe Ser Ile 
                325                 330                 335     


Lys Lys Leu Arg Glu Cys Met Leu Glu Leu Pro Glu Leu Ser Gly Tyr 
            340                 345                 350         


Lys Glu Asp Gln Tyr Asn Ser Val Arg Ser Lys Leu Tyr Lys Leu Phe 
        355                 360                 365             


Asp Phe Ile Ile Ala His Tyr Phe Arg Lys His Pro Glu Lys Gly Glu 
    370                 375                 380                 


Glu Met Val Asp Cys Leu Arg Leu Cys Met Thr Glu Asp Glu Lys Asp 
385                 390                 395                 400 


Ser His Tyr Glu Gly Thr Ala Lys Lys Leu Val Arg Glu Leu Ala Tyr 
                405                 410                 415     


Asp Met Gln Glu Ala Ala Glu Gln Ala Asn Gly Ser Asn Ile Thr Gln 
            420                 425                 430         


Met Gln Lys Asn Glu Gln Gln Gly Lys Thr Lys Gly Met Phe Ala Ile 
        435                 440                 445             


Arg Asp Glu Ile Arg Val Ser Arg Lys Pro Val Ser Tyr Phe Ser Lys 
    450                 455                 460                 


Val Ile Tyr Val Met Thr Leu Leu Leu Asp Gly Lys Glu Ile Asn Asp 
465                 470                 475                 480 


Leu Leu Thr Thr Leu Ile Asn Lys Phe Glu Asn Ile Val Ser Phe Glu 
                485                 490                 495     


Asp Val Leu Arg Gln Leu Asn Val Asp Cys Thr Phe Lys Pro Glu Phe 
            500                 505                 510         


Ala Phe Phe Gly Tyr Asp Arg Cys Arg Asn Ile Ser Gly Glu Leu Arg 
        515                 520                 525             


Leu Ile Asn Ser Phe Ala Arg Met Gln Lys Pro Ser Ala Lys Ala Lys 
    530                 535                 540                 


His Val Met Tyr Arg Asp Ala Leu Arg Ile Leu Gly Leu Asp Asn Gly 
545                 550                 555                 560 


Met Ser Glu Glu Ala Leu Asp Gln Glu Val Arg Arg Ile Leu Gln Ile 
                565                 570                 575     


Gly Ala Asp Gly Lys Pro Ile Lys Asn Ala Asn Lys Gly Phe Arg Asn 
            580                 585                 590         


Phe Ile Ala Ser Asn Val Ile Glu Ser Ser Arg Phe Arg Tyr Leu Val 
        595                 600                 605             


Arg Tyr Asn Asn Pro His Lys Thr Arg Met Ile Ala Gln Asn Glu Ala 
    610                 615                 620                 


Ile Val Arg Phe Val Leu Ser Glu Ile Pro Asp Glu Gln Ile Arg Arg 
625                 630                 635                 640 


Tyr Tyr Asp Val Cys Arg Asp Pro Lys Leu Pro Arg Ser Ser Ser Arg 
                645                 650                 655     


Glu Ala Gln Val Asp Ile Leu Thr Gly Ile Ile Thr Asp Val Asn Tyr 
            660                 665                 670         


Arg Ile Phe Glu Asp Val Pro Gln Ser Lys Lys Ile Asn Lys Asp Arg 
        675                 680                 685             


Pro Asp Ala Asn Asp Arg Met Thr Leu Lys Lys Gln Arg Tyr Gln Ala 
    690                 695                 700                 


Ile Val Ser Leu Tyr Leu Thr Val Met Tyr Leu Val Thr Lys Asn Leu 
705                 710                 715                 720 


Val Tyr Val Asn Ser Arg Tyr Val Met Ala Phe His Ala Leu Glu Arg 
                725                 730                 735     


Asp Ala Tyr Leu Tyr Gly Ile Thr Asn Ile Lys Gly Asp Tyr Arg Lys 
            740                 745                 750         


Leu Thr Asp Asn Leu Leu Ala Asp Glu Asn Tyr Lys Lys Phe Gly His 
        755                 760                 765             


Phe Lys Asn Lys Lys Trp Arg Gly Ile Ala Glu Gln Asn Leu Arg Asn 
    770                 775                 780                 


Ser Asp Val Pro Val Ile Lys Ser Phe Arg Asn Met Ala Ala His Ile 
785                 790                 795                 800 


Ser Val Ile Arg Asn Ile Asp Leu Tyr Ile Gly Asp Ile Gln Lys Val 
                805                 810                 815     


Asp Ser Tyr Phe Ala Leu Tyr His Phe Leu Met Gln Lys Leu Ile Gln 
            820                 825                 830         


Arg Val Val Pro Glu Asn Thr Lys Gly Leu Ser Asp Gln Thr Lys Lys 
        835                 840                 845             


Tyr Tyr Asp Ala Leu Glu Gln Tyr Asn Thr Tyr Cys Lys Asp Phe Val 
    850                 855                 860                 


Lys Ala Tyr Cys Thr Pro Phe Ala Tyr Val Thr Pro Arg Tyr Lys Asn 
865                 870                 875                 880 


Leu Thr Ile Asp Gly Leu Phe Asp Arg Asn Arg Pro Gly Glu Asp Lys 
                885                 890                 895     


Gly Ser Gly Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu Tyr Pro 
            900                 905                 910         


Tyr Asp Val Pro Asp Tyr Ala 
        915                 


<210>  280
<211>  1000
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Mutated Cas13d sequence, NLS-RfxCas13d-NLS-HA

<400>  280

Met Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ile Glu Lys Lys 
1               5                   10                  15      


Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser Thr Leu Val Ser Gly 
            20                  25                  30          


Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly Ser Asp Ala Arg Leu 
        35                  40                  45              


Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser Val Asn Glu Gly Glu 
    50                  55                  60                  


Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala Gly Tyr Lys Ile Gly 
65                  70                  75                  80  


Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala Val Val Ala Asn Asn 
                85                  90                  95      


Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met Leu Gly Leu Lys Glu 
            100                 105                 110         


Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala Asp Gly Asn Asp Asn 
        115                 120                 125             


Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp Ile Glu Lys Ile Leu 
    130                 135                 140                 


Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val Asn Asn Ile Ser Gly 
145                 150                 155                 160 


Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe Ser Thr Val Tyr Thr 
                165                 170                 175     


Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg Ala Ala Phe Asn Asn 
            180                 185                 190         


Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln Tyr Asp Glu Phe Asp 
        195                 200                 205             


Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe Gly Gln Ala Phe Phe 
    210                 215                 220                 


Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr Gly Asn Glu Cys Tyr 
225                 230                 235                 240 


Asp Ile Leu Ala Leu Leu Ser Gly Leu Arg His Trp Val Val His Asn 
                245                 250                 255     


Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp Leu Tyr Asn Leu Asp 
            260                 265                 270         


Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu Asn Tyr Leu Tyr Asp 
        275                 280                 285             


Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser Lys Asn Ser Ala Ala 
    290                 295                 300                 


Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile Asn Pro Ala Glu Phe 
305                 310                 315                 320 


Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu Gln Lys Asn Leu 
                325                 330                 335     


Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met Leu Asp Arg Lys Asp 
            340                 345                 350         


Met Ser Glu Ile Arg Lys Asn His Lys Val Phe Asp Ser Ile Arg Thr 
        355                 360                 365             


Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr Arg Tyr Tyr Ile Glu 
    370                 375                 380                 


Glu Asp Ala Lys Val Ala Ala Ala Asn Lys Ser Leu Pro Asp Asn Glu 
385                 390                 395                 400 


Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile Asn Leu Arg Gly Ser 
                405                 410                 415     


Phe Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr Asp Glu Ala Asn Arg 
            420                 425                 430         


Ile Trp Arg Lys Leu Glu Asn Ile Met His Asn Ile Lys Glu Phe Arg 
        435                 440                 445             


Gly Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp Ala Pro Arg Leu Pro 
    450                 455                 460                 


Arg Ile Leu Pro Ala Gly Arg Asp Val Ser Ala Phe Ser Lys Leu Met 
465                 470                 475                 480 


Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu 
                485                 490                 495     


Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln Ser Phe Leu Lys Val 
            500                 505                 510         


Met Pro Leu Ile Gly Val Asn Ala Lys Phe Val Glu Glu Tyr Ala Phe 
        515                 520                 525             


Phe Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu Arg Leu Ile Lys Ser 
    530                 535                 540                 


Phe Ala Arg Met Gly Glu Pro Ile Ala Asp Ala Arg Arg Ala Met Tyr 
545                 550                 555                 560 


Ile Asp Ala Ile Arg Ile Leu Gly Thr Asn Leu Ser Tyr Asp Glu Leu 
                565                 570                 575     


Lys Ala Leu Ala Asp Thr Phe Ser Leu Asp Glu Asn Gly Asn Lys Leu 
            580                 585                 590         


Lys Lys Gly Lys His Gly Met Arg Asn Phe Ile Ile Asn Asn Val Ile 
        595                 600                 605             


Ser Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr Gly Asp Pro Ala His 
    610                 615                 620                 


Leu His Glu Ile Ala Lys Asn Glu Ala Val Val Lys Phe Val Leu Gly 
625                 630                 635                 640 


Arg Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln Asn Gly Lys Asn Gln 
                645                 650                 655     


Ile Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys Asp Lys Gly Lys Ser 
            660                 665                 670         


Val Ser Glu Lys Val Asp Ala Leu Thr Lys Ile Ile Thr Gly Met Asn 
        675                 680                 685             


Tyr Asp Gln Phe Asp Lys Lys Arg Ser Val Ile Glu Asp Thr Gly Arg 
    690                 695                 700                 


Glu Asn Ala Glu Arg Glu Lys Phe Lys Lys Ile Ile Ser Leu Tyr Leu 
705                 710                 715                 720 


Thr Val Ile Tyr His Ile Leu Lys Asn Ile Val Asn Ile Asn Ala Arg 
                725                 730                 735     


Tyr Val Ile Gly Phe His Cys Val Glu Arg Asp Ala Gln Leu Tyr Lys 
            740                 745                 750         


Glu Lys Gly Tyr Asp Ile Asn Leu Lys Lys Leu Glu Glu Lys Gly Phe 
        755                 760                 765             


Ser Ser Val Thr Lys Leu Cys Ala Gly Ile Asp Glu Thr Ala Pro Asp 
    770                 775                 780                 


Lys Arg Lys Asp Val Glu Lys Glu Met Ala Glu Arg Ala Lys Glu Ser 
785                 790                 795                 800 


Ile Asp Ser Leu Glu Ser Ala Asn Pro Lys Leu Tyr Ala Asn Tyr Ile 
                805                 810                 815     


Lys Tyr Ser Asp Glu Lys Lys Ala Glu Glu Phe Thr Arg Gln Ile Asn 
            820                 825                 830         


Arg Glu Lys Ala Lys Thr Ala Leu Asn Ala Tyr Leu Arg Asn Thr Lys 
        835                 840                 845             


Trp Asn Val Ile Ile Arg Glu Asp Leu Leu Arg Ile Asp Asn Lys Thr 
    850                 855                 860                 


Cys Thr Leu Phe Arg Asn Lys Ala Val His Leu Glu Val Ala Arg Tyr 
865                 870                 875                 880 


Val His Ala Tyr Ile Asn Asp Ile Ala Glu Val Asn Ser Tyr Phe Gln 
                885                 890                 895     


Leu Tyr His Tyr Ile Met Gln Arg Ile Ile Met Asn Glu Arg Tyr Glu 
            900                 905                 910         


Lys Ser Ser Gly Lys Val Ser Glu Tyr Phe Asp Ala Val Asn Asp Glu 
        915                 920                 925             


Lys Lys Tyr Asn Asp Arg Leu Leu Lys Leu Leu Cys Val Pro Phe Gly 
    930                 935                 940                 


Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Ala Leu Phe Asp 
945                 950                 955                 960 


Arg Asn Glu Ala Ala Lys Phe Asp Lys Glu Lys Lys Lys Val Ser Gly 
                965                 970                 975     


Asn Ser Gly Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Tyr 
            980                 985                 990         


Pro Tyr Asp Val Pro Asp Tyr Ala  
        995                 1000 


<210>  281
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Mutated Cas13d sequence, NLS-RfxCas13d(del5)-NLS-HA

<400>  281

Met Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ile Glu Lys Lys 
1               5                   10                  15      


Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser Thr Leu Val Ser Gly 
            20                  25                  30          


Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly Ser Asp Ala Arg Leu 
        35                  40                  45              


Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser Val Asn Glu Gly Glu 
    50                  55                  60                  


Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala Gly Tyr Lys Ile Gly 
65                  70                  75                  80  


Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala Val Val Ala Asn Asn 
                85                  90                  95      


Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met Leu Gly Leu Lys Glu 
            100                 105                 110         


Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala Asp Gly Asn Asp Asn 
        115                 120                 125             


Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp Ile Glu Lys Ile Leu 
    130                 135                 140                 


Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val Asn Asn Ile Ser Gly 
145                 150                 155                 160 


Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe Ser Thr Val Tyr Thr 
                165                 170                 175     


Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg Ala Ala Phe Asn Asn 
            180                 185                 190         


Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln Tyr Asp Glu Phe Asp 
        195                 200                 205             


Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe Gly Gln Ala Phe Phe 
    210                 215                 220                 


Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr Gly Asn Glu Cys Tyr 
225                 230                 235                 240 


Asp Ile Leu Ala Leu Leu Ser Gly Leu Arg His Trp Val Val His Asn 
                245                 250                 255     


Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp Leu Tyr Asn Leu Asp 
            260                 265                 270         


Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu Asn Tyr Leu Tyr Asp 
        275                 280                 285             


Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser Lys Asn Ser Ala Ala 
    290                 295                 300                 


Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile Asn Pro Ala Glu Phe 
305                 310                 315                 320 


Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu Gln Lys Asn Leu 
                325                 330                 335     


Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met Leu Asp Arg Lys Asp 
            340                 345                 350         


Met Ser Glu Ile Arg Lys Asn His Lys Val Phe Asp Ser Ile Arg Thr 
        355                 360                 365             


Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr Arg Tyr Tyr Ile Glu 
    370                 375                 380                 


Glu Asp Ala Lys Val Ala Ala Ala Asn Lys Ser Leu Pro Asp Asn Glu 
385                 390                 395                 400 


Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile Asn Leu Arg Gly Ser 
                405                 410                 415     


Phe Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr Asp Glu Ala Asn Arg 
            420                 425                 430         


Ile Trp Arg Lys Leu Glu Asn Ile Met His Asn Ile Lys Glu Phe Arg 
        435                 440                 445             


Gly Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp Ala Pro Arg Leu Pro 
    450                 455                 460                 


Arg Ile Leu Pro Ala Gly Arg Asp Val Ser Ala Phe Ser Lys Leu Met 
465                 470                 475                 480 


Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu 
                485                 490                 495     


Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln Ser Phe Leu Lys Val 
            500                 505                 510         


Met Pro Leu Ile Gly Val Asn Ala Lys Phe Val Glu Glu Tyr Ala Phe 
        515                 520                 525             


Phe Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu Arg Leu Ile Lys Ser 
    530                 535                 540                 


Phe Ala Arg Met Gly Glu Pro Ile Ala Asp Ala Arg Arg Ala Met Tyr 
545                 550                 555                 560 


Ile Asp Ala Ile Arg Ile Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Met Arg Asn Phe Ile Ile Asn Asn Val Ile Ser Asn Lys Arg 
            580                 585                 590         


Phe His Tyr Leu Ile Arg Tyr Gly Asp Pro Ala His Leu His Glu Ile 
        595                 600                 605             


Ala Lys Asn Glu Ala Val Val Lys Phe Val Leu Gly Arg Ile Ala Asp 
    610                 615                 620                 


Ile Gln Lys Lys Gln Gly Gln Asn Gly Lys Asn Gln Ile Asp Arg Tyr 
625                 630                 635                 640 


Tyr Glu Thr Cys Ile Gly Lys Asp Lys Gly Lys Ser Val Ser Glu Lys 
                645                 650                 655     


Val Asp Ala Leu Thr Lys Ile Ile Thr Gly Met Asn Tyr Asp Gln Phe 
            660                 665                 670         


Asp Lys Lys Arg Ser Val Ile Glu Asp Thr Gly Arg Glu Asn Ala Glu 
        675                 680                 685             


Arg Glu Lys Phe Lys Lys Ile Ile Ser Leu Tyr Leu Thr Val Ile Tyr 
    690                 695                 700                 


His Ile Leu Lys Asn Ile Val Asn Ile Asn Ala Arg Tyr Val Ile Gly 
705                 710                 715                 720 


Phe His Cys Val Glu Arg Asp Ala Gln Leu Tyr Lys Glu Lys Gly Tyr 
                725                 730                 735     


Asp Ile Asn Leu Lys Lys Leu Glu Glu Lys Gly Phe Ser Ser Val Thr 
            740                 745                 750         


Lys Leu Cys Ala Gly Ile Asp Glu Thr Ala Pro Asp Lys Arg Lys Asp 
        755                 760                 765             


Val Glu Lys Glu Met Ala Glu Arg Ala Lys Glu Ser Ile Asp Ser Leu 
    770                 775                 780                 


Glu Ser Ala Asn Pro Lys Leu Tyr Ala Asn Tyr Ile Lys Tyr Ser Asp 
785                 790                 795                 800 


Glu Lys Lys Ala Glu Glu Phe Thr Arg Gln Ile Asn Arg Glu Lys Ala 
                805                 810                 815     


Lys Thr Ala Leu Asn Ala Tyr Leu Arg Asn Thr Lys Trp Asn Val Ile 
            820                 825                 830         


Ile Arg Glu Asp Leu Leu Arg Ile Asp Asn Lys Thr Cys Thr Leu Phe 
        835                 840                 845             


Arg Asn Lys Ala Val His Leu Glu Val Ala Arg Tyr Val His Ala Tyr 
    850                 855                 860                 


Ile Asn Asp Ile Ala Glu Val Asn Ser Tyr Phe Gln Leu Tyr His Tyr 
865                 870                 875                 880 


Ile Met Gln Arg Ile Ile Met Asn Glu Arg Tyr Glu Lys Ser Ser Gly 
                885                 890                 895     


Lys Val Ser Glu Tyr Phe Asp Ala Val Asn Asp Glu Lys Lys Tyr Asn 
            900                 905                 910         


Asp Arg Leu Leu Lys Leu Leu Cys Val Pro Phe Gly Tyr Cys Ile Pro 
        915                 920                 925             


Arg Phe Lys Asn Leu Ser Ile Glu Ala Leu Phe Asp Arg Asn Glu Ala 
    930                 935                 940                 


Ala Lys Phe Asp Lys Glu Lys Lys Lys Val Ser Gly Asn Ser Gly Ser 
945                 950                 955                 960 


Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Tyr Pro Tyr Asp Val 
                965                 970                 975     


Pro Asp Tyr Ala 
            980 


<210>  282
<211>  965
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Mutated Cas13d sequence, NLS-RfxCas13d(del5.12)-NLS-HA

<400>  282

Met Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ile Glu Lys Lys 
1               5                   10                  15      


Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser Thr Leu Val Ser Gly 
            20                  25                  30          


Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly Ser Asp Ala Arg Leu 
        35                  40                  45              


Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser Val Asn Glu Gly Glu 
    50                  55                  60                  


Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala Gly Tyr Lys Ile Gly 
65                  70                  75                  80  


Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala Val Val Ala Asn Asn 
                85                  90                  95      


Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met Leu Gly Leu Lys Glu 
            100                 105                 110         


Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala Asp Gly Asn Asp Asn 
        115                 120                 125             


Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp Ile Glu Lys Ile Leu 
    130                 135                 140                 


Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val Asn Asn Ile Ser Gly 
145                 150                 155                 160 


Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe Ser Thr Val Tyr Thr 
                165                 170                 175     


Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg Ala Ala Phe Asn Asn 
            180                 185                 190         


Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln Tyr Asp Glu Phe Asp 
        195                 200                 205             


Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe Gly Gln Ala Phe Phe 
    210                 215                 220                 


Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr Gly Asn Glu Cys Tyr 
225                 230                 235                 240 


Asp Ile Leu Ala Leu Leu Ser Gly Leu Arg His Trp Val Val His Asn 
                245                 250                 255     


Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp Leu Tyr Asn Leu Asp 
            260                 265                 270         


Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu Asn Tyr Leu Tyr Asp 
        275                 280                 285             


Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser Lys Asn Ser Ala Ala 
    290                 295                 300                 


Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile Asn Pro Ala Glu Phe 
305                 310                 315                 320 


Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu Gln Lys Asn Leu 
                325                 330                 335     


Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met Leu Asp Arg Lys Asp 
            340                 345                 350         


Met Ser Glu Ile Arg Lys Asn His Lys Val Phe Asp Ser Ile Arg Thr 
        355                 360                 365             


Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr Arg Tyr Tyr Ile Glu 
    370                 375                 380                 


Glu Asp Ala Lys Val Ala Ala Ala Asn Lys Ser Leu Pro Asp Asn Glu 
385                 390                 395                 400 


Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile Asn Leu Arg Gly Ser 
                405                 410                 415     


Phe Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr Asp Glu Ala Asn Arg 
            420                 425                 430         


Ile Trp Arg Lys Leu Glu Asn Ile Met His Asn Ile Lys Glu Phe Arg 
        435                 440                 445             


Gly Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp Ala Pro Arg Leu Pro 
    450                 455                 460                 


Arg Ile Leu Pro Ala Gly Arg Asp Val Ser Ala Phe Ser Lys Leu Met 
465                 470                 475                 480 


Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu 
                485                 490                 495     


Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln Ser Phe Leu Lys Val 
            500                 505                 510         


Met Pro Leu Ile Gly Val Asn Ala Lys Phe Val Glu Glu Tyr Ala Phe 
        515                 520                 525             


Phe Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu Arg Leu Ile Lys Ser 
    530                 535                 540                 


Phe Ala Arg Met Gly Glu Pro Ile Ala Asp Ala Arg Arg Ala Met Tyr 
545                 550                 555                 560 


Ile Asp Ala Ile Arg Ile Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Met Arg Asn Phe Ile Ile Asn Asn Val Ile Ser Asn Lys Arg 
            580                 585                 590         


Phe His Tyr Leu Ile Arg Tyr Gly Asp Pro Ala His Leu His Glu Ile 
        595                 600                 605             


Ala Lys Asn Glu Ala Val Val Lys Phe Val Leu Gly Arg Ile Ala Asp 
    610                 615                 620                 


Ile Gln Lys Lys Gln Gly Gln Asn Gly Lys Asn Gln Ile Asp Arg Tyr 
625                 630                 635                 640 


Tyr Glu Thr Cys Ile Gly Lys Asp Lys Gly Lys Ser Val Ser Glu Lys 
                645                 650                 655     


Val Asp Ala Leu Thr Lys Ile Ile Thr Gly Met Asn Tyr Asp Gln Phe 
            660                 665                 670         


Asp Lys Lys Arg Ser Val Ile Glu Asp Thr Gly Arg Glu Asn Ala Glu 
        675                 680                 685             


Arg Glu Lys Phe Lys Lys Ile Ile Ser Leu Tyr Leu Thr Val Ile Tyr 
    690                 695                 700                 


His Ile Leu Lys Asn Ile Val Asn Ile Asn Ala Arg Tyr Val Ile Gly 
705                 710                 715                 720 


Phe His Cys Val Glu Arg Asp Ala Gln Leu Tyr Lys Glu Lys Gly Tyr 
                725                 730                 735     


Asp Ile Asn Leu Lys Lys Leu Glu Glu Lys Gly Phe Ser Ser Val Thr 
            740                 745                 750         


Lys Leu Cys Ala Gly Ile Asp Glu Thr Ala Pro Asp Lys Arg Lys Asp 
        755                 760                 765             


Val Glu Lys Glu Met Ala Glu Arg Ala Lys Glu Ser Ile Asp Ser Leu 
    770                 775                 780                 


Glu Ser Ala Asn Pro Lys Leu Tyr Ala Asn Tyr Ile Lys Tyr Ser Asp 
785                 790                 795                 800 


Glu Lys Lys Ala Glu Glu Phe Thr Arg Gln Ile Asn Arg Glu Lys Ala 
                805                 810                 815     


Lys Thr Ala Leu Asn Ala Tyr Leu Arg Asn Thr Lys Trp Asn Val Ile 
            820                 825                 830         


Ile Arg Glu Asp Leu Leu Arg Ile Asp Asn Lys Thr Cys Thr Leu Phe 
        835                 840                 845             


Arg Asn Lys Ala Val His Leu Glu Val Ala Arg Tyr Val His Ala Tyr 
    850                 855                 860                 


Ile Asn Asp Ile Ala Glu Val Asn Ser Tyr Phe Gln Leu Tyr His Tyr 
865                 870                 875                 880 


Ile Met Gln Arg Ile Ile Met Asn Glu Arg Tyr Glu Lys Ser Ser Gly 
                885                 890                 895     


Lys Val Ser Glu Tyr Phe Asp Ala Val Asn Asp Glu Lys Lys Tyr Asn 
            900                 905                 910         


Asp Arg Leu Leu Lys Leu Leu Cys Val Pro Phe Gly Tyr Cys Ile Pro 
        915                 920                 925             


Arg Phe Lys Asn Leu Ser Ile Glu Ala Leu Phe Asp Arg Asn Glu Gly 
    930                 935                 940                 


Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Tyr Pro Tyr Asp 
945                 950                 955                 960 


Val Pro Asp Tyr Ala 
                965 


<210>  283
<211>  963
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Mutated Cas13d sequence, NLS-RfxCas13d(del5.13)-NLS-HA

<400>  283

Met Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ile Glu Lys Lys 
1               5                   10                  15      


Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser Thr Leu Val Ser Gly 
            20                  25                  30          


Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly Ser Asp Ala Arg Leu 
        35                  40                  45              


Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser Val Asn Glu Gly Glu 
    50                  55                  60                  


Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala Gly Tyr Lys Ile Gly 
65                  70                  75                  80  


Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala Val Val Ala Asn Asn 
                85                  90                  95      


Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met Leu Gly Leu Lys Glu 
            100                 105                 110         


Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala Asp Gly Asn Asp Asn 
        115                 120                 125             


Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp Ile Glu Lys Ile Leu 
    130                 135                 140                 


Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val Asn Asn Ile Ser Gly 
145                 150                 155                 160 


Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe Ser Thr Val Tyr Thr 
                165                 170                 175     


Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg Ala Ala Phe Asn Asn 
            180                 185                 190         


Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln Tyr Asp Glu Phe Asp 
        195                 200                 205             


Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe Gly Gln Ala Phe Phe 
    210                 215                 220                 


Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr Gly Asn Glu Cys Tyr 
225                 230                 235                 240 


Asp Ile Leu Ala Leu Leu Ser Gly Leu Arg His Trp Val Val His Asn 
                245                 250                 255     


Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp Leu Tyr Asn Leu Asp 
            260                 265                 270         


Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu Asn Tyr Leu Tyr Asp 
        275                 280                 285             


Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser Lys Asn Ser Ala Ala 
    290                 295                 300                 


Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile Asn Pro Ala Glu Phe 
305                 310                 315                 320 


Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu Gln Lys Asn Leu 
                325                 330                 335     


Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met Leu Asp Arg Lys Asp 
            340                 345                 350         


Met Ser Glu Ile Arg Lys Asn His Lys Val Phe Asp Ser Ile Arg Thr 
        355                 360                 365             


Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr Arg Tyr Tyr Ile Glu 
    370                 375                 380                 


Glu Asp Ser Glu Lys Asp Ile Phe Val Ile Asn Leu Arg Gly Ser Phe 
385                 390                 395                 400 


Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr Asp Glu Ala Asn Arg Ile 
                405                 410                 415     


Trp Arg Lys Leu Glu Asn Ile Met His Asn Ile Lys Glu Phe Arg Gly 
            420                 425                 430         


Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp Ala Pro Arg Leu Pro Arg 
        435                 440                 445             


Ile Leu Pro Ala Gly Arg Asp Val Ser Ala Phe Ser Lys Leu Met Tyr 
    450                 455                 460                 


Ala Leu Thr Met Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr 
465                 470                 475                 480 


Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln Ser Phe Leu Lys Val Met 
                485                 490                 495     


Pro Leu Ile Gly Val Asn Ala Lys Phe Val Glu Glu Tyr Ala Phe Phe 
            500                 505                 510         


Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu Arg Leu Ile Lys Ser Phe 
        515                 520                 525             


Ala Arg Met Gly Glu Pro Ile Ala Asp Ala Arg Arg Ala Met Tyr Ile 
    530                 535                 540                 


Asp Ala Ile Arg Ile Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Met Arg Asn Phe Ile Ile Asn Asn Val Ile Ser Asn Lys Arg Phe 
                565                 570                 575     


His Tyr Leu Ile Arg Tyr Gly Asp Pro Ala His Leu His Glu Ile Ala 
            580                 585                 590         


Lys Asn Glu Ala Val Val Lys Phe Val Leu Gly Arg Ile Ala Asp Ile 
        595                 600                 605             


Gln Lys Lys Gln Gly Gln Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr 
    610                 615                 620                 


Glu Thr Cys Ile Gly Lys Asp Lys Gly Lys Ser Val Ser Glu Lys Val 
625                 630                 635                 640 


Asp Ala Leu Thr Lys Ile Ile Thr Gly Met Asn Tyr Asp Gln Phe Asp 
                645                 650                 655     


Lys Lys Arg Ser Val Ile Glu Asp Thr Gly Arg Glu Asn Ala Glu Arg 
            660                 665                 670         


Glu Lys Phe Lys Lys Ile Ile Ser Leu Tyr Leu Thr Val Ile Tyr His 
        675                 680                 685             


Ile Leu Lys Asn Ile Val Asn Ile Asn Ala Arg Tyr Val Ile Gly Phe 
    690                 695                 700                 


His Cys Val Glu Arg Asp Ala Gln Leu Tyr Lys Glu Lys Gly Tyr Asp 
705                 710                 715                 720 


Ile Asn Leu Lys Lys Leu Glu Glu Lys Gly Phe Ser Ser Val Thr Lys 
                725                 730                 735     


Leu Cys Ala Gly Ile Asp Glu Thr Ala Pro Asp Lys Arg Lys Asp Val 
            740                 745                 750         


Glu Lys Glu Met Ala Glu Arg Ala Lys Glu Ser Ile Asp Ser Leu Glu 
        755                 760                 765             


Ser Ala Asn Pro Lys Leu Tyr Ala Asn Tyr Ile Lys Tyr Ser Asp Glu 
    770                 775                 780                 


Lys Lys Ala Glu Glu Phe Thr Arg Gln Ile Asn Arg Glu Lys Ala Lys 
785                 790                 795                 800 


Thr Ala Leu Asn Ala Tyr Leu Arg Asn Thr Lys Trp Asn Val Ile Ile 
                805                 810                 815     


Arg Glu Asp Leu Leu Arg Ile Asp Asn Lys Thr Cys Thr Leu Phe Arg 
            820                 825                 830         


Asn Lys Ala Val His Leu Glu Val Ala Arg Tyr Val His Ala Tyr Ile 
        835                 840                 845             


Asn Asp Ile Ala Glu Val Asn Ser Tyr Phe Gln Leu Tyr His Tyr Ile 
    850                 855                 860                 


Met Gln Arg Ile Ile Met Asn Glu Arg Tyr Glu Lys Ser Ser Gly Lys 
865                 870                 875                 880 


Val Ser Glu Tyr Phe Asp Ala Val Asn Asp Glu Lys Lys Tyr Asn Asp 
                885                 890                 895     


Arg Leu Leu Lys Leu Leu Cys Val Pro Phe Gly Tyr Cys Ile Pro Arg 
            900                 905                 910         


Phe Lys Asn Leu Ser Ile Glu Ala Leu Phe Asp Arg Asn Glu Ala Ala 
        915                 920                 925             


Lys Phe Asp Lys Glu Lys Lys Lys Val Ser Gly Asn Ser Gly Ser Gly 
    930                 935                 940                 


Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Tyr Pro Tyr Asp Val Pro 
945                 950                 955                 960 


Asp Tyr Ala 
            


<210>  284
<211>  948
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Mutated Cas13d sequence, NLS-RfxCas13d(del5.12+5.13)-NLS-HA

<400>  284

Met Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ile Glu Lys Lys 
1               5                   10                  15      


Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser Thr Leu Val Ser Gly 
            20                  25                  30          


Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly Ser Asp Ala Arg Leu 
        35                  40                  45              


Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser Val Asn Glu Gly Glu 
    50                  55                  60                  


Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala Gly Tyr Lys Ile Gly 
65                  70                  75                  80  


Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala Val Val Ala Asn Asn 
                85                  90                  95      


Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met Leu Gly Leu Lys Glu 
            100                 105                 110         


Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala Asp Gly Asn Asp Asn 
        115                 120                 125             


Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp Ile Glu Lys Ile Leu 
    130                 135                 140                 


Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val Asn Asn Ile Ser Gly 
145                 150                 155                 160 


Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe Ser Thr Val Tyr Thr 
                165                 170                 175     


Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg Ala Ala Phe Asn Asn 
            180                 185                 190         


Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln Tyr Asp Glu Phe Asp 
        195                 200                 205             


Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe Gly Gln Ala Phe Phe 
    210                 215                 220                 


Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr Gly Asn Glu Cys Tyr 
225                 230                 235                 240 


Asp Ile Leu Ala Leu Leu Ser Gly Leu Arg His Trp Val Val His Asn 
                245                 250                 255     


Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp Leu Tyr Asn Leu Asp 
            260                 265                 270         


Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu Asn Tyr Leu Tyr Asp 
        275                 280                 285             


Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser Lys Asn Ser Ala Ala 
    290                 295                 300                 


Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile Asn Pro Ala Glu Phe 
305                 310                 315                 320 


Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu Gln Lys Asn Leu 
                325                 330                 335     


Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met Leu Asp Arg Lys Asp 
            340                 345                 350         


Met Ser Glu Ile Arg Lys Asn His Lys Val Phe Asp Ser Ile Arg Thr 
        355                 360                 365             


Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr Arg Tyr Tyr Ile Glu 
    370                 375                 380                 


Glu Asp Ser Glu Lys Asp Ile Phe Val Ile Asn Leu Arg Gly Ser Phe 
385                 390                 395                 400 


Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr Asp Glu Ala Asn Arg Ile 
                405                 410                 415     


Trp Arg Lys Leu Glu Asn Ile Met His Asn Ile Lys Glu Phe Arg Gly 
            420                 425                 430         


Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp Ala Pro Arg Leu Pro Arg 
        435                 440                 445             


Ile Leu Pro Ala Gly Arg Asp Val Ser Ala Phe Ser Lys Leu Met Tyr 
    450                 455                 460                 


Ala Leu Thr Met Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr 
465                 470                 475                 480 


Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln Ser Phe Leu Lys Val Met 
                485                 490                 495     


Pro Leu Ile Gly Val Asn Ala Lys Phe Val Glu Glu Tyr Ala Phe Phe 
            500                 505                 510         


Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu Arg Leu Ile Lys Ser Phe 
        515                 520                 525             


Ala Arg Met Gly Glu Pro Ile Ala Asp Ala Arg Arg Ala Met Tyr Ile 
    530                 535                 540                 


Asp Ala Ile Arg Ile Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Met Arg Asn Phe Ile Ile Asn Asn Val Ile Ser Asn Lys Arg Phe 
                565                 570                 575     


His Tyr Leu Ile Arg Tyr Gly Asp Pro Ala His Leu His Glu Ile Ala 
            580                 585                 590         


Lys Asn Glu Ala Val Val Lys Phe Val Leu Gly Arg Ile Ala Asp Ile 
        595                 600                 605             


Gln Lys Lys Gln Gly Gln Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr 
    610                 615                 620                 


Glu Thr Cys Ile Gly Lys Asp Lys Gly Lys Ser Val Ser Glu Lys Val 
625                 630                 635                 640 


Asp Ala Leu Thr Lys Ile Ile Thr Gly Met Asn Tyr Asp Gln Phe Asp 
                645                 650                 655     


Lys Lys Arg Ser Val Ile Glu Asp Thr Gly Arg Glu Asn Ala Glu Arg 
            660                 665                 670         


Glu Lys Phe Lys Lys Ile Ile Ser Leu Tyr Leu Thr Val Ile Tyr His 
        675                 680                 685             


Ile Leu Lys Asn Ile Val Asn Ile Asn Ala Arg Tyr Val Ile Gly Phe 
    690                 695                 700                 


His Cys Val Glu Arg Asp Ala Gln Leu Tyr Lys Glu Lys Gly Tyr Asp 
705                 710                 715                 720 


Ile Asn Leu Lys Lys Leu Glu Glu Lys Gly Phe Ser Ser Val Thr Lys 
                725                 730                 735     


Leu Cys Ala Gly Ile Asp Glu Thr Ala Pro Asp Lys Arg Lys Asp Val 
            740                 745                 750         


Glu Lys Glu Met Ala Glu Arg Ala Lys Glu Ser Ile Asp Ser Leu Glu 
        755                 760                 765             


Ser Ala Asn Pro Lys Leu Tyr Ala Asn Tyr Ile Lys Tyr Ser Asp Glu 
    770                 775                 780                 


Lys Lys Ala Glu Glu Phe Thr Arg Gln Ile Asn Arg Glu Lys Ala Lys 
785                 790                 795                 800 


Thr Ala Leu Asn Ala Tyr Leu Arg Asn Thr Lys Trp Asn Val Ile Ile 
                805                 810                 815     


Arg Glu Asp Leu Leu Arg Ile Asp Asn Lys Thr Cys Thr Leu Phe Arg 
            820                 825                 830         


Asn Lys Ala Val His Leu Glu Val Ala Arg Tyr Val His Ala Tyr Ile 
        835                 840                 845             


Asn Asp Ile Ala Glu Val Asn Ser Tyr Phe Gln Leu Tyr His Tyr Ile 
    850                 855                 860                 


Met Gln Arg Ile Ile Met Asn Glu Arg Tyr Glu Lys Ser Ser Gly Lys 
865                 870                 875                 880 


Val Ser Glu Tyr Phe Asp Ala Val Asn Asp Glu Lys Lys Tyr Asn Asp 
                885                 890                 895     


Arg Leu Leu Lys Leu Leu Cys Val Pro Phe Gly Tyr Cys Ile Pro Arg 
            900                 905                 910         


Phe Lys Asn Leu Ser Ile Glu Ala Leu Phe Asp Arg Asn Glu Gly Ser 
        915                 920                 925             


Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Tyr Pro Tyr Asp Val 
    930                 935                 940                 


Pro Asp Tyr Ala 
945             


<210>  285
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Mutated Cas13d sequence, NLS-RfxCas13d(del13)-NLS-HA

<400>  285

Met Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ile Glu Lys Lys 
1               5                   10                  15      


Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser Thr Leu Val Ser Gly 
            20                  25                  30          


Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly Ser Asp Ala Arg Leu 
        35                  40                  45              


Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser Val Asn Glu Gly Glu 
    50                  55                  60                  


Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala Gly Tyr Lys Ile Gly 
65                  70                  75                  80  


Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala Val Val Ala Asn Asn 
                85                  90                  95      


Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met Leu Gly Leu Lys Glu 
            100                 105                 110         


Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala Asp Gly Asn Asp Asn 
        115                 120                 125             


Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp Ile Glu Lys Ile Leu 
    130                 135                 140                 


Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val Asn Asn Ile Ser Gly 
145                 150                 155                 160 


Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe Ser Thr Val Tyr Thr 
                165                 170                 175     


Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg Ala Ala Phe Asn Asn 
            180                 185                 190         


Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln Tyr Asp Glu Phe Asp 
        195                 200                 205             


Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe Gly Gln Ala Phe Phe 
    210                 215                 220                 


Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr Gly Asn Glu Cys Tyr 
225                 230                 235                 240 


Asp Ile Leu Ala Leu Leu Ser Gly Leu Arg His Trp Val Val His Asn 
                245                 250                 255     


Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp Leu Tyr Asn Leu Asp 
            260                 265                 270         


Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu Asn Tyr Leu Tyr Asp 
        275                 280                 285             


Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser Lys Asn Ser Ala Ala 
    290                 295                 300                 


Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile Asn Pro Ala Glu Phe 
305                 310                 315                 320 


Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu Gln Lys Asn Leu 
                325                 330                 335     


Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met Leu Asp Arg Lys Asp 
            340                 345                 350         


Met Ser Glu Ile Arg Lys Asn His Lys Val Phe Asp Ser Ile Arg Thr 
        355                 360                 365             


Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr Arg Tyr Tyr Ile Glu 
    370                 375                 380                 


Glu Asp Ser Glu Lys Asp Ile Phe Val Ile Asn Leu Arg Gly Ser Phe 
385                 390                 395                 400 


Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr Asp Glu Ala Asn Arg Ile 
                405                 410                 415     


Trp Arg Lys Leu Glu Asn Ile Met His Asn Ile Lys Glu Phe Arg Gly 
            420                 425                 430         


Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp Ala Pro Arg Leu Pro Arg 
        435                 440                 445             


Ile Leu Pro Ala Gly Arg Asp Val Ser Ala Phe Ser Lys Leu Met Tyr 
    450                 455                 460                 


Ala Leu Thr Met Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr 
465                 470                 475                 480 


Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln Ser Phe Leu Lys Val Met 
                485                 490                 495     


Pro Leu Ile Gly Val Asn Ala Lys Phe Val Glu Glu Tyr Ala Phe Phe 
            500                 505                 510         


Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu Arg Leu Ile Lys Ser Phe 
        515                 520                 525             


Ala Arg Met Gly Glu Pro Ile Ala Asp Ala Arg Arg Ala Met Tyr Ile 
    530                 535                 540                 


Asp Ala Ile Arg Ile Leu Gly Thr Asn Leu Ser Tyr Asp Glu Leu Lys 
545                 550                 555                 560 


Ala Leu Ala Asp Thr Phe Ser Leu Asp Glu Asn Gly Asn Lys Leu Lys 
                565                 570                 575     


Lys Gly Lys His Gly Met Arg Asn Phe Ile Ile Asn Asn Val Ile Ser 
            580                 585                 590         


Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr Gly Asp Pro Ala His Leu 
        595                 600                 605             


His Glu Ile Ala Lys Asn Glu Ala Val Val Lys Phe Val Leu Gly Arg 
    610                 615                 620                 


Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln Asn Gly Lys Asn Gln Ile 
625                 630                 635                 640 


Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys Asp Lys Gly Lys Ser Val 
                645                 650                 655     


Ser Glu Lys Val Asp Ala Leu Thr Lys Ile Ile Thr Gly Met Asn Tyr 
            660                 665                 670         


Asp Gln Phe Asp Lys Lys Arg Ser Val Ile Glu Asp Thr Gly Arg Glu 
        675                 680                 685             


Asn Ala Glu Arg Glu Lys Phe Lys Lys Ile Ile Ser Leu Tyr Leu Thr 
    690                 695                 700                 


Val Ile Tyr His Ile Leu Lys Asn Ile Val Asn Ile Asn Ala Arg Tyr 
705                 710                 715                 720 


Val Ile Gly Phe His Cys Val Glu Arg Asp Ala Gln Leu Tyr Lys Glu 
                725                 730                 735     


Lys Gly Tyr Asp Ile Asn Leu Lys Lys Leu Glu Glu Lys Gly Phe Ser 
            740                 745                 750         


Ser Val Thr Lys Leu Cys Ala Gly Ile Asp Glu Thr Ala Pro Asp Lys 
        755                 760                 765             


Arg Lys Asp Val Glu Lys Glu Met Ala Glu Arg Ala Lys Glu Ser Ile 
    770                 775                 780                 


Asp Ser Leu Glu Ser Ala Asn Pro Lys Leu Tyr Ala Asn Tyr Ile Lys 
785                 790                 795                 800 


Tyr Ser Asp Glu Lys Lys Ala Glu Glu Phe Thr Arg Gln Ile Asn Arg 
                805                 810                 815     


Glu Lys Ala Lys Thr Ala Leu Asn Ala Tyr Leu Arg Asn Thr Lys Trp 
            820                 825                 830         


Asn Val Ile Ile Arg Glu Asp Leu Leu Arg Ile Asp Asn Lys Thr Cys 
        835                 840                 845             


Thr Leu Phe Arg Asn Lys Ala Val His Leu Glu Val Ala Arg Tyr Val 
    850                 855                 860                 


His Ala Tyr Ile Asn Asp Ile Ala Glu Val Asn Ser Tyr Phe Gln Leu 
865                 870                 875                 880 


Tyr His Tyr Ile Met Gln Arg Ile Ile Met Asn Glu Arg Tyr Glu Lys 
                885                 890                 895     


Ser Ser Gly Lys Val Ser Glu Tyr Phe Asp Ala Val Asn Asp Glu Lys 
            900                 905                 910         


Lys Tyr Asn Asp Arg Leu Leu Lys Leu Leu Cys Val Pro Phe Gly Tyr 
        915                 920                 925             


Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Ala Leu Phe Asp Arg 
    930                 935                 940                 


Asn Glu Ala Ala Lys Phe Asp Lys Glu Lys Lys Lys Val Ser Gly Asn 
945                 950                 955                 960 


Ser Gly Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Tyr Pro 
                965                 970                 975     


Tyr Asp Val Pro Asp Tyr Ala 
            980             


<210>  286
<211>  1378
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Effector sequence used to edit ADAR2 expression

<400>  286

Met Ile Glu Lys Lys Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser 
1               5                   10                  15      


Thr Leu Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly 
            20                  25                  30          


Ser Asp Ala Arg Leu Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser 
        35                  40                  45              


Val Asn Glu Gly Glu Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala 
    50                  55                  60                  


Gly Tyr Lys Ile Gly Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala 
65                  70                  75                  80  


Val Val Ala Asn Asn Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met 
                85                  90                  95      


Leu Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala 
            100                 105                 110         


Asp Gly Asn Asp Asn Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp 
        115                 120                 125             


Ile Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val 
    130                 135                 140                 


Asn Asn Ile Ser Gly Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe 
145                 150                 155                 160 


Ser Thr Val Tyr Thr Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg 
                165                 170                 175     


Ala Ala Phe Asn Asn Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln 
            180                 185                 190         


Tyr Asp Glu Phe Asp Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe 
        195                 200                 205             


Gly Gln Ala Phe Phe Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr 
    210                 215                 220                 


Gly Asn Glu Cys Tyr Asp Ile Leu Ala Leu Leu Ser Gly Leu Arg His 
225                 230                 235                 240 


Trp Val Val His Asn Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp 
                245                 250                 255     


Leu Tyr Asn Leu Asp Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu 
            260                 265                 270         


Asn Tyr Leu Tyr Asp Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser 
        275                 280                 285             


Lys Asn Ser Ala Ala Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile 
    290                 295                 300                 


Asn Pro Ala Glu Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys 
305                 310                 315                 320 


Glu Gln Lys Asn Leu Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met 
                325                 330                 335     


Leu Asp Arg Lys Asp Met Ser Glu Ile Arg Lys Asn His Lys Val Phe 
            340                 345                 350         


Asp Ser Ile Arg Thr Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr 
        355                 360                 365             


Arg Tyr Tyr Ile Glu Glu Asp Ala Lys Val Ala Ala Ala Asn Lys Ser 
    370                 375                 380                 


Leu Pro Asp Asn Glu Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile 
385                 390                 395                 400 


Asn Leu Arg Gly Ser Phe Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr 
                405                 410                 415     


Asp Glu Ala Asn Arg Ile Trp Arg Lys Leu Glu Asn Ile Met His Asn 
            420                 425                 430         


Ile Lys Glu Phe Arg Gly Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp 
        435                 440                 445             


Ala Pro Arg Leu Pro Arg Ile Leu Pro Ala Gly Arg Asp Val Ser Ala 
    450                 455                 460                 


Phe Ser Lys Leu Met Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu 
465                 470                 475                 480 


Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln 
                485                 490                 495     


Ser Phe Leu Lys Val Met Pro Leu Ile Gly Val Asn Ala Lys Phe Val 
            500                 505                 510         


Glu Glu Tyr Ala Phe Phe Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu 
        515                 520                 525             


Arg Leu Ile Lys Ser Phe Ala Arg Met Gly Glu Pro Ile Ala Asp Ala 
    530                 535                 540                 


Arg Arg Ala Met Tyr Ile Asp Ala Ile Arg Ile Leu Gly Thr Asn Leu 
545                 550                 555                 560 


Ser Tyr Asp Glu Leu Lys Ala Leu Ala Asp Thr Phe Ser Leu Asp Glu 
                565                 570                 575     


Asn Gly Asn Lys Leu Lys Lys Gly Lys His Gly Met Arg Asn Phe Ile 
            580                 585                 590         


Ile Asn Asn Val Ile Ser Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr 
        595                 600                 605             


Gly Asp Pro Ala His Leu His Glu Ile Ala Lys Asn Glu Ala Val Val 
    610                 615                 620                 


Lys Phe Val Leu Gly Arg Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln 
625                 630                 635                 640 


Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys 
                645                 650                 655     


Asp Lys Gly Lys Ser Val Ser Glu Lys Val Asp Ala Leu Thr Lys Ile 
            660                 665                 670         


Ile Thr Gly Met Asn Tyr Asp Gln Phe Asp Lys Lys Arg Ser Val Ile 
        675                 680                 685             


Glu Asp Thr Gly Arg Glu Asn Ala Glu Arg Glu Lys Phe Lys Lys Ile 
    690                 695                 700                 


Ile Ser Leu Tyr Leu Thr Val Ile Tyr His Ile Leu Lys Asn Ile Val 
705                 710                 715                 720 


Asn Ile Asn Ala Arg Tyr Val Ile Gly Phe His Cys Val Glu Arg Asp 
                725                 730                 735     


Ala Gln Leu Tyr Lys Glu Lys Gly Tyr Asp Ile Asn Leu Lys Lys Leu 
            740                 745                 750         


Glu Glu Lys Gly Phe Ser Ser Val Thr Lys Leu Cys Ala Gly Ile Asp 
        755                 760                 765             


Glu Thr Ala Pro Asp Lys Arg Lys Asp Val Glu Lys Glu Met Ala Glu 
    770                 775                 780                 


Arg Ala Lys Glu Ser Ile Asp Ser Leu Glu Ser Ala Asn Pro Lys Leu 
785                 790                 795                 800 


Tyr Ala Asn Tyr Ile Lys Tyr Ser Asp Glu Lys Lys Ala Glu Glu Phe 
                805                 810                 815     


Thr Arg Gln Ile Asn Arg Glu Lys Ala Lys Thr Ala Leu Asn Ala Tyr 
            820                 825                 830         


Leu Arg Asn Thr Lys Trp Asn Val Ile Ile Arg Glu Asp Leu Leu Arg 
        835                 840                 845             


Ile Asp Asn Lys Thr Cys Thr Leu Phe Arg Asn Lys Ala Val Ala Leu 
    850                 855                 860                 


Glu Val Ala Arg Tyr Val His Ala Tyr Ile Asn Asp Ile Ala Glu Val 
865                 870                 875                 880 


Asn Ser Tyr Phe Gln Leu Tyr His Tyr Ile Met Gln Arg Ile Ile Met 
                885                 890                 895     


Asn Glu Arg Tyr Glu Lys Ser Ser Gly Lys Val Ser Glu Tyr Phe Asp 
            900                 905                 910         


Ala Val Asn Asp Glu Lys Lys Tyr Asn Asp Arg Leu Leu Lys Leu Leu 
        915                 920                 925             


Cys Val Pro Phe Gly Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile 
    930                 935                 940                 


Glu Ala Leu Phe Asp Arg Asn Glu Ala Ala Lys Phe Asp Lys Glu Lys 
945                 950                 955                 960 


Lys Lys Val Ser Gly Asn Ser Ser Arg Gly Ser Gly Pro Lys Lys Lys 
                965                 970                 975     


Arg Lys Val Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly 
            980                 985                 990         


Ser Gln Leu His Leu Pro Gln Val  Leu Ala Asp Ala Val  Ser Arg Leu 
        995                 1000                 1005             


Val Leu  Gly Lys Phe Gly Asp  Leu Thr Asp Asn Phe  Ser Ser Pro 
    1010                 1015                 1020             


His Ala  Arg Arg Lys Val Leu  Ala Gly Val Val Met  Thr Thr Gly 
    1025                 1030                 1035             


Thr Asp  Val Lys Asp Ala Lys  Val Ile Ser Val Ser  Thr Gly Thr 
    1040                 1045                 1050             


Lys Cys  Ile Asn Gly Glu Tyr  Met Ser Asp Arg Gly  Leu Ala Leu 
    1055                 1060                 1065             


Asn Asp  Cys His Ala Glu Ile  Ile Ser Arg Arg Ser  Leu Leu Arg 
    1070                 1075                 1080             


Phe Leu  Tyr Thr Gln Leu Glu  Leu Tyr Leu Asn Asn  Lys Asp Asp 
    1085                 1090                 1095             


Gln Lys  Arg Ser Ile Phe Gln  Lys Ser Glu Arg Gly  Gly Phe Arg 
    1100                 1105                 1110             


Leu Lys  Glu Asn Val Gln Phe  His Leu Tyr Ile Ser  Thr Ser Pro 
    1115                 1120                 1125             


Cys Gly  Asp Ala Arg Ile Phe  Ser Pro His Glu Pro  Ile Leu Glu 
    1130                 1135                 1140             


Glu Pro  Ala Asp Arg His Pro  Asn Arg Lys Ala Arg  Gly Gln Leu 
    1145                 1150                 1155             


Arg Thr  Lys Ile Glu Ser Gly  Gln Gly Thr Ile Pro  Val Arg Ser 
    1160                 1165                 1170             


Asn Ala  Ser Ile Gln Thr Trp  Asp Gly Val Leu Gln  Gly Glu Arg 
    1175                 1180                 1185             


Leu Leu  Thr Met Ser Cys Ser  Asp Lys Ile Ala Arg  Trp Asn Val 
    1190                 1195                 1200             


Val Gly  Ile Gln Gly Ser Leu  Leu Ser Ile Phe Val  Glu Pro Ile 
    1205                 1210                 1215             


Tyr Phe  Ser Ser Ile Ile Leu  Gly Ser Leu Tyr His  Gly Asp His 
    1220                 1225                 1230             


Leu Ser  Arg Ala Met Tyr Gln  Arg Ile Ser Asn Ile  Glu Asp Leu 
    1235                 1240                 1245             


Pro Pro  Leu Tyr Thr Leu Asn  Lys Pro Leu Leu Ser  Gly Ile Ser 
    1250                 1255                 1260             


Asn Ala  Glu Ala Arg Gln Pro  Gly Lys Ala Pro Asn  Phe Ser Val 
    1265                 1270                 1275             


Asn Trp  Thr Val Gly Asp Ser  Ala Ile Glu Val Ile  Asn Ala Thr 
    1280                 1285                 1290             


Thr Gly  Lys Asp Glu Leu Gly  Arg Ala Ser Arg Leu  Cys Lys His 
    1295                 1300                 1305             


Ala Leu  Tyr Cys Arg Trp Met  Arg Val His Gly Lys  Val Pro Ser 
    1310                 1315                 1320             


His Leu  Leu Arg Ser Lys Ile  Thr Lys Pro Asn Val  Tyr His Glu 
    1325                 1330                 1335             


Ser Lys  Leu Ala Ala Lys Glu  Tyr Gln Ala Ala Lys  Ala Arg Leu 
    1340                 1345                 1350             


Phe Thr  Ala Phe Ile Lys Ala  Gly Leu Gly Ala Trp  Val Glu Lys 
    1355                 1360                 1365             


Pro Thr  Glu Gln Asp Gln Phe  Ser Leu Thr 
    1370                 1375             


<210>  287
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HIV NES

<400>  287

Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu 
1               5                   10      


<210>  288
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cas sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (21)..(26)
<223>  Xaa can be any naturally occurring amino acid

<400>  288

Leu Xaa Gly Lys Glu Ile Asn Xaa Xaa Xaa Xaa Xaa Leu Ile Xaa Lys 
1               5                   10                  15      


Phe Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25      


<210>  289
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cas sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(31)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(38)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (41)..(50)
<223>  Xaa can be any naturally occurring amino acid

<400>  289

Arg Asn Xaa Ile Xaa Xaa Asn Val Xaa Xaa Xaa Xaa Xaa Phe Xaa Tyr 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Val Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa 
    50  


<210>  290
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cas sequence


<220>
<221>  misc_feature
<222>  (2)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (31)..(33)
<223>  Xaa can be any naturally occurring amino acid

<400>  290

Leu Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Lys Xaa Xaa Val Xaa Xaa 
1               5                   10                  15      


Asn Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Arg Asp Xaa Xaa 
            20                  25                  30          


Xaa 
    


<210>  291
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cas sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  291

Pro Phe Xaa Tyr Xaa Xaa Xaa Arg Xaa Lys Asn Leu Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Leu Phe Xaa Xaa Xaa 
            20      


<210>  292
<211>  1057
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MH_4866

<400>  292

Met Glu Glu Asn Lys Val Arg Phe Thr Asn Thr Ser Asn Val Lys Arg 
1               5                   10                  15      


Pro Lys Ser Leu Leu Lys Gln Met Gly His Lys Ser Thr Phe Leu Leu 
            20                  25                  30          


Asp Asp Thr Leu Ile Val Thr Ser Val Ala Lys Gly Lys Asn Glu Asp 
        35                  40                  45              


Gln Lys Gly Lys Glu Gln Ala Ala Ser Lys Ser Lys Val Ala Pro Gln 
    50                  55                  60                  


Ser His Ile Glu Leu Leu Ser Thr Ile Asp Gly Glu Val Leu Gly Gly 
65                  70                  75                  80  


Arg Lys Glu Leu Leu Ala Thr Thr Val Ser Arg Gln Glu Val Thr Ile 
                85                  90                  95      


Ser Gly Lys Ile Tyr Asn Leu Asn Thr Lys Thr Pro Glu Ser Thr Thr 
            100                 105                 110         


Val Thr Met Ala Asn Pro Ala Val Leu Leu Gln Lys Asn Ser Ser Thr 
        115                 120                 125             


Thr Gln Val Ala Arg Lys Thr Asp Tyr Leu Gly Ile Lys Ser Ala Leu 
    130                 135                 140                 


Glu Lys Glu Phe Phe Asn Asp Phe Ser Asn Ser Gly Phe Asn Asp Asn 
145                 150                 155                 160 


Val Arg Val Gln Ile Ala Tyr Asn Ile Leu Asp Ile Arg Lys Ile Leu 
                165                 170                 175     


Ala Thr Thr Ile Asn Asn Ile Val Ser Met Phe Tyr Asn Leu Asp Arg 
            180                 185                 190         


Thr Thr Gly Asp Ile Ala Asp Glu Thr Lys Lys Ser Thr Asn Thr Asp 
        195                 200                 205             


Ile Ile Gly Met Ile Lys Thr Tyr Leu Lys Tyr Asp Gln Ala Lys Asn 
    210                 215                 220                 


Ser Asn Asp Pro Ser Ile Lys Lys Thr Phe Asn Lys Ala Glu Glu Leu 
225                 230                 235                 240 


Leu Ile Asn Thr Lys Ala Tyr His Thr Tyr Phe Asp Arg Leu Phe Thr 
                245                 250                 255     


Thr Pro Thr Arg Gln Ala Phe Lys Ala Gly Lys Leu Lys Asp Thr Asn 
            260                 265                 270         


Asp Lys Lys Ser Asn Leu Pro Cys Glu Phe Ser Lys Leu Ser Glu Lys 
        275                 280                 285             


Asp Gln Glu Glu Phe Lys Asn Glu Ala Ile Thr His Asn Tyr Asp Val 
    290                 295                 300                 


Leu Arg Leu Leu Gly Leu Gly Arg Gln Leu Val Val His Glu Lys Tyr 
305                 310                 315                 320 


Lys Ser Asp Glu His Asn Lys Asp Asn Ser Ile Glu Ser Leu Phe Asn 
                325                 330                 335     


Ile Asp Lys Ile Ile Arg Asn Ser Asn Asp Thr Met Asp Leu Leu Lys 
            340                 345                 350         


Arg Leu Asp Asn Ile Tyr Leu Glu Ser Ala Glu Gln Ile Asp Asn Ser 
        355                 360                 365             


Phe Lys Lys Ser Ser Ala Thr Asn Cys Leu Ile Leu Glu Glu Leu Tyr 
    370                 375                 380                 


Lys Arg Ile Gly Lys Ala Lys Thr Gln Ala Glu Leu Tyr Lys Asp Tyr 
385                 390                 395                 400 


Tyr Arg Tyr Ala Ile Leu Lys Glu Asp Gln Cys Leu Gly Ile Ser Phe 
                405                 410                 415     


Asn Arg Ile Lys Glu Ala Val Leu Glu Lys Leu Lys Glu Glu Gln Arg 
            420                 425                 430         


Tyr Lys Asn Phe Glu Tyr Arg Asn Asp Asn Lys Arg Phe Tyr Thr Leu 
        435                 440                 445             


Cys Asn Phe Val Leu Trp His Tyr Met Val Asp Leu Arg Asp Arg Asn 
    450                 455                 460                 


Glu Thr Arg Ala Gly His Gln Gln Thr Asp Arg Asn Glu Ile Glu Glu 
465                 470                 475                 480 


Leu Lys Ser Lys Leu Arg Ala Cys Cys Asp Asn Asn Gly Asp Gly Gly 
                485                 490                 495     


Glu Asn Gln Lys Tyr Ala Ile Tyr Lys Glu Phe Val Asn Phe His Trp 
            500                 505                 510         


Thr Asp Leu Arg Thr Ser Ile Asn Thr Leu Tyr Asp Leu Cys Val Lys 
        515                 520                 525             


Tyr Lys Tyr Thr Ala Lys Asn Tyr Arg Ile Asp Ser Lys Ile Gln Ile 
    530                 535                 540                 


Asp Asn Gln Leu Ser Ser Ser Ala Asn Asn Val Lys Thr Phe Val Lys 
545                 550                 555                 560 


Tyr Ile Tyr Phe Leu Ser Glu Phe Leu Asp Gly Lys Glu Val Asn Val 
                565                 570                 575     


Phe Phe Asn Glu Leu Val Glu Lys Phe Ser Asn Ile Ala Glu Ile Val 
            580                 585                 590         


Thr Thr Val Asn Asp Asn Ile Asn Asn Ser Ser Lys Lys Ser Pro Asn 
        595                 600                 605             


Ile Ser Phe Leu Pro Gln Tyr Ser Leu Phe Gln Glu Ala Gly Thr Val 
    610                 615                 620                 


Ala Asp Gln Leu Arg Asn Ala Arg Asn Ile Lys His Ala Thr Leu Arg 
625                 630                 635                 640 


Ala Arg Ile Asn Asp Lys Val Ala Asp Lys Asp Ser Lys Met Ser Pro 
                645                 650                 655     


Ser Lys Gln Thr Ile Ser Asp Ala Leu Tyr Met Leu Ile Asp Glu Asn 
            660                 665                 670         


Asp Thr Ile Glu Asn Tyr Lys Gln Leu Ile Trp Asp Glu Lys Glu Ser 
        675                 680                 685             


Gly Thr Trp Val Lys Lys Ala Thr Gly Asn Asn Lys Val Arg Asn Phe 
    690                 695                 700                 


Ile Ile Asn Asn Ile Ile Met Ser Lys Trp Phe Met Tyr Ile Ser Lys 
705                 710                 715                 720 


Tyr Ser Asp Pro Arg Asn Cys Ser Lys Ile Met His Asn Lys Glu Ala 
                725                 730                 735     


Val Val Phe Ala Met Ser Ser Ile Pro Asp Ala Gln Ile Glu Lys Tyr 
            740                 745                 750         


Tyr Lys Arg Val Thr Ala Lys Ser Val Gln Tyr Gly Asn Lys Thr Ala 
        755                 760                 765             


Glu Glu Met Arg Ser Ile Val Ile Asp Ala Leu Met Asn Phe Ser Leu 
    770                 775                 780                 


Lys Pro Val Leu Thr Gly Val Ala Asn Asn Asp Tyr Ser Asn Glu Asn 
785                 790                 795                 800 


Arg Glu Arg Asp Ile Gly Ile Ile Gln Leu Tyr Leu Thr Val Ala Tyr 
                805                 810                 815     


Ile Val Thr Lys Ser Leu Val Asn Val Asn Lys Arg Phe Leu Leu Ala 
            820                 825                 830         


Phe Ser Cys Leu Glu Arg Asp Val Pro Leu Ile Leu Asn Gly Lys Ser 
        835                 840                 845             


Phe Lys Asp Ala Asn Ile Leu Val Leu Ser Glu Lys Phe Ile Ala Glu 
    850                 855                 860                 


Asp Gln Glu Ile Glu Gln Lys Tyr Lys Leu Ala Lys Lys Asn Arg Ile 
865                 870                 875                 880 


Thr Pro Asn Met Ser Lys Glu Asp Val Lys Asn Val Phe Lys Glu Leu 
                885                 890                 895     


Asn Ala Glu Tyr Lys Ser Lys His Tyr Ala Glu Ser Leu Thr Arg Pro 
            900                 905                 910         


Arg Asp Pro Asp Ser Lys Lys Asp Lys Ser Cys Ala Tyr Leu Val Asn 
        915                 920                 925             


Asn Leu Asn Glu Ala Lys Lys Ile Glu Asn Val Leu Met Asp Phe Lys 
    930                 935                 940                 


Asn Lys Val Asp His Leu Asn Val Val Lys Ser Ala Pro Glu Tyr Met 
945                 950                 955                 960 


Ser Asn Ile Lys Asn Ile Asp Ser Phe Tyr Gly Ile Phe Cys Phe Ala 
                965                 970                 975     


Leu Gln Asn Ile Leu Ala Asp Lys Met Ile Lys Trp Ser Val Asn Glu 
            980                 985                 990         


Lys Asn Ser Lys Glu Asp Val Glu  Ile Ile Asn Ser Tyr  Gly Gln Glu 
        995                 1000                 1005             


Leu Lys  Lys Lys Leu Asp Ser  Arg His Thr Phe Asp  Arg Asp Ala 
    1010                 1015                 1020             


Met Trp  Ile Ile Asn Met Pro  Phe Ala Tyr Asn Phe  Pro Arg Tyr 
    1025                 1030                 1035             


Lys Asn  Leu Ser Ser Glu Tyr  Leu Phe Tyr Asp Lys  Glu Tyr Glu 
    1040                 1045                 1050             


Lys Thr  Lys Lys 
    1055         


<210>  293
<211>  945
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  037 - emb|OIZA01000315.1|  compressed

<400>  293

Met Ala Lys Lys Lys Arg Met Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Lys Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Ile Ile Lys Ala Asn Asp Asp Val Thr Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Ile Gly Asp Val Ser Gly Asp Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Ile Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Leu Asn Tyr Arg Val Pro Tyr Leu Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Lys Pro Asn Lys Ile Ser Ala Trp Lys Lys 
225                 230                 235                 240 


Arg Glu Asn Phe Ile Asn Phe Tyr Asn Glu Ala Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asn Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Glu Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Lys Ala Tyr Gly Glu Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Thr Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Val Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Phe 
    530                 535                 540                 


His Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Ala Pro Lys Glu Pro Leu 
            580                 585                 590         


Leu Lys Asp Ala Leu Leu Ala Leu Gly Val Ser Ser Asn Asp Phe Asp 
        595                 600                 605             


Glu Lys Tyr Glu Lys Tyr Phe Lys Thr Asp Val Asp Ala Asp Lys Asp 
    610                 615                 620                 


His Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn Asn Ser 
625                 630                 635                 640 


Arg Phe Lys Tyr Val Val Lys Tyr Ile Asn Pro Ala Asp Ile Asn Gly 
                645                 650                 655     


Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys Ile Pro 
            660                 665                 670         


Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu Glu Glu 
        675                 680                 685             


Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile Ser Lys 
    690                 695                 700                 


Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn Val Glu 
705                 710                 715                 720 


Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile Val Tyr 
                725                 730                 735     


Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr Leu Ala 
            740                 745                 750         


Leu Tyr Phe Val Glu Arg Asp Gly Phe Phe Tyr Lys Gln Ile Cys Glu 
        755                 760                 765             


Lys Lys Leu Ile Glu Thr Leu Lys Lys Lys Asp Lys Lys Gln Leu Tyr 
    770                 775                 780                 


Asn Asp Asp Asp Tyr Leu Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys 
785                 790                 795                 800 


Tyr Arg Glu Glu Thr Lys Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg 
                805                 810                 815     


Asp Ile Met Lys Lys Tyr Leu Pro Asn Asp Lys Asp Arg Glu Glu Tyr 
            820                 825                 830         


Asn Lys Phe Phe Lys Gln Tyr Arg Asn Asn Ile Val His Leu Lys Ile 
        835                 840                 845             


Ile Ala Lys Leu Ser Glu Leu Thr Lys Asn Ile Asp Lys Asp Ile Asn 
    850                 855                 860                 


Ser Tyr Phe Asp Ile Tyr His Tyr Cys Thr Gln Arg Val Met Phe Asp 
865                 870                 875                 880 


Tyr Cys Lys Lys Asn Asn Asn Val Val Leu Ala Lys Met Lys Asp Leu 
                885                 890                 895     


Ala His Ile Lys Ser Asp Cys Asp Glu Phe Ser Ser Lys His Thr Tyr 
            900                 905                 910         


Pro Tyr Ser Ser Ala Val Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr 
        915                 920                 925             


Asn Val Pro Arg Phe Lys Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys 
    930                 935                 940                 


Gln 
945 


<210>  294
<211>  924
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PIG-022_GL0026351 compressed

<400>  294

Met Ala Glu Ser Tyr Lys Ile Lys Ser Lys Lys Thr Arg Thr Lys Arg 
1               5                   10                  15      


Ala Gly Leu Lys Ser Ser Phe Val Asn Glu Asn Lys Gly Leu Met Thr 
            20                  25                  30          


Ala Phe Gly Lys Gly Asn Asn Ala Val Ile Glu Lys Arg Ile Ser Gly 
        35                  40                  45              


Asn Leu Ile Glu Asn Val Ser Asn Lys Pro Arg Phe Ser Val Glu Phe 
    50                  55                  60                  


Gly Asn Lys Glu Tyr Ile Ile Asn Asp Lys Lys Leu Gly Ile Val Ser 
65                  70                  75                  80  


Asp Asp Pro Arg Glu Ser Gln Lys Pro Val Gly Glu Asp Gly Ile His 
                85                  90                  95      


Cys Lys Arg Ala Leu Glu Glu Arg Tyr Phe Gly Lys Thr Phe Asn Asp 
            100                 105                 110         


Asn Ile His Ile Gln Leu Ile Tyr Ser Ile Leu Asp Leu Glu Lys Ile 
        115                 120                 125             


Leu Ala Val His Ser Asn Asn Ile Val Tyr Thr Phe Asp Asn Leu Arg 
    130                 135                 140                 


Arg Lys Glu Thr Asp Glu Tyr Asp Asp Phe Ile Gly Tyr Met Ser Thr 
145                 150                 155                 160 


Val Asn Ser Tyr Glu Glu Phe Met Asn Pro Glu Lys Leu Leu Pro Gly 
                165                 170                 175     


Lys Asp Gln Ser Val Tyr Asp Asn Ile Asn Arg Ser Arg Glu Thr Phe 
            180                 185                 190         


Leu Glu Tyr Arg Lys Asn Pro Arg Leu Gly Tyr Phe Gly Lys Val Phe 
        195                 200                 205             


Tyr Glu Lys Val Thr Asp Pro Lys Asn Lys Ser Lys Lys Lys Met Arg 
    210                 215                 220                 


Leu Ile Ser Glu Lys Glu Met Tyr Tyr Ile Phe Ala Leu Leu Gly Gly 
225                 230                 235                 240 


Leu Arg Gln Phe Cys Thr His Asp Lys Asn Arg Ala Arg Asn Trp Leu 
                245                 250                 255     


Tyr Ser Leu Asp Thr Met Leu Asn Asp Asp Ala Lys Ala Val Leu Asp 
            260                 265                 270         


Lys Tyr Tyr Val Ser Thr Val Ser Ser Leu Asn Lys His Phe Val Asp 
        275                 280                 285             


Asn Ser Ala Lys Lys Asp Phe Ser Ile Ile Phe Asn Ala Leu Asn Ile 
    290                 295                 300                 


Thr Asp Ile Glu Leu Lys Lys Asn Ile Ala Lys Glu Tyr Tyr Glu Phe 
305                 310                 315                 320 


Val Cys Arg Lys Asn Phe Lys Asn Ile Gly Phe Ser Ile Lys Lys Leu 
                325                 330                 335     


Arg Glu Tyr Leu Leu Glu Lys Pro Glu Phe Cys Asn Leu Lys Glu Asp 
            340                 345                 350         


Lys Tyr Asn Ser Val Arg Ser Lys Leu Tyr Arg Leu Ile Asp Phe Ile 
        355                 360                 365             


Ile Tyr Leu Asn Tyr Lys Asp Ala Lys Phe Glu Asn Asp Asn Asp Glu 
    370                 375                 380                 


Lys Ile Glu Arg Phe Val Ser Lys Leu Arg Lys Cys Pro Asp Glu Ala 
385                 390                 395                 400 


Ser Lys Glu Thr Val Tyr Gln Thr Glu Ser Asp Ile Ile Lys Lys Ser 
                405                 410                 415     


Ile Tyr Gly Ser Ile Asn Ser Ile Lys Arg Gly Met Met Ser Val Lys 
            420                 425                 430         


Ser Lys Tyr Gly Lys Leu Glu Leu Asp Lys Gln Thr Ile Asn Gln Leu 
        435                 440                 445             


Lys Arg Ala Val Asp Asp Ile Ser Ile Asn Thr Lys Gly Asp Tyr Phe 
    450                 455                 460                 


Thr Lys Leu Met Tyr Leu Ile Ser Leu Leu Ile Asp Gly Lys Glu Ile 
465                 470                 475                 480 


Asn Asp Leu Leu Thr Thr Leu Ile His Gln Phe Glu Asn Ile Ala Ser 
                485                 490                 495     


Phe Ile Asp Val Met Lys Lys Glu Asn Ile Asn Tyr Glu Phe Ala Glu 
            500                 505                 510         


Lys Tyr Lys Phe Phe Asn Thr Ser Lys Asn Ile Ala Cys Glu Leu Arg 
        515                 520                 525             


Thr Val Asn Ser Phe Ala Arg Met Thr Gly Phe Met Glu Asn Asp Glu 
    530                 535                 540                 


Ser Thr Lys Phe Ile Met Phe Arg Glu Ala Ala Asp Ile Leu Gly Thr 
545                 550                 555                 560 


Ser Tyr Thr Asp Asp Glu Leu Thr Asp His Leu Asn Leu Lys Lys Thr 
                565                 570                 575     


Arg Leu Asn Ala Arg Ser Lys Ala Asp Thr Gly Leu Arg Asn Phe Ile 
            580                 585                 590         


Ile Ser Asn Val Ile Lys Ser Ser Arg Phe Lys Tyr Leu Ile Arg Tyr 
        595                 600                 605             


Ser Asn Pro Lys Lys Val Lys Ala Ile Ala Glu Asn Lys Lys Leu Val 
    610                 615                 620                 


Arg Phe Val Leu Asp Lys Ile Pro Asp Pro Gln Ile Ile Arg Tyr Cys 
625                 630                 635                 640 


Asn Thr Cys Gly Phe Lys Val Gly Glu Arg Gln Glu Asn Ile Asn Thr 
                645                 650                 655     


Leu Ala Lys Ala Ile Thr Asn Phe Ser Phe Ser Ala Phe Glu Lys Val 
            660                 665                 670         


Lys Gln Ser Ala Asn Val Glu Asn Asp Thr Pro Asp Ala Ile Asp Lys 
        675                 680                 685             


Ala Gln Lys Gln Gly Leu Ile Ser Leu Tyr Leu Thr Val Leu Tyr Leu 
    690                 695                 700                 


Phe Ile Lys Asn Met Val Tyr Val Asn Ser Arg Tyr Val Leu Ala Phe 
705                 710                 715                 720 


His Cys Leu Glu Arg Asp Ser Gln Leu Leu Lys Ile Thr Ser Gly Tyr 
                725                 730                 735     


Asn Asn Ser Ser Tyr Asn Asn Leu Thr Asn Tyr Phe Ile Asp Asn Lys 
            740                 745                 750         


Tyr Leu Asn Pro His Ala Ser Arg Tyr Leu Lys Val Asn Ile Ser Asn 
        755                 760                 765             


Ala Asp Glu Trp Ser Ile Val Lys Phe Arg Asn Gly Thr Ala His Leu 
    770                 775                 780                 


Asn Ser Val Arg Asn Ile Asp Thr Cys Ile Glu Gly Leu Lys Asp Phe 
785                 790                 795                 800 


Lys Ser Tyr Phe Glu Ile Tyr Ala Tyr Thr Val Gln Lys Ser Ile Lys 
                805                 810                 815     


Lys Tyr Phe Asp Ala Glu Phe Ser Glu Asp Arg Asn Ile Glu Asp Gly 
            820                 825                 830         


Lys Ile Ser Leu Cys Asn Gly Val Tyr Ile His Glu Arg Gln Lys Asn 
        835                 840                 845             


Gly Lys Pro Lys Ile Thr Val Lys Ile Asn Pro Lys Thr Ile Glu Tyr 
    850                 855                 860                 


Met Glu Ser Val Asp Lys Tyr Gly Ser Tyr Thr Lys Asp Phe Val Lys 
865                 870                 875                 880 


Ala Leu Asn Thr Pro Phe Gly Tyr Cys Leu Ala Arg Tyr Lys Asn Leu 
                885                 890                 895     


Ser Ile Glu Pro Leu Phe Asp Arg Asn Thr Val Tyr Asn Lys Glu Asp 
            900                 905                 910         


Val Thr Glu Glu Phe Ser Val Asn Ser Lys Glu Gln 
        915                 920                 


<210>  295
<211>  1022
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PIG-046_GL0077813 compressed

<400>  295

Met Ala Lys Lys Ile Thr Ala Lys Gln Arg Arg Glu Glu Arg Glu Arg 
1               5                   10                  15      


Gln Asn Lys Gln Lys Trp Ala Lys Lys Gln Asp Asp Ala Thr Ala Val 
            20                  25                  30          


Phe Glu Cys Glu Ala Asn Ile Lys Pro Ala Asp Ser Lys Asp Glu Asp 
        35                  40                  45              


Cys Ala Asn Thr Ser Ile Lys Arg Lys Lys Thr Gln Ala Lys Ala Met 
    50                  55                  60                  


Gly Leu Lys Thr Val Leu Gly Phe Asp Asn Lys Ile Ala Ile Ala Ser 
65                  70                  75                  80  


Phe Thr Ser Ser Lys Asp Ser Lys Ser Ser His Ile Glu Arg Ile Thr 
                85                  90                  95      


Asp Pro Asn Gly Lys Thr Ile Arg Glu Asp Val Arg Met Phe Asp Ser 
            100                 105                 110         


Asn Val Asp Glu Cys Ser Ile Asn Leu Glu Lys Arg Met Thr Val Glu 
        115                 120                 125             


Glu Arg Gln Lys Asp Gly Thr Ile Lys Lys Asp Glu Lys Asp Val Lys 
    130                 135                 140                 


Ser Thr Ile Cys Asn Pro Tyr Ser Asn Glu Cys Gly Lys Asp Tyr Ile 
145                 150                 155                 160 


Gly Ile Lys Ser Val Ala Glu Glu Leu Phe Phe Gly Arg Thr Phe Pro 
                165                 170                 175     


Asn Asp Asn Leu Arg Val Gln Ile Ala Tyr Asn Ile Phe Asp Ile Gln 
            180                 185                 190         


Lys Ile Phe Gly Thr Tyr Ile Asn Asn Ile Ile Tyr Ser Phe Tyr Asn 
        195                 200                 205             


Leu Ser Arg Asp Glu Phe Gln Ser Asp Asn Asp Val Ile Gly Thr Leu 
    210                 215                 220                 


Tyr Met Leu Lys Asp Phe Asp Gly Gln Lys Glu Thr Asp Thr Phe Arg 
225                 230                 235                 240 


Gln Ala Arg Ala Leu Leu Glu Arg Thr Glu Ala Tyr Tyr Ser Tyr Phe 
                245                 250                 255     


Asp Asn Val Phe Lys Lys Ile Asp Lys Lys Lys Lys Arg Asn Asp Asp 
            260                 265                 270         


Tyr Glu Gly Lys Arg Asn Glu Ile Leu Arg Tyr Asn Phe Asn Val Leu 
        275                 280                 285             


Arg Val Leu Ser Phe Leu Arg Gln Ile Cys Ala His Ala Lys Val Lys 
    290                 295                 300                 


Val Ser Ser Asp Asn Asp Arg Glu Lys Gly Gly Val Phe Val Asp Ser 
305                 310                 315                 320 


Leu Asp Ala Leu Phe Asn Ile Ser Ser Phe Phe Asp Ala Val Ala Pro 
                325                 330                 335     


Glu Leu Asn Glu Val Ile Asn Ser Val Tyr Ser Lys Gly Ile Tyr Asp 
            340                 345                 350         


Ile Asn Asp Asn Phe Val Lys Asn Asp Lys Asn Asn Phe Tyr Ile Leu 
        355                 360                 365             


Ser Lys Ile Tyr Pro Glu Val Ala Arg Glu Asn Leu Leu Lys Glu Tyr 
    370                 375                 380                 


Tyr Tyr Phe Val Val Ser Lys Glu Gly Asn Asn Ile Gly Ile Ser Thr 
385                 390                 395                 400 


Lys Lys Leu Lys Glu Ala Ile Ile Ala Gln Asp Met Ser Tyr Ile Lys 
                405                 410                 415     


Ser Lys Asp Tyr Asp Thr Tyr Arg Asn Lys Leu Tyr Thr Val Leu Cys 
            420                 425                 430         


Phe Ile Leu Val Lys Glu Leu Asn Glu Arg Thr Thr Ile Arg Glu Gln 
        435                 440                 445             


Met Val Ala Asp Leu Arg Ala Asn Met Asn Gly Asp Ile Gly Arg Glu 
    450                 455                 460                 


Asp Ile Tyr Ser Lys Tyr Ala Lys Ile Ile Tyr Ala Gln Val Lys Pro 
465                 470                 475                 480 


Arg Phe Asp Gly Met Lys Asn Val Phe Glu Glu Glu Ala Lys Gly Val 
                485                 490                 495     


Ile Val Pro Asp Lys Glu Glu Ala Val Lys Phe Ser Asn Gly Ala Leu 
            500                 505                 510         


Asp Lys Ser Glu Ile Glu Arg Phe Cys Ile Thr Ser Ala Asn Thr Asp 
        515                 520                 525             


Ser Val Ala Lys Ile Ile Tyr Phe Leu Cys Lys Phe Leu Asp Gly Lys 
    530                 535                 540                 


Glu Ile Asn Glu Phe Cys Cys Ala Met Met Asn Lys Leu Asp Gly Ile 
545                 550                 555                 560 


Asn Asp Leu Met Glu Thr Ala Glu Gln Cys Gly Ala Lys Ile Glu Phe 
                565                 570                 575     


Val Asp Asn Phe Asn Val Leu Ser Lys Cys Gly Thr Ile Ser Gly Gln 
            580                 585                 590         


Ile Arg Val Val Lys Ser Ile Ser Lys Met Lys Lys Glu Ile Asp Val 
        595                 600                 605             


Asp Asn Glu Thr Ile Phe Leu Asp Ala Phe Glu Leu Leu Gly Lys Arg 
    610                 615                 620                 


Ile Glu Lys Tyr Lys Lys Asp Asp Ser Gly Asn Val Leu Arg Asn Asp 
625                 630                 635                 640 


Asp Gly Lys Val Leu Arg Thr Lys Glu Tyr Asn Asn Ile Arg Lys Met 
                645                 650                 655     


Leu Cys Lys Lys Asp Arg Arg Leu Asn Phe Ile Ala Asn Ser Ile Ile 
            660                 665                 670         


Lys Asn Lys Trp Phe Ser Tyr Ile Val Arg Tyr Asn Gln Pro Ser Glu 
        675                 680                 685             


Cys Gln Ala Ile Met Lys Asn Lys Thr Leu Val Lys Phe Ala Leu Asp 
    690                 695                 700                 


Glu Leu Pro Asp Leu Gln Ile Gln Arg Tyr Phe Val Ala Leu Tyr Gly 
705                 710                 715                 720 


Asp Glu Asp Leu Pro Ser Tyr Gly Glu Met Arg Lys Ile Leu Leu Lys 
                725                 730                 735     


Lys Leu His Asp Phe Ser Ile Arg Asp Phe Asp Glu Glu Ile Gly Ser 
            740                 745                 750         


Leu Phe Asp Glu Met Lys Arg Lys Asp Lys Phe Cys Glu Ser Asp Arg 
        755                 760                 765             


Lys Lys Cys Leu Phe Arg Leu Tyr Leu Thr Ile Ala Tyr Leu Ile Thr 
    770                 775                 780                 


Lys Ser Met Val Lys Ile Asn Thr Arg Phe Ser Ile Ala Cys Ala Thr 
785                 790                 795                 800 


Tyr Glu Arg Asp Tyr Ala Leu Leu Cys Ala Ser Asn Lys Gln Glu Arg 
                805                 810                 815     


Ala Trp Ser Ser Gly Ala Thr Ala Leu Ala Leu Thr Arg Lys Phe Leu 
            820                 825                 830         


Asn Gln Asp Lys Leu Ile Phe Glu Lys His Tyr Ala Arg Glu Gly Glu 
        835                 840                 845             


Ile Ser Lys Leu Pro Lys Glu Glu Arg Lys Ala Met Arg Lys Val Asn 
    850                 855                 860                 


Asp Gln Leu Leu Lys Gln Thr His Phe Ser Lys His Ser Tyr Cys Tyr 
865                 870                 875                 880 


Ile Val Asp Asn Val Asn Arg Leu Thr Gly Gly Glu Cys Arg Thr Asp 
                885                 890                 895     


Lys Arg Val Leu Pro Val Leu Asn Glu Lys Asn Asp Asn Ala Gly Ile 
            900                 905                 910         


Leu Ser Asp Phe Arg Lys Thr Ile Ala His Leu Asn Val Val His Lys 
        915                 920                 925             


Met Val Asp Tyr Val Ala Glu Ile Lys Gly Ile Thr Ser Tyr Tyr Ala 
    930                 935                 940                 


Phe Phe Cys Tyr Val Leu Gln Arg Met Pro Val Gly Asn Lys Asn Glu 
945                 950                 955                 960 


Lys Asn Ala Leu Lys Glu Lys Tyr Ser Glu Thr Ala Lys Ser Tyr Gly 
                965                 970                 975     


Thr Tyr Ser Lys Asp Phe Met Trp Leu Ile Asn Leu Pro Phe Ala Tyr 
            980                 985                 990         


Asn Leu Pro Arg Tyr Lys Asn Leu  Ser Asn Glu Gln Leu  Phe Tyr Asp 
        995                 1000                 1005             


Glu Glu  Glu Arg Asn Glu Thr  Glu Gly Gln Ile Asp  Arg Leu 
    1010                 1015                 1020         


<210>  296
<211>  1027
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  pig_chimera compressed

<400>  296

Met Ala Lys Lys Ile Thr Ala Lys Gln Arg Arg Glu Glu Arg Glu Arg 
1               5                   10                  15      


Gln Asn Lys Gln Lys Trp Ala Lys Lys Gln Ala Asp Ala Thr Ala Val 
            20                  25                  30          


Phe Glu Cys Glu Ala Asp Ile Lys Pro Ala Asp Ser Lys Asp Glu Asp 
        35                  40                  45              


Cys Thr Asn Ile Tyr Ile Lys Arg Glu Lys Lys Lys Thr Gln Ala Lys 
    50                  55                  60                  


Ala Met Gly Leu Lys Thr Val Leu Gly Phe Asp Asn Lys Ile Ala Ile 
65                  70                  75                  80  


Ala Ser Phe Met Ser Ser Lys Asp Ser Lys Ser Ser His Ile Glu Arg 
                85                  90                  95      


Ile Thr Asp Pro Asn Gly Lys Thr Ile Arg Glu Asp Val Arg Met Phe 
            100                 105                 110         


Asp Ser Asn Val Asp Glu Cys Ser Ile Asn Leu Glu Lys Arg Met Thr 
        115                 120                 125             


Val Glu Glu Arg Gln Lys Asp Gly Thr Ile Lys Lys Asp Glu Lys Asp 
    130                 135                 140                 


Val Lys Ser Thr Ile Cys Asn Pro Tyr Ser Asn Glu Cys Gly Lys Asp 
145                 150                 155                 160 


Tyr Ile Gly Ile Lys Ser Val Ala Glu Glu Leu Phe Phe Gly Arg Thr 
                165                 170                 175     


Phe Pro Asn Asp Asn Leu Arg Val Gln Ile Ala Tyr Asn Ile Phe Asp 
            180                 185                 190         


Ile Gln Lys Ile Leu Gly Thr Tyr Ile Asn Asn Ile Ile Tyr Ser Phe 
        195                 200                 205             


Tyr Asn Leu Ser Arg Asp Glu Ser Gln Ser Asp Asn Asp Val Ile Gly 
    210                 215                 220                 


Thr Leu Tyr Met Leu Lys Asp Phe Asp Gly Gln Lys Glu Thr Asp Thr 
225                 230                 235                 240 


Phe Arg Gln Ala Arg Ala Leu Leu Glu Arg Thr Glu Ala Tyr Tyr Ser 
                245                 250                 255     


Tyr Phe Asp Asn Val Phe Lys Lys Ile Asp Lys Asn Lys Lys Lys Ser 
            260                 265                 270         


Asp Asp Cys Lys Arg Glu Arg Asn Glu Ile Leu Arg Tyr Asn Phe Asn 
        275                 280                 285             


Val Leu Arg Val Leu Ser Phe Leu Arg Gln Ile Cys Ala His Ala Gln 
    290                 295                 300                 


Val Lys Ile Ser Asn Glu His Asp Arg Glu Lys Gly Gly Gly Leu Val 
305                 310                 315                 320 


Asp Ser Leu Asp Ala Leu Phe Asn Ile Ser Arg Phe Phe Asp Ala Val 
                325                 330                 335     


Ala Pro Glu Leu Asn Glu Val Ile Asn Ser Val Tyr Ser Lys Gly Ile 
            340                 345                 350         


Asp Asp Ile Asn Asp Asn Phe Val Lys Asn Gly Lys Asn Asn Phe Tyr 
        355                 360                 365             


Ile Leu Ser Lys Ile Tyr Pro Glu Val Ala Arg Glu Asp Leu Leu Arg 
    370                 375                 380                 


Glu Tyr Tyr Tyr Phe Val Val Ser Lys Glu Gly Asn Asn Ile Gly Ile 
385                 390                 395                 400 


Ser Thr Lys Lys Leu Lys Glu Ala Ile Ile Val Gln Asp Met Ser Tyr 
                405                 410                 415     


Ile Lys Ser Glu Asp Tyr Asp Thr Tyr Arg Asn Lys Leu Tyr Thr Val 
            420                 425                 430         


Leu Cys Phe Ile Leu Val Lys Glu Leu Asn Glu Arg Thr Thr Ile Arg 
        435                 440                 445             


Glu Gln Met Val Ala Asp Leu Arg Ala Asn Met Asn Gly Asp Ile Gly 
    450                 455                 460                 


Arg Glu Asp Ile Tyr Ser Lys Tyr Ala Lys Ile Ile Tyr Ala Gln Val 
465                 470                 475                 480 


Lys Pro Arg Phe Asp Thr Met Lys Ser Ala Phe Glu Glu Glu Ala Lys 
                485                 490                 495     


Asp Val Ile Val Pro Asp Lys Lys Lys Pro Val Lys Phe Ser His Gly 
            500                 505                 510         


Lys Leu Asp Lys Asn Glu Ile Glu Arg Phe Cys Ile Thr Ser Ala Asn 
        515                 520                 525             


Thr Asp Ser Val Ala Lys Ile Ile Tyr Phe Leu Cys Lys Phe Leu Asp 
    530                 535                 540                 


Gly Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Met Asn Lys Leu Asp 
545                 550                 555                 560 


Gly Ile Asn Asp Leu Ile Glu Thr Ala Glu Gln Cys Gly Ala Lys Val 
                565                 570                 575     


Glu Phe Val Asp Lys Phe Ser Val Leu Ser Asn Cys Glu Thr Ile Ser 
            580                 585                 590         


Asp Gln Ile Arg Ile Val Lys Ser Ile Ser Lys Met Lys Lys Glu Ile 
        595                 600                 605             


Ala Ile Asp Asn Asp Thr Ile Phe Leu Asp Ala Leu Glu Leu Leu Gly 
    610                 615                 620                 


Arg Lys Ile Asp Lys Tyr Lys Lys Asp Ala Thr Gly Lys Tyr Leu Lys 
625                 630                 635                 640 


Asp Glu Asn Gly Lys Tyr Leu Tyr Ser Lys Glu Tyr Asp Asp Phe Gln 
                645                 650                 655     


Tyr Met Phe Phe Lys Asp Ser His Arg Val Arg Asn Phe Ile Ser Asn 
            660                 665                 670         


Ser Val Ile Lys Ser Lys Trp Phe Ser Tyr Ile Val Arg Tyr Asn Gln 
        675                 680                 685             


Pro Ser Glu Cys Arg Ala Ile Met Lys Asn Lys Thr Leu Val Lys Phe 
    690                 695                 700                 


Ala Leu Asp Glu Leu Pro Asp Leu Gln Ile Gln Arg Tyr Phe Val Ala 
705                 710                 715                 720 


Leu Tyr Gly Asp Glu Asp Leu Pro Ser Tyr Gly Glu Met Arg Lys Ile 
                725                 730                 735     


Leu Leu Lys Lys Leu His Asp Phe Ser Ile Lys Gly Phe Leu Asp Glu 
            740                 745                 750         


Ile Val Leu Leu Ser Asp Leu Asp Met Glu Ser Gln Asp Lys Tyr Cys 
        755                 760                 765             


Glu Lys Glu Gln Lys Lys Ser Leu Phe Arg Leu Tyr Leu Thr Ile Ala 
    770                 775                 780                 


Tyr Leu Ile Thr Lys Ser Met Val Lys Ile Asn Thr Arg Phe Ser Ile 
785                 790                 795                 800 


Ala Cys Ala Thr Tyr Glu Arg Asp Tyr Ala Leu Leu Cys Ala Ser Asn 
                805                 810                 815     


Lys Gln Glu Arg Ala Trp Ser Ser Gly Ala Thr Ala Leu Ala Leu Thr 
            820                 825                 830         


Arg Arg Phe Leu Asn Gln Asp Lys Leu Ile Phe Glu Lys His Tyr Ala 
        835                 840                 845             


Arg Glu Gly Glu Ile Ser Lys Leu Pro Lys Glu Glu Arg Lys Ala Met 
    850                 855                 860                 


Arg Lys Val Asn Asp Gln Leu Leu Lys Arg Thr His Phe Ser Lys His 
865                 870                 875                 880 


Ser Tyr Cys Tyr Ile Val Asp Asn Val Asn Arg Leu Thr Gly Gly Glu 
                885                 890                 895     


Cys Arg Thr Asp Lys Arg Val Leu Pro Val Leu Asn Glu Lys Asn Asp 
            900                 905                 910         


Asn Ala Gly Ile Leu Leu Asp Phe Arg Lys Thr Ile Ala His Leu Asn 
        915                 920                 925             


Val Val His Lys Met Val Asp Tyr Val Asp Glu Ile Lys Gly Ile Thr 
    930                 935                 940                 


Ser Tyr Tyr Ala Phe Phe Cys Tyr Val Leu Gln Arg Met Leu Val Gly 
945                 950                 955                 960 


Asn Asn Leu Asn Glu Lys Asn Ala Ile Lys Glu Lys Tyr Ser Ala Thr 
                965                 970                 975     


Val Lys Ser Phe Gly Thr Tyr Ser Lys Asp Phe Met Trp Leu Ile Asn 
            980                 985                 990         


Leu Pro Phe Ala Tyr Asn Leu Pro  Arg Tyr Lys Asn Leu  Ser Asn Glu 
        995                 1000                 1005             


Gln Leu  Phe Tyr Asp Glu Glu  Glu Arg Asn Glu Thr  Glu Glu Gln 
    1010                 1015                 1020             


Ile Asp  Arg Leu 
    1025         


<210>  297
<211>  966
<212>  PRT
<213>  Ruminococcus flavefaciens

<400>  297

Ile Glu Lys Lys Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser Thr 
1               5                   10                  15      


Leu Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly Ser 
            20                  25                  30          


Asp Ala Arg Leu Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser Val 
        35                  40                  45              


Asn Glu Gly Glu Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala Gly 
    50                  55                  60                  


Tyr Lys Ile Gly Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala Val 
65                  70                  75                  80  


Val Ala Asn Asn Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met Leu 
                85                  90                  95      


Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala Asp 
            100                 105                 110         


Gly Asn Asp Asn Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp Ile 
        115                 120                 125             


Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val Asn 
    130                 135                 140                 


Asn Ile Ser Gly Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe Ser 
145                 150                 155                 160 


Thr Val Tyr Thr Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg Ala 
                165                 170                 175     


Ala Phe Asn Asn Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln Tyr 
            180                 185                 190         


Asp Glu Phe Asp Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe Gly 
        195                 200                 205             


Gln Ala Phe Phe Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr Gly 
    210                 215                 220                 


Asn Glu Cys Tyr Asp Ile Leu Ala Leu Leu Ser Gly Leu Ala His Trp 
225                 230                 235                 240 


Val Val Ala Asn Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp Leu 
                245                 250                 255     


Tyr Asn Leu Asp Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu Asn 
            260                 265                 270         


Tyr Leu Tyr Asp Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser Lys 
        275                 280                 285             


Asn Ser Ala Ala Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile Asn 
    290                 295                 300                 


Pro Ala Glu Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu 
305                 310                 315                 320 


Gln Lys Asn Leu Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met Leu 
                325                 330                 335     


Asp Arg Lys Asp Met Ser Glu Ile Arg Lys Asn His Lys Val Phe Asp 
            340                 345                 350         


Ser Ile Arg Thr Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr Arg 
        355                 360                 365             


Tyr Tyr Ile Glu Glu Asp Ala Lys Val Ala Ala Ala Asn Lys Ser Leu 
    370                 375                 380                 


Pro Asp Asn Glu Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile Asn 
385                 390                 395                 400 


Leu Arg Gly Ser Phe Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr Asp 
                405                 410                 415     


Glu Ala Asn Arg Ile Trp Arg Lys Leu Glu Asn Ile Met His Asn Ile 
            420                 425                 430         


Lys Glu Phe Arg Gly Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp Ala 
        435                 440                 445             


Pro Arg Leu Pro Arg Ile Leu Pro Ala Gly Arg Asp Val Ser Ala Phe 
    450                 455                 460                 


Ser Lys Leu Met Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu Ile 
465                 470                 475                 480 


Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln Ser 
                485                 490                 495     


Phe Leu Lys Val Met Pro Leu Ile Gly Val Asn Ala Lys Phe Val Glu 
            500                 505                 510         


Glu Tyr Ala Phe Phe Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu Arg 
        515                 520                 525             


Leu Ile Lys Ser Phe Ala Arg Met Gly Glu Pro Ile Ala Asp Ala Arg 
    530                 535                 540                 


Arg Ala Met Tyr Ile Asp Ala Ile Arg Ile Leu Gly Thr Asn Leu Ser 
545                 550                 555                 560 


Tyr Asp Glu Leu Lys Ala Leu Ala Asp Thr Phe Ser Leu Asp Glu Asn 
                565                 570                 575     


Gly Asn Lys Leu Lys Lys Gly Lys His Gly Met Arg Asn Phe Ile Ile 
            580                 585                 590         


Asn Asn Val Ile Ser Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr Gly 
        595                 600                 605             


Asp Pro Ala His Leu His Glu Ile Ala Lys Asn Glu Ala Val Val Lys 
    610                 615                 620                 


Phe Val Leu Gly Arg Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln Asn 
625                 630                 635                 640 


Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys Asp 
                645                 650                 655     


Lys Gly Lys Ser Val Ser Glu Lys Val Asp Ala Leu Thr Lys Ile Ile 
            660                 665                 670         


Thr Gly Met Asn Tyr Asp Gln Phe Asp Lys Lys Arg Ser Val Ile Glu 
        675                 680                 685             


Asp Thr Gly Arg Glu Asn Ala Glu Arg Glu Lys Phe Lys Lys Ile Ile 
    690                 695                 700                 


Ser Leu Tyr Leu Thr Val Ile Tyr His Ile Leu Lys Asn Ile Val Asn 
705                 710                 715                 720 


Ile Asn Ala Arg Tyr Val Ile Gly Phe His Cys Val Glu Arg Asp Ala 
                725                 730                 735     


Gln Leu Tyr Lys Glu Lys Gly Tyr Asp Ile Asn Leu Lys Lys Leu Glu 
            740                 745                 750         


Glu Lys Gly Phe Ser Ser Val Thr Lys Leu Cys Ala Gly Ile Asp Glu 
        755                 760                 765             


Thr Ala Pro Asp Lys Arg Lys Asp Val Glu Lys Glu Met Ala Glu Arg 
    770                 775                 780                 


Ala Lys Glu Ser Ile Asp Ser Leu Glu Ser Ala Asn Pro Lys Leu Tyr 
785                 790                 795                 800 


Ala Asn Tyr Ile Lys Tyr Ser Asp Glu Lys Lys Ala Glu Glu Phe Thr 
                805                 810                 815     


Arg Gln Ile Asn Arg Glu Lys Ala Lys Thr Ala Leu Asn Ala Tyr Leu 
            820                 825                 830         


Arg Asn Thr Lys Trp Asn Val Ile Ile Arg Glu Asp Leu Leu Arg Ile 
        835                 840                 845             


Asp Asn Lys Thr Cys Thr Leu Phe Ala Asn Lys Ala Val Ala Leu Glu 
    850                 855                 860                 


Val Ala Arg Tyr Val His Ala Tyr Ile Asn Asp Ile Ala Glu Val Asn 
865                 870                 875                 880 


Ser Tyr Phe Gln Leu Tyr His Tyr Ile Met Gln Arg Ile Ile Met Asn 
                885                 890                 895     


Glu Arg Tyr Glu Lys Ser Ser Gly Lys Val Ser Glu Tyr Phe Asp Ala 
            900                 905                 910         


Val Asn Asp Glu Lys Lys Tyr Asn Asp Arg Leu Leu Lys Leu Leu Cys 
        915                 920                 925             


Val Pro Phe Gly Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
    930                 935                 940                 


Ala Leu Phe Asp Arg Asn Glu Ala Ala Lys Phe Asp Lys Glu Lys Lys 
945                 950                 955                 960 


Lys Val Ser Gly Asn Ser 
                965     


<210>  298
<211>  966
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasRx/Cas13d

<400>  298

Ile Glu Lys Lys Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser Thr 
1               5                   10                  15      


Leu Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly Ser 
            20                  25                  30          


Asp Ala Arg Leu Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser Val 
        35                  40                  45              


Asn Glu Gly Glu Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala Gly 
    50                  55                  60                  


Tyr Lys Ile Gly Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala Val 
65                  70                  75                  80  


Val Ala Asn Asn Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met Leu 
                85                  90                  95      


Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala Asp 
            100                 105                 110         


Gly Asn Asp Asn Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp Ile 
        115                 120                 125             


Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val Asn 
    130                 135                 140                 


Asn Ile Ser Gly Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe Ser 
145                 150                 155                 160 


Thr Val Tyr Thr Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg Ala 
                165                 170                 175     


Ala Phe Asn Asn Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln Tyr 
            180                 185                 190         


Asp Glu Phe Asp Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe Gly 
        195                 200                 205             


Gln Ala Phe Phe Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr Gly 
    210                 215                 220                 


Asn Glu Cys Tyr Asp Ile Leu Ala Leu Leu Ser Gly Leu Arg His Trp 
225                 230                 235                 240 


Val Val His Asn Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp Leu 
                245                 250                 255     


Tyr Asn Leu Asp Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu Asn 
            260                 265                 270         


Tyr Leu Tyr Asp Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser Lys 
        275                 280                 285             


Asn Ser Ala Ala Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile Asn 
    290                 295                 300                 


Pro Ala Glu Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu 
305                 310                 315                 320 


Gln Lys Asn Leu Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met Leu 
                325                 330                 335     


Asp Arg Lys Asp Met Ser Glu Ile Arg Lys Asn His Lys Val Phe Asp 
            340                 345                 350         


Ser Ile Arg Thr Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr Arg 
        355                 360                 365             


Tyr Tyr Ile Glu Glu Asp Ala Lys Val Ala Ala Ala Asn Lys Ser Leu 
    370                 375                 380                 


Pro Asp Asn Glu Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile Asn 
385                 390                 395                 400 


Leu Arg Gly Ser Phe Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr Asp 
                405                 410                 415     


Glu Ala Asn Arg Ile Trp Arg Lys Leu Glu Asn Ile Met His Asn Ile 
            420                 425                 430         


Lys Glu Phe Arg Gly Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp Ala 
        435                 440                 445             


Pro Arg Leu Pro Arg Ile Leu Pro Ala Gly Arg Asp Val Ser Ala Phe 
    450                 455                 460                 


Ser Lys Leu Met Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu Ile 
465                 470                 475                 480 


Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln Ser 
                485                 490                 495     


Phe Leu Lys Val Met Pro Leu Ile Gly Val Asn Ala Lys Phe Val Glu 
            500                 505                 510         


Glu Tyr Ala Phe Phe Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu Arg 
        515                 520                 525             


Leu Ile Lys Ser Phe Ala Arg Met Gly Glu Pro Ile Ala Asp Ala Arg 
    530                 535                 540                 


Arg Ala Met Tyr Ile Asp Ala Ile Arg Ile Leu Gly Thr Asn Leu Ser 
545                 550                 555                 560 


Tyr Asp Glu Leu Lys Ala Leu Ala Asp Thr Phe Ser Leu Asp Glu Asn 
                565                 570                 575     


Gly Asn Lys Leu Lys Lys Gly Lys His Gly Met Arg Asn Phe Ile Ile 
            580                 585                 590         


Asn Asn Val Ile Ser Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr Gly 
        595                 600                 605             


Asp Pro Ala His Leu His Glu Ile Ala Lys Asn Glu Ala Val Val Lys 
    610                 615                 620                 


Phe Val Leu Gly Arg Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln Asn 
625                 630                 635                 640 


Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys Asp 
                645                 650                 655     


Lys Gly Lys Ser Val Ser Glu Lys Val Asp Ala Leu Thr Lys Ile Ile 
            660                 665                 670         


Thr Gly Met Asn Tyr Asp Gln Phe Asp Lys Lys Arg Ser Val Ile Glu 
        675                 680                 685             


Asp Thr Gly Arg Glu Asn Ala Glu Arg Glu Lys Phe Lys Lys Ile Ile 
    690                 695                 700                 


Ser Leu Tyr Leu Thr Val Ile Tyr His Ile Leu Lys Asn Ile Val Asn 
705                 710                 715                 720 


Ile Asn Ala Arg Tyr Val Ile Gly Phe His Cys Val Glu Arg Asp Ala 
                725                 730                 735     


Gln Leu Tyr Lys Glu Lys Gly Tyr Asp Ile Asn Leu Lys Lys Leu Glu 
            740                 745                 750         


Glu Lys Gly Phe Ser Ser Val Thr Lys Leu Cys Ala Gly Ile Asp Glu 
        755                 760                 765             


Thr Ala Pro Asp Lys Arg Lys Asp Val Glu Lys Glu Met Ala Glu Arg 
    770                 775                 780                 


Ala Lys Glu Ser Ile Asp Ser Leu Glu Ser Ala Asn Pro Lys Leu Tyr 
785                 790                 795                 800 


Ala Asn Tyr Ile Lys Tyr Ser Asp Glu Lys Lys Ala Glu Glu Phe Thr 
                805                 810                 815     


Arg Gln Ile Asn Arg Glu Lys Ala Lys Thr Ala Leu Asn Ala Tyr Leu 
            820                 825                 830         


Arg Asn Thr Lys Trp Asn Val Ile Ile Arg Glu Asp Leu Leu Arg Ile 
        835                 840                 845             


Asp Asn Lys Thr Cys Thr Leu Phe Arg Asn Lys Ala Val His Leu Glu 
    850                 855                 860                 


Val Ala Arg Tyr Val His Ala Tyr Ile Asn Asp Ile Ala Glu Val Asn 
865                 870                 875                 880 


Ser Tyr Phe Gln Leu Tyr His Tyr Ile Met Gln Arg Ile Ile Met Asn 
                885                 890                 895     


Glu Arg Tyr Glu Lys Ser Ser Gly Lys Val Ser Glu Tyr Phe Asp Ala 
            900                 905                 910         


Val Asn Asp Glu Lys Lys Tyr Asn Asp Arg Leu Leu Lys Leu Leu Cys 
        915                 920                 925             


Val Pro Phe Gly Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
    930                 935                 940                 


Ala Leu Phe Asp Arg Asn Glu Ala Ala Lys Phe Asp Lys Glu Lys Lys 
945                 950                 955                 960 


Lys Val Ser Gly Asn Ser 
                965     


<210>  299
<211>  877
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cas13d (contig tpg|DJXD01000002.1

<400>  299

Met Lys Lys Gln Lys Ser Lys Lys Thr Val Ser Lys Thr Ser Gly Leu 
1               5                   10                  15      


Lys Glu Ala Leu Ser Val Gln Gly Thr Val Ile Met Thr Ser Phe Gly 
            20                  25                  30          


Lys Gly Asn Met Ala Asn Leu Ser Tyr Lys Ile Pro Ser Ser Gln Lys 
        35                  40                  45              


Pro Gln Asn Leu Asn Ser Ser Ala Gly Leu Lys Asn Val Glu Val Ser 
    50                  55                  60                  


Gly Lys Lys Ile Lys Phe Gln Gly Arg His Pro Lys Ile Ala Thr Thr 
65                  70                  75                  80  


Asp Asn Pro Leu Phe Lys Pro Gln Pro Gly Met Asp Leu Leu Cys Leu 
                85                  90                  95      


Lys Asp Lys Leu Glu Met His Tyr Phe Gly Lys Thr Phe Asp Asp Asn 
            100                 105                 110         


Ile His Ile Gln Leu Ile Tyr Gln Ile Leu Asp Ile Glu Lys Ile Leu 
        115                 120                 125             


Ala Val His Val Asn Asn Ile Val Phe Thr Leu Asp Asn Val Leu His 
    130                 135                 140                 


Pro Gln Lys Glu Glu Leu Thr Glu Asp Phe Ile Gly Ala Gly Gly Trp 
145                 150                 155                 160 


Arg Ile Asn Leu Asp Tyr Gln Thr Leu Arg Gly Gln Thr Asn Lys Tyr 
                165                 170                 175     


Asp Arg Phe Lys Asn Tyr Ile Lys Arg Lys Glu Leu Leu Tyr Phe Gly 
            180                 185                 190         


Glu Ala Phe Tyr His Glu Asn Glu Arg Arg Tyr Glu Glu Asp Ile Phe 
        195                 200                 205             


Ala Ile Leu Thr Leu Leu Ser Ala Leu Arg Gln Phe Cys Phe His Ser 
    210                 215                 220                 


Asp Leu Ser Ser Asp Glu Ser Asp His Val Asn Ser Phe Trp Leu Tyr 
225                 230                 235                 240 


Gln Leu Glu Asp Gln Leu Ser Asp Glu Phe Lys Glu Thr Leu Ser Ile 
                245                 250                 255     


Leu Trp Glu Glu Val Thr Glu Arg Ile Asp Ser Glu Phe Leu Lys Thr 
            260                 265                 270         


Asn Thr Val Asn Leu His Ile Leu Cys His Val Phe Pro Lys Glu Ser 
        275                 280                 285             


Lys Glu Thr Ile Val Arg Ala Tyr Tyr Glu Phe Leu Ile Lys Lys Ser 
    290                 295                 300                 


Phe Lys Asn Met Gly Phe Ser Ile Lys Lys Leu Arg Glu Ile Met Leu 
305                 310                 315                 320 


Glu Gln Ser Asp Leu Lys Ser Phe Lys Glu Asp Lys Tyr Asn Ser Val 
                325                 330                 335     


Arg Ala Lys Leu Tyr Lys Leu Phe Asp Phe Ile Ile Thr Tyr Tyr Tyr 
            340                 345                 350         


Asp His His Ala Phe Glu Lys Glu Ala Leu Val Ser Ser Leu Arg Ser 
        355                 360                 365             


Ser Leu Thr Glu Glu Asn Lys Glu Glu Ile Tyr Ile Lys Thr Ala Arg 
    370                 375                 380                 


Thr Leu Ala Ser Ala Leu Gly Ala Asp Phe Lys Lys Ala Ala Ala Asp 
385                 390                 395                 400 


Val Asn Ala Lys Asn Ile Arg Asp Tyr Gln Lys Lys Ala Asn Asp Tyr 
                405                 410                 415     


Arg Ile Ser Phe Glu Asp Ile Lys Ile Gly Asn Thr Gly Ile Gly Tyr 
            420                 425                 430         


Phe Ser Glu Leu Ile Tyr Met Leu Thr Leu Leu Leu Asp Gly Lys Glu 
        435                 440                 445             


Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Ile 
    450                 455                 460                 


Ser Phe Ile Asp Ile Leu Lys Lys Leu Asn Leu Glu Phe Lys Phe Lys 
465                 470                 475                 480 


Pro Glu Tyr Ala Asp Phe Phe Asn Met Thr Asn Cys Arg Tyr Thr Leu 
                485                 490                 495     


Glu Glu Leu Arg Val Ile Asn Ser Ile Ala Arg Met Gln Lys Pro Ser 
            500                 505                 510         


Ala Asp Ala Arg Lys Ile Met Tyr Arg Asp Ala Leu Arg Ile Leu Gly 
        515                 520                 525             


Met Asp Asn Arg Pro Asp Glu Glu Ile Asp Arg Glu Leu Glu Arg Thr 
    530                 535                 540                 


Met Pro Val Gly Ala Asp Gly Lys Phe Ile Lys Gly Lys Gln Gly Phe 
545                 550                 555                 560 


Arg Asn Phe Ile Ala Ser Asn Val Ile Glu Ser Ser Arg Phe His Tyr 
                565                 570                 575     


Leu Val Arg Tyr Asn Asn Pro His Lys Thr Arg Thr Leu Val Lys Asn 
            580                 585                 590         


Pro Asn Val Val Lys Phe Val Leu Glu Gly Ile Pro Glu Thr Gln Ile 
        595                 600                 605             


Lys Arg Tyr Phe Asp Val Cys Lys Gly Gln Glu Ile Pro Pro Thr Ser 
    610                 615                 620                 


Asp Lys Ser Ala Gln Ile Asp Val Leu Ala Arg Ile Ile Ser Ser Val 
625                 630                 635                 640 


Asp Tyr Lys Ile Phe Glu Asp Val Pro Gln Ser Ala Lys Ile Asn Lys 
                645                 650                 655     


Asp Asp Pro Ser Arg Asn Phe Ser Asp Ala Leu Lys Lys Gln Arg Tyr 
            660                 665                 670         


Gln Ala Ile Val Ser Leu Tyr Leu Thr Val Met Tyr Leu Ile Thr Lys 
        675                 680                 685             


Asn Leu Val Tyr Val Asn Ser Arg Tyr Val Ile Ala Phe His Cys Leu 
    690                 695                 700                 


Glu Arg Asp Ala Phe Leu His Gly Val Thr Leu Pro Lys Met Asn Lys 
705                 710                 715                 720 


Lys Ile Val Tyr Ser Gln Leu Thr Thr His Leu Leu Thr Asp Lys Asn 
                725                 730                 735     


Tyr Thr Thr Tyr Gly His Leu Lys Asn Gln Lys Gly His Arg Lys Trp 
            740                 745                 750         


Tyr Val Leu Val Lys Asn Asn Leu Gln Asn Ser Asp Ile Thr Ala Val 
        755                 760                 765             


Ser Ser Phe Arg Asn Ile Val Ala His Ile Ser Val Val Arg Asn Ser 
    770                 775                 780                 


Asn Glu Tyr Ile Ser Gly Ile Gly Glu Leu His Ser Tyr Phe Glu Leu 
785                 790                 795                 800 


Tyr His Tyr Leu Val Gln Ser Met Ile Ala Lys Asn Asn Trp Tyr Asp 
                805                 810                 815     


Thr Ser His Gln Pro Lys Thr Ala Glu Tyr Leu Asn Asn Leu Lys Lys 
            820                 825                 830         


His His Thr Tyr Cys Lys Asp Phe Val Lys Ala Tyr Cys Ile Pro Phe 
        835                 840                 845             


Gly Tyr Val Val Pro Arg Tyr Lys Asn Leu Thr Ile Asn Glu Leu Phe 
    850                 855                 860                 


Asp Arg Asn Asn Pro Asn Pro Glu Pro Lys Glu Glu Val 
865                 870                 875         


<210>  300
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Cas13d (contig tpg|DJXD01000002.1

<400>  300
caactacaac cccgtaaaaa tacggggttc tgaaac                                 36


<210>  301
<211>  1027
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  contig emb|OBLI01020244

<400>  301

Met Ala Lys Lys Ile Thr Ala Lys Gln Arg Arg Glu Glu Arg Glu Arg 
1               5                   10                  15      


Gln Asn Lys Gln Lys Trp Ala Lys Lys Gln Ala Asp Ala Thr Ala Val 
            20                  25                  30          


Phe Glu Cys Glu Ala Asp Ile Lys Pro Ala Asp Ser Lys Asp Glu Asp 
        35                  40                  45              


Cys Thr Asn Ile Tyr Ile Lys Arg Glu Lys Lys Lys Thr Gln Ala Lys 
    50                  55                  60                  


Ala Met Gly Leu Lys Thr Val Leu Gly Phe Asp Asn Lys Ile Ala Ile 
65                  70                  75                  80  


Ala Ser Phe Met Ser Ser Lys Asp Ser Lys Ser Ser His Ile Glu Arg 
                85                  90                  95      


Ile Thr Asp Pro Asn Gly Lys Thr Ile Arg Glu Asp Val Arg Met Phe 
            100                 105                 110         


Asp Ser Asn Val Asp Glu Cys Ser Ile Asn Leu Glu Lys Arg Met Thr 
        115                 120                 125             


Val Glu Glu Arg Gln Lys Asp Gly Thr Ile Lys Lys Asp Glu Lys Asp 
    130                 135                 140                 


Val Lys Ser Thr Ile Cys Asn Pro Tyr Ser Asn Glu Cys Gly Lys Asp 
145                 150                 155                 160 


Tyr Ile Gly Ile Lys Ser Val Ala Glu Glu Leu Phe Phe Gly Arg Thr 
                165                 170                 175     


Phe Pro Asn Asp Asn Leu Arg Val Gln Ile Ala Tyr Asn Ile Phe Asp 
            180                 185                 190         


Ile Gln Lys Ile Leu Gly Thr Tyr Ile Asn Asn Ile Ile Tyr Ser Phe 
        195                 200                 205             


Tyr Asn Leu Ser Arg Asp Glu Ser Gln Ser Asp Asn Asp Val Ile Gly 
    210                 215                 220                 


Thr Leu Tyr Met Leu Lys Asp Phe Asp Gly Gln Lys Glu Thr Asp Thr 
225                 230                 235                 240 


Phe Arg Gln Ala Arg Ala Leu Leu Glu Arg Thr Glu Ala Tyr Tyr Ser 
                245                 250                 255     


Tyr Phe Asp Asn Val Phe Lys Lys Ile Asp Lys Asn Lys Lys Lys Ser 
            260                 265                 270         


Asp Asp Cys Lys Arg Glu Arg Asn Glu Ile Leu Arg Tyr Asn Phe Asn 
        275                 280                 285             


Val Leu Arg Val Leu Ser Phe Leu Arg Gln Ile Cys Ala His Ala Gln 
    290                 295                 300                 


Val Lys Ile Ser Asn Glu His Asp Arg Glu Lys Gly Gly Gly Leu Val 
305                 310                 315                 320 


Asp Ser Leu Asp Ala Leu Phe Asn Ile Ser Arg Phe Phe Asp Ala Val 
                325                 330                 335     


Ala Pro Glu Leu Asn Glu Val Ile Asn Ser Val Tyr Ser Lys Gly Ile 
            340                 345                 350         


Asp Asp Ile Asn Asp Asn Phe Val Lys Asn Gly Lys Asn Asn Phe Tyr 
        355                 360                 365             


Ile Leu Ser Lys Ile Tyr Pro Glu Val Ala Arg Glu Asp Leu Leu Arg 
    370                 375                 380                 


Glu Tyr Tyr Tyr Phe Val Val Ser Lys Glu Gly Asn Asn Ile Gly Ile 
385                 390                 395                 400 


Ser Thr Lys Lys Leu Lys Glu Ala Ile Ile Val Gln Asp Met Ser Tyr 
                405                 410                 415     


Ile Lys Ser Glu Asp Tyr Asp Thr Tyr Arg Asn Lys Leu Tyr Thr Val 
            420                 425                 430         


Leu Cys Phe Ile Leu Val Lys Glu Leu Asn Glu Arg Thr Thr Ile Arg 
        435                 440                 445             


Glu Gln Met Val Ala Asp Leu Arg Ala Asn Met Asn Gly Asp Ile Gly 
    450                 455                 460                 


Arg Glu Asp Ile Tyr Ser Lys Tyr Ala Lys Ile Ile Tyr Ala Gln Val 
465                 470                 475                 480 


Lys Pro Arg Phe Asp Thr Met Lys Ser Ala Phe Glu Glu Glu Ala Lys 
                485                 490                 495     


Asp Val Ile Val Pro Asp Lys Lys Lys Pro Val Lys Phe Ser His Gly 
            500                 505                 510         


Lys Leu Asp Lys Asn Glu Ile Glu Arg Phe Cys Ile Thr Ser Ala Asn 
        515                 520                 525             


Thr Asp Ser Val Ala Lys Ile Ile Tyr Phe Leu Cys Lys Phe Leu Asp 
    530                 535                 540                 


Gly Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Met Asn Lys Leu Asp 
545                 550                 555                 560 


Gly Ile Asn Asp Leu Ile Glu Thr Ala Glu Gln Cys Gly Ala Lys Val 
                565                 570                 575     


Glu Phe Val Asp Lys Phe Ser Val Leu Ser Asn Cys Glu Thr Ile Ser 
            580                 585                 590         


Asp Gln Ile Arg Ile Val Lys Ser Ile Ser Lys Met Lys Lys Glu Ile 
        595                 600                 605             


Ala Ile Asp Asn Asp Thr Ile Phe Leu Asp Ala Leu Glu Leu Leu Gly 
    610                 615                 620                 


Arg Lys Ile Asp Lys Tyr Lys Lys Asp Ala Thr Gly Lys Tyr Leu Lys 
625                 630                 635                 640 


Asp Glu Asn Gly Lys Tyr Leu Tyr Ser Lys Glu Tyr Asp Asp Phe Gln 
                645                 650                 655     


Tyr Met Phe Phe Lys Asp Ser His Arg Val Arg Asn Phe Ile Ser Asn 
            660                 665                 670         


Ser Val Ile Lys Ser Lys Trp Phe Ser Tyr Ile Val Arg Tyr Asn Gln 
        675                 680                 685             


Pro Ser Glu Cys Arg Ala Ile Met Lys Asn Lys Thr Leu Val Lys Phe 
    690                 695                 700                 


Ala Leu Asp Glu Leu Pro Asp Leu Gln Ile Gln Arg Tyr Phe Val Ala 
705                 710                 715                 720 


Leu Tyr Gly Asp Glu Asp Leu Pro Ser Tyr Gly Glu Met Arg Lys Ile 
                725                 730                 735     


Leu Leu Lys Lys Leu His Asp Phe Ser Ile Lys Gly Phe Leu Asp Glu 
            740                 745                 750         


Ile Val Leu Leu Ser Asp Leu Asp Met Glu Ser Gln Asp Lys Tyr Cys 
        755                 760                 765             


Glu Lys Glu Gln Lys Lys Ser Leu Phe Arg Leu Tyr Leu Thr Ile Ala 
    770                 775                 780                 


Tyr Leu Ile Thr Lys Ser Met Val Lys Ile Asn Thr Arg Phe Ser Ile 
785                 790                 795                 800 


Ala Cys Ala Thr Tyr Glu Arg Asp Tyr Ala Leu Leu Cys Ala Ser Asn 
                805                 810                 815     


Lys Gln Glu Arg Ala Trp Ser Ser Gly Ala Thr Ala Leu Ala Leu Thr 
            820                 825                 830         


Arg Arg Phe Leu Asn Gln Asp Lys Leu Ile Phe Glu Lys His Tyr Ala 
        835                 840                 845             


Arg Glu Gly Glu Ile Ser Lys Leu Pro Lys Glu Glu Arg Lys Ala Met 
    850                 855                 860                 


Arg Lys Val Asn Asp Gln Leu Leu Lys Arg Thr His Phe Ser Lys His 
865                 870                 875                 880 


Ser Tyr Cys Tyr Ile Val Asp Asn Val Asn Arg Leu Thr Gly Gly Glu 
                885                 890                 895     


Cys Arg Thr Asp Lys Arg Val Leu Pro Val Leu Asn Glu Lys Asn Asp 
            900                 905                 910         


Asn Ala Gly Ile Leu Leu Asp Phe Arg Lys Thr Ile Ala His Leu Asn 
        915                 920                 925             


Val Val His Lys Met Val Asp Tyr Val Asp Glu Ile Lys Gly Ile Thr 
    930                 935                 940                 


Ser Tyr Tyr Ala Phe Phe Cys Tyr Val Leu Gln Arg Met Leu Val Gly 
945                 950                 955                 960 


Asn Asn Leu Asn Glu Lys Asn Ala Ile Lys Glu Lys Tyr Ser Ala Thr 
                965                 970                 975     


Val Lys Ser Phe Gly Thr Tyr Ser Lys Asp Phe Met Trp Leu Ile Asn 
            980                 985                 990         


Leu Pro Phe Ala Tyr Asn Leu Pro  Arg Tyr Lys Asn Leu  Ser Asn Glu 
        995                 1000                 1005             


Gln Leu  Phe Tyr Asp Glu Glu  Glu Arg Asn Glu Thr  Glu Glu Gln 
    1010                 1015                 1020             


Ile Asp  Arg Leu 
    1025         


<210>  302
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasRx Direct Repeat

<400>  302
aacccctacc aactggtcgg ggtttgaaac                                        30


<210>  303
<211>  954
<212>  PRT
<213>  Eubacterium siraeum

<400>  303

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Pro Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Arg Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asp Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Lys Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Glu Ser Asp Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Phe Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  304
<211>  919
<212>  PRT
<213>  Unknown

<220>  
<223>  Ruminococcus sp.

<400>  304

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Gln Leu Gly Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Asp 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Gly Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  305
<211>  918
<212>  PRT
<213>  Ruminococcus bicirculans

<400>  305

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  306
<211>  922
<212>  PRT
<213>  Unknown

<220>  
<223>  Ruminococcus sp., isolate 2789STDY5608892 CasM

<400>  306

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asn Glu Ser Ser Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Gly 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  307
<211>  922
<212>  PRT
<213>  Unknown

<220>  
<223>  Ruminococcus sp. CAG:57 CasM

<400>  307

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asp Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asn Glu Ser Ser Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Gly 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  308
<211>  933
<212>  PRT
<213>  Ruminococcus flavefaciens

<400>  308

Met Lys Lys Lys Met Ser Leu Arg Glu Lys Arg Glu Ala Glu Lys Gln 
1               5                   10                  15      


Ala Lys Lys Ala Ala Tyr Ser Ala Ala Ser Lys Asn Thr Asp Ser Lys 
            20                  25                  30          


Pro Ala Glu Lys Lys Ala Glu Thr Pro Lys Pro Ala Glu Ile Ile Ser 
        35                  40                  45              


Asp Asn Ser Arg Asn Lys Thr Ala Val Lys Ala Ala Gly Leu Lys Ser 
    50                  55                  60                  


Thr Ile Ile Ser Gly Asp Lys Leu Tyr Met Thr Ser Phe Gly Lys Gly 
65                  70                  75                  80  


Asn Ala Ala Val Ile Glu Gln Lys Ile Asp Ile Asn Asp Tyr Ser Phe 
                85                  90                  95      


Ser Ala Met Lys Asp Thr Pro Ser Leu Glu Val Asp Lys Ala Glu Ser 
            100                 105                 110         


Lys Glu Ile Ser Phe Ser Ser His His Pro Phe Val Lys Asn Asp Lys 
        115                 120                 125             


Leu Thr Thr Tyr Asn Pro Leu Tyr Gly Gly Lys Asp Asn Pro Glu Lys 
    130                 135                 140                 


Pro Val Gly Arg Asp Met Leu Gly Leu Lys Asp Lys Leu Glu Glu Arg 
145                 150                 155                 160 


Tyr Phe Gly Cys Thr Phe Asn Asp Asn Leu His Ile Gln Ile Ile Tyr 
                165                 170                 175     


Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val His Ser Ala Asn Ile 
            180                 185                 190         


Thr Thr Ala Leu Asp His Met Val Asp Glu Asp Asp Glu Lys Tyr Leu 
        195                 200                 205             


Asn Ser Asp Tyr Ile Gly Tyr Met Asn Thr Ile Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Met Asp Pro Ser Lys Asn Ser Ser Leu Ser Pro Lys Asp Arg Lys 
225                 230                 235                 240 


Asn Ile Asp Asn Ser Arg Ala Lys Phe Glu Lys Leu Leu Ser Thr Lys 
                245                 250                 255     


Arg Leu Gly Tyr Phe Gly Phe Asp Tyr Asp Ala Asn Gly Lys Asp Lys 
            260                 265                 270         


Lys Lys Asn Glu Glu Ile Lys Lys Arg Leu Tyr His Leu Thr Ala Phe 
        275                 280                 285             


Ala Gly Gln Leu Arg Gln Trp Ser Phe His Ser Ala Gly Asn Tyr Pro 
    290                 295                 300                 


Arg Thr Trp Leu Tyr Lys Leu Asp Ser Leu Asp Lys Glu Tyr Leu Asp 
305                 310                 315                 320 


Thr Leu Asp His Tyr Phe Asp Lys Arg Phe Asn Asp Ile Asn Asp Asp 
                325                 330                 335     


Phe Val Thr Lys Asn Ala Thr Asn Leu Tyr Ile Leu Lys Glu Val Phe 
            340                 345                 350         


Pro Glu Ala Asn Phe Lys Asp Ile Ala Asp Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Ile Lys Ser His Lys Asn Met Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Glu Cys Asp Gly Ala Asp Arg Ile Lys Glu Gln Asp 
385                 390                 395                 400 


Met Asp Ser Val Arg Ser Lys Leu Tyr Lys Leu Ile Asp Phe Cys Ile 
                405                 410                 415     


Phe Lys Tyr Tyr His Glu Phe Pro Glu Leu Ser Glu Lys Asn Val Asp 
            420                 425                 430         


Ile Leu Arg Ala Ala Val Ser Asp Thr Lys Lys Asp Asn Leu Tyr Ser 
        435                 440                 445             


Asp Glu Ala Ala Arg Leu Trp Ser Ile Phe Lys Glu Lys Phe Leu Gly 
    450                 455                 460                 


Phe Cys Asp Lys Ile Val Val Trp Val Thr Gly Glu His Glu Lys Asp 
465                 470                 475                 480 


Ile Thr Ser Val Ile Asp Lys Asp Ala Tyr Arg Asn Arg Ser Asn Val 
                485                 490                 495     


Ser Tyr Phe Ser Lys Leu Met Tyr Ala Met Cys Phe Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn 
        515                 520                 525             


Ile Ala Asn Gln Ile Lys Thr Ala Lys Glu Leu Gly Ile Asn Thr Ala 
    530                 535                 540                 


Phe Val Lys Asn Tyr Asp Phe Phe Asn His Ser Glu Lys Tyr Val Asp 
545                 550                 555                 560 


Glu Leu Asn Ile Val Lys Asn Ile Ala Arg Met Lys Lys Pro Ser Ser 
                565                 570                 575     


Asn Ala Lys Lys Ala Met Tyr His Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Pro Glu Asp Met Asp Glu Lys Ala Leu Asp Glu Glu Leu Asp Leu Ile 
        595                 600                 605             


Leu Glu Lys Lys Thr Asp Pro Val Thr Gly Lys Pro Leu Lys Gly Lys 
    610                 615                 620                 


Asn Pro Leu Arg Asn Phe Ile Ala Asn Asn Val Ile Glu Asn Ser Arg 
625                 630                 635                 640 


Phe Ile Tyr Leu Ile Lys Phe Cys Asn Pro Glu Asn Val Arg Lys Ile 
                645                 650                 655     


Val Asn Asn Thr Lys Val Thr Glu Phe Val Leu Lys Arg Ile Pro Asp 
            660                 665                 670         


Ala Gln Ile Glu Arg Tyr Tyr Lys Ser Cys Thr Asp Ser Glu Met Asn 
        675                 680                 685             


Pro Pro Thr Glu Lys Lys Ile Thr Glu Leu Ala Gly Lys Leu Lys Asp 
    690                 695                 700                 


Met Asn Phe Gly Asn Phe Arg Asn Val Arg Gln Ser Ala Lys Glu Asn 
705                 710                 715                 720 


Met Glu Lys Glu Arg Phe Lys Ala Val Ile Gly Leu Tyr Leu Thr Val 
                725                 730                 735     


Val Tyr Arg Val Val Lys Asn Leu Val Asp Val Asn Ser Arg Tyr Ile 
            740                 745                 750         


Met Ala Phe His Ser Leu Glu Arg Asp Ser Gln Leu Tyr Asn Val Ser 
        755                 760                 765             


Val Asp Asn Asp Tyr Leu Ala Leu Thr Asp Thr Leu Val Lys Glu Gly 
    770                 775                 780                 


Asp Asn Ser Arg Ser Arg Tyr Leu Ala Gly Asn Lys Arg Leu Arg Asp 
785                 790                 795                 800 


Cys Val Lys Gln Asp Ile Asp Asn Ala Lys Lys Trp Phe Val Ser Asp 
                805                 810                 815     


Lys Tyr Asn Ser Ile Thr Lys Tyr Arg Asn Asn Val Ala His Leu Thr 
            820                 825                 830         


Ala Val Arg Asn Cys Ala Glu Phe Ile Gly Asp Ile Thr Lys Ile Asp 
        835                 840                 845             


Ser Tyr Phe Ala Leu Tyr His Tyr Leu Ile Gln Arg Gln Leu Ala Lys 
    850                 855                 860                 


Gly Leu Asp His Glu Arg Ser Gly Phe Asp Arg Asn Tyr Pro Gln Tyr 
865                 870                 875                 880 


Ala Pro Leu Phe Lys Trp His Thr Tyr Val Lys Asp Val Val Lys Ala 
                885                 890                 895     


Leu Asn Ala Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Asp Ala Leu Phe Asp Arg Asn Glu Ile Lys Lys Asn Asp Gly Glu 
        915                 920                 925             


Lys Lys Ser Asp Asp 
    930             


<210>  309
<211>  944
<212>  PRT
<213>  Ruminococcus albus

<400>  309

Met Ala Lys Lys Ser Lys Gly Met Ser Leu Arg Glu Lys Arg Glu Leu 
1               5                   10                  15      


Glu Lys Gln Lys Arg Ile Gln Lys Ala Ala Val Asn Ser Val Asn Asp 
            20                  25                  30          


Thr Pro Glu Lys Thr Glu Glu Ala Asn Val Val Ser Val Asn Val Arg 
        35                  40                  45              


Thr Ser Ala Glu Asn Lys His Ser Lys Lys Ser Ala Ala Lys Ala Leu 
    50                  55                  60                  


Gly Leu Lys Ser Gly Leu Val Ile Gly Asp Glu Leu Tyr Leu Thr Ser 
65                  70                  75                  80  


Phe Gly Arg Gly Asn Glu Ala Lys Leu Glu Lys Lys Ile Ser Gly Asp 
                85                  90                  95      


Thr Val Glu Lys Leu Gly Ile Gly Ala Phe Glu Val Ala Glu Arg Asp 
            100                 105                 110         


Glu Ser Thr Leu Thr Leu Glu Ser Gly Arg Ile Lys Asp Lys Thr Ala 
        115                 120                 125             


Arg Pro Lys Asp Pro Arg His Ile Thr Val Asp Thr Gln Gly Lys Phe 
    130                 135                 140                 


Lys Glu Asp Met Leu Gly Ile Arg Ser Val Leu Glu Lys Lys Ile Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Val Gln Leu Ala Tyr Asn Ile 
                165                 170                 175     


Leu Asp Val Glu Lys Ile Met Ala Gln Tyr Val Ser Asp Ile Val Tyr 
            180                 185                 190         


Met Leu His Asn Thr Asp Lys Thr Glu Arg Asn Asp Asn Leu Met Gly 
        195                 200                 205             


Tyr Met Ser Ile Arg Asn Thr Tyr Lys Thr Phe Cys Asp Thr Ser Asn 
    210                 215                 220                 


Leu Pro Asp Asp Thr Lys Gln Lys Val Glu Asn Gln Lys Arg Glu Phe 
225                 230                 235                 240 


Asp Lys Ile Ile Lys Ser Gly Arg Leu Gly Tyr Phe Gly Glu Ala Phe 
                245                 250                 255     


Met Val Asn Ser Gly Asn Ser Thr Lys Leu Arg Pro Glu Lys Glu Ile 
            260                 265                 270         


Tyr His Ile Phe Ala Leu Met Ala Ser Leu Arg Gln Ser Tyr Phe His 
        275                 280                 285             


Gly Tyr Val Lys Asp Thr Asp Tyr Gln Gly Thr Thr Trp Ala Tyr Thr 
    290                 295                 300                 


Leu Glu Asp Lys Leu Lys Gly Pro Ser His Glu Phe Arg Glu Thr Ile 
305                 310                 315                 320 


Asp Lys Ile Phe Asp Glu Gly Phe Ser Lys Ile Ser Lys Asp Phe Gly 
                325                 330                 335     


Lys Met Asn Lys Val Asn Leu Gln Ile Leu Glu Gln Met Ile Gly Glu 
            340                 345                 350         


Leu Tyr Gly Ser Ile Glu Arg Gln Asn Leu Thr Cys Asp Tyr Tyr Asp 
        355                 360                 365             


Phe Ile Gln Leu Lys Lys His Lys Tyr Leu Gly Phe Ser Ile Lys Arg 
    370                 375                 380                 


Leu Arg Glu Thr Met Leu Glu Thr Thr Pro Ala Glu Cys Tyr Lys Ala 
385                 390                 395                 400 


Glu Cys Tyr Asn Ser Glu Arg Gln Lys Leu Tyr Lys Leu Ile Asp Phe 
                405                 410                 415     


Leu Ile Tyr Asp Leu Tyr Tyr Asn Arg Lys Pro Ala Arg Ile Glu Glu 
            420                 425                 430         


Ile Val Asp Lys Leu Arg Glu Ser Val Asn Asp Glu Glu Lys Glu Ser 
        435                 440                 445             


Ile Tyr Ser Val Glu Ala Lys Tyr Val Tyr Glu Ser Leu Ser Lys Val 
    450                 455                 460                 


Leu Asp Lys Ser Leu Lys Asn Ser Val Ser Gly Glu Thr Ile Lys Asp 
465                 470                 475                 480 


Leu Gln Lys Arg Tyr Asp Asp Glu Thr Ala Asn Arg Ile Trp Asp Ile 
                485                 490                 495     


Ser Gln His Ser Ile Ser Gly Asn Val Asn Cys Phe Cys Lys Leu Ile 
            500                 505                 510         


Tyr Ile Met Thr Leu Met Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu 
        515                 520                 525             


Thr Thr Leu Val Asn Lys Phe Asp Asn Ile Ala Ser Phe Ile Asp Val 
    530                 535                 540                 


Met Asp Glu Leu Gly Leu Glu His Ser Phe Thr Asp Asn Tyr Lys Met 
545                 550                 555                 560 


Phe Ala Asp Ser Lys Ala Ile Cys Leu Asp Leu Gln Phe Ile Asn Ser 
                565                 570                 575     


Phe Ala Arg Met Ser Lys Ile Asp Asp Glu Lys Ser Lys Arg Gln Leu 
            580                 585                 590         


Phe Arg Asp Ala Leu Val Ile Leu Asp Ile Gly Asn Lys Asp Glu Thr 
        595                 600                 605             


Trp Ile Asn Asn Tyr Leu Asp Ser Asp Ile Phe Lys Leu Asp Lys Glu 
    610                 615                 620                 


Gly Asn Lys Leu Lys Gly Ala Arg His Asp Phe Arg Asn Phe Ile Ala 
625                 630                 635                 640 


Asn Asn Val Ile Lys Ser Ser Arg Phe Lys Tyr Leu Val Lys Tyr Ser 
                645                 650                 655     


Ser Ala Asp Gly Met Ile Lys Leu Lys Thr Asn Glu Lys Leu Ile Gly 
            660                 665                 670         


Phe Val Leu Asp Lys Leu Pro Glu Thr Gln Ile Asp Arg Tyr Tyr Glu 
        675                 680                 685             


Ser Cys Gly Leu Asp Asn Ala Val Val Asp Lys Lys Val Arg Ile Glu 
    690                 695                 700                 


Lys Leu Ser Gly Leu Ile Arg Asp Met Lys Phe Asp Asp Phe Ser Gly 
705                 710                 715                 720 


Val Lys Thr Ser Asn Lys Ala Gly Asp Asn Asp Lys Gln Asp Lys Ala 
                725                 730                 735     


Lys Tyr Gln Ala Ile Ile Ser Leu Tyr Leu Met Val Leu Tyr Gln Ile 
            740                 745                 750         


Val Lys Asn Met Ile Tyr Val Asn Ser Arg Tyr Val Ile Ala Phe His 
        755                 760                 765             


Cys Leu Glu Arg Asp Phe Gly Met Tyr Gly Lys Asp Phe Gly Lys Tyr 
    770                 775                 780                 


Tyr Gln Gly Cys Arg Lys Leu Thr Asp His Phe Ile Glu Glu Lys Tyr 
785                 790                 795                 800 


Met Lys Glu Gly Lys Leu Gly Cys Asn Lys Lys Val Gly Arg Tyr Leu 
                805                 810                 815     


Lys Asn Asn Ile Ser Cys Cys Thr Asp Gly Leu Ile Asn Thr Tyr Arg 
            820                 825                 830         


Asn Gln Val Asp His Phe Ala Val Val Arg Lys Ile Gly Asn Tyr Ala 
        835                 840                 845             


Ala Tyr Ile Lys Ser Ile Gly Ser Trp Phe Glu Leu Tyr His Tyr Val 
    850                 855                 860                 


Ile Gln Arg Ile Val Phe Asp Glu Tyr Arg Phe Ala Leu Asn Asn Thr 
865                 870                 875                 880 


Glu Ser Asn Tyr Lys Asn Ser Ile Ile Lys His His Thr Tyr Cys Lys 
                885                 890                 895     


Asp Met Val Lys Ala Leu Asn Thr Pro Phe Gly Tyr Asp Leu Pro Arg 
            900                 905                 910         


Tyr Lys Asn Leu Ser Ile Gly Asp Leu Phe Asp Arg Asn Asn Tyr Leu 
        915                 920                 925             


Asn Lys Thr Lys Glu Ser Ile Asp Ala Asn Ser Ser Ile Asp Ser Gln 
    930                 935                 940                 


<210>  310
<211>  967
<212>  PRT
<213>  Ruminococcus flavefaciens

<400>  310

Met Ile Glu Lys Lys Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser 
1               5                   10                  15      


Thr Leu Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly 
            20                  25                  30          


Ser Asp Ala Arg Leu Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser 
        35                  40                  45              


Val Asn Glu Gly Glu Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala 
    50                  55                  60                  


Gly Tyr Lys Ile Gly Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala 
65                  70                  75                  80  


Val Val Ala Asn Asn Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met 
                85                  90                  95      


Leu Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala 
            100                 105                 110         


Asp Gly Asn Asp Asn Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp 
        115                 120                 125             


Ile Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val 
    130                 135                 140                 


Asn Asn Ile Ser Gly Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe 
145                 150                 155                 160 


Ser Thr Val Tyr Thr Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg 
                165                 170                 175     


Ala Ala Phe Asn Asn Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln 
            180                 185                 190         


Tyr Asp Glu Phe Asp Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe 
        195                 200                 205             


Gly Gln Ala Phe Phe Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr 
    210                 215                 220                 


Gly Asn Glu Cys Tyr Asp Ile Leu Ala Leu Leu Ser Gly Leu Arg His 
225                 230                 235                 240 


Trp Val Val His Asn Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp 
                245                 250                 255     


Leu Tyr Asn Leu Asp Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu 
            260                 265                 270         


Asn Tyr Leu Tyr Asp Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser 
        275                 280                 285             


Lys Asn Ser Ala Ala Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile 
    290                 295                 300                 


Asn Pro Ala Glu Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys 
305                 310                 315                 320 


Glu Gln Lys Asn Leu Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met 
                325                 330                 335     


Leu Asp Arg Lys Asp Met Ser Glu Ile Arg Lys Asn His Lys Val Phe 
            340                 345                 350         


Asp Ser Ile Arg Thr Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr 
        355                 360                 365             


Arg Tyr Tyr Ile Glu Glu Asp Ala Lys Val Ala Ala Ala Asn Lys Ser 
    370                 375                 380                 


Leu Pro Asp Asn Glu Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile 
385                 390                 395                 400 


Asn Leu Arg Gly Ser Phe Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr 
                405                 410                 415     


Asp Glu Ala Asn Arg Ile Trp Arg Lys Leu Glu Asn Ile Met His Asn 
            420                 425                 430         


Ile Lys Glu Phe Arg Gly Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp 
        435                 440                 445             


Ala Pro Arg Leu Pro Arg Ile Leu Pro Ala Gly Arg Asp Val Ser Ala 
    450                 455                 460                 


Phe Ser Lys Leu Met Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu 
465                 470                 475                 480 


Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln 
                485                 490                 495     


Ser Phe Leu Lys Val Met Pro Leu Ile Gly Val Asn Ala Lys Phe Val 
            500                 505                 510         


Glu Glu Tyr Ala Phe Phe Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu 
        515                 520                 525             


Arg Leu Ile Lys Ser Phe Ala Arg Met Gly Glu Pro Ile Ala Asp Ala 
    530                 535                 540                 


Arg Arg Ala Met Tyr Ile Asp Ala Ile Arg Ile Leu Gly Thr Asn Leu 
545                 550                 555                 560 


Ser Tyr Asp Glu Leu Lys Ala Leu Ala Asp Thr Phe Ser Leu Asp Glu 
                565                 570                 575     


Asn Gly Asn Lys Leu Lys Lys Gly Lys His Gly Met Arg Asn Phe Ile 
            580                 585                 590         


Ile Asn Asn Val Ile Ser Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr 
        595                 600                 605             


Gly Asp Pro Ala His Leu His Glu Ile Ala Lys Asn Glu Ala Val Val 
    610                 615                 620                 


Lys Phe Val Leu Gly Arg Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln 
625                 630                 635                 640 


Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys 
                645                 650                 655     


Asp Lys Gly Lys Ser Val Ser Glu Lys Val Asp Ala Leu Thr Lys Ile 
            660                 665                 670         


Ile Thr Gly Met Asn Tyr Asp Gln Phe Asp Lys Lys Arg Ser Val Ile 
        675                 680                 685             


Glu Asp Thr Gly Arg Glu Asn Ala Glu Arg Glu Lys Phe Lys Lys Ile 
    690                 695                 700                 


Ile Ser Leu Tyr Leu Thr Val Ile Tyr His Ile Leu Lys Asn Ile Val 
705                 710                 715                 720 


Asn Ile Asn Ala Arg Tyr Val Ile Gly Phe His Cys Val Glu Arg Asp 
                725                 730                 735     


Ala Gln Leu Tyr Lys Glu Lys Gly Tyr Asp Ile Asn Leu Lys Lys Leu 
            740                 745                 750         


Glu Glu Lys Gly Phe Ser Ser Val Thr Lys Leu Cys Ala Gly Ile Asp 
        755                 760                 765             


Glu Thr Ala Pro Asp Lys Arg Lys Asp Val Glu Lys Glu Met Ala Glu 
    770                 775                 780                 


Arg Ala Lys Glu Ser Ile Asp Ser Leu Glu Ser Ala Asn Pro Lys Leu 
785                 790                 795                 800 


Tyr Ala Asn Tyr Ile Lys Tyr Ser Asp Glu Lys Lys Ala Glu Glu Phe 
                805                 810                 815     


Thr Arg Gln Ile Asn Arg Glu Lys Ala Lys Thr Ala Leu Asn Ala Tyr 
            820                 825                 830         


Leu Arg Asn Thr Lys Trp Asn Val Ile Ile Arg Glu Asp Leu Leu Arg 
        835                 840                 845             


Ile Asp Asn Lys Thr Cys Thr Leu Phe Arg Asn Lys Ala Val His Leu 
    850                 855                 860                 


Glu Val Ala Arg Tyr Val His Ala Tyr Ile Asn Asp Ile Ala Glu Val 
865                 870                 875                 880 


Asn Ser Tyr Phe Gln Leu Tyr His Tyr Ile Met Gln Arg Ile Ile Met 
                885                 890                 895     


Asn Glu Arg Tyr Glu Lys Ser Ser Gly Lys Val Ser Glu Tyr Phe Asp 
            900                 905                 910         


Ala Val Asn Asp Glu Lys Lys Tyr Asn Asp Arg Leu Leu Lys Leu Leu 
        915                 920                 925             


Cys Val Pro Phe Gly Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile 
    930                 935                 940                 


Glu Ala Leu Phe Asp Arg Asn Glu Ala Ala Lys Phe Asp Lys Glu Lys 
945                 950                 955                 960 


Lys Lys Val Ser Gly Asn Ser 
                965         


<210>  311
<211>  796
<212>  PRT
<213>  Unknown

<220>  
<223>  Ruminococcus sp., isolate 2789STDY5834894 CasM

<400>  311

Met Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser 
1               5                   10                  15      


Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg 
            20                  25                  30          


Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr 
        35                  40                  45              


Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile 
    50                  55                  60                  


Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr 
65                  70                  75                  80  


Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile Phe 
                85                  90                  95      


Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile 
            100                 105                 110         


Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu 
        115                 120                 125             


Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser 
    130                 135                 140                 


Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln 
145                 150                 155                 160 


Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr 
                165                 170                 175     


Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu 
            180                 185                 190         


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val 
        195                 200                 205             


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
    210                 215                 220                 


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
225                 230                 235                 240 


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
                245                 250                 255     


Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
            260                 265                 270         


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
        275                 280                 285             


Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu 
    290                 295                 300                 


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
305                 310                 315                 320 


Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
                325                 330                 335     


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
            340                 345                 350         


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
        355                 360                 365             


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
    370                 375                 380                 


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
385                 390                 395                 400 


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
                405                 410                 415     


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
            420                 425                 430         


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
        435                 440                 445             


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
    450                 455                 460                 


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
465                 470                 475                 480 


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
                485                 490                 495     


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
            500                 505                 510         


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
        515                 520                 525             


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
    530                 535                 540                 


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
545                 550                 555                 560 


Cys Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe 
                565                 570                 575     


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
            580                 585                 590         


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
        595                 600                 605             


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
    610                 615                 620                 


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
625                 630                 635                 640 


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
                645                 650                 655     


Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys 
            660                 665                 670         


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
        675                 680                 685             


Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
    690                 695                 700                 


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
705                 710                 715                 720 


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
                725                 730                 735     


Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp 
            740                 745                 750         


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
        755                 760                 765             


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
    770                 775                 780                 


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
785                 790                 795     


<210>  312
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RtcB homolog

<400>  312

Met Ile Val Leu Glu Ile Ile Gly Glu Arg Asn Thr Ala Val Val Tyr 
1               5                   10                  15      


Gly Glu Ile Ile Asp Glu Cys Ala Val Ser Gln Ile Glu Glu Ile Cys 
            20                  25                  30          


Asn His Pro Ala Phe Glu Asn Ser Arg Ile Arg Ile Met Pro Asp Cys 
        35                  40                  45              


His Ala Gly Lys Gly Cys Val Ile Gly Phe Thr Cys Val Thr Ser Asn 
    50                  55                  60                  


Arg Met Ile Val Pro Asn Ile Val Gly Val Asp Ile Gly Cys Gly Ile 
65                  70                  75                  80  


Leu Thr Thr Val Phe Thr Ala Asp Arg Glu Ile Asp Tyr Arg Ala Leu 
                85                  90                  95      


Asp Thr Phe Ile Arg Ser Asn Ile Pro Ser Gly Met Glu Ile His Asp 
            100                 105                 110         


Ser Val Ser Asp Thr Val Ala Glu Asn Thr Ala Leu Ile Ala Lys Val 
        115                 120                 125             


Asn Gly Ile Cys Asp Ala Ile Gly Glu Ser Ala Asp Val Asp Tyr His 
    130                 135                 140                 


Leu Arg Ser Ile Gly Thr Leu Gly Gly Gly Asn His Phe Ile Glu Ile 
145                 150                 155                 160 


Asp Arg Leu Asn Asn Gly Asn Tyr Ala Leu Thr Val His Thr Gly Ser 
                165                 170                 175     


Arg Asn Leu Gly Lys Arg Ile Cys Gly Tyr Phe Gln Ser Asn Ala Ser 
            180                 185                 190         


Val Ile Asp Thr Glu Leu Arg Arg Ser Ile Leu Leu Arg His Arg Ser 
        195                 200                 205             


Ala Thr Thr Ser Glu Glu His Glu Glu Ile Asp Arg Arg Ala Ala Gln 
    210                 215                 220                 


Ile Ala Pro Val Ser Lys Glu Leu Ala Phe Ile Thr Gly Glu Arg Tyr 
225                 230                 235                 240 


Asp Ser Tyr Ile Gly Cys Met Leu Asp Ala Lys Ala Leu Ala Ala Phe 
                245                 250                 255     


Asn Arg Thr Val Ile Ser Asp Arg Ile Met Ser Phe Leu Ala Asp Glu 
            260                 265                 270         


Tyr Gly Val Glu Ile Lys Asp Arg Phe Asp Thr Val His Asn Tyr Ile 
        275                 280                 285             


Asp Trp Tyr Asp Asp Thr His Thr Ser Val Val Ile Arg Lys Gly Ala 
    290                 295                 300                 


Ile Ser Ala Arg Lys Gly Glu Arg Ile Val Ile Pro Leu Asn Met Arg 
305                 310                 315                 320 


Asp Gly Ile Ile Ile Ala His Gly Arg Gly Asn Glu Glu Trp Asn Cys 
                325                 330                 335     


Ser Ala Pro His Gly Ser Gly Arg Ala Tyr Ser Arg Ser Asp Ala Arg 
            340                 345                 350         


Arg Thr Phe Thr Leu Glu Glu Tyr Val Glu Glu Met Asp Gly Val Asn 
        355                 360                 365             


Thr Trp Ser Val Ser Glu Ser Thr Ile Asp Glu Cys Pro Met Ala Tyr 
    370                 375                 380                 


Lys Pro Ser Glu Met Ile Ile Gly Ser Ile Gly Asp Thr Val Glu Ile 
385                 390                 395                 400 


Glu Ser Ile Ala His Thr Val Tyr Asn Phe Lys Ala 
                405                 410         


<210>  313
<211>  831
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  WYL Eubacterium siraeum + C-term NLS

<400>  313

Met Lys Lys Thr Glu Lys Phe Asp Asp Val Gln Ser Gly Tyr Glu Tyr 
1               5                   10                  15      


Lys Tyr Phe Leu Glu Ser Ile Asp Lys Tyr Arg Ala Ala Val Gln Asn 
            20                  25                  30          


Ile Tyr Thr Tyr Gly Cys Phe Asn Gln Lys Gln Leu Ser Glu Gln Cys 
        35                  40                  45              


Asn Cys Ser Asp Gln Thr Ile Lys Lys Ala Phe Asn Phe Tyr Asn Leu 
    50                  55                  60                  


Cys Leu Ala Asn Tyr Ile Lys Lys Lys Lys Gly Thr Leu Ser Lys Lys 
65                  70                  75                  80  


Ala Lys Gly Arg Pro Thr Glu Ala Lys Tyr Leu Glu Tyr Asp Arg Phe 
                85                  90                  95      


Thr Leu Asn Glu Asn Tyr Leu Tyr Asn Ile Tyr Leu Trp Ala Arg Ile 
            100                 105                 110         


Thr Lys Lys Gln Met Trp Ala Phe Ser Tyr Phe Arg Arg His Thr Ser 
        115                 120                 125             


Leu Leu Ile Asn Ala Ser Arg Thr Glu Ile Lys Asn Gln Leu Ser Asp 
    130                 135                 140                 


Phe Phe Leu Tyr Phe Ser Glu Tyr Met Asp Arg Ser Lys Lys Ala Glu 
145                 150                 155                 160 


Asn Ser Gln Asp Leu Gly Tyr Ile Ile Asp Met Thr Ala Pro Thr Glu 
                165                 170                 175     


Lys Asn Met Leu Ile Ser Ser Met Cys Asp Ala Leu Ala Val Phe Gly 
            180                 185                 190         


Arg Lys Ala Pro Tyr Ser Val Pro Ala Tyr Ser Ile Ser His Lys Leu 
        195                 200                 205             


Lys Lys Leu Cys Gly Asn Asp Ser Lys Ser Leu Trp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Asn Tyr Asp Arg Ile Leu Tyr Asp Glu Ala Val Tyr Thr Ile Arg 
225                 230                 235                 240 


Gln Ala Ile Arg Asp Arg Lys Leu Ile Gly Tyr Gln Thr Val Gly Thr 
                245                 250                 255     


Glu Lys Gln Lys Ser Val Asn Tyr Val Val Pro Leu Lys Ile Met Tyr 
            260                 265                 270         


Glu Tyr Asn Leu Gly Arg Cys Tyr Leu Leu Tyr Ser Pro Leu Asn Ser 
        275                 280                 285             


Asp Ser Ile Ile Lys Ser Ile Arg Leu Asp Lys Leu Tyr Lys Val Ala 
    290                 295                 300                 


Ala Tyr Glu Pro Asp Ser Ile Ile Asn Tyr Glu Lys Leu Tyr Asp Val 
305                 310                 315                 320 


Leu Ala Val Ala Glu Asn Glu Ile Trp Leu Ser Gly Asp Tyr Thr Lys 
                325                 330                 335     


Lys Asp Cys Leu Ser Arg Ile Val Leu Lys Asn Val Lys Pro Gln Ala 
            340                 345                 350         


Phe Ser Leu Ile Glu Lys Tyr Gly Val Cys Tyr Thr Glu Asp Arg Glu 
        355                 360                 365             


Ala Lys Thr Val Thr Phe Asn Ile Arg Lys Ala Asp Asp Ile Lys Pro 
    370                 375                 380                 


Phe Ile Arg Thr Leu Gly Gly Asp Ala Val Ile Ser Glu Glu Asp Asn 
385                 390                 395                 400 


Pro Gly Leu Phe Arg Glu Phe Ala Tyr Asp Ala Arg Ile Gly Arg Gln 
                405                 410                 415     


Met Tyr Tyr Asp Asp Ser Phe Ala Asp Cys Pro Ala Glu Lys Asp Ser 
            420                 425                 430         


Gln Pro Ala Lys Asp Ser Lys Thr Ala Ser Gly Asn Asp Asn Ile Lys 
        435                 440                 445             


Lys Tyr Ala Ser Tyr Pro Thr Leu Arg Leu Phe Asn Lys Tyr Gly Ser 
    450                 455                 460                 


Phe Met Asn Ile Leu Ala Glu Glu Leu Ala Glu His Ile Phe Ser Glu 
465                 470                 475                 480 


Ile Ile Arg Met Pro Val Glu Lys Arg Ala Gly Gln Ile Glu Tyr Ser 
                485                 490                 495     


Ser Asn Arg Leu Glu Arg Val Leu Asn Ser Tyr Phe Lys Ile Tyr Gly 
            500                 505                 510         


Phe Asp Glu Leu Arg Thr Glu Ala Ser Asn Ile Thr Glu Trp Phe Thr 
        515                 520                 525             


Lys Ala Thr Glu Glu Leu Ser Asp Ser Asp Tyr Ser Ser Trp Phe Ser 
    530                 535                 540                 


Val Asn Gly Gly Lys Phe Glu Ala Val Ala Asp Leu Asn Glu Tyr Glu 
545                 550                 555                 560 


His Lys Gln Leu Leu Thr Asn Ile Glu Tyr Glu Tyr Leu Arg Leu Met 
                565                 570                 575     


Leu Gly Asp Pro Asp Ala Arg Ala Ile Ile Gly Asn Glu Tyr Cys Glu 
            580                 585                 590         


Lys Leu Ser Glu Tyr Val Gly Ser Ala Asp Thr Thr Leu Asp Glu Phe 
        595                 600                 605             


Phe Thr Val Arg Tyr Ala Asn Arg Asn Glu Lys Thr Ile Glu Asn Lys 
    610                 615                 620                 


His Ser Val Leu Arg Thr Ile Met Arg Ala Met Asn Asn Glu Lys Lys 
625                 630                 635                 640 


Ala Asp Ile Glu Tyr Lys Gly Lys His Tyr Ile Cys Ser Ala Tyr Arg 
                645                 650                 655     


Phe Thr Tyr Ser Leu Arg Glu Arg Lys His Arg Leu Met Val Phe Asp 
            660                 665                 670         


Gly Asn Tyr Ile Met Gln Ile Asn Leu Cys Asp Ile Lys Asp Ala Gln 
        675                 680                 685             


Met Thr Lys Glu Pro Ser Leu Ser Asp Glu Glu Met Asn Lys Leu Leu 
    690                 695                 700                 


Thr Glu Arg Lys Lys Tyr Ile Glu Ile Ala Ile Pro Gln Asn Ala Asp 
705                 710                 715                 720 


Ala Gln Gln Arg Asn Val Phe Glu Arg Ala Leu Arg Leu Phe Gly Gly 
                725                 730                 735     


Phe Glu Arg Tyr Ser Trp Asn Asp Ala Lys Asn Gly Glu Tyr Val Ile 
            740                 745                 750         


Ala Val Ala Tyr Tyr Glu Pro Asp Ile Ser Val Ser Ser Ser Ala Asp 
        755                 760                 765             


Arg Arg Ile Tyr Arg Arg Asp Thr Val Ala Ala Asp Ile Met Ser Leu 
    770                 775                 780                 


Gly Arg Tyr Ala Arg Val Met Lys Gln Pro Gly Phe Glu Leu Asp Gly 
785                 790                 795                 800 


Val Arg Tyr Asp Ser Ser Leu Tyr Asp Tyr Ile Ser Lys Asn Tyr Ser 
                805                 810                 815     


Gly Thr Ala Ala Arg Tyr Glu Lys Pro Lys Lys Lys Arg Lys Val 
            820                 825                 830     


<210>  314
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  WYL Ruminococcus sp.isolate 2789STDY5834971 + C-term  NLS

<400>  314

Met Leu Ile Leu Pro Ser Thr Phe Leu Pro Lys Arg Asp Lys Asn Val 
1               5                   10                  15      


Pro Tyr Ile Ala Glu Val Gln Ser Ile Pro Leu Ser Pro Ser Ala Tyr 
            20                  25                  30          


Ser Val Ile Ile Lys Asp Lys Ser Ile Phe Glu Thr Ser Leu Ser Pro 
        35                  40                  45              


Asn Gly Ser Val Ser Met Ser Ser Phe Leu Thr Ser Ile Phe Asp Ser 
    50                  55                  60                  


Ala Tyr Ile Ala Ser Leu Lys Tyr Lys Ser Glu Lys Tyr Asn Gly Ile 
65                  70                  75                  80  


Pro Leu Leu Asn Ala Phe Val Lys Trp Gln Ile Glu Glu Ile Asn Asp 
                85                  90                  95      


Gly Leu Asp Asp Lys Ser Lys Glu Ile Ile Lys Ser Tyr Leu Ile Ser 
            100                 105                 110         


Lys Leu Ser Ala Lys Tyr Glu Lys Thr Lys Thr Glu Asn Ala Val Arg 
        115                 120                 125             


Val Arg Leu Ser Ile Cys Arg Asp Leu Tyr Asp Thr Leu Ser Ser Asp 
    130                 135                 140                 


Asp Leu Tyr Tyr Glu Asn Lys Val Tyr Ser Ser Thr Leu Arg Arg Phe 
145                 150                 155                 160 


Leu Lys Ala Val Tyr Glu Asp Tyr Ala Leu Leu Ser Asp Cys Glu Arg 
                165                 170                 175     


Glu Arg Leu Ile Phe Ala Asp Asn Ile Ile Lys Ile Asn Glu Val Ile 
            180                 185                 190         


Lys Gln Asn Gly Ser Arg Tyr Tyr Ser Phe Ile Tyr Ala Tyr Ser Asn 
        195                 200                 205             


Met Tyr Ser Arg Glu Lys Arg Arg Ile Arg Leu Ile Pro Tyr Arg Ile 
    210                 215                 220                 


Val Ser Asp Glu Tyr Lys Met Tyr Asn Tyr Leu Val Cys Leu Ser Asp 
225                 230                 235                 240 


Glu Lys Ser Ala Gly Lys Glu Phe Lys Ala Asp Ser Tyr Arg Ile Ser 
                245                 250                 255     


Arg Leu Ser Gly Leu Ser Ile Ala Glu Lys Leu Ser Gln Lys Glu Tyr 
            260                 265                 270         


Ser Ser Val Thr Glu Tyr Glu Arg Leu Lys Glu Gly His Val Lys Ser 
        275                 280                 285             


Val Lys His Leu Leu Ser Asp Pro Arg Phe Gly Ser Asp Glu Ser Asp 
    290                 295                 300                 


Ile Ser Lys Val Tyr Leu Thr Glu Lys Gly Val Glu Met Phe Gly Lys 
305                 310                 315                 320 


Ile Leu Tyr Gln Arg Pro Ile Leu Lys Gly Asn Glu Lys Pro Lys Pro 
                325                 330                 335     


Asn Ala Val Asn Glu Phe Ile Ser Pro Pro Ile Gln Val Lys Tyr Tyr 
            340                 345                 350         


Phe Asn Lys Phe Gly Lys Asp Gly Val Ile Leu Ser Pro Ser Asp Ser 
        355                 360                 365             


Phe Glu Glu Met Arg Thr Leu Tyr Val Glu Gly Ala Glu Ala Tyr Asn 
    370                 375                 380                 


Arg Glu Val Glu Met Pro Lys Lys Lys Arg Lys Val 
385                 390                 395     


<210>  315
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  WYL Ruminococcus bicirculans + C-term NLS

<400>  315

Met Ser Met Thr Pro Ser Thr Phe Leu Pro Lys Arg Glu Asp Gly Val 
1               5                   10                  15      


Pro Tyr Ile Ala Glu Val Gln Ser Ile Pro Leu Ser Pro Ser Ala Tyr 
            20                  25                  30          


Ser Val Ile Ile Lys Asp Lys Ser Ile Phe Glu Thr Ser Leu Ser Pro 
        35                  40                  45              


Asn Gly Ser Val Ser Met Ser Ser Phe Leu Thr Ser Ile Phe Asp Ser 
    50                  55                  60                  


Ala Tyr Ile Ala Ser Leu Lys Tyr Lys Ser Asp Asp Asn Tyr Lys Tyr 
65                  70                  75                  80  


Ile Gly Ile Pro Leu Leu Asn Ala Phe Val Lys Trp Gln Ile Glu Glu 
                85                  90                  95      


Ile Asp Asp Ser Leu Asp Asp Lys Ser Lys Glu Ile Ile Lys Ser Tyr 
            100                 105                 110         


Leu Ile Ser Lys Leu Ser Ala Lys Tyr Glu Lys Thr Lys Thr Glu Asn 
        115                 120                 125             


Ala Val Arg Val Arg Leu Ser Ile Cys Arg Asp Leu Tyr Asp Thr Leu 
    130                 135                 140                 


Ser Ser Asp Asp Leu Tyr Tyr Glu Asn Lys Val Tyr Ser Ser Thr Leu 
145                 150                 155                 160 


Arg Arg Phe Leu Lys Ala Val Tyr Glu Asp Tyr Ala Leu Leu Ser Asp 
                165                 170                 175     


Cys Glu Arg Glu Arg Leu Ile Phe Ala Asp Asn Ile Ile Lys Ile Asn 
            180                 185                 190         


Glu Val Ile Lys Gln Asn Gly Ser Arg Tyr Tyr Ser Phe Ile Tyr Ala 
        195                 200                 205             


Tyr Ser Asn Met Tyr Ser Arg Glu Lys Arg Arg Ile Arg Leu Ile Pro 
    210                 215                 220                 


Tyr Arg Ile Val Ser Asp Glu Tyr Lys Met Tyr Asn Tyr Leu Val Cys 
225                 230                 235                 240 


Leu Ser Asp Glu Lys Ser Ala Gly Lys Glu Phe Lys Ala Asp Ser Tyr 
                245                 250                 255     


Arg Ile Ser Arg Leu Ser Gly Leu Ser Ile Ala Glu Lys Leu Ser Gln 
            260                 265                 270         


Lys Glu Tyr Ser Ser Val Thr Glu Tyr Glu Arg Leu Lys Glu Gly His 
        275                 280                 285             


Val Lys Ser Val Lys His Leu Leu Ser Asp Pro Arg Phe Gly Ser Asp 
    290                 295                 300                 


Glu Ser Asp Ile Ser Lys Val Tyr Leu Thr Glu Lys Gly Val Glu Met 
305                 310                 315                 320 


Phe Gly Lys Ile Leu Tyr Gln Arg Pro Ile Leu Lys Gly Asn Glu Lys 
                325                 330                 335     


Pro Lys Pro Asn Ala Val Asn Glu Phe Ile Ser Pro Pro Ile Gln Val 
            340                 345                 350         


Lys Tyr Tyr Phe Asn Lys Phe Gly Lys Asp Gly Val Ile Leu Ser Pro 
        355                 360                 365             


Ser Asp Ser Phe Glu Glu Met Arg Thr Leu Tyr Val Glu Gly Ala Glu 
    370                 375                 380                 


Ala Tyr Asn Arg Glu Val Glu Met Pro Lys Lys Lys Arg Lys Val 
385                 390                 395                 


<210>  316
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  WYL Ruminococcus sp. isolate 2789STDY5608892 + C-term NLS

<400>  316

Met Leu Ile Pro Pro Ser Thr Phe Leu Pro Lys Arg Asp Lys Asn Val 
1               5                   10                  15      


Pro Tyr Ile Ala Glu Val Gln Ser Ile Pro Leu Ser Pro Ser Ala Tyr 
            20                  25                  30          


Ser Val Ile Ile Lys Asp Lys Ser Ile Phe Glu Thr Ser Leu Ser Pro 
        35                  40                  45              


Asn Gly Ser Val Ser Met Ser Ser Phe Leu Thr Ser Ile Phe Asp Ser 
    50                  55                  60                  


Ala Tyr Ile Ala Ser Leu Lys Tyr Lys Ser Asp Asp Asn Tyr Lys Tyr 
65                  70                  75                  80  


Ile Gly Ile Pro Leu Leu Asn Ala Phe Val Glu Trp Gln Ile Glu Glu 
                85                  90                  95      


Ile Asp Asp Ser Leu Asp Asp Lys Ser Lys Glu Ile Ile Lys Ser Tyr 
            100                 105                 110         


Leu Ile Ser Lys Leu Ser Ala Lys Tyr Glu Lys Thr Lys Thr Glu Asn 
        115                 120                 125             


Ala Val Arg Val Arg Leu Ser Ile Cys Arg Asp Leu Tyr Asp Thr Leu 
    130                 135                 140                 


Ser Ser Asp Asp Leu Tyr Tyr Glu Asn Lys Val Tyr Ser Leu Thr Leu 
145                 150                 155                 160 


Arg Arg Phe Leu Lys Ala Val Tyr Glu Asp Tyr Ala Leu Leu Ser Asp 
                165                 170                 175     


Cys Glu Arg Glu Arg Leu Ile Phe Ala Asp Asn Ile Ile Lys Ile Asn 
            180                 185                 190         


Glu Val Ile Lys Gln Asn Gly Ser Arg Tyr Tyr Ser Phe Ile Tyr Ala 
        195                 200                 205             


Tyr Ser Asn Met Tyr Ser Arg Glu Lys Arg Arg Ile Arg Leu Ile Pro 
    210                 215                 220                 


Tyr Arg Ile Val Ser Asp Glu Tyr Lys Met Tyr Asn Tyr Leu Val Cys 
225                 230                 235                 240 


Leu Ser Asp Glu Lys Ser Ala Gly Lys Glu Phe Lys Ala Asp Ser Tyr 
                245                 250                 255     


Arg Ile Ser Arg Leu Ser Gly Leu Ser Ile Ala Glu Lys Leu Ser Gln 
            260                 265                 270         


Lys Glu Tyr Ser Ser Val Thr Glu Tyr Glu Arg Leu Lys Glu Gly His 
        275                 280                 285             


Val Lys Ser Val Lys His Leu Leu Ser Asp Pro Arg Phe Gly Ser Asp 
    290                 295                 300                 


Glu Ser Asp Ile Ser Lys Val Tyr Leu Thr Glu Lys Gly Val Glu Met 
305                 310                 315                 320 


Phe Gly Lys Ile Leu Tyr Gln Arg Pro Ile Leu Lys Gly Asn Glu Lys 
                325                 330                 335     


Pro Lys Pro Asn Thr Val Asn Glu Phe Ile Ser Pro Pro Ile Gln Val 
            340                 345                 350         


Lys Tyr Tyr Phe Asn Lys Phe Gly Lys Asp Gly Val Ile Leu Ser Pro 
        355                 360                 365             


Ser Asp Ser Phe Glu Glu Met Arg Thr Leu Tyr Val Glu Gly Ala Glu 
    370                 375                 380                 


Ala Tyr Asn Arg Glu Val Glu Met Pro Lys Lys Lys Arg Lys Val 
385                 390                 395                 


<210>  317
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  WYL Ruminococcus sp. CAG:57 + C-term NLS

<400>  317

Met Leu Ile Pro Pro Ser Thr Phe Leu Pro Lys Arg Asp Lys Asn Val 
1               5                   10                  15      


Pro Tyr Ile Ala Glu Val Gln Ser Ile Pro Leu Ser Pro Ser Ala Tyr 
            20                  25                  30          


Ser Val Ile Ile Lys Asp Lys Ser Ile Phe Glu Thr Ser Leu Ser Pro 
        35                  40                  45              


Asn Gly Ser Val Ser Met Ser Ser Phe Leu Thr Ser Ile Phe Asp Ser 
    50                  55                  60                  


Ala Tyr Ile Ala Ser Leu Lys Tyr Lys Ser Asp Asp Asn Tyr Lys Tyr 
65                  70                  75                  80  


Ile Gly Ile Pro Leu Leu Asn Ala Phe Val Glu Trp Gln Ile Glu Glu 
                85                  90                  95      


Ile Asp Asp Ser Leu Asp Asp Lys Ser Lys Glu Ile Ile Lys Ser Tyr 
            100                 105                 110         


Leu Ile Ser Lys Leu Ser Ala Lys Tyr Glu Lys Thr Lys Thr Glu Asn 
        115                 120                 125             


Ala Val Arg Val Arg Leu Ser Ile Cys Arg Asp Leu Tyr Asp Thr Leu 
    130                 135                 140                 


Ser Ser Asp Asp Leu Tyr Tyr Glu Asn Lys Val Tyr Ser Leu Thr Leu 
145                 150                 155                 160 


Arg Arg Phe Leu Lys Ala Val Tyr Glu Asp Tyr Ala Leu Leu Ser Asp 
                165                 170                 175     


Cys Glu Arg Glu Arg Leu Ile Phe Ala Asp Asn Ile Ile Lys Ile Asn 
            180                 185                 190         


Glu Val Ile Lys Gln Asn Gly Ser Arg Tyr Tyr Ser Phe Ile Tyr Ala 
        195                 200                 205             


Tyr Ser Asn Met Tyr Ser Arg Glu Lys Arg Arg Ile Arg Leu Ile Pro 
    210                 215                 220                 


Tyr Arg Ile Val Ser Asp Glu Tyr Lys Met Tyr Asn Tyr Leu Val Cys 
225                 230                 235                 240 


Leu Ser Asp Glu Lys Ser Ala Gly Lys Glu Phe Lys Ala Asp Ser Tyr 
                245                 250                 255     


Arg Ile Ser Arg Leu Ser Gly Leu Ser Ile Ala Glu Lys Leu Ser Gln 
            260                 265                 270         


Lys Glu Tyr Ser Ser Val Thr Glu Tyr Glu Arg Leu Lys Glu Gly His 
        275                 280                 285             


Val Lys Ser Val Lys His Leu Leu Ser Asp Pro Arg Phe Gly Ser Asp 
    290                 295                 300                 


Glu Ser Asp Ile Ser Lys Val Tyr Leu Thr Glu Lys Gly Val Glu Met 
305                 310                 315                 320 


Phe Gly Lys Ile Leu Tyr Gln Arg Pro Ile Leu Lys Gly Asn Glu Lys 
                325                 330                 335     


Pro Lys Pro Asn Thr Val Asn Glu Phe Ile Ser Pro Pro Ile Gln Val 
            340                 345                 350         


Lys Tyr Tyr Phe Asn Lys Phe Gly Lys Asp Gly Val Ile Leu Ser Pro 
        355                 360                 365             


Ser Asp Ser Phe Glu Glu Met Arg Thr Leu Tyr Val Glu Gly Ala Glu 
    370                 375                 380                 


Ala Tyr Asn Arg Glu Val Glu Met Pro Lys Lys Lys Arg Lys Val 
385                 390                 395                 


<210>  318
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  WYL Ruminococcus flavefaciens FD-1 + C-term NLS

<400>  318

Met Ile Ile Ala Ile Asn Gln Trp Lys Arg Arg Phe Ser Leu Val Ile 
1               5                   10                  15      


Tyr Gly Lys Ser Glu Gly Glu Thr Ile Val Lys Ile Lys Leu Leu Leu 
            20                  25                  30          


Ile Ser Leu Ala Tyr Leu Ile Ser Ile Tyr Leu Leu Cys Ser Pro Gly 
        35                  40                  45              


Cys Ile Gly Ile Phe Thr His Gly Met Leu Thr Thr Val Ile Gly Val 
    50                  55                  60                  


Val Thr Met Leu Ala Ala Thr Gly Thr Tyr Gly Met Tyr Leu Tyr Ser 
65                  70                  75                  80  


Ser Ala Ile Gly Glu Arg Ser Leu Pro Glu Ile Pro Met Asn Lys Glu 
                85                  90                  95      


Thr Glu Tyr Ser Arg Tyr Lys Glu Leu Glu Asn Trp Phe Arg Ala Phe 
            100                 105                 110         


Arg Tyr Leu Asp Arg Asn Asn Asn Phe Ala Met Leu Ser Ser Asp Leu 
        115                 120                 125             


Ala Thr Ser Tyr His Asp Gly Leu Ile Arg Asp Asn Pro Phe Arg Asn 
    130                 135                 140                 


Thr Glu Leu Gly Asp Arg Leu Gln Thr Thr Ser Ser Asp Ile Ser Ile 
145                 150                 155                 160 


Lys Tyr Asp Gln Thr Leu Lys Ile Leu Ser Glu Ser Phe Glu Lys Asn 
                165                 170                 175     


Asp Ile Thr Tyr Gln Asn Tyr Leu Ser Val Leu Asp Asn Val Leu Lys 
            180                 185                 190         


Leu Ser Ser Ser His Leu Lys Ala Ile Lys Lys Arg Val Cys Val Phe 
        195                 200                 205             


Asp Tyr Arg Thr Trp Ala Asp Asn Lys Asn Asp Glu Met Cys Arg Lys 
    210                 215                 220                 


Tyr Ile Glu Glu Val Lys Ser Ser Val Ile Arg Leu Glu Glu Ile Glu 
225                 230                 235                 240 


Gly Lys Phe Asp Asn Leu Leu His Glu Leu Ile Cys Leu Ser Glu Ile 
                245                 250                 255     


Ser Glu Asp Pro Leu Leu Glu Met Gln Asp Leu Ile Glu Thr Thr Ser 
            260                 265                 270         


Asp Tyr Lys Ser Ile Glu Asp Gln Pro Lys Lys Lys Arg Lys Val 
        275                 280                 285         


<210>  319
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  WYL Ruminococcus albus strain KH2T6 + C-term NLS

<400>  319

Met Cys Thr Trp Tyr Tyr Ala Glu Ala Lys Ser Leu Ser Phe Phe Ile 
1               5                   10                  15      


Asp Lys Ala Ser Gln Leu Pro Leu Ser Asp Ile Ile Met Asn Thr Met 
            20                  25                  30          


Ser Lys Ser Lys Ala Met Ser Gly Asn Ile Arg Pro Thr Asp Met Ala 
        35                  40                  45              


Ala Val Leu Ala Pro Asn Lys Gln Gly Asn Val Ala Val Phe Pro Met 
    50                  55                  60                  


Ile Trp Gly Phe Thr His Glu Ser Thr Ser Lys Pro Val Ile Asn Cys 
65                  70                  75                  80  


Arg Ile Glu Ser Ala Asp Thr Lys Pro Leu Trp Lys Asp Ser Trp Tyr 
                85                  90                  95      


Arg Arg Arg Cys Val Ile Pro Ala Ser Trp Tyr Tyr Glu Trp Gly Val 
            100                 105                 110         


Pro Pro Ser Glu Gly Glu Leu Tyr His Lys Asn Glu Tyr Asn Lys Ile 
        115                 120                 125             


Gln Lys Glu Lys Tyr Ala Ile Gln Pro Glu Gly Ala Glu Ile Thr Tyr 
    130                 135                 140                 


Leu Ala Gly Leu Tyr Arg Phe Glu Glu His Arg Gly Val Gln Val Pro 
145                 150                 155                 160 


Met Phe Ala Val Ile Thr Arg Glu Ser Val Glu Pro Val Ser Ser Ile 
                165                 170                 175     


His Asp Arg Met Pro Leu Ile Leu Gly Lys Asp Ser Leu Ser Glu Trp 
            180                 185                 190         


Ile His Pro Asn Gly Asp Pro Asn Lys Ile Ala Lys Thr Ala Leu Thr 
        195                 200                 205             


Lys Met Val Met Glu Lys Ala Ile Asp Tyr Pro Glu Pro Glu Pro Ser 
    210                 215                 220                 


Phe Met Pro Lys Lys Lys Arg Lys Val 
225                 230             


<210>  320
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  WYL Ruminococcus flavefaciens strain XPD3002 + C-term NLS

<400>  320

Met Glu Leu Phe Asn Glu Tyr Arg Asn Lys Ser Leu Arg Ala Phe Leu 
1               5                   10                  15      


Lys Leu Ala Glu Arg Ile Ser Tyr Gly Glu Glu Leu Ser Ile Asp Glu 
            20                  25                  30          


Phe Glu Ala Glu Tyr Tyr Arg Leu Ser Gly Asp Asn Lys Lys Ile Thr 
        35                  40                  45              


Ser Val Phe Tyr Lys Asn Thr Leu Tyr Asn Asp Lys Leu Pro Ile Phe 
    50                  55                  60                  


Asp Thr Arg Glu Gly Lys Val Arg Leu Phe Gly Glu Pro Asp Lys Cys 
65                  70                  75                  80  


Ser Asn Lys His Ile Ser Asp Thr Leu Leu Lys Ser Glu Ile Thr Trp 
                85                  90                  95      


Leu His Asn Ala Leu Asn Asp Lys Leu Ser Lys Leu Phe Leu Ser Asp 
            100                 105                 110         


Glu Glu Arg Ile Ser Ile Asp Ala Lys Leu Ser Asp Tyr Thr Glu Tyr 
        115                 120                 125             


Tyr Lys Asn Ile Asp Asp Met Trp Arg Ser Asn Glu Asp Ile Ser Glu 
    130                 135                 140                 


Glu Val Glu Lys Asn Phe Lys Ile Ile Leu Lys Ala Ile Asn Glu Lys 
145                 150                 155                 160 


Gln Ala Leu Ser Tyr Thr Phe Lys Asn Lys Asn Cys Glu Gly Phe Pro 
                165                 170                 175     


Val Arg Ile Glu Tyr Asp Glu Arg Thr Cys Arg Ile Tyr Met Ile Ile 
            180                 185                 190         


Tyr Asp Gly Asn Arg Phe Val Lys Ser Asp Ile Ser Lys Leu Ser Asp 
        195                 200                 205             


Ile Tyr Ile Thr Glu Asn Ser Ile Asp Thr Ile Pro Glu Ile Lys Asp 
    210                 215                 220                 


Asp Met Leu Asn Lys Lys Ala Tyr Leu Pro Val Val Phe Thr Val Thr 
225                 230                 235                 240 


Asp Asp Lys Asn Arg Lys Ala Ile Asp Arg Ala Leu Leu Ala Phe Ser 
                245                 250                 255     


Val Tyr Asp His Val Val Glu Pro Ile Asp Glu Lys Thr Ala Arg Phe 
            260                 265                 270         


Thr Ile Gln Tyr Tyr Thr Met Asp Leu Asp Leu Leu Ile Lys Asp Ile 
        275                 280                 285             


Leu Ala Phe Gly Ser Asp Ile Lys Val Glu Ser Pro Arg Tyr Val Val 
    290                 295                 300                 


Lys Arg Ile Thr Asp Ile Leu Arg Lys Val Pro Lys Lys Lys Arg Lys 
305                 310                 315                 320 


Val 
    


<210>  321
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RtcB Eubacterium siraeum + C-term NLS

<400>  321

Met Ile Val Leu Glu Ile Ile Gly Glu Arg Asn Thr Ala Val Val Tyr 
1               5                   10                  15      


Gly Glu Ile Ile Asp Glu Cys Ala Val Ser Gln Ile Glu Glu Ile Cys 
            20                  25                  30          


Asn His Pro Ala Phe Glu Asn Ser Arg Ile Arg Ile Met Pro Asp Cys 
        35                  40                  45              


His Ala Gly Lys Gly Cys Val Ile Gly Phe Thr Cys Val Thr Ser Asn 
    50                  55                  60                  


Arg Met Ile Val Pro Asn Ile Val Gly Val Asp Ile Gly Cys Gly Ile 
65                  70                  75                  80  


Leu Thr Thr Val Phe Thr Ala Asp Arg Glu Ile Asp Tyr Arg Ala Leu 
                85                  90                  95      


Asp Thr Phe Ile Arg Ser Asn Ile Pro Ser Gly Met Glu Ile His Asp 
            100                 105                 110         


Ser Val Ser Asp Thr Val Ala Glu Asn Thr Ala Leu Ile Ala Lys Val 
        115                 120                 125             


Asn Gly Ile Cys Asp Ala Ile Gly Glu Ser Ala Asp Val Asp Tyr His 
    130                 135                 140                 


Leu Arg Ser Ile Gly Thr Leu Gly Gly Gly Asn His Phe Ile Glu Ile 
145                 150                 155                 160 


Asp Arg Leu Asn Asn Gly Asn Tyr Ala Leu Thr Val His Thr Gly Ser 
                165                 170                 175     


Arg Asn Leu Gly Lys Arg Ile Cys Gly Tyr Phe Gln Ser Asn Ala Ser 
            180                 185                 190         


Val Ile Asp Thr Glu Leu Arg Arg Ser Ile Leu Leu Arg His Arg Ser 
        195                 200                 205             


Ala Thr Thr Ser Glu Glu His Glu Glu Ile Asp Arg Arg Ala Ala Gln 
    210                 215                 220                 


Ile Ala Pro Val Ser Lys Glu Leu Ala Phe Ile Thr Gly Glu Arg Tyr 
225                 230                 235                 240 


Asp Ser Tyr Ile Gly Cys Met Leu Asp Ala Lys Ala Leu Ala Ala Phe 
                245                 250                 255     


Asn Arg Thr Val Ile Ser Asp Arg Ile Met Ser Phe Leu Ala Asp Glu 
            260                 265                 270         


Tyr Gly Val Glu Ile Lys Asp Arg Phe Asp Thr Val His Asn Tyr Ile 
        275                 280                 285             


Asp Trp Tyr Asp Asp Thr His Thr Ser Val Val Ile Arg Lys Gly Ala 
    290                 295                 300                 


Ile Ser Ala Arg Lys Gly Glu Arg Ile Val Ile Pro Leu Asn Met Arg 
305                 310                 315                 320 


Asp Gly Ile Ile Ile Ala His Gly Arg Gly Asn Glu Glu Trp Asn Cys 
                325                 330                 335     


Ser Ala Pro His Gly Ser Gly Arg Ala Tyr Ser Arg Ser Asp Ala Arg 
            340                 345                 350         


Arg Thr Phe Thr Leu Glu Glu Tyr Val Glu Glu Met Asp Gly Val Asn 
        355                 360                 365             


Thr Trp Ser Val Ser Glu Ser Thr Ile Asp Glu Cys Pro Met Ala Tyr 
    370                 375                 380                 


Lys Pro Ser Glu Met Ile Ile Gly Ser Ile Gly Asp Thr Val Glu Ile 
385                 390                 395                 400 


Glu Ser Ile Ala His Thr Val Tyr Asn Phe Lys Ala Pro Lys Lys Lys 
                405                 410                 415     


Arg Lys Val 
            


<210>  322
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasRx Direct Repeat

<400>  322
tacccctacc aactggtcgg ggtttgaaac                                        30


<210>  323

<400>  323
000

<210>  324

<400>  324
000

<210>  325
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNAse1

<400>  325

Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Leu Cys Lys Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


<210>  326
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNAse4

<400>  326

Gln Asp Gly Met Tyr Gln Arg Phe Leu Arg Gln His Val His Pro Glu 
1               5                   10                  15      


Glu Thr Gly Gly Ser Asp Arg Tyr Cys Asp Leu Met Met Gln Arg Arg 
            20                  25                  30          


Lys Met Thr Leu Tyr His Cys Lys Arg Phe Asn Thr Phe Ile His Glu 
        35                  40                  45              


Asp Ile Trp Asn Ile Arg Ser Ile Cys Ser Thr Thr Asn Ile Gln Cys 
    50                  55                  60                  


Lys Asn Gly Lys Met Asn Cys His Glu Gly Val Val Lys Val Thr Asp 
65                  70                  75                  80  


Cys Arg Asp Thr Gly Ser Ser Arg Ala Pro Asn Cys Arg Tyr Arg Ala 
                85                  90                  95      


Ile Ala Ser Thr Arg Arg Val Val Ile Ala Cys Glu Gly Asn Pro Gln 
            100                 105                 110         


Val Pro Val His Phe Asp Gly 
        115                 


<210>  327
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNAse6

<400>  327

Trp Pro Lys Arg Leu Thr Lys Ala His Trp Phe Glu Ile Gln His Ile 
1               5                   10                  15      


Gln Pro Ser Pro Leu Gln Cys Asn Arg Ala Met Ser Gly Ile Asn Asn 
            20                  25                  30          


Tyr Thr Gln His Cys Lys His Gln Asn Thr Phe Leu His Asp Ser Phe 
        35                  40                  45              


Gln Asn Val Ala Ala Val Cys Asp Leu Leu Ser Ile Val Cys Lys Asn 
    50                  55                  60                  


Arg Arg His Asn Cys His Gln Ser Ser Lys Pro Val Asn Met Thr Asp 
65                  70                  75                  80  


Cys Arg Leu Thr Ser Gly Lys Tyr Pro Gln Cys Arg Tyr Ser Ala Ala 
                85                  90                  95      


Ala Gln Tyr Lys Phe Phe Ile Val Ala Cys Asp Pro Pro Gln Lys Ser 
            100                 105                 110         


Asp Pro Pro Tyr Lys Leu Val Pro Val His Leu Asp Ser Ile Leu 
        115                 120                 125         


<210>  328
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNAse7

<400>  328

Ala Pro Ala Arg Ala Gly Phe Cys Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Trp Val Ala Glu Ile Pro Val Ser Ala Lys Pro Lys Gly Met 
            20                  25                  30          


Thr Ser Ser Gln Trp Phe Lys Ile Gln His Met Gln Pro Ser Pro Gln 
        35                  40                  45              


Ala Cys Asn Ser Ala Met Lys Asn Ile Asn Lys His Thr Lys Arg Cys 
    50                  55                  60                  


Lys Asp Leu Asn Thr Phe Leu His Glu Pro Phe Ser Ser Val Ala Ala 
65                  70                  75                  80  


Thr Cys Gln Thr Pro Lys Ile Ala Cys Lys Asn Gly Asp Lys Asn Cys 
                85                  90                  95      


His Gln Ser His Gly Pro Val Ser Leu Thr Met Cys Lys Leu Thr Ser 
            100                 105                 110         


Gly Lys Tyr Pro Asn Cys Arg Tyr Lys Glu Lys Arg Gln Asn Lys Ser 
        115                 120                 125             


Tyr Val Val Ala Cys Lys Pro Pro Gln Lys Lys Asp Ser Gln Gln Phe 
    130                 135                 140                 


His Leu Val Pro Val His Leu Asp Arg Val Leu 
145                 150                 155 


<210>  329
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNAse8

<400>  329

Thr Ser Ser Gln Trp Phe Lys Thr Gln His Val Gln Pro Ser Pro Gln 
1               5                   10                  15      


Ala Cys Asn Ser Ala Met Ser Ile Ile Asn Lys Tyr Thr Glu Arg Cys 
            20                  25                  30          


Lys Asp Leu Asn Thr Phe Leu His Glu Pro Phe Ser Ser Val Ala Ile 
        35                  40                  45              


Thr Cys Gln Thr Pro Asn Ile Ala Cys Lys Asn Ser Cys Lys Asn Cys 
    50                  55                  60                  


His Gln Ser His Gly Pro Met Ser Leu Thr Met Gly Glu Leu Thr Ser 
65                  70                  75                  80  


Gly Lys Tyr Pro Asn Cys Arg Tyr Lys Glu Lys His Leu Asn Thr Pro 
                85                  90                  95      


Tyr Ile Val Ala Cys Asp Pro Pro Gln Gln Gly Asp Pro Gly Tyr Pro 
            100                 105                 110         


Leu Val Pro Val His Leu Asp Lys Val Val 
        115                 120         


<210>  330
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNAse2

<400>  330

Lys Pro Pro Gln Phe Thr Trp Ala Gln Trp Phe Glu Thr Gln His Ile 
1               5                   10                  15      


Asn Met Thr Ser Gln Gln Cys Thr Asn Ala Met Gln Val Ile Asn Asn 
            20                  25                  30          


Tyr Gln Arg Arg Cys Lys Asn Gln Asn Thr Phe Leu Leu Thr Thr Phe 
        35                  40                  45              


Ala Asn Val Val Asn Val Cys Gly Asn Pro Asn Met Thr Cys Pro Ser 
    50                  55                  60                  


Asn Lys Thr Arg Lys Asn Cys His His Ser Gly Ser Gln Val Pro Leu 
65                  70                  75                  80  


Ile His Cys Asn Leu Thr Thr Pro Ser Pro Gln Asn Ile Ser Asn Cys 
                85                  90                  95      


Arg Tyr Ala Gln Thr Pro Ala Asn Met Phe Tyr Ile Val Ala Cys Asp 
            100                 105                 110         


Asn Arg Asp Gln Arg Arg Asp Pro Pro Gln Tyr Pro Val Val Pro Val 
        115                 120                 125             


His Leu Asp Arg Ile Ile 
    130                 


<210>  331
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNAse6PL

<400>  331

Asp Lys Arg Leu Arg Asp Asn His Glu Trp Lys Lys Leu Ile Met Val 
1               5                   10                  15      


Gln His Trp Pro Glu Thr Val Cys Glu Lys Ile Gln Asn Asp Cys Arg 
            20                  25                  30          


Asp Pro Pro Asp Tyr Trp Thr Ile His Gly Leu Trp Pro Asp Lys Ser 
        35                  40                  45              


Glu Gly Cys Asn Arg Ser Trp Pro Phe Asn Leu Glu Glu Ile Lys Lys 
    50                  55                  60                  


Asn Trp Met Glu Ile Thr Asp Ser Ser Leu Pro Ser Pro Ser Met Gly 
65                  70                  75                  80  


Pro Ala Pro Pro Arg Trp Met Arg Ser Thr Pro Arg Arg Ser Thr Leu 
                85                  90                  95      


Ala Glu Ala Trp Asn Ser Thr Gly Ser Trp Thr Ser Thr Gly Gly Cys 
            100                 105                 110         


Ala Leu Pro Pro Ala Ala Leu Pro Ser Gly Asp Leu Cys Cys Arg Pro 
        115                 120                 125             


Ser Leu Thr Ala Gly Ser Arg Gly Val Gly Val Asp Leu Thr Ala Leu 
    130                 135                 140                 


His Gln Leu Leu His Val His Tyr Ser Ala Thr Gly Ile Ile Pro Glu 
145                 150                 155                 160 


Glu Cys Ser Glu Pro Thr Lys Pro Phe Gln Ile Ile Leu His His Asp 
                165                 170                 175     


His Thr Glu Trp Val Gln Ser Ile Gly Met Pro Ile Trp Gly Thr Ile 
            180                 185                 190         


Ser Ser Ser Glu Ser Ala Ile Gly Lys Asn Glu Glu Ser Gln Pro Ala 
        195                 200                 205             


Cys Ala Val Leu Ser His Asp Ser 
    210                 215     


<210>  332
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNAseL

<400>  332

Ala Ala Val Glu Asp Asn His Leu Leu Ile Lys Ala Val Gln Asn Glu 
1               5                   10                  15      


Asp Val Asp Leu Val Gln Gln Leu Leu Glu Gly Gly Ala Asn Val Asn 
            20                  25                  30          


Phe Gln Glu Glu Glu Gly Gly Trp Thr Pro Leu His Asn Ala Val Gln 
        35                  40                  45              


Met Ser Arg Glu Asp Ile Val Glu Leu Leu Leu Arg His Gly Ala Asp 
    50                  55                  60                  


Pro Val Leu Arg Lys Lys Asn Gly Ala Thr Pro Phe Ile Leu Ala Ala 
65                  70                  75                  80  


Ile Ala Gly Ser Val Lys Asp Leu Leu Lys Leu Phe Leu Ser Lys Gly 
                85                  90                  95      


Ala Asp Val Asn Glu Cys Asp Phe Tyr Gly Phe Thr Ala Phe Met Glu 
            100                 105                 110         


Ala Ala Val Tyr Gly Lys Val Lys Ala Leu Lys Phe Leu Tyr Lys Arg 
        115                 120                 125             


Gly Ala Asn Val Asn Leu Arg Arg Lys Thr Lys Glu Asp Gln Glu Arg 
    130                 135                 140                 


Leu Arg Lys Gly Gly Ala Thr Ala Leu Met Asp Ala Ala Glu Lys Gly 
145                 150                 155                 160 


His Val Glu Val Leu Lys Ile Leu Leu Asp Glu Met Gly Ala Asp Val 
                165                 170                 175     


Asn Ala Cys Asp Asn Met Gly Arg Asn Ala Leu Ile His Ala Leu Leu 
            180                 185                 190         


Ser Ser Asp Asp Ser Asp Val Glu Ala Ile Thr His Leu Leu Leu Asp 
        195                 200                 205             


His Gly Ala Asp Val Asn Val Arg Gly Glu Arg Gly Lys Thr Pro Leu 
    210                 215                 220                 


Ile Leu Ala Val Glu Lys Lys His Leu Gly Leu Val Gln Arg Leu Leu 
225                 230                 235                 240 


Glu Gln Glu His Ile Glu Ile Asn Asp Thr Asp Ser Asp Gly Lys Thr 
                245                 250                 255     


Ala Leu Leu Leu Ala Val Glu Leu Lys Leu Lys Lys Ile Ala Glu Leu 
            260                 265                 270         


Leu Cys Lys Arg Gly Ala Ser Thr Asp Cys Gly Asp Leu Val Met Thr 
        275                 280                 285             


Ala Arg Arg Asn Tyr Asp His Ser Leu Val Lys Val Leu Leu Ser His 
    290                 295                 300                 


Gly Ala Lys Glu Asp Phe His Pro Pro Ala Glu Asp Trp Lys Pro Gln 
305                 310                 315                 320 


Ser Ser His Trp Gly Ala Ala Leu Lys Asp Leu His Arg Ile Tyr Arg 
                325                 330                 335     


Pro Met Ile Gly Lys Leu Lys Phe Phe Ile Asp Glu Lys Tyr Lys Ile 
            340                 345                 350         


Ala Asp Thr Ser Glu Gly Gly Ile Tyr Leu Gly Phe Tyr Glu Lys Gln 
        355                 360                 365             


Glu Val Ala Val Lys Thr Phe Cys Glu Gly Ser Pro Arg Ala Gln Arg 
    370                 375                 380                 


Glu Val Ser Cys Leu Gln Ser Ser Arg Glu Asn Ser His Leu Val Thr 
385                 390                 395                 400 


Phe Tyr Gly Ser Glu Ser His Arg Gly His Leu Phe Val Cys Val Thr 
                405                 410                 415     


Leu Cys Glu Gln Thr Leu Glu Ala Cys Leu Asp Val His Arg Gly Glu 
            420                 425                 430         


Asp Val Glu Asn Glu Glu Asp Glu Phe Ala Arg Asn Val Leu Ser Ser 
        435                 440                 445             


Ile Phe Lys Ala Val Gln Glu Leu His Leu Ser Cys Gly Tyr Thr His 
    450                 455                 460                 


Gln Asp Leu Gln Pro Gln Asn Ile Leu Ile Asp Ser Lys Lys Ala Ala 
465                 470                 475                 480 


His Leu Ala Asp Phe Asp Lys Ser Ile Lys Trp Ala Gly Asp Pro Gln 
                485                 490                 495     


Glu Val Lys Arg Asp Leu Glu Asp Leu Gly Arg Leu Val Leu Tyr Val 
            500                 505                 510         


Val Lys Lys Gly Ser Ile Ser Phe Glu Asp Leu Lys Ala Gln Ser Asn 
        515                 520                 525             


Glu Glu Val Val Gln Leu Ser Pro Asp Glu Glu Thr Lys Asp Leu Ile 
    530                 535                 540                 


His Arg Leu Phe His Pro Gly Glu His Val Arg Asp Cys Leu Ser Asp 
545                 550                 555                 560 


Leu Leu Gly His Pro Phe Phe Trp Thr Trp Glu Ser Arg Tyr Arg Thr 
                565                 570                 575     


Leu Arg Asn Val Gly Asn Glu Ser Asp Ile Lys Thr Arg Lys Ser Glu 
            580                 585                 590         


Ser Glu Ile Leu Arg Leu Leu Gln Pro Gly Pro Ser Glu His Ser Lys 
        595                 600                 605             


Ser Phe Asp Lys Trp Thr Thr Lys Ile Asn Glu Cys Val Met Lys Lys 
    610                 615                 620                 


Met Asn Lys Phe Tyr Glu Lys Arg Gly Asn Phe Tyr Gln Asn Thr Val 
625                 630                 635                 640 


Gly Asp Leu Leu Lys Phe Ile Arg Asn Leu Gly Glu His Ile Asp Glu 
                645                 650                 655     


Glu Lys His Lys Lys Met Lys Leu Lys Ile Gly Asp Pro Ser Leu Tyr 
            660                 665                 670         


Phe Gln Lys Thr Phe Pro Asp Leu Val Ile Tyr Val Tyr Thr Lys Leu 
        675                 680                 685             


Gln Asn Thr Glu Tyr Arg Lys His Phe Pro Gln Thr His Ser Pro Asn 
    690                 695                 700                 


Lys Pro Gln Cys Asp Gly Ala Gly Gly Ala Ser Gly Leu Ala Ser Pro 
705                 710                 715                 720 


Gly Cys 
        


<210>  333
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNAseT2

<400>  333

Val Gln His Trp Pro Glu Thr Val Cys Glu Lys Ile Gln Asn Asp Cys 
1               5                   10                  15      


Arg Asp Pro Pro Asp Tyr Trp Thr Ile His Gly Leu Trp Pro Asp Lys 
            20                  25                  30          


Ser Glu Gly Cys Asn Arg Ser Trp Pro Phe Asn Leu Glu Glu Ile Lys 
        35                  40                  45              


Asp Leu Leu Pro Glu Met Arg Ala Tyr Trp Pro Asp Val Ile His Ser 
    50                  55                  60                  


Phe Pro Asn Arg Ser Arg Phe Trp Lys His Glu Trp Glu Lys His Gly 
65                  70                  75                  80  


Thr Cys Ala Ala Gln Val Asp Ala Leu Asn Ser Gln Lys Lys Tyr Phe 
                85                  90                  95      


Gly Arg Ser Leu Glu Leu Tyr Arg Glu Leu Asp Leu Asn Ser Val Leu 
            100                 105                 110         


Leu Lys Leu Gly Ile Lys Pro Ser Ile Asn Tyr Tyr Gln Val Ala Asp 
        115                 120                 125             


Phe Lys Asp Ala Leu Ala Arg Val Tyr Gly Val Ile Pro Lys Ile Gln 
    130                 135                 140                 


Cys Leu Pro Pro Ser Gln Asp Glu Glu Val Gln Thr Ile Gly Gln Ile 
145                 150                 155                 160 


Glu Leu Cys Leu Thr Lys Gln Asp Gln Gln Leu Gln Asn Cys Thr Glu 
                165                 170                 175     


Pro Gly Glu Gln Pro Ser Pro Lys Gln Glu Val Trp Leu Ala Asn Gly 
            180                 185                 190         


Ala Ala Glu Ser Arg Gly Leu Arg Val Cys Glu Asp Gly Pro Val Phe 
        195                 200                 205             


Tyr Pro Pro Pro Lys Lys Thr Lys His 
    210                 215         


<210>  334
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNAse11

<400>  334

Glu Ala Ser Glu Ser Thr Met Lys Ile Ile Lys Glu Glu Phe Thr Asp 
1               5                   10                  15      


Glu Glu Met Gln Tyr Asp Met Ala Lys Ser Gly Gln Glu Lys Gln Thr 
            20                  25                  30          


Ile Glu Ile Leu Met Asn Pro Ile Leu Leu Val Lys Asn Thr Ser Leu 
        35                  40                  45              


Ser Met Ser Lys Asp Asp Met Ser Ser Thr Leu Leu Thr Phe Arg Ser 
    50                  55                  60                  


Leu His Tyr Asn Asp Pro Lys Gly Asn Ser Ser Gly Asn Asp Lys Glu 
65                  70                  75                  80  


Cys Cys Asn Asp Met Thr Val Trp Arg Lys Val Ser Glu Ala Asn Gly 
                85                  90                  95      


Ser Cys Lys Trp Ser Asn Asn Phe Ile Arg Ser Ser Thr Glu Val Met 
            100                 105                 110         


Arg Arg Val His Arg Ala Pro Ser Cys Lys Phe Val Gln Asn Pro Gly 
        115                 120                 125             


Ile Ser Cys Cys Glu Ser Leu Glu Leu Glu Asn Thr Val Cys Gln Phe 
    130                 135                 140                 


Thr Thr Gly Lys Gln Phe Pro Arg Cys Gln Tyr His Ser Val Thr Ser 
145                 150                 155                 160 


Leu Glu Lys Ile Leu Thr Val Leu Thr Gly His Ser Leu Met Ser Trp 
                165                 170                 175     


Leu Val Cys Gly Ser Lys Leu 
            180             


<210>  335
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNAseT2-like


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  335

Xaa Leu Gly Gly Ala Asp Lys Arg Leu Arg Asp Asn His Glu Trp Lys 
1               5                   10                  15      


Lys Leu Ile Met Val Gln His Trp Pro Glu Thr Val Cys Glu Lys Ile 
            20                  25                  30          


Gln Asn Asp Cys Arg Asp Pro Pro Asp Tyr Trp Thr Ile His Gly Leu 
        35                  40                  45              


Trp Pro Asp Lys Ser Glu Gly Cys Asn Arg Ser Trp Pro Phe Asn Leu 
    50                  55                  60                  


Glu Glu Ile Lys Asp Leu Leu Pro Glu Met Arg Ala Tyr Trp Pro Asp 
65                  70                  75                  80  


Val Ile His Ser Phe Pro Asn Arg Ser Arg Phe Trp Lys His Glu Trp 
                85                  90                  95      


Glu Lys His Gly Thr Cys Ala Ala Gln Val Asp Ala Leu Asn Ser Gln 
            100                 105                 110         


Lys Lys Tyr Phe Gly Arg Ser Leu Glu Leu Tyr Arg Glu Leu Asp Leu 
        115                 120                 125             


Asn Ser Val Leu Leu Lys Leu Gly Ile Lys Pro Ser Ile Asn Tyr Tyr 
    130                 135                 140                 


Gln Thr Thr Glu Glu Asp Leu Asn Leu Asp Val Glu Pro Thr Thr Glu 
145                 150                 155                 160 


Asp Thr Ala Glu Glu Val Thr Ile His Val Leu Leu His Ser Ala Leu 
                165                 170                 175     


Phe Gly Glu Ile Gly Pro Arg Arg Trp 
            180                 185 


<210>  336
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNase1(K41R)

<400>  336

Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Arg Cys Arg Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


<210>  337
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNase1 (RNase1(K41R, D121E))

<400>  337

Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Arg Cys Arg Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val His Phe Glu Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


<210>  338
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNase1 (RNase1(K41R, D121E, H119N))

<400>  338

Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Arg Cys Arg Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val Asn Phe Glu Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


<210>  339
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (RNase1(H119N))

<400>  339

Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val Asn Phe Asp Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


<210>  340
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  (RNase1(R39D, N67D, N88A, G89D, R91D, H119N))

<400>  340

Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Asp Cys Lys Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asp Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Ala Asp Ser Asp Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val Asn Phe Asp Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


<210>  341
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNase1 (RNase1(R39D, N67D, N88A, G89D, R91D, H119N, K41R, D121E))

<400>  341

Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Asp Cys Arg Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asp Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Ala Asp Ser Asp Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val Asn Phe Glu Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


<210>  342
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNase1 (RNase1(R39D, N67D, N88A, G89D, R91D))

<400>  342

Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Asp Cys Lys Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asp Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Ala Asp Ser Asp Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


<210>  343
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Rnase1 (R39D, N67D, N88A, G89D, R91D, H119N, K41R, D121E)

<400>  343

Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Asp Cys Arg Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asp Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Ala Asp Ser Asp Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val Asn Phe Glu Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


<210>  344
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NOB1

<400>  344

Ala Pro Val Glu His Val Val Ala Asp Ala Gly Ala Phe Leu Arg His 
1               5                   10                  15      


Ala Ala Leu Gln Asp Ile Gly Lys Asn Ile Tyr Thr Ile Arg Glu Val 
            20                  25                  30          


Val Thr Glu Ile Arg Asp Lys Ala Thr Arg Arg Arg Leu Ala Val Leu 
        35                  40                  45              


Pro Tyr Glu Leu Arg Phe Lys Glu Pro Leu Pro Glu Tyr Val Arg Leu 
    50                  55                  60                  


Val Thr Glu Phe Ser Lys Lys Thr Gly Asp Tyr Pro Ser Leu Ser Ala 
65                  70                  75                  80  


Thr Asp Ile Gln Val Leu Ala Leu Thr Tyr Gln Leu Glu Ala Glu Phe 
                85                  90                  95      


Val Gly Val Ser His Leu Lys Gln Glu Pro Gln Lys Val Lys Val Ser 
            100                 105                 110         


Ser Ser Ile Gln His Pro Glu Thr Pro Leu His Ile Ser Gly Phe His 
        115                 120                 125             


Leu Pro Tyr Lys Pro Lys Pro Pro Gln Glu Thr Glu Lys Gly His Ser 
    130                 135                 140                 


Ala Cys Glu Pro Glu Asn Leu Glu Phe Ser Ser Phe Met Phe Trp Arg 
145                 150                 155                 160 


Asn Pro Leu Pro Asn Ile Asp His Glu Leu Gln Glu Leu Leu Ile Asp 
                165                 170                 175     


Arg Gly Glu Asp Val Pro Ser Glu Glu Glu Glu Glu Glu Glu Asn Gly 
            180                 185                 190         


Phe Glu Asp Arg Lys Asp Asp Ser Asp Asp Asp Gly Gly Gly Trp Ile 
        195                 200                 205             


Thr Pro Ser Asn Ile Lys Gln Ile Gln Gln Glu Leu Glu Gln Cys Asp 
    210                 215                 220                 


Val Pro Glu Asp Val Arg Val Gly Cys Leu Thr Thr Asp Phe Ala Met 
225                 230                 235                 240 


Gln Asn Val Leu Leu Gln Met Gly Leu His Val Leu Ala Val Asn Gly 
                245                 250                 255     


Met Leu Ile Arg Glu Ala Arg Ser Tyr Ile Leu Arg Cys His Gly Cys 
            260                 265                 270         


Phe Lys Thr Thr Ser Asp Met Ser Arg Val Phe Cys Ser His Cys Gly 
        275                 280                 285             


Asn Lys Thr Leu Lys Lys Val Ser Val Thr Val 
    290                 295                 


<210>  345
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ENDOV

<400>  345

Ala Phe Ser Gly Leu Gln Arg Val Gly Gly Val Asp Val Ser Phe Val 
1               5                   10                  15      


Lys Gly Asp Ser Val Arg Ala Cys Ala Ser Leu Val Val Leu Ser Phe 
            20                  25                  30          


Pro Glu Leu Glu Val Val Tyr Glu Glu Ser Arg Met Val Ser Leu Thr 
        35                  40                  45              


Ala Pro Tyr Val Ser Gly Phe Leu Ala Phe Arg Glu Val Pro Phe Leu 
    50                  55                  60                  


Leu Glu Leu Val Gln Gln Leu Arg Glu Lys Glu Pro Gly Leu Met Pro 
65                  70                  75                  80  


Gln Val Leu Leu Val Asp Gly Asn Gly Val Leu His His Arg Gly Phe 
                85                  90                  95      


Gly Val Ala Cys His Leu Gly Val Leu Thr Asp Leu Pro Cys Val Gly 
            100                 105                 110         


Val Ala Lys Lys Leu Leu Gln Val Asp Gly Leu Glu Asn Asn Ala Leu 
        115                 120                 125             


His Lys Glu Lys Ile Arg Leu Leu Gln Thr Arg Gly Asp Ser Phe Pro 
    130                 135                 140                 


Leu Leu Gly Asp Ser Gly Thr Val Leu Gly Met Ala Leu Arg Ser His 
145                 150                 155                 160 


Asp Arg Ser Thr Arg Pro Leu Tyr Ile Ser Val Gly His Arg Met Ser 
                165                 170                 175     


Leu Glu Ala Ala Val Arg Leu Thr Cys Cys Cys Cys Arg Phe Arg Ile 
            180                 185                 190         


Pro Glu Pro Val Arg Gln Ala Asp Ile Cys Ser Arg Glu His Ile Arg 
        195                 200                 205             


Lys Ser 
    210 


<210>  346
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ENDOG

<400>  346

Ala Glu Leu Pro Pro Val Pro Gly Gly Pro Arg Gly Pro Gly Glu Leu 
1               5                   10                  15      


Ala Lys Tyr Gly Leu Pro Gly Leu Ala Gln Leu Lys Ser Arg Glu Ser 
            20                  25                  30          


Tyr Val Leu Cys Tyr Asp Pro Arg Thr Arg Gly Ala Leu Trp Val Val 
        35                  40                  45              


Glu Gln Leu Arg Pro Glu Arg Leu Arg Gly Asp Gly Asp Arg Arg Glu 
    50                  55                  60                  


Cys Asp Phe Arg Glu Asp Asp Ser Val His Ala Tyr His Arg Ala Thr 
65                  70                  75                  80  


Asn Ala Asp Tyr Arg Gly Ser Gly Phe Asp Arg Gly His Leu Ala Ala 
                85                  90                  95      


Ala Ala Asn His Arg Trp Ser Gln Lys Ala Met Asp Asp Thr Phe Tyr 
            100                 105                 110         


Leu Ser Asn Val Ala Pro Gln Val Pro His Leu Asn Gln Asn Ala Trp 
        115                 120                 125             


Asn Asn Leu Glu Lys Tyr Ser Arg Ser Leu Thr Arg Ser Tyr Gln Asn 
    130                 135                 140                 


Val Tyr Val Cys Thr Gly Pro Leu Phe Leu Pro Arg Thr Glu Ala Asp 
145                 150                 155                 160 


Gly Lys Ser Tyr Val Lys Tyr Gln Val Ile Gly Lys Asn His Val Ala 
                165                 170                 175     


Val Pro Thr His Phe Phe Lys Val Leu Ile Leu Glu Ala Ala Gly Gly 
            180                 185                 190         


Gln Ile Glu Leu Arg Thr Tyr Val Met Pro Asn Ala Pro Val Asp Glu 
        195                 200                 205             


Ala Ile Pro Leu Glu Arg Phe Leu Val Pro Ile Glu Ser Ile Glu Arg 
    210                 215                 220                 


Ala Ser Gly Leu Leu Phe Val Pro Asn Ile Leu Ala Arg Ala Gly Ser 
225                 230                 235                 240 


Leu Lys Ala Ile Thr Ala Gly Ser Lys 
                245                 


<210>  347
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ENDOD1

<400>  347

Arg Leu Val Gly Glu Glu Glu Ala Gly Phe Gly Glu Cys Asp Lys Phe 
1               5                   10                  15      


Phe Tyr Ala Gly Thr Pro Pro Ala Gly Leu Ala Ala Asp Ser His Val 
            20                  25                  30          


Lys Ile Cys Gln Arg Ala Glu Gly Ala Glu Arg Phe Ala Thr Leu Tyr 
        35                  40                  45              


Ser Thr Arg Asp Arg Ile Pro Val Tyr Ser Ala Phe Arg Ala Pro Arg 
    50                  55                  60                  


Pro Ala Pro Gly Gly Ala Glu Gln Arg Trp Leu Val Glu Pro Gln Ile 
65                  70                  75                  80  


Asp Asp Pro Asn Ser Asn Leu Glu Glu Ala Ile Asn Glu Ala Glu Ala 
                85                  90                  95      


Ile Thr Ser Val Asn Ser Leu Gly Ser Lys Gln Ala Leu Asn Thr Asp 
            100                 105                 110         


Tyr Leu Asp Ser Asp Tyr Gln Arg Gly Gln Leu Tyr Pro Phe Ser Leu 
        115                 120                 125             


Ser Ser Asp Val Gln Val Ala Thr Phe Thr Leu Thr Asn Ser Ala Pro 
    130                 135                 140                 


Met Thr Gln Ser Phe Gln Glu Arg Trp Tyr Val Asn Leu His Ser Leu 
145                 150                 155                 160 


Met Asp Arg Ala Leu Thr Pro Gln Cys Gly Ser Gly Glu Asp Leu Tyr 
                165                 170                 175     


Ile Leu Thr Gly Thr Val Pro Ser Asp Tyr Arg Val Lys Asp Lys Val 
            180                 185                 190         


Ala Val Pro Glu Phe Val Trp Leu Ala Ala Cys Cys Ala Val Pro Gly 
        195                 200                 205             


Gly Gly Trp Ala Met Gly Phe Val Lys His Thr Arg Asp Ser Asp Ile 
    210                 215                 220                 


Ile Glu Asp Val Met Val Lys Asp Leu Gln Lys Leu Leu Pro Phe Asn 
225                 230                 235                 240 


Pro Gln Leu Phe Gln Asn Asn Cys Gly Glu Thr Glu Gln Asp Thr Glu 
                245                 250                 255     


Lys Met Lys Lys Ile Leu Glu Val Val Asn Gln Ile Gln Asp Glu Glu 
            260                 265                 270         


Arg Met Val Gln Ser Gln Lys Ser Ser Ser Pro Leu Ser Ser Thr Arg 
        275                 280                 285             


Ser Lys Arg Ser Thr Leu Leu Pro Pro Glu Ala Ser Glu Gly Ser Ser 
    290                 295                 300                 


Ser Phe Leu Gly Lys Leu Met Gly Phe Ile Ala Thr Pro Phe Ile Lys 
305                 310                 315                 320 


Leu Phe Gln Leu Ile Tyr Tyr Leu Val Val Ala Ile Leu Lys Asn Ile 
                325                 330                 335     


Val Tyr Phe Leu Trp Cys Val Thr Lys Gln Val Ile Asn Gly Ile Glu 
            340                 345                 350         


Ser Cys Leu Tyr Arg Leu Gly Ser Ala Thr Ile Ser Tyr Phe Met Ala 
        355                 360                 365             


Ile Gly Glu Glu Leu Val Ser Ile Pro Trp Lys Val Leu Lys Val Val 
    370                 375                 380                 


Ala Lys Val Ile Arg Ala Leu Leu Arg Ile Leu Cys Cys Leu Leu Lys 
385                 390                 395                 400 


Ala Ile Cys Arg Val Leu Ser Ile Pro Val Arg Val Leu Val Asp Val 
                405                 410                 415     


Ala Thr Phe Pro Val Tyr Thr Met Gly Ala Ile Pro Ile Val Cys Lys 
            420                 425                 430         


Asp Ile Ala Leu Gly Leu Gly Gly Thr Val Ser Leu Leu Phe Asp Thr 
        435                 440                 445             


Ala Phe Gly Thr Leu Gly Gly Leu Phe Gln Val Val Phe Ser Val Cys 
    450                 455                 460                 


Lys Arg Ile Gly Tyr Lys Val Thr Phe Asp Asn Ser Gly Glu Leu 
465                 470                 475                 


<210>  348
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hFEN1

<400>  348

Met Gly Ile Gln Gly Leu Ala Lys Leu Ile Ala Asp Val Ala Pro Ser 
1               5                   10                  15      


Ala Ile Arg Glu Asn Asp Ile Lys Ser Tyr Phe Gly Arg Lys Val Ala 
            20                  25                  30          


Ile Asp Ala Ser Met Ser Ile Tyr Gln Phe Leu Ile Ala Val Arg Gln 
        35                  40                  45              


Gly Gly Asp Val Leu Gln Asn Glu Glu Gly Glu Thr Thr Ser His Leu 
    50                  55                  60                  


Met Gly Met Phe Tyr Arg Thr Ile Arg Met Met Glu Asn Gly Ile Lys 
65                  70                  75                  80  


Pro Val Tyr Val Phe Asp Gly Lys Pro Pro Gln Leu Lys Ser Gly Glu 
                85                  90                  95      


Leu Ala Lys Arg Ser Glu Arg Arg Ala Glu Ala Glu Lys Gln Leu Gln 
            100                 105                 110         


Gln Ala Gln Ala Ala Gly Ala Glu Gln Glu Val Glu Lys Phe Thr Lys 
        115                 120                 125             


Arg Leu Val Lys Val Thr Lys Gln His Asn Asp Glu Cys Lys His Leu 
    130                 135                 140                 


Leu Ser Leu Met Gly Ile Pro Tyr Leu Asp Ala Pro Ser Glu Ala Glu 
145                 150                 155                 160 


Ala Ser Cys Ala Ala Leu Val Lys Ala Gly Lys Val Tyr Ala Ala Ala 
                165                 170                 175     


Thr Glu Asp Met Asp Cys Leu Thr Phe Gly Ser Pro Val Leu Met Arg 
            180                 185                 190         


His Leu Thr Ala Ser Glu Ala Lys Lys Leu Pro Ile Gln Glu Phe His 
        195                 200                 205             


Leu Ser Arg Ile Leu Gln Glu Leu Gly Leu Asn Gln Glu Gln Phe Val 
    210                 215                 220                 


Asp Leu Cys Ile Leu Leu Gly Ser Asp Tyr Cys Glu Ser Ile Arg Gly 
225                 230                 235                 240 


Ile Gly Pro Lys Arg Ala Val Asp Leu Ile Gln Lys His Lys Ser Ile 
                245                 250                 255     


Glu Glu Ile Val Arg Arg Leu Asp Pro Asn Lys Tyr Pro Val Pro Glu 
            260                 265                 270         


Asn Trp Leu His Lys Glu Ala His Gln Leu Phe Leu Glu Pro Glu Val 
        275                 280                 285             


Leu Asp Pro Glu Ser Val Glu Leu Lys Trp Ser Glu Pro Asn Glu Glu 
    290                 295                 300                 


Glu Leu Ile Lys Phe Met Cys Gly Glu Lys Gln Phe Ser Glu Glu Arg 
305                 310                 315                 320 


Ile Arg Ser Gly Val Lys Arg Leu Ser Lys Ser Arg Gln Gly Ser Thr 
                325                 330                 335     


Gln Gly Arg Leu Asp Asp Phe Phe Lys Val Thr Gly Ser Leu Ser Ser 
            340                 345                 350         


Ala Lys Arg Lys Glu Pro Glu Pro Lys Gly Ser Thr Lys Lys Lys Ala 
        355                 360                 365             


Lys Thr Gly Ala Ala Gly Lys Phe Lys Arg Gly Lys 
    370                 375                 380 


<210>  349
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  349

Met Glu Ser Gly Gln Pro Ala Arg Arg Ile Ala Met Ala Pro Leu Leu 
1               5                   10                  15      


Glu Tyr Glu Arg Gln Leu Val Leu Glu Leu Leu Asp Thr Asp Gly Leu 
            20                  25                  30          


Val Val Cys Ala Arg Gly Leu Gly Ala Asp Arg Leu Leu Tyr His Phe 
        35                  40                  45              


Leu Gln Leu His Cys His Pro Ala Cys Leu Val Leu Val Leu Asn Thr 
    50                  55                  60                  


Gln Pro Ala Glu Glu Glu Tyr Phe Ile Asn Gln Leu Lys Ile Glu Gly 
65                  70                  75                  80  


Val Glu His Leu Pro Arg Arg Val Thr Asn Glu Ile Thr Ser Asn Ser 
                85                  90                  95      


Arg Tyr Glu Val Tyr Thr Gln Gly Gly Val Ile Phe Ala Thr Ser Arg 
            100                 105                 110         


Ile Leu Val Val Asp Phe Leu Thr Asp Arg Ile Pro Ser Asp Leu Ile 
        115                 120                 125             


Thr Gly Ile Leu Val Tyr Arg Ala His Arg Ile Ile Glu Ser Cys Gln 
    130                 135                 140                 


Glu Ala Phe Ile Leu Arg Leu Phe Arg Gln Lys Asn Lys Arg Gly Phe 
145                 150                 155                 160 


Ile Lys Ala Phe Thr Asp Asn Ala Val Ala Phe Asp Thr Gly Phe Cys 
                165                 170                 175     


His Val Glu Arg Val Met Arg Asn Leu Phe Val Arg Lys Leu Tyr Leu 
            180                 185                 190         


Trp Pro Arg Phe His Val Ala Val Asn Ser Phe Leu Glu Gln His Lys 
        195                 200                 205             


Pro Glu Val Val Glu Ile His Val Ser Met Thr Pro Thr Met Leu Ala 
    210                 215                 220                 


Ile Gln Thr Ala Ile Leu Asp Ile Leu Asn Ala Cys Leu Lys Glu Leu 
225                 230                 235                 240 


Lys Cys His Asn Pro Ser Leu Glu Val Glu Asp Leu Ser Leu Glu Asn 
                245                 250                 255     


Ala Ile Gly Lys Pro Phe Asp Lys Thr Ile Arg His Tyr Leu Asp Pro 
            260                 265                 270         


Leu Trp His Gln Leu Gly Ala Lys Thr Lys Ser Leu Val Gln Asp Leu 
        275                 280                 285             


Lys Ile Leu Arg Thr Leu Leu Gln Tyr Leu Ser Gln Tyr Asp Cys Val 
    290                 295                 300                 


Thr Phe Leu Asn Leu Leu Glu Ser Leu Arg Ala Thr Glu Lys Ala Phe 
305                 310                 315                 320 


Gly Gln Asn Ser Gly Trp Leu Phe Leu Asp Ser Ser Thr Ser Met Phe 
                325                 330                 335     


Ile Asn Ala Arg Ala Arg Val Tyr His Leu Pro Asp Ala Lys Met Ser 
            340                 345                 350         


Lys Lys Glu Lys Ile Ser Glu Lys Met Glu Ile Lys Glu Gly Glu Gly 
        355                 360                 365             


Ile Leu Trp Gly 
    370         


<210>  350
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  350

Cys Ser Pro Gln Glu Ser Gly Met Thr Ala Leu Ser Ala Arg Met Leu 
1               5                   10                  15      


Thr Arg Ser Arg Ser Leu Gly Pro Gly Ala Gly Pro Arg Gly Cys Arg 
            20                  25                  30          


Glu Glu Pro Gly Pro Leu Arg Arg Arg Glu Ala Ala Ala Glu Ala Arg 
        35                  40                  45              


Lys Ser His Ser Pro Val Lys Arg Pro Arg Lys Ala Gln Arg Leu Arg 
    50                  55                  60                  


Val Ala Tyr Glu Gly Ser Asp Ser Glu Lys Gly Glu Gly Ala Glu Pro 
65                  70                  75                  80  


Leu Lys Val Pro Val Trp Glu Pro Gln Asp Trp Gln Gln Gln Leu Val 
                85                  90                  95      


Asn Ile Arg Ala Met Arg Asn Lys Lys Asp Ala Pro Val Asp His Leu 
            100                 105                 110         


Gly Thr Glu His Cys Tyr Asp Ser Ser Ala Pro Pro Lys Val Arg Arg 
        115                 120                 125             


Tyr Gln Val Leu Leu Ser Leu Met Leu Ser Ser Gln Thr Lys Asp Gln 
    130                 135                 140                 


Val Thr Ala Gly Ala Met Gln Arg Leu Arg Ala Arg Gly Leu Thr Val 
145                 150                 155                 160 


Asp Ser Ile Leu Gln Thr Asp Asp Ala Thr Leu Gly Lys Leu Ile Tyr 
                165                 170                 175     


Pro Val Gly Phe Trp Arg Ser Lys Val Lys Tyr Ile Lys Gln Thr Ser 
            180                 185                 190         


Ala Ile Leu Gln Gln His Tyr Gly Gly Asp Ile Pro Ala Ser Val Ala 
        195                 200                 205             


Glu Leu Val Ala Leu Pro Gly Val Gly Pro Lys Met Ala His Leu Ala 
    210                 215                 220                 


Met Ala Val Ala Trp Gly Thr Val Ser Gly Ile Ala Val Asp Thr His 
225                 230                 235                 240 


Val His Arg Ile Ala Asn Arg Leu Arg Trp Thr Lys Lys Ala Thr Lys 
                245                 250                 255     


Ser Pro Glu Glu Thr Arg Ala Ala Leu Glu Glu Trp Leu Pro Arg Glu 
            260                 265                 270         


Leu Trp His Glu Ile Asn Gly Leu Leu Val Gly Phe Gly Gln Gln Thr 
        275                 280                 285             


Cys Leu Pro Val His Pro Arg Cys His Ala Cys Leu Asn Gln Ala Leu 
    290                 295                 300                 


Cys Pro Ala Ala Gln Gly Leu 
305                 310     


<210>  351
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  351

Glu Ser Thr His Val Glu Phe Lys Arg Phe Thr Thr Lys Lys Val Ile 
1               5                   10                  15      


Pro Arg Ile Lys Glu Met Leu Pro His Tyr Val Ser Ala Phe Ala Asn 
            20                  25                  30          


Thr Gln Gly Gly Tyr Val Leu Ile Gly Val Asp Asp Lys Ser Lys Glu 
        35                  40                  45              


Val Val Gly Cys Lys Trp Glu Lys Val Asn Pro Asp Leu Leu Lys Lys 
    50                  55                  60                  


Glu Ile Glu Asn Cys Ile Glu Lys Leu Pro Thr Phe His Phe Cys Cys 
65                  70                  75                  80  


Glu Lys Pro Lys Val Asn Phe Thr Thr Lys Ile Leu Asn Val Tyr Gln 
                85                  90                  95      


Lys Asp Val Leu Asp Gly Tyr Val Cys Val Ile Gln Val Glu Pro Phe 
            100                 105                 110         


Cys Cys Val Val Phe Ala Glu Ala Pro Asp Ser Trp Ile Met Lys Asp 
        115                 120                 125             


Asn Ser Val Thr Arg Leu Thr Ala Glu Gln Trp Val Val Met Met Leu 
    130                 135                 140                 


Asp Thr Gln Ser Ala Pro Pro Ser Leu Val Thr Asp Tyr Asn Ser Cys 
145                 150                 155                 160 


Leu Ile Ser Ser Ala Ser Ser Ala Arg Lys Ser Pro Gly Tyr Pro Ile 
                165                 170                 175     


Lys Val His Lys Phe Lys Glu Ala Leu Gln 
            180                 185     


<210>  352
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  352

Thr Leu Gln Gly Thr Asn Thr Tyr Leu Val Gly Thr Gly Pro Arg Arg 
1               5                   10                  15      


Ile Leu Ile Asp Thr Gly Glu Pro Ala Ile Pro Glu Tyr Ile Ser Cys 
            20                  25                  30          


Leu Lys Gln Ala Leu Thr Glu Phe Asn Thr Ala Ile Gln Glu Ile Val 
        35                  40                  45              


Val Thr His Trp His Arg Asp His Ser Gly Gly Ile Gly Asp Ile Cys 
    50                  55                  60                  


Lys Ser Ile Asn Asn Asp Thr Thr Tyr Cys Ile Lys Lys Leu Pro Arg 
65                  70                  75                  80  


Asn Pro Gln Arg Glu Glu Ile Ile Gly Asn Gly Glu Gln Gln Tyr Val 
                85                  90                  95      


Tyr Leu Lys Asp Gly Asp Val Ile Lys Thr Glu Gly Ala Thr Leu Arg 
            100                 105                 110         


Val Leu Tyr Thr Pro Gly His Thr Asp Asp His Met Ala Leu Leu Leu 
        115                 120                 125             


Glu Glu Glu Asn Ala Ile Phe Ser Gly Asp Cys Ile Leu Gly Glu Gly 
    130                 135                 140                 


Thr Thr Val Phe Glu Asp Leu Tyr Asp Tyr Met Asn Ser Leu Lys Glu 
145                 150                 155                 160 


Leu Leu Lys Ile Lys Ala Asp Ile Ile Tyr Pro Gly His Gly Pro Val 
                165                 170                 175     


Ile His Asn Ala Glu Ala Lys Ile Gln Gln Tyr Ile Ser His Arg Asn 
            180                 185                 190         


Ile Arg Glu Gln Gln Ile Leu Thr Leu Phe Arg Glu Asn Phe Glu Lys 
        195                 200                 205             


Ser Phe Thr Val Met Glu Leu Val Lys Ile Ile Tyr Lys Asn Thr Pro 
    210                 215                 220                 


Glu Asn Leu His Glu Met Ala Lys His Asn Leu Leu Leu His Leu Lys 
225                 230                 235                 240 


Lys Leu Glu Lys Glu Gly Lys Ile Phe Ser Asn Thr Asp Pro Asp Lys 
                245                 250                 255     


Lys Trp Lys Ala His Leu 
            260         


<210>  353
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  353

Met Leu Arg Val Val Ser Trp Asn Ile Asn Gly Ile Arg Arg Pro Leu 
1               5                   10                  15      


Gln Gly Val Ala Asn Gln Glu Pro Ser Asn Cys Ala Ala Val Ala Val 
            20                  25                  30          


Gly Arg Ile Leu Asp Glu Leu Asp Ala Asp Ile Val Cys Leu Gln Glu 
        35                  40                  45              


Thr Lys Val Thr Arg Asp Ala Leu Thr Glu Pro Leu Ala Ile Val Glu 
    50                  55                  60                  


Gly Tyr Asn Ser Tyr Phe Ser Phe Ser Arg Asn Arg Ser Gly Tyr Ser 
65                  70                  75                  80  


Gly Val Ala Thr Phe Cys Lys Asp Asn Ala Thr Pro Val Ala Ala Glu 
                85                  90                  95      


Glu Gly Leu Ser Gly Leu Phe Ala Thr Gln Asn Gly Asp Val Gly Cys 
            100                 105                 110         


Tyr Gly Asn Met Asp Glu Phe Thr Gln Glu Glu Leu Arg Ala Leu Asp 
        115                 120                 125             


Ser Glu Gly Arg Ala Leu Leu Thr Gln His Lys Ile Arg Thr Trp Glu 
    130                 135                 140                 


Gly Lys Glu Lys Thr Leu Thr Leu Ile Asn Val Tyr Cys Pro His Ala 
145                 150                 155                 160 


Asp Pro Gly Arg Pro Glu Arg Leu Val Phe Lys Met Arg Phe Tyr Arg 
                165                 170                 175     


Leu Leu Gln Ile Arg Ala Glu Ala Leu Leu Ala Ala Gly Ser His Val 
            180                 185                 190         


Ile Ile Leu Gly Asp Leu Asn Thr Ala His Arg Pro Ile Asp His Trp 
        195                 200                 205             


Asp Ala Val Asn Leu Glu Cys Phe Glu Glu Asp Pro Gly Arg Lys Trp 
    210                 215                 220                 


Met Asp Ser Leu Leu Ser Asn Leu Gly Cys Gln Ser Ala Ser His Val 
225                 230                 235                 240 


Gly Pro Phe Ile Asp Ser Tyr Arg Cys Phe Gln Pro Lys Gln Glu Gly 
                245                 250                 255     


Ala Phe Thr Cys Trp Ser Ala Val Thr Gly Ala Arg His Leu Asn Tyr 
            260                 265                 270         


Gly Ser Arg Leu Asp Tyr Val Leu Gly Asp Arg Thr Leu Val Ile Asp 
        275                 280                 285             


Thr Phe Gln Ala Ser Phe Leu Leu Pro Glu Val Met Gly Ser Asp His 
    290                 295                 300                 


Cys Pro Val Gly Ala Val Leu Ser Val Ser Ser Val Pro Ala Lys Gln 
305                 310                 315                 320 


Cys Pro Pro Leu Cys Thr Arg Phe Leu Pro Glu Phe Ala Gly Thr Gln 
                325                 330                 335     


Leu Lys Ile Leu Arg Phe Leu Val Pro Leu Glu Gln Ser Pro Val Leu 
            340                 345                 350         


Glu Gln Ser Thr Leu Gln His Asn Asn Gln Thr Arg Val Gln Thr Cys 
        355                 360                 365             


Gln Asn Lys Ala Gln Val Arg Ser Thr Arg Pro Gln Pro Ser Gln Val 
    370                 375                 380                 


Gly Ser Ser Arg Gly Gln Lys Asn Leu Lys Ser Tyr Phe Gln Pro Ser 
385                 390                 395                 400 


Pro Ser Cys Pro Gln Ala Ser Pro Asp Ile Glu Leu Pro Ser Leu Pro 
                405                 410                 415     


Leu Met Ser Ala Leu Met Thr Pro Lys Thr Pro Glu Glu Lys Ala Val 
            420                 425                 430         


Ala Lys Val Val Lys Gly Gln Ala Lys Thr Ser Glu Ala Lys Asp Glu 
        435                 440                 445             


Lys Glu Leu Arg Thr Ser Phe Trp Lys Ser Val Leu Ala Gly Pro Leu 
    450                 455                 460                 


Arg Thr Pro Leu Cys Gly Gly His Arg Glu Pro Cys Val Met Arg Thr 
465                 470                 475                 480 


Val Lys Lys Pro Gly Pro Asn Leu Gly Arg Arg Phe Tyr Met Cys Ala 
                485                 490                 495     


Arg Pro Arg Gly Pro Pro Thr Asp Pro Ser Ser Arg Cys Asn Phe Phe 
            500                 505                 510         


Leu Trp Ser Arg Pro Ser 
        515             


<210>  354
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Leu Arg Val Val Ser Trp Asn Ile Asn Gly Ile Arg Arg Pro Leu 
1               5                   10                  15      


Gln Gly Val Ala Asn Gln Glu Pro Ser Asn Cys Ala Ala Val Ala Val 
            20                  25                  30          


Gly Arg Ile Leu Asp Glu Leu Asp Ala Asp Ile Val Cys Leu Gln Glu 
        35                  40                  45              


Thr Lys Val Thr Arg Asp Ala Leu Thr Glu Pro Leu Ala Ile Val Glu 
    50                  55                  60                  


Gly Tyr Asn Ser Tyr Phe Ser Phe Ser Arg Asn Arg Ser Gly Tyr Ser 
65                  70                  75                  80  


Gly Val Ala Thr Phe Cys Lys Asp Asn Ala Thr Pro Val Ala Ala Glu 
                85                  90                  95      


Glu Gly Leu Ser Gly Leu Phe Ala Thr Gln Asn Gly Asp Val Gly Cys 
            100                 105                 110         


Tyr Gly Asn Met Asp Glu Phe Thr Gln Glu Glu Leu Arg Ala Leu Asp 
        115                 120                 125             


Ser Glu Gly Arg Ala Leu Leu Thr Gln His Lys Ile Arg Thr Trp Glu 
    130                 135                 140                 


Gly Lys Glu Lys Thr Leu Thr Leu Ile Asn Val Tyr Cys Pro His Ala 
145                 150                 155                 160 


Asp Pro Gly Arg Pro Glu Arg Leu Val Phe Lys Met Arg Phe Tyr Arg 
                165                 170                 175     


Leu Leu Gln Ile Arg Ala Glu Ala Leu Leu Ala Ala Gly Ser His Val 
            180                 185                 190         


Ile Ile Leu Gly Asp Leu Asn Thr Ala His Arg Pro Ile Asp His Trp 
        195                 200                 205             


Asp Ala Val Asn Leu Glu Cys Phe Glu Glu Asp Pro Gly Arg Lys Trp 
    210                 215                 220                 


Met Asp Ser Leu Leu Ser Asn Leu Gly Cys Gln Ser Ala Ser His Val 
225                 230                 235                 240 


Gly Pro Phe Ile Asp Ser Tyr Arg Cys Phe Gln Pro Lys Gln Glu Gly 
                245                 250                 255     


Ala Phe Thr Cys Trp Ser Ala Val Thr Gly Ala Arg His Leu Asn Tyr 
            260                 265                 270         


Gly Ser Arg Leu Asp Tyr Val Leu Gly Asp Arg Thr Leu Val Ile Asp 
        275                 280                 285             


Thr Phe Gln Ala Ser Phe Leu Leu Pro Glu Val Met Gly Ser Asp His 
    290                 295                 300                 


Cys Pro Val Gly Ala Val Leu Ser Val Ser Ser Val Pro Ala Lys Gln 
305                 310                 315                 320 


Cys Pro Pro Leu Cys Thr Arg Phe Leu Pro Glu Phe Ala Gly Thr Gln 
                325                 330                 335     


Leu Lys Ile Leu Arg Phe Leu Val Pro Leu Glu Gln Ser Pro 
            340                 345                 350 


<210>  355
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  355

Pro Lys Arg Gly Lys Lys Gly Ala Val Ala Glu Asp Gly Asp Glu Leu 
1               5                   10                  15      


Arg Thr Glu Pro Glu Ala Lys Lys Ser Lys Thr Ala Ala Lys Lys Asn 
            20                  25                  30          


Asp Lys Glu Ala Ala Gly Glu Gly Pro Ala Leu Tyr Glu Asp Pro Pro 
        35                  40                  45              


Asp Gln Lys Thr Ser Pro Ser Gly Lys Pro Ala Thr Leu Lys Ile Cys 
    50                  55                  60                  


Ser Trp Asn Val Asp Gly Leu Arg Ala Trp Ile Lys Lys Lys Gly Leu 
65                  70                  75                  80  


Asp Trp Val Lys Glu Glu Ala Pro Asp Ile Leu Cys Leu Gln Glu Thr 
                85                  90                  95      


Lys Cys Ser Glu Asn Lys Leu Pro Ala Glu Leu Gln Glu Leu Pro Gly 
            100                 105                 110         


Leu Ser His Gln Tyr Trp Ser Ala Pro Ser Asp Lys Glu Gly Tyr Ser 
        115                 120                 125             


Gly Val Gly Leu Leu Ser Arg Gln Cys Pro Leu Lys Val Ser Tyr Gly 
    130                 135                 140                 


Ile Gly Asp Glu Glu His Asp Gln Glu Gly Arg Val Ile Val Ala Glu 
145                 150                 155                 160 


Phe Asp Ser Phe Val Leu Val Thr Ala Tyr Val Pro Asn Ala Gly Arg 
                165                 170                 175     


Gly Leu Val Arg Leu Glu Tyr Arg Gln Arg Trp Asp Glu Ala Phe Arg 
            180                 185                 190         


Lys Phe Leu Lys Gly Leu Ala Ser Arg Lys Pro Leu Val Leu Cys Gly 
        195                 200                 205             


Asp Leu Asn Val Ala His Glu Glu Ile Asp Leu Arg Asn Pro Lys Gly 
    210                 215                 220                 


Asn Lys Lys Asn Ala Gly Phe Thr Pro Gln Glu Arg Gln Gly Phe Gly 
225                 230                 235                 240 


Glu Leu Leu Gln Ala Val Pro Leu Ala Asp Ser Phe Arg His Leu Tyr 
                245                 250                 255     


Pro Asn Thr Pro Tyr Ala Tyr Thr Phe Trp Thr Tyr Met Met Asn Ala 
            260                 265                 270         


Arg Ser Lys Asn Val Gly Trp Arg Leu Asp Tyr Phe Leu Leu Ser 
        275                 280                 285         


<210>  356
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  356

Gln Asp Asn Ser Arg Tyr Thr His Phe Leu Thr Gln His Tyr Asp Ala 
1               5                   10                  15      


Lys Pro Gln Gly Arg Asp Asp Arg Tyr Cys Glu Ser Ile Met Arg Arg 
            20                  25                  30          


Arg Gly Leu Thr Ser Pro Cys Lys Asp Ile Asn Thr Phe Ile His Gly 
        35                  40                  45              


Asn Lys Arg Ser Ile Lys Ala Ile Cys Glu Asn Lys Asn Gly Asn Pro 
    50                  55                  60                  


His Arg Glu Asn Leu Arg Ile Ser Lys Ser Ser Phe Gln Val Thr Thr 
65                  70                  75                  80  


Cys Lys Leu His Gly Gly Ser Pro Trp Pro Pro Cys Gln Tyr Arg Ala 
                85                  90                  95      


Thr Ala Gly Phe Arg Asn Val Val Val Ala Cys Glu Asn Gly Leu Pro 
            100                 105                 110         


Val His Leu Asp Gln Ser Ile Phe Arg Arg Pro 
        115                 120             


<210>  357
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  357

Ser Ser Leu Ile Arg Arg Val Ile Ser Thr Ala Lys Ala Pro Gly Ala 
1               5                   10                  15      


Ile Gly Pro Tyr Ser Gln Ala Val Leu Val Asp Arg Thr Ile Tyr Ile 
            20                  25                  30          


Ser Gly Gln Ile Gly Met Asp Pro Ser Ser Gly Gln Leu Val Ser Gly 
        35                  40                  45              


Gly Val Ala Glu Glu Ala Lys Gln Ala Leu Lys Asn Met Gly Glu Ile 
    50                  55                  60                  


Leu Lys Ala Ala Gly Cys Asp Phe Thr Asn Val Val Lys Thr Thr Val 
65                  70                  75                  80  


Leu Leu Ala Asp Ile Asn Asp Phe Asn Thr Val Asn Glu Ile Tyr Lys 
                85                  90                  95      


Gln Tyr Phe Lys Ser Asn Phe Pro Ala Arg Ala Ala Tyr Gln Val Ala 
            100                 105                 110         


Ala Leu Pro Lys Gly Ser Arg Ile Glu Ile Glu Ala Val Ala Ile Gln 
        115                 120                 125             


Gly Pro Leu Thr Thr Ala Ser Leu 
    130                 135     


<210>  358
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  358

Gly Gly Gly Thr Pro Lys Ala Pro Asn Leu Glu Pro Pro Leu Pro Glu 
1               5                   10                  15      


Glu Glu Lys Glu Gly Ser Asp Leu Arg Pro Val Val Ile Asp Gly Ser 
            20                  25                  30          


Asn Val Ala Met Ser His Gly Asn Lys Glu Val Phe Ser Cys Arg Gly 
        35                  40                  45              


Ile Leu Leu Ala Val Asn Trp Phe Leu Glu Arg Gly His Thr Asp Ile 
    50                  55                  60                  


Thr Val Phe Val Pro Ser Trp Arg Lys Glu Gln Pro Arg Pro Asp Val 
65                  70                  75                  80  


Pro Ile Thr Asp Gln His Ile Leu Arg Glu Leu Glu Lys Lys Lys Ile 
                85                  90                  95      


Leu Val Phe Thr Pro Ser Arg Arg Val Gly Gly Lys Arg Val Val Cys 
            100                 105                 110         


Tyr Asp Asp Arg Phe Ile Val Lys Leu Ala Tyr Glu Ser Asp Gly Ile 
        115                 120                 125             


Val Val Ser Asn Asp Thr Tyr Arg Asp Leu Gln Gly Glu Arg Gln Glu 
    130                 135                 140                 


Trp Lys Arg Phe Ile Glu Glu Arg Leu Leu Met Tyr Ser Phe Val Asn 
145                 150                 155                 160 


Asp Lys Phe Met Pro Pro Asp Asp Pro Leu Gly Arg His Gly Pro Ser 
                165                 170                 175     


Leu Asp Asn Phe Leu Arg Lys Lys Pro Leu Thr Leu Glu 
            180                 185                 


<210>  359
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  359

Ser Gly Pro Cys Gly Glu Lys Pro Val Leu Glu Ala Ser Pro Thr Met 
1               5                   10                  15      


Ser Leu Trp Glu Phe Glu Asp Ser His Ser Arg Gln Gly Thr Pro Arg 
            20                  25                  30          


Pro Gly Gln Glu Leu Ala Ala Glu Glu Ala Ser Ala Leu Glu Leu Gln 
        35                  40                  45              


Met Lys Val Asp Phe Phe Arg Lys Leu Gly Tyr Ser Ser Thr Glu Ile 
    50                  55                  60                  


His Ser Val Leu Gln Lys Leu Gly Val Gln Ala Asp Thr Asn Thr Val 
65                  70                  75                  80  


Leu Gly Glu Leu Val Lys His Gly Thr Ala Thr Glu Arg Glu Arg Gln 
                85                  90                  95      


Thr Ser Pro Asp Pro Cys Pro Gln Leu Pro Leu Val Pro Arg Gly Gly 
            100                 105                 110         


Gly Thr Pro Lys Ala Pro Asn Leu Glu Pro Pro Leu Pro Glu Glu Glu 
        115                 120                 125             


Lys Glu Gly Ser Asp Leu Arg Pro Val Val Ile Asp Gly Ser Asn Val 
    130                 135                 140                 


Ala Met Ser His Gly Asn Lys Glu Val Phe Ser Cys Arg Gly Ile Leu 
145                 150                 155                 160 


Leu Ala Val Asn Trp Phe Leu Glu Arg Gly His Thr Asp Ile Thr Val 
                165                 170                 175     


Phe Val Pro Ser Trp Arg Lys Glu Gln Pro Arg Pro Asp Val Pro Ile 
            180                 185                 190         


Thr Asp Gln His Ile Leu Arg Glu Leu Glu Lys Lys Lys Ile Leu Val 
        195                 200                 205             


Phe Thr Pro Ser Arg Arg Val Gly Gly Lys Arg Val Val Cys Tyr Asp 
    210                 215                 220                 


Asp Arg Phe Ile Val Lys Leu Ala Tyr Glu Ser Asp Gly Ile Val Val 
225                 230                 235                 240 


Ser Asn Asp Thr Tyr Arg Asp Leu Gln Gly Glu Arg Gln Glu Trp Lys 
                245                 250                 255     


Arg Phe Ile Glu Glu Arg Leu Leu Met Tyr Ser Phe Val Asn Asp Lys 
            260                 265                 270         


Phe Met Pro Pro Asp Asp Pro Leu Gly Arg His Gly Pro Ser Leu Asp 
        275                 280                 285             


Asn Phe Leu Arg Lys Lys Pro Leu Thr Leu Glu His Arg Lys Gln Pro 
    290                 295                 300                 


Cys Pro Tyr Gly Arg Lys Cys Thr Tyr Gly Ile Lys Cys Arg Phe Phe 
305                 310                 315                 320 


His Pro Glu Arg Pro Ser Cys Pro Gln Arg Ser Val Ala Asp Glu Leu 
                325                 330                 335     


Arg Ala Asn Ala Leu Leu Ser Pro Pro Arg Ala Pro Ser Lys Asp Lys 
            340                 345                 350         


Asn Gly Arg Arg Pro Ser Pro Ser Ser Gln Ser Ser Ser Leu Leu Thr 
        355                 360                 365             


Glu Ser Glu Gln Cys Ser Leu Asp Gly Lys Lys Leu Gly Ala Gln Ala 
    370                 375                 380                 


Ser Pro Gly Ser Arg Gln Glu Gly Leu Thr Gln Thr Tyr Ala Pro Ser 
385                 390                 395                 400 


Gly Arg Ser Leu Ala Pro Ser Gly Gly Ser Gly Ser Ser Phe Gly Pro 
                405                 410                 415     


Thr Asp Trp Leu Pro Gln Thr Leu Asp Ser Leu Pro Tyr Val Ser Gln 
            420                 425                 430         


Asp Cys Leu Asp Ser Gly Ile Gly Ser Leu Glu Ser Gln Met Ser Glu 
        435                 440                 445             


Leu Trp Gly Val Arg Gly Gly Gly Pro Gly Glu Pro Gly Pro Pro Arg 
    450                 455                 460                 


Ala Pro Tyr Thr Gly Tyr Ser Pro Tyr Gly Ser Glu Leu Pro Ala Thr 
465                 470                 475                 480 


Ala Ala Phe Ser Ala Phe Gly Arg Ala Met Gly Ala Gly His Phe Ser 
                485                 490                 495     


Val Pro Ala Asp Tyr Pro Pro Ala Pro Pro Ala Phe Pro Pro Arg Glu 
            500                 505                 510         


Tyr Trp Ser Glu Pro Tyr Pro Leu Pro Pro Pro Thr Ser Val Leu Gln 
        515                 520                 525             


Glu Pro Pro Val Gln Ser Pro Gly Ala Gly Arg Ser Pro Trp Gly Arg 
    530                 535                 540                 


Ala Gly Ser Leu Ala Lys Glu Gln Ala Ser Val Tyr Thr Lys Leu Cys 
545                 550                 555                 560 


Gly Val Phe Pro Pro His Leu Val Glu Ala Val Met Gly Arg Phe Pro 
                565                 570                 575     


Gln Leu Leu Asp Pro Gln Gln Leu Ala Ala Glu Ile Leu Ser Tyr Lys 
            580                 585                 590         


Ser Gln His Pro Ser Glu 
        595             


<210>  360
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  360

Ser Ser Leu Ile Arg Arg Val Ile Ser Thr Ala Lys Ala Pro Gly Ala 
1               5                   10                  15      


Ile Gly Pro Tyr Ser Gln Ala Val Leu Val Asp Arg Thr Ile Tyr Ile 
            20                  25                  30          


Ser Gly Gln Ile Gly Met Asp Pro Ser Ser Gly Gln Leu Val Ser Gly 
        35                  40                  45              


Gly Val Ala Glu Glu Ala Lys Gln Ala Leu Lys Asn Met Gly Glu Ile 
    50                  55                  60                  


Leu Lys Ala Ala Gly Cys Asp Phe Thr Asn Val Val Lys Thr Thr Val 
65                  70                  75                  80  


Leu Leu Ala Asp Ile Asn Asp Phe Asn Thr Val Asn Glu Ile Tyr Lys 
                85                  90                  95      


Gln Tyr Phe Lys Ser Asn Phe Pro Ala Arg Ala Ala Tyr Gln Val Ala 
            100                 105                 110         


Ala Leu Pro Lys Gly Ser Arg Ile Glu Ile Glu Ala Val Ala Ile Gln 
        115                 120                 125             


Gly Pro Leu Thr Thr Ala Ser Leu 
    130                 135     


<210>  361
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  361

Glu Ala Leu Phe Phe Pro Ser Gln Val Thr Cys Thr Glu Ala Leu Leu 
1               5                   10                  15      


Arg Ala Pro Gly Ala Glu Leu Ala Glu Leu Pro Glu Gly Cys Pro Cys 
            20                  25                  30          


Gly Leu Pro His Gly Glu Ser Ala Leu Ser Arg Leu Leu Arg Ala Leu 
        35                  40                  45              


Leu Ala Ala Arg Ala Ser Leu Asp Leu Cys Leu Phe Ala Phe Ser Ser 
    50                  55                  60                  


Pro Gln Leu Gly Arg Ala Val Gln Leu Leu His Gln Arg Gly Val Arg 
65                  70                  75                  80  


Val Arg Val Val Thr Asp Cys Asp Tyr Met Ala Leu Asn Gly Ser Gln 
                85                  90                  95      


Ile Gly Leu Leu Arg Lys Ala Gly Ile Gln Val Arg His Asp Gln Asp 
            100                 105                 110         


Pro Gly Tyr Met His His Lys Phe Ala Ile Val Asp Lys Arg Val Leu 
        115                 120                 125             


Ile Thr Gly Ser Leu Asn Trp Thr Thr Gln Ala Ile Gln Asn Asn Arg 
    130                 135                 140                 


Glu Asn Val Leu Ile Thr Glu Asp Asp Glu Tyr Val Arg Leu Phe Leu 
145                 150                 155                 160 


Glu Glu Phe Glu Arg Ile Trp Glu Gln Phe Asn Pro Thr Lys Tyr Thr 
                165                 170                 175     


Phe Phe Pro Pro Lys Lys Ser His Gly Ser Cys Ala Pro Pro Val Ser 
            180                 185                 190         


Arg Ala Gly Gly Arg Leu Leu Ser Trp His Arg Thr Cys Gly Thr Ser 
        195                 200                 205             


Ser Glu Ser Gln Thr 
    210             


<210>  362
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  362

Lys Ala Arg Tyr Lys Thr Leu Glu Pro Arg Gly Tyr Ser Leu Leu Ile 
1               5                   10                  15      


Arg Gly Leu Ile His Ser Asp Arg Trp Arg Glu Ala Leu Leu Leu Leu 
            20                  25                  30          


Glu Asp Ile Lys Lys Val Ile Thr Pro Ser Lys Lys Asn Tyr Asn Asp 
        35                  40                  45              


Cys Ile Gln Gly Ala Leu Leu His Gln Asp Val Asn Thr Ala Trp Asn 
    50                  55                  60                  


Leu Tyr Gln Glu Leu Leu Gly His Asp Ile Val Pro Met Leu Glu Thr 
65                  70                  75                  80  


Leu Lys Ala Phe Phe Asp Phe Gly Lys Asp Ile Lys Asp Asp Asn Tyr 
                85                  90                  95      


Ser Asn Lys Leu Leu Asp Ile Leu Ser Tyr Leu Arg Asn Asn Gln Leu 
            100                 105                 110         


Tyr Pro Gly Glu Ser Phe Ala His Ser Ile Lys Thr Trp Phe Glu Ser 
        115                 120                 125             


Val Pro Gly Lys Gln Trp Lys Gly Gln Phe Thr Thr Val Arg Lys Ser 
    130                 135                 140                 


Gly Gln Cys Ser Gly Cys Gly Lys Thr Ile Glu Ser Ile Gln Leu Ser 
145                 150                 155                 160 


Pro Glu Glu Tyr Glu Cys Leu Lys Gly Lys Ile Met Arg Asp Val Ile 
                165                 170                 175     


Asp Gly Gly Asp Gln Tyr Arg Lys Thr Thr Pro Gln Glu Leu Lys Arg 
            180                 185                 190         


Phe Glu Asn Phe Ile Lys Ser Arg Pro Pro Phe Asp Val Val Ile Asp 
        195                 200                 205             


Gly Leu Asn Val Ala Lys Met Phe Pro Lys Val Arg Glu Ser Gln Leu 
    210                 215                 220                 


Leu Leu Asn Val Val Ser Gln Leu Ala Lys Arg Asn Leu Arg Leu Leu 
225                 230                 235                 240 


Val Leu Gly Arg Lys His Met Leu Arg Arg Ser Ser Gln Trp Ser Arg 
                245                 250                 255     


Asp Glu Met Glu Glu Val Gln Lys Gln Ala Ser Cys Phe Phe Ala Asp 
            260                 265                 270         


Asp Ile Ser Glu Asp Asp Pro Phe Leu Leu Tyr Ala Thr Leu His Ser 
        275                 280                 285             


Gly Asn His Cys Arg Phe Ile Thr Arg Asp Leu Met Arg Asp His Lys 
    290                 295                 300                 


Ala Cys Leu Pro Asp Ala Lys Thr Gln Arg Leu Phe Phe Lys Trp Gln 
305                 310                 315                 320 


Gln Gly His Gln Leu Ala Ile Val Asn Arg Phe Pro Gly Ser Lys Leu 
                325                 330                 335     


Thr Phe Gln Arg Ile Leu Ser Tyr Asp Thr Val Val Gln Thr Thr Gly 
            340                 345                 350         


Asp Ser Trp His Ile Pro Tyr Asp Glu Asp Leu Val Glu Arg Cys Ser 
        355                 360                 365             


Cys Glu Val Pro Thr Lys Trp Leu Cys Leu His Gln Lys Thr 
    370                 375                 380         


<210>  363
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  363

Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Thr Tyr Ala Gly Leu 
1               5                   10                  15      


Gln Leu Val Val Val Ile Leu Pro Gly Lys Thr Pro Val Tyr Ala Glu 
            20                  25                  30          


Val Lys Arg Val Gly Asp Thr Val Leu Gly Met Ala Thr Gln Cys Val 
        35                  40                  45              


Gln Met Lys Asn Val Gln Arg Thr Thr Pro Gln Thr Leu Ser Asn Leu 
    50                  55                  60                  


Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Val Asn Asn Ile Leu Leu 
65                  70                  75                  80  


Pro Gln Gly Arg Pro Pro Val Phe Gln Gln Pro Val Ile Phe Leu Gly 
                85                  90                  95      


Ala Asp Val Thr His Pro Pro Ala Gly Asp Gly Lys Lys Pro Ser Ile 
            100                 105                 110         


Ala Ala Val Val Gly Ser Met Asp Ala His Pro Asn Arg Tyr Cys Ala 
        115                 120                 125             


Thr Val Arg Val Gln Gln His Arg Gln Glu Ile Ile Gln Asp Leu Ala 
    130                 135                 140                 


Ala Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys Ser Thr Arg Phe 
145                 150                 155                 160 


Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp Gly Val Ser Glu Gly Gln 
                165                 170                 175     


Phe Gln Gln Val Leu His His Glu Leu Leu Ala Ile Arg Glu Ala Cys 
            180                 185                 190         


Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly Ile Thr Phe Ile Val Val 
        195                 200                 205             


Gln Lys Arg His His Thr Arg Leu Phe Cys Thr Asp Lys Asn Glu Arg 
    210                 215                 220                 


Val Gly Lys Ser Gly Asn Ile Pro Ala Gly Thr Thr Val Asp Thr Lys 
225                 230                 235                 240 


Ile Thr His Pro Thr Glu Phe Asp Phe Tyr Leu Cys Ser His Ala Gly 
                245                 250                 255     


Ile Gln Gly Thr Ser Arg Pro Ser His Tyr His Val Leu Trp Asp Asp 
            260                 265                 270         


Asn Arg Phe Ser Ser Asp Glu Leu Gln Ile Leu Thr Tyr Gln Leu Cys 
        275                 280                 285             


His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile Pro Ala Pro Ala 
    290                 295                 300                 


Tyr Tyr Ala His Leu Val Ala Phe Arg Ala Arg Tyr His Leu Val Asp 
305                 310                 315                 320 


Lys Glu His Asp Ser Ala Glu Gly Ser His Thr Ser Gly Gln Ser Asn 
                325                 330                 335     


Gly Arg Asp His Gln Ala Leu Ala Lys Ala Val Gln Val His Gln Asp 
            340                 345                 350         


Thr Leu Arg Thr Met Tyr Phe Ala 
        355                 360 


<210>  364
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  364

Gln Gly Ala Glu Gly Ala Leu Thr Gly Lys Gln Pro Asp Gly Ser Ala 
1               5                   10                  15      


Glu Lys Ala Val Leu Glu Gln Phe Gly Phe Pro Leu Thr Gly Thr Glu 
            20                  25                  30          


Ala Arg Cys Tyr Thr Asn His Ala Leu Ser Tyr Asp Gln Ala Lys Arg 
        35                  40                  45              


Val Pro Arg Trp Val Leu Glu His Ile Ser Lys Ser Lys Ile Met Gly 
    50                  55                  60                  


Asp Ala Asp Arg Lys His Cys Lys Phe Lys Pro Asp Pro Asn Ile Pro 
65                  70                  75                  80  


Pro Thr Phe Ser Ala Phe Asn Glu Asp Tyr Val Gly Ser Gly Trp Ser 
                85                  90                  95      


Arg Gly His Met Ala Pro Ala Gly Asn Asn Lys Phe Ser Ser Lys Ala 
            100                 105                 110         


Met Ala Glu Thr Phe Tyr Leu Ser Asn Ile Val Pro Gln Asp Phe Asp 
        115                 120                 125             


Asn Asn Ser Gly Tyr Trp Asn Arg Ile Glu Met Tyr Cys Arg Glu Leu 
    130                 135                 140                 


Thr Glu Arg Phe Glu Asp Val Trp Val Val Ser Gly Pro Leu Thr Leu 
145                 150                 155                 160 


Pro Gln Thr Arg Gly Asp Gly Lys Lys Ile Val Ser Tyr Gln Val Ile 
                165                 170                 175     


Gly Glu Asp Asn Val Ala Val Pro Ser His Leu Tyr Lys Val Ile Leu 
            180                 185                 190         


Ala Arg Arg Ser Ser Val Ser Thr Glu Pro Leu Ala Leu Gly Ala Phe 
        195                 200                 205             


Val Val Pro Asn Glu Ala Ile Gly Phe Gln Pro Gln Leu Thr Glu Phe 
    210                 215                 220                 


Gln Val Ser Leu Gln Asp Leu Glu Lys Leu Ser Gly Leu Val Phe Phe 
225                 230                 235                 240 


Pro His Leu Asp Arg Thr Ser Asp Ile Arg Asn Ile Cys Ser Val Asp 
                245                 250                 255     


Thr Cys Lys Leu Leu Asp Phe Gln Glu Phe Thr Leu Tyr Leu Ser Thr 
            260                 265                 270         


Arg Lys Ile Glu Gly Ala Arg Ser Val Leu Arg Leu Glu Lys Ile Met 
        275                 280                 285             


Glu Asn Leu Lys Asn Ala Glu Ile Glu Pro Asp Asp Tyr Phe Met Ser 
    290                 295                 300                 


Arg Tyr Glu Lys Lys Leu Glu Glu Leu Lys Ala Lys Glu Gln Ser Gly 
305                 310                 315                 320 


Thr Gln Ile Arg Lys Pro Ser 
                325         


<210>  365
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  365

Glu His Pro Ser Lys Met Glu Phe Phe Gln Lys Leu Gly Tyr Asp Arg 
1               5                   10                  15      


Glu Asp Val Leu Arg Val Leu Gly Lys Leu Gly Glu Gly Ala Leu Val 
            20                  25                  30          


Asn Asp Val Leu Gln Glu Leu Ile Arg Thr Gly Ser Arg Pro Gly Ala 
        35                  40                  45              


Leu Glu His Pro Ala Ala Pro Arg Leu Val Pro Arg Gly Ser Cys Gly 
    50                  55                  60                  


Val Pro Asp Ser Ala Gln Arg Gly Pro Gly Thr Ala Leu Glu Glu Asp 
65                  70                  75                  80  


Phe Arg Thr Leu Ala Ser Ser Leu Arg Pro Ile Val Ile Asp Gly Ser 
                85                  90                  95      


Asn Val Ala Met Ser His Gly Asn Lys Glu Thr Phe Ser Cys Arg Gly 
            100                 105                 110         


Ile Lys Leu Ala Val Asp Trp Phe Arg Asp Arg Gly His Thr Tyr Ile 
        115                 120                 125             


Lys Val Phe Val Pro Ser Trp Arg Lys Asp Pro Pro Arg Ala Asp Thr 
    130                 135                 140                 


Pro Ile Arg Glu Gln His Val Leu Ala Glu Leu Glu Arg Gln Ala Val 
145                 150                 155                 160 


Leu Val Tyr Thr Pro Ser Arg Lys Val His Gly Lys Arg Leu Val Cys 
                165                 170                 175     


Tyr Asp Asp Arg Tyr Ile Val Lys Val Ala Tyr Glu Gln Asp Gly Val 
            180                 185                 190         


Ile Val Ser Asn Asp Asn Tyr Arg Asp Leu Gln Ser Glu Asn Pro Glu 
        195                 200                 205             


Trp Lys Trp Phe Ile Glu Gln Arg Leu Leu Met Phe Ser Phe Val Asn 
    210                 215                 220                 


Asp Arg Phe Met Pro Pro Asp Asp Pro Leu Gly Arg His Gly Pro Ser 
225                 230                 235                 240 


Leu Ser Asn Phe Leu Ser Arg Lys Pro Lys Pro Pro Glu Pro Ser Trp 
                245                 250                 255     


Gln His Cys Pro Tyr Gly Lys Lys Cys Thr Tyr Gly Ile Lys Cys Lys 
            260                 265                 270         


Phe Tyr His Pro Glu Arg Pro His His Ala Gln Leu Ala Val Ala Asp 
        275                 280                 285             


Glu Leu Arg Ala Lys Thr Gly Ala Arg Pro Gly Ala Gly Ala Glu Glu 
    290                 295                 300                 


Gln Arg Pro Pro Arg Ala Pro Gly Gly Ser Ala Gly Ala Arg Ala Ala 
305                 310                 315                 320 


Pro Arg Glu Pro Phe Ala His Ser Leu Pro Pro Ala Arg Gly Ser Pro 
                325                 330                 335     


Asp Leu Ala Ala Leu Arg Gly Ser Phe Ser Arg Leu Ala Phe Ser Asp 
            340                 345                 350         


Asp Leu Gly Pro Leu Gly Pro Pro Leu Pro Val Pro Ala Cys Ser Leu 
        355                 360                 365             


Thr Pro Arg Leu Gly Gly Pro Asp Trp Val Ser Ala Gly Gly Arg Val 
    370                 375                 380                 


Pro Gly Pro Leu Ser Leu Pro Ser Pro Glu Ser Gln Phe Ser Pro Gly 
385                 390                 395                 400 


Asp Leu Pro Pro Pro Pro Gly Leu Gln Leu Gln Pro Arg Gly Glu His 
                405                 410                 415     


Arg Pro Arg Asp Leu His Gly Asp Leu Leu Ser Pro Arg Arg Pro Pro 
            420                 425                 430         


Asp Asp Pro Trp Ala Arg Pro Pro Arg Ser Asp Arg Phe Pro Gly Arg 
        435                 440                 445             


Ser Val Trp Ala Glu Pro Ala Trp Gly Asp Gly Ala Thr Gly Gly Leu 
    450                 455                 460                 


Ser Val Tyr Ala Thr Glu Asp Asp Glu Gly Asp Ala Arg Ala Arg Ala 
465                 470                 475                 480 


Arg Ile Ala Leu Tyr Ser Val Phe Pro Arg Asp Gln Val Asp Arg Val 
                485                 490                 495     


Met Ala Ala Phe Pro Glu Leu Ser Asp Leu Ala Arg Leu Ile Leu Leu 
            500                 505                 510         


Val Gln Arg Cys Gln Ser Ala Gly Ala Pro Leu Gly Lys Pro 
        515                 520                 525     


<210>  366
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  366

Arg Gln Gln Gln Pro Gln Val Val Glu Lys Gln Gln Glu Thr Pro Leu 
1               5                   10                  15      


Ala Pro Ala Asp Phe Ala His Ile Ser Gln Asp Ala Gln Ser Leu His 
            20                  25                  30          


Ser Gly Ala Ser Arg Arg Ser Gln Lys Arg Leu Gln Ser Pro Ser Lys 
        35                  40                  45              


Gln Ala Gln Pro Leu Asp Asp Pro Glu Ala Glu Gln Leu Thr Val Val 
    50                  55                  60                  


Gly Lys Ile Ser Phe Asn Pro Lys Asp Val Leu Gly Arg Gly Ala Gly 
65                  70                  75                  80  


Gly Thr Phe Val Phe Arg Gly Gln Phe Glu Gly Arg Ala Val Ala Val 
                85                  90                  95      


Lys Arg Leu Leu Arg Glu Cys Phe Gly Leu Val Arg Arg Glu Val Gln 
            100                 105                 110         


Leu Leu Gln Glu Ser Asp Arg His Pro Asn Val Leu Arg Tyr Phe Cys 
        115                 120                 125             


Thr Glu Arg Gly Pro Gln Phe His Tyr Ile Ala Leu Glu Leu Cys Arg 
    130                 135                 140                 


Ala Ser Leu Gln Glu Tyr Val Glu Asn Pro Asp Leu Asp Arg Gly Gly 
145                 150                 155                 160 


Leu Glu Pro Glu Val Val Leu Gln Gln Leu Met Ser Gly Leu Ala His 
                165                 170                 175     


Leu His Ser Leu His Ile Val His Arg Asp Leu Lys Pro Gly Asn Ile 
            180                 185                 190         


Leu Ile Thr Gly Pro Asp Ser Gln Gly Leu Gly Arg Val Val Leu Ser 
        195                 200                 205             


Asp Phe Gly Leu Cys Lys Lys Leu Pro Ala Gly Arg Cys Ser Phe Ser 
    210                 215                 220                 


Leu His Ser Gly Ile Pro Gly Thr Glu Gly Trp Met Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gln Leu Leu Pro Pro Asp Ser Pro Thr Ser Ala Val Asp Ile Phe 
                245                 250                 255     


Ser Ala Gly Cys Val Phe Tyr Tyr Val Leu Ser Gly Gly Ser His Pro 
            260                 265                 270         


Phe Gly Asp Ser Leu Tyr Arg Gln Ala Asn Ile Leu Thr Gly Ala Pro 
        275                 280                 285             


Cys Leu Ala His Leu Glu Glu Glu Val His Asp Lys Val Val Ala Arg 
    290                 295                 300                 


Asp Leu Val Gly Ala Met Leu Ser Pro Leu Pro Gln Pro Arg Pro Ser 
305                 310                 315                 320 


Ala Pro Gln Val Leu Ala His Pro Phe Phe Trp Ser Arg Ala Lys Gln 
                325                 330                 335     


Leu Gln Phe Phe Gln Asp Val Ser Asp Trp Leu Glu Lys Glu Ser Glu 
            340                 345                 350         


Gln Glu Pro Leu Val Arg Ala Leu Glu Ala Gly Gly Cys Ala Val Val 
        355                 360                 365             


Arg Asp Asn Trp His Glu His Ile Ser Met Pro Leu Gln Thr Asp Leu 
    370                 375                 380                 


Arg Lys Phe Arg Ser Tyr Lys Gly Thr Ser Val Arg Asp Leu Leu Arg 
385                 390                 395                 400 


Ala Val Arg Asn Lys Lys His His Tyr Arg Glu Leu Pro Val Glu Val 
                405                 410                 415     


Arg Gln Ala Leu Gly Gln Val Pro Asp Gly Phe Val Gln Tyr Phe Thr 
            420                 425                 430         


Asn Arg Phe Pro Arg Leu Leu Leu His Thr His Arg Ala Met Arg Ser 
        435                 440                 445             


Cys Ala Ser Glu Ser Leu Phe Leu Pro Tyr Tyr Pro Pro Asp Ser Glu 
    450                 455                 460                 


Ala Arg Arg Pro Cys Pro Gly Ala Thr Gly Arg 
465                 470                 475 


<210>  367
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  367

Lys Leu Val Arg Lys Asn Ile Glu Lys Asp Asn Ala Gly Gln Val Thr 
1               5                   10                  15      


Leu Val Pro Glu Glu Pro Glu Asp Met Trp His Thr Tyr Asn Leu Val 
            20                  25                  30          


Gln Val Gly Asp Ser Leu Arg Ala Ser Thr Ile Arg Lys Val Gln Thr 
        35                  40                  45              


Glu Ser Ser Thr Gly Ser Val Gly Ser Asn Arg Val Arg Thr Thr Leu 
    50                  55                  60                  


Thr Leu Cys Val Glu Ala Ile Asp Phe Asp Ser Gln Ala Cys Gln Leu 
65                  70                  75                  80  


Arg Val Lys Gly Thr Asn Ile Gln Glu Asn Glu Tyr Val Lys Met Gly 
                85                  90                  95      


Ala Tyr His Thr Ile Glu Leu Glu Pro Asn Arg Gln Phe Thr Leu Ala 
            100                 105                 110         


Lys Lys Gln Trp Asp Ser Val Val Leu Glu Arg Ile Glu Gln Ala Cys 
        115                 120                 125             


Asp Pro Ala Trp Ser Ala Asp Val Ala Ala Val Val Met Gln Glu Gly 
    130                 135                 140                 


Leu Ala His Ile Cys Leu Val Thr Pro Ser Met Thr Leu Thr Arg Ala 
145                 150                 155                 160 


Lys Val Glu Val Asn Ile Pro Arg Lys Arg Lys Gly Asn Cys Ser Gln 
                165                 170                 175     


His Asp Arg Ala Leu Glu Arg Phe Tyr Glu Gln Val Val Gln Ala Ile 
            180                 185                 190         


Gln Arg His Ile His Phe Asp Val Val Lys Cys Ile Leu Val Ala Ser 
        195                 200                 205             


Pro Gly Phe Val Arg Glu Gln Phe Cys Asp Tyr Leu Phe Gln Gln Ala 
    210                 215                 220                 


Val Lys Thr Asp Asn Lys Leu Leu Leu Glu Asn Arg Ser Lys Phe Leu 
225                 230                 235                 240 


Gln Val His Ala Ser Ser Gly His Lys Tyr Ser Leu Lys Glu Ala Leu 
                245                 250                 255     


Cys Asp Pro Thr Val Ala Ser Arg Leu Ser Asp Thr Lys Ala Ala Gly 
            260                 265                 270         


Glu Val Lys Ala Leu Asp Asp Phe Tyr Lys Met Leu Gln His Glu Pro 
        275                 280                 285             


Asp Arg Ala Phe Tyr Gly Leu Lys Gln Val Glu Lys Ala Asn Glu Ala 
    290                 295                 300                 


Met Ala Ile Asp Thr Leu Leu Ile Ser Asp Glu Leu Phe Arg His Gln 
305                 310                 315                 320 


Asp Val Ala Thr Arg Ser Arg Tyr Val Arg Leu Val Asp Ser Val Lys 
                325                 330                 335     


Glu Asn Ala Gly Thr Val Arg Ile Phe Ser Ser Leu His Val Ser Gly 
            340                 345                 350         


Glu Gln Leu Ser Gln Leu Thr Gly Val Ala Ala Ile Leu Arg Phe Pro 
        355                 360                 365             


Val Pro Glu Leu Ser Asp Gln Glu Gly Asp Ser Ser Ser Glu Glu Asp 
    370                 375                 380                 


<210>  368
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  368

Ser Leu Val Ile Arg Asn Leu Gln Arg Val Ile Pro Ile Arg Arg Ala 
1               5                   10                  15      


Pro Leu Arg Ser Lys Ile Glu Ile Val Arg Arg Ile Leu Gly Val Gln 
            20                  25                  30          


Lys Phe Asp Leu Gly Ile Ile Cys Val Asp Asn Lys Asn Ile Gln His 
        35                  40                  45              


Ile Asn Arg Ile Tyr Arg Asp Arg Asn Val Pro Thr Asp Val Leu Ser 
    50                  55                  60                  


Phe Pro Phe His Glu His Leu Lys Ala Gly Glu Phe Pro Gln Pro Asp 
65                  70                  75                  80  


Phe Pro Asp Asp Tyr Asn Leu Gly Asp Ile Phe Leu Gly Val Glu Tyr 
                85                  90                  95      


Ile Phe His Gln Cys Lys Glu Asn Glu Asp Tyr Asn Asp Val Leu Thr 
            100                 105                 110         


Val Thr Ala Thr His Gly Leu Cys His Leu Leu Gly Phe Thr His Gly 
        115                 120                 125             


Thr Glu Ala Glu Trp Gln Gln Met Phe Gln Lys Glu Lys Ala Val Leu 
    130                 135                 140                 


Asp Glu Leu Gly Arg Arg Thr Gly Thr Arg Leu Gln Pro Leu Thr Arg 
145                 150                 155                 160 


Gly Leu Phe Gly Gly Ser 
                165     


<210>  369
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  369

Gln Glu Val Ile Ala Gly Leu Glu Arg Phe Thr Phe Ala Phe Glu Lys 
1               5                   10                  15      


Asp Val Glu Met Gln Lys Gly Thr Gly Leu Leu Pro Phe Gln Gly Met 
            20                  25                  30          


Asp Lys Ser Ala Ser Ala Val Cys Asn Phe Phe Thr Lys Gly Leu Cys 
        35                  40                  45              


Glu Lys Gly Lys Leu Cys Pro Phe Arg His Asp Arg Gly Glu Lys Met 
    50                  55                  60                  


Val Val Cys Lys His Trp Leu Arg Gly Leu Cys Lys Lys Gly Asp His 
65                  70                  75                  80  


Cys Lys Phe Leu His Gln Tyr Asp Leu Thr Arg Met Pro Glu Cys Tyr 
                85                  90                  95      


Phe Tyr Ser Lys Phe Gly Asp Cys Ser Asn Lys Glu Cys Ser Phe Leu 
            100                 105                 110         


His Val Lys Pro Ala Phe Lys Ser Gln Asp Cys Pro Trp Tyr Asp Gln 
        115                 120                 125             


Gly Phe Cys Lys Asp Gly Pro Leu Cys Lys Tyr Arg His Val Pro Arg 
    130                 135                 140                 


Ile Met Cys Leu Asn Tyr Leu Val Gly Phe Cys Pro Glu Gly Pro Lys 
145                 150                 155                 160 


Cys Gln Phe Ala Gln Lys Ile Arg Glu Phe Lys Leu Leu Pro Gly Ser 
                165                 170                 175     


Lys Ile 
        


<210>  370
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  370

Lys Leu Val Arg Lys Asn Ile Glu Lys Asp Asn Ala Gly Gln Val Thr 
1               5                   10                  15      


Leu Val Pro Glu Glu Pro Glu Asp Met Trp His Thr Tyr Asn Leu Val 
            20                  25                  30          


Gln Val Gly Asp Ser Leu Arg Ala Ser Thr Ile Arg Lys Val Gln Thr 
        35                  40                  45              


Glu Ser Ser Thr Gly Ser Val Gly Ser Asn Arg Val Arg Thr Thr Leu 
    50                  55                  60                  


Thr Leu Cys Val Glu Ala Ile Asp Phe Asp Ser Gln Ala Cys Gln Leu 
65                  70                  75                  80  


Arg Val Lys Gly Thr Asn Ile Gln Glu Asn Glu Tyr Val Lys Met Gly 
                85                  90                  95      


Ala Tyr His Thr Ile Glu Leu Glu Pro Asn Arg Gln Phe Thr Leu Ala 
            100                 105                 110         


Lys Lys Gln Trp Asp Ser Val Val Leu Glu Arg Ile Glu Gln Ala Cys 
        115                 120                 125             


Asp Pro Ala Trp Ser Ala Asp Val Ala Ala Val Val Met Gln Glu Gly 
    130                 135                 140                 


Leu Ala His Ile Cys Leu Val Thr Pro Ser Met Thr Leu Thr Arg Ala 
145                 150                 155                 160 


Lys Val Glu Val Asn Ile Pro Arg Lys Arg Lys Gly Asn Cys Ser Gln 
                165                 170                 175     


His Asp Arg Ala Leu Glu Arg Phe Tyr Glu Gln Val Val Gln Ala Ile 
            180                 185                 190         


Gln Arg His Ile His Phe Asp Val Val Lys Cys Ile Leu Val Ala Ser 
        195                 200                 205             


Pro Gly Phe Val Arg Glu Gln Phe Cys Asp Tyr Met Phe Gln Gln Ala 
    210                 215                 220                 


Val Lys Thr Asp Asn Lys Leu Leu Leu Glu Asn Arg Ser Lys Phe Leu 
225                 230                 235                 240 


Gln Val His Ala Ser Ser Gly His Lys Tyr Ser Leu Lys Glu Ala Leu 
                245                 250                 255     


Cys Asp Pro Thr Val Ala Ser Arg Leu Ser Asp Thr Lys Ala Ala Gly 
            260                 265                 270         


Glu Val Lys Ala Leu Asp Asp Phe Tyr Lys Met Leu Gln His Glu Pro 
        275                 280                 285             


Asp Arg Ala Phe Tyr Gly Leu Lys Gln Val Glu Lys Ala Asn Glu Ala 
    290                 295                 300                 


Met Ala Ile Asp Thr Leu Leu Ile Ser Asp Glu Leu Phe Arg His Gln 
305                 310                 315                 320 


Asp Val Ala Thr Arg Ser Arg Tyr Val Arg Leu Val Asp Ser Val Lys 
                325                 330                 335     


Glu Asn Ala Gly Thr Val Arg Ile Phe Ser Ser Leu His Val Ser Gly 
            340                 345                 350         


Glu Gln Leu Ser Gln Leu Thr Gly Val Ala Ala Ile Leu Arg Phe Pro 
        355                 360                 365             


Val Pro Glu Leu Ser Asp Gln Glu Gly Asp Ser Ser Ser Glu Glu Asp 
    370                 375                 380                 


<210>  371
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  371

Asp Pro Ala Trp Ser Ala Asp Val Ala Ala Val Val Met Gln Glu Gly 
1               5                   10                  15      


Leu Ala His Ile Cys Leu Val Thr Pro Ser Met Thr Leu Thr Arg Ala 
            20                  25                  30          


Lys Val Glu Val Asn Ile Pro Arg Lys Arg Lys Gly Asn Cys Ser Gln 
        35                  40                  45              


His Asp Arg Ala Leu Glu Arg Phe Tyr Glu Gln Val Val Gln Ala Ile 
    50                  55                  60                  


Gln Arg His Ile His Phe Asp Val Val Lys Cys Ile Leu Val Ala Ser 
65                  70                  75                  80  


Pro Gly Phe Val Arg Glu Gln Phe Cys Asp Tyr Met Phe Gln Gln Ala 
                85                  90                  95      


Val Lys Thr Asp Asn Lys Leu Leu Leu Glu Asn Arg Ser Lys Phe Leu 
            100                 105                 110         


Gln Val His Ala Ser Ser Gly His Lys Tyr Ser Leu Lys Glu Ala Leu 
        115                 120                 125             


Cys Asp Pro Thr Val Ala Ser Arg Leu Ser Asp Thr Lys Ala Ala Gly 
    130                 135                 140                 


Glu Val Lys Ala Leu Asp Asp Phe Tyr Lys Met Leu Gln His Glu Pro 
145                 150                 155                 160 


Asp Arg Ala Phe Tyr Gly Leu Lys Gln Val Glu Lys Ala Asn Glu Ala 
                165                 170                 175     


Met Ala Ile Asp Thr Leu Leu Ile Ser Asp Glu Leu Phe Arg His Gln 
            180                 185                 190         


Asp Val Ala Thr Arg Ser Arg Tyr Val Arg Leu Val Asp Ser Val Lys 
        195                 200                 205             


Glu Asn Ala Gly Thr Val Arg Ile Phe Ser Ser Leu His Val Ser Gly 
    210                 215                 220                 


Glu Gln Leu Ser Gln Leu Thr Gly Val Ala Ala Ile Leu Arg Phe Pro 
225                 230                 235                 240 


Val Pro Glu Leu Ser Asp Gln Glu Gly Asp Ser Ser Ser Glu Glu Asp 
                245                 250                 255     


<210>  372
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  372

Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro 
1               5                   10                  15      


Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro 
            20                  25                  30          


Pro Gly Val Arg Gly Asn Pro Val Leu Lys Phe Val Arg Asn Val Pro 
        35                  40                  45              


Trp Glu Phe Gly Asp Val Ile Pro Asp Tyr Val Leu Gly Gln Ser Thr 
    50                  55                  60                  


Cys Ala Leu Phe Leu Ser Leu Arg Tyr His Asn Leu His Pro Asp Tyr 
65                  70                  75                  80  


Ile His Gly Arg Leu Gln Ser Leu Gly Lys Asn Phe Ala Leu Arg Val 
                85                  90                  95      


Leu Leu Val Gln Val Asp Val Lys Asp Pro Gln Gln Ala Leu Lys Glu 
            100                 105                 110         


Leu Ala Lys Met Cys Ile Leu Ala Asp Cys Thr Leu Ile Leu Ala Trp 
        115                 120                 125             


Ser Pro Glu Glu Ala Gly Arg Tyr Leu Glu Thr Tyr Lys Ala Tyr Glu 
    130                 135                 140                 


Gln Lys Pro Ala Asp Leu Leu Met Glu Lys Leu Glu Gln Asp Phe Val 
145                 150                 155                 160 


Ser Arg Val Thr Glu Cys Leu Thr Thr Val Lys Ser Val Asn Lys Thr 
                165                 170                 175     


Asp Ser Gln Thr Leu Leu Thr Thr Phe Gly Ser Leu Glu Gln Leu Ile 
            180                 185                 190         


Ala Ala Ser Arg Glu Asp Leu Ala Leu Cys Pro Gly Leu Gly Pro Gln 
        195                 200                 205             


Lys 
    


<210>  373
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  373

Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


<210>  374
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  374

Gln Asp Asn Ser Arg Tyr Thr His Phe Leu Thr Gln His Tyr Asp Ala 
1               5                   10                  15      


Lys Pro Gln Gly Arg Asp Asp Arg Tyr Cys Glu Ser Ile Met Arg Arg 
            20                  25                  30          


Arg Gly Leu Thr Ser Pro Cys Lys Asp Ile Asn Thr Phe Ile His Gly 
        35                  40                  45              


Asn Lys Arg Ser Ile Lys Ala Ile Cys Glu Asn Lys Asn Gly Asn Pro 
    50                  55                  60                  


His Arg Glu Asn Leu Arg Ile Ser Lys Ser Ser Phe Gln Val Thr Thr 
65                  70                  75                  80  


Cys Lys Leu His Gly Gly Ser Pro Trp Pro Pro Cys Gln Tyr Arg Ala 
                85                  90                  95      


Thr Ala Gly Phe Arg Asn Val Val Val Ala Cys Glu Asn Gly Leu Pro 
            100                 105                 110         


Val His Leu Asp Gln Ser Ile Phe Arg Arg Pro 
        115                 120             


<210>  375
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  375

Gly Leu Gly Leu Val Gln Pro Ser Tyr Gly Gln Asp Gly Met Tyr Gln 
1               5                   10                  15      


Arg Phe Leu Arg Gln His Val His Pro Glu Glu Thr Gly Gly Ser Asp 
            20                  25                  30          


Arg Tyr Cys Asn Leu Met Met Gln Arg Arg Lys Met Thr Leu Tyr His 
        35                  40                  45              


Cys Lys Arg Phe Asn Thr Phe Ile His Glu Asp Ile Trp Asn Ile Arg 
    50                  55                  60                  


Ser Ile Cys Ser Thr Thr Asn Ile Gln Cys Lys Asn Gly Lys Met Asn 
65                  70                  75                  80  


Cys His Glu Gly Val Val Lys Val Thr Asp Cys Arg Asp Thr Gly Ser 
                85                  90                  95      


Ser Arg Ala Pro Asn Cys Arg Tyr Arg Ala Ile Ala Ser Thr Arg Arg 
            100                 105                 110         


Val Val Ile Ala Cys Glu Gly Asn Pro Gln Val Pro Val His Phe Asp 
        115                 120                 125             


Gly 
    


<210>  376
<211>  375
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  376

Xaa Ser Ala Val Asp Asn Ile Leu Leu Lys Leu Ala Lys Phe Lys Ile 
1               5                   10                  15      


Gly Phe Leu Arg Leu Gly Gln Ile Gln Lys Val His Pro Ala Ile Gln 
            20                  25                  30          


Gln Phe Thr Glu Gln Glu Ile Cys Arg Ser Lys Ser Ile Lys Ser Leu 
        35                  40                  45              


Ala Leu Leu Glu Glu Leu Tyr Asn Ser Gln Leu Ile Val Ala Thr Thr 
    50                  55                  60                  


Cys Met Gly Ile Asn His Pro Ile Phe Ser Arg Lys Ile Phe Asp Phe 
65                  70                  75                  80  


Cys Ile Val Asp Glu Ala Ser Gln Ile Ser Gln Pro Ile Cys Leu Gly 
                85                  90                  95      


Pro Leu Phe Phe Ser Arg Arg Phe Val Leu Val Gly Asp His Gln Gln 
            100                 105                 110         


Leu Pro Pro Leu Val Leu Asn Arg Glu Ala Arg Ala Leu Gly Met Ser 
        115                 120                 125             


Glu Ser Leu Phe Lys Arg Leu Glu Gln Asn Lys Ser Ala Val Val Gln 
    130                 135                 140                 


Leu Thr Val Gln Tyr Arg Met Asn Ser Lys Ile Met Ser Leu Ser Asn 
145                 150                 155                 160 


Lys Leu Thr Tyr Glu Gly Lys Leu Glu Cys Gly Ser Asp Lys Val Ala 
                165                 170                 175     


Asn Ala Val Ile Asn Leu Arg His Phe Lys Asp Val Lys Leu Glu Leu 
            180                 185                 190         


Glu Phe Tyr Ala Asp Tyr Ser Asp Asn Pro Trp Leu Met Gly Val Phe 
        195                 200                 205             


Glu Pro Asn Asn Pro Val Cys Phe Leu Asn Thr Asp Lys Val Pro Ala 
    210                 215                 220                 


Pro Glu Gln Val Glu Lys Gly Gly Val Ser Asn Val Thr Glu Ala Lys 
225                 230                 235                 240 


Leu Ile Val Phe Leu Thr Ser Ile Phe Val Lys Ala Gly Cys Ser Pro 
                245                 250                 255     


Ser Asp Ile Gly Ile Ile Ala Pro Tyr Arg Gln Gln Leu Lys Ile Ile 
            260                 265                 270         


Asn Asp Leu Leu Ala Arg Ser Ile Gly Met Val Glu Val Asn Thr Val 
        275                 280                 285             


Asp Lys Tyr Gln Gly Arg Asp Lys Ser Ile Val Leu Val Ser Phe Val 
    290                 295                 300                 


Arg Ser Asn Lys Asp Gly Thr Val Gly Glu Leu Leu Lys Asp Trp Arg 
305                 310                 315                 320 


Arg Leu Asn Val Ala Ile Thr Arg Ala Lys His Lys Leu Ile Leu Leu 
                325                 330                 335     


Gly Cys Val Pro Ser Leu Asn Cys Tyr Pro Pro Leu Glu Lys Leu Leu 
            340                 345                 350         


Asn His Leu Asn Ser Glu Lys Leu Ile Ser Phe Phe Phe Cys Ile Trp 
        355                 360                 365             


Ser His Leu Ile Ala Leu Leu 
    370                 375 


<210>  377
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  377

Met Ala Leu Arg Ser His Asp Arg Ser Thr Arg Pro Leu Tyr Ile Ser 
1               5                   10                  15      


Val Gly His Arg Met Ser Leu Glu Ala Ala Val Arg Leu Thr Cys Cys 
            20                  25                  30          


Cys Cys Arg Phe Arg Ile Pro Glu Pro Val Arg Gln Ala Asp Ile Cys 
        35                  40                  45              


Ser Arg Glu His Ile Arg Lys Ser Leu Gly Leu Pro Gly Pro Pro Thr 
    50                  55                  60                  


Pro Arg Ser Pro Lys Ala Gln Arg Pro Val Ala Cys Pro Lys Gly Asp 
65                  70                  75                  80  


Ser Gly Glu Ser Ser Ala Leu Cys 
                85              


<210>  378
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  378

Cys Tyr Thr Asn His Ala Leu Ser Tyr Asp Gln Ala Lys Arg Val Pro 
1               5                   10                  15      


Arg Trp Val Leu Glu His Ile Ser Lys Ser Lys Ile Met Gly Asp Ala 
            20                  25                  30          


Asp Arg Lys His Cys Lys Phe Lys Pro Asp Pro Asn Ile Pro Pro Thr 
        35                  40                  45              


Phe Ser Ala Phe Asn Glu Asp Tyr Val Gly Ser Gly Trp Ser Arg Gly 
    50                  55                  60                  


His Met Ala Pro Ala Gly Asn Asn Lys Phe Ser Ser Lys Ala Met Ala 
65                  70                  75                  80  


Glu Thr Phe Tyr Leu Ser Asn Ile Val Pro Gln Asp Phe Asp Asn Asn 
                85                  90                  95      


Ser Gly Tyr Trp Asn Arg Ile Glu Met Tyr Cys Arg Glu Leu Thr Glu 
            100                 105                 110         


Arg Phe Glu Asp Val Trp Val Val Ser Gly Pro Leu Thr Leu Pro Gln 
        115                 120                 125             


Thr Arg Gly Asp Gly Lys Lys Ile Val Ser Tyr Gln Val Ile Gly Glu 
    130                 135                 140                 


Asp Asn Val Ala Val Pro Ser His Leu Tyr Lys Val Ile Leu Ala Arg 
145                 150                 155                 160 


Arg Ser Ser Val Ser Thr Glu Pro Leu Ala Leu Gly Ala Phe Val Val 
                165                 170                 175     


Pro Asn Glu Ala Ile Gly Phe Gln Pro Gln Leu Thr Glu Phe Gln Val 
            180                 185                 190         


Ser Leu Gln Asp Leu Glu Lys Leu Ser Gly Leu Val Phe Phe Pro His 
        195                 200                 205             


Leu Asp Arg Thr 
    210         


<210>  379
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  379

Val Thr Val Ser Gln Met Thr Ser Val Leu Asn Gly Lys Thr Arg Arg 
1               5                   10                  15      


Phe Ala Asp Ile Gln Leu Gln His Gly Ala Leu Cys Phe Asn Ile Arg 
            20                  25                  30          


Tyr Gly Thr Thr Val Glu Glu Glu Lys Asn His Val Leu Glu Ile Ala 
        35                  40                  45              


Arg Gln Arg Ala Val Ala Gln Ala Trp Thr Lys Glu Gln Arg Arg Leu 
    50                  55                  60                  


Gln Glu Gly Glu Glu Gly Ile Arg Ala Trp Thr Glu Gly Glu Lys Gln 
65                  70                  75                  80  


Gln Leu Leu Ser Thr Gly Arg Val Gln Gly Tyr Asp Gly Tyr Phe Val 
                85                  90                  95      


Leu Ser Val Glu Gln Tyr Leu Glu Leu Ser Asp Ser Ala Asn Asn Ile 
            100                 105                 110         


His Phe Met Arg Gln Ser Glu Ile Gly Arg Arg 
        115                 120             


<210>  380
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  380

Thr Val Ser Gln Pro Thr Leu Leu Val Asn Gly Lys Thr Arg Arg Phe 
1               5                   10                  15      


Thr Asn Ile Glu Phe Gln Tyr Ser Thr Leu Leu Leu Ser Ile Arg Tyr 
            20                  25                  30          


Gly Leu Thr Pro Asp Thr Leu Asp Glu Glu Lys Ala Arg Val Leu Asp 
        35                  40                  45              


Gln Ala Arg Gln Arg Ala Leu Gly Thr Ala Trp Ala Lys Glu Gln Gln 
    50                  55                  60                  


Lys Ala Arg Asp Gly Arg Glu Gly Ser Arg Leu Trp Thr Glu Gly Glu 
65                  70                  75                  80  


Lys Gln Gln Leu Leu Ser Thr Gly Arg Val Gln Gly Tyr Glu Gly Tyr 
                85                  90                  95      


Tyr Val Leu Pro Val Glu Gln Tyr Pro Glu Leu Ala Asp Ser Ser Ser 
            100                 105                 110         


Asn Ile Gln Phe Leu Arg Gln Asn Glu Met Gly Lys Arg 
        115                 120                 125 


<210>  381
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RNAseK

<400>  381

Met Gly Trp Leu Arg Pro Gly Pro Arg Pro Leu Cys Pro Pro Ala Arg 
1               5                   10                  15      


Ala Ser Trp Ala Phe Ser His Arg Phe Pro Ser Pro Leu Ala Pro Arg 
            20                  25                  30          


Arg Ser Pro Thr Pro Phe Phe Met Ala Ser Leu Leu Cys Cys Gly Pro 
        35                  40                  45              


Lys Leu Ala Ala Cys Gly Ile Val Leu Ser Ala Trp Gly Val Ile Met 
    50                  55                  60                  


Leu Ile Met Leu Gly Ile Phe Phe Asn Val His Ser Ala Val Leu Ile 
65                  70                  75                  80  


Glu Asp Val Pro Phe Thr Glu Lys Asp Phe Glu Asn Gly Pro Gln Asn 
                85                  90                  95      


Ile Tyr Asn Leu Tyr Glu Gln Val Ser Tyr Asn Cys Phe Ile Ala Ala 
            100                 105                 110         


Gly Leu Tyr Leu Leu Leu Gly Gly Phe Ser Phe Cys Gln Val Arg Leu 
        115                 120                 125             


Asn Lys Arg Lys Glu Tyr Met Val Arg 
    130                 135         


<210>  382
<211>  1245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TALEN

<400>  382

Met Arg Ile Gly Lys Ser Ser Gly Trp Leu Asn Glu Ser Val Ser Leu 
1               5                   10                  15      


Glu Tyr Glu His Val Ser Pro Pro Thr Arg Pro Arg Asp Thr Arg Arg 
            20                  25                  30          


Arg Pro Arg Ala Ala Gly Asp Gly Gly Leu Ala His Leu His Arg Arg 
        35                  40                  45              


Leu Ala Val Gly Tyr Ala Glu Asp Thr Pro Arg Thr Glu Ala Arg Ser 
    50                  55                  60                  


Pro Ala Pro Arg Arg Pro Leu Pro Val Ala Pro Ala Ser Ala Pro Pro 
65                  70                  75                  80  


Ala Pro Ser Leu Val Pro Glu Pro Pro Met Pro Val Ser Leu Pro Ala 
                85                  90                  95      


Val Ser Ser Pro Arg Phe Ser Ala Gly Ser Ser Ala Ala Ile Thr Asp 
            100                 105                 110         


Pro Phe Pro Ser Leu Pro Pro Thr Pro Val Leu Tyr Ala Met Ala Arg 
        115                 120                 125             


Glu Leu Glu Ala Leu Ser Asp Ala Thr Trp Gln Pro Ala Val Pro Leu 
    130                 135                 140                 


Pro Ala Glu Pro Pro Thr Asp Ala Arg Arg Gly Asn Thr Val Phe Asp 
145                 150                 155                 160 


Glu Ala Ser Ala Ser Ser Pro Val Ile Ala Ser Ala Cys Pro Gln Ala 
                165                 170                 175     


Phe Ala Ser Pro Pro Arg Ala Pro Arg Ser Ala Arg Ala Arg Arg Ala 
            180                 185                 190         


Arg Thr Gly Gly Asp Ala Trp Pro Ala Pro Thr Phe Leu Ser Arg Pro 
        195                 200                 205             


Ser Ser Ser Arg Ile Gly Arg Asp Val Phe Gly Lys Leu Val Ala Leu 
    210                 215                 220                 


Gly Tyr Ser Arg Glu Gln Ile Arg Lys Leu Lys Gln Glu Ser Leu Ser 
225                 230                 235                 240 


Glu Ile Ala Lys Tyr His Thr Thr Leu Thr Gly Gln Gly Phe Thr His 
                245                 250                 255     


Ala Asp Ile Cys Arg Ile Ser Arg Arg Arg Gln Ser Leu Arg Val Val 
            260                 265                 270         


Ala Arg Asn Tyr Pro Glu Leu Ala Ala Ala Leu Pro Glu Leu Thr Arg 
        275                 280                 285             


Ala His Ile Val Asp Ile Ala Arg Gln Arg Ser Gly Asp Leu Ala Leu 
    290                 295                 300                 


Gln Ala Leu Leu Pro Val Ala Thr Ala Leu Thr Ala Ala Pro Leu Arg 
305                 310                 315                 320 


Leu Ser Ala Ser Gln Ile Ala Thr Val Ala Gln Tyr Gly Glu Arg Pro 
                325                 330                 335     


Ala Ile Gln Ala Leu Tyr Arg Leu Arg Arg Lys Leu Thr Arg Ala Pro 
            340                 345                 350         


Leu His Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Thr Gly 
        355                 360                 365             


Gly Lys Arg Ala Leu Glu Ala Val Cys Val Gln Leu Pro Val Leu Arg 
    370                 375                 380                 


Ala Ala Pro Tyr Arg Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser 
385                 390                 395                 400 


Asn Lys Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala His Leu Leu 
                405                 410                 415     


Asp Leu Leu Gly Ala Pro Tyr Val Leu Asp Thr Glu Gln Val Val Ala 
            420                 425                 430         


Ile Ala Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala Val Lys Ala 
        435                 440                 445             


Asp Leu Leu Asp Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr Glu Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Gln Ala Leu Glu Ala 
465                 470                 475                 480 


Val Lys Ala Asp Leu Leu Glu Leu Arg Gly Ala Pro Tyr Ala Leu Ser 
                485                 490                 495     


Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly Lys Gln Ala 
            500                 505                 510         


Leu Glu Ala Val Lys Ala His Leu Leu Asp Leu Arg Gly Val Pro Tyr 
        515                 520                 525             


Ala Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asn Gly Gly 
    530                 535                 540                 


Lys Gln Ala Leu Glu Ala Val Lys Ala Gln Leu Leu Asp Leu Arg Gly 
545                 550                 555                 560 


Ala Pro Tyr Ala Leu Ser Thr Ala Gln Val Val Ala Ile Ala Ser Asn 
                565                 570                 575     


Gly Gly Gly Lys Gln Ala Leu Glu Gly Ile Gly Glu Gln Leu Leu Lys 
            580                 585                 590         


Leu Arg Thr Ala Pro Tyr Gly Leu Ser Thr Glu Gln Val Val Ala Ile 
        595                 600                 605             


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Ala Val Gly Ala Gln 
    610                 615                 620                 


Leu Val Ala Leu Arg Ala Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val 
625                 630                 635                 640 


Val Ala Ile Ala Ser Asn Lys Gly Gly Lys Gln Ala Leu Glu Ala Val 
                645                 650                 655     


Lys Ala Gln Leu Leu Glu Leu Arg Gly Ala Pro Tyr Ala Leu Ser Thr 
            660                 665                 670         


Ala Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Asn Gln Ala Leu 
        675                 680                 685             


Glu Ala Val Gly Thr Gln Leu Val Ala Leu Arg Ala Ala Pro Tyr Ala 
    690                 695                 700                 


Leu Ser Thr Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
705                 710                 715                 720 


Gln Ala Leu Glu Ala Val Gly Ala Gln Leu Val Ala Leu Arg Ala Ala 
                725                 730                 735     


Pro Tyr Ala Leu Asn Thr Glu Gln Val Val Ala Ile Ala Ser Ser His 
            740                 745                 750         


Gly Gly Lys Gln Ala Leu Glu Ala Val Arg Ala Leu Phe Pro Asp Leu 
        755                 760                 765             


Arg Ala Ala Pro Tyr Ala Leu Ser Thr Ala Gln Leu Val Ala Ile Ala 
    770                 775                 780                 


Ser Asn Pro Gly Gly Lys Gln Ala Leu Glu Ala Val Arg Ala Leu Phe 
785                 790                 795                 800 


Arg Glu Leu Arg Ala Ala Pro Tyr Ala Leu Ser Thr Glu Gln Val Val 
                805                 810                 815     


Ala Ile Ala Ser Asn His Gly Gly Lys Gln Ala Leu Glu Ala Val Arg 
            820                 825                 830         


Ala Leu Phe Arg Gly Leu Arg Ala Ala Pro Tyr Gly Leu Ser Thr Ala 
        835                 840                 845             


Gln Val Val Ala Ile Ala Ser Ser Asn Gly Gly Lys Gln Ala Leu Glu 
    850                 855                 860                 


Ala Val Trp Ala Leu Leu Pro Val Leu Arg Ala Thr Pro Tyr Asp Leu 
865                 870                 875                 880 


Asn Thr Ala Gln Ile Val Ala Ile Ala Ser His Asp Gly Gly Lys Pro 
                885                 890                 895     


Ala Leu Glu Ala Val Trp Ala Lys Leu Pro Val Leu Arg Gly Ala Pro 
            900                 905                 910         


Tyr Ala Leu Ser Thr Ala Gln Val Val Ala Ile Ala Cys Ile Ser Gly 
        915                 920                 925             


Gln Gln Ala Leu Glu Ala Ile Glu Ala His Met Pro Thr Leu Arg Gln 
    930                 935                 940                 


Ala Ser His Ser Leu Ser Pro Glu Arg Val Ala Ala Ile Ala Cys Ile 
945                 950                 955                 960 


Gly Gly Arg Ser Ala Val Glu Ala Val Arg Gln Gly Leu Pro Val Lys 
                965                 970                 975     


Ala Ile Arg Arg Ile Arg Arg Glu Lys Ala Pro Val Ala Gly Pro Pro 
            980                 985                 990         


Pro Ala Ser Leu Gly Pro Thr Pro  Gln Glu Leu Val Ala  Val Leu His 
        995                 1000                 1005             


Phe Phe  Arg Ala His Gln Gln  Pro Arg Gln Ala Phe  Val Asp Ala 
    1010                 1015                 1020             


Leu Ala  Ala Phe Gln Ala Thr  Arg Pro Ala Leu Leu  Arg Leu Leu 
    1025                 1030                 1035             


Ser Ser  Val Gly Val Thr Glu  Ile Glu Ala Leu Gly  Gly Thr Ile 
    1040                 1045                 1050             


Pro Asp  Ala Thr Glu Arg Trp  Gln Arg Leu Leu Gly  Arg Leu Gly 
    1055                 1060                 1065             


Phe Arg  Pro Ala Thr Gly Ala  Ala Ala Pro Ser Pro  Asp Ser Leu 
    1070                 1075                 1080             


Gln Gly  Phe Ala Gln Ser Leu  Glu Arg Thr Leu Gly  Ser Pro Gly 
    1085                 1090                 1095             


Met Ala  Gly Gln Ser Ala Cys  Ser Pro His Arg Lys  Arg Pro Ala 
    1100                 1105                 1110             


Glu Thr  Ala Ile Ala Pro Arg  Ser Ile Arg Arg Ser  Pro Asn Asn 
    1115                 1120                 1125             


Ala Gly  Gln Pro Ser Glu Pro  Trp Pro Asp Gln Leu  Ala Trp Leu 
    1130                 1135                 1140             


Gln Arg  Arg Lys Arg Thr Ala  Arg Ser His Ile Arg  Ala Asp Ser 
    1145                 1150                 1155             


Ala Ala  Ser Val Pro Ala Asn  Leu His Leu Gly Thr  Arg Ala Gln 
    1160                 1165                 1170             


Phe Thr  Pro Asp Arg Leu Arg  Ala Glu Pro Gly Pro  Ile Met Gln 
    1175                 1180                 1185             


Ala His  Thr Ser Pro Ala Ser  Val Ser Phe Gly Ser  His Val Ala 
    1190                 1195                 1200             


Phe Glu  Pro Gly Leu Pro Asp  Pro Gly Thr Pro Thr  Ser Ala Asp 
    1205                 1210                 1215             


Leu Ala  Ser Phe Glu Ala Glu  Pro Phe Gly Val Gly  Pro Leu Asp 
    1220                 1225                 1230             


Phe His  Leu Asp Trp Leu Leu  Gln Ile Leu Glu Thr  
    1235                 1240                 1245 


<210>  383
<211>  1373
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TALEN

<400>  383

Met Asp Pro Ile Arg Ser Arg Thr Pro Ser Pro Ala Arg Glu Leu Leu 
1               5                   10                  15      


Pro Gly Pro Gln Pro Asp Arg Val Gln Pro Thr Ala Asp Arg Gly Gly 
            20                  25                  30          


Ala Pro Pro Ala Gly Gly Pro Leu Asp Gly Leu Pro Ala Arg Arg Thr 
        35                  40                  45              


Met Ser Arg Thr Arg Leu Pro Ser Pro Pro Ala Pro Ser Pro Ala Phe 
    50                  55                  60                  


Ser Ala Gly Ser Phe Ser Asp Leu Leu Arg Gln Phe Asp Pro Ser Leu 
65                  70                  75                  80  


Leu Asp Thr Ser Leu Leu Asp Ser Met Pro Ala Val Gly Thr Pro His 
                85                  90                  95      


Thr Ala Ala Ala Pro Ala Glu Cys Asp Glu Val Gln Ser Gly Leu Arg 
            100                 105                 110         


Ala Ala Asp Asp Pro Pro Pro Thr Val Arg Val Ala Val Thr Ala Ala 
        115                 120                 125             


Arg Pro Pro Arg Ala Lys Pro Ala Pro Arg Arg Arg Ala Ala Gln Pro 
    130                 135                 140                 


Ser Asp Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly Tyr 
145                 150                 155                 160 


Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Gly Ser Thr Val 
                165                 170                 175     


Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 
            180                 185                 190         


Ile Val Ala Leu Ser Arg His Pro Ala Ala Leu Gly Thr Val Ala Val 
        195                 200                 205             


Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Asp 
    210                 215                 220                 


Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 
225                 230                 235                 240 


Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 
                245                 250                 255     


Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 
            260                 265                 270         


Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
        275                 280                 285             


Leu Thr Pro Ala Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
    290                 295                 300                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
305                 310                 315                 320 


His Gly Leu Thr Pro Ala Gln Val Val Ala Ile Ala Ser His Asp Gly 
                325                 330                 335     


Gly Lys Gln Ala Leu Glu Thr Met Gln Arg Leu Leu Pro Val Leu Cys 
            340                 345                 350         


Gln Ala His Gly Leu Pro Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
        355                 360                 365             


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    370                 375                 380                 


Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
385                 390                 395                 400 


Ser His Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
                405                 410                 415     


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala 
            420                 425                 430         


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        435                 440                 445             


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val 
    450                 455                 460                 


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
465                 470                 475                 480 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp 
                485                 490                 495     


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Lys Gln Ala Leu Glu Thr 
            500                 505                 510         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        515                 520                 525             


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
    530                 535                 540                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Thr His Gly Leu 
545                 550                 555                 560 


Thr Pro Ala Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
                565                 570                 575     


Ala Leu Glu Thr Val Gln Gln Leu Leu Pro Val Leu Cys Gln Ala His 
            580                 585                 590         


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
        595                 600                 605             


Lys Gln Ala Leu Ala Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    610                 615                 620                 


Ala His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly 
625                 630                 635                 640 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                645                 650                 655     


Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
            660                 665                 670         


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        675                 680                 685             


Val Leu Cys Gln Ala His Gly Leu Thr Gln Val Gln Val Val Ala Ile 
    690                 695                 700                 


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
705                 710                 715                 720 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val 
                725                 730                 735     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            740                 745                 750         


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln 
        755                 760                 765             


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
    770                 775                 780                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Gln 
785                 790                 795                 800 


Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
                805                 810                 815     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            820                 825                 830         


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
        835                 840                 845             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    850                 855                 860                 


Gly Leu Thr Pro Ala Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
865                 870                 875                 880 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                885                 890                 895     


Asp His Gly Leu Thr Leu Ala Gln Val Val Ala Ile Ala Ser Asn Ile 
            900                 905                 910         


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
        915                 920                 925             


Cys Gln Ala His Gly Leu Thr Gln Asp Gln Val Val Ala Ile Ala Ser 
    930                 935                 940                 


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
945                 950                 955                 960 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
                965                 970                 975     


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
            980                 985                 990         


Leu Pro Val Leu Cys Gln Asp His  Gly Leu Thr Leu Asp  Gln Val Val 
        995                 1000                 1005             


Ala Ile  Ala Ser Asn Gly Gly  Lys Gln Ala Leu Glu  Thr Val Gln 
    1010                 1015                 1020             


Arg Leu  Leu Pro Val Leu Cys  Gln Asp His Gly Leu  Thr Pro Asp 
    1025                 1030                 1035             


Gln Val  Val Ala Ile Ala Ser  Asn Ser Gly Gly Lys  Gln Ala Leu 
    1040                 1045                 1050             


Glu Thr  Val Gln Arg Leu Leu  Pro Val Leu Cys Gln  Asp His Gly 
    1055                 1060                 1065             


Leu Thr  Pro Asn Gln Val Val  Ala Ile Ala Ser Asn  Gly Gly Lys 
    1070                 1075                 1080             


Gln Ala  Leu Glu Ser Ile Val  Ala Gln Leu Ser Arg  Pro Asp Pro 
    1085                 1090                 1095             


Ala Leu  Ala Ala Leu Thr Asn  Asp His Leu Val Ala  Leu Ala Cys 
    1100                 1105                 1110             


Leu Gly  Gly Arg Pro Ala Met  Asp Ala Val Lys Lys  Gly Leu Pro 
    1115                 1120                 1125             


His Ala  Pro Glu Leu Ile Arg  Arg Val Asn Arg Arg  Ile Gly Glu 
    1130                 1135                 1140             


Arg Thr  Ser His Arg Val Ala  Asp Tyr Ala Gln Val  Val Arg Val 
    1145                 1150                 1155             


Leu Glu  Phe Phe Gln Cys His  Ser His Pro Ala Tyr  Ala Phe Asp 
    1160                 1165                 1170             


Glu Ala  Met Thr Gln Phe Gly  Met Ser Arg Asn Gly  Leu Val Gln 
    1175                 1180                 1185             


Leu Phe  Arg Arg Val Gly Val  Thr Glu Leu Glu Ala  Arg Gly Gly 
    1190                 1195                 1200             


Thr Leu  Pro Pro Ala Ser Gln  Arg Trp Asp Arg Ile  Leu Gln Ala 
    1205                 1210                 1215             


Ser Gly  Met Lys Arg Ala Lys  Pro Ser Pro Thr Ser  Ala Gln Thr 
    1220                 1225                 1230             


Pro Asp  Gln Ala Ser Leu His  Ala Phe Ala Asp Ser  Leu Glu Arg 
    1235                 1240                 1245             


Asp Leu  Asp Ala Pro Ser Pro  Met His Glu Gly Asp  Gln Thr Gly 
    1250                 1255                 1260             


Ala Ser  Ser Arg Lys Arg Ser  Arg Ser Asp Arg Ala  Val Thr Gly 
    1265                 1270                 1275             


Pro Ser  Ala Gln His Ser Phe  Glu Val Arg Val Pro  Glu Gln Arg 
    1280                 1285                 1290             


Asp Ala  Leu His Leu Pro Leu  Ser Trp Arg Val Lys  Arg Pro Arg 
    1295                 1300                 1305             


Thr Arg  Ile Gly Gly Gly Leu  Pro Asp Pro Gly Thr  Pro Ile Ala 
    1310                 1315                 1320             


Ala Asp  Leu Ala Ala Ser Ser  Thr Val Met Trp Glu  Gln Asp Ala 
    1325                 1330                 1335             


Ala Pro  Phe Ala Gly Ala Ala  Asp Asp Phe Pro Ala  Phe Asn Glu 
    1340                 1345                 1350             


Glu Glu  Leu Ala Trp Leu Met  Glu Leu Leu Pro Gln  Ser Gly Ser 
    1355                 1360                 1365             


Val Gly  Gly Thr Ile 
    1370             


<210>  384
<211>  1978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ZNF638

<400>  384

Met Ser Arg Pro Arg Phe Asn Pro Arg Gly Asp Phe Pro Leu Gln Arg 
1               5                   10                  15      


Pro Arg Ala Pro Asn Pro Ser Gly Met Arg Pro Pro Gly Pro Phe Met 
            20                  25                  30          


Arg Pro Gly Ser Met Gly Leu Pro Arg Phe Tyr Pro Ala Gly Arg Ala 
        35                  40                  45              


Arg Gly Ile Pro His Arg Phe Ala Gly His Glu Ser Tyr Gln Asn Met 
    50                  55                  60                  


Gly Pro Gln Arg Met Asn Val Gln Val Thr Gln His Arg Thr Asp Pro 
65                  70                  75                  80  


Arg Leu Thr Lys Glu Lys Leu Asp Phe His Glu Ala Gln Gln Lys Lys 
                85                  90                  95      


Gly Lys Pro His Gly Ser Arg Trp Asp Asp Glu Pro His Ile Ser Ala 
            100                 105                 110         


Ser Val Ala Val Lys Gln Ser Ser Val Thr Gln Val Thr Glu Gln Ser 
        115                 120                 125             


Pro Lys Val Gln Ser Arg Tyr Thr Lys Glu Ser Ala Ser Ser Ile Leu 
    130                 135                 140                 


Ala Ser Phe Gly Leu Ser Asn Glu Asp Leu Glu Glu Leu Ser Arg Tyr 
145                 150                 155                 160 


Pro Asp Glu Gln Leu Thr Pro Glu Asn Met Pro Leu Ile Leu Arg Asp 
                165                 170                 175     


Ile Arg Met Arg Lys Met Gly Arg Arg Leu Pro Asn Leu Pro Ser Gln 
            180                 185                 190         


Ser Arg Asn Lys Glu Thr Leu Gly Ser Glu Ala Val Ser Ser Asn Val 
        195                 200                 205             


Ile Asp Tyr Gly His Ala Ser Lys Tyr Gly Tyr Thr Glu Asp Pro Leu 
    210                 215                 220                 


Glu Val Arg Ile Tyr Asp Pro Glu Ile Pro Thr Asp Glu Val Glu Asn 
225                 230                 235                 240 


Glu Phe Gln Ser Gln Gln Asn Ile Ser Ala Ser Val Pro Asn Pro Asn 
                245                 250                 255     


Val Ile Cys Asn Ser Met Phe Pro Val Glu Asp Val Phe Arg Gln Met 
            260                 265                 270         


Asp Phe Pro Gly Glu Ser Ser Asn Asn Arg Ser Phe Phe Ser Val Glu 
        275                 280                 285             


Ser Gly Thr Lys Met Ser Gly Leu His Ile Ser Gly Gly Gln Ser Val 
    290                 295                 300                 


Leu Glu Pro Ile Lys Ser Val Asn Gln Ser Ile Asn Gln Thr Val Ser 
305                 310                 315                 320 


Gln Thr Met Ser Gln Ser Leu Ile Pro Pro Ser Met Asn Gln Gln Pro 
                325                 330                 335     


Phe Ser Ser Glu Leu Ile Ser Ser Val Ser Gln Gln Glu Arg Ile Pro 
            340                 345                 350         


His Glu Pro Val Ile Asn Ser Ser Asn Val His Val Gly Ser Arg Gly 
        355                 360                 365             


Ser Lys Lys Asn Tyr Gln Ser Gln Ala Asp Ile Pro Ile Arg Ser Pro 
    370                 375                 380                 


Phe Gly Ile Val Lys Ala Ser Trp Leu Pro Lys Phe Ser His Ala Asp 
385                 390                 395                 400 


Ala Gln Lys Met Lys Arg Leu Pro Thr Pro Ser Met Met Asn Asp Tyr 
                405                 410                 415     


Tyr Ala Ala Ser Pro Arg Ile Phe Pro His Leu Cys Ser Leu Cys Asn 
            420                 425                 430         


Val Glu Cys Ser His Leu Lys Asp Trp Ile Gln His Gln Asn Thr Ser 
        435                 440                 445             


Thr His Ile Glu Ser Cys Arg Gln Leu Arg Gln Gln Tyr Pro Asp Trp 
    450                 455                 460                 


Asn Pro Glu Ile Leu Pro Ser Arg Arg Asn Glu Gly Asn Arg Lys Glu 
465                 470                 475                 480 


Asn Glu Thr Pro Arg Arg Arg Ser His Ser Pro Ser Pro Arg Arg Ser 
                485                 490                 495     


Arg Arg Ser Ser Ser Ser His Arg Phe Arg Arg Ser Arg Ser Pro Met 
            500                 505                 510         


His Tyr Met Tyr Arg Pro Arg Ser Arg Ser Pro Arg Ile Cys His Arg 
        515                 520                 525             


Phe Ile Ser Arg Tyr Arg Ser Arg Ser Arg Ser Arg Ser Pro Tyr Arg 
    530                 535                 540                 


Ile Arg Asn Pro Phe Arg Gly Ser Pro Lys Cys Phe Arg Ser Val Ser 
545                 550                 555                 560 


Pro Glu Arg Met Ser Arg Arg Ser Val Arg Ser Ser Asp Arg Lys Lys 
                565                 570                 575     


Ala Leu Glu Asp Val Val Gln Arg Ser Gly His Gly Thr Glu Phe Asn 
            580                 585                 590         


Lys Gln Lys His Leu Glu Ala Ala Asp Lys Gly His Ser Pro Ala Gln 
        595                 600                 605             


Lys Pro Lys Thr Ser Ser Gly Thr Lys Pro Ser Val Lys Pro Thr Ser 
    610                 615                 620                 


Ala Thr Lys Ser Asp Ser Asn Leu Gly Gly His Ser Ile Arg Cys Lys 
625                 630                 635                 640 


Ser Lys Asn Leu Glu Asp Asp Thr Leu Ser Glu Cys Lys Gln Val Ser 
                645                 650                 655     


Asp Lys Ala Val Ser Leu Gln Arg Lys Leu Arg Lys Glu Gln Ser Leu 
            660                 665                 670         


His Tyr Gly Ser Val Leu Leu Ile Thr Glu Leu Pro Glu Asp Gly Cys 
        675                 680                 685             


Thr Glu Glu Asp Val Arg Lys Leu Phe Gln Pro Phe Gly Lys Val Asn 
    690                 695                 700                 


Asp Val Leu Ile Val Pro Tyr Arg Lys Glu Ala Tyr Leu Glu Met Glu 
705                 710                 715                 720 


Phe Lys Glu Ala Ile Thr Ala Ile Met Lys Tyr Ile Glu Thr Thr Pro 
                725                 730                 735     


Leu Thr Ile Lys Gly Lys Ser Val Lys Ile Cys Val Pro Gly Lys Lys 
            740                 745                 750         


Lys Ala Gln Asn Lys Glu Val Lys Lys Lys Thr Leu Glu Ser Lys Lys 
        755                 760                 765             


Val Ser Ala Ser Thr Leu Lys Arg Asp Ala Asp Ala Ser Lys Ala Val 
    770                 775                 780                 


Glu Ile Val Thr Ser Thr Ser Ala Ala Lys Thr Gly Gln Ala Lys Ala 
785                 790                 795                 800 


Ser Val Ala Lys Val Asn Lys Ser Thr Gly Lys Ser Ala Ser Ser Val 
                805                 810                 815     


Lys Ser Val Val Thr Val Ala Val Lys Gly Asn Lys Ala Ser Ile Lys 
            820                 825                 830         


Thr Ala Lys Ser Gly Gly Lys Lys Ser Leu Glu Ala Lys Lys Thr Gly 
        835                 840                 845             


Asn Val Lys Asn Lys Asp Ser Asn Lys Pro Val Thr Ile Pro Glu Asn 
    850                 855                 860                 


Ser Glu Ile Lys Thr Ser Ile Glu Val Lys Ala Thr Glu Asn Cys Ala 
865                 870                 875                 880 


Lys Glu Ala Ile Ser Asp Ala Ala Leu Glu Ala Thr Glu Asn Glu Pro 
                885                 890                 895     


Leu Asn Lys Glu Thr Glu Glu Met Cys Val Met Leu Val Ser Asn Leu 
            900                 905                 910         


Pro Asn Lys Gly Tyr Ser Val Glu Glu Val Tyr Asp Leu Ala Lys Pro 
        915                 920                 925             


Phe Gly Gly Leu Lys Asp Ile Leu Ile Leu Ser Ser His Lys Lys Ala 
    930                 935                 940                 


Tyr Ile Glu Ile Asn Arg Lys Ala Ala Glu Ser Met Val Lys Phe Tyr 
945                 950                 955                 960 


Thr Cys Phe Pro Val Leu Met Asp Gly Asn Gln Leu Ser Ile Ser Met 
                965                 970                 975     


Ala Pro Glu Asn Met Asn Ile Lys Asp Glu Glu Ala Ile Phe Ile Thr 
            980                 985                 990         


Leu Val Lys Glu Asn Asp Pro Glu  Ala Asn Ile Asp Thr  Ile Tyr Asp 
        995                 1000                 1005             


Arg Phe  Val His Leu Asp Asn  Leu Pro Glu Asp Gly  Leu Gln Cys 
    1010                 1015                 1020             


Val Leu  Cys Val Gly Leu Gln  Phe Gly Lys Val Asp  His His Val 
    1025                 1030                 1035             


Phe Ile  Ser Asn Arg Asn Lys  Ala Ile Leu Gln Leu  Asp Ser Pro 
    1040                 1045                 1050             


Glu Ser  Ala Gln Ser Met Tyr  Ser Phe Leu Lys Gln  Asn Pro Gln 
    1055                 1060                 1065             


Asn Ile  Gly Asp His Met Leu  Thr Cys Ser Leu Ser  Pro Lys Ile 
    1070                 1075                 1080             


Asp Leu  Pro Glu Val Gln Ile  Glu His Asp Pro Glu  Leu Glu Lys 
    1085                 1090                 1095             


Glu Ser  Pro Gly Leu Lys Asn  Ser Pro Ile Asp Glu  Ser Glu Val 
    1100                 1105                 1110             


Gln Thr  Ala Thr Asp Ser Pro  Ser Val Lys Pro Asn  Glu Leu Glu 
    1115                 1120                 1125             


Glu Glu  Ser Thr Pro Ser Ile  Gln Thr Glu Thr Leu  Val Gln Gln 
    1130                 1135                 1140             


Glu Glu  Pro Cys Glu Glu Glu  Ala Glu Lys Ala Thr  Cys Asp Ser 
    1145                 1150                 1155             


Asp Phe  Ala Val Glu Thr Leu  Glu Leu Glu Thr Gln  Gly Glu Glu 
    1160                 1165                 1170             


Val Lys  Glu Glu Ile Pro Leu  Val Ala Ser Ala Ser  Val Ser Ile 
    1175                 1180                 1185             


Glu Gln  Phe Thr Glu Asn Ala  Glu Glu Cys Ala Leu  Asn Gln Gln 
    1190                 1195                 1200             


Met Phe  Asn Ser Asp Leu Glu  Lys Lys Gly Ala Glu  Ile Ile Asn 
    1205                 1210                 1215             


Pro Lys  Thr Ala Leu Leu Pro  Ser Asp Ser Val Phe  Ala Glu Glu 
    1220                 1225                 1230             


Arg Asn  Leu Lys Gly Ile Leu  Glu Glu Ser Pro Ser  Glu Ala Glu 
    1235                 1240                 1245             


Asp Phe  Ile Ser Gly Ile Thr  Gln Thr Met Val Glu  Ala Val Ala 
    1250                 1255                 1260             


Glu Val  Glu Lys Asn Glu Thr  Val Ser Glu Ile Leu  Pro Ser Thr 
    1265                 1270                 1275             


Cys Ile  Val Thr Leu Val Pro  Gly Ile Pro Thr Gly  Asp Glu Lys 
    1280                 1285                 1290             


Thr Val  Asp Lys Lys Asn Ile  Ser Glu Lys Lys Gly  Asn Met Asp 
    1295                 1300                 1305             


Glu Lys  Glu Glu Lys Glu Phe  Asn Thr Lys Glu Thr  Arg Met Asp 
    1310                 1315                 1320             


Leu Gln  Ile Gly Thr Glu Lys  Ala Glu Lys Asn Glu  Gly Arg Met 
    1325                 1330                 1335             


Asp Ala  Glu Lys Val Glu Lys  Met Ala Ala Met Lys  Glu Lys Pro 
    1340                 1345                 1350             


Ala Glu  Asn Thr Leu Phe Lys  Ala Tyr Pro Asn Lys  Gly Val Gly 
    1355                 1360                 1365             


Gln Ala  Asn Lys Pro Asp Glu  Thr Ser Lys Thr Ser  Ile Leu Ala 
    1370                 1375                 1380             


Val Ser  Asp Val Ser Ser Ser  Lys Pro Ser Ile Lys  Ala Val Ile 
    1385                 1390                 1395             


Val Ser  Ser Pro Lys Ala Lys  Ala Thr Val Ser Lys  Thr Glu Asn 
    1400                 1405                 1410             


Gln Lys  Ser Phe Pro Lys Ser  Val Pro Arg Asp Gln  Ile Asn Ala 
    1415                 1420                 1425             


Glu Lys  Lys Leu Ser Ala Lys  Glu Phe Gly Leu Leu  Lys Pro Thr 
    1430                 1435                 1440             


Ser Ala  Arg Ser Gly Leu Ala  Glu Ser Ser Ser Lys  Phe Lys Pro 
    1445                 1450                 1455             


Thr Gln  Ser Ser Leu Thr Arg  Gly Gly Ser Gly Arg  Ile Ser Ala 
    1460                 1465                 1470             


Leu Gln  Gly Lys Leu Ser Lys  Leu Asp Tyr Arg Asp  Ile Thr Lys 
    1475                 1480                 1485             


Gln Ser  Gln Glu Thr Glu Ala  Arg Pro Ser Ile Met  Lys Arg Asp 
    1490                 1495                 1500             


Asp Ser  Asn Asn Lys Thr Leu  Ala Glu Gln Asn Thr  Lys Asn Pro 
    1505                 1510                 1515             


Lys Ser  Thr Thr Gly Arg Ser  Ser Lys Ser Lys Glu  Glu Pro Leu 
    1520                 1525                 1530             


Phe Pro  Phe Asn Leu Asp Glu  Phe Val Thr Val Asp  Glu Val Ile 
    1535                 1540                 1545             


Glu Glu  Val Asn Pro Ser Gln  Ala Lys Gln Asn Pro  Leu Lys Gly 
    1550                 1555                 1560             


Lys Arg  Lys Glu Thr Leu Lys  Asn Val Pro Phe Ser  Glu Leu Asn 
    1565                 1570                 1575             


Leu Lys  Lys Lys Lys Gly Lys  Thr Ser Thr Pro Arg  Gly Val Glu 
    1580                 1585                 1590             


Gly Glu  Leu Ser Phe Val Thr  Leu Asp Glu Ile Gly  Glu Glu Glu 
    1595                 1600                 1605             


Asp Ala  Ala Ala His Leu Ala  Gln Ala Leu Val Thr  Val Asp Glu 
    1610                 1615                 1620             


Val Ile  Asp Glu Glu Glu Leu  Asn Met Glu Glu Met  Val Lys Asn 
    1625                 1630                 1635             


Ser Asn  Ser Leu Phe Thr Leu  Asp Glu Leu Ile Asp  Gln Asp Asp 
    1640                 1645                 1650             


Cys Ile  Ser His Ser Glu Pro  Lys Asp Val Thr Val  Leu Ser Val 
    1655                 1660                 1665             


Ala Glu  Glu Gln Asp Leu Leu  Lys Gln Glu Arg Leu  Val Thr Val 
    1670                 1675                 1680             


Asp Glu  Ile Gly Glu Val Glu  Glu Leu Pro Leu Asn  Glu Ser Ala 
    1685                 1690                 1695             


Asp Ile  Thr Phe Ala Thr Leu  Asn Thr Lys Gly Asn  Glu Gly Asp 
    1700                 1705                 1710             


Thr Val  Arg Asp Ser Ile Gly  Phe Ile Ser Ser Gln  Val Pro Glu 
    1715                 1720                 1725             


Asp Pro  Ser Thr Leu Val Thr  Val Asp Glu Ile Gln  Asp Asp Ser 
    1730                 1735                 1740             


Ser Asp  Leu His Leu Val Thr  Leu Asp Glu Val Thr  Glu Glu Asp 
    1745                 1750                 1755             


Glu Asp  Ser Leu Ala Asp Phe  Asn Asn Leu Lys Glu  Glu Leu Asn 
    1760                 1765                 1770             


Phe Val  Thr Val Asp Glu Val  Gly Glu Glu Glu Asp  Gly Asp Asn 
    1775                 1780                 1785             


Asp Leu  Lys Val Glu Leu Ala  Gln Ser Lys Asn Asp  His Pro Thr 
    1790                 1795                 1800             


Asp Lys  Lys Gly Asn Arg Lys  Lys Arg Ala Val Asp  Thr Lys Lys 
    1805                 1810                 1815             


Thr Lys  Leu Glu Ser Leu Ser  Gln Val Gly Pro Val  Asn Glu Asn 
    1820                 1825                 1830             


Val Met  Glu Glu Asp Leu Lys  Thr Met Ile Glu Arg  His Leu Thr 
    1835                 1840                 1845             


Ala Lys  Thr Pro Thr Lys Arg  Val Arg Ile Gly Lys  Thr Leu Pro 
    1850                 1855                 1860             


Ser Glu  Lys Ala Val Val Thr  Glu Pro Ala Lys Gly  Glu Glu Ala 
    1865                 1870                 1875             


Phe Gln  Met Ser Glu Val Asp  Glu Glu Ser Gly Leu  Lys Asp Ser 
    1880                 1885                 1890             


Glu Pro  Glu Arg Lys Arg Lys  Lys Thr Glu Asp Ser  Ser Ser Gly 
    1895                 1900                 1905             


Lys Ser  Val Ala Ser Asp Val  Pro Glu Glu Leu Asp  Phe Leu Val 
    1910                 1915                 1920             


Pro Lys  Ala Gly Phe Phe Cys  Pro Ile Cys Ser Leu  Phe Tyr Ser 
    1925                 1930                 1935             


Gly Glu  Lys Ala Met Thr Asn  His Cys Lys Ser Thr  Arg His Lys 
    1940                 1945                 1950             


Gln Asn  Thr Glu Lys Phe Met  Ala Lys Gln Arg Lys  Glu Lys Glu 
    1955                 1960                 1965             


Gln Asn  Glu Ala Glu Glu Arg  Ser Ser Arg 
    1970                 1975             


<210>  385
<211>  938
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  tCAG promoter

<400>  385
ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga       60

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat      120

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc      180

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct      240

attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc      300

ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg      360

gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg      420

cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg      480

aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg agtcgctgcg      540

acgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc cccggctctg      600

actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc cgggctgtaa      660

ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa gccttgaggg      720

gctccgggag ggccctttgt gcggggggag cggctcgggg ctgtccgcgg ggggacggct      780

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta      840

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc      900

tggttattgt gctgtctcat cattttggca aagaattg                              938


<210>  386

<400>  386
000

<210>  387

<400>  387
000

<210>  388

<400>  388
000

<210>  389

<400>  389
000

<210>  390

<400>  390
000

<210>  391

<400>  391
000

<210>  392

<400>  392
000

<210>  393
<211>  28
<212>  DNA
<213>  Leptotrichia shahii

<400>  393
ccaccccaat atcgaagggg actaaaac                                          28


<210>  394
<211>  36
<212>  DNA
<213>  Leptotrichia wadei

<400>  394
gatttagact accccaaaaa cgaaggggac taaaac                                 36


<210>  395
<211>  36
<212>  DNA
<213>  Listeria seeligeri

<400>  395
gtaagagact acctctatat gaaagaggac taaaac                                 36


<210>  396
<211>  35
<212>  DNA
<213>  Lachnospiraceae bacterium MA2020

<400>  396
gtattgagaa aagccagata tagttggcaa tagac                                  35


<210>  397
<211>  35
<212>  DNA
<213>  Lachnospiraceae bacterium NK4A179

<400>  397
gttgatgaga agagcccaag atagagggca ataac                                  35


<210>  398
<211>  35
<212>  DNA
<213>  Clostridium aminophilum DSM 10710

<400>  398
gtctattgcc ctctatatcg ggctgttctc caaac                                  35


<210>  399
<211>  36
<212>  DNA
<213>  Carnobacterium gallinarum DSM 4847

<400>  399
attaaagact acctctaaat gtaagaggac tataac                                 36


<210>  400
<211>  36
<212>  DNA
<213>  Carnobacterium gallinarum DSM 4847

<400>  400
aatataaact acctctaaat gtaagaggac tataac                                 36


<210>  401
<211>  36
<212>  DNA
<213>  Paludibacter propionicigenes WB4

<400>  401
cttgtggatt atcccaaaat tgaagggaac tacaac                                 36


<210>  402
<211>  36
<212>  DNA
<213>  Listeria weihenstephanensis FSL R9-0317

<400>  402
gatttagagt acctcaaaat agaagaggtc taaaac                                 36


<210>  403
<211>  36
<212>  DNA
<213>  Listeriaceae bacterium FSL M6-0635

<400>  403
gatttagagt acctcaaaac aaaagaggac taaaac                                 36


<210>  404
<211>  36
<212>  DNA
<213>  Leptotrichia wadei F0279

<400>  404
gatatagata accccaaaaa cgaagggatc taaaac                                 36


<210>  405
<211>  36
<212>  DNA
<213>  Rhodobacter capsulatus SB 1003

<400>  405
gcctcacatc accgccaaga cgacggcgga ctgaac                                 36


<210>  406
<211>  36
<212>  DNA
<213>  Rhodobacter capsulatus R121

<400>  406
gcctcacatc accgccaaga cgacggcgga ctgaac                                 36


<210>  407
<211>  36
<212>  DNA
<213>  Rhodobacter capsulatus DE442

<400>  407
gcctcacatc accgccaaga cgacggcgga ctgaac                                 36


<210>  408
<211>  1389
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cas13a

<400>  408

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Arg Asp Lys 
1               5                   10                  15      


Lys Asp Phe Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Lys Tyr Ile Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Ile Leu Lys Glu Phe Thr Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Lys Glu Gly Ile Ile Arg Ile Glu Asn Asn 
                85                  90                  95      


Asp Asp Phe Leu Glu Thr Glu Glu Val Val Leu Tyr Ile Glu Ala Tyr 
            100                 105                 110         


Gly Lys Ser Glu Lys Leu Lys Ala Leu Gly Ile Thr Lys Lys Lys Ile 
        115                 120                 125             


Ile Asp Glu Ala Ile Arg Gln Gly Ile Thr Lys Asp Asp Lys Lys Ile 
    130                 135                 140                 


Glu Ile Lys Arg Gln Glu Asn Glu Glu Glu Ile Glu Ile Asp Ile Arg 
145                 150                 155                 160 


Asp Glu Tyr Thr Asn Lys Thr Leu Asn Asp Cys Ser Ile Ile Leu Arg 
                165                 170                 175     


Ile Ile Glu Asn Asp Glu Leu Glu Thr Lys Lys Ser Ile Tyr Glu Ile 
            180                 185                 190         


Phe Lys Asn Ile Asn Met Ser Leu Tyr Lys Ile Ile Glu Lys Ile Ile 
        195                 200                 205             


Glu Asn Glu Thr Glu Lys Val Phe Glu Asn Arg Tyr Tyr Glu Glu His 
    210                 215                 220                 


Leu Arg Glu Lys Leu Leu Lys Asp Asp Lys Ile Asp Val Ile Leu Thr 
225                 230                 235                 240 


Asn Phe Met Glu Ile Arg Glu Lys Ile Lys Ser Asn Leu Glu Ile Leu 
                245                 250                 255     


Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser 
            260                 265                 270         


Lys Asn Lys Lys Met Leu Val Glu Lys Ile Leu Asn Ile Asn Val Asp 
        275                 280                 285             


Leu Thr Val Glu Asp Ile Ala Asp Phe Val Ile Lys Glu Leu Glu Phe 
    290                 295                 300                 


Trp Asn Ile Thr Lys Arg Ile Glu Lys Val Lys Lys Val Asn Asn Glu 
305                 310                 315                 320 


Phe Leu Glu Lys Arg Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu 
                325                 330                 335     


Leu Asp Lys His Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp 
            340                 345                 350         


Lys Ile Val Lys Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys 
        355                 360                 365             


Glu Lys Ile Glu Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Ile 
    370                 375                 380                 


Lys Lys Leu Glu Lys Glu Leu Lys Lys Gly Asn Cys Asp Thr Glu Ile 
385                 390                 395                 400 


Phe Gly Ile Phe Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys 
                405                 410                 415     


Phe Ser Lys Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr 
            420                 425                 430         


Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Val Asn Glu Gln Lys 
        435                 440                 445             


Val Arg Leu Lys Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn 
    450                 455                 460                 


Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr 
465                 470                 475                 480 


Leu Glu His Ile Met Tyr Leu Gly Lys Leu Arg His Asn Asp Ile Asp 
                485                 490                 495     


Met Thr Thr Val Asn Thr Asp Asp Phe Ser Arg Leu His Ala Lys Glu 
            500                 505                 510         


Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu 
        515                 520                 525             


Leu Asn Lys Ile Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile 
    530                 535                 540                 


Asp Phe Phe Gly Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys 
545                 550                 555                 560 


Ile Leu Asn Ser Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp 
                565                 570                 575     


Asn Lys Asn Asn Ile Thr Asn Asn Phe Ile Arg Lys Phe Thr Lys Ile 
            580                 585                 590         


Gly Thr Asn Glu Arg Asn Arg Ile Leu His Ala Ile Ser Lys Glu Arg 
        595                 600                 605             


Asp Leu Gln Gly Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile 
    610                 615                 620                 


Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu 
625                 630                 635                 640 


Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn Asp 
                645                 650                 655     


Ile Lys Ile Ser Glu Glu Asn Asn Asn Asp Ile Lys Tyr Leu Pro Ser 
            660                 665                 670         


Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn Asn Pro 
        675                 680                 685             


Lys Asn Glu Pro Phe Asp Thr Ile Glu Thr Glu Lys Ile Val Leu Asn 
    690                 695                 700                 


Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu 
705                 710                 715                 720 


Asp Asp Leu Glu Glu Asn Glu Ser Lys Asn Ile Phe Leu Gln Glu Leu 
                725                 730                 735     


Lys Lys Thr Leu Gly Asn Ile Asp Glu Ile Asp Glu Asn Ile Ile Glu 
            740                 745                 750         


Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys 
        755                 760                 765             


Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu Cys Tyr Ile Gly Tyr 
    770                 775                 780                 


Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp Phe Ser Asp Phe Lys Met 
785                 790                 795                 800 


Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Asp Ile Asn Asp Asn Lys 
                805                 810                 815     


Thr Tyr Glu Arg Ile Thr Val Lys Thr Ser Asp Lys Thr Ile Val Ile 
            820                 825                 830         


Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser 
        835                 840                 845             


Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val 
    850                 855                 860                 


Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile Asp Ile Leu Asp Glu 
865                 870                 875                 880 


Ile Met Gln Leu Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp 
                885                 890                 895     


Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys 
            900                 905                 910         


Asp Phe Asp Asp Phe Lys Ile Gln Thr Lys Lys Glu Ile Phe Asn Asn 
        915                 920                 925             


Tyr Tyr Glu Asp Ile Lys Asn Asn Ile Leu Thr Glu Phe Lys Asp Asp 
    930                 935                 940                 


Ile Asn Gly Cys Asp Val Leu Glu Lys Lys Leu Glu Lys Ile Val Ile 
945                 950                 955                 960 


Phe Asp Asp Glu Thr Lys Phe Glu Ile Asp Lys Lys Ser Asn Ile Leu 
                965                 970                 975     


Gln Asp Glu Gln Arg Lys Leu Ser Asn Ile Asn Lys Lys Asp Leu Lys 
            980                 985                 990         


Lys Lys Val Asp Gln Tyr Ile Lys  Asp Lys Asp Gln Glu  Ile Lys Ser 
        995                 1000                 1005             


Lys Ile  Leu Cys Arg Ile Ile  Phe Asn Ser Asp Phe  Leu Lys Lys 
    1010                 1015                 1020             


Tyr Lys  Lys Glu Ile Asp Asn  Leu Ile Glu Asp Met  Glu Ser Glu 
    1025                 1030                 1035             


Asn Glu  Asn Lys Phe Gln Glu  Ile Tyr Tyr Pro Lys  Glu Arg Lys 
    1040                 1045                 1050             


Asn Glu  Leu Tyr Ile Tyr Lys  Lys Asn Leu Phe Leu  Asn Ile Gly 
    1055                 1060                 1065             


Asn Pro  Asn Phe Asp Lys Ile  Tyr Gly Leu Ile Ser  Asn Asp Ile 
    1070                 1075                 1080             


Lys Met  Ala Asp Ala Lys Phe  Leu Phe Asn Ile Asp  Gly Lys Asn 
    1085                 1090                 1095             


Ile Arg  Lys Asn Lys Ile Ser  Glu Ile Asp Ala Ile  Leu Lys Asn 
    1100                 1105                 1110             


Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Lys Glu Tyr  Lys Glu Lys 
    1115                 1120                 1125             


Tyr Ile  Lys Lys Leu Lys Glu  Asn Asp Asp Phe Phe  Ala Lys Asn 
    1130                 1135                 1140             


Ile Gln  Asn Lys Asn Tyr Lys  Ser Phe Glu Lys Asp  Tyr Asn Arg 
    1145                 1150                 1155             


Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu Val Glu  Phe Asn Tyr 
    1160                 1165                 1170             


Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp Ile Asn  Trp Lys Leu 
    1175                 1180                 1185             


Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp Met His  Tyr Ile Val 
    1190                 1195                 1200             


Asn Gly  Leu Arg Glu Leu Gly  Ile Ile Lys Leu Ser  Gly Tyr Asn 
    1205                 1210                 1215             


Thr Gly  Ile Ser Arg Ala Tyr  Pro Lys Arg Asn Gly  Ser Asp Gly 
    1220                 1225                 1230             


Phe Tyr  Thr Thr Thr Ala Tyr  Tyr Lys Phe Phe Asp  Glu Glu Ser 
    1235                 1240                 1245             


Tyr Lys  Lys Phe Glu Lys Ile  Cys Tyr Gly Phe Gly  Ile Asp Leu 
    1250                 1255                 1260             


Ser Glu  Asn Ser Glu Ile Asn  Lys Pro Glu Asn Glu  Ser Ile Arg 
    1265                 1270                 1275             


Asn Tyr  Ile Ser His Phe Tyr  Ile Val Arg Asn Pro  Phe Ala Asp 
    1280                 1285                 1290             


Tyr Ser  Ile Ala Glu Gln Ile  Asp Arg Val Ser Asn  Leu Leu Ser 
    1295                 1300                 1305             


Tyr Ser  Thr Arg Tyr Asn Asn  Ser Thr Tyr Ala Ser  Val Phe Glu 
    1310                 1315                 1320             


Val Phe  Lys Lys Asp Val Asn  Leu Asp Tyr Asp Glu  Leu Lys Lys 
    1325                 1330                 1335             


Lys Phe  Lys Leu Ile Gly Asn  Asn Asp Ile Leu Glu  Arg Leu Met 
    1340                 1345                 1350             


Lys Pro  Lys Lys Val Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser 
    1355                 1360                 1365             


Asp Tyr  Ile Lys Asn Leu Ile  Ile Glu Leu Leu Thr  Lys Ile Glu 
    1370                 1375                 1380             


Asn Thr  Asn Asp Thr Leu 
    1385                 


<210>  409
<211>  1221
<212>  PRT
<213>  Bergeyella zoohelcum ATCC 43767

<400>  409

Met Glu Asn Lys Thr Ser Leu Gly Asn Asn Ile Tyr Tyr Asn Pro Phe 
1               5                   10                  15      


Lys Pro Gln Asp Lys Ser Tyr Phe Ala Gly Tyr Phe Asn Ala Ala Met 
            20                  25                  30          


Glu Asn Thr Asp Ser Val Phe Arg Glu Leu Gly Lys Arg Leu Lys Gly 
        35                  40                  45              


Lys Glu Tyr Thr Ser Glu Asn Phe Phe Asp Ala Ile Phe Lys Glu Asn 
    50                  55                  60                  


Ile Ser Leu Val Glu Tyr Glu Arg Tyr Val Lys Leu Leu Ser Asp Tyr 
65                  70                  75                  80  


Phe Pro Met Ala Arg Leu Leu Asp Lys Lys Glu Val Pro Ile Lys Glu 
                85                  90                  95      


Arg Lys Glu Asn Phe Lys Lys Asn Phe Lys Gly Ile Ile Lys Ala Val 
            100                 105                 110         


Arg Asp Leu Arg Asn Phe Tyr Thr His Lys Glu His Gly Glu Val Glu 
        115                 120                 125             


Ile Thr Asp Glu Ile Phe Gly Val Leu Asp Glu Met Leu Lys Ser Thr 
    130                 135                 140                 


Val Leu Thr Val Lys Lys Lys Lys Val Lys Thr Asp Lys Thr Lys Glu 
145                 150                 155                 160 


Ile Leu Lys Lys Ser Ile Glu Lys Gln Leu Asp Ile Leu Cys Gln Lys 
                165                 170                 175     


Lys Leu Glu Tyr Leu Arg Asp Thr Ala Arg Lys Ile Glu Glu Lys Arg 
            180                 185                 190         


Arg Asn Gln Arg Glu Arg Gly Glu Lys Glu Leu Val Ala Pro Phe Lys 
        195                 200                 205             


Tyr Ser Asp Lys Arg Asp Asp Leu Ile Ala Ala Ile Tyr Asn Asp Ala 
    210                 215                 220                 


Phe Asp Val Tyr Ile Asp Lys Lys Lys Asp Ser Leu Lys Glu Ser Ser 
225                 230                 235                 240 


Lys Ala Lys Tyr Asn Thr Lys Ser Asp Pro Gln Gln Glu Glu Gly Asp 
                245                 250                 255     


Leu Lys Ile Pro Ile Ser Lys Asn Gly Val Val Phe Leu Leu Ser Leu 
            260                 265                 270         


Phe Leu Thr Lys Gln Glu Ile His Ala Phe Lys Ser Lys Ile Ala Gly 
        275                 280                 285             


Phe Lys Ala Thr Val Ile Asp Glu Ala Thr Val Ser Glu Ala Thr Val 
    290                 295                 300                 


Ser His Gly Lys Asn Ser Ile Cys Phe Met Ala Thr His Glu Ile Phe 
305                 310                 315                 320 


Ser His Leu Ala Tyr Lys Lys Leu Lys Arg Lys Val Arg Thr Ala Glu 
                325                 330                 335     


Ile Asn Tyr Gly Glu Ala Glu Asn Ala Glu Gln Leu Ser Val Tyr Ala 
            340                 345                 350         


Lys Glu Thr Leu Met Met Gln Met Leu Asp Glu Leu Ser Lys Val Pro 
        355                 360                 365             


Asp Val Val Tyr Gln Asn Leu Ser Glu Asp Val Gln Lys Thr Phe Ile 
    370                 375                 380                 


Glu Asp Trp Asn Glu Tyr Leu Lys Glu Asn Asn Gly Asp Val Gly Thr 
385                 390                 395                 400 


Met Glu Glu Glu Gln Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu 
                405                 410                 415     


Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Gln 
            420                 425                 430         


Phe Pro Thr Leu Arg Phe Gln Val His Leu Gly Asn Tyr Leu His Asp 
        435                 440                 445             


Ser Arg Pro Lys Glu Asn Leu Ile Ser Asp Arg Arg Ile Lys Glu Lys 
    450                 455                 460                 


Ile Thr Val Phe Gly Arg Leu Ser Glu Leu Glu His Lys Lys Ala Leu 
465                 470                 475                 480 


Phe Ile Lys Asn Thr Glu Thr Asn Glu Asp Arg Glu His Tyr Trp Glu 
                485                 490                 495     


Ile Phe Pro Asn Pro Asn Tyr Asp Phe Pro Lys Glu Asn Ile Ser Val 
            500                 505                 510         


Asn Asp Lys Asp Phe Pro Ile Ala Gly Ser Ile Leu Asp Arg Glu Lys 
        515                 520                 525             


Gln Pro Val Ala Gly Lys Ile Gly Ile Lys Val Lys Leu Leu Asn Gln 
    530                 535                 540                 


Gln Tyr Val Ser Glu Val Asp Lys Ala Val Lys Ala His Gln Leu Lys 
545                 550                 555                 560 


Gln Arg Lys Ala Ser Lys Pro Ser Ile Gln Asn Ile Ile Glu Glu Ile 
                565                 570                 575     


Val Pro Ile Asn Glu Ser Asn Pro Lys Glu Ala Ile Val Phe Gly Gly 
            580                 585                 590         


Gln Pro Thr Ala Tyr Leu Ser Met Asn Asp Ile His Ser Ile Leu Tyr 
        595                 600                 605             


Glu Phe Phe Asp Lys Trp Glu Lys Lys Lys Glu Lys Leu Glu Lys Lys 
    610                 615                 620                 


Gly Glu Lys Glu Leu Arg Lys Glu Ile Gly Lys Glu Leu Glu Lys Lys 
625                 630                 635                 640 


Ile Val Gly Lys Ile Gln Ala Gln Ile Gln Gln Ile Ile Asp Lys Asp 
                645                 650                 655     


Thr Asn Ala Lys Ile Leu Lys Pro Tyr Gln Asp Gly Asn Ser Thr Ala 
            660                 665                 670         


Ile Asp Lys Glu Lys Leu Ile Lys Asp Leu Lys Gln Glu Gln Asn Ile 
        675                 680                 685             


Leu Gln Lys Leu Lys Asp Glu Gln Thr Val Arg Glu Lys Glu Tyr Asn 
    690                 695                 700                 


Asp Phe Ile Ala Tyr Gln Asp Lys Asn Arg Glu Ile Asn Lys Val Arg 
705                 710                 715                 720 


Asp Arg Asn His Lys Gln Tyr Leu Lys Asp Asn Leu Lys Arg Lys Tyr 
                725                 730                 735     


Pro Glu Ala Pro Ala Arg Lys Glu Val Leu Tyr Tyr Arg Glu Lys Gly 
            740                 745                 750         


Lys Val Ala Val Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Thr 
        755                 760                 765             


Asp Phe Lys Asn Glu Trp Lys Gly Glu Gln His Ser Leu Leu Gln Lys 
    770                 775                 780                 


Ser Leu Ala Tyr Tyr Glu Gln Cys Lys Glu Glu Leu Lys Asn Leu Leu 
785                 790                 795                 800 


Pro Glu Lys Val Phe Gln His Leu Pro Phe Lys Leu Gly Gly Tyr Phe 
                805                 810                 815     


Gln Gln Lys Tyr Leu Tyr Gln Phe Tyr Thr Cys Tyr Leu Asp Lys Arg 
            820                 825                 830         


Leu Glu Tyr Ile Ser Gly Leu Val Gln Gln Ala Glu Asn Phe Lys Ser 
        835                 840                 845             


Glu Asn Lys Val Phe Lys Lys Val Glu Asn Glu Cys Phe Lys Phe Leu 
    850                 855                 860                 


Lys Lys Gln Asn Tyr Thr His Lys Glu Leu Asp Ala Arg Val Gln Ser 
865                 870                 875                 880 


Ile Leu Gly Tyr Pro Ile Phe Leu Glu Arg Gly Phe Met Asp Glu Lys 
                885                 890                 895     


Pro Thr Ile Ile Lys Gly Lys Thr Phe Lys Gly Asn Glu Ala Leu Phe 
            900                 905                 910         


Ala Asp Trp Phe Arg Tyr Tyr Lys Glu Tyr Gln Asn Phe Gln Thr Phe 
        915                 920                 925             


Tyr Asp Thr Glu Asn Tyr Pro Leu Val Glu Leu Glu Lys Lys Gln Ala 
    930                 935                 940                 


Asp Arg Lys Arg Lys Thr Lys Ile Tyr Gln Gln Lys Lys Asn Asp Val 
945                 950                 955                 960 


Phe Thr Leu Leu Met Ala Lys His Ile Phe Lys Ser Val Phe Lys Gln 
                965                 970                 975     


Asp Ser Ile Asp Gln Phe Ser Leu Glu Asp Leu Tyr Gln Ser Arg Glu 
            980                 985                 990         


Glu Arg Leu Gly Asn Gln Glu Arg  Ala Arg Gln Thr Gly  Glu Arg Asn 
        995                 1000                 1005             


Thr Asn  Tyr Ile Trp Asn Lys  Thr Val Asp Leu Lys  Leu Cys Asp 
    1010                 1015                 1020             


Gly Lys  Ile Thr Val Glu Asn  Val Lys Leu Lys Asn  Val Gly Asp 
    1025                 1030                 1035             


Phe Ile  Lys Tyr Glu Tyr Asp  Gln Arg Val Gln Ala  Phe Leu Lys 
    1040                 1045                 1050             


Tyr Glu  Glu Asn Ile Glu Trp  Gln Ala Phe Leu Ile  Lys Glu Ser 
    1055                 1060                 1065             


Lys Glu  Glu Glu Asn Tyr Pro  Tyr Val Val Glu Arg  Glu Ile Glu 
    1070                 1075                 1080             


Gln Tyr  Glu Lys Val Arg Arg  Glu Glu Leu Leu Lys  Glu Val His 
    1085                 1090                 1095             


Leu Ile  Glu Glu Tyr Ile Leu  Glu Lys Val Lys Asp  Lys Glu Ile 
    1100                 1105                 1110             


Leu Lys  Lys Gly Asp Asn Gln  Asn Phe Lys Tyr Tyr  Ile Leu Asn 
    1115                 1120                 1125             


Gly Leu  Leu Lys Gln Leu Lys  Asn Glu Asp Val Glu  Ser Tyr Lys 
    1130                 1135                 1140             


Val Phe  Asn Leu Asn Thr Glu  Pro Glu Asp Val Asn  Ile Asn Gln 
    1145                 1150                 1155             


Leu Lys  Gln Glu Ala Thr Asp  Leu Glu Gln Lys Ala  Phe Val Leu 
    1160                 1165                 1170             


Thr Tyr  Ile Arg Asn Lys Phe  Ala His Asn Gln Leu  Pro Lys Lys 
    1175                 1180                 1185             


Glu Phe  Trp Asp Tyr Cys Gln  Glu Lys Tyr Gly Lys  Glu Lys Thr 
    1190                 1195                 1200             


Tyr Ala  Glu Tyr Phe Ala Glu  Val Phe Lys Lys Glu  Lys Glu Ala 
    1205                 1210                 1215             


Leu Ile  Lys 
    1220     


<210>  410
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  410

Gly Gly Ser 
1           


<210>  411
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  411

Val Asp Thr Ala Asn Gly Ser 
1               5           


<210>  412
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  412

Val Asp Thr Gly Asn Gly Ser 
1               5           


<210>  413
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  413

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  414
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  414

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  415
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  415

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  416
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  416

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  417
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  417

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10  


<210>  418
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  418

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  419
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  419

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys 
            20  


<210>  420
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  420

Ala Pro Ala Pro Ala Pro Ala Pro 
1               5               


<210>  421
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  421

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10          


<210>  422
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  422

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro 
        


<210>  423
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  423

Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys 
1               5                   10  


<210>  424
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  424

Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser 
1               5                   10  


<210>  425
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  425

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys 
            20  


<210>  426
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  426

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  427
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  427

Arg Gln Thr Ser Pro Asp Pro Cys Pro Gln Leu Pro Leu Val Pro Arg 
1               5                   10                  15      


<210>  428
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  428

Val Asp Thr Gly Asn Trp Phe 
1               5           


<210>  429
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  429

Val Asp Thr Ala Asn Gly Ser Val Asp Thr Gly Asn Gly Ser 
1               5                   10                  


<210>  430
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  430

Ala Arg Asn Val Glu Glu Arg Leu Cys Leu 
1               5                   10  


<210>  431
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  431

Ala Ile Glu Leu Asn Pro Ser Asn Ala 
1               5                   


<210>  432
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  432

Ile Cys Gly Ser Arg Asn Leu 
1               5           


<210>  433
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  433

Val Leu Ala Thr Asp Met Ser Lys His 
1               5                   


<210>  434
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  434

Phe Leu Arg Glu Leu Pro Glu Pro 
1               5               


<210>  435
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  435

Leu Ile Pro Lys Asp Gln Tyr Tyr Cys 
1               5                   


<210>  436
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FLAG Tag

<400>  436

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  437
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SV40 NLS Tag

<400>  437

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  438
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  438

Gly Lys Lys Arg Lys Arg Ser Arg Lys 
1               5                   


<210>  439
<211>  7
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  439

Gly Lys Lys Arg Ser Lys Val 
1               5           


<210>  440
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  440

Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
1               5                   10                  15      


Lys Pro 
        


<210>  441
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  441

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  442
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  442

Lys Arg Ser Ala Glu Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu 
1               5                   10                  15      


Arg 
    


<210>  443
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  443

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Leu Asp Lys 
            


<210>  444
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF - frame 3

<400>  444

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  445
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  14PUF - frame 3

<400>  445

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Ile Met Glu 
        195                 200                 205             


Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu 
    210                 215                 220                 


Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln 
225                 230                 235                 240 


Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu 
                245                 250                 255     


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            260                 265                 270         


Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn 
        275                 280                 285             


Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn 
    290                 295                 300                 


Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp 
305                 310                 315                 320 


Gln Asn Gly Ser Tyr Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro 
                325                 330                 335     


Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala 
            340                 345                 350         


Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu 
        355                 360                 365             


His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln 
    370                 375                 380                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln 
385                 390                 395                 400 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                405                 410                 415     


Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
            420                 425                 430         


Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His 
    450                 455                 460                 


Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg 
465                 470                 475                 480 


Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly 
                485                 490                 495     


Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr 
            500                 505                 510         


Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile 
        515                 520                 525             


Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr 
    530                 535                 540                 


Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn 
545                 550                 555                 560 


Gly Val Asp Leu Gly 
                565 


<210>  446
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  14PUF - frame 3

<400>  446

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu 
                245                 250                 255     


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            260                 265                 270         


Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn 
        275                 280                 285             


Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu 
    290                 295                 300                 


Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln 
305                 310                 315                 320 


Met Tyr Gly Ser Tyr Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser 
                325                 330                 335     


Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys 
            340                 345                 350         


Cys Val Lys Asp Gln Asn Gly Ser Tyr Val Val Glu Lys Cys Ile Glu 
        355                 360                 365             


Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly 
    370                 375                 380                 


Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Asn Arg Val Ile Gln 
385                 390                 395                 400 


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
                405                 410                 415     


Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
            420                 425                 430         


Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His 
    450                 455                 460                 


Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg 
465                 470                 475                 480 


Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly 
                485                 490                 495     


Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr 
            500                 505                 510         


Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile 
        515                 520                 525             


Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr 
    530                 535                 540                 


Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn 
545                 550                 555                 560 


Gly Val Asp Leu Gly 
                565 


<210>  447
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  15PUF - frame 3

<400>  447

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Ile Met Glu 
        195                 200                 205             


Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu 
    210                 215                 220                 


Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln 
225                 230                 235                 240 


Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg 
                245                 250                 255     


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            260                 265                 270         


Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser 
        275                 280                 285             


Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn 
    290                 295                 300                 


Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp 
305                 310                 315                 320 


Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro 
                325                 330                 335     


Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala 
            340                 345                 350         


Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu 
        355                 360                 365             


His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln 
    370                 375                 380                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu 
385                 390                 395                 400 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                405                 410                 415     


Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn 
            420                 425                 430         


Asn Val Val Gln Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala 
        435                 440                 445             


Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser His 
    450                 455                 460                 


Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His 
465                 470                 475                 480 


Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu 
                485                 490                 495     


Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn 
            500                 505                 510         


Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val 
        515                 520                 525             


Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu 
    530                 535                 540                 


Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met 
545                 550                 555                 560 


Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile 
                565                 570                 575     


Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile 
            580                 585                 590         


Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
        595                 600                 605             


<210>  448
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  15PUF - frame 3

<400>  448

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Tyr Val Val Arg 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser His Ile Met Glu Phe 
        275                 280                 285             


Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg 
    290                 295                 300                 


Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala 
305                 310                 315                 320 


Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys 
                325                 330                 335     


Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg 
            340                 345                 350         


Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr 
        355                 360                 365             


Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu 
    370                 375                 380                 


Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln 
385                 390                 395                 400 


Asn Gly Ser Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln 
                405                 410                 415     


Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu 
            420                 425                 430         


Ser Thr His Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His 
        435                 440                 445             


Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His 
    450                 455                 460                 


Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His 
465                 470                 475                 480 


Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu 
                485                 490                 495     


Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn 
            500                 505                 510         


Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val 
        515                 520                 525             


Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu 
    530                 535                 540                 


Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met 
545                 550                 555                 560 


Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile 
                565                 570                 575     


Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile 
            580                 585                 590         


Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
        595                 600                 605             


<210>  449
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUF - frame 3

<400>  449

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Ile Met Glu 
        195                 200                 205             


Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu 
    210                 215                 220                 


Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln 
225                 230                 235                 240 


Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln 
                245                 250                 255     


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            260                 265                 270         


Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser 
        275                 280                 285             


Tyr Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn 
    290                 295                 300                 


Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp 
305                 310                 315                 320 


Gln Asn Gly Ser Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro 
                325                 330                 335     


Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala 
            340                 345                 350         


Leu Ser Thr His Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu 
        355                 360                 365             


His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln 
    370                 375                 380                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg 
385                 390                 395                 400 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                405                 410                 415     


Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser 
            420                 425                 430         


Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala 
        435                 440                 445             


Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala 
    450                 455                 460                 


Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys 
465                 470                 475                 480 


Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys 
                485                 490                 495     


Ile Arg Pro His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr 
            500                 505                 510         


Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
        515                 520                 525             


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
    530                 535                 540                 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
545                 550                 555                 560 


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
                565                 570                 575     


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
            580                 585                 590         


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
        595                 600                 605             


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
    610                 615                 620                 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
625                 630                 635                 640 


Val Asp Leu Gly 
                


<210>  450
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUF - frame 3

<400>  450

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


His Ile Met Glu Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln 
                245                 250                 255     


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            260                 265                 270         


Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser 
        275                 280                 285             


Tyr Val Ile Arg Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu 
    290                 295                 300                 


Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln 
305                 310                 315                 320 


Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser 
                325                 330                 335     


Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys 
            340                 345                 350         


Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu 
        355                 360                 365             


Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly 
    370                 375                 380                 


Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Arg 
385                 390                 395                 400 


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
                405                 410                 415     


Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
            420                 425                 430         


Tyr Val Ile Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His 
    450                 455                 460                 


Lys Phe Ala Asn Asn Val Val Gln Lys Cys Val Thr His Ala Ser Arg 
465                 470                 475                 480 


Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly 
                485                 490                 495     


Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr 
            500                 505                 510         


Val Val Arg Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile 
        515                 520                 525             


Val Met His Lys Ile Arg Pro Asn Val Leu Val Leu Ser Gln His Lys 
    530                 535                 540                 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
545                 550                 555                 560 


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
                565                 570                 575     


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
            580                 585                 590         


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
        595                 600                 605             


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
    610                 615                 620                 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
625                 630                 635                 640 


Val Asp Leu Gly 
                


<210>  451
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUF - frame 3

<400>  451

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Arg Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu Leu 
                325                 330                 335     


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
            340                 345                 350         


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
        355                 360                 365             


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
    370                 375                 380                 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
385                 390                 395                 400 


Tyr Gly Ser Tyr Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser Asp 
                405                 410                 415     


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
            420                 425                 430         


Val Lys Asp Gln Asn Gly Ser Tyr Val Val Glu Lys Cys Ile Glu Cys 
        435                 440                 445             


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
    450                 455                 460                 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Asn Arg Val Ile Gln Arg 
465                 470                 475                 480 


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
                485                 490                 495     


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr 
            500                 505                 510         


Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
        515                 520                 525             


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
    530                 535                 540                 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
545                 550                 555                 560 


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
                565                 570                 575     


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
            580                 585                 590         


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
        595                 600                 605             


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
    610                 615                 620                 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
625                 630                 635                 640 


Val Asp Leu Gly 
                


<210>  452
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  8PUF nucleic acid sequence

<400>  452
ggacgaagcc gactcttgga agacttcaga aacaatcggt atccgaacct tcagctgaga       60

gaaattgctg gtcacatcat ggaattttct caagatcaac atggaagccg gtttattgaa      120

cttaaactcg aacgagccac cccggccgaa aggcaattgg tgttcaatga aattcttcag      180

gccgcatacc aactcatggt tgatgttttt gggaactatg ttattcaaaa gttttttgag      240

ttcgggtcac tggagcaaaa gttggcattg gcagagcgaa tccggggcca tgttctgagc      300

ctcgctctcc aaatgtacgg tagttatgtc attcgcaaag cactcgagtt cataccatca      360

gatcaacaga atgagatggt gcgggagctg gatgggcatg ttttgaaatg cgtgaaagac      420

caaaacggta gctacgtagt tgagaaatgc atcgaatgcg tccaaccaca gtctctccaa      480

tttattatag atgcatttaa gggtcaggtt ttcgcgcttt ctacgcaccc gtatgggaac      540

cgagtgattc agagaatctt ggagcactgc ctgccggatc agacactccc tatcttggag      600

gaattgcacc agcataccga acaattggtg caagatcaat acggttcata tgttattcgg      660

cacgttcttg agcatggaag gccagaggac aagtcaaaga tcgtcgctga gattagaggt      720

aacgtattgg tgctctcaca acacaaattt gcatctaatg tggtggagaa atgtgttact      780

catgcttcta gaacggaaag ggcagttctc atagacgaag tttgcacaat gaatgatggt      840

cctcatagcg cactttatac catgatgaag gaccagtatg caaactatgt cgtccagaaa      900

atgatcgatg tggcggagcc cggtcaacgg aaaatcgtga tgcacaaaat ccgacctcac      960

attgctacac tcagaaaata cacgtatgga aaacatattc tggctaagct ggagaaatat     1020

tacatgaaga atggagtgga tctgggg                                         1047


<210>  453
<211>  8
<212>  RNA
<213>  Homo sapiens

<400>  453
ugcugcug                                                                 8


<210>  454
<211>  14
<212>  RNA
<213>  Homo sapiens

<400>  454
ugcugcugcu gcug                                                         14


<210>  455
<211>  15
<212>  RNA
<213>  Homo sapiens

<400>  455
ugcugcugcu gcugc                                                        15


<210>  456
<211>  16
<212>  RNA
<213>  Homo sapiens

<400>  456
ugcugcugcu gcugcu                                                       16


<210>  457
<211>  26
<212>  RNA
<213>  Homo sapiens

<400>  457
agcagcagca gcagcagcag cagcag                                            26


<210>  458
<211>  26
<212>  RNA
<213>  Homo sapiens

<400>  458
gcagcagcag cagcagcagc agcagc                                            26


<210>  459
<211>  26
<212>  RNA
<213>  Homo sapiens

<400>  459
cagcagcagc agcagcagca gcagca                                            26


<210>  460
<211>  1686
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  8PUF-E17 fusion protein insert

<400>  460
atggactata aagatgacga tgataaaccc aaaaagaaac gcaaggtggg acgaagccga       60

ctcttggaag acttcagaaa caatcggtat ccgaaccttc agctgagaga aattgctggt      120

cacatcatgg aattttctca agatcaacat ggaagccggt ttattgaact taaactcgaa      180

cgagccaccc cggccgaaag gcaattggtg ttcaatgaaa ttcttcaggc cgcataccaa      240

ctcatggttg atgtttttgg gaactatgtt attcaaaagt tttttgagtt cgggtcactg      300

gagcaaaagt tggcattggc agagcgaatc cggggccatg ttctgagcct cgctctccaa      360

atgtacggta gttatgtcat tcgcaaagca ctcgagttca taccatcaga tcaacagaat      420

gagatggtgc gggagctgga tgggcatgtt ttgaaatgcg tgaaagacca aaacggtagc      480

tacgtagttg agaaatgcat cgaatgcgtc caaccacagt ctctccaatt tattatagat      540

gcatttaagg gtcaggtttt cgcgctttct acgcacccgt atgggaaccg agtgattcag      600

agaatcttgg agcactgcct gccggatcag acactcccta tcttggagga attgcaccag      660

cataccgaac aattggtgca agatcaatac ggttcatatg ttattcggca cgttcttgag      720

catggaaggc cagaggacaa gtcaaagatc gtcgctgaga ttagaggtaa cgtattggtg      780

ctctcacaac acaaatttgc atctaatgtg gtggagaaat gtgttactca tgcttctaga      840

acggaaaggg cagttctcat agacgaagtt tgcacaatga atgatggtcc tcatagcgca      900

ctttatacca tgatgaagga ccagtatgca aactatgtcg tccagaaaat gatcgatgtg      960

gcggagcccg gtcaacggaa aatcgtgatg cacaaaatcc gacctcacat tgctacactc     1020

agaaaataca cgtatggaaa acatattctg gctaagctgg agaaatatta catgaagaat     1080

ggagtggatc tgggggtgga tactgccaat ggcagcggtg gtggcacccc taaggctccc     1140

aacctggagc ctccactccc agaagaggaa aaggagggca gcgacctgag accagtggtc     1200

atcgatggga gcaacgtggc catgagccat gggaacaagg aggtcttctc ctgccggggc     1260

atcctgctgg cagtgaactg gtttctggag cggggccaca cagacatcac agtgtttgtg     1320

ccatcctgga ggaaggagca gcctcggccc gacgtgccca tcacagacca gcacatcctg     1380

cgggaactgg agaagaagaa gatcctggtg ttcacaccat cacgacgcgt gggtggcaag     1440

cgggtggtgt gctatgacga cagattcatt gtgaagctgg cctacgagtc tgacgggatc     1500

gtggtttcca acgacacata ccgtgacctc caaggcgagc ggcaggagtg gaagcgcttc     1560

atcgaggagc ggctgctcat gtactccttc gtcaatgaca agtttatgcc ccctgatgac     1620

ccactgggcc ggcacgggcc cagcctggac aacttcctgc gtaagaagcc actcactttg     1680

gagtaa                                                                1686


<210>  461
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  15PUF - frame 3

<400>  461

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Tyr Val Val Arg 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser His Ile Met Glu Phe 
        275                 280                 285             


Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg 
    290                 295                 300                 


Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala 
305                 310                 315                 320 


Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys 
                325                 330                 335     


Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg 
            340                 345                 350         


Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr 
        355                 360                 365             


Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu 
    370                 375                 380                 


Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln 
385                 390                 395                 400 


Asn Gly Ser Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln 
                405                 410                 415     


Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu 
            420                 425                 430         


Ser Thr His Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His 
        435                 440                 445             


Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His 
    450                 455                 460                 


Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His 
465                 470                 475                 480 


Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu 
                485                 490                 495     


Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn 
            500                 505                 510         


Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val 
        515                 520                 525             


Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu 
    530                 535                 540                 


Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met 
545                 550                 555                 560 


Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile 
                565                 570                 575     


Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile 
            580                 585                 590         


Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
        595                 600                 605             


<210>  462
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  462

Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu 
1               5                   10      


<210>  463
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  463

Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe 
1               5                   10      


<210>  464
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  464

Met Tyr Gly Cys Arg Val Ile Gln Lys Ala Leu 
1               5                   10      


<210>  465
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  465

Gln Asn Gly Asn His Val Val Gln Lys Cys Ile 
1               5                   10      


<210>  466
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  466

Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu 
1               5                   10      


<210>  467
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  467

Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu 
1               5                   10      


<210>  468
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  468

Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val 
1               5                   10      


<210>  469
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  469

Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile 
1               5                   10      


<210>  470
<211>  1047
<212>  DNA
<213>  Homo sapiens

<400>  470
ggcaggagca ggcttttgga agattttcga aacaaccggt accccaattt acaactgcgg       60

gagattgctg gacatataat ggaattttcc caagaccagc atgggtccag attcattcag      120

ctgaaactgg agcgtgccac accagctgag cgccagcttg tcttcaatga aatcctccag      180

gctgcctacc aactcatggt ggatgtgttt ggtaattacg tcattcagaa gttctttgaa      240

tttggcagtc ttgaacagaa gctggctttg gcagaacgga ttcgaggcca cgtcctgtca      300

ttggcactac agatgtatgg ctgccgtgtt atccagaaag ctcttgagtt tattccttca      360

gaccagcaga atgagatggt tcgggaacta gatggccatg tcttgaagtg tgtgaaagat      420

cagaatggca atcacgtggt tcagaaatgc attgaatgtg tacagcccca gtctttgcaa      480

tttatcatcg atgcgtttaa gggacaggta tttgccttat ccacacatcc ttatggctgc      540

cgagtgattc agagaatcct ggagcactgt ctccctgacc agacactccc tattttagag      600

gagcttcacc agcacacaga gcagcttgta caggatcaat atggaaatta tgtaatccaa      660

catgtactgg agcacggtcg tcctgaggat aaaagcaaaa ttgtagcaga aatccgaggc      720

aatgtacttg tattgagtca gcacaaattt gcaagcaatg ttgtggagaa gtgtgttact      780

cacgcctcac gtacggagcg cgctgtgctc atcgatgagg tgtgcaccat gaacgacggt      840

ccccacagtg ccttatacac catgatgaag gaccagtatg ccaactacgt ggtccagaag      900

atgattgacg tggcggagcc aggccagcgg aagatcgtca tgcataagat ccggccccac      960

atcgcaactc ttcgtaagta cacctatggc aagcacattc tggccaagct ggagaagtac     1020

tacatgaaga acggtgttga cttaggg                                         1047


<210>  471
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  471

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Val Ile Asn Glu Met 
        115                 120                 125             


Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn 
    130                 135                 140                 


Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser 
145                 150                 155                 160 


Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser 
                165                 170                 175     


Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys 
            180                 185                 190         


Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr 
        195                 200                 205             


Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val 
    210                 215                 220                 


Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile 
225                 230                 235                 240 


Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val 
                245                 250                 255     


Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu 
            260                 265                 270         


Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr 
        275                 280                 285             


Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile 
    290                 295                 300                 


Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg 
305                 310                 315                 320 


Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu 
                325                 330                 335     


Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 350     


<210>  472
<211>  8
<212>  RNA
<213>  Homo sapiens

<400>  472
cugcugcu                                                                 8


<210>  473
<211>  14
<212>  RNA
<213>  Homo sapiens

<400>  473
cugcugcugc ugcu                                                         14


<210>  474
<211>  15
<212>  RNA
<213>  Homo sapiens

<400>  474
cugcugcugc ugcug                                                        15


<210>  475
<211>  16
<212>  RNA
<213>  Homo sapiens

<400>  475
cugcugcugc ugcugc                                                       16


<210>  476
<211>  8
<212>  RNA
<213>  Homo sapiens

<400>  476
gcugcugc                                                                 8


<210>  477
<211>  14
<212>  RNA
<213>  Homo sapiens

<400>  477
gcugcugcug cugc                                                         14


<210>  478
<211>  15
<212>  RNA
<213>  Homo sapiens

<400>  478
gcugcugcug cugcu                                                        15


<210>  479
<211>  16
<212>  RNA
<213>  Homo sapiens

<400>  479
gcugcugcug cugcug                                                       16


<210>  480
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF - frame 1

<400>  480

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Arg Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  481
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  14PUF - frame 1

<400>  481

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Ile Met Glu 
        195                 200                 205             


Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu 
    210                 215                 220                 


Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln 
225                 230                 235                 240 


Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln 
                245                 250                 255     


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            260                 265                 270         


Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser 
        275                 280                 285             


Tyr Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn 
    290                 295                 300                 


Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp 
305                 310                 315                 320 


Gln Asn Gly Ser Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro 
                325                 330                 335     


Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala 
            340                 345                 350         


Leu Ser Thr His Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu 
        355                 360                 365             


His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln 
    370                 375                 380                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg 
385                 390                 395                 400 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                405                 410                 415     


Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
            420                 425                 430         


Tyr Val Ile Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His 
    450                 455                 460                 


Lys Phe Ala Asn Asn Val Val Gln Lys Cys Val Thr His Ala Ser Arg 
465                 470                 475                 480 


Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly 
                485                 490                 495     


Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr 
            500                 505                 510         


Val Val Arg Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile 
        515                 520                 525             


Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr 
    530                 535                 540                 


Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn 
545                 550                 555                 560 


Gly Val Asp Leu Gly 
                565 


<210>  482
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  14PUF - frame 1

<400>  482

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


His Ile Met Glu Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln 
                245                 250                 255     


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            260                 265                 270         


Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser 
        275                 280                 285             


Tyr Val Ile Arg Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu 
    290                 295                 300                 


Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln 
305                 310                 315                 320 


Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser 
                325                 330                 335     


Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys 
            340                 345                 350         


Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu 
        355                 360                 365             


Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly 
    370                 375                 380                 


Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Arg 
385                 390                 395                 400 


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
                405                 410                 415     


Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
            420                 425                 430         


Tyr Val Ile Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His 
    450                 455                 460                 


Lys Phe Ala Asn Asn Val Val Gln Lys Cys Val Thr His Ala Ser Arg 
465                 470                 475                 480 


Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly 
                485                 490                 495     


Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr 
            500                 505                 510         


Val Val Arg Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile 
        515                 520                 525             


Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr 
    530                 535                 540                 


Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn 
545                 550                 555                 560 


Gly Val Asp Leu Gly 
                565 


<210>  483
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  15PUF - frame 1

<400>  483

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Ile Met Glu 
        195                 200                 205             


Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu 
    210                 215                 220                 


Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln 
225                 230                 235                 240 


Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu 
                245                 250                 255     


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            260                 265                 270         


Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn 
        275                 280                 285             


Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn 
    290                 295                 300                 


Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp 
305                 310                 315                 320 


Gln Asn Gly Ser Tyr Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro 
                325                 330                 335     


Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala 
            340                 345                 350         


Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu 
        355                 360                 365             


His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln 
    370                 375                 380                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln 
385                 390                 395                 400 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                405                 410                 415     


Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser 
            420                 425                 430         


Tyr Val Val Arg Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala 
        435                 440                 445             


Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser His 
    450                 455                 460                 


Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His 
465                 470                 475                 480 


Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu 
                485                 490                 495     


Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn 
            500                 505                 510         


Val Val Gln Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val 
        515                 520                 525             


Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu 
    530                 535                 540                 


Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Arg Lys Met 
545                 550                 555                 560 


Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile 
                565                 570                 575     


Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile 
            580                 585                 590         


Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
        595                 600                 605             


<210>  484
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  15PUF - frame 1

<400>  484

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu 
                245                 250                 255     


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            260                 265                 270         


Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn 
        275                 280                 285             


Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu 
    290                 295                 300                 


Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln 
305                 310                 315                 320 


Met Tyr Gly Ser Tyr Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser 
                325                 330                 335     


Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys 
            340                 345                 350         


Cys Val Lys Asp Gln Asn Gly Ser Tyr Val Val Glu Lys Cys Ile Glu 
        355                 360                 365             


Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly 
    370                 375                 380                 


Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Asn Arg Val Ile Gln 
385                 390                 395                 400 


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
                405                 410                 415     


Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
            420                 425                 430         


Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His 
    450                 455                 460                 


Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg 
465                 470                 475                 480 


Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly 
                485                 490                 495     


Pro His Ser Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn 
            500                 505                 510         


Val Val Gln Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val 
        515                 520                 525             


Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu 
    530                 535                 540                 


Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Arg Lys Met 
545                 550                 555                 560 


Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile 
                565                 570                 575     


Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile 
            580                 585                 590         


Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
        595                 600                 605             


<210>  485
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  15PUF - frame 1

<400>  485

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser His Ile Met Glu Phe 
        275                 280                 285             


Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg 
    290                 295                 300                 


Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala 
305                 310                 315                 320 


Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys 
                325                 330                 335     


Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg 
            340                 345                 350         


Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg 
        355                 360                 365             


Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu 
    370                 375                 380                 


Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln 
385                 390                 395                 400 


Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln 
                405                 410                 415     


Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu 
            420                 425                 430         


Ser Thr His Pro Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu His 
        435                 440                 445             


Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His 
    450                 455                 460                 


Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His 
465                 470                 475                 480 


Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu 
                485                 490                 495     


Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn 
            500                 505                 510         


Val Val Gln Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val 
        515                 520                 525             


Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu 
    530                 535                 540                 


Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Arg Lys Met 
545                 550                 555                 560 


Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile 
                565                 570                 575     


Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile 
            580                 585                 590         


Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
        595                 600                 605             


<210>  486
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUF - frame 1

<400>  486

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Ile Met Glu 
        195                 200                 205             


Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu 
    210                 215                 220                 


Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln 
225                 230                 235                 240 


Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg 
                245                 250                 255     


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            260                 265                 270         


Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser 
        275                 280                 285             


Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn 
    290                 295                 300                 


Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp 
305                 310                 315                 320 


Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro 
                325                 330                 335     


Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala 
            340                 345                 350         


Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu 
        355                 360                 365             


His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln 
    370                 375                 380                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu 
385                 390                 395                 400 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                405                 410                 415     


Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn 
            420                 425                 430         


Asn Val Val Gln Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala 
        435                 440                 445             


Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala 
    450                 455                 460                 


Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Arg Lys 
465                 470                 475                 480 


Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys 
                485                 490                 495     


Ile Arg Pro His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr 
            500                 505                 510         


Val Ile Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
        515                 520                 525             


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
    530                 535                 540                 


Phe Ala Asn Asn Val Val Gln Lys Cys Val Thr His Ala Ser Arg Thr 
545                 550                 555                 560 


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
                565                 570                 575     


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val 
            580                 585                 590         


Val Arg Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
        595                 600                 605             


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
    610                 615                 620                 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
625                 630                 635                 640 


Val Asp Leu Gly 
                


<210>  487
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUF - frame 1

<400>  487

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Arg 
                245                 250                 255     


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            260                 265                 270         


Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser 
        275                 280                 285             


Tyr Val Ile Glu Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu 
    290                 295                 300                 


Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln 
305                 310                 315                 320 


Met Tyr Gly Asn Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser 
                325                 330                 335     


Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys 
            340                 345                 350         


Cys Val Lys Asp Gln Asn Gly Ser Tyr Val Val Arg Lys Cys Ile Glu 
        355                 360                 365             


Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly 
    370                 375                 380                 


Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Glu 
385                 390                 395                 400 


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
                405                 410                 415     


Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn 
            420                 425                 430         


Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His 
    450                 455                 460                 


Lys Phe Ala Ser Tyr Val Val Arg Lys Cys Val Thr His Ala Ser Arg 
465                 470                 475                 480 


Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly 
                485                 490                 495     


Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr 
            500                 505                 510         


Val Val Glu Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile 
        515                 520                 525             


Val Met His Lys Ile Arg Pro Asn Val Leu Val Leu Ser Gln His Lys 
    530                 535                 540                 


Phe Ala Asn Asn Val Val Gln Lys Cys Val Thr His Ala Ser Arg Thr 
545                 550                 555                 560 


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
                565                 570                 575     


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val 
            580                 585                 590         


Val Arg Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
        595                 600                 605             


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
    610                 615                 620                 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
625                 630                 635                 640 


Val Asp Leu Gly 
                


<210>  488
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUF - frame 1

<400>  488

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Tyr Val Val Arg 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Glu Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Met Glu Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln Leu 
                325                 330                 335     


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
            340                 345                 350         


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr 
        355                 360                 365             


Val Ile Arg Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
    370                 375                 380                 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
385                 390                 395                 400 


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
                405                 410                 415     


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
            420                 425                 430         


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
        435                 440                 445             


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
    450                 455                 460                 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Arg Arg 
465                 470                 475                 480 


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
                485                 490                 495     


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr 
            500                 505                 510         


Val Ile Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
        515                 520                 525             


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
    530                 535                 540                 


Phe Ala Asn Asn Val Val Gln Lys Cys Val Thr His Ala Ser Arg Thr 
545                 550                 555                 560 


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
                565                 570                 575     


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val 
            580                 585                 590         


Val Arg Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
        595                 600                 605             


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
    610                 615                 620                 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
625                 630                 635                 640 


Val Asp Leu Gly 
                


<210>  489
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R8 G recognition sequence

<400>  489

Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Arg 
1               5                   10                  15      


Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His 
            20                  25                  30          


Lys Ile Arg Pro 
        35      


<210>  490
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R2 U recognition sequence

<400>  490

Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln 
1               5                   10                  15      


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            20                  25                  30          


Arg Ile Arg Gly 
        35      


<210>  491
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R2 G recognition sequence

<400>  491

Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu 
1               5                   10                  15      


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            20                  25                  30          


Arg Ile Arg Gly 
        35      


<210>  492
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R2 C recognition sequence

<400>  492

Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg 
1               5                   10                  15      


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            20                  25                  30          


Arg Ile Arg Gly 
        35      


<210>  493
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R8 U recognition sequence

<400>  493

Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln 
1               5                   10                  15      


Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His 
            20                  25                  30          


Lys Ile Arg Pro 
        35      


<210>  494
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R8 C recognition sequence

<400>  494

Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Arg 
1               5                   10                  15      


Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His 
            20                  25                  30          


Lys Ile Arg Pro 
        35      


<210>  495
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R1' sequence

<400>  495

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly 
            20                  


<210>  496
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R8' sequence

<400>  496

His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala 
1               5                   10                  15      


Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            20                  25                  30  


<210>  497
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R1 U recognition sequence

<400>  497

His Ile Met Glu Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln 
1               5                   10                  15      


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            20                  25                  30          


Glu Ile Leu Gln 
        35      


<210>  498
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R1 G recognition sequence

<400>  498

His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu 
1               5                   10                  15      


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            20                  25                  30          


Glu Ile Leu Gln 
        35      


<210>  499
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R1 C recognition sequence

<400>  499

His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Arg 
1               5                   10                  15      


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            20                  25                  30          


Glu Ile Leu Gln 
        35      


<210>  500
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R6 U recognition sequence

<400>  500

His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln 
1               5                   10                  15      


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
            20                  25                  30          


Glu Ile Arg Gly 
        35      


<210>  501
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R6 G recognition sequence

<400>  501

His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu 
1               5                   10                  15      


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
            20                  25                  30          


Glu Ile Arg Gly 
        35      


<210>  502
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R6 C recognition sequence

<400>  502

His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg 
1               5                   10                  15      


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
            20                  25                  30          


Glu Ile Arg Gly 
        35      


<210>  503
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R4 U recognition sequence

<400>  503

His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln 
1               5                   10                  15      


Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp 
            20                  25                  30          


Ala Phe Lys Gly 
        35      


<210>  504
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R4 G recognition sequence

<400>  504

His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser Tyr Val Val Glu 
1               5                   10                  15      


Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp 
            20                  25                  30          


Ala Phe Lys Gly 
        35      


<210>  505
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R4 C recognition sequence

<400>  505

His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser Tyr Val Val Arg 
1               5                   10                  15      


Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp 
            20                  25                  30          


Ala Phe Lys Gly 
        35      


<210>  506
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R3 U recognition sequence

<400>  506

His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln 
1               5                   10                  15      


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
            20                  25                  30          


Glu Leu Asp Gly 
        35      


<210>  507
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R3 G recognition sequence

<400>  507

His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
1               5                   10                  15      


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
            20                  25                  30          


Glu Leu Asp Gly 
        35      


<210>  508
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R3 C recognition sequence

<400>  508

His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg 
1               5                   10                  15      


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
            20                  25                  30          


Glu Leu Asp Gly 
        35      


<210>  509
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R7 U recognition sequence

<400>  509

Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln 
1               5                   10                  15      


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            20                  25                  30          


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser 
        35                  40              


<210>  510
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R7 G recognition sequence

<400>  510

Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
1               5                   10                  15      


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            20                  25                  30          


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser 
        35                  40              


<210>  511
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R7 C recognition sequence

<400>  511

Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Tyr Val Val Arg 
1               5                   10                  15      


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            20                  25                  30          


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser 
        35                  40              


<210>  512
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R5 U recognition sequence

<400>  512

Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Asn Arg Val Ile Gln 
1               5                   10                  15      


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
            20                  25                  30          


Glu Leu His Gln 
        35      


<210>  513
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R5 G recognition sequence

<400>  513

Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Glu 
1               5                   10                  15      


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
            20                  25                  30          


Glu Leu His Gln 
        35      


<210>  514
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PUF R5 C recognition sequence

<400>  514

Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Arg 
1               5                   10                  15      


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
            20                  25                  30          


Glu Leu His Gln 
        35      


<210>  515
<211>  1680
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  PUF8 CUG Nucleotide Sequence (whole insert including Flag tag, Sv-40 NLS, PUF and E17 fusion)

<400>  515
gactataaag atgacgatga taaacccaaa aagaaacgca aggtgggacg aagccgactc       60

ttggaagact tcagaaacaa tcggtatccg aaccttcagc tgagagaaat tgctggtcac      120

atcatggaat tttctcaaga tcaacatgga agccggttta ttgaacttaa actcgaacga      180

gccaccccgg ccgaaaggca attggtgttc aatgaaattc ttcaggccgc ataccaactc      240

atggttgatg tttttgggaa ctatgttatt caaaagtttt ttgagttcgg gtcactggag      300

caaaagttgg cattggcaga gcgaatccgg ggccatgttc tgagcctcgc tctccaaatg      360

tacggtagtt atgtcattcg caaagcactc gagttcatac catcagatca acagaatgag      420

atggtgcggg agctggatgg gcatgttttg aaatgcgtga aagaccaaaa cggtagctac      480

gtagttgaga aatgcatcga atgcgtccaa ccacagtctc tccaatttat tatagatgca      540

tttaagggtc aggttttcgc gctttctacg cacccgtatg ggaaccgagt gattcagaga      600

atcttggagc actgcctgcc ggatcagaca ctccctatct tggaggaatt gcaccagcat      660

accgaacaat tggtgcaaga tcaatacggt tcatatgtta ttcggcacgt tcttgagcat      720

ggaaggccag aggacaagtc aaagatcgtc gctgagatta gaggtaacgt attggtgctc      780

tcacaacaca aatttgcatc taatgtggtg gagaaatgtg ttactcatgc ttctagaacg      840

gaaagggcag ttctcataga cgaagtttgc acaatgaatg atggtcctca tagcgcactt      900

tataccatga tgaaggacca gtatgcaaac tatgtcgtcc agaaaatgat cgatgtggcg      960

gagcccggtc aacggaaaat cgtgatgcac aaaatccgac ctcacattgc tacactcaga     1020

aaatacacgt atggaaaaca tattctggct aagctggaga aatattacat gaagaatgga     1080

gtggatctgg gggtggatac tgccaatggc agcggtggtg gcacccctaa ggctcccaac     1140

ctggagcctc cactcccaga agaggaaaag gagggcagcg acctgagacc agtggtcatc     1200

gatgggagca acgtggccat gagccatggg aacaaggagg tcttctcctg ccggggcatc     1260

ctgctggcag tgaactggtt tctggagcgg ggccacacag acatcacagt gtttgtgcca     1320

tcctggagga aggagcagcc tcggcccgac gtgcccatca cagaccagca catcctgcgg     1380

gaactggaga agaagaagat cctggtgttc acaccatcac gacgcgtggg tggcaagcgg     1440

gtggtgtgct atgacgacag attcattgtg aagctggcct acgagtctga cgggatcgtg     1500

gtttccaacg acacataccg tgacctccaa ggcgagcggc aggagtggaa gcgcttcatc     1560

gaggagcggc tgctcatgta ctccttcgtc aatgacaagt ttatgccccc tgatgaccca     1620

ctgggccggc acgggcccag cctggacaac ttcctgcgta agaagccact cactttggag     1680


<210>  516
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  PUF8 CUG Nucleotide Sequence (including PUF and E17 fusion no tags)

<400>  516
ggacgaagcc gactcttgga agacttcaga aacaatcggt atccgaacct tcagctgaga       60

gaaattgctg gtcacatcat ggaattttct caagatcaac atggaagccg gtttattgaa      120

cttaaactcg aacgagccac cccggccgaa aggcaattgg tgttcaatga aattcttcag      180

gccgcatacc aactcatggt tgatgttttt gggaactatg ttattcaaaa gttttttgag      240

ttcgggtcac tggagcaaaa gttggcattg gcagagcgaa tccggggcca tgttctgagc      300

ctcgctctcc aaatgtacgg tagttatgtc attcgcaaag cactcgagtt cataccatca      360

gatcaacaga atgagatggt gcgggagctg gatgggcatg ttttgaaatg cgtgaaagac      420

caaaacggta gctacgtagt tgagaaatgc atcgaatgcg tccaaccaca gtctctccaa      480

tttattatag atgcatttaa gggtcaggtt ttcgcgcttt ctacgcaccc gtatgggaac      540

cgagtgattc agagaatctt ggagcactgc ctgccggatc agacactccc tatcttggag      600

gaattgcacc agcataccga acaattggtg caagatcaat acggttcata tgttattcgg      660

cacgttcttg agcatggaag gccagaggac aagtcaaaga tcgtcgctga gattagaggt      720

aacgtattgg tgctctcaca acacaaattt gcatctaatg tggtggagaa atgtgttact      780

catgcttcta gaacggaaag ggcagttctc atagacgaag tttgcacaat gaatgatggt      840

cctcatagcg cactttatac catgatgaag gaccagtatg caaactatgt cgtccagaaa      900

atgatcgatg tggcggagcc cggtcaacgg aaaatcgtga tgcacaaaat ccgacctcac      960

attgctacac tcagaaaata cacgtatgga aaacatattc tggctaagct ggagaaatat     1020

tacatgaaga atggagtgga tctgggggtg gatactgcca atggcagcgg tggtggcacc     1080

cctaaggctc ccaacctgga gcctccactc ccagaagagg aaaaggaggg cagcgacctg     1140

agaccagtgg tcatcgatgg gagcaacgtg gccatgagcc atgggaacaa ggaggtcttc     1200

tcctgccggg gcatcctgct ggcagtgaac tggtttctgg agcggggcca cacagacatc     1260

acagtgtttg tgccatcctg gaggaaggag cagcctcggc ccgacgtgcc catcacagac     1320

cagcacatcc tgcgggaact ggagaagaag aagatcctgg tgttcacacc atcacgacgc     1380

gtgggtggca agcgggtggt gtgctatgac gacagattca ttgtgaagct ggcctacgag     1440

tctgacggga tcgtggtttc caacgacaca taccgtgacc tccaaggcga gcggcaggag     1500

tggaagcgct tcatcgagga gcggctgctc atgtactcct tcgtcaatga caagtttatg     1560

ccccctgatg acccactggg ccggcacggg cccagcctgg acaacttcct gcgtaagaag     1620

ccactcactt tggag                                                      1635


<210>  517
<211>  1656
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  PUF8 CUG Nucleotide Sequence (including Sv-40 NLS PUF and E17 fusion)

<400>  517
cccaaaaaga aacgcaaggt gggacgaagc cgactcttgg aagacttcag aaacaatcgg       60

tatccgaacc ttcagctgag agaaattgct ggtcacatca tggaattttc tcaagatcaa      120

catggaagcc ggtttattga acttaaactc gaacgagcca ccccggccga aaggcaattg      180

gtgttcaatg aaattcttca ggccgcatac caactcatgg ttgatgtttt tgggaactat      240

gttattcaaa agttttttga gttcgggtca ctggagcaaa agttggcatt ggcagagcga      300

atccggggcc atgttctgag cctcgctctc caaatgtacg gtagttatgt cattcgcaaa      360

gcactcgagt tcataccatc agatcaacag aatgagatgg tgcgggagct ggatgggcat      420

gttttgaaat gcgtgaaaga ccaaaacggt agctacgtag ttgagaaatg catcgaatgc      480

gtccaaccac agtctctcca atttattata gatgcattta agggtcaggt tttcgcgctt      540

tctacgcacc cgtatgggaa ccgagtgatt cagagaatct tggagcactg cctgccggat      600

cagacactcc ctatcttgga ggaattgcac cagcataccg aacaattggt gcaagatcaa      660

tacggttcat atgttattcg gcacgttctt gagcatggaa ggccagagga caagtcaaag      720

atcgtcgctg agattagagg taacgtattg gtgctctcac aacacaaatt tgcatctaat      780

gtggtggaga aatgtgttac tcatgcttct agaacggaaa gggcagttct catagacgaa      840

gtttgcacaa tgaatgatgg tcctcatagc gcactttata ccatgatgaa ggaccagtat      900

gcaaactatg tcgtccagaa aatgatcgat gtggcggagc ccggtcaacg gaaaatcgtg      960

atgcacaaaa tccgacctca cattgctaca ctcagaaaat acacgtatgg aaaacatatt     1020

ctggctaagc tggagaaata ttacatgaag aatggagtgg atctgggggt ggatactgcc     1080

aatggcagcg gtggtggcac ccctaaggct cccaacctgg agcctccact cccagaagag     1140

gaaaaggagg gcagcgacct gagaccagtg gtcatcgatg ggagcaacgt ggccatgagc     1200

catgggaaca aggaggtctt ctcctgccgg ggcatcctgc tggcagtgaa ctggtttctg     1260

gagcggggcc acacagacat cacagtgttt gtgccatcct ggaggaagga gcagcctcgg     1320

cccgacgtgc ccatcacaga ccagcacatc ctgcgggaac tggagaagaa gaagatcctg     1380

gtgttcacac catcacgacg cgtgggtggc aagcgggtgg tgtgctatga cgacagattc     1440

attgtgaagc tggcctacga gtctgacggg atcgtggttt ccaacgacac ataccgtgac     1500

ctccaaggcg agcggcagga gtggaagcgc ttcatcgagg agcggctgct catgtactcc     1560

ttcgtcaatg acaagtttat gccccctgat gacccactgg gccggcacgg gcccagcctg     1620

gacaacttcc tgcgtaagaa gccactcact ttggag                               1656


<210>  518
<211>  3919
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasRx-CTGguide3- whole nucleotide sequence from U6 promoter to BGH poly A

<400>  518
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg aacccctacc aactggtcgg ggtttgaaac cagcagcagc agcagcagca      300

gcagcatttt tttcctgcag cccggaccgg tctaggtctt gaaaggagtg ggaattggct      360

ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag ttggggggag      420

gggtcggcaa ttgatccggt gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg      480

tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata agtgcagtag      540

tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacaggac actgtgctgg      600

atatctgcag agaaccatga gccccaagaa gaagagaaag gtggaggcca gcatcgaaaa      660

aaaaaagtcc ttcgccaagg gcatgggcgt gaagtccaca ctcgtgtccg gctccaaagt      720

gtacatgaca accttcgccg aaggcagcga cgccaggctg gaaaagatcg tggagggcga      780

cagcatcagg agcgtgaatg agggcgaggc cttcagcgct gaaatggccg ataaaaacgc      840

cggctataag atcggcaacg ccaaattcag ccatcctaag ggctacgccg tggtggctaa      900

caaccctctg tatacaggac ccgtccagca ggatatgctc ggcctgaagg aaactctgga      960

aaagaggtac ttcggcgaga gcgctgatgg caatgacaat atttgtatcc aggtgatcca     1020

taacatcctg gacattgaaa aaatcctcgc cgaatacatt accaacgccg cctacgccgt     1080

caacaatatc tccggcctgg ataaggacat tattggattc ggcaagttct ccacagtgta     1140

tacctacgac gaattcaaag accccgagca ccatagggcc gctttcaaca ataacgataa     1200

gctcatcaac gccatcaagg cccagtatga cgagttcgac aacttcctcg ataaccccag     1260

actcggctat ttcggccagg cctttttcag caaggagggc agaaattaca tcatcaatta     1320

cggcaacgaa tgctatgaca ttctggccct cctgagcgga ctgaggcact gggtggtcca     1380

taacaacgaa gaagagtcca ggatctccag gacctggctc tacaacctcg ataagaacct     1440

cgacaacgaa tacatctcca ccctcaacta cctctacgac aggatcacca atgagctgac     1500

caactccttc tccaagaact ccgccgccaa cgtgaactat attgccgaaa ctctgggaat     1560

caaccctgcc gaattcgccg aacaatattt cagattcagc attatgaaag agcagaaaaa     1620

cctcggattc aatatcacca agctcaggga agtgatgctg gacaggaagg atatgtccga     1680

gatcaggaaa aatcataagg tgttcgactc catcaggacc aaggtctaca ccatgatgga     1740

ctttgtgatt tataggtatt acatcgaaga ggatgccaag gtggctgccg ccaataagtc     1800

cctccccgat aatgagaagt ccctgagcga gaaggatatc tttgtgatta acctgagggg     1860

ctccttcaac gacgaccaga aggatgccct ctactacgat gaagctaata gaatttggag     1920

aaagctcgaa aatatcatgc acaacatcaa ggaatttagg ggaaacaaga caagagagta     1980

taagaagaag gacgccccta gactgcccag aatcctgccc gctggccgtg atgtttccgc     2040

cttcagcaaa ctcatgtatg ccctgaccat gttcctggat ggcaaggaga tcaacgacct     2100

cctgaccacc ctgattaata aattcgataa catccagagc ttcctgaagg tgatgcctct     2160

catcggagtc aacgctaagt tcgtggagga atacgccttt ttcaaagact ccgccaagat     2220

cgccgatgag ctgaggctga tcaagtcctt cgctagaatg ggagaaccta ttgccgatgc     2280

caggagggcc atgtatatcg acgccatccg tattttagga accaacctgt cctatgatga     2340

gctcaaggcc ctcgccgaca ccttttccct ggacgagaac ggaaacaagc tcaagaaagg     2400

caagcacggc atgagaaatt tcattattaa taacgtgatc agcaataaaa ggttccacta     2460

cctgatcaga tacggtgatc ctgcccacct ccatgagatc gccaaaaacg aggccgtggt     2520

gaagttcgtg ctcggcagga tcgctgacat ccagaaaaaa cagggccaga acggcaagaa     2580

ccagatcgac aggtactacg aaacttgtat cggaaaggat aagggcaaga gcgtgagcga     2640

aaaggtggac gctctcacaa agatcatcac cggaatgaac tacgaccaat tcgacaagaa     2700

aaggagcgtc attgaggaca ccggcaggga aaacgccgag agggagaagt ttaaaaagat     2760

catcagcctg tacctcaccg tgatctacca catcctcaag aatattgtca atatcaacgc     2820

caggtacgtc atcggattcc attgcgtcga gcgtgatgct caactgtaca aggagaaagg     2880

ctacgacatc aatctcaaga aactggaaga gaagggattc agctccgtca ccaagctctg     2940

cgctggcatt gatgaaactg cccccgataa gagaaaggac gtggaaaagg agatggctga     3000

aagagccaag gagagcattg acagcctcga gagcgccaac cccaagctgt atgccaatta     3060

catcaaatac agcgacgaga agaaagccga ggagttcacc aggcagatta acagggagaa     3120

ggccaaaacc gccctgaacg cctacctgag gaacaccaag tggaatgtga tcatcaggga     3180

ggacctcctg agaattgaca acaagacatg taccctgttc agaaacaagg ccgtccacct     3240

ggaagtggcc aggtatgtcc acgcctatat caacgacatt gccgaggtca attcctactt     3300

ccaactgtac cattacatca tgcagagaat tatcatgaat gagaggtacg agaaaagcag     3360

cggaaaggtg tccgagtact tcgacgctgt gaatgacgag aagaagtaca acgataggct     3420

cctgaaactg ctgtgtgtgc ctttcggcta ctgtatcccc aggtttaaga acctgagcat     3480

cgaggccctg ttcgatagga acgaggccgc caagttcgac aaggagaaaa agaaggtgtc     3540

cggcaattcc ggatccggac ctaagaaaaa gaggaaggtg gcggccgctt acccatacga     3600

tgttccagat tacgctgacg tgtaaccacc acactggact agtggatccg agctcggtac     3660

caagcttaag tttaaaccgc tgatcagcct cgactgtgcc ttctagttgc cagccatctg     3720

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt     3780

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg     3840

gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg     3900

atgcggtggg ctctatggc                                                  3919


<210>  519
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human U6 promoter

<400>  519
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacacc                                                              249


<210>  520
<211>  256
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  EFS promoter

<400>  520
taggtcttga aaggagtggg aattggctcc ggtgcccgtc agtgggcaga gcgcacatcg       60

cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gatccggtgc ctagagaagg      120

tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt tcccgagggt      180

gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg caacgggttt      240

gccgccagaa cacagg                                                      256


<210>  521
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  521
gaggccagc                                                                9


<210>  522
<211>  2898
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  casrx SEQ ID NO 144

<400>  522
atcgaaaaaa aaaagtcctt cgccaagggc atgggcgtga agtccacact cgtgtccggc       60

tccaaagtgt acatgacaac cttcgccgaa ggcagcgacg ccaggctgga aaagatcgtg      120

gagggcgaca gcatcaggag cgtgaatgag ggcgaggcct tcagcgctga aatggccgat      180

aaaaacgccg gctataagat cggcaacgcc aaattcagcc atcctaaggg ctacgccgtg      240

gtggctaaca accctctgta tacaggaccc gtccagcagg atatgctcgg cctgaaggaa      300

actctggaaa agaggtactt cggcgagagc gctgatggca atgacaatat ttgtatccag      360

gtgatccata acatcctgga cattgaaaaa atcctcgccg aatacattac caacgccgcc      420

tacgccgtca acaatatctc cggcctggat aaggacatta ttggattcgg caagttctcc      480

acagtgtata cctacgacga attcaaagac cccgagcacc atagggccgc tttcaacaat      540

aacgataagc tcatcaacgc catcaaggcc cagtatgacg agttcgacaa cttcctcgat      600

aaccccagac tcggctattt cggccaggcc tttttcagca aggagggcag aaattacatc      660

atcaattacg gcaacgaatg ctatgacatt ctggccctcc tgagcggact gaggcactgg      720

gtggtccata acaacgaaga agagtccagg atctccagga cctggctcta caacctcgat      780

aagaacctcg acaacgaata catctccacc ctcaactacc tctacgacag gatcaccaat      840

gagctgacca actccttctc caagaactcc gccgccaacg tgaactatat tgccgaaact      900

ctgggaatca accctgccga attcgccgaa caatatttca gattcagcat tatgaaagag      960

cagaaaaacc tcggattcaa tatcaccaag ctcagggaag tgatgctgga caggaaggat     1020

atgtccgaga tcaggaaaaa tcataaggtg ttcgactcca tcaggaccaa ggtctacacc     1080

atgatggact ttgtgattta taggtattac atcgaagagg atgccaaggt ggctgccgcc     1140

aataagtccc tccccgataa tgagaagtcc ctgagcgaga aggatatctt tgtgattaac     1200

ctgaggggct ccttcaacga cgaccagaag gatgccctct actacgatga agctaataga     1260

atttggagaa agctcgaaaa tatcatgcac aacatcaagg aatttagggg aaacaagaca     1320

agagagtata agaagaagga cgcccctaga ctgcccagaa tcctgcccgc tggccgtgat     1380

gtttccgcct tcagcaaact catgtatgcc ctgaccatgt tcctggatgg caaggagatc     1440

aacgacctcc tgaccaccct gattaataaa ttcgataaca tccagagctt cctgaaggtg     1500

atgcctctca tcggagtcaa cgctaagttc gtggaggaat acgccttttt caaagactcc     1560

gccaagatcg ccgatgagct gaggctgatc aagtccttcg ctagaatggg agaacctatt     1620

gccgatgcca ggagggccat gtatatcgac gccatccgta ttttaggaac caacctgtcc     1680

tatgatgagc tcaaggccct cgccgacacc ttttccctgg acgagaacgg aaacaagctc     1740

aagaaaggca agcacggcat gagaaatttc attattaata acgtgatcag caataaaagg     1800

ttccactacc tgatcagata cggtgatcct gcccacctcc atgagatcgc caaaaacgag     1860

gccgtggtga agttcgtgct cggcaggatc gctgacatcc agaaaaaaca gggccagaac     1920

ggcaagaacc agatcgacag gtactacgaa acttgtatcg gaaaggataa gggcaagagc     1980

gtgagcgaaa aggtggacgc tctcacaaag atcatcaccg gaatgaacta cgaccaattc     2040

gacaagaaaa ggagcgtcat tgaggacacc ggcagggaaa acgccgagag ggagaagttt     2100

aaaaagatca tcagcctgta cctcaccgtg atctaccaca tcctcaagaa tattgtcaat     2160

atcaacgcca ggtacgtcat cggattccat tgcgtcgagc gtgatgctca actgtacaag     2220

gagaaaggct acgacatcaa tctcaagaaa ctggaagaga agggattcag ctccgtcacc     2280

aagctctgcg ctggcattga tgaaactgcc cccgataaga gaaaggacgt ggaaaaggag     2340

atggctgaaa gagccaagga gagcattgac agcctcgaga gcgccaaccc caagctgtat     2400

gccaattaca tcaaatacag cgacgagaag aaagccgagg agttcaccag gcagattaac     2460

agggagaagg ccaaaaccgc cctgaacgcc tacctgagga acaccaagtg gaatgtgatc     2520

atcagggagg acctcctgag aattgacaac aagacatgta ccctgttcag aaacaaggcc     2580

gtccacctgg aagtggccag gtatgtccac gcctatatca acgacattgc cgaggtcaat     2640

tcctacttcc aactgtacca ttacatcatg cagagaatta tcatgaatga gaggtacgag     2700

aaaagcagcg gaaaggtgtc cgagtacttc gacgctgtga atgacgagaa gaagtacaac     2760

gataggctcc tgaaactgct gtgtgtgcct ttcggctact gtatccccag gtttaagaac     2820

ctgagcatcg aggccctgtt cgataggaac gaggccgcca agttcgacaa ggagaaaaag     2880

aaggtgtccg gcaattcc                                                   2898


<210>  523
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  523
ggatccgga                                                                9


<210>  524
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SV40 NLS Tag

<400>  524
cctaagaaaa agaggaaggt g                                                 21


<210>  525
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  525
gcggccgct                                                                9


<210>  526
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HA tag

<400>  526
tacccatacg atgttccaga ttacgct                                           27


<210>  527
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  BGH poly A

<400>  527
tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct       60

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct      120

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg      180

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggc                      225


<210>  528
<211>  3740
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Seq198-CTGguide3- whole nucleotide sequence from U6 promoter to SV-40 poly A

<400>  528
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattagaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg caagtaaacc cctaccaagt ggtcggggtt tgaaaccagc agcagcagca      300

gcagcagcag cattttttcc accacactgg actagtggat ctggatccct gcagccctcc      360

ttaggtcttg aaaggagtgg gaattggctc cggtgcccgt cagtgggcag agcgcacatc      420

gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgatccggtg cctagagaag      480

gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg      540

tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt      600

tgccgccaga acacaggtca cgcttaacta acgcgtgccg ccaccatgat cgaaaagaag      660

aagagctacg ctaaaggaat gggcctgaaa agcaccatcg tgtccggctc taaagtgtac      720

atgacaacct tcggcgatgg cagcgaggcc agactggaga aggtggttga gaacgatagc      780

atcaagaccc tgcacgaggg cgaggccttc agcgctgaga tgaccgacaa caacgccggc      840

tataagatcg gaaacgtgaa gttctcccac cctaacggct acgacgtggt cgccaacaac      900

cctttctaca ccggccctgt gcagcaggac atgctgggcc tgaaagaaat cctggaaaga      960

cggtactttg gatctagcac agacggtaac aataccatct gcatccaaat catccacaat     1020

atcctggata tcgaaaaaat tctggcagag tacatcacaa acgcagtgta cgccaccaac     1080

aacatcatcg atcctgataa cgacgtgatc ggcggcaaga agttcaccag cattaaaacc     1140

ttcgcccagt tctccgccag cgacagcagc aacgatttcg agcagttcct gaaaaatccc     1200

agactcggct acctgggcaa agcctttttc tacaaggacg gcaagcggaa caacagacag     1260

aaggatccta tcgagtgtta ccacctgctg gccctgctgt gcggcctgcg taattgggtt     1320

gtgcacaaca acgaggaaaa ggacctgatc aagtacacct ggttgtataa cctggacaag     1380

tacctggatg ccgagtacat caccaccctg aactacatgt acaacgacat cggcgacgag     1440

ttgacggact ctttctccaa gaacagcgcc gccaatatca actacatcgc cgagaccctg     1500

ggaatcgacc ccaagacctt cgccgagcaa tacttccggt tctctatcat gaaggaacag     1560

aaaaacctgg gattcaacct gaccaagctg agagaggtga tgctggaccg gaaggacatg     1620

agcgagatca gagagaacca caacgacttc gattctatca gagccaaggt gtacacaatg     1680

atggacttcg tgatctatcg gtactacatc gaagaggccg ctaaggtgaa cgccgccaac     1740

aagagcctgc ccgacaacga gaagagcctg agcgagaaag acatcttcgt gatttcactc     1800

agaggcagct tcaacgaaga tcagaaggat cggctgtact acgacgaggc gcaaagactg     1860

tggtccaagg tgggcaaact gatgctgaaa atcaagaagt tccggggcaa ggacaccaga     1920

aagtacaaga atatgggcac acctagaatc cggaggctga tccctgaggg cagagatatc     1980

agcaccttct ccaagctgat gtacgctctg actatgttcc tggacggcaa ggagatcaat     2040

gacctgctga ccacactgat caacaaattc gacaacatcc agagcttctt aaaggtgatg     2100

cctctgatcg gcgtgaacgc caaatttgcc gaagaatata gtttcttcaa caactctgaa     2160

aaaatcgccg acgaactgcg gctgatcaag agctttgcta gaatgggaga acccgtggct     2220

gacgccagaa gagccatgta tatcgacgca attcgcatcc tgggcaccga tctctccgac     2280

gacgagctga aggccctggc tgattctttt agcctggacg agaacggcaa taagctgggg     2340

aagggcaagc acggcatgag aaacttcatc attaacaacg tgataacaaa taagagattc     2400

cactacctga tccggtacgg caacccagtc cacctgcatg agatcgccaa gaatgaagcc     2460

gtggtcaagt ttgtgctggg aagaatcgcc gatatccaga agaaacaggg ccagaacggc     2520

aagaaccaga tcgatagata ctacgagaca tgcatcggca aggactcttc taaaagcgtg     2580

gccgagaagg tgaacgccct gaccaagatc atcacaggca tgaactacga ccagttcgac     2640

agcagacgga acgtgatcga aaacaccggc gccggcaacg ccgagagaga aaagtacaag     2700

aagatcatca gcctgtacct gacagtgatc taccacatcc tgaagaacat tgttaatatc     2760

aactcaagat acgtgatcgg atttcactgc gtggagagag atgcccagct gtataaggaa     2820

aagggctacg acattaatct gaaaaagctg aaagacaagg gattcacaag cgtgaccaag     2880

ctgtgcgccg gaatcgacga ggaatgcaag gacgtcgaaa aggaaatgac cgagcgggcc     2940

aaggcctctt tcgctgccct ggaaaccgcc aaccccaagc tgtacgccac atacatcaac     3000

tactctgatg aagagaagaa tgccgaactg agaaagcaga tcaatagaga gaaggccaaa     3060

accgccctga acgctcatct gcgcaacacc aagtggaacg tgatcatccg ggaagatctt     3120

ctgagaagag ataacaaggc ttgtaaaatc ttcagaaata aggtcgccca cctggaggcc     3180

atccgatacg ctcacctgta catcaacgac atcgctgagg tgaatagcta ttttcagttt     3240

taccactaca tcatgcagcg gaggatcatg gccgaacggt acgacaagag cagcggcaag     3300

gttagagaat acttcgacgc cgtgaacaat gagaaaaaat acaacgatag actgctgaag     3360

ctcctctgtg tgccattcgg ctactgcatc cctagattca agaatctgag catcgaggcc     3420

ctgttcgaca tgaacgaggc cgtgaagttt gataaggaaa agaagggatc ccccaaaaaa     3480

aaaaggaagg tgtaaggatc ctctagataa ctgatcataa tcagccatac cacatttgta     3540

gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg     3600

aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat     3660

agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc     3720

aaactcatca atgtatctta                                                 3740


<210>  529
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Kozak sequence

<400>  529
gccgccacca tg                                                           12


<210>  530
<211>  2817
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Cas13d seq198

<400>  530
atcgaaaaga agaagagcta cgctaaagga atgggcctga aaagcaccat cgtgtccggc       60

tctaaagtgt acatgacaac cttcggcgat ggcagcgagg ccagactgga gaaggtggtt      120

gagaacgata gcatcaagac cctgcacgag ggcgaggcct tcagcgctga gatgaccgac      180

aacaacgccg gctataagat cggaaacgtg aagttctccc accctaacgg ctacgacgtg      240

gtcgccaaca accctttcta caccggccct gtgcagcagg acatgctggg cctgaaagaa      300

atcctggaaa gacggtactt tggatctagc acagacggta acaataccat ctgcatccaa      360

atcatccaca atatcctgga tatcgaaaaa attctggcag agtacatcac aaacgcagtg      420

tacgccacca acaacatcat cgatcctgat aacgacgtga tcggcggcaa gaagttcacc      480

agcattaaaa ccttcgccca gttctccgcc agcgacagca gcaacgattt cgagcagttc      540

ctgaaaaatc ccagactcgg ctacctgggc aaagcctttt tctacaagga cggcaagcgg      600

aacaacagac agaaggatcc tatcgagtgt taccacctgc tggccctgct gtgcggcctg      660

cgtaattggg ttgtgcacaa caacgaggaa aaggacctga tcaagtacac ctggttgtat      720

aacctggaca agtacctgga tgccgagtac atcaccaccc tgaactacat gtacaacgac      780

atcggcgacg agttgacgga ctctttctcc aagaacagcg ccgccaatat caactacatc      840

gccgagaccc tgggaatcga ccccaagacc ttcgccgagc aatacttccg gttctctatc      900

atgaaggaac agaaaaacct gggattcaac ctgaccaagc tgagagaggt gatgctggac      960

cggaaggaca tgagcgagat cagagagaac cacaacgact tcgattctat cagagccaag     1020

gtgtacacaa tgatggactt cgtgatctat cggtactaca tcgaagaggc cgctaaggtg     1080

aacgccgcca acaagagcct gcccgacaac gagaagagcc tgagcgagaa agacatcttc     1140

gtgatttcac tcagaggcag cttcaacgaa gatcagaagg atcggctgta ctacgacgag     1200

gcgcaaagac tgtggtccaa ggtgggcaaa ctgatgctga aaatcaagaa gttccggggc     1260

aaggacacca gaaagtacaa gaatatgggc acacctagaa tccggaggct gatccctgag     1320

ggcagagata tcagcacctt ctccaagctg atgtacgctc tgactatgtt cctggacggc     1380

aaggagatca atgacctgct gaccacactg atcaacaaat tcgacaacat ccagagcttc     1440

ttaaaggtga tgcctctgat cggcgtgaac gccaaatttg ccgaagaata tagtttcttc     1500

aacaactctg aaaaaatcgc cgacgaactg cggctgatca agagctttgc tagaatggga     1560

gaacccgtgg ctgacgccag aagagccatg tatatcgacg caattcgcat cctgggcacc     1620

gatctctccg acgacgagct gaaggccctg gctgattctt ttagcctgga cgagaacggc     1680

aataagctgg ggaagggcaa gcacggcatg agaaacttca tcattaacaa cgtgataaca     1740

aataagagat tccactacct gatccggtac ggcaacccag tccacctgca tgagatcgcc     1800

aagaatgaag ccgtggtcaa gtttgtgctg ggaagaatcg ccgatatcca gaagaaacag     1860

ggccagaacg gcaagaacca gatcgataga tactacgaga catgcatcgg caaggactct     1920

tctaaaagcg tggccgagaa ggtgaacgcc ctgaccaaga tcatcacagg catgaactac     1980

gaccagttcg acagcagacg gaacgtgatc gaaaacaccg gcgccggcaa cgccgagaga     2040

gaaaagtaca agaagatcat cagcctgtac ctgacagtga tctaccacat cctgaagaac     2100

attgttaata tcaactcaag atacgtgatc ggatttcact gcgtggagag agatgcccag     2160

ctgtataagg aaaagggcta cgacattaat ctgaaaaagc tgaaagacaa gggattcaca     2220

agcgtgacca agctgtgcgc cggaatcgac gaggaatgca aggacgtcga aaaggaaatg     2280

accgagcggg ccaaggcctc tttcgctgcc ctggaaaccg ccaaccccaa gctgtacgcc     2340

acatacatca actactctga tgaagagaag aatgccgaac tgagaaagca gatcaataga     2400

gagaaggcca aaaccgccct gaacgctcat ctgcgcaaca ccaagtggaa cgtgatcatc     2460

cgggaagatc ttctgagaag agataacaag gcttgtaaaa tcttcagaaa taaggtcgcc     2520

cacctggagg ccatccgata cgctcacctg tacatcaacg acatcgctga ggtgaatagc     2580

tattttcagt tttaccacta catcatgcag cggaggatca tggccgaacg gtacgacaag     2640

agcagcggca aggttagaga atacttcgac gccgtgaaca atgagaaaaa atacaacgat     2700

agactgctga agctcctctg tgtgccattc ggctactgca tccctagatt caagaatctg     2760

agcatcgagg ccctgttcga catgaacgag gccgtgaagt ttgataagga aaagaag        2817


<210>  531
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  531
ggatcc                                                                   6


<210>  532
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SV40 NLS

<400>  532
cccaaaaaaa aaaggaaggt g                                                 21


<210>  533
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SV40 polyA

<400>  533
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

ta                                                                     122


<210>  534
<211>  3803
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Seq179-CTGguide3- whole nucleotide sequence from U6 promoter to SV-40 poly A

<400>  534
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattagaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg actatagccc tgccggaaat gacagggttc tacaaccagc agcagcagca      300

gcagcagcag cattttttcc accacactgg actagtggat ctggatccct gcagccctcc      360

ttaggtcttg aaaggagtgg gaattggctc cggtgcccgt cagtgggcag agcgcacatc      420

gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgatccggtg cctagagaag      480

gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg      540

tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt      600

tgccgccaga acacaggtca cgcttaacta acgcgtgccg ccaccatggc caaaaagaag      660

aaaaccgctc gccaactgag agaagaaatg caacaacagc ggaaacaggc cattcagaag      720

caacaagaac agagacaaga gaaagccgcc gccgctcgcg agacagccgc ccccgaacag      780

cctgctgccg ctcctgtgcc aaagcggcaa agaaaatctc tggccaaagc cgccggactg      840

aagtccaact tcatcttgga cccacagaga agaacaacag tgatgacagc ttttggccag      900

ggcagcaccg ccatcctgga gaagcagatc gtggacagag ccatcagcga cctgcagccg      960

gttcagcagt tccaagtgga acctgccagt gccgccaagt acaggctgaa gaatagccgg     1020

gtgagattcc ccaacgtgac agctgacgat cctctgtata gacggaagga tggcggcttc     1080

gtgcctggca tggacgccct cagaagaaag aacgtactgg aacagagatt cttcggcaag     1140

tctttcgccg ataacatcca catccagatg atctacagca tcctggacat ccacaagatc     1200

ctcgctgccg cgagcggcca catcgtgcac ctgctcaata tcgtgaatgg ctcaaaagat     1260

agagacttca tcggcatgct ggccgcccac gtgctgtaca atgagctgaa cgaggaggcc     1320

aagcggagca tcgccgactt ttgcaagagt cccagactga tctactactc tgctgctttc     1380

tacgagacat tggacaacgg caagagcgag cgacggtcta acgaggacat cttcaacatc     1440

ctggccctga tgacctgtct gagaaatttc agcagccacc acagcatcgc catcaaggtg     1500

aaggactaca gcgccgctgg cctgtacaac ctgcggagac tgggacctga catgaagaaa     1560

atgctggaca ccttctacac cgaggccttc atccagctta accagagctt ccaggaccac     1620

aacaccacaa acctgacatg tctgttcgat atcctgaaca tctctgatag cgccagacag     1680

aagcagctgg ctgaggaatt ttatagatac gtggtgttca aggaacaaaa gaacttggga     1740

ttctccgtgc ggaagctgag agaggaaatg ctgctgctgc cagacgctgc cgtgatcgcc     1800

gataagcggt acgacacctg cagatccaag ctgtacaacc tgatggactt cctgatcctg     1860

agagtgtaca gaaccggcag agccgacaga tgcgacaagc tgcctgaggc cctgcgggcc     1920

gccctgaccg acgaggaaaa ggccgtggtg taccacaaag aagccctgag cctgtggaac     1980

gagatgagaa ccctgatcct cgacggcctg ctgcctcaga tgacacctga gaacctgagc     2040

agactgtccg gtcagaaaag aaagggcgaa ctgtctctgg atgacgccat gctgaaagag     2100

tgcctgtacg agcccggacc tgtgcccgag gatgctgccc ctgaggaagc caacgccgag     2160

tacttctgcc ggatgatcta cctggccacc ctgtttatgg atggcaagga gatcaacacc     2220

ctgctgacca ccctgattag caaattcgag aacatcgccg ccttcctgca gaccatggaa     2280

cagctgaaca tcgaggccga gctgggccct gaatacgcca tgtttaccag aagcagagcc     2340

gtagccgagc agctgagagt gatcaacagc ttcgccctga tgaagaagcc tcaggtgaat     2400

gccaagcagc agctgtacag agccgctgtc accctgctgg gaacagagga ccctgacggc     2460

gtgaccgatg agatgctgtg catcgacccc gtgaccggca agatgctgcc tcctaaccag     2520

aggcatcatg gcgacaccgg cttacggaac ttcatcgcaa acaacgtggt ggaaagccgg     2580

agattccagt acttaatccg gtacagcgat cctgctcagc tgcaccagct cgccagcaac     2640

aagaagctgg tcagattcgt gctgagcagc atccccgaca cacagatcaa cagatactat     2700

gaaacctgtg gccagaccag actggccggc agagccgcca aggtggaatt cctgacagac     2760

atgattgccg ccatcagatt cgaccagttt cgggatgtca atcagaaaga gcgcggcgcc     2820

aatactcaga aagaaagata taaggccatg cttggcctgt accagaccgt gctgtacctg     2880

gctgttaaaa atctggtgaa cattaacgcc agatacgtga tggccttcca ctgcgtggag     2940

cgggatatgt ttctgtatga cggcgagctg acagatccca agggcgagag cgtgtctgct     3000

ttcctggctg tgaatggaaa gaagggcgtg cagcctcagt acctgctgct gacccagctg     3060

tttatccggc gggattacct taagcggagt gcatgcgagc agatccagca caacatggaa     3120

aacatctccg accggctgct gcgggaatac cggaacgccg tcgcccacct gaatgtgata     3180

gcccatctgg ctgactactc tgccgacatg agagaaatca ccagctacta cggcttgtat     3240

cactacctga tgcagagaca cctcttcaaa agacacgcct ggcagatcag acagcctgaa     3300

aggccaactg aggaggaaca gaagctcatc gagcaggagc agaagcagct ggcctgggag     3360

aaggccctgt ttgacaagac cctgcagtac cacagctaca acaaggacct ggtgaaggct     3420

cttaacgccc ccttcggata caacctggca agatacaaga acctgtctat cgagcctctg     3480

ttcagcaaag aagccgctcc tgccgccgag atcaaggcca cacacgccgg atcccccaaa     3540

aaaaaaagga aggtgtaagg atcctctaga taactgatca taatcagcca taccacattt     3600

gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa     3660

atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc     3720

aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg     3780

tccaaactca tcaatgtatc tta                                             3803


<210>  535
<211>  2880
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Cas13 Seq179

<400>  535
gccaaaaaga agaaaaccgc tcgccaactg agagaagaaa tgcaacaaca gcggaaacag       60

gccattcaga agcaacaaga acagagacaa gagaaagccg ccgccgctcg cgagacagcc      120

gcccccgaac agcctgctgc cgctcctgtg ccaaagcggc aaagaaaatc tctggccaaa      180

gccgccggac tgaagtccaa cttcatcttg gacccacaga gaagaacaac agtgatgaca      240

gcttttggcc agggcagcac cgccatcctg gagaagcaga tcgtggacag agccatcagc      300

gacctgcagc cggttcagca gttccaagtg gaacctgcca gtgccgccaa gtacaggctg      360

aagaatagcc gggtgagatt ccccaacgtg acagctgacg atcctctgta tagacggaag      420

gatggcggct tcgtgcctgg catggacgcc ctcagaagaa agaacgtact ggaacagaga      480

ttcttcggca agtctttcgc cgataacatc cacatccaga tgatctacag catcctggac      540

atccacaaga tcctcgctgc cgcgagcggc cacatcgtgc acctgctcaa tatcgtgaat      600

ggctcaaaag atagagactt catcggcatg ctggccgccc acgtgctgta caatgagctg      660

aacgaggagg ccaagcggag catcgccgac ttttgcaaga gtcccagact gatctactac      720

tctgctgctt tctacgagac attggacaac ggcaagagcg agcgacggtc taacgaggac      780

atcttcaaca tcctggccct gatgacctgt ctgagaaatt tcagcagcca ccacagcatc      840

gccatcaagg tgaaggacta cagcgccgct ggcctgtaca acctgcggag actgggacct      900

gacatgaaga aaatgctgga caccttctac accgaggcct tcatccagct taaccagagc      960

ttccaggacc acaacaccac aaacctgaca tgtctgttcg atatcctgaa catctctgat     1020

agcgccagac agaagcagct ggctgaggaa ttttatagat acgtggtgtt caaggaacaa     1080

aagaacttgg gattctccgt gcggaagctg agagaggaaa tgctgctgct gccagacgct     1140

gccgtgatcg ccgataagcg gtacgacacc tgcagatcca agctgtacaa cctgatggac     1200

ttcctgatcc tgagagtgta cagaaccggc agagccgaca gatgcgacaa gctgcctgag     1260

gccctgcggg ccgccctgac cgacgaggaa aaggccgtgg tgtaccacaa agaagccctg     1320

agcctgtgga acgagatgag aaccctgatc ctcgacggcc tgctgcctca gatgacacct     1380

gagaacctga gcagactgtc cggtcagaaa agaaagggcg aactgtctct ggatgacgcc     1440

atgctgaaag agtgcctgta cgagcccgga cctgtgcccg aggatgctgc ccctgaggaa     1500

gccaacgccg agtacttctg ccggatgatc tacctggcca ccctgtttat ggatggcaag     1560

gagatcaaca ccctgctgac caccctgatt agcaaattcg agaacatcgc cgccttcctg     1620

cagaccatgg aacagctgaa catcgaggcc gagctgggcc ctgaatacgc catgtttacc     1680

agaagcagag ccgtagccga gcagctgaga gtgatcaaca gcttcgccct gatgaagaag     1740

cctcaggtga atgccaagca gcagctgtac agagccgctg tcaccctgct gggaacagag     1800

gaccctgacg gcgtgaccga tgagatgctg tgcatcgacc ccgtgaccgg caagatgctg     1860

cctcctaacc agaggcatca tggcgacacc ggcttacgga acttcatcgc aaacaacgtg     1920

gtggaaagcc ggagattcca gtacttaatc cggtacagcg atcctgctca gctgcaccag     1980

ctcgccagca acaagaagct ggtcagattc gtgctgagca gcatccccga cacacagatc     2040

aacagatact atgaaacctg tggccagacc agactggccg gcagagccgc caaggtggaa     2100

ttcctgacag acatgattgc cgccatcaga ttcgaccagt ttcgggatgt caatcagaaa     2160

gagcgcggcg ccaatactca gaaagaaaga tataaggcca tgcttggcct gtaccagacc     2220

gtgctgtacc tggctgttaa aaatctggtg aacattaacg ccagatacgt gatggccttc     2280

cactgcgtgg agcgggatat gtttctgtat gacggcgagc tgacagatcc caagggcgag     2340

agcgtgtctg ctttcctggc tgtgaatgga aagaagggcg tgcagcctca gtacctgctg     2400

ctgacccagc tgtttatccg gcgggattac cttaagcgga gtgcatgcga gcagatccag     2460

cacaacatgg aaaacatctc cgaccggctg ctgcgggaat accggaacgc cgtcgcccac     2520

ctgaatgtga tagcccatct ggctgactac tctgccgaca tgagagaaat caccagctac     2580

tacggcttgt atcactacct gatgcagaga cacctcttca aaagacacgc ctggcagatc     2640

agacagcctg aaaggccaac tgaggaggaa cagaagctca tcgagcagga gcagaagcag     2700

ctggcctggg agaaggccct gtttgacaag accctgcagt accacagcta caacaaggac     2760

ctggtgaagg ctcttaacgc ccccttcgga tacaacctgg caagatacaa gaacctgtct     2820

atcgagcctc tgttcagcaa agaagccgct cctgccgccg agatcaaggc cacacacgcc     2880


<210>  536
<211>  3760
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Seq42-CTGguide3- whole nucleotide sequence from U6 promoter to SV-40 poly A

<400>  536
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattagaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg accaacacct ctgcaaaact gcaggggtct aaaaccagca gcagcagcag      300

cagcagcagc attttttcca ccacactgga ctagtggatc tctgcagccc tccttaggtc      360

ttgaaaggag tgggaattgg ctccggtgcc cgtcagtggg cagagcgcac atcgcccaca      420

gtccccgaga agttgggggg aggggtcggc aattgatccg gtgcctagag aaggtggcgc      480

ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga      540

gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc      600

agaacacagg tcacgcttaa ctaacgcgtg ccgccaccat gaacaataag agaaagacaa      660

aggccaaggc cgctggactg aagagcgtct tttttgatca gaagcaagcc gtgctgacca      720

cattcgccaa gggcaacaac tcccagatcg agaagaaagt ggtcaacagc gaggtcaaag      780

atctgagaca gcctcccgcc tttgatctgg aactgaagga gaagaccttc tatatctccg      840

gcaagaacaa cattaacaca tctagggaga accctctggc tagcgcttct ctgcctctct      900

ccaagaggca aaggattaga gccgagagga tcaagagagc tagagaagaa aatagaccct      960

accataatgt caagagggtg ggagaggacg atctgagagc caaggctgac ctcgagaaac     1020

actacttcgg caaggagtac agcgataatc tgaaaattca gattatttat aatatcctcg     1080

acatcaacaa aatcatcagc ccctatatca atgacatcgt ctactccatg aacaatctgg     1140

ctagaaacga cgagtatatc gatggaaaaa tcgacgtgat cggctccctc tcctccacca     1200

cagactactc ctccttcatg agccccaaca aggatctgga aaaggaaaaa aagttttcct     1260

tccatagaga aaactacaaa aaattcgtcg aggccagcaa gccctacatg aggtactatg     1320

gaaaggtgtt tattagagac gtgaagaaaa gcaagctctc caccggaaag ggcgagaaga     1380

ttgaggtgat gtatagatcc gacgaggaaa ttttcaccat ttttcaaatt ctgagctatg     1440

tgagacaatc catcatgcac aacgacatcg gaaacaagag cagcattctg gccatcgaaa     1500

agtaccccgc cagattcgtc ggctttctga gcgacctcct caaaaccaag acaaacgatg     1560

tcaatagaat gttcattgac aataacagcc aaacaaactt ctgggtgctc ttcagcatct     1620

tcggactgca agatcacacc agcggagccg acaagatctg tagaaatttc tacgacttcg     1680

tgatcaaggc cgacagcaaa aacctcggat tctccctcaa gaagatcaga gagctgatgc     1740

tcgatctgcc taacgccaac atgctgagag atcaccaatt cgataccgtg aggagcaagt     1800

tttataccct cctcgacttc attatctatc aacactatct cgaggagaag tccagaatcg     1860

acaacatggt ggagaagctg aggatgaccc tcaaggaaga ggaaaaggaa gtgctctacg     1920

ctgccgaggc caagattgtg tggaatgcca tcggagccaa ggtcatcaac aagctcgtgc     1980

ccatgatgaa tggcgatgct ctgaaggaga tcaagagaaa aaatagagat agaaagctcc     2040

ctcagagcgt gatcgccaca gtgcaagtga attccgacgc caatgtgttc tccggactga     2100

tctactttct gacactgttt ctcgacggca aggagatcaa cgagatggtg agcaacctca     2160

tcaccaagtt cgagaacatt gactctctgc tgcatgtcga tagagaaatc tacaagtccg     2220

acgagaagga tctggatctc gagatcgaga agctggccct ctttttcaag ggcgtggtga     2280

ggcctaatgc caagacagat accggcgccg gagagatctc caagagcttc tccatcttcc     2340

agagcgccga aaggattatc gaggaactga agttcattaa gaacgtcaca agaatggata     2400

acgagatctt ccctagcgag ggcgtgttcc tcgatgccgc taacgtgctc ggcgtcagag     2460

gcgatgactt tgactttagc aatgagtttg tcggagacga tctgcacagc gacgctaata     2520

agaagattat taacaagatc aatggcacca aggaggacag aaatctgagg aactttatta     2580

ttaataacgt cgtgaagagc agaaggtttc agtatatcgc tagacacatg aatacacact     2640

acgtcaagca gctcgccaat aacgagacac tgaatagatt cgtgctgaac aagatgggag     2700

acgccaagat catcaatagg tactacgagt ccatctccgg caataccccc aatattgagg     2760

tcagaagcca aatcgactac ctcgtcaaga gactgaggag cttcagcttc gaagacctca     2820

acgacgtcaa gcaaaaggtg agacccggca ccaatgagag catcgagaag gagaagaaaa     2880

aggccctcgt cggactgtgc ctcacaattc agtacctcgt gtataaaaat ctggtgaata     2940

tcaacgctag gtacaccacc gctttctact gtctggagag ggactccaaa ctgaaaggct     3000

ttggcgtgga cgtgtggaga gatttcgaat cctacaccgc tctgaccaat cactttatca     3060

aagaaggcta tctgcccgtg agaaaggctg aaattctgag ggccaatctg aagcatctgg     3120

actgtgaaga cggcttcaaa tattacagaa accaagtgac ccacctcaac gccattagag     3180

tcgcctataa atatatcaac gagattaaat ccgtgcacag ctacttcgcc ctctaccact     3240

acatcatgca gagacatctg tacgacagcc tccaagccaa agctaaggac tcctccggct     3300

tcgtgatcga cgctctgaag aaatccttcg agcacaagat ctacagcaaa gatctgctcc     3360

acgtgctgca ctcccccttc ggctataata ccgctagata taaaaatctg agcatcgagg     3420

ccctcttcga caagaacgaa tccagacccg aggtgaatcc cctctccacc aatgatggat     3480

cccccaaaaa aaaaaggaag gtgtaaatcc gatccaccgg atctagataa ctgatcataa     3540

tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc     3600

tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata     3660

atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc     3720

attctagttg tggtttgtcc aaactcatca atgtatctta                           3760


<210>  537
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Cas13d Seq42 direct repeat

<400>  537
gaccaacacc tctgcaaaac tgcaggggtc taaaac                                 36


<210>  538
<211>  2835
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Cas13d seq42

<400>  538
aacaataaga gaaagacaaa ggccaaggcc gctggactga agagcgtctt ttttgatcag       60

aagcaagccg tgctgaccac attcgccaag ggcaacaact cccagatcga gaagaaagtg      120

gtcaacagcg aggtcaaaga tctgagacag cctcccgcct ttgatctgga actgaaggag      180

aagaccttct atatctccgg caagaacaac attaacacat ctagggagaa ccctctggct      240

agcgcttctc tgcctctctc caagaggcaa aggattagag ccgagaggat caagagagct      300

agagaagaaa atagacccta ccataatgtc aagagggtgg gagaggacga tctgagagcc      360

aaggctgacc tcgagaaaca ctacttcggc aaggagtaca gcgataatct gaaaattcag      420

attatttata atatcctcga catcaacaaa atcatcagcc cctatatcaa tgacatcgtc      480

tactccatga acaatctggc tagaaacgac gagtatatcg atggaaaaat cgacgtgatc      540

ggctccctct cctccaccac agactactcc tccttcatga gccccaacaa ggatctggaa      600

aaggaaaaaa agttttcctt ccatagagaa aactacaaaa aattcgtcga ggccagcaag      660

ccctacatga ggtactatgg aaaggtgttt attagagacg tgaagaaaag caagctctcc      720

accggaaagg gcgagaagat tgaggtgatg tatagatccg acgaggaaat tttcaccatt      780

tttcaaattc tgagctatgt gagacaatcc atcatgcaca acgacatcgg aaacaagagc      840

agcattctgg ccatcgaaaa gtaccccgcc agattcgtcg gctttctgag cgacctcctc      900

aaaaccaaga caaacgatgt caatagaatg ttcattgaca ataacagcca aacaaacttc      960

tgggtgctct tcagcatctt cggactgcaa gatcacacca gcggagccga caagatctgt     1020

agaaatttct acgacttcgt gatcaaggcc gacagcaaaa acctcggatt ctccctcaag     1080

aagatcagag agctgatgct cgatctgcct aacgccaaca tgctgagaga tcaccaattc     1140

gataccgtga ggagcaagtt ttataccctc ctcgacttca ttatctatca acactatctc     1200

gaggagaagt ccagaatcga caacatggtg gagaagctga ggatgaccct caaggaagag     1260

gaaaaggaag tgctctacgc tgccgaggcc aagattgtgt ggaatgccat cggagccaag     1320

gtcatcaaca agctcgtgcc catgatgaat ggcgatgctc tgaaggagat caagagaaaa     1380

aatagagata gaaagctccc tcagagcgtg atcgccacag tgcaagtgaa ttccgacgcc     1440

aatgtgttct ccggactgat ctactttctg acactgtttc tcgacggcaa ggagatcaac     1500

gagatggtga gcaacctcat caccaagttc gagaacattg actctctgct gcatgtcgat     1560

agagaaatct acaagtccga cgagaaggat ctggatctcg agatcgagaa gctggccctc     1620

tttttcaagg gcgtggtgag gcctaatgcc aagacagata ccggcgccgg agagatctcc     1680

aagagcttct ccatcttcca gagcgccgaa aggattatcg aggaactgaa gttcattaag     1740

aacgtcacaa gaatggataa cgagatcttc cctagcgagg gcgtgttcct cgatgccgct     1800

aacgtgctcg gcgtcagagg cgatgacttt gactttagca atgagtttgt cggagacgat     1860

ctgcacagcg acgctaataa gaagattatt aacaagatca atggcaccaa ggaggacaga     1920

aatctgagga actttattat taataacgtc gtgaagagca gaaggtttca gtatatcgct     1980

agacacatga atacacacta cgtcaagcag ctcgccaata acgagacact gaatagattc     2040

gtgctgaaca agatgggaga cgccaagatc atcaataggt actacgagtc catctccggc     2100

aataccccca atattgaggt cagaagccaa atcgactacc tcgtcaagag actgaggagc     2160

ttcagcttcg aagacctcaa cgacgtcaag caaaaggtga gacccggcac caatgagagc     2220

atcgagaagg agaagaaaaa ggccctcgtc ggactgtgcc tcacaattca gtacctcgtg     2280

tataaaaatc tggtgaatat caacgctagg tacaccaccg ctttctactg tctggagagg     2340

gactccaaac tgaaaggctt tggcgtggac gtgtggagag atttcgaatc ctacaccgct     2400

ctgaccaatc actttatcaa agaaggctat ctgcccgtga gaaaggctga aattctgagg     2460

gccaatctga agcatctgga ctgtgaagac ggcttcaaat attacagaaa ccaagtgacc     2520

cacctcaacg ccattagagt cgcctataaa tatatcaacg agattaaatc cgtgcacagc     2580

tacttcgccc tctaccacta catcatgcag agacatctgt acgacagcct ccaagccaaa     2640

gctaaggact cctccggctt cgtgatcgac gctctgaaga aatccttcga gcacaagatc     2700

tacagcaaag atctgctcca cgtgctgcac tcccccttcg gctataatac cgctagatat     2760

aaaaatctga gcatcgaggc cctcttcgac aagaacgaat ccagacccga ggtgaatccc     2820

ctctccacca atgat                                                      2835


<210>  539
<211>  3982
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Seq212-CTGguide3- whole nucleotide sequence from U6 promoter to SV-40 poly A

<400>  539
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattagaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg tacaatagcc ctgcagtaag gcagggttct aagaccagca gcagcagcag      300

cagcagcagc attttttcca ccacactgga ctagtggatc tctgcagccc tccttaggtc      360

ttgaaaggag tgggaattgg ctccggtgcc cgtcagtggg cagagcgcac atcgcccaca      420

gtccccgaga agttgggggg aggggtcggc aattgatccg gtgcctagag aaggtggcgc      480

ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga      540

gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc      600

agaacacagg tcacgcttaa ctaacgcgtg ccgccaccat gaagaagaag caccagagcg      660

ccgccgagaa gaggcaagtg aagaagctca agaatcaaga gaaggcccag aagtacgcta      720

gcgagccttc ccccctccag agcgatacag ctggcgtgga atgctcccag aaaaagacag      780

tcgtcagcca cattgccagc tccaagacac tggccaaggc tatgggactc aaatccacac      840

tggtcatggg cgacaagctg gtcatcacca gctttgctgc tagcaaggct gtcggaggcg      900

ctggctacaa aagcgctaac attgaaaaaa tcacagatct gcaaggaagg gtcattgagg      960

agcacgaaag gatgtttagc gccgatgtcg gagagaaaaa tatcgaactg agcaagaatg     1020

actgccacac caacgtcaac aaccccgtgg tgaccaacat cggaaaggat tacatcggac     1080

tgaaatctag gctggagcaa gagtttttcg gcaagacatt cgagaatgac aatctgcatg     1140

tgcagctggc ctacaatatc ctcgacatca agaaaattct gggaacctat gtgaacaata     1200

tcatttatat cttctacaat ctgaataggg ctggcaccgg cagagatgag aggatgtatg     1260

acgacctcat cggcacactg tacgcttaca aacccatgga ggctcaacag acctatctgc     1320

tcaaaggcga caaggatatg aggaggtttg aggaggtgaa acagctgctg caaaacacct     1380

ccgcttacta tgtgtattac ggcacactgt tcgagaaggt gaaggctaag agcaagaagg     1440

aacagagggc taaggaggcc gaaatcgacg cttgtaccgc ccataactac gatgtgctga     1500

gactgctgtc cctcatgagg cagctgtgca tgcactccgt cgctggaaca gcctttaagc     1560

tggctgagtc cgctctgttc aacattgagg atgtgctcag cgccgatctg aaggaaatcc     1620

tcgatgaagc cttctccggc gccgtgaaca agctcaatga cggattcgtg cagcactccg     1680

gcaacaatct gtacgtgctc cagcagctgt accctaatga gaccatcgag agaatcgccg     1740

agaagtacta cagactcacc gtgaggaagg aggatctgaa catgggagtc aacattaaaa     1800

agctgaggga gctgatcgtg ggccaatact ttcccgaggt cctcgacaaa gaatacgacc     1860

tctccaagaa tggagacagc gtggtgacat acagaagcaa gatttatacc gtgatgaatt     1920

acattctgct gtattacctc gaggaccacg actccagcag agaaagcatg gtcgaagctc     1980

tgagacaaaa cagagagggc gatgaaggca aggaggagat ctatagacag tttgccaaga     2040

aggtgtggaa cggcgtgtcc ggactgtttg gcgtgtgtct gaacctcttc aagaccgaaa     2100

agagaaacaa gtttaggagc aaagtcgccc tccccgatgt gtccggcgct gcctatatgc     2160

tctcctccga gaacatcgac tactttgtca agatgctctt ctttgtgtgt aagtttctgg     2220

atggcaaaga aatcaacgag ctgctgtgcg ctctgatcaa caaatttgat aatattgccg     2280

atattctgga tgctgccgct caatgtggct cctccgtctg gttcgtggac agctataggt     2340

tcttcgagag atctaggagg attagcgccc agattagaat cgtgaagaac atcgcttcca     2400

aggattttaa gaaatccaag aaggattccg atgagagcta ccccgagcag ctgtatctgg     2460

atgctctggc tctgctcgga gacgtcatct ccaagtacaa gcagaataga gatggcagcg     2520

tcgtcatcga tgaccaaggc aatgccgtgc tgacagagca atacaagagg tttagatatg     2580

aatttttcga ggagatcaag agggacgaaa gcggcggcat caagtacaag aagtccggaa     2640

aacccgagta caaccatcag agaaggaatt ttattctgaa taatgtgctg aaaagcaaat     2700

ggtttttcta tgtggtgaag tacaataggc ccagcagctg cagagaactg atgaagaata     2760

aggaaattct gaggttcgtg ctgagagaca tccccgactc ccaagtgaga agatacttta     2820

aggccgtcca aggagaggaa gcttacgcta gcgccgaagc tatgaggaca agactggtcg     2880

acgctctgtc ccaatttagc gtcacagctt gtctggatga agtgggcggc atgacagaca     2940

aggaattcgc ctcccagagg gccgtcgata gcaaagaaaa actgagagcc atcatcagac     3000

tgtatctgac agtcgcctat ctgattacca agagcatggt gaaggtgaat acaaggttta     3060

gcattgcctt tagcgtgctg gagagggact actatctgct cattgacggc aagaagaaat     3120

ccagcgacta caccggagag gatatgctgg ctctgaccag aaaatttgtg ggcgaagatg     3180

ctggactgta tagagagtgg aaagagaaga acgctgaagc caaggacaaa tattttgaca     3240

aggccgaaag gaagaaggtg ctgagacaga acgataagat gatcagaaag atgcacttca     3300

caccccactc cctcaattac gtccaaaaga atctcgaaag cgtccagagc aacggactgg     3360

ccgccgtcat caaggaatat agaaatgccg tcgctcacct caatatcatc aatagactgg     3420

acgagtacat tggctccgct agggctgata gctactactc tctgtactgt tactgcctcc     3480

aaatgtatct gagcaagaac ttcagcgtgg gctacctcat caacgtgcaa aagcagctgg     3540

aggagcacca cacctacatg aaggatctca tgtggctgct caacatcccc ttcgcttaca     3600

acctcgccag atacaaaaat ctgtccaacg aaaaactctt ttacgacgag gaagccgccg     3660

ccgaaaaggc tgacaaggct gagaacgaga gaggcgaagg aagccccaag aagaaaagga     3720

aggtctaaat ccgatccacc ggatctagat aactgatcat aatcagccat accacatttg     3780

tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa     3840

tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca     3900

atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt     3960

ccaaactcat caatgtatct ta                                              3982


<210>  540
<211>  3057
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Cas13d seq212

<400>  540
aagaagaagc accagagcgc cgccgagaag aggcaagtga agaagctcaa gaatcaagag       60

aaggcccaga agtacgctag cgagccttcc cccctccaga gcgatacagc tggcgtggaa      120

tgctcccaga aaaagacagt cgtcagccac attgccagct ccaagacact ggccaaggct      180

atgggactca aatccacact ggtcatgggc gacaagctgg tcatcaccag ctttgctgct      240

agcaaggctg tcggaggcgc tggctacaaa agcgctaaca ttgaaaaaat cacagatctg      300

caaggaaggg tcattgagga gcacgaaagg atgtttagcg ccgatgtcgg agagaaaaat      360

atcgaactga gcaagaatga ctgccacacc aacgtcaaca accccgtggt gaccaacatc      420

ggaaaggatt acatcggact gaaatctagg ctggagcaag agtttttcgg caagacattc      480

gagaatgaca atctgcatgt gcagctggcc tacaatatcc tcgacatcaa gaaaattctg      540

ggaacctatg tgaacaatat catttatatc ttctacaatc tgaatagggc tggcaccggc      600

agagatgaga ggatgtatga cgacctcatc ggcacactgt acgcttacaa acccatggag      660

gctcaacaga cctatctgct caaaggcgac aaggatatga ggaggtttga ggaggtgaaa      720

cagctgctgc aaaacacctc cgcttactat gtgtattacg gcacactgtt cgagaaggtg      780

aaggctaaga gcaagaagga acagagggct aaggaggccg aaatcgacgc ttgtaccgcc      840

cataactacg atgtgctgag actgctgtcc ctcatgaggc agctgtgcat gcactccgtc      900

gctggaacag cctttaagct ggctgagtcc gctctgttca acattgagga tgtgctcagc      960

gccgatctga aggaaatcct cgatgaagcc ttctccggcg ccgtgaacaa gctcaatgac     1020

ggattcgtgc agcactccgg caacaatctg tacgtgctcc agcagctgta ccctaatgag     1080

accatcgaga gaatcgccga gaagtactac agactcaccg tgaggaagga ggatctgaac     1140

atgggagtca acattaaaaa gctgagggag ctgatcgtgg gccaatactt tcccgaggtc     1200

ctcgacaaag aatacgacct ctccaagaat ggagacagcg tggtgacata cagaagcaag     1260

atttataccg tgatgaatta cattctgctg tattacctcg aggaccacga ctccagcaga     1320

gaaagcatgg tcgaagctct gagacaaaac agagagggcg atgaaggcaa ggaggagatc     1380

tatagacagt ttgccaagaa ggtgtggaac ggcgtgtccg gactgtttgg cgtgtgtctg     1440

aacctcttca agaccgaaaa gagaaacaag tttaggagca aagtcgccct ccccgatgtg     1500

tccggcgctg cctatatgct ctcctccgag aacatcgact actttgtcaa gatgctcttc     1560

tttgtgtgta agtttctgga tggcaaagaa atcaacgagc tgctgtgcgc tctgatcaac     1620

aaatttgata atattgccga tattctggat gctgccgctc aatgtggctc ctccgtctgg     1680

ttcgtggaca gctataggtt cttcgagaga tctaggagga ttagcgccca gattagaatc     1740

gtgaagaaca tcgcttccaa ggattttaag aaatccaaga aggattccga tgagagctac     1800

cccgagcagc tgtatctgga tgctctggct ctgctcggag acgtcatctc caagtacaag     1860

cagaatagag atggcagcgt cgtcatcgat gaccaaggca atgccgtgct gacagagcaa     1920

tacaagaggt ttagatatga atttttcgag gagatcaaga gggacgaaag cggcggcatc     1980

aagtacaaga agtccggaaa acccgagtac aaccatcaga gaaggaattt tattctgaat     2040

aatgtgctga aaagcaaatg gtttttctat gtggtgaagt acaataggcc cagcagctgc     2100

agagaactga tgaagaataa ggaaattctg aggttcgtgc tgagagacat ccccgactcc     2160

caagtgagaa gatactttaa ggccgtccaa ggagaggaag cttacgctag cgccgaagct     2220

atgaggacaa gactggtcga cgctctgtcc caatttagcg tcacagcttg tctggatgaa     2280

gtgggcggca tgacagacaa ggaattcgcc tcccagaggg ccgtcgatag caaagaaaaa     2340

ctgagagcca tcatcagact gtatctgaca gtcgcctatc tgattaccaa gagcatggtg     2400

aaggtgaata caaggtttag cattgccttt agcgtgctgg agagggacta ctatctgctc     2460

attgacggca agaagaaatc cagcgactac accggagagg atatgctggc tctgaccaga     2520

aaatttgtgg gcgaagatgc tggactgtat agagagtgga aagagaagaa cgctgaagcc     2580

aaggacaaat attttgacaa ggccgaaagg aagaaggtgc tgagacagaa cgataagatg     2640

atcagaaaga tgcacttcac accccactcc ctcaattacg tccaaaagaa tctcgaaagc     2700

gtccagagca acggactggc cgccgtcatc aaggaatata gaaatgccgt cgctcacctc     2760

aatatcatca atagactgga cgagtacatt ggctccgcta gggctgatag ctactactct     2820

ctgtactgtt actgcctcca aatgtatctg agcaagaact tcagcgtggg ctacctcatc     2880

aacgtgcaaa agcagctgga ggagcaccac acctacatga aggatctcat gtggctgctc     2940

aacatcccct tcgcttacaa cctcgccaga tacaaaaatc tgtccaacga aaaactcttt     3000

tacgacgagg aagccgccgc cgaaaaggct gacaaggctg agaacgagag aggcgaa        3057


<210>  541
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  box c motif

<400>  541
rugauga                                                                  7


<210>  542
<211>  4
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  box d motif

<400>  542
cuga                                                                     4


<210>  543
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  543

Asp Arg Val Leu Lys Arg Ser Ala Glu Gly Ser Asn Pro Pro Lys Pro 
1               5                   10                  15      


Leu Lys Lys Leu Arg 
            20      


<210>  544
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  544

Leu Pro Pro Leu Glu Arg Leu Thr Leu Asp 
1               5                   10  


<210>  545
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  545

Leu Ala Leu Lys Leu Ala Gly Leu Asp Ile 
1               5                   10  


<210>  546
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  kozak sequence

<400>  546
agaaccatg                                                                9


<210>  547
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  14Pumby targeting CUG frame 3

<400>  547

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Thr Glu Gln Leu Val Gln Asp 
            20                  25                  30          


Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu His Gly Arg Pro 
        35                  40                  45              


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln 
    50                  55                  60                  


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
65                  70                  75                  80  


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
                85                  90                  95      


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg 
            100                 105                 110         


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
        115                 120                 125             


Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
    130                 135                 140                 


Tyr Val Ile Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
145                 150                 155                 160 


Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp 
                165                 170                 175     


Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro 
            180                 185                 190         


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu 
                245                 250                 255     


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
            260                 265                 270         


Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn 
        275                 280                 285             


Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
    290                 295                 300                 


Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp 
305                 310                 315                 320 


Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro 
                325                 330                 335     


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln 
            340                 345                 350         


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
        355                 360                 365             


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
    370                 375                 380                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln 
385                 390                 395                 400 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                405                 410                 415     


Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
            420                 425                 430         


Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp 
    450                 455                 460                 


Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu His Gly Arg Pro 
465                 470                 475                 480 


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln 
                485                 490                 495     


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
            500                 505                 510         


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
        515                 520                 525             


His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala 
    530                 535                 540                 


Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
545                 550                 555             


<210>  548
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  14Pumby targeting CUG frame 1

<400>  548

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Thr Glu Gln Leu Val Gln Asp 
            20                  25                  30          


Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro 
        35                  40                  45              


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln 
    50                  55                  60                  


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
65                  70                  75                  80  


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
                85                  90                  95      


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu 
            100                 105                 110         


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
        115                 120                 125             


Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn 
    130                 135                 140                 


Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
145                 150                 155                 160 


Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp 
                165                 170                 175     


Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro 
            180                 185                 190         


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln 
                245                 250                 255     


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
            260                 265                 270         


Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
        275                 280                 285             


Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
    290                 295                 300                 


Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp 
305                 310                 315                 320 


Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu His Gly Arg Pro 
                325                 330                 335     


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln 
            340                 345                 350         


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
        355                 360                 365             


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
    370                 375                 380                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg 
385                 390                 395                 400 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                405                 410                 415     


Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
            420                 425                 430         


Tyr Val Ile Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp 
    450                 455                 460                 


Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro 
465                 470                 475                 480 


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln 
                485                 490                 495     


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
            500                 505                 510         


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
        515                 520                 525             


His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala 
    530                 535                 540                 


Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
545                 550                 555             


<210>  549
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF - frame 2

<400>  549

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Tyr Val Val Arg 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Glu Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  550
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  14PUF - frame 2

<400>  550

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Ile Met Glu 
        195                 200                 205             


Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu 
    210                 215                 220                 


Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln 
225                 230                 235                 240 


Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg 
                245                 250                 255     


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            260                 265                 270         


Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser 
        275                 280                 285             


Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn 
    290                 295                 300                 


Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp 
305                 310                 315                 320 


Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro 
                325                 330                 335     


Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala 
            340                 345                 350         


Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu 
        355                 360                 365             


His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln 
    370                 375                 380                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu 
385                 390                 395                 400 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                405                 410                 415     


Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn 
            420                 425                 430         


Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His 
    450                 455                 460                 


Lys Phe Ala Ser Tyr Val Val Arg Lys Cys Val Thr His Ala Ser Arg 
465                 470                 475                 480 


Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly 
                485                 490                 495     


Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr 
            500                 505                 510         


Val Val Glu Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile 
        515                 520                 525             


Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr 
    530                 535                 540                 


Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn 
545                 550                 555                 560 


Gly Val Asp Leu Gly 
                565 


<210>  551
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  14PUF - frame 2

<400>  551

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Arg 
                245                 250                 255     


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            260                 265                 270         


Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser 
        275                 280                 285             


Tyr Val Ile Glu Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu 
    290                 295                 300                 


Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln 
305                 310                 315                 320 


Met Tyr Gly Asn Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser 
                325                 330                 335     


Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys 
            340                 345                 350         


Cys Val Lys Asp Gln Asn Gly Ser Tyr Val Val Arg Lys Cys Ile Glu 
        355                 360                 365             


Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly 
    370                 375                 380                 


Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Glu 
385                 390                 395                 400 


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
                405                 410                 415     


Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn 
            420                 425                 430         


Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His 
    450                 455                 460                 


Lys Phe Ala Ser Tyr Val Val Arg Lys Cys Val Thr His Ala Ser Arg 
465                 470                 475                 480 


Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly 
                485                 490                 495     


Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr 
            500                 505                 510         


Val Val Glu Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile 
        515                 520                 525             


Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr 
    530                 535                 540                 


Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn 
545                 550                 555                 560 


Gly Val Asp Leu Gly 
                565 


<210>  552
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  15PUF - frame 2

<400>  552

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Ile Met Glu 
        195                 200                 205             


Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu 
    210                 215                 220                 


Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln 
225                 230                 235                 240 


Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln 
                245                 250                 255     


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            260                 265                 270         


Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser 
        275                 280                 285             


Tyr Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn 
    290                 295                 300                 


Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp 
305                 310                 315                 320 


Gln Asn Gly Ser Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro 
                325                 330                 335     


Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala 
            340                 345                 350         


Leu Ser Thr His Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu 
        355                 360                 365             


His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln 
    370                 375                 380                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg 
385                 390                 395                 400 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                405                 410                 415     


Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser 
            420                 425                 430         


Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala 
        435                 440                 445             


Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser His 
    450                 455                 460                 


Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His 
465                 470                 475                 480 


Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu 
                485                 490                 495     


Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Tyr 
            500                 505                 510         


Val Val Arg Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val 
        515                 520                 525             


Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu 
    530                 535                 540                 


Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Glu Lys Met 
545                 550                 555                 560 


Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile 
                565                 570                 575     


Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile 
            580                 585                 590         


Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
        595                 600                 605             


<210>  553
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  15PUF - frame 2

<400>  553

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


His Ile Met Glu Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln 
                245                 250                 255     


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            260                 265                 270         


Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser 
        275                 280                 285             


Tyr Val Ile Arg Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu 
    290                 295                 300                 


Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln 
305                 310                 315                 320 


Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser 
                325                 330                 335     


Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys 
            340                 345                 350         


Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu 
        355                 360                 365             


Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly 
    370                 375                 380                 


Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Arg 
385                 390                 395                 400 


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
                405                 410                 415     


Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
            420                 425                 430         


Tyr Val Ile Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His 
    450                 455                 460                 


Lys Phe Ala Asn Asn Val Val Gln Lys Cys Val Thr His Ala Ser Arg 
465                 470                 475                 480 


Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly 
                485                 490                 495     


Pro His Ser Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Tyr 
            500                 505                 510         


Val Val Arg Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val 
        515                 520                 525             


Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu 
    530                 535                 540                 


Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Glu Lys Met 
545                 550                 555                 560 


Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile 
                565                 570                 575     


Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile 
            580                 585                 590         


Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
        595                 600                 605             


<210>  554
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  15PUF - frame 2

<400>  554

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser His Ile Met Glu Phe 
        275                 280                 285             


Ser Gln Asp Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu Arg 
    290                 295                 300                 


Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala 
305                 310                 315                 320 


Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys 
                325                 330                 335     


Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg 
            340                 345                 350         


Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg 
        355                 360                 365             


Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu 
    370                 375                 380                 


Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln 
385                 390                 395                 400 


Asn Gly Ser Tyr Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro Gln 
                405                 410                 415     


Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu 
            420                 425                 430         


Ser Thr His Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His 
        435                 440                 445             


Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His 
    450                 455                 460                 


Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His 
465                 470                 475                 480 


Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu 
                485                 490                 495     


Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Tyr 
            500                 505                 510         


Val Val Arg Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val 
        515                 520                 525             


Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu 
    530                 535                 540                 


Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Glu Lys Met 
545                 550                 555                 560 


Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile 
                565                 570                 575     


Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile 
            580                 585                 590         


Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
        595                 600                 605             


<210>  555
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUF - frame 2

<400>  555

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Ile Met Glu 
        195                 200                 205             


Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu 
    210                 215                 220                 


Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln 
225                 230                 235                 240 


Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu 
                245                 250                 255     


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            260                 265                 270         


Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn 
        275                 280                 285             


Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn 
    290                 295                 300                 


Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp 
305                 310                 315                 320 


Gln Asn Gly Ser Tyr Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro 
                325                 330                 335     


Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala 
            340                 345                 350         


Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu 
        355                 360                 365             


His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln 
    370                 375                 380                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln 
385                 390                 395                 400 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                405                 410                 415     


Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser 
            420                 425                 430         


Tyr Val Val Arg Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala 
        435                 440                 445             


Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala 
    450                 455                 460                 


Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Glu Lys 
465                 470                 475                 480 


Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys 
                485                 490                 495     


Ile Arg Pro His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
            500                 505                 510         


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
        515                 520                 525             


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
    530                 535                 540                 


Phe Ala Ser Tyr Val Val Arg Lys Cys Val Thr His Ala Ser Arg Thr 
545                 550                 555                 560 


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
                565                 570                 575     


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val 
            580                 585                 590         


Val Glu Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
        595                 600                 605             


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
    610                 615                 620                 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
625                 630                 635                 640 


Val Asp Leu Gly 
                


<210>  556
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUF - frame 2

<400>  556

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu 
                245                 250                 255     


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            260                 265                 270         


Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn 
        275                 280                 285             


Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu 
    290                 295                 300                 


Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln 
305                 310                 315                 320 


Met Tyr Gly Ser Tyr Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser 
                325                 330                 335     


Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys 
            340                 345                 350         


Cys Val Lys Asp Gln Asn Gly Ser Tyr Val Val Glu Lys Cys Ile Glu 
        355                 360                 365             


Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly 
    370                 375                 380                 


Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Asn Arg Val Ile Gln 
385                 390                 395                 400 


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
                405                 410                 415     


Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
            420                 425                 430         


Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His 
    450                 455                 460                 


Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg 
465                 470                 475                 480 


Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly 
                485                 490                 495     


Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr 
            500                 505                 510         


Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile 
        515                 520                 525             


Val Met His Lys Ile Arg Pro Asn Val Leu Val Leu Ser Gln His Lys 
    530                 535                 540                 


Phe Ala Ser Tyr Val Val Arg Lys Cys Val Thr His Ala Ser Arg Thr 
545                 550                 555                 560 


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
                565                 570                 575     


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val 
            580                 585                 590         


Val Glu Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
        595                 600                 605             


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
    610                 615                 620                 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
625                 630                 635                 640 


Val Asp Leu Gly 
                


<210>  557
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUF - frame 2

<400>  557

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Arg Leu 
                325                 330                 335     


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
            340                 345                 350         


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr 
        355                 360                 365             


Val Ile Glu Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
    370                 375                 380                 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
385                 390                 395                 400 


Tyr Gly Asn Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp 
                405                 410                 415     


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
            420                 425                 430         


Val Lys Asp Gln Asn Gly Ser Tyr Val Val Arg Lys Cys Ile Glu Cys 
        435                 440                 445             


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
    450                 455                 460                 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Glu Arg 
465                 470                 475                 480 


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
                485                 490                 495     


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
            500                 505                 510         


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
        515                 520                 525             


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
    530                 535                 540                 


Phe Ala Ser Tyr Val Val Arg Lys Cys Val Thr His Ala Ser Arg Thr 
545                 550                 555                 560 


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
                565                 570                 575     


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val 
            580                 585                 590         


Val Glu Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
        595                 600                 605             


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
    610                 615                 620                 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
625                 630                 635                 640 


Val Asp Leu Gly 
                


<210>  558
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  14Pumby targeting CUG frame 2

<400>  558

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Thr Glu Gln Leu Val Gln Asp 
            20                  25                  30          


Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro 
        35                  40                  45              


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln 
    50                  55                  60                  


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
65                  70                  75                  80  


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
                85                  90                  95      


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln 
            100                 105                 110         


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
        115                 120                 125             


Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
    130                 135                 140                 


Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
145                 150                 155                 160 


Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp 
                165                 170                 175     


Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu His Gly Arg Pro 
            180                 185                 190         


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg 
                245                 250                 255     


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
            260                 265                 270         


Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
        275                 280                 285             


Tyr Val Ile Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
    290                 295                 300                 


Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp 
305                 310                 315                 320 


Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro 
                325                 330                 335     


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln 
            340                 345                 350         


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
        355                 360                 365             


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
    370                 375                 380                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu 
385                 390                 395                 400 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                405                 410                 415     


Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn 
            420                 425                 430         


Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln Leu Val Gln Asp 
    450                 455                 460                 


Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro 
465                 470                 475                 480 


Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln 
                485                 490                 495     


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu 
            500                 505                 510         


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
        515                 520                 525             


His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala 
    530                 535                 540                 


Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
545                 550                 555             


<210>  559
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF - frame 3 - entire construct

<400>  559

Pro Lys Lys Lys Arg Lys Val Gly Arg Ser Arg Leu Leu Glu Asp Phe 
1               5                   10                  15      


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
            20                  25                  30          


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu Leu 
        35                  40                  45              


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
    50                  55                  60                  


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
65                  70                  75                  80  


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
                85                  90                  95      


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
            100                 105                 110         


Tyr Gly Ser Tyr Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser Asp 
        115                 120                 125             


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
    130                 135                 140                 


Val Lys Asp Gln Asn Gly Ser Tyr Val Val Glu Lys Cys Ile Glu Cys 
145                 150                 155                 160 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
                165                 170                 175     


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Asn Arg Val Ile Gln Arg 
            180                 185                 190         


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
        195                 200                 205             


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr 
    210                 215                 220                 


Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
225                 230                 235                 240 


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
                245                 250                 255     


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
            260                 265                 270         


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
        275                 280                 285             


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
    290                 295                 300                 


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
305                 310                 315                 320 


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
                325                 330                 335     


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
            340                 345                 350         


Val Asp Leu Gly Val Asp Thr Ala Asn Gly Ser Gly Gly Gly Thr Pro 
        355                 360                 365             


Lys Ala Pro Asn Leu Glu Pro Pro Leu Pro Glu Glu Glu Lys Glu Gly 
    370                 375                 380                 


Ser Asp Leu Arg Pro Val Val Ile Asp Gly Ser Asn Val Ala Met Ser 
385                 390                 395                 400 


His Gly Asn Lys Glu Val Phe Ser Cys Arg Gly Ile Leu Leu Ala Val 
                405                 410                 415     


Asn Trp Phe Leu Glu Arg Gly His Thr Asp Ile Thr Val Phe Val Pro 
            420                 425                 430         


Ser Trp Arg Lys Glu Gln Pro Arg Pro Asp Val Pro Ile Thr Asp Gln 
        435                 440                 445             


His Ile Leu Arg Glu Leu Glu Lys Lys Lys Ile Leu Val Phe Thr Pro 
    450                 455                 460                 


Ser Arg Arg Val Gly Gly Lys Arg Val Val Cys Tyr Asp Asp Arg Phe 
465                 470                 475                 480 


Ile Val Lys Leu Ala Tyr Glu Ser Asp Gly Ile Val Val Ser Asn Asp 
                485                 490                 495     


Thr Tyr Arg Asp Leu Gln Gly Glu Arg Gln Glu Trp Lys Arg Phe Ile 
            500                 505                 510         


Glu Glu Arg Leu Leu Met Tyr Ser Phe Val Asn Asp Lys Phe Met Pro 
        515                 520                 525             


Pro Asp Asp Pro Leu Gly Arg His Gly Pro Ser Leu Asp Asn Phe Leu 
    530                 535                 540                 


Arg Lys Lys Pro Leu Thr Leu Glu 
545                 550         


<210>  560
<211>  768
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  14PUF - frame 3 - entire construct

<400>  560

Pro Lys Lys Lys Arg Lys Val Gly Arg Ser Arg Leu Leu Glu Asp Phe 
1               5                   10                  15      


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
            20                  25                  30          


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu Leu 
        35                  40                  45              


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
    50                  55                  60                  


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
65                  70                  75                  80  


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
                85                  90                  95      


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
            100                 105                 110         


Tyr Gly Ser Tyr Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser Asp 
        115                 120                 125             


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
    130                 135                 140                 


Val Lys Asp Gln Asn Gly Ser Tyr Val Val Glu Lys Cys Ile Glu Cys 
145                 150                 155                 160 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
                165                 170                 175     


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Asn Arg Val Ile Gln Arg 
            180                 185                 190         


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
        195                 200                 205             


Leu His Gln His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg 
    210                 215                 220                 


Phe Ile Arg Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu 
225                 230                 235                 240 


Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val 
                245                 250                 255     


Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu Phe Gly Ser Leu Glu 
            260                 265                 270         


Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu 
        275                 280                 285             


Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln Lys Ala Leu Glu Phe 
    290                 295                 300                 


Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His 
305                 310                 315                 320 


Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser Tyr Val Val Arg Lys 
                325                 330                 335     


Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala 
            340                 345                 350         


Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg 
        355                 360                 365             


Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro 
    370                 375                 380                 


Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln 
385                 390                 395                 400 


Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu 
                405                 410                 415     


Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly His Thr Glu Gln Leu 
            420                 425                 430         


Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu His 
        435                 440                 445             


Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn 
    450                 455                 460                 


Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys 
465                 470                 475                 480 


Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu 
                485                 490                 495     


Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met 
            500                 505                 510         


Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala 
        515                 520                 525             


Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile 
    530                 535                 540                 


Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu 
545                 550                 555                 560 


Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Val Asp Thr Ala 
                565                 570                 575     


Asn Gly Ser Gly Gly Gly Thr Pro Lys Ala Pro Asn Leu Glu Pro Pro 
            580                 585                 590         


Leu Pro Glu Glu Glu Lys Glu Gly Ser Asp Leu Arg Pro Val Val Ile 
        595                 600                 605             


Asp Gly Ser Asn Val Ala Met Ser His Gly Asn Lys Glu Val Phe Ser 
    610                 615                 620                 


Cys Arg Gly Ile Leu Leu Ala Val Asn Trp Phe Leu Glu Arg Gly His 
625                 630                 635                 640 


Thr Asp Ile Thr Val Phe Val Pro Ser Trp Arg Lys Glu Gln Pro Arg 
                645                 650                 655     


Pro Asp Val Pro Ile Thr Asp Gln His Ile Leu Arg Glu Leu Glu Lys 
            660                 665                 670         


Lys Lys Ile Leu Val Phe Thr Pro Ser Arg Arg Val Gly Gly Lys Arg 
        675                 680                 685             


Val Val Cys Tyr Asp Asp Arg Phe Ile Val Lys Leu Ala Tyr Glu Ser 
    690                 695                 700                 


Asp Gly Ile Val Val Ser Asn Asp Thr Tyr Arg Asp Leu Gln Gly Glu 
705                 710                 715                 720 


Arg Gln Glu Trp Lys Arg Phe Ile Glu Glu Arg Leu Leu Met Tyr Ser 
                725                 730                 735     


Phe Val Asn Asp Lys Phe Met Pro Pro Asp Asp Pro Leu Gly Arg His 
            740                 745                 750         


Gly Pro Ser Leu Asp Asn Phe Leu Arg Lys Lys Pro Leu Thr Leu Glu 
        755                 760                 765             


<210>  561
<211>  768
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  14PUF - frame 3 - entire construct

<400>  561

Pro Lys Lys Lys Arg Lys Val Gly Arg Ser Arg Leu Leu Glu Asp Phe 
1               5                   10                  15      


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
            20                  25                  30          


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Glu Leu 
        35                  40                  45              


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
    50                  55                  60                  


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
65                  70                  75                  80  


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
                85                  90                  95      


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
            100                 105                 110         


Tyr Gly Ser Tyr Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser Asp 
        115                 120                 125             


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
    130                 135                 140                 


Val Lys Asp Gln Asn Gly Ser Tyr Val Val Glu Lys Cys Ile Glu Cys 
145                 150                 155                 160 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
                165                 170                 175     


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Asn Arg Val Ile Gln Arg 
            180                 185                 190         


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
        195                 200                 205             


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr 
    210                 215                 220                 


Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
225                 230                 235                 240 


Ile Val Ala Glu Ile Arg Gly His Ile Met Glu Phe Ser Gln Asp Gln 
                245                 250                 255     


His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro Ala 
            260                 265                 270         


Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu 
        275                 280                 285             


Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe 
    290                 295                 300                 


Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His 
305                 310                 315                 320 


Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg Lys 
                325                 330                 335     


Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu 
            340                 345                 350         


Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser Tyr 
        355                 360                 365             


Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe 
    370                 375                 380                 


Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro 
385                 390                 395                 400 


Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp 
                405                 410                 415     


Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu 
            420                 425                 430         


Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu His 
        435                 440                 445             


Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn 
    450                 455                 460                 


Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys 
465                 470                 475                 480 


Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu 
                485                 490                 495     


Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met 
            500                 505                 510         


Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala 
        515                 520                 525             


Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile 
    530                 535                 540                 


Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu 
545                 550                 555                 560 


Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Val Asp Thr Ala 
                565                 570                 575     


Asn Gly Ser Gly Gly Gly Thr Pro Lys Ala Pro Asn Leu Glu Pro Pro 
            580                 585                 590         


Leu Pro Glu Glu Glu Lys Glu Gly Ser Asp Leu Arg Pro Val Val Ile 
        595                 600                 605             


Asp Gly Ser Asn Val Ala Met Ser His Gly Asn Lys Glu Val Phe Ser 
    610                 615                 620                 


Cys Arg Gly Ile Leu Leu Ala Val Asn Trp Phe Leu Glu Arg Gly His 
625                 630                 635                 640 


Thr Asp Ile Thr Val Phe Val Pro Ser Trp Arg Lys Glu Gln Pro Arg 
                645                 650                 655     


Pro Asp Val Pro Ile Thr Asp Gln His Ile Leu Arg Glu Leu Glu Lys 
            660                 665                 670         


Lys Lys Ile Leu Val Phe Thr Pro Ser Arg Arg Val Gly Gly Lys Arg 
        675                 680                 685             


Val Val Cys Tyr Asp Asp Arg Phe Ile Val Lys Leu Ala Tyr Glu Ser 
    690                 695                 700                 


Asp Gly Ile Val Val Ser Asn Asp Thr Tyr Arg Asp Leu Gln Gly Glu 
705                 710                 715                 720 


Arg Gln Glu Trp Lys Arg Phe Ile Glu Glu Arg Leu Leu Met Tyr Ser 
                725                 730                 735     


Phe Val Asn Asp Lys Phe Met Pro Pro Asp Asp Pro Leu Gly Arg His 
            740                 745                 750         


Gly Pro Ser Leu Asp Asn Phe Leu Arg Lys Lys Pro Leu Thr Leu Glu 
        755                 760                 765             


<210>  562
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  15PUF - frame 3 - entire construct

<400>  562

Pro Lys Lys Lys Arg Lys Val Gly Arg Ser Arg Leu Leu Glu Asp Phe 
1               5                   10                  15      


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
            20                  25                  30          


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Arg Leu 
        35                  40                  45              


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
    50                  55                  60                  


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr 
65                  70                  75                  80  


Val Ile Glu Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
                85                  90                  95      


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
            100                 105                 110         


Tyr Gly Asn Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp 
        115                 120                 125             


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
    130                 135                 140                 


Val Lys Asp Gln Asn Gly Ser Tyr Val Val Arg Lys Cys Ile Glu Cys 
145                 150                 155                 160 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
                165                 170                 175     


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Glu Arg 
            180                 185                 190         


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
        195                 200                 205             


Leu His Gln His Ile Met Glu Phe Ser Gln Asp Gln His Gly Asn Arg 
    210                 215                 220                 


Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu 
225                 230                 235                 240 


Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val 
                245                 250                 255     


Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu Phe Gly Ser Leu Glu 
            260                 265                 270         


Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu 
        275                 280                 285             


Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe 
    290                 295                 300                 


Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His 
305                 310                 315                 320 


Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys 
                325                 330                 335     


Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala 
            340                 345                 350         


Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg 
        355                 360                 365             


Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro 
    370                 375                 380                 


Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln 
385                 390                 395                 400 


Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu His Gly Arg Pro Glu 
                405                 410                 415     


Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu 
            420                 425                 430         


Ser Gln His Lys Phe Ala Asn Asn Val Val Gln Lys Cys Val Thr His 
        435                 440                 445             


Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met 
    450                 455                 460                 


Asn Asp Gly Pro His Ser His Thr Glu Gln Leu Val Gln Asp Gln Tyr 
465                 470                 475                 480 


Gly Ser Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp 
                485                 490                 495     


Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser 
            500                 505                 510         


Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala 
        515                 520                 525             


Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn 
    530                 535                 540                 


Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala 
545                 550                 555                 560 


Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg 
                565                 570                 575     


Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys 
            580                 585                 590         


Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met 
        595                 600                 605             


Lys Asn Gly Val Asp Leu Gly Val Asp Thr Ala Asn Gly Ser Gly Gly 
    610                 615                 620                 


Gly Thr Pro Lys Ala Pro Asn Leu Glu Pro Pro Leu Pro Glu Glu Glu 
625                 630                 635                 640 


Lys Glu Gly Ser Asp Leu Arg Pro Val Val Ile Asp Gly Ser Asn Val 
                645                 650                 655     


Ala Met Ser His Gly Asn Lys Glu Val Phe Ser Cys Arg Gly Ile Leu 
            660                 665                 670         


Leu Ala Val Asn Trp Phe Leu Glu Arg Gly His Thr Asp Ile Thr Val 
        675                 680                 685             


Phe Val Pro Ser Trp Arg Lys Glu Gln Pro Arg Pro Asp Val Pro Ile 
    690                 695                 700                 


Thr Asp Gln His Ile Leu Arg Glu Leu Glu Lys Lys Lys Ile Leu Val 
705                 710                 715                 720 


Phe Thr Pro Ser Arg Arg Val Gly Gly Lys Arg Val Val Cys Tyr Asp 
                725                 730                 735     


Asp Arg Phe Ile Val Lys Leu Ala Tyr Glu Ser Asp Gly Ile Val Val 
            740                 745                 750         


Ser Asn Asp Thr Tyr Arg Asp Leu Gln Gly Glu Arg Gln Glu Trp Lys 
        755                 760                 765             


Arg Phe Ile Glu Glu Arg Leu Leu Met Tyr Ser Phe Val Asn Asp Lys 
    770                 775                 780                 


Phe Met Pro Pro Asp Asp Pro Leu Gly Arg His Gly Pro Ser Leu Asp 
785                 790                 795                 800 


Asn Phe Leu Arg Lys Lys Pro Leu Thr Leu Glu 
                805                 810     


<210>  563
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  15PUF - frame 3 - entire construct

<400>  563

Pro Lys Lys Lys Arg Lys Val Gly Arg Ser Arg Leu Leu Glu Asp Phe 
1               5                   10                  15      


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
            20                  25                  30          


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Arg Leu 
        35                  40                  45              


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
    50                  55                  60                  


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr 
65                  70                  75                  80  


Val Ile Glu Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
                85                  90                  95      


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
            100                 105                 110         


Tyr Gly Asn Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp 
        115                 120                 125             


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
    130                 135                 140                 


Val Lys Asp Gln Asn Gly Ser Tyr Val Val Arg Lys Cys Ile Glu Cys 
145                 150                 155                 160 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
                165                 170                 175     


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Glu Arg 
            180                 185                 190         


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
        195                 200                 205             


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
    210                 215                 220                 


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
225                 230                 235                 240 


Ile Val Ala Glu Ile Arg Gly His Ile Met Glu Phe Ser Gln Asp Gln 
                245                 250                 255     


His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu Arg Ala Thr Pro Ala 
            260                 265                 270         


Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu 
        275                 280                 285             


Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu Phe 
    290                 295                 300                 


Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His 
305                 310                 315                 320 


Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Asn Arg Val Ile Gln Lys 
                325                 330                 335     


Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu 
            340                 345                 350         


Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser Tyr 
        355                 360                 365             


Val Val Arg Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe 
    370                 375                 380                 


Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro 
385                 390                 395                 400 


Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro Asp 
                405                 410                 415     


Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu 
            420                 425                 430         


Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His 
        435                 440                 445             


Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn 
    450                 455                 460                 


Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Tyr Val Val Arg Lys 
465                 470                 475                 480 


Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu 
                485                 490                 495     


Val Cys Thr Met Asn Asp Gly Pro His Ser Asn Val Leu Val Leu Ser 
            500                 505                 510         


Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala 
        515                 520                 525             


Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn 
    530                 535                 540                 


Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala 
545                 550                 555                 560 


Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg 
                565                 570                 575     


Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys 
            580                 585                 590         


Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met 
        595                 600                 605             


Lys Asn Gly Val Asp Leu Gly Val Asp Thr Ala Asn Gly Ser Gly Gly 
    610                 615                 620                 


Gly Thr Pro Lys Ala Pro Asn Leu Glu Pro Pro Leu Pro Glu Glu Glu 
625                 630                 635                 640 


Lys Glu Gly Ser Asp Leu Arg Pro Val Val Ile Asp Gly Ser Asn Val 
                645                 650                 655     


Ala Met Ser His Gly Asn Lys Glu Val Phe Ser Cys Arg Gly Ile Leu 
            660                 665                 670         


Leu Ala Val Asn Trp Phe Leu Glu Arg Gly His Thr Asp Ile Thr Val 
        675                 680                 685             


Phe Val Pro Ser Trp Arg Lys Glu Gln Pro Arg Pro Asp Val Pro Ile 
    690                 695                 700                 


Thr Asp Gln His Ile Leu Arg Glu Leu Glu Lys Lys Lys Ile Leu Val 
705                 710                 715                 720 


Phe Thr Pro Ser Arg Arg Val Gly Gly Lys Arg Val Val Cys Tyr Asp 
                725                 730                 735     


Asp Arg Phe Ile Val Lys Leu Ala Tyr Glu Ser Asp Gly Ile Val Val 
            740                 745                 750         


Ser Asn Asp Thr Tyr Arg Asp Leu Gln Gly Glu Arg Gln Glu Trp Lys 
        755                 760                 765             


Arg Phe Ile Glu Glu Arg Leu Leu Met Tyr Ser Phe Val Asn Asp Lys 
    770                 775                 780                 


Phe Met Pro Pro Asp Asp Pro Leu Gly Arg His Gly Pro Ser Leu Asp 
785                 790                 795                 800 


Asn Phe Leu Arg Lys Lys Pro Leu Thr Leu Glu 
                805                 810     


<210>  564
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUF - frame 3 - entire construct

<400>  564

Pro Lys Lys Lys Arg Lys Val Gly Arg Ser Arg Leu Leu Glu Asp Phe 
1               5                   10                  15      


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
            20                  25                  30          


Ile Met Glu Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln Leu 
        35                  40                  45              


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
    50                  55                  60                  


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr 
65                  70                  75                  80  


Val Ile Arg Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
                85                  90                  95      


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
            100                 105                 110         


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
        115                 120                 125             


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
    130                 135                 140                 


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
145                 150                 155                 160 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
                165                 170                 175     


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Arg Arg 
            180                 185                 190         


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
        195                 200                 205             


Leu His Gln His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg 
    210                 215                 220                 


Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu 
225                 230                 235                 240 


Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val 
                245                 250                 255     


Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu 
            260                 265                 270         


Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu 
        275                 280                 285             


Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg Lys Ala Leu Glu Phe 
    290                 295                 300                 


Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His 
305                 310                 315                 320 


Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser Tyr Val Val Glu Lys 
                325                 330                 335     


Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala 
            340                 345                 350         


Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Asn Arg 
        355                 360                 365             


Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro 
    370                 375                 380                 


Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln 
385                 390                 395                 400 


Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu 
                405                 410                 415     


Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu 
            420                 425                 430         


Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His 
        435                 440                 445             


Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met 
    450                 455                 460                 


Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr 
465                 470                 475                 480 


Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln 
                485                 490                 495     


Arg Lys Ile Val Met His Lys Ile Arg Pro His Thr Glu Gln Leu Val 
            500                 505                 510         


Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu His Gly 
        515                 520                 525             


Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val 
    530                 535                 540                 


Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys 
545                 550                 555                 560 


Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val 
                565                 570                 575     


Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys 
            580                 585                 590         


Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu 
        595                 600                 605             


Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala 
    610                 615                 620                 


Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu 
625                 630                 635                 640 


Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Val Asp Thr Ala Asn 
                645                 650                 655     


Gly Ser Gly Gly Gly Thr Pro Lys Ala Pro Asn Leu Glu Pro Pro Leu 
            660                 665                 670         


Pro Glu Glu Glu Lys Glu Gly Ser Asp Leu Arg Pro Val Val Ile Asp 
        675                 680                 685             


Gly Ser Asn Val Ala Met Ser His Gly Asn Lys Glu Val Phe Ser Cys 
    690                 695                 700                 


Arg Gly Ile Leu Leu Ala Val Asn Trp Phe Leu Glu Arg Gly His Thr 
705                 710                 715                 720 


Asp Ile Thr Val Phe Val Pro Ser Trp Arg Lys Glu Gln Pro Arg Pro 
                725                 730                 735     


Asp Val Pro Ile Thr Asp Gln His Ile Leu Arg Glu Leu Glu Lys Lys 
            740                 745                 750         


Lys Ile Leu Val Phe Thr Pro Ser Arg Arg Val Gly Gly Lys Arg Val 
        755                 760                 765             


Val Cys Tyr Asp Asp Arg Phe Ile Val Lys Leu Ala Tyr Glu Ser Asp 
    770                 775                 780                 


Gly Ile Val Val Ser Asn Asp Thr Tyr Arg Asp Leu Gln Gly Glu Arg 
785                 790                 795                 800 


Gln Glu Trp Lys Arg Phe Ile Glu Glu Arg Leu Leu Met Tyr Ser Phe 
                805                 810                 815     


Val Asn Asp Lys Phe Met Pro Pro Asp Asp Pro Leu Gly Arg His Gly 
            820                 825                 830         


Pro Ser Leu Asp Asn Phe Leu Arg Lys Lys Pro Leu Thr Leu Glu 
        835                 840                 845         


<210>  565
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUF - frame 3 - entire construct

<400>  565

Pro Lys Lys Lys Arg Lys Val Gly Arg Ser Arg Leu Leu Glu Asp Phe 
1               5                   10                  15      


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
            20                  25                  30          


Ile Met Glu Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln Leu 
        35                  40                  45              


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
    50                  55                  60                  


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr 
65                  70                  75                  80  


Val Ile Arg Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
                85                  90                  95      


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
            100                 105                 110         


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
        115                 120                 125             


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
    130                 135                 140                 


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
145                 150                 155                 160 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
                165                 170                 175     


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Arg Arg 
            180                 185                 190         


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
        195                 200                 205             


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr 
    210                 215                 220                 


Val Ile Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
225                 230                 235                 240 


Ile Val Ala Glu Ile Arg Gly His Ile Met Glu Phe Ser Gln Asp Gln 
                245                 250                 255     


His Gly Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala 
            260                 265                 270         


Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu 
        275                 280                 285             


Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu Phe 
    290                 295                 300                 


Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His 
305                 310                 315                 320 


Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys 
                325                 330                 335     


Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu 
            340                 345                 350         


Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His 
        355                 360                 365             


Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe 
    370                 375                 380                 


Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro 
385                 390                 395                 400 


Tyr Gly Ser Arg Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro Asp 
                405                 410                 415     


Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu 
            420                 425                 430         


Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Glu His Val Leu Glu His 
        435                 440                 445             


Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn 
    450                 455                 460                 


Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln Lys 
465                 470                 475                 480 


Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu 
                485                 490                 495     


Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met 
            500                 505                 510         


Lys Asp Gln Tyr Ala Ser Tyr Val Val Arg Lys Met Ile Asp Val Ala 
        515                 520                 525             


Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro Asn Val 
    530                 535                 540                 


Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys 
545                 550                 555                 560 


Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val 
                565                 570                 575     


Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys 
            580                 585                 590         


Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu 
        595                 600                 605             


Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala 
    610                 615                 620                 


Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu 
625                 630                 635                 640 


Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Val Asp Thr Ala Asn 
                645                 650                 655     


Gly Ser Gly Gly Gly Thr Pro Lys Ala Pro Asn Leu Glu Pro Pro Leu 
            660                 665                 670         


Pro Glu Glu Glu Lys Glu Gly Ser Asp Leu Arg Pro Val Val Ile Asp 
        675                 680                 685             


Gly Ser Asn Val Ala Met Ser His Gly Asn Lys Glu Val Phe Ser Cys 
    690                 695                 700                 


Arg Gly Ile Leu Leu Ala Val Asn Trp Phe Leu Glu Arg Gly His Thr 
705                 710                 715                 720 


Asp Ile Thr Val Phe Val Pro Ser Trp Arg Lys Glu Gln Pro Arg Pro 
                725                 730                 735     


Asp Val Pro Ile Thr Asp Gln His Ile Leu Arg Glu Leu Glu Lys Lys 
            740                 745                 750         


Lys Ile Leu Val Phe Thr Pro Ser Arg Arg Val Gly Gly Lys Arg Val 
        755                 760                 765             


Val Cys Tyr Asp Asp Arg Phe Ile Val Lys Leu Ala Tyr Glu Ser Asp 
    770                 775                 780                 


Gly Ile Val Val Ser Asn Asp Thr Tyr Arg Asp Leu Gln Gly Glu Arg 
785                 790                 795                 800 


Gln Glu Trp Lys Arg Phe Ile Glu Glu Arg Leu Leu Met Tyr Ser Phe 
                805                 810                 815     


Val Asn Asp Lys Phe Met Pro Pro Asp Asp Pro Leu Gly Arg His Gly 
            820                 825                 830         


Pro Ser Leu Asp Asn Phe Leu Arg Lys Lys Pro Leu Thr Leu Glu 
        835                 840                 845         


<210>  566
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUF - frame 3 - entire construct

<400>  566

Pro Lys Lys Lys Arg Lys Val Gly Arg Ser Arg Leu Leu Glu Asp Phe 
1               5                   10                  15      


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
            20                  25                  30          


Ile Met Glu Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln Leu 
        35                  40                  45              


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
    50                  55                  60                  


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr 
65                  70                  75                  80  


Val Ile Arg Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
                85                  90                  95      


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
            100                 105                 110         


Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp 
        115                 120                 125             


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
    130                 135                 140                 


Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys 
145                 150                 155                 160 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
                165                 170                 175     


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Arg Arg 
            180                 185                 190         


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
        195                 200                 205             


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr 
    210                 215                 220                 


Val Ile Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
225                 230                 235                 240 


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
                245                 250                 255     


Phe Ala Asn Asn Val Val Gln Lys Cys Val Thr His Ala Ser Arg Thr 
            260                 265                 270         


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
        275                 280                 285             


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr Val 
    290                 295                 300                 


Val Arg Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
305                 310                 315                 320 


Met His Lys Ile Arg Pro His Ile Met Glu Phe Ser Gln Asp Gln His 
                325                 330                 335     


Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu 
            340                 345                 350         


Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met 
        355                 360                 365             


Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly 
    370                 375                 380                 


Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val 
385                 390                 395                 400 


Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg Lys Ala 
                405                 410                 415     


Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu 
            420                 425                 430         


Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser Tyr Val 
        435                 440                 445             


Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile 
    450                 455                 460                 


Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr 
465                 470                 475                 480 


Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln 
                485                 490                 495     


Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val 
            500                 505                 510         


Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu His Gly 
        515                 520                 525             


Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val 
    530                 535                 540                 


Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys 
545                 550                 555                 560 


Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val 
                565                 570                 575     


Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys 
            580                 585                 590         


Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu 
        595                 600                 605             


Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala 
    610                 615                 620                 


Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu 
625                 630                 635                 640 


Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Val Asp Thr Ala Asn 
                645                 650                 655     


Gly Ser Gly Gly Gly Thr Pro Lys Ala Pro Asn Leu Glu Pro Pro Leu 
            660                 665                 670         


Pro Glu Glu Glu Lys Glu Gly Ser Asp Leu Arg Pro Val Val Ile Asp 
        675                 680                 685             


Gly Ser Asn Val Ala Met Ser His Gly Asn Lys Glu Val Phe Ser Cys 
    690                 695                 700                 


Arg Gly Ile Leu Leu Ala Val Asn Trp Phe Leu Glu Arg Gly His Thr 
705                 710                 715                 720 


Asp Ile Thr Val Phe Val Pro Ser Trp Arg Lys Glu Gln Pro Arg Pro 
                725                 730                 735     


Asp Val Pro Ile Thr Asp Gln His Ile Leu Arg Glu Leu Glu Lys Lys 
            740                 745                 750         


Lys Ile Leu Val Phe Thr Pro Ser Arg Arg Val Gly Gly Lys Arg Val 
        755                 760                 765             


Val Cys Tyr Asp Asp Arg Phe Ile Val Lys Leu Ala Tyr Glu Ser Asp 
    770                 775                 780                 


Gly Ile Val Val Ser Asn Asp Thr Tyr Arg Asp Leu Gln Gly Glu Arg 
785                 790                 795                 800 


Gln Glu Trp Lys Arg Phe Ile Glu Glu Arg Leu Leu Met Tyr Ser Phe 
                805                 810                 815     


Val Asn Asp Lys Phe Met Pro Pro Asp Asp Pro Leu Gly Arg His Gly 
            820                 825                 830         


Pro Ser Leu Asp Asn Phe Leu Arg Lys Lys Pro Leu Thr Leu Glu 
        835                 840                 845         


<210>  567
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  15PUF - frame 3 - entire construct

<400>  567

Pro Lys Lys Lys Arg Lys Val Gly Arg Ser Arg Leu Leu Glu Asp Phe 
1               5                   10                  15      


Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His 
            20                  25                  30          


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Arg Leu 
        35                  40                  45              


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
    50                  55                  60                  


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Tyr 
65                  70                  75                  80  


Val Ile Glu Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
                85                  90                  95      


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
            100                 105                 110         


Tyr Gly Asn Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp 
        115                 120                 125             


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
    130                 135                 140                 


Val Lys Asp Gln Asn Gly Ser Tyr Val Val Arg Lys Cys Ile Glu Cys 
145                 150                 155                 160 


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
                165                 170                 175     


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val Ile Glu Arg 
            180                 185                 190         


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
        195                 200                 205             


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr 
    210                 215                 220                 


Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
225                 230                 235                 240 


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
                245                 250                 255     


Phe Ala Ser Tyr Val Val Arg Lys Cys Val Thr His Ala Ser Arg Thr 
            260                 265                 270         


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
        275                 280                 285             


His Ser His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe 
    290                 295                 300                 


Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val 
305                 310                 315                 320 


Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe 
                325                 330                 335     


Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln 
            340                 345                 350         


Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala 
        355                 360                 365             


Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg Lys Ala Leu Glu Phe Ile 
    370                 375                 380                 


Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val 
385                 390                 395                 400 


Leu Lys Cys Val Lys Asp Gln Asn Gly Ser Tyr Val Val Glu Lys Cys 
                405                 410                 415     


Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe 
            420                 425                 430         


Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Asn Arg Val 
        435                 440                 445             


Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile 
    450                 455                 460                 


Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr 
465                 470                 475                 480 


Gly Ser Tyr Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp 
                485                 490                 495     


Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser 
            500                 505                 510         


Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala 
        515                 520                 525             


Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn 
    530                 535                 540                 


Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala 
545                 550                 555                 560 


Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg 
                565                 570                 575     


Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys 
            580                 585                 590         


Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met 
        595                 600                 605             


Lys Asn Gly Val Asp Leu Gly Val Asp Thr Ala Asn Gly Ser Gly Gly 
    610                 615                 620                 


Gly Thr Pro Lys Ala Pro Asn Leu Glu Pro Pro Leu Pro Glu Glu Glu 
625                 630                 635                 640 


Lys Glu Gly Ser Asp Leu Arg Pro Val Val Ile Asp Gly Ser Asn Val 
                645                 650                 655     


Ala Met Ser His Gly Asn Lys Glu Val Phe Ser Cys Arg Gly Ile Leu 
            660                 665                 670         


Leu Ala Val Asn Trp Phe Leu Glu Arg Gly His Thr Asp Ile Thr Val 
        675                 680                 685             


Phe Val Pro Ser Trp Arg Lys Glu Gln Pro Arg Pro Asp Val Pro Ile 
    690                 695                 700                 


Thr Asp Gln His Ile Leu Arg Glu Leu Glu Lys Lys Lys Ile Leu Val 
705                 710                 715                 720 


Phe Thr Pro Ser Arg Arg Val Gly Gly Lys Arg Val Val Cys Tyr Asp 
                725                 730                 735     


Asp Arg Phe Ile Val Lys Leu Ala Tyr Glu Ser Asp Gly Ile Val Val 
            740                 745                 750         


Ser Asn Asp Thr Tyr Arg Asp Leu Gln Gly Glu Arg Gln Glu Trp Lys 
        755                 760                 765             


Arg Phe Ile Glu Glu Arg Leu Leu Met Tyr Ser Phe Val Asn Asp Lys 
    770                 775                 780                 


Phe Met Pro Pro Asp Asp Pro Leu Gly Arg His Gly Pro Ser Leu Asp 
785                 790                 795                 800 


Asn Phe Leu Arg Lys Lys Pro Leu Thr Leu Glu 
                805                 810     


<210>  568
<211>  1060
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Human desmin promoter full

<400>  568
taccccctgc cccccacagc tcctctcctg tgccttgttt cccagccatg cgttctcctc       60

tataaatacc cgctctggta tttggggttg gcagctgttg ctgccaggga gatggttggg      120

ttgacatgcg gctcctgaca aaacacaaac ccctggtgtg tgtgggcgtg ggtggtgtga      180

gtagggggat gaatcaggga gggggcaggg gacccagggg gcaggagcca cacaaagtct      240

gtgcgggggt gggagcgcac atagcaattg gaaactgaaa gcttatcaga ccctttctgg      300

aaatcagccc actgtttata aacttgaggc cccaccctcg acagtaccgg ggaggaagag      360

ggcctgcact agtccagagg gaaactgagg ctcagggcca gctcgcccat agacatacat      420

ggcaggcagg ctttggccag gatccctccg cctgccaggc gtctccctgc cctcccttcc      480

tgcctagaga cccccaccct caagcctggc tggtctttgc ctgagaccca aacctcttcg      540

acttcaagag aatatttagg aacaaggtgg tttagggcct ttcctgggaa caggccttga      600

ccctttaaga aatgacccaa agtctctcct tgaccaaaaa ggggaccctc aaactaaagg      660

gaagcctctc ttctgctgtc tcccctgacc ccactccccc ccaccccagg acgaggagat      720

aaccagggct gaaagaggcc cgcctggggg ctgcagacat gcttgctgcc tgccctggcg      780

aaggattggc aggcttgccc gtcacaggac ccccgctggc tgactcaggg gcgcaggcct      840

tttgcggggg agctggcctc cccgccccca cggccacggg ccgccctttc ctggcaggac      900

agcgggatct tgcagctgtc aggggagggg aggcgggggc tgatgtcagg agggatacaa      960

atagtgccga cggctggggg ccctgtctcc cctcgccgca tccactctcc ggccggccgc     1020

ctgcccgccg cctcctccgt gcgcccgcca gcctcgcccg                           1060


<210>  569
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  human desmin promoter truncated

<400>  569
acccatgcct cctcaggtac cccctgcccc ccacagctcc tctcctgtgc cttgtttccc       60

agccatgcgt tctcctctat aaatacccgc tctggtattt ggggttggca gctgttgctg      120

ccagggagat ggttgggttg acatgcggct cctgacaaaa cacaaacccc tggtgtgtgt      180

gggcgtgggt ggtgtgagta gggggatgaa tcagggaggg ggcaggggac ccagggggca      240

ggagccacac aaagtctgtg cgggggtggg agcgcacata gcaattggaa actgaaagct      300

tatcagaccc tttctggaaa tcagcccact gtttataaac ttgaggcccc accctcgaga      360

taaccagggc tgaaagaggc ccgcctgggg gctgcagaca tgcttgctgc ctgccctggc      420

gaaggattgg caggcttgcc cgtcacagga cccccgctgg ctgactcagg ggcgcaggcc      480

ttttgcgggg gagctggcct ccccgccccc acggccacgg gccgcccttt cctggcagga      540

cagcgggatc ttgcagctgt caggggaggg gaggcggggg ctgatgtcag gagggatata      600

aatagtgccg acggctgggg gccctgtctc ccctcgccgc atccactctc cggccggccg      660

cctgcccgcc gcctcctccg tgcgcccgcc agcctcgccc gcgccgtc                   708


<210>  570
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF

<400>  570

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  571
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SV-40 NLS

<400>  571

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  572
<211>  1019
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cas13d Seq212

<400>  572

Lys Lys Lys His Gln Ser Ala Ala Glu Lys Arg Gln Val Lys Lys Leu 
1               5                   10                  15      


Lys Asn Gln Glu Lys Ala Gln Lys Tyr Ala Ser Glu Pro Ser Pro Leu 
            20                  25                  30          


Gln Ser Asp Thr Ala Gly Val Glu Cys Ser Gln Lys Lys Thr Val Val 
        35                  40                  45              


Ser His Ile Ala Ser Ser Lys Thr Leu Ala Lys Ala Met Gly Leu Lys 
    50                  55                  60                  


Ser Thr Leu Val Met Gly Asp Lys Leu Val Ile Thr Ser Phe Ala Ala 
65                  70                  75                  80  


Ser Lys Ala Val Gly Gly Ala Gly Tyr Lys Ser Ala Asn Ile Glu Lys 
                85                  90                  95      


Ile Thr Asp Leu Gln Gly Arg Val Ile Glu Glu His Glu Arg Met Phe 
            100                 105                 110         


Ser Ala Asp Val Gly Glu Lys Asn Ile Glu Leu Ser Lys Asn Asp Cys 
        115                 120                 125             


His Thr Asn Val Asn Asn Pro Val Val Thr Asn Ile Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Gly Leu Lys Ser Arg Leu Glu Gln Glu Phe Phe Gly Lys Thr Phe 
145                 150                 155                 160 


Glu Asn Asp Asn Leu His Val Gln Leu Ala Tyr Asn Ile Leu Asp Ile 
                165                 170                 175     


Lys Lys Ile Leu Gly Thr Tyr Val Asn Asn Ile Ile Tyr Ile Phe Tyr 
            180                 185                 190         


Asn Leu Asn Arg Ala Gly Thr Gly Arg Asp Glu Arg Met Tyr Asp Asp 
        195                 200                 205             


Leu Ile Gly Thr Leu Tyr Ala Tyr Lys Pro Met Glu Ala Gln Gln Thr 
    210                 215                 220                 


Tyr Leu Leu Lys Gly Asp Lys Asp Met Arg Arg Phe Glu Glu Val Lys 
225                 230                 235                 240 


Gln Leu Leu Gln Asn Thr Ser Ala Tyr Tyr Val Tyr Tyr Gly Thr Leu 
                245                 250                 255     


Phe Glu Lys Val Lys Ala Lys Ser Lys Lys Glu Gln Arg Ala Lys Glu 
            260                 265                 270         


Ala Glu Ile Asp Ala Cys Thr Ala His Asn Tyr Asp Val Leu Arg Leu 
        275                 280                 285             


Leu Ser Leu Met Arg Gln Leu Cys Met His Ser Val Ala Gly Thr Ala 
    290                 295                 300                 


Phe Lys Leu Ala Glu Ser Ala Leu Phe Asn Ile Glu Asp Val Leu Ser 
305                 310                 315                 320 


Ala Asp Leu Lys Glu Ile Leu Asp Glu Ala Phe Ser Gly Ala Val Asn 
                325                 330                 335     


Lys Leu Asn Asp Gly Phe Val Gln His Ser Gly Asn Asn Leu Tyr Val 
            340                 345                 350         


Leu Gln Gln Leu Tyr Pro Asn Glu Thr Ile Glu Arg Ile Ala Glu Lys 
        355                 360                 365             


Tyr Tyr Arg Leu Thr Val Arg Lys Glu Asp Leu Asn Met Gly Val Asn 
    370                 375                 380                 


Ile Lys Lys Leu Arg Glu Leu Ile Val Gly Gln Tyr Phe Pro Glu Val 
385                 390                 395                 400 


Leu Asp Lys Glu Tyr Asp Leu Ser Lys Asn Gly Asp Ser Val Val Thr 
                405                 410                 415     


Tyr Arg Ser Lys Ile Tyr Thr Val Met Asn Tyr Ile Leu Leu Tyr Tyr 
            420                 425                 430         


Leu Glu Asp His Asp Ser Ser Arg Glu Ser Met Val Glu Ala Leu Arg 
        435                 440                 445             


Gln Asn Arg Glu Gly Asp Glu Gly Lys Glu Glu Ile Tyr Arg Gln Phe 
    450                 455                 460                 


Ala Lys Lys Val Trp Asn Gly Val Ser Gly Leu Phe Gly Val Cys Leu 
465                 470                 475                 480 


Asn Leu Phe Lys Thr Glu Lys Arg Asn Lys Phe Arg Ser Lys Val Ala 
                485                 490                 495     


Leu Pro Asp Val Ser Gly Ala Ala Tyr Met Leu Ser Ser Glu Asn Ile 
            500                 505                 510         


Asp Tyr Phe Val Lys Met Leu Phe Phe Val Cys Lys Phe Leu Asp Gly 
        515                 520                 525             


Lys Glu Ile Asn Glu Leu Leu Cys Ala Leu Ile Asn Lys Phe Asp Asn 
    530                 535                 540                 


Ile Ala Asp Ile Leu Asp Ala Ala Ala Gln Cys Gly Ser Ser Val Trp 
545                 550                 555                 560 


Phe Val Asp Ser Tyr Arg Phe Phe Glu Arg Ser Arg Arg Ile Ser Ala 
                565                 570                 575     


Gln Ile Arg Ile Val Lys Asn Ile Ala Ser Lys Asp Phe Lys Lys Ser 
            580                 585                 590         


Lys Lys Asp Ser Asp Glu Ser Tyr Pro Glu Gln Leu Tyr Leu Asp Ala 
        595                 600                 605             


Leu Ala Leu Leu Gly Asp Val Ile Ser Lys Tyr Lys Gln Asn Arg Asp 
    610                 615                 620                 


Gly Ser Val Val Ile Asp Asp Gln Gly Asn Ala Val Leu Thr Glu Gln 
625                 630                 635                 640 


Tyr Lys Arg Phe Arg Tyr Glu Phe Phe Glu Glu Ile Lys Arg Asp Glu 
                645                 650                 655     


Ser Gly Gly Ile Lys Tyr Lys Lys Ser Gly Lys Pro Glu Tyr Asn His 
            660                 665                 670         


Gln Arg Arg Asn Phe Ile Leu Asn Asn Val Leu Lys Ser Lys Trp Phe 
        675                 680                 685             


Phe Tyr Val Val Lys Tyr Asn Arg Pro Ser Ser Cys Arg Glu Leu Met 
    690                 695                 700                 


Lys Asn Lys Glu Ile Leu Arg Phe Val Leu Arg Asp Ile Pro Asp Ser 
705                 710                 715                 720 


Gln Val Arg Arg Tyr Phe Lys Ala Val Gln Gly Glu Glu Ala Tyr Ala 
                725                 730                 735     


Ser Ala Glu Ala Met Arg Thr Arg Leu Val Asp Ala Leu Ser Gln Phe 
            740                 745                 750         


Ser Val Thr Ala Cys Leu Asp Glu Val Gly Gly Met Thr Asp Lys Glu 
        755                 760                 765             


Phe Ala Ser Gln Arg Ala Val Asp Ser Lys Glu Lys Leu Arg Ala Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Leu Thr Val Ala Tyr Leu Ile Thr Lys Ser Met Val 
785                 790                 795                 800 


Lys Val Asn Thr Arg Phe Ser Ile Ala Phe Ser Val Leu Glu Arg Asp 
                805                 810                 815     


Tyr Tyr Leu Leu Ile Asp Gly Lys Lys Lys Ser Ser Asp Tyr Thr Gly 
            820                 825                 830         


Glu Asp Met Leu Ala Leu Thr Arg Lys Phe Val Gly Glu Asp Ala Gly 
        835                 840                 845             


Leu Tyr Arg Glu Trp Lys Glu Lys Asn Ala Glu Ala Lys Asp Lys Tyr 
    850                 855                 860                 


Phe Asp Lys Ala Glu Arg Lys Lys Val Leu Arg Gln Asn Asp Lys Met 
865                 870                 875                 880 


Ile Arg Lys Met His Phe Thr Pro His Ser Leu Asn Tyr Val Gln Lys 
                885                 890                 895     


Asn Leu Glu Ser Val Gln Ser Asn Gly Leu Ala Ala Val Ile Lys Glu 
            900                 905                 910         


Tyr Arg Asn Ala Val Ala His Leu Asn Ile Ile Asn Arg Leu Asp Glu 
        915                 920                 925             


Tyr Ile Gly Ser Ala Arg Ala Asp Ser Tyr Tyr Ser Leu Tyr Cys Tyr 
    930                 935                 940                 


Cys Leu Gln Met Tyr Leu Ser Lys Asn Phe Ser Val Gly Tyr Leu Ile 
945                 950                 955                 960 


Asn Val Gln Lys Gln Leu Glu Glu His His Thr Tyr Met Lys Asp Leu 
                965                 970                 975     


Met Trp Leu Leu Asn Ile Pro Phe Ala Tyr Asn Leu Ala Arg Tyr Lys 
            980                 985                 990         


Asn Leu Ser Asn Glu Lys Leu Phe  Tyr Asp Glu Glu Ala  Ala Ala Glu 
        995                 1000                 1005             


Lys Ala  Asp Lys Ala Glu Asn  Glu Arg Gly Glu 
    1010                 1015                 


<210>  573
<211>  4561
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  active Cas13d AAV vector

<400>  573
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattagaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg tacaatagcc ctgcagtaag gcagggttct aagaccagca gcagcagcag      300

cagcagcagc attttttcca ccacactgga ctagtggatc tctgcagccc tccttaggac      360

ccatgcctcc tcaggtaccc cctgcccccc acagctcctc tcctgtgcct tgtttcccag      420

ccatgcgttc tcctctataa atacccgctc tggtatttgg ggttggcagc tgttgctgcc      480

agggagatgg ttgggttgac atgcggctcc tgacaaaaca caaacccctg gtgtgtgtgg      540

gcgtgggtgg tgtgagtagg gggatgaatc agggaggggg caggggaccc agggggcagg      600

agccacacaa agtctgtgcg ggggtgggag cgcacatagc aattggaaac tgaaagctta      660

tcagaccctt tctggaaatc agcccactgt ttataaactt gaggccccac cctcgagata      720

accagggctg aaagaggccc gcctgggggc tgcagacatg cttgctgcct gccctggcga      780

aggattggca ggcttgcccg tcacaggacc cccgctggct gactcagggg cgcaggcctt      840

ttgcggggga gctggcctcc ccgcccccac ggccacgggc cgccctttcc tggcaggaca      900

gcgggatctt gcagctgtca ggggagggga ggcgggggct gatgtcagga gggatataaa      960

tagtgccgac ggctgggggc cctgtctccc ctcgccgcat ccactctccg gccggccgcc     1020

tgcccgccgc ctcctccgtg cgcccgccag cctcgcccgc gccgtcacgc gtgccgccac     1080

catgaagaag aagcaccaga gcgccgccga gaagaggcaa gtgaagaagc tcaagaatca     1140

agagaaggcc cagaagtacg ctagcgagcc ttcccccctc cagagcgata cagctggcgt     1200

ggaatgctcc cagaaaaaga cagtcgtcag ccacattgcc agctccaaga cactggccaa     1260

ggctatggga ctcaaatcca cactggtcat gggcgacaag ctggtcatca ccagctttgc     1320

tgctagcaag gctgtcggag gcgctggcta caaaagcgct aacattgaaa aaatcacaga     1380

tctgcaagga agggtcattg aggagcacga aaggatgttt agcgccgatg tcggagagaa     1440

aaatatcgaa ctgagcaaga atgactgcca caccaacgtc aacaaccccg tggtgaccaa     1500

catcggaaag gattacatcg gactgaaatc taggctggag caagagtttt tcggcaagac     1560

attcgagaat gacaatctgc atgtgcagct ggcctacaat atcctcgaca tcaagaaaat     1620

tctgggaacc tatgtgaaca atatcattta tatcttctac aatctgaata gggctggcac     1680

cggcagagat gagaggatgt atgacgacct catcggcaca ctgtacgctt acaaacccat     1740

ggaggctcaa cagacctatc tgctcaaagg cgacaaggat atgaggaggt ttgaggaggt     1800

gaaacagctg ctgcaaaaca cctccgctta ctatgtgtat tacggcacac tgttcgagaa     1860

ggtgaaggct aagagcaaga aggaacagag ggctaaggag gccgaaatcg acgcttgtac     1920

cgcccataac tacgatgtgc tgagactgct gtccctcatg aggcagctgt gcatgcactc     1980

cgtcgctgga acagccttta agctggctga gtccgctctg ttcaacattg aggatgtgct     2040

cagcgccgat ctgaaggaaa tcctcgatga agccttctcc ggcgccgtga acaagctcaa     2100

tgacggattc gtgcagcact ccggcaacaa tctgtacgtg ctccagcagc tgtaccctaa     2160

tgagaccatc gagagaatcg ccgagaagta ctacagactc accgtgagga aggaggatct     2220

gaacatggga gtcaacatta aaaagctgag ggagctgatc gtgggccaat actttcccga     2280

ggtcctcgac aaagaatacg acctctccaa gaatggagac agcgtggtga catacagaag     2340

caagatttat accgtgatga attacattct gctgtattac ctcgaggacc acgactccag     2400

cagagaaagc atggtcgaag ctctgagaca aaacagagag ggcgatgaag gcaaggagga     2460

gatctataga cagtttgcca agaaggtgtg gaacggcgtg tccggactgt ttggcgtgtg     2520

tctgaacctc ttcaagaccg aaaagagaaa caagtttagg agcaaagtcg ccctccccga     2580

tgtgtccggc gctgcctata tgctctcctc cgagaacatc gactactttg tcaagatgct     2640

cttctttgtg tgtaagtttc tggatggcaa agaaatcaac gagctgctgt gcgctctgat     2700

caacaaattt gataatattg ccgatattct ggatgctgcc gctcaatgtg gctcctccgt     2760

ctggttcgtg gacagctata ggttcttcga gagatctagg aggattagcg cccagattag     2820

aatcgtgaag aacatcgctt ccaaggattt taagaaatcc aagaaggatt ccgatgagag     2880

ctaccccgag cagctgtatc tggatgctct ggctctgctc ggagacgtca tctccaagta     2940

caagcagaat agagatggca gcgtcgtcat cgatgaccaa ggcaatgccg tgctgacaga     3000

gcaatacaag aggtttagat atgaattttt cgaggagatc aagagggacg aaagcggcgg     3060

catcaagtac aagaagtccg gaaaacccga gtacaaccat cagagaagga attttattct     3120

gaataatgtg ctgaaaagca aatggttttt ctatgtggtg aagtacaata ggcccagcag     3180

ctgcagagaa ctgatgaaga ataaggaaat tctgaggttc gtgctgagag acatccccga     3240

ctcccaagtg agaagatact ttaaggccgt ccaaggagag gaagcttacg ctagcgccga     3300

agctatgagg acaagactgg tcgacgctct gtcccaattt agcgtcacag cttgtctgga     3360

tgaagtgggc ggcatgacag acaaggaatt cgcctcccag agggccgtcg atagcaaaga     3420

aaaactgaga gccatcatca gactgtatct gacagtcgcc tatctgatta ccaagagcat     3480

ggtgaaggtg aatacaaggt ttagcattgc ctttagcgtg ctggagaggg actactatct     3540

gctcattgac ggcaagaaga aatccagcga ctacaccgga gaggatatgc tggctctgac     3600

cagaaaattt gtgggcgaag atgctggact gtatagagag tggaaagaga agaacgctga     3660

agccaaggac aaatattttg acaaggccga aaggaagaag gtgctgagac agaacgataa     3720

gatgatcaga aagatgcact tcacacccca ctccctcaat tacgtccaaa agaatctcga     3780

aagcgtccag agcaacggac tggccgccgt catcaaggaa tatagaaatg ccgtcgctca     3840

cctcaatatc atcaatagac tggacgagta cattggctcc gctagggctg atagctacta     3900

ctctctgtac tgttactgcc tccaaatgta tctgagcaag aacttcagcg tgggctacct     3960

catcaacgtg caaaagcagc tggaggagca ccacacctac atgaaggatc tcatgtggct     4020

gctcaacatc cccttcgctt acaacctcgc cagatacaaa aatctgtcca acgaaaaact     4080

cttttacgac gaggaagccg ccgccgaaaa ggctgacaag gctgagaacg agagaggcga     4140

aggaagcccc aagaagaaaa ggaaggtcta aatccgatcc accggatcta gagataatca     4200

acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg ttgctccttt     4260

tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt cccgtatggc     4320

tttcattttc tcctccttgt ataaatcctg gttagttctt gccacggcgg aactcatcgc     4380

cgcctgcctt gcccgctgct ggacaggggc tcggctgttg ggcactgaca attccgtgga     4440

acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa     4500

ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt     4560

a                                                                     4561


<210>  574
<211>  1707
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  A02205 vector

<400>  574
gaccgtgtgc tcaaaagaag tgctgaagga agcaaccctc ctaaaccact gaaaaaacta       60

cgcggaggat cgggacgaag ccgactcttg gaagacttca gaaacaatcg gtatccgaac      120

cttcagctga gagaaattgc tggtcacatc atggaatttt ctcaagatca acatggaagc      180

cggtttattg aacttaaact cgaacgagcc accccggccg aaaggcaatt ggtgttcaat      240

gaaattcttc aggccgcata ccaactcatg gttgatgttt ttgggaacta tgttattcaa      300

aagttttttg agttcgggtc actggagcaa aagttggcat tggcagagcg aatccggggc      360

catgttctga gcctcgctct ccaaatgtac ggtagttatg tcattcgcaa agcactcgag      420

ttcataccat cagatcaaca gaatgagatg gtgcgggagc tggatgggca tgttttgaaa      480

tgcgtgaaag accaaaacgg tagctacgta gttgagaaat gcatcgaatg cgtccaacca      540

cagtctctcc aatttattat agatgcattt aagggtcagg ttttcgcgct ttctacgcac      600

ccgtatggga accgagtgat tcagagaatc ttggagcact gcctgccgga tcagacactc      660

cctatcttgg aggaattgca ccagcatacc gaacaattgg tgcaagatca atacggttca      720

tatgttattc ggcacgttct tgagcatgga aggccagagg acaagtcaaa gatcgtcgct      780

gagattagag gtaacgtatt ggtgctctca caacacaaat ttgcatctaa tgtggtggag      840

aaatgtgtta ctcatgcttc tagaacggaa agggcagttc tcatagacga agtttgcaca      900

atgaatgatg gtcctcatag cgcactttat accatgatga aggaccagta tgcaaactat      960

gtcgtccaga aaatgatcga tgtggcggag cccggtcaac ggaaaatcgt gatgcacaaa     1020

atccgacctc acattgctac actcagaaaa tacacgtatg gaaaacatat tctggctaag     1080

ctggagaaat attacatgaa gaatggagtg gatctggggg tggatactgc caatggcagc     1140

ggtggtggca cccctaaggc tcccaacctg gagcctccac tcccagaaga ggaaaaggag     1200

ggcagcgacc tgagaccagt ggtcatcgat gggagcaacg tggccatgag ccatgggaac     1260

aaggaggtct tctcctgccg gggcatcctg ctggcagtga actggtttct ggagcggggc     1320

cacacagaca tcacagtgtt tgtgccatcc tggaggaagg agcagcctcg gcccgacgtg     1380

cccatcacag accagcacat cctgcgggaa ctggagaaga agaagatcct ggtgttcaca     1440

ccatcacgac gcgtgggtgg caagcgggtg gtgtgctatg acgacagatt cattgtgaag     1500

ctggcctacg agtctgacgg gatcgtggtt tccaacgaca cataccgtga cctccaaggc     1560

gagcggcagg agtggaagcg cttcatcgag gagcggctgc tcatgtactc cttcgtcaat     1620

gacaagttta tgccccctga tgacccactg ggccggcacg ggcccagcct ggacaacttc     1680

ctgcgtaaga agccactcac tttggag                                         1707


<210>  575
<211>  4063
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  A02205 vector with ITRs

<400>  575
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccggtc gcgtctagta ctagttaccc cctgcccccc acagctcctc      180

tcctgtgcct tgtttcccag ccatgcgttc tcctctataa atacccgctc tggtatttgg      240

ggttggcagc tgttgctgcc agggagatgg ttgggttgac atgcggctcc tgacaaaaca      300

caaacccctg gtgtgtgtgg gcgtgggtgg tgtgagtagg gggatgaatc agggaggggg      360

caggggaccc agggggcagg agccacacaa agtctgtgcg ggggtgggag cgcacatagc      420

aattggaaac tgaaagctta tcagaccctt tctggaaatc agcccactgt ttataaactt      480

gaggccccac cctcgacagt accggggagg aagagggcct gcactagtcc agagggaaac      540

tgaggctcag ggccagctcg cccatagaca tacatggcag gcaggctttg gccaggatcc      600

ctccgcctgc caggcgtctc cctgccctcc cttcctgcct agagaccccc accctcaagc      660

ctggctggtc tttgcctgag acccaaacct cttcgacttc aagagaatat ttaggaacaa      720

ggtggtttag ggcctttcct gggaacaggc cttgaccctt taagaaatga cccaaagtct      780

ctccttgacc aaaaagggga ccctcaaact aaagggaagc ctctcttctg ctgtctcccc      840

tgaccccact cccccccacc ccaggacgag gagataacca gggctgaaag aggcccgcct      900

gggggctgca gacatgcttg ctgcctgccc tggcgaagga ttggcaggct tgcccgtcac      960

aggacccccg ctggctgact caggggcgca ggccttttgc gggggagctg gcctccccgc     1020

ccccacggcc acgggccgcc ctttcctggc aggacagcgg gatcttgcag ctgtcagggg     1080

aggggaggcg ggggctgatg tcaggaggga tacaaatagt gccgacggct gggggccctg     1140

tctcccctcg ccgcatccac tctccggccg gccgcctgcc cgccgcctcc tccgtgcgcc     1200

cgccagcctc gcccggctag cgccgccacc atggaccgtg tgctcaaaag aagtgctgaa     1260

ggaagcaacc ctcctaaacc actgaaaaaa ctacgcggag gatcgggacg aagccgactc     1320

ttggaagact tcagaaacaa tcggtatccg aaccttcagc tgagagaaat tgctggtcac     1380

atcatggaat tttctcaaga tcaacatgga agccggttta ttgaacttaa actcgaacga     1440

gccaccccgg ccgaaaggca attggtgttc aatgaaattc ttcaggccgc ataccaactc     1500

atggttgatg tttttgggaa ctatgttatt caaaagtttt ttgagttcgg gtcactggag     1560

caaaagttgg cattggcaga gcgaatccgg ggccatgttc tgagcctcgc tctccaaatg     1620

tacggtagtt atgtcattcg caaagcactc gagttcatac catcagatca acagaatgag     1680

atggtgcggg agctggatgg gcatgttttg aaatgcgtga aagaccaaaa cggtagctac     1740

gtagttgaga aatgcatcga atgcgtccaa ccacagtctc tccaatttat tatagatgca     1800

tttaagggtc aggttttcgc gctttctacg cacccgtatg ggaaccgagt gattcagaga     1860

atcttggagc actgcctgcc ggatcagaca ctccctatct tggaggaatt gcaccagcat     1920

accgaacaat tggtgcaaga tcaatacggt tcatatgtta ttcggcacgt tcttgagcat     1980

ggaaggccag aggacaagtc aaagatcgtc gctgagatta gaggtaacgt attggtgctc     2040

tcacaacaca aatttgcatc taatgtggtg gagaaatgtg ttactcatgc ttctagaacg     2100

gaaagggcag ttctcataga cgaagtttgc acaatgaatg atggtcctca tagcgcactt     2160

tataccatga tgaaggacca gtatgcaaac tatgtcgtcc agaaaatgat cgatgtggcg     2220

gagcccggtc aacggaaaat cgtgatgcac aaaatccgac ctcacattgc tacactcaga     2280

aaatacacgt atggaaaaca tattctggct aagctggaga aatattacat gaagaatgga     2340

gtggatctgg gggtggatac tgccaatggc agcggtggtg gcacccctaa ggctcccaac     2400

ctggagcctc cactcccaga agaggaaaag gagggcagcg acctgagacc agtggtcatc     2460

gatgggagca acgtggccat gagccatggg aacaaggagg tcttctcctg ccggggcatc     2520

ctgctggcag tgaactggtt tctggagcgg ggccacacag acatcacagt gtttgtgcca     2580

tcctggagga aggagcagcc tcggcccgac gtgcccatca cagaccagca catcctgcgg     2640

gaactggaga agaagaagat cctggtgttc acaccatcac gacgcgtggg tggcaagcgg     2700

gtggtgtgct atgacgacag attcattgtg aagctggcct acgagtctga cgggatcgtg     2760

gtttccaacg acacataccg tgacctccaa ggcgagcggc aggagtggaa gcgcttcatc     2820

gaggagcggc tgctcatgta ctccttcgtc aatgacaagt ttatgccccc tgatgaccca     2880

ctgggccggc acgggcccag cctggacaac ttcctgcgta agaagccact cactttggag     2940

taatcgcggc cgctcgagga ttataaggat gacgacgata aattcgtcga gcaccaccac     3000

caccaccact aataaggttt atccgatcca ccggatctag ataagatatc cgatccaccg     3060

gatctagata actgatcata atcagccata ccacatttgt agaggtttta cttgctttaa     3120

aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta     3180

atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc     3240

cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta     3300

tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt     3360

ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg     3420

gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta     3480

ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt     3540

tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg     3600

cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca     3660

atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc     3720

gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcaa cttgtttatt     3780

gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt     3840

ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta acgcggtaac     3900

cacgtgcgga cccaacggcc gcaggaaccc ctagtgatgg agttggccac tccctctctg     3960

cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc     4020

cgggcggcct cagtgagcga gcgagcgcgc agctgcctgc agg                       4063


<210>  576
<211>  1119
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  A02239 PUF vector

<400>  576
gaccgtgtgc tcaaaagaag tgctgaagga agcaaccctc ctaaaccact gaaaaaacta       60

cgcggaggat cgggacgaag ccgactcttg gaagacttca gaaacaatcg gtatccgaac      120

cttcagctga gagaaattgc tggtcacatc atggaatttt ctcaagatca acatggaagc      180

cggtttattg aacttaaact cgaacgagcc accccggccg aaaggcaatt ggtgttcaat      240

gaaattcttc aggccgcata ccaactcatg gttgatgttt ttgggaacta tgttattcaa      300

aagttttttg agttcgggtc actggagcaa aagttggcat tggcagagcg aatccggggc      360

catgttctga gcctcgctct ccaaatgtac ggtagttatg tcattcgcaa agcactcgag      420

ttcataccat cagatcaaca gaatgagatg gtgcgggagc tggatgggca tgttttgaaa      480

tgcgtgaaag accaaaacgg tagctacgta gttgagaaat gcatcgaatg cgtccaacca      540

cagtctctcc aatttattat agatgcattt aagggtcagg ttttcgcgct ttctacgcac      600

ccgtatggga accgagtgat tcagagaatc ttggagcact gcctgccgga tcagacactc      660

cctatcttgg aggaattgca ccagcatacc gaacaattgg tgcaagatca atacggttca      720

tatgttattc ggcacgttct tgagcatgga aggccagagg acaagtcaaa gatcgtcgct      780

gagattagag gtaacgtatt ggtgctctca caacacaaat ttgcatctaa tgtggtggag      840

aaatgtgtta ctcatgcttc tagaacggaa agggcagttc tcatagacga agtttgcaca      900

atgaatgatg gtcctcatag cgcactttat accatgatga aggaccagta tgcaaactat      960

gtcgtccaga aaatgatcga tgtggcggag cccggtcaac ggaaaatcgt gatgcacaaa     1020

atccgacctc acattgctac actcagaaaa tacacgtatg gaaaacatat tctggctaag     1080

ctggagaaat attacatgaa gaatggagtg gatctgggg                            1119


<210>  577
<211>  3475
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  A02239 PUF vector with ITRS

<400>  577
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccggtc gcgtctagta ctagttaccc cctgcccccc acagctcctc      180

tcctgtgcct tgtttcccag ccatgcgttc tcctctataa atacccgctc tggtatttgg      240

ggttggcagc tgttgctgcc agggagatgg ttgggttgac atgcggctcc tgacaaaaca      300

caaacccctg gtgtgtgtgg gcgtgggtgg tgtgagtagg gggatgaatc agggaggggg      360

caggggaccc agggggcagg agccacacaa agtctgtgcg ggggtgggag cgcacatagc      420

aattggaaac tgaaagctta tcagaccctt tctggaaatc agcccactgt ttataaactt      480

gaggccccac cctcgacagt accggggagg aagagggcct gcactagtcc agagggaaac      540

tgaggctcag ggccagctcg cccatagaca tacatggcag gcaggctttg gccaggatcc      600

ctccgcctgc caggcgtctc cctgccctcc cttcctgcct agagaccccc accctcaagc      660

ctggctggtc tttgcctgag acccaaacct cttcgacttc aagagaatat ttaggaacaa      720

ggtggtttag ggcctttcct gggaacaggc cttgaccctt taagaaatga cccaaagtct      780

ctccttgacc aaaaagggga ccctcaaact aaagggaagc ctctcttctg ctgtctcccc      840

tgaccccact cccccccacc ccaggacgag gagataacca gggctgaaag aggcccgcct      900

gggggctgca gacatgcttg ctgcctgccc tggcgaagga ttggcaggct tgcccgtcac      960

aggacccccg ctggctgact caggggcgca ggccttttgc gggggagctg gcctccccgc     1020

ccccacggcc acgggccgcc ctttcctggc aggacagcgg gatcttgcag ctgtcagggg     1080

aggggaggcg ggggctgatg tcaggaggga tacaaatagt gccgacggct gggggccctg     1140

tctcccctcg ccgcatccac tctccggccg gccgcctgcc cgccgcctcc tccgtgcgcc     1200

cgccagcctc gcccggctag cgccgccacc atggaccgtg tgctcaaaag aagtgctgaa     1260

ggaagcaacc ctcctaaacc actgaaaaaa ctacgcggag gatcgggacg aagccgactc     1320

ttggaagact tcagaaacaa tcggtatccg aaccttcagc tgagagaaat tgctggtcac     1380

atcatggaat tttctcaaga tcaacatgga agccggttta ttgaacttaa actcgaacga     1440

gccaccccgg ccgaaaggca attggtgttc aatgaaattc ttcaggccgc ataccaactc     1500

atggttgatg tttttgggaa ctatgttatt caaaagtttt ttgagttcgg gtcactggag     1560

caaaagttgg cattggcaga gcgaatccgg ggccatgttc tgagcctcgc tctccaaatg     1620

tacggtagtt atgtcattcg caaagcactc gagttcatac catcagatca acagaatgag     1680

atggtgcggg agctggatgg gcatgttttg aaatgcgtga aagaccaaaa cggtagctac     1740

gtagttgaga aatgcatcga atgcgtccaa ccacagtctc tccaatttat tatagatgca     1800

tttaagggtc aggttttcgc gctttctacg cacccgtatg ggaaccgagt gattcagaga     1860

atcttggagc actgcctgcc ggatcagaca ctccctatct tggaggaatt gcaccagcat     1920

accgaacaat tggtgcaaga tcaatacggt tcatatgtta ttcggcacgt tcttgagcat     1980

ggaaggccag aggacaagtc aaagatcgtc gctgagatta gaggtaacgt attggtgctc     2040

tcacaacaca aatttgcatc taatgtggtg gagaaatgtg ttactcatgc ttctagaacg     2100

gaaagggcag ttctcataga cgaagtttgc acaatgaatg atggtcctca tagcgcactt     2160

tataccatga tgaaggacca gtatgcaaac tatgtcgtcc agaaaatgat cgatgtggcg     2220

gagcccggtc aacggaaaat cgtgatgcac aaaatccgac ctcacattgc tacactcaga     2280

aaatacacgt atggaaaaca tattctggct aagctggaga aatattacat gaagaatgga     2340

gtggatctgg ggtaatcgcg gccgctcgag gattataagg atgacgacga taaattcgtc     2400

gagcaccacc accaccacca ctaataaggt ttatccgatc caccggatct agataagata     2460

tccgatccac cggatctaga taactgatca taatcagcca taccacattt gtagaggttt     2520

tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa atgaatgcaa     2580

ttgttgttgt taatcaacct ctggattaca aaatttgtga aagattgact ggtattctta     2640

actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta     2700

ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt     2760

atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg     2820

caacccccac tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt     2880

tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag     2940

gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaaatca tcgtcctttc     3000

cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc     3060

cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc     3120

ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc     3180

aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca     3240

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct     3300

taacgcggta accacgtgcg gacccaacgg ccgcaggaac ccctagtgat ggagttggcc     3360

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     3420

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct gcagg          3475


<210>  578
<211>  1119
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  blocking 8 PUF vector

<400>  578
gaccgtgtgc tcaaaagaag tgctgaagga agcaaccctc ctaaaccact gaaaaaacta       60

cgcggaggat cgggacgaag ccgactcttg gaagacttca gaaacaatcg gtatccgaac      120

cttcagctga gagaaattgc tggtcacatc atggaatttt ctcaagatca acatggaagc      180

cggtttattg aacttaaact cgaacgagcc accccggccg aaaggcaatt ggtgttcaat      240

gaaattcttc aggccgcata ccaactcatg gttgatgttt ttgggaacta tgttattcaa      300

aagttttttg agttcgggtc actggagcaa aagttggcat tggcagagcg aatccggggc      360

catgttctga gcctcgctct ccaaatgtac ggtagttatg tcattcgcaa agcactcgag      420

ttcataccat cagatcaaca gaatgagatg gtgcgggagc tggatgggca tgttttgaaa      480

tgcgtgaaag accaaaacgg tagctacgta gttgagaaat gcatcgaatg cgtccaacca      540

cagtctctcc aatttattat agatgcattt aagggtcagg ttttcgcgct ttctacgcac      600

ccgtatggga accgagtgat tcagagaatc ttggagcact gcctgccgga tcagacactc      660

cctatcttgg aggaattgca ccagcatacc gaacaattgg tgcaagatca atacggttca      720

tatgttattc ggcacgttct tgagcatgga aggccagagg acaagtcaaa gatcgtcgct      780

gagattagag gtaacgtatt ggtgctctca caacacaaat ttgcatctaa tgtggtggag      840

aaatgtgtta ctcatgcttc tagaacggaa agggcagttc tcatagacga agtttgcaca      900

atgaatgatg gtcctcatag cgcactttat accatgatga aggaccagta tgcaaactat      960

gtcgtccaga aaatgatcga tgtggcggag cccggtcaac ggaaaatcgt gatgcacaaa     1020

atccgacctc acattgctac actcagaaaa tacacgtatg gaaaacatat tctggctaag     1080

ctggagaaat attacatgaa gaatggagtg gatctgggg                            1119


<210>  579
<211>  2814
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  blocking 8 PUF vector with ITRs

<400>  579
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccggtc gcgtctagtt attaatgcat actagtaatt ggctccggtg      180

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg      240

gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt      300

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg      360

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca gaattccagg taagtcccgc      420

agccgtaacg accttggggg ggtgtgagat tctcattcta attttgaaga atattaggtg      480

taaaagcaag aaatacaatg atcctgaggt gacacgctta tgttttactt ttaaactagg      540

tgaattcaag atctgctagc gccgccacca tggaccgtgt gctcaaaaga agtgctgaag      600

gaagcaaccc tcctaaacca ctgaaaaaac tacgcggagg atcgggacga agccgactct      660

tggaagactt cagaaacaat cggtatccga accttcagct gagagaaatt gctggtcaca      720

tcatggaatt ttctcaagat caacatggaa gccggtttat tgaacttaaa ctcgaacgag      780

ccaccccggc cgaaaggcaa ttggtgttca atgaaattct tcaggccgca taccaactca      840

tggttgatgt ttttgggaac tatgttattc aaaagttttt tgagttcggg tcactggagc      900

aaaagttggc attggcagag cgaatccggg gccatgttct gagcctcgct ctccaaatgt      960

acggtagtta tgtcattcgc aaagcactcg agttcatacc atcagatcaa cagaatgaga     1020

tggtgcggga gctggatggg catgttttga aatgcgtgaa agaccaaaac ggtagctacg     1080

tagttgagaa atgcatcgaa tgcgtccaac cacagtctct ccaatttatt atagatgcat     1140

ttaagggtca ggttttcgcg ctttctacgc acccgtatgg gaaccgagtg attcagagaa     1200

tcttggagca ctgcctgccg gatcagacac tccctatctt ggaggaattg caccagcata     1260

ccgaacaatt ggtgcaagat caatacggtt catatgttat tcggcacgtt cttgagcatg     1320

gaaggccaga ggacaagtca aagatcgtcg ctgagattag aggtaacgta ttggtgctct     1380

cacaacacaa atttgcatct aatgtggtgg agaaatgtgt tactcatgct tctagaacgg     1440

aaagggcagt tctcatagac gaagtttgca caatgaatga tggtcctcat agcgcacttt     1500

ataccatgat gaaggaccag tatgcaaact atgtcgtcca gaaaatgatc gatgtggcgg     1560

agcccggtca acggaaaatc gtgatgcaca aaatccgacc tcacattgct acactcagaa     1620

aatacacgta tggaaaacat attctggcta agctggagaa atattacatg aagaatggag     1680

tggatctggg gtaatcgcgg ccgctcgagg attataagga tgacgacgat aaattcgtcg     1740

agcaccacca ccaccaccac taataaggtt tatccgatcc accggatcta gataagatat     1800

ccgatccacc ggatctagat aactgatcat aatcagccat accacatttg tagaggtttt     1860

acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat     1920

tgttgttgtt aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa     1980

ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat     2040

tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta     2100

tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc     2160

aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt     2220

ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg     2280

ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc     2340

ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc     2400

ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct     2460

tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgca     2520

acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa     2580

ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt     2640

aacgcggtaa ccacgtgcgg acccaacggc cgcaggaacc cctagtgatg gagttggcca     2700

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     2760

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcctg cagg           2814


<210>  580
<211>  4890
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  active Cas13d AAV vector with ITRS

<400>  580
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccggtc gcgtctagta accggtgagg gcctatttcc catgattcct      180

tcatatttgc atatacgata caaggctgtt agagagataa ttagaattaa tttgactgta      240

aacacaaaga tattagtaca aaatacgtga cgtagaaagt aataatttct tgggtagttt      300

gcagttttaa aattatgttt taaaatggac tatcatatgc ttaccgtaac ttgaaagtat      360

ttcgatttct tggctttata tatcttgtgg aaaggacgaa acaccgtaca atagccctgc      420

agtaaggcag ggttctaaga ccagcagcag cagcagcagc agcagcattt tttccaccac      480

actggactag tggatctctg cagccctcct taggacccat gcctcctcag gtaccccctg      540

ccccccacag ctcctctcct gtgccttgtt tcccagccat gcgttctcct ctataaatac      600

ccgctctggt atttggggtt ggcagctgtt gctgccaggg agatggttgg gttgacatgc      660

ggctcctgac aaaacacaaa cccctggtgt gtgtgggcgt gggtggtgtg agtaggggga      720

tgaatcaggg agggggcagg ggacccaggg ggcaggagcc acacaaagtc tgtgcggggg      780

tgggagcgca catagcaatt ggaaactgaa agcttatcag accctttctg gaaatcagcc      840

cactgtttat aaacttgagg ccccaccctc gagataacca gggctgaaag aggcccgcct      900

gggggctgca gacatgcttg ctgcctgccc tggcgaagga ttggcaggct tgcccgtcac      960

aggacccccg ctggctgact caggggcgca ggccttttgc gggggagctg gcctccccgc     1020

ccccacggcc acgggccgcc ctttcctggc aggacagcgg gatcttgcag ctgtcagggg     1080

aggggaggcg ggggctgatg tcaggaggga tataaatagt gccgacggct gggggccctg     1140

tctcccctcg ccgcatccac tctccggccg gccgcctgcc cgccgcctcc tccgtgcgcc     1200

cgccagcctc gcccgcgccg tcacgcgtgc cgccaccatg aagaagaagc accagagcgc     1260

cgccgagaag aggcaagtga agaagctcaa gaatcaagag aaggcccaga agtacgctag     1320

cgagccttcc cccctccaga gcgatacagc tggcgtggaa tgctcccaga aaaagacagt     1380

cgtcagccac attgccagct ccaagacact ggccaaggct atgggactca aatccacact     1440

ggtcatgggc gacaagctgg tcatcaccag ctttgctgct agcaaggctg tcggaggcgc     1500

tggctacaaa agcgctaaca ttgaaaaaat cacagatctg caaggaaggg tcattgagga     1560

gcacgaaagg atgtttagcg ccgatgtcgg agagaaaaat atcgaactga gcaagaatga     1620

ctgccacacc aacgtcaaca accccgtggt gaccaacatc ggaaaggatt acatcggact     1680

gaaatctagg ctggagcaag agtttttcgg caagacattc gagaatgaca atctgcatgt     1740

gcagctggcc tacaatatcc tcgacatcaa gaaaattctg ggaacctatg tgaacaatat     1800

catttatatc ttctacaatc tgaatagggc tggcaccggc agagatgaga ggatgtatga     1860

cgacctcatc ggcacactgt acgcttacaa acccatggag gctcaacaga cctatctgct     1920

caaaggcgac aaggatatga ggaggtttga ggaggtgaaa cagctgctgc aaaacacctc     1980

cgcttactat gtgtattacg gcacactgtt cgagaaggtg aaggctaaga gcaagaagga     2040

acagagggct aaggaggccg aaatcgacgc ttgtaccgcc cataactacg atgtgctgag     2100

actgctgtcc ctcatgaggc agctgtgcat gcactccgtc gctggaacag cctttaagct     2160

ggctgagtcc gctctgttca acattgagga tgtgctcagc gccgatctga aggaaatcct     2220

cgatgaagcc ttctccggcg ccgtgaacaa gctcaatgac ggattcgtgc agcactccgg     2280

caacaatctg tacgtgctcc agcagctgta ccctaatgag accatcgaga gaatcgccga     2340

gaagtactac agactcaccg tgaggaagga ggatctgaac atgggagtca acattaaaaa     2400

gctgagggag ctgatcgtgg gccaatactt tcccgaggtc ctcgacaaag aatacgacct     2460

ctccaagaat ggagacagcg tggtgacata cagaagcaag atttataccg tgatgaatta     2520

cattctgctg tattacctcg aggaccacga ctccagcaga gaaagcatgg tcgaagctct     2580

gagacaaaac agagagggcg atgaaggcaa ggaggagatc tatagacagt ttgccaagaa     2640

ggtgtggaac ggcgtgtccg gactgtttgg cgtgtgtctg aacctcttca agaccgaaaa     2700

gagaaacaag tttaggagca aagtcgccct ccccgatgtg tccggcgctg cctatatgct     2760

ctcctccgag aacatcgact actttgtcaa gatgctcttc tttgtgtgta agtttctgga     2820

tggcaaagaa atcaacgagc tgctgtgcgc tctgatcaac aaatttgata atattgccga     2880

tattctggat gctgccgctc aatgtggctc ctccgtctgg ttcgtggaca gctataggtt     2940

cttcgagaga tctaggagga ttagcgccca gattagaatc gtgaagaaca tcgcttccaa     3000

ggattttaag aaatccaaga aggattccga tgagagctac cccgagcagc tgtatctgga     3060

tgctctggct ctgctcggag acgtcatctc caagtacaag cagaatagag atggcagcgt     3120

cgtcatcgat gaccaaggca atgccgtgct gacagagcaa tacaagaggt ttagatatga     3180

atttttcgag gagatcaaga gggacgaaag cggcggcatc aagtacaaga agtccggaaa     3240

acccgagtac aaccatcaga gaaggaattt tattctgaat aatgtgctga aaagcaaatg     3300

gtttttctat gtggtgaagt acaataggcc cagcagctgc agagaactga tgaagaataa     3360

ggaaattctg aggttcgtgc tgagagacat ccccgactcc caagtgagaa gatactttaa     3420

ggccgtccaa ggagaggaag cttacgctag cgccgaagct atgaggacaa gactggtcga     3480

cgctctgtcc caatttagcg tcacagcttg tctggatgaa gtgggcggca tgacagacaa     3540

ggaattcgcc tcccagaggg ccgtcgatag caaagaaaaa ctgagagcca tcatcagact     3600

gtatctgaca gtcgcctatc tgattaccaa gagcatggtg aaggtgaata caaggtttag     3660

cattgccttt agcgtgctgg agagggacta ctatctgctc attgacggca agaagaaatc     3720

cagcgactac accggagagg atatgctggc tctgaccaga aaatttgtgg gcgaagatgc     3780

tggactgtat agagagtgga aagagaagaa cgctgaagcc aaggacaaat attttgacaa     3840

ggccgaaagg aagaaggtgc tgagacagaa cgataagatg atcagaaaga tgcacttcac     3900

accccactcc ctcaattacg tccaaaagaa tctcgaaagc gtccagagca acggactggc     3960

cgccgtcatc aaggaatata gaaatgccgt cgctcacctc aatatcatca atagactgga     4020

cgagtacatt ggctccgcta gggctgatag ctactactct ctgtactgtt actgcctcca     4080

aatgtatctg agcaagaact tcagcgtggg ctacctcatc aacgtgcaaa agcagctgga     4140

ggagcaccac acctacatga aggatctcat gtggctgctc aacatcccct tcgcttacaa     4200

cctcgccaga tacaaaaatc tgtccaacga aaaactcttt tacgacgagg aagccgccgc     4260

cgaaaaggct gacaaggctg agaacgagag aggcgaagga agccccaaga agaaaaggaa     4320

ggtctaaatc cgatccaccg gatctagaga taatcaacct ctggattaca aaatttgtga     4380

aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt     4440

aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa     4500

atcctggtta gttcttgcca cggcggaact catcgccgcc tgccttgccc gctgctggac     4560

aggggctcgg ctgttgggca ctgacaattc cgtggaactt gtttattgca gcttataatg     4620

gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt     4680

ctagttgtgg tttgtccaaa ctcatcaatg tatcttaacg cggtaaccac gtgcggaccc     4740

aacggccgca ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc     4800

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag     4860

tgagcgagcg agcgcgcagc tgcctgcagg                                      4890


<210>  581
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  blocking 8 PUF myc tag vector

<400>  581
gaccgtgtgc tcaaaagaag tgctgaagga agcaaccctc ctaaaccact gaaaaaacta       60

cgcggaggat cgggacgaag ccgactcttg gaagacttca gaaacaatcg gtatccgaac      120

cttcagctga gagaaattgc tggtcacatc atggaatttt ctcaagatca acatggaagc      180

cggtttattg aacttaaact cgaacgagcc accccggccg aaaggcaatt ggtgttcaat      240

gaaattcttc aggccgcata ccaactcatg gttgatgttt ttgggaacta tgttattcaa      300

aagttttttg agttcgggtc actggagcaa aagttggcat tggcagagcg aatccggggc      360

catgttctga gcctcgctct ccaaatgtac ggtagttatg tcattcgcaa agcactcgag      420

ttcataccat cagatcaaca gaatgagatg gtgcgggagc tggatgggca tgttttgaaa      480

tgcgtgaaag accaaaacgg tagctacgta gttgagaaat gcatcgaatg cgtccaacca      540

cagtctctcc aatttattat agatgcattt aagggtcagg ttttcgcgct ttctacgcac      600

ccgtatggga accgagtgat tcagagaatc ttggagcact gcctgccgga tcagacactc      660

cctatcttgg aggaattgca ccagcatacc gaacaattgg tgcaagatca atacggttca      720

tatgttattc ggcacgttct tgagcatgga aggccagagg acaagtcaaa gatcgtcgct      780

gagattagag gtaacgtatt ggtgctctca caacacaaat ttgcatctaa tgtggtggag      840

aaatgtgtta ctcatgcttc tagaacggaa agggcagttc tcatagacga agtttgcaca      900

atgaatgatg gtcctcatag cgcactttat accatgatga aggaccagta tgcaaactat      960

gtcgtccaga aaatgatcga tgtggcggag cccggtcaac ggaaaatcgt gatgcacaaa     1020

atccgacctc acattgctac actcagaaaa tacacgtatg gaaaacatat tctggctaag     1080

ctggagaaat attacatgaa gaatggagtg gatctggggg gcggaagtga gcaaaaactg     1140

attagtgaag aagatctc                                                   1158


<210>  582
<211>  2853
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  blocking 8 PUF myc tag vector with ITRs

<400>  582
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccggtc gcgtctagtt attaatgcat actagtaatt ggctccggtg      180

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg      240

gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt      300

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg      360

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca gaattccagg taagtcccgc      420

agccgtaacg accttggggg ggtgtgagat tctcattcta attttgaaga atattaggtg      480

taaaagcaag aaatacaatg atcctgaggt gacacgctta tgttttactt ttaaactagg      540

tgaattcaag atctgctagc gccgccacca tggaccgtgt gctcaaaaga agtgctgaag      600

gaagcaaccc tcctaaacca ctgaaaaaac tacgcggagg atcgggacga agccgactct      660

tggaagactt cagaaacaat cggtatccga accttcagct gagagaaatt gctggtcaca      720

tcatggaatt ttctcaagat caacatggaa gccggtttat tgaacttaaa ctcgaacgag      780

ccaccccggc cgaaaggcaa ttggtgttca atgaaattct tcaggccgca taccaactca      840

tggttgatgt ttttgggaac tatgttattc aaaagttttt tgagttcggg tcactggagc      900

aaaagttggc attggcagag cgaatccggg gccatgttct gagcctcgct ctccaaatgt      960

acggtagtta tgtcattcgc aaagcactcg agttcatacc atcagatcaa cagaatgaga     1020

tggtgcggga gctggatggg catgttttga aatgcgtgaa agaccaaaac ggtagctacg     1080

tagttgagaa atgcatcgaa tgcgtccaac cacagtctct ccaatttatt atagatgcat     1140

ttaagggtca ggttttcgcg ctttctacgc acccgtatgg gaaccgagtg attcagagaa     1200

tcttggagca ctgcctgccg gatcagacac tccctatctt ggaggaattg caccagcata     1260

ccgaacaatt ggtgcaagat caatacggtt catatgttat tcggcacgtt cttgagcatg     1320

gaaggccaga ggacaagtca aagatcgtcg ctgagattag aggtaacgta ttggtgctct     1380

cacaacacaa atttgcatct aatgtggtgg agaaatgtgt tactcatgct tctagaacgg     1440

aaagggcagt tctcatagac gaagtttgca caatgaatga tggtcctcat agcgcacttt     1500

ataccatgat gaaggaccag tatgcaaact atgtcgtcca gaaaatgatc gatgtggcgg     1560

agcccggtca acggaaaatc gtgatgcaca aaatccgacc tcacattgct acactcagaa     1620

aatacacgta tggaaaacat attctggcta agctggagaa atattacatg aagaatggag     1680

tggatctggg gggcggaagt gagcaaaaac tgattagtga agaagatctc taatcgcggc     1740

cgctcgagga ttataaggat gacgacgata aattcgtcga gcaccaccac caccaccact     1800

aataaggttt atccgatcca ccggatctag ataagatatc cgatccaccg gatctagata     1860

actgatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc     1920

acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta atcaacctct     1980

ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc cttttacgct     2040

atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta tggctttcat     2100

tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt ggcccgttgt     2160

caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg gttggggcat     2220

tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta ttgccacggc     2280

ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga     2340

caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg cctgtgttgc     2400

cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca atccagcgga     2460

ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc gccttcgccc     2520

tcagacgagt cggatctccc tttgggccgc ctccccgcaa cttgtttatt gcagcttata     2580

atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc     2640

attctagttg tggtttgtcc aaactcatca atgtatctta acgcggtaac cacgtgcgga     2700

cccaacggcc gcaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     2760

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     2820

cagtgagcga gcgagcgcgc agctgcctgc agg                                  2853


<210>  583
<211>  1019
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  dead Cas12d 4 point mutations

<400>  583

Lys Lys Lys His Gln Ser Ala Ala Glu Lys Arg Gln Val Lys Lys Leu 
1               5                   10                  15      


Lys Asn Gln Glu Lys Ala Gln Lys Tyr Ala Ser Glu Pro Ser Pro Leu 
            20                  25                  30          


Gln Ser Asp Thr Ala Gly Val Glu Cys Ser Gln Lys Lys Thr Val Val 
        35                  40                  45              


Ser His Ile Ala Ser Ser Lys Thr Leu Ala Lys Ala Met Gly Leu Lys 
    50                  55                  60                  


Ser Thr Leu Val Met Gly Asp Lys Leu Val Ile Thr Ser Phe Ala Ala 
65                  70                  75                  80  


Ser Lys Ala Val Gly Gly Ala Gly Tyr Lys Ser Ala Asn Ile Glu Lys 
                85                  90                  95      


Ile Thr Asp Leu Gln Gly Arg Val Ile Glu Glu His Glu Arg Met Phe 
            100                 105                 110         


Ser Ala Asp Val Gly Glu Lys Asn Ile Glu Leu Ser Lys Asn Asp Cys 
        115                 120                 125             


His Thr Asn Val Asn Asn Pro Val Val Thr Asn Ile Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Gly Leu Lys Ser Arg Leu Glu Gln Glu Phe Phe Gly Lys Thr Phe 
145                 150                 155                 160 


Glu Asn Asp Asn Leu His Val Gln Leu Ala Tyr Asn Ile Leu Asp Ile 
                165                 170                 175     


Lys Lys Ile Leu Gly Thr Tyr Val Asn Asn Ile Ile Tyr Ile Phe Tyr 
            180                 185                 190         


Asn Leu Asn Arg Ala Gly Thr Gly Arg Asp Glu Arg Met Tyr Asp Asp 
        195                 200                 205             


Leu Ile Gly Thr Leu Tyr Ala Tyr Lys Pro Met Glu Ala Gln Gln Thr 
    210                 215                 220                 


Tyr Leu Leu Lys Gly Asp Lys Asp Met Arg Arg Phe Glu Glu Val Lys 
225                 230                 235                 240 


Gln Leu Leu Gln Asn Thr Ser Ala Tyr Tyr Val Tyr Tyr Gly Thr Leu 
                245                 250                 255     


Phe Glu Lys Val Lys Ala Lys Ser Lys Lys Glu Gln Arg Ala Lys Glu 
            260                 265                 270         


Ala Glu Ile Asp Ala Cys Thr Ala His Asn Tyr Asp Val Leu Arg Leu 
        275                 280                 285             


Leu Ser Leu Met Ala Gln Leu Cys Met Ala Ser Val Ala Gly Thr Ala 
    290                 295                 300                 


Phe Lys Leu Ala Glu Ser Ala Leu Phe Asn Ile Glu Asp Val Leu Ser 
305                 310                 315                 320 


Ala Asp Leu Lys Glu Ile Leu Asp Glu Ala Phe Ser Gly Ala Val Asn 
                325                 330                 335     


Lys Leu Asn Asp Gly Phe Val Gln His Ser Gly Asn Asn Leu Tyr Val 
            340                 345                 350         


Leu Gln Gln Leu Tyr Pro Asn Glu Thr Ile Glu Arg Ile Ala Glu Lys 
        355                 360                 365             


Tyr Tyr Arg Leu Thr Val Arg Lys Glu Asp Leu Asn Met Gly Val Asn 
    370                 375                 380                 


Ile Lys Lys Leu Arg Glu Leu Ile Val Gly Gln Tyr Phe Pro Glu Val 
385                 390                 395                 400 


Leu Asp Lys Glu Tyr Asp Leu Ser Lys Asn Gly Asp Ser Val Val Thr 
                405                 410                 415     


Tyr Arg Ser Lys Ile Tyr Thr Val Met Asn Tyr Ile Leu Leu Tyr Tyr 
            420                 425                 430         


Leu Glu Asp His Asp Ser Ser Arg Glu Ser Met Val Glu Ala Leu Arg 
        435                 440                 445             


Gln Asn Arg Glu Gly Asp Glu Gly Lys Glu Glu Ile Tyr Arg Gln Phe 
    450                 455                 460                 


Ala Lys Lys Val Trp Asn Gly Val Ser Gly Leu Phe Gly Val Cys Leu 
465                 470                 475                 480 


Asn Leu Phe Lys Thr Glu Lys Arg Asn Lys Phe Arg Ser Lys Val Ala 
                485                 490                 495     


Leu Pro Asp Val Ser Gly Ala Ala Tyr Met Leu Ser Ser Glu Asn Ile 
            500                 505                 510         


Asp Tyr Phe Val Lys Met Leu Phe Phe Val Cys Lys Phe Leu Asp Gly 
        515                 520                 525             


Lys Glu Ile Asn Glu Leu Leu Cys Ala Leu Ile Asn Lys Phe Asp Asn 
    530                 535                 540                 


Ile Ala Asp Ile Leu Asp Ala Ala Ala Gln Cys Gly Ser Ser Val Trp 
545                 550                 555                 560 


Phe Val Asp Ser Tyr Arg Phe Phe Glu Arg Ser Arg Arg Ile Ser Ala 
                565                 570                 575     


Gln Ile Arg Ile Val Lys Asn Ile Ala Ser Lys Asp Phe Lys Lys Ser 
            580                 585                 590         


Lys Lys Asp Ser Asp Glu Ser Tyr Pro Glu Gln Leu Tyr Leu Asp Ala 
        595                 600                 605             


Leu Ala Leu Leu Gly Asp Val Ile Ser Lys Tyr Lys Gln Asn Arg Asp 
    610                 615                 620                 


Gly Ser Val Val Ile Asp Asp Gln Gly Asn Ala Val Leu Thr Glu Gln 
625                 630                 635                 640 


Tyr Lys Arg Phe Arg Tyr Glu Phe Phe Glu Glu Ile Lys Arg Asp Glu 
                645                 650                 655     


Ser Gly Gly Ile Lys Tyr Lys Lys Ser Gly Lys Pro Glu Tyr Asn His 
            660                 665                 670         


Gln Arg Arg Asn Phe Ile Leu Asn Asn Val Leu Lys Ser Lys Trp Phe 
        675                 680                 685             


Phe Tyr Val Val Lys Tyr Asn Arg Pro Ser Ser Cys Arg Glu Leu Met 
    690                 695                 700                 


Lys Asn Lys Glu Ile Leu Arg Phe Val Leu Arg Asp Ile Pro Asp Ser 
705                 710                 715                 720 


Gln Val Arg Arg Tyr Phe Lys Ala Val Gln Gly Glu Glu Ala Tyr Ala 
                725                 730                 735     


Ser Ala Glu Ala Met Arg Thr Arg Leu Val Asp Ala Leu Ser Gln Phe 
            740                 745                 750         


Ser Val Thr Ala Cys Leu Asp Glu Val Gly Gly Met Thr Asp Lys Glu 
        755                 760                 765             


Phe Ala Ser Gln Arg Ala Val Asp Ser Lys Glu Lys Leu Arg Ala Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Leu Thr Val Ala Tyr Leu Ile Thr Lys Ser Met Val 
785                 790                 795                 800 


Lys Val Asn Thr Arg Phe Ser Ile Ala Phe Ser Val Leu Glu Arg Asp 
                805                 810                 815     


Tyr Tyr Leu Leu Ile Asp Gly Lys Lys Lys Ser Ser Asp Tyr Thr Gly 
            820                 825                 830         


Glu Asp Met Leu Ala Leu Thr Arg Lys Phe Val Gly Glu Asp Ala Gly 
        835                 840                 845             


Leu Tyr Arg Glu Trp Lys Glu Lys Asn Ala Glu Ala Lys Asp Lys Tyr 
    850                 855                 860                 


Phe Asp Lys Ala Glu Arg Lys Lys Val Leu Arg Gln Asn Asp Lys Met 
865                 870                 875                 880 


Ile Arg Lys Met His Phe Thr Pro His Ser Leu Asn Tyr Val Gln Lys 
                885                 890                 895     


Asn Leu Glu Ser Val Gln Ser Asn Gly Leu Ala Ala Val Ile Lys Glu 
            900                 905                 910         


Tyr Ala Asn Ala Val Ala Ala Leu Asn Ile Ile Asn Arg Leu Asp Glu 
        915                 920                 925             


Tyr Ile Gly Ser Ala Arg Ala Asp Ser Tyr Tyr Ser Leu Tyr Cys Tyr 
    930                 935                 940                 


Cys Leu Gln Met Tyr Leu Ser Lys Asn Phe Ser Val Gly Tyr Leu Ile 
945                 950                 955                 960 


Asn Val Gln Lys Gln Leu Glu Glu His His Thr Tyr Met Lys Asp Leu 
                965                 970                 975     


Met Trp Leu Leu Asn Ile Pro Phe Ala Tyr Asn Leu Ala Arg Tyr Lys 
            980                 985                 990         


Asn Leu Ser Asn Glu Lys Leu Phe  Tyr Asp Glu Glu Ala  Ala Ala Glu 
        995                 1000                 1005             


Lys Ala  Asp Lys Ala Glu Asn  Glu Arg Gly Glu 
    1010                 1015                 


<210>  584
<211>  4243
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  A01560 vector

<400>  584
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg tagccctgca gtaaggcagg gttctaagac cagcagcagc agcagcagca      300

gcagcatttt ttggtaccga tatcgtttaa acaggagtgg gaattggctc cggtgcccgt      360

cagtgggcag agcgcacatc gcccacagtc cccgagaagt tggggggagg ggtcggcaat      420

tgaaccggtg cctagagaag gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg      480

ctccgccttt ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac      540

gttctttttc gcaacgggtt tgccgccaga acacagaatt ccaggtaagt cccgcagccg      600

taacgacctt gggggggtgt gagattctca ttctaatttt gaagaatatt aggtgtaaaa      660

gcaagaaata caatgatcct gaggtgacac gcttatgttt tacttttaaa ctaggtgaaa      720

cgcgtgccgc caccatgaag aagaagcacc agagcgccgc cgagaagagg caagtgaaga      780

agctcaagaa tcaagagaag gcccagaagt acgctagcga gccttccccc ctccagagcg      840

atacagctgg cgtggaatgc tcccagaaaa agacagtcgt cagccacatt gccagctcca      900

agacactggc caaggctatg ggactcaaat ccacactggt catgggcgac aagctggtca      960

tcaccagctt tgctgctagc aaggctgtcg gaggcgctgg ctacaaaagc gctaacattg     1020

aaaaaatcac agatctgcaa ggaagggtca ttgaggagca cgaaaggatg tttagcgccg     1080

atgtcggaga gaaaaatatc gaactgagca agaatgactg ccacaccaac gtcaacaacc     1140

ccgtggtgac caacatcgga aaggattaca tcggactgaa atctaggctg gagcaagagt     1200

ttttcggcaa gacattcgag aatgacaatc tgcatgtgca gctggcctac aatatcctcg     1260

acatcaagaa aattctggga acctatgtga acaatatcat ttatatcttc tacaatctga     1320

atagggctgg caccggcaga gatgagagga tgtatgacga cctcatcggc acactgtacg     1380

cttacaaacc catggaggct caacagacct atctgctcaa aggcgacaag gatatgagga     1440

ggtttgagga ggtgaaacag ctgctgcaaa acacctccgc ttactatgtg tattacggca     1500

cactgttcga gaaggtgaag gctaagagca agaaggaaca gagggctaag gaggccgaaa     1560

tcgacgcttg taccgcccat aactacgatg tgctgagact gctgtccctc atggcgcagc     1620

tgtgcatggc ctccgtcgct ggaacagcct ttaagctggc tgagtccgct ctgttcaaca     1680

ttgaggatgt gctcagcgcc gatctgaagg aaatcctcga tgaagccttc tccggcgccg     1740

tgaacaagct caatgacgga ttcgtgcagc actccggcaa caatctgtac gtgctccagc     1800

agctgtaccc taatgagacc atcgagagaa tcgccgagaa gtactacaga ctcaccgtga     1860

ggaaggagga tctgaacatg ggagtcaaca ttaaaaagct gagggagctg atcgtgggcc     1920

aatactttcc cgaggtcctc gacaaagaat acgacctctc caagaatgga gacagcgtgg     1980

tgacatacag aagcaagatt tataccgtga tgaattacat tctgctgtat tacctcgagg     2040

accacgactc cagcagagaa agcatggtcg aagctctgag acaaaacaga gagggcgatg     2100

aaggcaagga ggagatctat agacagtttg ccaagaaggt gtggaacggc gtgtccggac     2160

tgtttggcgt gtgtctgaac ctcttcaaga ccgaaaagag aaacaagttt aggagcaaag     2220

tcgccctccc cgatgtgtcc ggcgctgcct atatgctctc ctccgagaac atcgactact     2280

ttgtcaagat gctcttcttt gtgtgtaagt ttctggatgg caaagaaatc aacgagctgc     2340

tgtgcgctct gatcaacaaa tttgataata ttgccgatat tctggatgct gccgctcaat     2400

gtggctcctc cgtctggttc gtggacagct ataggttctt cgagagatct aggaggatta     2460

gcgcccagat tagaatcgtg aagaacatcg cttccaagga ttttaagaaa tccaagaagg     2520

attccgatga gagctacccc gagcagctgt atctggatgc tctggctctg ctcggagacg     2580

tcatctccaa gtacaagcag aatagagatg gcagcgtcgt catcgatgac caaggcaatg     2640

ccgtgctgac agagcaatac aagaggttta gatatgaatt tttcgaggag atcaagaggg     2700

acgaaagcgg cggcatcaag tacaagaagt ccggaaaacc cgagtacaac catcagagaa     2760

ggaattttat tctgaataat gtgctgaaaa gcaaatggtt tttctatgtg gtgaagtaca     2820

ataggcccag cagctgcaga gaactgatga agaataagga aattctgagg ttcgtgctga     2880

gagacatccc cgactcccaa gtgagaagat actttaaggc cgtccaagga gaggaagctt     2940

acgctagcgc cgaagctatg aggacaagac tggtcgacgc tctgtcccaa tttagcgtca     3000

cagcttgtct ggatgaagtg ggcggcatga cagacaagga attcgcctcc cagagggccg     3060

tcgatagcaa agaaaaactg agagccatca tcagactgta tctgacagtc gcctatctga     3120

ttaccaagag catggtgaag gtgaatacaa ggtttagcat tgcctttagc gtgctggaga     3180

gggactacta tctgctcatt gacggcaaga agaaatccag cgactacacc ggagaggata     3240

tgctggctct gaccagaaaa tttgtgggcg aagatgctgg actgtataga gagtggaaag     3300

agaagaacgc tgaagccaag gacaaatatt ttgacaaggc cgaaaggaag aaggtgctga     3360

gacagaacga taagatgatc agaaagatgc acttcacacc ccactccctc aattacgtcc     3420

aaaagaatct cgaaagcgtc cagagcaacg gactggccgc cgtcatcaag gaatatgcaa     3480

atgccgtcgc tgccctcaat atcatcaata gactggacga gtacattggc tccgctaggg     3540

ctgatagcta ctactctctg tactgttact gcctccaaat gtatctgagc aagaacttca     3600

gcgtgggcta cctcatcaac gtgcaaaagc agctggagga gcaccacacc tacatgaagg     3660

atctcatgtg gctgctcaac atccccttcg cttacaacct cgccagatac aaaaatctgt     3720

ccaacgaaaa actcttttac gacgaggaag ccgccgccga aaaggctgac aaggctgaga     3780

acgagagagg cgaaggaagc cccaagaaga aaaggaaggt cggcggatct gagcagaaac     3840

tgattagcga agaggatctc taagcggccg cgataatcaa cctctggatt acaaaatttg     3900

tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg gatacgctgc     3960

tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct cctccttgta     4020

taaatcctgg ttagttcttg ccacggcgga actcatcgcc gcctgccttg cccgctgctg     4080

gacaggggct cggctgttgg gcactgacaa ttccgtgggt taacttgttt attgcagctt     4140

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     4200

tgcattctag ttgtggtttg tccaaactca tcaatgtatc tta                       4243


<210>  585
<211>  4587
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  A01560 vector with ITR

<400>  585
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccggtc gcgtctagta accggctagt tgatccgagc tgagggccta      180

tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga      240

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa      300

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc      360

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc      420

gtagccctgc agtaaggcag ggttctaaga ccagcagcag cagcagcagc agcagcattt      480

tttggtaccg atatcgttta aacaggagtg ggaattggct ccggtgcccg tcagtgggca      540

gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt      600

gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt      660

tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt      720

cgcaacgggt ttgccgccag aacacagaat tccaggtaag tcccgcagcc gtaacgacct      780

tgggggggtg tgagattctc attctaattt tgaagaatat taggtgtaaa agcaagaaat      840

acaatgatcc tgaggtgaca cgcttatgtt ttacttttaa actaggtgaa acgcgtgccg      900

ccaccatgaa gaagaagcac cagagcgccg ccgagaagag gcaagtgaag aagctcaaga      960

atcaagagaa ggcccagaag tacgctagcg agccttcccc cctccagagc gatacagctg     1020

gcgtggaatg ctcccagaaa aagacagtcg tcagccacat tgccagctcc aagacactgg     1080

ccaaggctat gggactcaaa tccacactgg tcatgggcga caagctggtc atcaccagct     1140

ttgctgctag caaggctgtc ggaggcgctg gctacaaaag cgctaacatt gaaaaaatca     1200

cagatctgca aggaagggtc attgaggagc acgaaaggat gtttagcgcc gatgtcggag     1260

agaaaaatat cgaactgagc aagaatgact gccacaccaa cgtcaacaac cccgtggtga     1320

ccaacatcgg aaaggattac atcggactga aatctaggct ggagcaagag tttttcggca     1380

agacattcga gaatgacaat ctgcatgtgc agctggccta caatatcctc gacatcaaga     1440

aaattctggg aacctatgtg aacaatatca tttatatctt ctacaatctg aatagggctg     1500

gcaccggcag agatgagagg atgtatgacg acctcatcgg cacactgtac gcttacaaac     1560

ccatggaggc tcaacagacc tatctgctca aaggcgacaa ggatatgagg aggtttgagg     1620

aggtgaaaca gctgctgcaa aacacctccg cttactatgt gtattacggc acactgttcg     1680

agaaggtgaa ggctaagagc aagaaggaac agagggctaa ggaggccgaa atcgacgctt     1740

gtaccgccca taactacgat gtgctgagac tgctgtccct catggcgcag ctgtgcatgg     1800

cctccgtcgc tggaacagcc tttaagctgg ctgagtccgc tctgttcaac attgaggatg     1860

tgctcagcgc cgatctgaag gaaatcctcg atgaagcctt ctccggcgcc gtgaacaagc     1920

tcaatgacgg attcgtgcag cactccggca acaatctgta cgtgctccag cagctgtacc     1980

ctaatgagac catcgagaga atcgccgaga agtactacag actcaccgtg aggaaggagg     2040

atctgaacat gggagtcaac attaaaaagc tgagggagct gatcgtgggc caatactttc     2100

ccgaggtcct cgacaaagaa tacgacctct ccaagaatgg agacagcgtg gtgacataca     2160

gaagcaagat ttataccgtg atgaattaca ttctgctgta ttacctcgag gaccacgact     2220

ccagcagaga aagcatggtc gaagctctga gacaaaacag agagggcgat gaaggcaagg     2280

aggagatcta tagacagttt gccaagaagg tgtggaacgg cgtgtccgga ctgtttggcg     2340

tgtgtctgaa cctcttcaag accgaaaaga gaaacaagtt taggagcaaa gtcgccctcc     2400

ccgatgtgtc cggcgctgcc tatatgctct cctccgagaa catcgactac tttgtcaaga     2460

tgctcttctt tgtgtgtaag tttctggatg gcaaagaaat caacgagctg ctgtgcgctc     2520

tgatcaacaa atttgataat attgccgata ttctggatgc tgccgctcaa tgtggctcct     2580

ccgtctggtt cgtggacagc tataggttct tcgagagatc taggaggatt agcgcccaga     2640

ttagaatcgt gaagaacatc gcttccaagg attttaagaa atccaagaag gattccgatg     2700

agagctaccc cgagcagctg tatctggatg ctctggctct gctcggagac gtcatctcca     2760

agtacaagca gaatagagat ggcagcgtcg tcatcgatga ccaaggcaat gccgtgctga     2820

cagagcaata caagaggttt agatatgaat ttttcgagga gatcaagagg gacgaaagcg     2880

gcggcatcaa gtacaagaag tccggaaaac ccgagtacaa ccatcagaga aggaatttta     2940

ttctgaataa tgtgctgaaa agcaaatggt ttttctatgt ggtgaagtac aataggccca     3000

gcagctgcag agaactgatg aagaataagg aaattctgag gttcgtgctg agagacatcc     3060

ccgactccca agtgagaaga tactttaagg ccgtccaagg agaggaagct tacgctagcg     3120

ccgaagctat gaggacaaga ctggtcgacg ctctgtccca atttagcgtc acagcttgtc     3180

tggatgaagt gggcggcatg acagacaagg aattcgcctc ccagagggcc gtcgatagca     3240

aagaaaaact gagagccatc atcagactgt atctgacagt cgcctatctg attaccaaga     3300

gcatggtgaa ggtgaataca aggtttagca ttgcctttag cgtgctggag agggactact     3360

atctgctcat tgacggcaag aagaaatcca gcgactacac cggagaggat atgctggctc     3420

tgaccagaaa atttgtgggc gaagatgctg gactgtatag agagtggaaa gagaagaacg     3480

ctgaagccaa ggacaaatat tttgacaagg ccgaaaggaa gaaggtgctg agacagaacg     3540

ataagatgat cagaaagatg cacttcacac cccactccct caattacgtc caaaagaatc     3600

tcgaaagcgt ccagagcaac ggactggccg ccgtcatcaa ggaatatgca aatgccgtcg     3660

ctgccctcaa tatcatcaat agactggacg agtacattgg ctccgctagg gctgatagct     3720

actactctct gtactgttac tgcctccaaa tgtatctgag caagaacttc agcgtgggct     3780

acctcatcaa cgtgcaaaag cagctggagg agcaccacac ctacatgaag gatctcatgt     3840

ggctgctcaa catccccttc gcttacaacc tcgccagata caaaaatctg tccaacgaaa     3900

aactctttta cgacgaggaa gccgccgccg aaaaggctga caaggctgag aacgagagag     3960

gcgaaggaag ccccaagaag aaaaggaagg tcggcggatc tgagcagaaa ctgattagcg     4020

aagaggatct ctaagcggcc gcgataatca acctctggat tacaaaattt gtgaaagatt     4080

gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc     4140

tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg     4200

gttagttctt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     4260

tcggctgttg ggcactgaca attccgtggg ttaacttgtt tattgcagct tataatggtt     4320

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     4380

gttgtggttt gtccaaactc atcaatgtat cttaacgcgg taaccacgtg cggacccaac     4440

ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     4500

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     4560

gcgagcgagc gcgcagctgc ctgcagg                                         4587


<210>  586
<211>  1019
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  dCas13d Seq212 H919A

<400>  586

Lys Lys Lys His Gln Ser Ala Ala Glu Lys Arg Gln Val Lys Lys Leu 
1               5                   10                  15      


Lys Asn Gln Glu Lys Ala Gln Lys Tyr Ala Ser Glu Pro Ser Pro Leu 
            20                  25                  30          


Gln Ser Asp Thr Ala Gly Val Glu Cys Ser Gln Lys Lys Thr Val Val 
        35                  40                  45              


Ser His Ile Ala Ser Ser Lys Thr Leu Ala Lys Ala Met Gly Leu Lys 
    50                  55                  60                  


Ser Thr Leu Val Met Gly Asp Lys Leu Val Ile Thr Ser Phe Ala Ala 
65                  70                  75                  80  


Ser Lys Ala Val Gly Gly Ala Gly Tyr Lys Ser Ala Asn Ile Glu Lys 
                85                  90                  95      


Ile Thr Asp Leu Gln Gly Arg Val Ile Glu Glu His Glu Arg Met Phe 
            100                 105                 110         


Ser Ala Asp Val Gly Glu Lys Asn Ile Glu Leu Ser Lys Asn Asp Cys 
        115                 120                 125             


His Thr Asn Val Asn Asn Pro Val Val Thr Asn Ile Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Gly Leu Lys Ser Arg Leu Glu Gln Glu Phe Phe Gly Lys Thr Phe 
145                 150                 155                 160 


Glu Asn Asp Asn Leu His Val Gln Leu Ala Tyr Asn Ile Leu Asp Ile 
                165                 170                 175     


Lys Lys Ile Leu Gly Thr Tyr Val Asn Asn Ile Ile Tyr Ile Phe Tyr 
            180                 185                 190         


Asn Leu Asn Arg Ala Gly Thr Gly Arg Asp Glu Arg Met Tyr Asp Asp 
        195                 200                 205             


Leu Ile Gly Thr Leu Tyr Ala Tyr Lys Pro Met Glu Ala Gln Gln Thr 
    210                 215                 220                 


Tyr Leu Leu Lys Gly Asp Lys Asp Met Arg Arg Phe Glu Glu Val Lys 
225                 230                 235                 240 


Gln Leu Leu Gln Asn Thr Ser Ala Tyr Tyr Val Tyr Tyr Gly Thr Leu 
                245                 250                 255     


Phe Glu Lys Val Lys Ala Lys Ser Lys Lys Glu Gln Arg Ala Lys Glu 
            260                 265                 270         


Ala Glu Ile Asp Ala Cys Thr Ala His Asn Tyr Asp Val Leu Arg Leu 
        275                 280                 285             


Leu Ser Leu Met Arg Gln Leu Cys Met His Ser Val Ala Gly Thr Ala 
    290                 295                 300                 


Phe Lys Leu Ala Glu Ser Ala Leu Phe Asn Ile Glu Asp Val Leu Ser 
305                 310                 315                 320 


Ala Asp Leu Lys Glu Ile Leu Asp Glu Ala Phe Ser Gly Ala Val Asn 
                325                 330                 335     


Lys Leu Asn Asp Gly Phe Val Gln His Ser Gly Asn Asn Leu Tyr Val 
            340                 345                 350         


Leu Gln Gln Leu Tyr Pro Asn Glu Thr Ile Glu Arg Ile Ala Glu Lys 
        355                 360                 365             


Tyr Tyr Arg Leu Thr Val Arg Lys Glu Asp Leu Asn Met Gly Val Asn 
    370                 375                 380                 


Ile Lys Lys Leu Arg Glu Leu Ile Val Gly Gln Tyr Phe Pro Glu Val 
385                 390                 395                 400 


Leu Asp Lys Glu Tyr Asp Leu Ser Lys Asn Gly Asp Ser Val Val Thr 
                405                 410                 415     


Tyr Arg Ser Lys Ile Tyr Thr Val Met Asn Tyr Ile Leu Leu Tyr Tyr 
            420                 425                 430         


Leu Glu Asp His Asp Ser Ser Arg Glu Ser Met Val Glu Ala Leu Arg 
        435                 440                 445             


Gln Asn Arg Glu Gly Asp Glu Gly Lys Glu Glu Ile Tyr Arg Gln Phe 
    450                 455                 460                 


Ala Lys Lys Val Trp Asn Gly Val Ser Gly Leu Phe Gly Val Cys Leu 
465                 470                 475                 480 


Asn Leu Phe Lys Thr Glu Lys Arg Asn Lys Phe Arg Ser Lys Val Ala 
                485                 490                 495     


Leu Pro Asp Val Ser Gly Ala Ala Tyr Met Leu Ser Ser Glu Asn Ile 
            500                 505                 510         


Asp Tyr Phe Val Lys Met Leu Phe Phe Val Cys Lys Phe Leu Asp Gly 
        515                 520                 525             


Lys Glu Ile Asn Glu Leu Leu Cys Ala Leu Ile Asn Lys Phe Asp Asn 
    530                 535                 540                 


Ile Ala Asp Ile Leu Asp Ala Ala Ala Gln Cys Gly Ser Ser Val Trp 
545                 550                 555                 560 


Phe Val Asp Ser Tyr Arg Phe Phe Glu Arg Ser Arg Arg Ile Ser Ala 
                565                 570                 575     


Gln Ile Arg Ile Val Lys Asn Ile Ala Ser Lys Asp Phe Lys Lys Ser 
            580                 585                 590         


Lys Lys Asp Ser Asp Glu Ser Tyr Pro Glu Gln Leu Tyr Leu Asp Ala 
        595                 600                 605             


Leu Ala Leu Leu Gly Asp Val Ile Ser Lys Tyr Lys Gln Asn Arg Asp 
    610                 615                 620                 


Gly Ser Val Val Ile Asp Asp Gln Gly Asn Ala Val Leu Thr Glu Gln 
625                 630                 635                 640 


Tyr Lys Arg Phe Arg Tyr Glu Phe Phe Glu Glu Ile Lys Arg Asp Glu 
                645                 650                 655     


Ser Gly Gly Ile Lys Tyr Lys Lys Ser Gly Lys Pro Glu Tyr Asn His 
            660                 665                 670         


Gln Arg Arg Asn Phe Ile Leu Asn Asn Val Leu Lys Ser Lys Trp Phe 
        675                 680                 685             


Phe Tyr Val Val Lys Tyr Asn Arg Pro Ser Ser Cys Arg Glu Leu Met 
    690                 695                 700                 


Lys Asn Lys Glu Ile Leu Arg Phe Val Leu Arg Asp Ile Pro Asp Ser 
705                 710                 715                 720 


Gln Val Arg Arg Tyr Phe Lys Ala Val Gln Gly Glu Glu Ala Tyr Ala 
                725                 730                 735     


Ser Ala Glu Ala Met Arg Thr Arg Leu Val Asp Ala Leu Ser Gln Phe 
            740                 745                 750         


Ser Val Thr Ala Cys Leu Asp Glu Val Gly Gly Met Thr Asp Lys Glu 
        755                 760                 765             


Phe Ala Ser Gln Arg Ala Val Asp Ser Lys Glu Lys Leu Arg Ala Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Leu Thr Val Ala Tyr Leu Ile Thr Lys Ser Met Val 
785                 790                 795                 800 


Lys Val Asn Thr Arg Phe Ser Ile Ala Phe Ser Val Leu Glu Arg Asp 
                805                 810                 815     


Tyr Tyr Leu Leu Ile Asp Gly Lys Lys Lys Ser Ser Asp Tyr Thr Gly 
            820                 825                 830         


Glu Asp Met Leu Ala Leu Thr Arg Lys Phe Val Gly Glu Asp Ala Gly 
        835                 840                 845             


Leu Tyr Arg Glu Trp Lys Glu Lys Asn Ala Glu Ala Lys Asp Lys Tyr 
    850                 855                 860                 


Phe Asp Lys Ala Glu Arg Lys Lys Val Leu Arg Gln Asn Asp Lys Met 
865                 870                 875                 880 


Ile Arg Lys Met His Phe Thr Pro His Ser Leu Asn Tyr Val Gln Lys 
                885                 890                 895     


Asn Leu Glu Ser Val Gln Ser Asn Gly Leu Ala Ala Val Ile Lys Glu 
            900                 905                 910         


Tyr Arg Asn Ala Val Ala Ala Leu Asn Ile Ile Asn Arg Leu Asp Glu 
        915                 920                 925             


Tyr Ile Gly Ser Ala Arg Ala Asp Ser Tyr Tyr Ser Leu Tyr Cys Tyr 
    930                 935                 940                 


Cys Leu Gln Met Tyr Leu Ser Lys Asn Phe Ser Val Gly Tyr Leu Ile 
945                 950                 955                 960 


Asn Val Gln Lys Gln Leu Glu Glu His His Thr Tyr Met Lys Asp Leu 
                965                 970                 975     


Met Trp Leu Leu Asn Ile Pro Phe Ala Tyr Asn Leu Ala Arg Tyr Lys 
            980                 985                 990         


Asn Leu Ser Asn Glu Lys Leu Phe  Tyr Asp Glu Glu Ala  Ala Ala Glu 
        995                 1000                 1005             


Lys Ala  Asp Lys Ala Glu Asn  Glu Arg Gly Glu 
    1010                 1015                 


<210>  587
<211>  1019
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  dCas13d Seq212 R914A

<400>  587

Lys Lys Lys His Gln Ser Ala Ala Glu Lys Arg Gln Val Lys Lys Leu 
1               5                   10                  15      


Lys Asn Gln Glu Lys Ala Gln Lys Tyr Ala Ser Glu Pro Ser Pro Leu 
            20                  25                  30          


Gln Ser Asp Thr Ala Gly Val Glu Cys Ser Gln Lys Lys Thr Val Val 
        35                  40                  45              


Ser His Ile Ala Ser Ser Lys Thr Leu Ala Lys Ala Met Gly Leu Lys 
    50                  55                  60                  


Ser Thr Leu Val Met Gly Asp Lys Leu Val Ile Thr Ser Phe Ala Ala 
65                  70                  75                  80  


Ser Lys Ala Val Gly Gly Ala Gly Tyr Lys Ser Ala Asn Ile Glu Lys 
                85                  90                  95      


Ile Thr Asp Leu Gln Gly Arg Val Ile Glu Glu His Glu Arg Met Phe 
            100                 105                 110         


Ser Ala Asp Val Gly Glu Lys Asn Ile Glu Leu Ser Lys Asn Asp Cys 
        115                 120                 125             


His Thr Asn Val Asn Asn Pro Val Val Thr Asn Ile Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Gly Leu Lys Ser Arg Leu Glu Gln Glu Phe Phe Gly Lys Thr Phe 
145                 150                 155                 160 


Glu Asn Asp Asn Leu His Val Gln Leu Ala Tyr Asn Ile Leu Asp Ile 
                165                 170                 175     


Lys Lys Ile Leu Gly Thr Tyr Val Asn Asn Ile Ile Tyr Ile Phe Tyr 
            180                 185                 190         


Asn Leu Asn Arg Ala Gly Thr Gly Arg Asp Glu Arg Met Tyr Asp Asp 
        195                 200                 205             


Leu Ile Gly Thr Leu Tyr Ala Tyr Lys Pro Met Glu Ala Gln Gln Thr 
    210                 215                 220                 


Tyr Leu Leu Lys Gly Asp Lys Asp Met Arg Arg Phe Glu Glu Val Lys 
225                 230                 235                 240 


Gln Leu Leu Gln Asn Thr Ser Ala Tyr Tyr Val Tyr Tyr Gly Thr Leu 
                245                 250                 255     


Phe Glu Lys Val Lys Ala Lys Ser Lys Lys Glu Gln Arg Ala Lys Glu 
            260                 265                 270         


Ala Glu Ile Asp Ala Cys Thr Ala His Asn Tyr Asp Val Leu Arg Leu 
        275                 280                 285             


Leu Ser Leu Met Arg Gln Leu Cys Met His Ser Val Ala Gly Thr Ala 
    290                 295                 300                 


Phe Lys Leu Ala Glu Ser Ala Leu Phe Asn Ile Glu Asp Val Leu Ser 
305                 310                 315                 320 


Ala Asp Leu Lys Glu Ile Leu Asp Glu Ala Phe Ser Gly Ala Val Asn 
                325                 330                 335     


Lys Leu Asn Asp Gly Phe Val Gln His Ser Gly Asn Asn Leu Tyr Val 
            340                 345                 350         


Leu Gln Gln Leu Tyr Pro Asn Glu Thr Ile Glu Arg Ile Ala Glu Lys 
        355                 360                 365             


Tyr Tyr Arg Leu Thr Val Arg Lys Glu Asp Leu Asn Met Gly Val Asn 
    370                 375                 380                 


Ile Lys Lys Leu Arg Glu Leu Ile Val Gly Gln Tyr Phe Pro Glu Val 
385                 390                 395                 400 


Leu Asp Lys Glu Tyr Asp Leu Ser Lys Asn Gly Asp Ser Val Val Thr 
                405                 410                 415     


Tyr Arg Ser Lys Ile Tyr Thr Val Met Asn Tyr Ile Leu Leu Tyr Tyr 
            420                 425                 430         


Leu Glu Asp His Asp Ser Ser Arg Glu Ser Met Val Glu Ala Leu Arg 
        435                 440                 445             


Gln Asn Arg Glu Gly Asp Glu Gly Lys Glu Glu Ile Tyr Arg Gln Phe 
    450                 455                 460                 


Ala Lys Lys Val Trp Asn Gly Val Ser Gly Leu Phe Gly Val Cys Leu 
465                 470                 475                 480 


Asn Leu Phe Lys Thr Glu Lys Arg Asn Lys Phe Arg Ser Lys Val Ala 
                485                 490                 495     


Leu Pro Asp Val Ser Gly Ala Ala Tyr Met Leu Ser Ser Glu Asn Ile 
            500                 505                 510         


Asp Tyr Phe Val Lys Met Leu Phe Phe Val Cys Lys Phe Leu Asp Gly 
        515                 520                 525             


Lys Glu Ile Asn Glu Leu Leu Cys Ala Leu Ile Asn Lys Phe Asp Asn 
    530                 535                 540                 


Ile Ala Asp Ile Leu Asp Ala Ala Ala Gln Cys Gly Ser Ser Val Trp 
545                 550                 555                 560 


Phe Val Asp Ser Tyr Arg Phe Phe Glu Arg Ser Arg Arg Ile Ser Ala 
                565                 570                 575     


Gln Ile Arg Ile Val Lys Asn Ile Ala Ser Lys Asp Phe Lys Lys Ser 
            580                 585                 590         


Lys Lys Asp Ser Asp Glu Ser Tyr Pro Glu Gln Leu Tyr Leu Asp Ala 
        595                 600                 605             


Leu Ala Leu Leu Gly Asp Val Ile Ser Lys Tyr Lys Gln Asn Arg Asp 
    610                 615                 620                 


Gly Ser Val Val Ile Asp Asp Gln Gly Asn Ala Val Leu Thr Glu Gln 
625                 630                 635                 640 


Tyr Lys Arg Phe Arg Tyr Glu Phe Phe Glu Glu Ile Lys Arg Asp Glu 
                645                 650                 655     


Ser Gly Gly Ile Lys Tyr Lys Lys Ser Gly Lys Pro Glu Tyr Asn His 
            660                 665                 670         


Gln Arg Arg Asn Phe Ile Leu Asn Asn Val Leu Lys Ser Lys Trp Phe 
        675                 680                 685             


Phe Tyr Val Val Lys Tyr Asn Arg Pro Ser Ser Cys Arg Glu Leu Met 
    690                 695                 700                 


Lys Asn Lys Glu Ile Leu Arg Phe Val Leu Arg Asp Ile Pro Asp Ser 
705                 710                 715                 720 


Gln Val Arg Arg Tyr Phe Lys Ala Val Gln Gly Glu Glu Ala Tyr Ala 
                725                 730                 735     


Ser Ala Glu Ala Met Arg Thr Arg Leu Val Asp Ala Leu Ser Gln Phe 
            740                 745                 750         


Ser Val Thr Ala Cys Leu Asp Glu Val Gly Gly Met Thr Asp Lys Glu 
        755                 760                 765             


Phe Ala Ser Gln Arg Ala Val Asp Ser Lys Glu Lys Leu Arg Ala Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Leu Thr Val Ala Tyr Leu Ile Thr Lys Ser Met Val 
785                 790                 795                 800 


Lys Val Asn Thr Arg Phe Ser Ile Ala Phe Ser Val Leu Glu Arg Asp 
                805                 810                 815     


Tyr Tyr Leu Leu Ile Asp Gly Lys Lys Lys Ser Ser Asp Tyr Thr Gly 
            820                 825                 830         


Glu Asp Met Leu Ala Leu Thr Arg Lys Phe Val Gly Glu Asp Ala Gly 
        835                 840                 845             


Leu Tyr Arg Glu Trp Lys Glu Lys Asn Ala Glu Ala Lys Asp Lys Tyr 
    850                 855                 860                 


Phe Asp Lys Ala Glu Arg Lys Lys Val Leu Arg Gln Asn Asp Lys Met 
865                 870                 875                 880 


Ile Arg Lys Met His Phe Thr Pro His Ser Leu Asn Tyr Val Gln Lys 
                885                 890                 895     


Asn Leu Glu Ser Val Gln Ser Asn Gly Leu Ala Ala Val Ile Lys Glu 
            900                 905                 910         


Tyr Ala Asn Ala Val Ala His Leu Asn Ile Ile Asn Arg Leu Asp Glu 
        915                 920                 925             


Tyr Ile Gly Ser Ala Arg Ala Asp Ser Tyr Tyr Ser Leu Tyr Cys Tyr 
    930                 935                 940                 


Cys Leu Gln Met Tyr Leu Ser Lys Asn Phe Ser Val Gly Tyr Leu Ile 
945                 950                 955                 960 


Asn Val Gln Lys Gln Leu Glu Glu His His Thr Tyr Met Lys Asp Leu 
                965                 970                 975     


Met Trp Leu Leu Asn Ile Pro Phe Ala Tyr Asn Leu Ala Arg Tyr Lys 
            980                 985                 990         


Asn Leu Ser Asn Glu Lys Leu Phe  Tyr Asp Glu Glu Ala  Ala Ala Glu 
        995                 1000                 1005             


Lys Ala  Asp Lys Ala Glu Asn  Glu Arg Gly Glu 
    1010                 1015                 


<210>  588
<211>  1019
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  dCas13d Seq212 R293A

<400>  588

Lys Lys Lys His Gln Ser Ala Ala Glu Lys Arg Gln Val Lys Lys Leu 
1               5                   10                  15      


Lys Asn Gln Glu Lys Ala Gln Lys Tyr Ala Ser Glu Pro Ser Pro Leu 
            20                  25                  30          


Gln Ser Asp Thr Ala Gly Val Glu Cys Ser Gln Lys Lys Thr Val Val 
        35                  40                  45              


Ser His Ile Ala Ser Ser Lys Thr Leu Ala Lys Ala Met Gly Leu Lys 
    50                  55                  60                  


Ser Thr Leu Val Met Gly Asp Lys Leu Val Ile Thr Ser Phe Ala Ala 
65                  70                  75                  80  


Ser Lys Ala Val Gly Gly Ala Gly Tyr Lys Ser Ala Asn Ile Glu Lys 
                85                  90                  95      


Ile Thr Asp Leu Gln Gly Arg Val Ile Glu Glu His Glu Arg Met Phe 
            100                 105                 110         


Ser Ala Asp Val Gly Glu Lys Asn Ile Glu Leu Ser Lys Asn Asp Cys 
        115                 120                 125             


His Thr Asn Val Asn Asn Pro Val Val Thr Asn Ile Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Gly Leu Lys Ser Arg Leu Glu Gln Glu Phe Phe Gly Lys Thr Phe 
145                 150                 155                 160 


Glu Asn Asp Asn Leu His Val Gln Leu Ala Tyr Asn Ile Leu Asp Ile 
                165                 170                 175     


Lys Lys Ile Leu Gly Thr Tyr Val Asn Asn Ile Ile Tyr Ile Phe Tyr 
            180                 185                 190         


Asn Leu Asn Arg Ala Gly Thr Gly Arg Asp Glu Arg Met Tyr Asp Asp 
        195                 200                 205             


Leu Ile Gly Thr Leu Tyr Ala Tyr Lys Pro Met Glu Ala Gln Gln Thr 
    210                 215                 220                 


Tyr Leu Leu Lys Gly Asp Lys Asp Met Arg Arg Phe Glu Glu Val Lys 
225                 230                 235                 240 


Gln Leu Leu Gln Asn Thr Ser Ala Tyr Tyr Val Tyr Tyr Gly Thr Leu 
                245                 250                 255     


Phe Glu Lys Val Lys Ala Lys Ser Lys Lys Glu Gln Arg Ala Lys Glu 
            260                 265                 270         


Ala Glu Ile Asp Ala Cys Thr Ala His Asn Tyr Asp Val Leu Arg Leu 
        275                 280                 285             


Leu Ser Leu Met Ala Gln Leu Cys Met His Ser Val Ala Gly Thr Ala 
    290                 295                 300                 


Phe Lys Leu Ala Glu Ser Ala Leu Phe Asn Ile Glu Asp Val Leu Ser 
305                 310                 315                 320 


Ala Asp Leu Lys Glu Ile Leu Asp Glu Ala Phe Ser Gly Ala Val Asn 
                325                 330                 335     


Lys Leu Asn Asp Gly Phe Val Gln His Ser Gly Asn Asn Leu Tyr Val 
            340                 345                 350         


Leu Gln Gln Leu Tyr Pro Asn Glu Thr Ile Glu Arg Ile Ala Glu Lys 
        355                 360                 365             


Tyr Tyr Arg Leu Thr Val Arg Lys Glu Asp Leu Asn Met Gly Val Asn 
    370                 375                 380                 


Ile Lys Lys Leu Arg Glu Leu Ile Val Gly Gln Tyr Phe Pro Glu Val 
385                 390                 395                 400 


Leu Asp Lys Glu Tyr Asp Leu Ser Lys Asn Gly Asp Ser Val Val Thr 
                405                 410                 415     


Tyr Arg Ser Lys Ile Tyr Thr Val Met Asn Tyr Ile Leu Leu Tyr Tyr 
            420                 425                 430         


Leu Glu Asp His Asp Ser Ser Arg Glu Ser Met Val Glu Ala Leu Arg 
        435                 440                 445             


Gln Asn Arg Glu Gly Asp Glu Gly Lys Glu Glu Ile Tyr Arg Gln Phe 
    450                 455                 460                 


Ala Lys Lys Val Trp Asn Gly Val Ser Gly Leu Phe Gly Val Cys Leu 
465                 470                 475                 480 


Asn Leu Phe Lys Thr Glu Lys Arg Asn Lys Phe Arg Ser Lys Val Ala 
                485                 490                 495     


Leu Pro Asp Val Ser Gly Ala Ala Tyr Met Leu Ser Ser Glu Asn Ile 
            500                 505                 510         


Asp Tyr Phe Val Lys Met Leu Phe Phe Val Cys Lys Phe Leu Asp Gly 
        515                 520                 525             


Lys Glu Ile Asn Glu Leu Leu Cys Ala Leu Ile Asn Lys Phe Asp Asn 
    530                 535                 540                 


Ile Ala Asp Ile Leu Asp Ala Ala Ala Gln Cys Gly Ser Ser Val Trp 
545                 550                 555                 560 


Phe Val Asp Ser Tyr Arg Phe Phe Glu Arg Ser Arg Arg Ile Ser Ala 
                565                 570                 575     


Gln Ile Arg Ile Val Lys Asn Ile Ala Ser Lys Asp Phe Lys Lys Ser 
            580                 585                 590         


Lys Lys Asp Ser Asp Glu Ser Tyr Pro Glu Gln Leu Tyr Leu Asp Ala 
        595                 600                 605             


Leu Ala Leu Leu Gly Asp Val Ile Ser Lys Tyr Lys Gln Asn Arg Asp 
    610                 615                 620                 


Gly Ser Val Val Ile Asp Asp Gln Gly Asn Ala Val Leu Thr Glu Gln 
625                 630                 635                 640 


Tyr Lys Arg Phe Arg Tyr Glu Phe Phe Glu Glu Ile Lys Arg Asp Glu 
                645                 650                 655     


Ser Gly Gly Ile Lys Tyr Lys Lys Ser Gly Lys Pro Glu Tyr Asn His 
            660                 665                 670         


Gln Arg Arg Asn Phe Ile Leu Asn Asn Val Leu Lys Ser Lys Trp Phe 
        675                 680                 685             


Phe Tyr Val Val Lys Tyr Asn Arg Pro Ser Ser Cys Arg Glu Leu Met 
    690                 695                 700                 


Lys Asn Lys Glu Ile Leu Arg Phe Val Leu Arg Asp Ile Pro Asp Ser 
705                 710                 715                 720 


Gln Val Arg Arg Tyr Phe Lys Ala Val Gln Gly Glu Glu Ala Tyr Ala 
                725                 730                 735     


Ser Ala Glu Ala Met Arg Thr Arg Leu Val Asp Ala Leu Ser Gln Phe 
            740                 745                 750         


Ser Val Thr Ala Cys Leu Asp Glu Val Gly Gly Met Thr Asp Lys Glu 
        755                 760                 765             


Phe Ala Ser Gln Arg Ala Val Asp Ser Lys Glu Lys Leu Arg Ala Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Leu Thr Val Ala Tyr Leu Ile Thr Lys Ser Met Val 
785                 790                 795                 800 


Lys Val Asn Thr Arg Phe Ser Ile Ala Phe Ser Val Leu Glu Arg Asp 
                805                 810                 815     


Tyr Tyr Leu Leu Ile Asp Gly Lys Lys Lys Ser Ser Asp Tyr Thr Gly 
            820                 825                 830         


Glu Asp Met Leu Ala Leu Thr Arg Lys Phe Val Gly Glu Asp Ala Gly 
        835                 840                 845             


Leu Tyr Arg Glu Trp Lys Glu Lys Asn Ala Glu Ala Lys Asp Lys Tyr 
    850                 855                 860                 


Phe Asp Lys Ala Glu Arg Lys Lys Val Leu Arg Gln Asn Asp Lys Met 
865                 870                 875                 880 


Ile Arg Lys Met His Phe Thr Pro His Ser Leu Asn Tyr Val Gln Lys 
                885                 890                 895     


Asn Leu Glu Ser Val Gln Ser Asn Gly Leu Ala Ala Val Ile Lys Glu 
            900                 905                 910         


Tyr Arg Asn Ala Val Ala His Leu Asn Ile Ile Asn Arg Leu Asp Glu 
        915                 920                 925             


Tyr Ile Gly Ser Ala Arg Ala Asp Ser Tyr Tyr Ser Leu Tyr Cys Tyr 
    930                 935                 940                 


Cys Leu Gln Met Tyr Leu Ser Lys Asn Phe Ser Val Gly Tyr Leu Ile 
945                 950                 955                 960 


Asn Val Gln Lys Gln Leu Glu Glu His His Thr Tyr Met Lys Asp Leu 
                965                 970                 975     


Met Trp Leu Leu Asn Ile Pro Phe Ala Tyr Asn Leu Ala Arg Tyr Lys 
            980                 985                 990         


Asn Leu Ser Asn Glu Lys Leu Phe  Tyr Asp Glu Glu Ala  Ala Ala Glu 
        995                 1000                 1005             


Lys Ala  Asp Lys Ala Glu Asn  Glu Arg Gly Glu 
    1010                 1015                 


<210>  589
<211>  1019
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  dCas13d Seq212 H298A

<400>  589

Lys Lys Lys His Gln Ser Ala Ala Glu Lys Arg Gln Val Lys Lys Leu 
1               5                   10                  15      


Lys Asn Gln Glu Lys Ala Gln Lys Tyr Ala Ser Glu Pro Ser Pro Leu 
            20                  25                  30          


Gln Ser Asp Thr Ala Gly Val Glu Cys Ser Gln Lys Lys Thr Val Val 
        35                  40                  45              


Ser His Ile Ala Ser Ser Lys Thr Leu Ala Lys Ala Met Gly Leu Lys 
    50                  55                  60                  


Ser Thr Leu Val Met Gly Asp Lys Leu Val Ile Thr Ser Phe Ala Ala 
65                  70                  75                  80  


Ser Lys Ala Val Gly Gly Ala Gly Tyr Lys Ser Ala Asn Ile Glu Lys 
                85                  90                  95      


Ile Thr Asp Leu Gln Gly Arg Val Ile Glu Glu His Glu Arg Met Phe 
            100                 105                 110         


Ser Ala Asp Val Gly Glu Lys Asn Ile Glu Leu Ser Lys Asn Asp Cys 
        115                 120                 125             


His Thr Asn Val Asn Asn Pro Val Val Thr Asn Ile Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Gly Leu Lys Ser Arg Leu Glu Gln Glu Phe Phe Gly Lys Thr Phe 
145                 150                 155                 160 


Glu Asn Asp Asn Leu His Val Gln Leu Ala Tyr Asn Ile Leu Asp Ile 
                165                 170                 175     


Lys Lys Ile Leu Gly Thr Tyr Val Asn Asn Ile Ile Tyr Ile Phe Tyr 
            180                 185                 190         


Asn Leu Asn Arg Ala Gly Thr Gly Arg Asp Glu Arg Met Tyr Asp Asp 
        195                 200                 205             


Leu Ile Gly Thr Leu Tyr Ala Tyr Lys Pro Met Glu Ala Gln Gln Thr 
    210                 215                 220                 


Tyr Leu Leu Lys Gly Asp Lys Asp Met Arg Arg Phe Glu Glu Val Lys 
225                 230                 235                 240 


Gln Leu Leu Gln Asn Thr Ser Ala Tyr Tyr Val Tyr Tyr Gly Thr Leu 
                245                 250                 255     


Phe Glu Lys Val Lys Ala Lys Ser Lys Lys Glu Gln Arg Ala Lys Glu 
            260                 265                 270         


Ala Glu Ile Asp Ala Cys Thr Ala His Asn Tyr Asp Val Leu Arg Leu 
        275                 280                 285             


Leu Ser Leu Met Arg Gln Leu Cys Met Ala Ser Val Ala Gly Thr Ala 
    290                 295                 300                 


Phe Lys Leu Ala Glu Ser Ala Leu Phe Asn Ile Glu Asp Val Leu Ser 
305                 310                 315                 320 


Ala Asp Leu Lys Glu Ile Leu Asp Glu Ala Phe Ser Gly Ala Val Asn 
                325                 330                 335     


Lys Leu Asn Asp Gly Phe Val Gln His Ser Gly Asn Asn Leu Tyr Val 
            340                 345                 350         


Leu Gln Gln Leu Tyr Pro Asn Glu Thr Ile Glu Arg Ile Ala Glu Lys 
        355                 360                 365             


Tyr Tyr Arg Leu Thr Val Arg Lys Glu Asp Leu Asn Met Gly Val Asn 
    370                 375                 380                 


Ile Lys Lys Leu Arg Glu Leu Ile Val Gly Gln Tyr Phe Pro Glu Val 
385                 390                 395                 400 


Leu Asp Lys Glu Tyr Asp Leu Ser Lys Asn Gly Asp Ser Val Val Thr 
                405                 410                 415     


Tyr Arg Ser Lys Ile Tyr Thr Val Met Asn Tyr Ile Leu Leu Tyr Tyr 
            420                 425                 430         


Leu Glu Asp His Asp Ser Ser Arg Glu Ser Met Val Glu Ala Leu Arg 
        435                 440                 445             


Gln Asn Arg Glu Gly Asp Glu Gly Lys Glu Glu Ile Tyr Arg Gln Phe 
    450                 455                 460                 


Ala Lys Lys Val Trp Asn Gly Val Ser Gly Leu Phe Gly Val Cys Leu 
465                 470                 475                 480 


Asn Leu Phe Lys Thr Glu Lys Arg Asn Lys Phe Arg Ser Lys Val Ala 
                485                 490                 495     


Leu Pro Asp Val Ser Gly Ala Ala Tyr Met Leu Ser Ser Glu Asn Ile 
            500                 505                 510         


Asp Tyr Phe Val Lys Met Leu Phe Phe Val Cys Lys Phe Leu Asp Gly 
        515                 520                 525             


Lys Glu Ile Asn Glu Leu Leu Cys Ala Leu Ile Asn Lys Phe Asp Asn 
    530                 535                 540                 


Ile Ala Asp Ile Leu Asp Ala Ala Ala Gln Cys Gly Ser Ser Val Trp 
545                 550                 555                 560 


Phe Val Asp Ser Tyr Arg Phe Phe Glu Arg Ser Arg Arg Ile Ser Ala 
                565                 570                 575     


Gln Ile Arg Ile Val Lys Asn Ile Ala Ser Lys Asp Phe Lys Lys Ser 
            580                 585                 590         


Lys Lys Asp Ser Asp Glu Ser Tyr Pro Glu Gln Leu Tyr Leu Asp Ala 
        595                 600                 605             


Leu Ala Leu Leu Gly Asp Val Ile Ser Lys Tyr Lys Gln Asn Arg Asp 
    610                 615                 620                 


Gly Ser Val Val Ile Asp Asp Gln Gly Asn Ala Val Leu Thr Glu Gln 
625                 630                 635                 640 


Tyr Lys Arg Phe Arg Tyr Glu Phe Phe Glu Glu Ile Lys Arg Asp Glu 
                645                 650                 655     


Ser Gly Gly Ile Lys Tyr Lys Lys Ser Gly Lys Pro Glu Tyr Asn His 
            660                 665                 670         


Gln Arg Arg Asn Phe Ile Leu Asn Asn Val Leu Lys Ser Lys Trp Phe 
        675                 680                 685             


Phe Tyr Val Val Lys Tyr Asn Arg Pro Ser Ser Cys Arg Glu Leu Met 
    690                 695                 700                 


Lys Asn Lys Glu Ile Leu Arg Phe Val Leu Arg Asp Ile Pro Asp Ser 
705                 710                 715                 720 


Gln Val Arg Arg Tyr Phe Lys Ala Val Gln Gly Glu Glu Ala Tyr Ala 
                725                 730                 735     


Ser Ala Glu Ala Met Arg Thr Arg Leu Val Asp Ala Leu Ser Gln Phe 
            740                 745                 750         


Ser Val Thr Ala Cys Leu Asp Glu Val Gly Gly Met Thr Asp Lys Glu 
        755                 760                 765             


Phe Ala Ser Gln Arg Ala Val Asp Ser Lys Glu Lys Leu Arg Ala Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Leu Thr Val Ala Tyr Leu Ile Thr Lys Ser Met Val 
785                 790                 795                 800 


Lys Val Asn Thr Arg Phe Ser Ile Ala Phe Ser Val Leu Glu Arg Asp 
                805                 810                 815     


Tyr Tyr Leu Leu Ile Asp Gly Lys Lys Lys Ser Ser Asp Tyr Thr Gly 
            820                 825                 830         


Glu Asp Met Leu Ala Leu Thr Arg Lys Phe Val Gly Glu Asp Ala Gly 
        835                 840                 845             


Leu Tyr Arg Glu Trp Lys Glu Lys Asn Ala Glu Ala Lys Asp Lys Tyr 
    850                 855                 860                 


Phe Asp Lys Ala Glu Arg Lys Lys Val Leu Arg Gln Asn Asp Lys Met 
865                 870                 875                 880 


Ile Arg Lys Met His Phe Thr Pro His Ser Leu Asn Tyr Val Gln Lys 
                885                 890                 895     


Asn Leu Glu Ser Val Gln Ser Asn Gly Leu Ala Ala Val Ile Lys Glu 
            900                 905                 910         


Tyr Arg Asn Ala Val Ala His Leu Asn Ile Ile Asn Arg Leu Asp Glu 
        915                 920                 925             


Tyr Ile Gly Ser Ala Arg Ala Asp Ser Tyr Tyr Ser Leu Tyr Cys Tyr 
    930                 935                 940                 


Cys Leu Gln Met Tyr Leu Ser Lys Asn Phe Ser Val Gly Tyr Leu Ile 
945                 950                 955                 960 


Asn Val Gln Lys Gln Leu Glu Glu His His Thr Tyr Met Lys Asp Leu 
                965                 970                 975     


Met Trp Leu Leu Asn Ile Pro Phe Ala Tyr Asn Leu Ala Arg Tyr Lys 
            980                 985                 990         


Asn Leu Ser Asn Glu Lys Leu Phe  Tyr Asp Glu Glu Ala  Ala Ala Glu 
        995                 1000                 1005             


Lys Ala  Asp Lys Ala Glu Asn  Glu Arg Gly Glu 
    1010                 1015                 


<210>  590
<211>  4243
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  dCas13d AAV vector

<400>  590
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg tagccctgca gtaaggcagg gttctaagac cagcagcagc agcagcagca      300

gcagcatttt ttggtaccga tatcgtttaa acaggagtgg gaattggctc cggtgcccgt      360

cagtgggcag agcgcacatc gcccacagtc cccgagaagt tggggggagg ggtcggcaat      420

tgaaccggtg cctagagaag gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg      480

ctccgccttt ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac      540

gttctttttc gcaacgggtt tgccgccaga acacagaatt ccaggtaagt cccgcagccg      600

taacgacctt gggggggtgt gagattctca ttctaatttt gaagaatatt aggtgtaaaa      660

gcaagaaata caatgatcct gaggtgacac gcttatgttt tacttttaaa ctaggtgaaa      720

cgcgtgccgc caccatgaag aagaagcacc agagcgccgc cgagaagagg caagtgaaga      780

agctcaagaa tcaagagaag gcccagaagt acgctagcga gccttccccc ctccagagcg      840

atacagctgg cgtggaatgc tcccagaaaa agacagtcgt cagccacatt gccagctcca      900

agacactggc caaggctatg ggactcaaat ccacactggt catgggcgac aagctggtca      960

tcaccagctt tgctgctagc aaggctgtcg gaggcgctgg ctacaaaagc gctaacattg     1020

aaaaaatcac agatctgcaa ggaagggtca ttgaggagca cgaaaggatg tttagcgccg     1080

atgtcggaga gaaaaatatc gaactgagca agaatgactg ccacaccaac gtcaacaacc     1140

ccgtggtgac caacatcgga aaggattaca tcggactgaa atctaggctg gagcaagagt     1200

ttttcggcaa gacattcgag aatgacaatc tgcatgtgca gctggcctac aatatcctcg     1260

acatcaagaa aattctggga acctatgtga acaatatcat ttatatcttc tacaatctga     1320

atagggctgg caccggcaga gatgagagga tgtatgacga cctcatcggc acactgtacg     1380

cttacaaacc catggaggct caacagacct atctgctcaa aggcgacaag gatatgagga     1440

ggtttgagga ggtgaaacag ctgctgcaaa acacctccgc ttactatgtg tattacggca     1500

cactgttcga gaaggtgaag gctaagagca agaaggaaca gagggctaag gaggccgaaa     1560

tcgacgcttg taccgcccat aactacgatg tgctgagact gctgtccctc atgaggcagc     1620

tgtgcatgca ctccgtcgct ggaacagcct ttaagctggc tgagtccgct ctgttcaaca     1680

ttgaggatgt gctcagcgcc gatctgaagg aaatcctcga tgaagccttc tccggcgccg     1740

tgaacaagct caatgacgga ttcgtgcagc actccggcaa caatctgtac gtgctccagc     1800

agctgtaccc taatgagacc atcgagagaa tcgccgagaa gtactacaga ctcaccgtga     1860

ggaaggagga tctgaacatg ggagtcaaca ttaaaaagct gagggagctg atcgtgggcc     1920

aatactttcc cgaggtcctc gacaaagaat acgacctctc caagaatgga gacagcgtgg     1980

tgacatacag aagcaagatt tataccgtga tgaattacat tctgctgtat tacctcgagg     2040

accacgactc cagcagagaa agcatggtcg aagctctgag acaaaacaga gagggcgatg     2100

aaggcaagga ggagatctat agacagtttg ccaagaaggt gtggaacggc gtgtccggac     2160

tgtttggcgt gtgtctgaac ctcttcaaga ccgaaaagag aaacaagttt aggagcaaag     2220

tcgccctccc cgatgtgtcc ggcgctgcct atatgctctc ctccgagaac atcgactact     2280

ttgtcaagat gctcttcttt gtgtgtaagt ttctggatgg caaagaaatc aacgagctgc     2340

tgtgcgctct gatcaacaaa tttgataata ttgccgatat tctggatgct gccgctcaat     2400

gtggctcctc cgtctggttc gtggacagct ataggttctt cgagagatct aggaggatta     2460

gcgcccagat tagaatcgtg aagaacatcg cttccaagga ttttaagaaa tccaagaagg     2520

attccgatga gagctacccc gagcagctgt atctggatgc tctggctctg ctcggagacg     2580

tcatctccaa gtacaagcag aatagagatg gcagcgtcgt catcgatgac caaggcaatg     2640

ccgtgctgac agagcaatac aagaggttta gatatgaatt tttcgaggag atcaagaggg     2700

acgaaagcgg cggcatcaag tacaagaagt ccggaaaacc cgagtacaac catcagagaa     2760

ggaattttat tctgaataat gtgctgaaaa gcaaatggtt tttctatgtg gtgaagtaca     2820

ataggcccag cagctgcaga gaactgatga agaataagga aattctgagg ttcgtgctga     2880

gagacatccc cgactcccaa gtgagaagat actttaaggc cgtccaagga gaggaagctt     2940

acgctagcgc cgaagctatg aggacaagac tggtcgacgc tctgtcccaa tttagcgtca     3000

cagcttgtct ggatgaagtg ggcggcatga cagacaagga attcgcctcc cagagggccg     3060

tcgatagcaa agaaaaactg agagccatca tcagactgta tctgacagtc gcctatctga     3120

ttaccaagag catggtgaag gtgaatacaa ggtttagcat tgcctttagc gtgctggaga     3180

gggactacta tctgctcatt gacggcaaga agaaatccag cgactacacc ggagaggata     3240

tgctggctct gaccagaaaa tttgtgggcg aagatgctgg actgtataga gagtggaaag     3300

agaagaacgc tgaagccaag gacaaatatt ttgacaaggc cgaaaggaag aaggtgctga     3360

gacagaacga taagatgatc agaaagatgc acttcacacc ccactccctc aattacgtcc     3420

aaaagaatct cgaaagcgtc cagagcaacg gactggccgc cgtcatcaag gaatatagaa     3480

atgccgtcgc tgccctcaat atcatcaata gactggacga gtacattggc tccgctaggg     3540

ctgatagcta ctactctctg tactgttact gcctccaaat gtatctgagc aagaacttca     3600

gcgtgggcta cctcatcaac gtgcaaaagc agctggagga gcaccacacc tacatgaagg     3660

atctcatgtg gctgctcaac atccccttcg cttacaacct cgccagatac aaaaatctgt     3720

ccaacgaaaa actcttttac gacgaggaag ccgccgccga aaaggctgac aaggctgaga     3780

acgagagagg cgaaggaagc cccaagaaga aaaggaaggt cggcggatct gagcagaaac     3840

tgattagcga agaggatctc taagcggccg cgataatcaa cctctggatt acaaaatttg     3900

tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg gatacgctgc     3960

tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct cctccttgta     4020

taaatcctgg ttagttcttg ccacggcgga actcatcgcc gcctgccttg cccgctgctg     4080

gacaggggct cggctgttgg gcactgacaa ttccgtgggt taacttgttt attgcagctt     4140

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     4200

tgcattctag ttgtggtttg tccaaactca tcaatgtatc tta                       4243


<210>  591
<211>  4587
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  dCas13d AAV vector with ITR

<400>  591
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccggtc gcgtctagta accggctagt tgatccgagc tgagggccta      180

tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga      240

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa      300

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc      360

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc      420

gtagccctgc agtaaggcag ggttctaaga ccagcagcag cagcagcagc agcagcattt      480

tttggtaccg atatcgttta aacaggagtg ggaattggct ccggtgcccg tcagtgggca      540

gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt      600

gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt      660

tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt      720

cgcaacgggt ttgccgccag aacacagaat tccaggtaag tcccgcagcc gtaacgacct      780

tgggggggtg tgagattctc attctaattt tgaagaatat taggtgtaaa agcaagaaat      840

acaatgatcc tgaggtgaca cgcttatgtt ttacttttaa actaggtgaa acgcgtgccg      900

ccaccatgaa gaagaagcac cagagcgccg ccgagaagag gcaagtgaag aagctcaaga      960

atcaagagaa ggcccagaag tacgctagcg agccttcccc cctccagagc gatacagctg     1020

gcgtggaatg ctcccagaaa aagacagtcg tcagccacat tgccagctcc aagacactgg     1080

ccaaggctat gggactcaaa tccacactgg tcatgggcga caagctggtc atcaccagct     1140

ttgctgctag caaggctgtc ggaggcgctg gctacaaaag cgctaacatt gaaaaaatca     1200

cagatctgca aggaagggtc attgaggagc acgaaaggat gtttagcgcc gatgtcggag     1260

agaaaaatat cgaactgagc aagaatgact gccacaccaa cgtcaacaac cccgtggtga     1320

ccaacatcgg aaaggattac atcggactga aatctaggct ggagcaagag tttttcggca     1380

agacattcga gaatgacaat ctgcatgtgc agctggccta caatatcctc gacatcaaga     1440

aaattctggg aacctatgtg aacaatatca tttatatctt ctacaatctg aatagggctg     1500

gcaccggcag agatgagagg atgtatgacg acctcatcgg cacactgtac gcttacaaac     1560

ccatggaggc tcaacagacc tatctgctca aaggcgacaa ggatatgagg aggtttgagg     1620

aggtgaaaca gctgctgcaa aacacctccg cttactatgt gtattacggc acactgttcg     1680

agaaggtgaa ggctaagagc aagaaggaac agagggctaa ggaggccgaa atcgacgctt     1740

gtaccgccca taactacgat gtgctgagac tgctgtccct catgaggcag ctgtgcatgc     1800

actccgtcgc tggaacagcc tttaagctgg ctgagtccgc tctgttcaac attgaggatg     1860

tgctcagcgc cgatctgaag gaaatcctcg atgaagcctt ctccggcgcc gtgaacaagc     1920

tcaatgacgg attcgtgcag cactccggca acaatctgta cgtgctccag cagctgtacc     1980

ctaatgagac catcgagaga atcgccgaga agtactacag actcaccgtg aggaaggagg     2040

atctgaacat gggagtcaac attaaaaagc tgagggagct gatcgtgggc caatactttc     2100

ccgaggtcct cgacaaagaa tacgacctct ccaagaatgg agacagcgtg gtgacataca     2160

gaagcaagat ttataccgtg atgaattaca ttctgctgta ttacctcgag gaccacgact     2220

ccagcagaga aagcatggtc gaagctctga gacaaaacag agagggcgat gaaggcaagg     2280

aggagatcta tagacagttt gccaagaagg tgtggaacgg cgtgtccgga ctgtttggcg     2340

tgtgtctgaa cctcttcaag accgaaaaga gaaacaagtt taggagcaaa gtcgccctcc     2400

ccgatgtgtc cggcgctgcc tatatgctct cctccgagaa catcgactac tttgtcaaga     2460

tgctcttctt tgtgtgtaag tttctggatg gcaaagaaat caacgagctg ctgtgcgctc     2520

tgatcaacaa atttgataat attgccgata ttctggatgc tgccgctcaa tgtggctcct     2580

ccgtctggtt cgtggacagc tataggttct tcgagagatc taggaggatt agcgcccaga     2640

ttagaatcgt gaagaacatc gcttccaagg attttaagaa atccaagaag gattccgatg     2700

agagctaccc cgagcagctg tatctggatg ctctggctct gctcggagac gtcatctcca     2760

agtacaagca gaatagagat ggcagcgtcg tcatcgatga ccaaggcaat gccgtgctga     2820

cagagcaata caagaggttt agatatgaat ttttcgagga gatcaagagg gacgaaagcg     2880

gcggcatcaa gtacaagaag tccggaaaac ccgagtacaa ccatcagaga aggaatttta     2940

ttctgaataa tgtgctgaaa agcaaatggt ttttctatgt ggtgaagtac aataggccca     3000

gcagctgcag agaactgatg aagaataagg aaattctgag gttcgtgctg agagacatcc     3060

ccgactccca agtgagaaga tactttaagg ccgtccaagg agaggaagct tacgctagcg     3120

ccgaagctat gaggacaaga ctggtcgacg ctctgtccca atttagcgtc acagcttgtc     3180

tggatgaagt gggcggcatg acagacaagg aattcgcctc ccagagggcc gtcgatagca     3240

aagaaaaact gagagccatc atcagactgt atctgacagt cgcctatctg attaccaaga     3300

gcatggtgaa ggtgaataca aggtttagca ttgcctttag cgtgctggag agggactact     3360

atctgctcat tgacggcaag aagaaatcca gcgactacac cggagaggat atgctggctc     3420

tgaccagaaa atttgtgggc gaagatgctg gactgtatag agagtggaaa gagaagaacg     3480

ctgaagccaa ggacaaatat tttgacaagg ccgaaaggaa gaaggtgctg agacagaacg     3540

ataagatgat cagaaagatg cacttcacac cccactccct caattacgtc caaaagaatc     3600

tcgaaagcgt ccagagcaac ggactggccg ccgtcatcaa ggaatataga aatgccgtcg     3660

ctgccctcaa tatcatcaat agactggacg agtacattgg ctccgctagg gctgatagct     3720

actactctct gtactgttac tgcctccaaa tgtatctgag caagaacttc agcgtgggct     3780

acctcatcaa cgtgcaaaag cagctggagg agcaccacac ctacatgaag gatctcatgt     3840

ggctgctcaa catccccttc gcttacaacc tcgccagata caaaaatctg tccaacgaaa     3900

aactctttta cgacgaggaa gccgccgccg aaaaggctga caaggctgag aacgagagag     3960

gcgaaggaag ccccaagaag aaaaggaagg tcggcggatc tgagcagaaa ctgattagcg     4020

aagaggatct ctaagcggcc gcgataatca acctctggat tacaaaattt gtgaaagatt     4080

gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc     4140

tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg     4200

gttagttctt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     4260

tcggctgttg ggcactgaca attccgtggg ttaacttgtt tattgcagct tataatggtt     4320

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     4380

gttgtggttt gtccaaactc atcaatgtat cttaacgcgg taaccacgtg cggacccaac     4440

ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     4500

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     4560

gcgagcgagc gcgcagctgc ctgcagg                                         4587


<210>  592
<211>  4243
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  dCas13d AAV vector

<400>  592
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg tagccctgca gtaaggcagg gttctaagac cagcagcagc agcagcagca      300

gcagcatttt ttggtaccga tatcgtttaa acaggagtgg gaattggctc cggtgcccgt      360

cagtgggcag agcgcacatc gcccacagtc cccgagaagt tggggggagg ggtcggcaat      420

tgaaccggtg cctagagaag gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg      480

ctccgccttt ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac      540

gttctttttc gcaacgggtt tgccgccaga acacagaatt ccaggtaagt cccgcagccg      600

taacgacctt gggggggtgt gagattctca ttctaatttt gaagaatatt aggtgtaaaa      660

gcaagaaata caatgatcct gaggtgacac gcttatgttt tacttttaaa ctaggtgaaa      720

cgcgtgccgc caccatgaag aagaagcacc agagcgccgc cgagaagagg caagtgaaga      780

agctcaagaa tcaagagaag gcccagaagt acgctagcga gccttccccc ctccagagcg      840

atacagctgg cgtggaatgc tcccagaaaa agacagtcgt cagccacatt gccagctcca      900

agacactggc caaggctatg ggactcaaat ccacactggt catgggcgac aagctggtca      960

tcaccagctt tgctgctagc aaggctgtcg gaggcgctgg ctacaaaagc gctaacattg     1020

aaaaaatcac agatctgcaa ggaagggtca ttgaggagca cgaaaggatg tttagcgccg     1080

atgtcggaga gaaaaatatc gaactgagca agaatgactg ccacaccaac gtcaacaacc     1140

ccgtggtgac caacatcgga aaggattaca tcggactgaa atctaggctg gagcaagagt     1200

ttttcggcaa gacattcgag aatgacaatc tgcatgtgca gctggcctac aatatcctcg     1260

acatcaagaa aattctggga acctatgtga acaatatcat ttatatcttc tacaatctga     1320

atagggctgg caccggcaga gatgagagga tgtatgacga cctcatcggc acactgtacg     1380

cttacaaacc catggaggct caacagacct atctgctcaa aggcgacaag gatatgagga     1440

ggtttgagga ggtgaaacag ctgctgcaaa acacctccgc ttactatgtg tattacggca     1500

cactgttcga gaaggtgaag gctaagagca agaaggaaca gagggctaag gaggccgaaa     1560

tcgacgcttg taccgcccat aactacgatg tgctgagact gctgtccctc atgaggcagc     1620

tgtgcatgca ctccgtcgct ggaacagcct ttaagctggc tgagtccgct ctgttcaaca     1680

ttgaggatgt gctcagcgcc gatctgaagg aaatcctcga tgaagccttc tccggcgccg     1740

tgaacaagct caatgacgga ttcgtgcagc actccggcaa caatctgtac gtgctccagc     1800

agctgtaccc taatgagacc atcgagagaa tcgccgagaa gtactacaga ctcaccgtga     1860

ggaaggagga tctgaacatg ggagtcaaca ttaaaaagct gagggagctg atcgtgggcc     1920

aatactttcc cgaggtcctc gacaaagaat acgacctctc caagaatgga gacagcgtgg     1980

tgacatacag aagcaagatt tataccgtga tgaattacat tctgctgtat tacctcgagg     2040

accacgactc cagcagagaa agcatggtcg aagctctgag acaaaacaga gagggcgatg     2100

aaggcaagga ggagatctat agacagtttg ccaagaaggt gtggaacggc gtgtccggac     2160

tgtttggcgt gtgtctgaac ctcttcaaga ccgaaaagag aaacaagttt aggagcaaag     2220

tcgccctccc cgatgtgtcc ggcgctgcct atatgctctc ctccgagaac atcgactact     2280

ttgtcaagat gctcttcttt gtgtgtaagt ttctggatgg caaagaaatc aacgagctgc     2340

tgtgcgctct gatcaacaaa tttgataata ttgccgatat tctggatgct gccgctcaat     2400

gtggctcctc cgtctggttc gtggacagct ataggttctt cgagagatct aggaggatta     2460

gcgcccagat tagaatcgtg aagaacatcg cttccaagga ttttaagaaa tccaagaagg     2520

attccgatga gagctacccc gagcagctgt atctggatgc tctggctctg ctcggagacg     2580

tcatctccaa gtacaagcag aatagagatg gcagcgtcgt catcgatgac caaggcaatg     2640

ccgtgctgac agagcaatac aagaggttta gatatgaatt tttcgaggag atcaagaggg     2700

acgaaagcgg cggcatcaag tacaagaagt ccggaaaacc cgagtacaac catcagagaa     2760

ggaattttat tctgaataat gtgctgaaaa gcaaatggtt tttctatgtg gtgaagtaca     2820

ataggcccag cagctgcaga gaactgatga agaataagga aattctgagg ttcgtgctga     2880

gagacatccc cgactcccaa gtgagaagat actttaaggc cgtccaagga gaggaagctt     2940

acgctagcgc cgaagctatg aggacaagac tggtcgacgc tctgtcccaa tttagcgtca     3000

cagcttgtct ggatgaagtg ggcggcatga cagacaagga attcgcctcc cagagggccg     3060

tcgatagcaa agaaaaactg agagccatca tcagactgta tctgacagtc gcctatctga     3120

ttaccaagag catggtgaag gtgaatacaa ggtttagcat tgcctttagc gtgctggaga     3180

gggactacta tctgctcatt gacggcaaga agaaatccag cgactacacc ggagaggata     3240

tgctggctct gaccagaaaa tttgtgggcg aagatgctgg actgtataga gagtggaaag     3300

agaagaacgc tgaagccaag gacaaatatt ttgacaaggc cgaaaggaag aaggtgctga     3360

gacagaacga taagatgatc agaaagatgc acttcacacc ccactccctc aattacgtcc     3420

aaaagaatct cgaaagcgtc cagagcaacg gactggccgc cgtcatcaag gaatatgcaa     3480

atgccgtcgc tcacctcaat atcatcaata gactggacga gtacattggc tccgctaggg     3540

ctgatagcta ctactctctg tactgttact gcctccaaat gtatctgagc aagaacttca     3600

gcgtgggcta cctcatcaac gtgcaaaagc agctggagga gcaccacacc tacatgaagg     3660

atctcatgtg gctgctcaac atccccttcg cttacaacct cgccagatac aaaaatctgt     3720

ccaacgaaaa actcttttac gacgaggaag ccgccgccga aaaggctgac aaggctgaga     3780

acgagagagg cgaaggaagc cccaagaaga aaaggaaggt cggcggatct gagcagaaac     3840

tgattagcga agaggatctc taagcggccg cgataatcaa cctctggatt acaaaatttg     3900

tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg gatacgctgc     3960

tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct cctccttgta     4020

taaatcctgg ttagttcttg ccacggcgga actcatcgcc gcctgccttg cccgctgctg     4080

gacaggggct cggctgttgg gcactgacaa ttccgtgggt taacttgttt attgcagctt     4140

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     4200

tgcattctag ttgtggtttg tccaaactca tcaatgtatc tta                       4243


<210>  593
<211>  4587
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  dCas13d AAV vector with ITR

<400>  593
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccggtc gcgtctagta accggctagt tgatccgagc tgagggccta      180

tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga      240

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa      300

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc      360

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc      420

gtagccctgc agtaaggcag ggttctaaga ccagcagcag cagcagcagc agcagcattt      480

tttggtaccg atatcgttta aacaggagtg ggaattggct ccggtgcccg tcagtgggca      540

gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt      600

gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt      660

tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt      720

cgcaacgggt ttgccgccag aacacagaat tccaggtaag tcccgcagcc gtaacgacct      780

tgggggggtg tgagattctc attctaattt tgaagaatat taggtgtaaa agcaagaaat      840

acaatgatcc tgaggtgaca cgcttatgtt ttacttttaa actaggtgaa acgcgtgccg      900

ccaccatgaa gaagaagcac cagagcgccg ccgagaagag gcaagtgaag aagctcaaga      960

atcaagagaa ggcccagaag tacgctagcg agccttcccc cctccagagc gatacagctg     1020

gcgtggaatg ctcccagaaa aagacagtcg tcagccacat tgccagctcc aagacactgg     1080

ccaaggctat gggactcaaa tccacactgg tcatgggcga caagctggtc atcaccagct     1140

ttgctgctag caaggctgtc ggaggcgctg gctacaaaag cgctaacatt gaaaaaatca     1200

cagatctgca aggaagggtc attgaggagc acgaaaggat gtttagcgcc gatgtcggag     1260

agaaaaatat cgaactgagc aagaatgact gccacaccaa cgtcaacaac cccgtggtga     1320

ccaacatcgg aaaggattac atcggactga aatctaggct ggagcaagag tttttcggca     1380

agacattcga gaatgacaat ctgcatgtgc agctggccta caatatcctc gacatcaaga     1440

aaattctggg aacctatgtg aacaatatca tttatatctt ctacaatctg aatagggctg     1500

gcaccggcag agatgagagg atgtatgacg acctcatcgg cacactgtac gcttacaaac     1560

ccatggaggc tcaacagacc tatctgctca aaggcgacaa ggatatgagg aggtttgagg     1620

aggtgaaaca gctgctgcaa aacacctccg cttactatgt gtattacggc acactgttcg     1680

agaaggtgaa ggctaagagc aagaaggaac agagggctaa ggaggccgaa atcgacgctt     1740

gtaccgccca taactacgat gtgctgagac tgctgtccct catgaggcag ctgtgcatgc     1800

actccgtcgc tggaacagcc tttaagctgg ctgagtccgc tctgttcaac attgaggatg     1860

tgctcagcgc cgatctgaag gaaatcctcg atgaagcctt ctccggcgcc gtgaacaagc     1920

tcaatgacgg attcgtgcag cactccggca acaatctgta cgtgctccag cagctgtacc     1980

ctaatgagac catcgagaga atcgccgaga agtactacag actcaccgtg aggaaggagg     2040

atctgaacat gggagtcaac attaaaaagc tgagggagct gatcgtgggc caatactttc     2100

ccgaggtcct cgacaaagaa tacgacctct ccaagaatgg agacagcgtg gtgacataca     2160

gaagcaagat ttataccgtg atgaattaca ttctgctgta ttacctcgag gaccacgact     2220

ccagcagaga aagcatggtc gaagctctga gacaaaacag agagggcgat gaaggcaagg     2280

aggagatcta tagacagttt gccaagaagg tgtggaacgg cgtgtccgga ctgtttggcg     2340

tgtgtctgaa cctcttcaag accgaaaaga gaaacaagtt taggagcaaa gtcgccctcc     2400

ccgatgtgtc cggcgctgcc tatatgctct cctccgagaa catcgactac tttgtcaaga     2460

tgctcttctt tgtgtgtaag tttctggatg gcaaagaaat caacgagctg ctgtgcgctc     2520

tgatcaacaa atttgataat attgccgata ttctggatgc tgccgctcaa tgtggctcct     2580

ccgtctggtt cgtggacagc tataggttct tcgagagatc taggaggatt agcgcccaga     2640

ttagaatcgt gaagaacatc gcttccaagg attttaagaa atccaagaag gattccgatg     2700

agagctaccc cgagcagctg tatctggatg ctctggctct gctcggagac gtcatctcca     2760

agtacaagca gaatagagat ggcagcgtcg tcatcgatga ccaaggcaat gccgtgctga     2820

cagagcaata caagaggttt agatatgaat ttttcgagga gatcaagagg gacgaaagcg     2880

gcggcatcaa gtacaagaag tccggaaaac ccgagtacaa ccatcagaga aggaatttta     2940

ttctgaataa tgtgctgaaa agcaaatggt ttttctatgt ggtgaagtac aataggccca     3000

gcagctgcag agaactgatg aagaataagg aaattctgag gttcgtgctg agagacatcc     3060

ccgactccca agtgagaaga tactttaagg ccgtccaagg agaggaagct tacgctagcg     3120

ccgaagctat gaggacaaga ctggtcgacg ctctgtccca atttagcgtc acagcttgtc     3180

tggatgaagt gggcggcatg acagacaagg aattcgcctc ccagagggcc gtcgatagca     3240

aagaaaaact gagagccatc atcagactgt atctgacagt cgcctatctg attaccaaga     3300

gcatggtgaa ggtgaataca aggtttagca ttgcctttag cgtgctggag agggactact     3360

atctgctcat tgacggcaag aagaaatcca gcgactacac cggagaggat atgctggctc     3420

tgaccagaaa atttgtgggc gaagatgctg gactgtatag agagtggaaa gagaagaacg     3480

ctgaagccaa ggacaaatat tttgacaagg ccgaaaggaa gaaggtgctg agacagaacg     3540

ataagatgat cagaaagatg cacttcacac cccactccct caattacgtc caaaagaatc     3600

tcgaaagcgt ccagagcaac ggactggccg ccgtcatcaa ggaatatgca aatgccgtcg     3660

ctcacctcaa tatcatcaat agactggacg agtacattgg ctccgctagg gctgatagct     3720

actactctct gtactgttac tgcctccaaa tgtatctgag caagaacttc agcgtgggct     3780

acctcatcaa cgtgcaaaag cagctggagg agcaccacac ctacatgaag gatctcatgt     3840

ggctgctcaa catccccttc gcttacaacc tcgccagata caaaaatctg tccaacgaaa     3900

aactctttta cgacgaggaa gccgccgccg aaaaggctga caaggctgag aacgagagag     3960

gcgaaggaag ccccaagaag aaaaggaagg tcggcggatc tgagcagaaa ctgattagcg     4020

aagaggatct ctaagcggcc gcgataatca acctctggat tacaaaattt gtgaaagatt     4080

gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc     4140

tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg     4200

gttagttctt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     4260

tcggctgttg ggcactgaca attccgtggg ttaacttgtt tattgcagct tataatggtt     4320

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     4380

gttgtggttt gtccaaactc atcaatgtat cttaacgcgg taaccacgtg cggacccaac     4440

ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     4500

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     4560

gcgagcgagc gcgcagctgc ctgcagg                                         4587


<210>  594
<211>  4243
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  dCas13d AAV vector

<400>  594
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg tagccctgca gtaaggcagg gttctaagac cagcagcagc agcagcagca      300

gcagcatttt ttggtaccga tatcgtttaa acaggagtgg gaattggctc cggtgcccgt      360

cagtgggcag agcgcacatc gcccacagtc cccgagaagt tggggggagg ggtcggcaat      420

tgaaccggtg cctagagaag gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg      480

ctccgccttt ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac      540

gttctttttc gcaacgggtt tgccgccaga acacagaatt ccaggtaagt cccgcagccg      600

taacgacctt gggggggtgt gagattctca ttctaatttt gaagaatatt aggtgtaaaa      660

gcaagaaata caatgatcct gaggtgacac gcttatgttt tacttttaaa ctaggtgaaa      720

cgcgtgccgc caccatgaag aagaagcacc agagcgccgc cgagaagagg caagtgaaga      780

agctcaagaa tcaagagaag gcccagaagt acgctagcga gccttccccc ctccagagcg      840

atacagctgg cgtggaatgc tcccagaaaa agacagtcgt cagccacatt gccagctcca      900

agacactggc caaggctatg ggactcaaat ccacactggt catgggcgac aagctggtca      960

tcaccagctt tgctgctagc aaggctgtcg gaggcgctgg ctacaaaagc gctaacattg     1020

aaaaaatcac agatctgcaa ggaagggtca ttgaggagca cgaaaggatg tttagcgccg     1080

atgtcggaga gaaaaatatc gaactgagca agaatgactg ccacaccaac gtcaacaacc     1140

ccgtggtgac caacatcgga aaggattaca tcggactgaa atctaggctg gagcaagagt     1200

ttttcggcaa gacattcgag aatgacaatc tgcatgtgca gctggcctac aatatcctcg     1260

acatcaagaa aattctggga acctatgtga acaatatcat ttatatcttc tacaatctga     1320

atagggctgg caccggcaga gatgagagga tgtatgacga cctcatcggc acactgtacg     1380

cttacaaacc catggaggct caacagacct atctgctcaa aggcgacaag gatatgagga     1440

ggtttgagga ggtgaaacag ctgctgcaaa acacctccgc ttactatgtg tattacggca     1500

cactgttcga gaaggtgaag gctaagagca agaaggaaca gagggctaag gaggccgaaa     1560

tcgacgcttg taccgcccat aactacgatg tgctgagact gctgtccctc atggcgcagc     1620

tgtgcatgca ctccgtcgct ggaacagcct ttaagctggc tgagtccgct ctgttcaaca     1680

ttgaggatgt gctcagcgcc gatctgaagg aaatcctcga tgaagccttc tccggcgccg     1740

tgaacaagct caatgacgga ttcgtgcagc actccggcaa caatctgtac gtgctccagc     1800

agctgtaccc taatgagacc atcgagagaa tcgccgagaa gtactacaga ctcaccgtga     1860

ggaaggagga tctgaacatg ggagtcaaca ttaaaaagct gagggagctg atcgtgggcc     1920

aatactttcc cgaggtcctc gacaaagaat acgacctctc caagaatgga gacagcgtgg     1980

tgacatacag aagcaagatt tataccgtga tgaattacat tctgctgtat tacctcgagg     2040

accacgactc cagcagagaa agcatggtcg aagctctgag acaaaacaga gagggcgatg     2100

aaggcaagga ggagatctat agacagtttg ccaagaaggt gtggaacggc gtgtccggac     2160

tgtttggcgt gtgtctgaac ctcttcaaga ccgaaaagag aaacaagttt aggagcaaag     2220

tcgccctccc cgatgtgtcc ggcgctgcct atatgctctc ctccgagaac atcgactact     2280

ttgtcaagat gctcttcttt gtgtgtaagt ttctggatgg caaagaaatc aacgagctgc     2340

tgtgcgctct gatcaacaaa tttgataata ttgccgatat tctggatgct gccgctcaat     2400

gtggctcctc cgtctggttc gtggacagct ataggttctt cgagagatct aggaggatta     2460

gcgcccagat tagaatcgtg aagaacatcg cttccaagga ttttaagaaa tccaagaagg     2520

attccgatga gagctacccc gagcagctgt atctggatgc tctggctctg ctcggagacg     2580

tcatctccaa gtacaagcag aatagagatg gcagcgtcgt catcgatgac caaggcaatg     2640

ccgtgctgac agagcaatac aagaggttta gatatgaatt tttcgaggag atcaagaggg     2700

acgaaagcgg cggcatcaag tacaagaagt ccggaaaacc cgagtacaac catcagagaa     2760

ggaattttat tctgaataat gtgctgaaaa gcaaatggtt tttctatgtg gtgaagtaca     2820

ataggcccag cagctgcaga gaactgatga agaataagga aattctgagg ttcgtgctga     2880

gagacatccc cgactcccaa gtgagaagat actttaaggc cgtccaagga gaggaagctt     2940

acgctagcgc cgaagctatg aggacaagac tggtcgacgc tctgtcccaa tttagcgtca     3000

cagcttgtct ggatgaagtg ggcggcatga cagacaagga attcgcctcc cagagggccg     3060

tcgatagcaa agaaaaactg agagccatca tcagactgta tctgacagtc gcctatctga     3120

ttaccaagag catggtgaag gtgaatacaa ggtttagcat tgcctttagc gtgctggaga     3180

gggactacta tctgctcatt gacggcaaga agaaatccag cgactacacc ggagaggata     3240

tgctggctct gaccagaaaa tttgtgggcg aagatgctgg actgtataga gagtggaaag     3300

agaagaacgc tgaagccaag gacaaatatt ttgacaaggc cgaaaggaag aaggtgctga     3360

gacagaacga taagatgatc agaaagatgc acttcacacc ccactccctc aattacgtcc     3420

aaaagaatct cgaaagcgtc cagagcaacg gactggccgc cgtcatcaag gaatatagaa     3480

atgccgtcgc tcacctcaat atcatcaata gactggacga gtacattggc tccgctaggg     3540

ctgatagcta ctactctctg tactgttact gcctccaaat gtatctgagc aagaacttca     3600

gcgtgggcta cctcatcaac gtgcaaaagc agctggagga gcaccacacc tacatgaagg     3660

atctcatgtg gctgctcaac atccccttcg cttacaacct cgccagatac aaaaatctgt     3720

ccaacgaaaa actcttttac gacgaggaag ccgccgccga aaaggctgac aaggctgaga     3780

acgagagagg cgaaggaagc cccaagaaga aaaggaaggt cggcggatct gagcagaaac     3840

tgattagcga agaggatctc taagcggccg cgataatcaa cctctggatt acaaaatttg     3900

tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg gatacgctgc     3960

tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct cctccttgta     4020

taaatcctgg ttagttcttg ccacggcgga actcatcgcc gcctgccttg cccgctgctg     4080

gacaggggct cggctgttgg gcactgacaa ttccgtgggt taacttgttt attgcagctt     4140

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     4200

tgcattctag ttgtggtttg tccaaactca tcaatgtatc tta                       4243


<210>  595
<211>  4587
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  dCas13d AAV vector with ITR

<400>  595
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccggtc gcgtctagta accggctagt tgatccgagc tgagggccta      180

tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga      240

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa      300

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc      360

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc      420

gtagccctgc agtaaggcag ggttctaaga ccagcagcag cagcagcagc agcagcattt      480

tttggtaccg atatcgttta aacaggagtg ggaattggct ccggtgcccg tcagtgggca      540

gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt      600

gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt      660

tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt      720

cgcaacgggt ttgccgccag aacacagaat tccaggtaag tcccgcagcc gtaacgacct      780

tgggggggtg tgagattctc attctaattt tgaagaatat taggtgtaaa agcaagaaat      840

acaatgatcc tgaggtgaca cgcttatgtt ttacttttaa actaggtgaa acgcgtgccg      900

ccaccatgaa gaagaagcac cagagcgccg ccgagaagag gcaagtgaag aagctcaaga      960

atcaagagaa ggcccagaag tacgctagcg agccttcccc cctccagagc gatacagctg     1020

gcgtggaatg ctcccagaaa aagacagtcg tcagccacat tgccagctcc aagacactgg     1080

ccaaggctat gggactcaaa tccacactgg tcatgggcga caagctggtc atcaccagct     1140

ttgctgctag caaggctgtc ggaggcgctg gctacaaaag cgctaacatt gaaaaaatca     1200

cagatctgca aggaagggtc attgaggagc acgaaaggat gtttagcgcc gatgtcggag     1260

agaaaaatat cgaactgagc aagaatgact gccacaccaa cgtcaacaac cccgtggtga     1320

ccaacatcgg aaaggattac atcggactga aatctaggct ggagcaagag tttttcggca     1380

agacattcga gaatgacaat ctgcatgtgc agctggccta caatatcctc gacatcaaga     1440

aaattctggg aacctatgtg aacaatatca tttatatctt ctacaatctg aatagggctg     1500

gcaccggcag agatgagagg atgtatgacg acctcatcgg cacactgtac gcttacaaac     1560

ccatggaggc tcaacagacc tatctgctca aaggcgacaa ggatatgagg aggtttgagg     1620

aggtgaaaca gctgctgcaa aacacctccg cttactatgt gtattacggc acactgttcg     1680

agaaggtgaa ggctaagagc aagaaggaac agagggctaa ggaggccgaa atcgacgctt     1740

gtaccgccca taactacgat gtgctgagac tgctgtccct catggcgcag ctgtgcatgc     1800

actccgtcgc tggaacagcc tttaagctgg ctgagtccgc tctgttcaac attgaggatg     1860

tgctcagcgc cgatctgaag gaaatcctcg atgaagcctt ctccggcgcc gtgaacaagc     1920

tcaatgacgg attcgtgcag cactccggca acaatctgta cgtgctccag cagctgtacc     1980

ctaatgagac catcgagaga atcgccgaga agtactacag actcaccgtg aggaaggagg     2040

atctgaacat gggagtcaac attaaaaagc tgagggagct gatcgtgggc caatactttc     2100

ccgaggtcct cgacaaagaa tacgacctct ccaagaatgg agacagcgtg gtgacataca     2160

gaagcaagat ttataccgtg atgaattaca ttctgctgta ttacctcgag gaccacgact     2220

ccagcagaga aagcatggtc gaagctctga gacaaaacag agagggcgat gaaggcaagg     2280

aggagatcta tagacagttt gccaagaagg tgtggaacgg cgtgtccgga ctgtttggcg     2340

tgtgtctgaa cctcttcaag accgaaaaga gaaacaagtt taggagcaaa gtcgccctcc     2400

ccgatgtgtc cggcgctgcc tatatgctct cctccgagaa catcgactac tttgtcaaga     2460

tgctcttctt tgtgtgtaag tttctggatg gcaaagaaat caacgagctg ctgtgcgctc     2520

tgatcaacaa atttgataat attgccgata ttctggatgc tgccgctcaa tgtggctcct     2580

ccgtctggtt cgtggacagc tataggttct tcgagagatc taggaggatt agcgcccaga     2640

ttagaatcgt gaagaacatc gcttccaagg attttaagaa atccaagaag gattccgatg     2700

agagctaccc cgagcagctg tatctggatg ctctggctct gctcggagac gtcatctcca     2760

agtacaagca gaatagagat ggcagcgtcg tcatcgatga ccaaggcaat gccgtgctga     2820

cagagcaata caagaggttt agatatgaat ttttcgagga gatcaagagg gacgaaagcg     2880

gcggcatcaa gtacaagaag tccggaaaac ccgagtacaa ccatcagaga aggaatttta     2940

ttctgaataa tgtgctgaaa agcaaatggt ttttctatgt ggtgaagtac aataggccca     3000

gcagctgcag agaactgatg aagaataagg aaattctgag gttcgtgctg agagacatcc     3060

ccgactccca agtgagaaga tactttaagg ccgtccaagg agaggaagct tacgctagcg     3120

ccgaagctat gaggacaaga ctggtcgacg ctctgtccca atttagcgtc acagcttgtc     3180

tggatgaagt gggcggcatg acagacaagg aattcgcctc ccagagggcc gtcgatagca     3240

aagaaaaact gagagccatc atcagactgt atctgacagt cgcctatctg attaccaaga     3300

gcatggtgaa ggtgaataca aggtttagca ttgcctttag cgtgctggag agggactact     3360

atctgctcat tgacggcaag aagaaatcca gcgactacac cggagaggat atgctggctc     3420

tgaccagaaa atttgtgggc gaagatgctg gactgtatag agagtggaaa gagaagaacg     3480

ctgaagccaa ggacaaatat tttgacaagg ccgaaaggaa gaaggtgctg agacagaacg     3540

ataagatgat cagaaagatg cacttcacac cccactccct caattacgtc caaaagaatc     3600

tcgaaagcgt ccagagcaac ggactggccg ccgtcatcaa ggaatataga aatgccgtcg     3660

ctcacctcaa tatcatcaat agactggacg agtacattgg ctccgctagg gctgatagct     3720

actactctct gtactgttac tgcctccaaa tgtatctgag caagaacttc agcgtgggct     3780

acctcatcaa cgtgcaaaag cagctggagg agcaccacac ctacatgaag gatctcatgt     3840

ggctgctcaa catccccttc gcttacaacc tcgccagata caaaaatctg tccaacgaaa     3900

aactctttta cgacgaggaa gccgccgccg aaaaggctga caaggctgag aacgagagag     3960

gcgaaggaag ccccaagaag aaaaggaagg tcggcggatc tgagcagaaa ctgattagcg     4020

aagaggatct ctaagcggcc gcgataatca acctctggat tacaaaattt gtgaaagatt     4080

gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc     4140

tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg     4200

gttagttctt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     4260

tcggctgttg ggcactgaca attccgtggg ttaacttgtt tattgcagct tataatggtt     4320

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     4380

gttgtggttt gtccaaactc atcaatgtat cttaacgcgg taaccacgtg cggacccaac     4440

ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     4500

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     4560

gcgagcgagc gcgcagctgc ctgcagg                                         4587


<210>  596
<211>  4243
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  dCas13d AAV vector

<400>  596
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg tagccctgca gtaaggcagg gttctaagac cagcagcagc agcagcagca      300

gcagcatttt ttggtaccga tatcgtttaa acaggagtgg gaattggctc cggtgcccgt      360

cagtgggcag agcgcacatc gcccacagtc cccgagaagt tggggggagg ggtcggcaat      420

tgaaccggtg cctagagaag gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg      480

ctccgccttt ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac      540

gttctttttc gcaacgggtt tgccgccaga acacagaatt ccaggtaagt cccgcagccg      600

taacgacctt gggggggtgt gagattctca ttctaatttt gaagaatatt aggtgtaaaa      660

gcaagaaata caatgatcct gaggtgacac gcttatgttt tacttttaaa ctaggtgaaa      720

cgcgtgccgc caccatgaag aagaagcacc agagcgccgc cgagaagagg caagtgaaga      780

agctcaagaa tcaagagaag gcccagaagt acgctagcga gccttccccc ctccagagcg      840

atacagctgg cgtggaatgc tcccagaaaa agacagtcgt cagccacatt gccagctcca      900

agacactggc caaggctatg ggactcaaat ccacactggt catgggcgac aagctggtca      960

tcaccagctt tgctgctagc aaggctgtcg gaggcgctgg ctacaaaagc gctaacattg     1020

aaaaaatcac agatctgcaa ggaagggtca ttgaggagca cgaaaggatg tttagcgccg     1080

atgtcggaga gaaaaatatc gaactgagca agaatgactg ccacaccaac gtcaacaacc     1140

ccgtggtgac caacatcgga aaggattaca tcggactgaa atctaggctg gagcaagagt     1200

ttttcggcaa gacattcgag aatgacaatc tgcatgtgca gctggcctac aatatcctcg     1260

acatcaagaa aattctggga acctatgtga acaatatcat ttatatcttc tacaatctga     1320

atagggctgg caccggcaga gatgagagga tgtatgacga cctcatcggc acactgtacg     1380

cttacaaacc catggaggct caacagacct atctgctcaa aggcgacaag gatatgagga     1440

ggtttgagga ggtgaaacag ctgctgcaaa acacctccgc ttactatgtg tattacggca     1500

cactgttcga gaaggtgaag gctaagagca agaaggaaca gagggctaag gaggccgaaa     1560

tcgacgcttg taccgcccat aactacgatg tgctgagact gctgtccctc atgaggcagc     1620

tgtgcatggc ctccgtcgct ggaacagcct ttaagctggc tgagtccgct ctgttcaaca     1680

ttgaggatgt gctcagcgcc gatctgaagg aaatcctcga tgaagccttc tccggcgccg     1740

tgaacaagct caatgacgga ttcgtgcagc actccggcaa caatctgtac gtgctccagc     1800

agctgtaccc taatgagacc atcgagagaa tcgccgagaa gtactacaga ctcaccgtga     1860

ggaaggagga tctgaacatg ggagtcaaca ttaaaaagct gagggagctg atcgtgggcc     1920

aatactttcc cgaggtcctc gacaaagaat acgacctctc caagaatgga gacagcgtgg     1980

tgacatacag aagcaagatt tataccgtga tgaattacat tctgctgtat tacctcgagg     2040

accacgactc cagcagagaa agcatggtcg aagctctgag acaaaacaga gagggcgatg     2100

aaggcaagga ggagatctat agacagtttg ccaagaaggt gtggaacggc gtgtccggac     2160

tgtttggcgt gtgtctgaac ctcttcaaga ccgaaaagag aaacaagttt aggagcaaag     2220

tcgccctccc cgatgtgtcc ggcgctgcct atatgctctc ctccgagaac atcgactact     2280

ttgtcaagat gctcttcttt gtgtgtaagt ttctggatgg caaagaaatc aacgagctgc     2340

tgtgcgctct gatcaacaaa tttgataata ttgccgatat tctggatgct gccgctcaat     2400

gtggctcctc cgtctggttc gtggacagct ataggttctt cgagagatct aggaggatta     2460

gcgcccagat tagaatcgtg aagaacatcg cttccaagga ttttaagaaa tccaagaagg     2520

attccgatga gagctacccc gagcagctgt atctggatgc tctggctctg ctcggagacg     2580

tcatctccaa gtacaagcag aatagagatg gcagcgtcgt catcgatgac caaggcaatg     2640

ccgtgctgac agagcaatac aagaggttta gatatgaatt tttcgaggag atcaagaggg     2700

acgaaagcgg cggcatcaag tacaagaagt ccggaaaacc cgagtacaac catcagagaa     2760

ggaattttat tctgaataat gtgctgaaaa gcaaatggtt tttctatgtg gtgaagtaca     2820

ataggcccag cagctgcaga gaactgatga agaataagga aattctgagg ttcgtgctga     2880

gagacatccc cgactcccaa gtgagaagat actttaaggc cgtccaagga gaggaagctt     2940

acgctagcgc cgaagctatg aggacaagac tggtcgacgc tctgtcccaa tttagcgtca     3000

cagcttgtct ggatgaagtg ggcggcatga cagacaagga attcgcctcc cagagggccg     3060

tcgatagcaa agaaaaactg agagccatca tcagactgta tctgacagtc gcctatctga     3120

ttaccaagag catggtgaag gtgaatacaa ggtttagcat tgcctttagc gtgctggaga     3180

gggactacta tctgctcatt gacggcaaga agaaatccag cgactacacc ggagaggata     3240

tgctggctct gaccagaaaa tttgtgggcg aagatgctgg actgtataga gagtggaaag     3300

agaagaacgc tgaagccaag gacaaatatt ttgacaaggc cgaaaggaag aaggtgctga     3360

gacagaacga taagatgatc agaaagatgc acttcacacc ccactccctc aattacgtcc     3420

aaaagaatct cgaaagcgtc cagagcaacg gactggccgc cgtcatcaag gaatatagaa     3480

atgccgtcgc tcacctcaat atcatcaata gactggacga gtacattggc tccgctaggg     3540

ctgatagcta ctactctctg tactgttact gcctccaaat gtatctgagc aagaacttca     3600

gcgtgggcta cctcatcaac gtgcaaaagc agctggagga gcaccacacc tacatgaagg     3660

atctcatgtg gctgctcaac atccccttcg cttacaacct cgccagatac aaaaatctgt     3720

ccaacgaaaa actcttttac gacgaggaag ccgccgccga aaaggctgac aaggctgaga     3780

acgagagagg cgaaggaagc cccaagaaga aaaggaaggt cggcggatct gagcagaaac     3840

tgattagcga agaggatctc taagcggccg cgataatcaa cctctggatt acaaaatttg     3900

tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg gatacgctgc     3960

tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct cctccttgta     4020

taaatcctgg ttagttcttg ccacggcgga actcatcgcc gcctgccttg cccgctgctg     4080

gacaggggct cggctgttgg gcactgacaa ttccgtgggt taacttgttt attgcagctt     4140

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     4200

tgcattctag ttgtggtttg tccaaactca tcaatgtatc tta                       4243


<210>  597
<211>  4587
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  dCas13d AAV vector with ITR

<400>  597
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccggtc gcgtctagta accggctagt tgatccgagc tgagggccta      180

tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga      240

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa      300

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc      360

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc      420

gtagccctgc agtaaggcag ggttctaaga ccagcagcag cagcagcagc agcagcattt      480

tttggtaccg atatcgttta aacaggagtg ggaattggct ccggtgcccg tcagtgggca      540

gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt      600

gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt      660

tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt      720

cgcaacgggt ttgccgccag aacacagaat tccaggtaag tcccgcagcc gtaacgacct      780

tgggggggtg tgagattctc attctaattt tgaagaatat taggtgtaaa agcaagaaat      840

acaatgatcc tgaggtgaca cgcttatgtt ttacttttaa actaggtgaa acgcgtgccg      900

ccaccatgaa gaagaagcac cagagcgccg ccgagaagag gcaagtgaag aagctcaaga      960

atcaagagaa ggcccagaag tacgctagcg agccttcccc cctccagagc gatacagctg     1020

gcgtggaatg ctcccagaaa aagacagtcg tcagccacat tgccagctcc aagacactgg     1080

ccaaggctat gggactcaaa tccacactgg tcatgggcga caagctggtc atcaccagct     1140

ttgctgctag caaggctgtc ggaggcgctg gctacaaaag cgctaacatt gaaaaaatca     1200

cagatctgca aggaagggtc attgaggagc acgaaaggat gtttagcgcc gatgtcggag     1260

agaaaaatat cgaactgagc aagaatgact gccacaccaa cgtcaacaac cccgtggtga     1320

ccaacatcgg aaaggattac atcggactga aatctaggct ggagcaagag tttttcggca     1380

agacattcga gaatgacaat ctgcatgtgc agctggccta caatatcctc gacatcaaga     1440

aaattctggg aacctatgtg aacaatatca tttatatctt ctacaatctg aatagggctg     1500

gcaccggcag agatgagagg atgtatgacg acctcatcgg cacactgtac gcttacaaac     1560

ccatggaggc tcaacagacc tatctgctca aaggcgacaa ggatatgagg aggtttgagg     1620

aggtgaaaca gctgctgcaa aacacctccg cttactatgt gtattacggc acactgttcg     1680

agaaggtgaa ggctaagagc aagaaggaac agagggctaa ggaggccgaa atcgacgctt     1740

gtaccgccca taactacgat gtgctgagac tgctgtccct catgaggcag ctgtgcatgg     1800

cctccgtcgc tggaacagcc tttaagctgg ctgagtccgc tctgttcaac attgaggatg     1860

tgctcagcgc cgatctgaag gaaatcctcg atgaagcctt ctccggcgcc gtgaacaagc     1920

tcaatgacgg attcgtgcag cactccggca acaatctgta cgtgctccag cagctgtacc     1980

ctaatgagac catcgagaga atcgccgaga agtactacag actcaccgtg aggaaggagg     2040

atctgaacat gggagtcaac attaaaaagc tgagggagct gatcgtgggc caatactttc     2100

ccgaggtcct cgacaaagaa tacgacctct ccaagaatgg agacagcgtg gtgacataca     2160

gaagcaagat ttataccgtg atgaattaca ttctgctgta ttacctcgag gaccacgact     2220

ccagcagaga aagcatggtc gaagctctga gacaaaacag agagggcgat gaaggcaagg     2280

aggagatcta tagacagttt gccaagaagg tgtggaacgg cgtgtccgga ctgtttggcg     2340

tgtgtctgaa cctcttcaag accgaaaaga gaaacaagtt taggagcaaa gtcgccctcc     2400

ccgatgtgtc cggcgctgcc tatatgctct cctccgagaa catcgactac tttgtcaaga     2460

tgctcttctt tgtgtgtaag tttctggatg gcaaagaaat caacgagctg ctgtgcgctc     2520

tgatcaacaa atttgataat attgccgata ttctggatgc tgccgctcaa tgtggctcct     2580

ccgtctggtt cgtggacagc tataggttct tcgagagatc taggaggatt agcgcccaga     2640

ttagaatcgt gaagaacatc gcttccaagg attttaagaa atccaagaag gattccgatg     2700

agagctaccc cgagcagctg tatctggatg ctctggctct gctcggagac gtcatctcca     2760

agtacaagca gaatagagat ggcagcgtcg tcatcgatga ccaaggcaat gccgtgctga     2820

cagagcaata caagaggttt agatatgaat ttttcgagga gatcaagagg gacgaaagcg     2880

gcggcatcaa gtacaagaag tccggaaaac ccgagtacaa ccatcagaga aggaatttta     2940

ttctgaataa tgtgctgaaa agcaaatggt ttttctatgt ggtgaagtac aataggccca     3000

gcagctgcag agaactgatg aagaataagg aaattctgag gttcgtgctg agagacatcc     3060

ccgactccca agtgagaaga tactttaagg ccgtccaagg agaggaagct tacgctagcg     3120

ccgaagctat gaggacaaga ctggtcgacg ctctgtccca atttagcgtc acagcttgtc     3180

tggatgaagt gggcggcatg acagacaagg aattcgcctc ccagagggcc gtcgatagca     3240

aagaaaaact gagagccatc atcagactgt atctgacagt cgcctatctg attaccaaga     3300

gcatggtgaa ggtgaataca aggtttagca ttgcctttag cgtgctggag agggactact     3360

atctgctcat tgacggcaag aagaaatcca gcgactacac cggagaggat atgctggctc     3420

tgaccagaaa atttgtgggc gaagatgctg gactgtatag agagtggaaa gagaagaacg     3480

ctgaagccaa ggacaaatat tttgacaagg ccgaaaggaa gaaggtgctg agacagaacg     3540

ataagatgat cagaaagatg cacttcacac cccactccct caattacgtc caaaagaatc     3600

tcgaaagcgt ccagagcaac ggactggccg ccgtcatcaa ggaatataga aatgccgtcg     3660

ctcacctcaa tatcatcaat agactggacg agtacattgg ctccgctagg gctgatagct     3720

actactctct gtactgttac tgcctccaaa tgtatctgag caagaacttc agcgtgggct     3780

acctcatcaa cgtgcaaaag cagctggagg agcaccacac ctacatgaag gatctcatgt     3840

ggctgctcaa catccccttc gcttacaacc tcgccagata caaaaatctg tccaacgaaa     3900

aactctttta cgacgaggaa gccgccgccg aaaaggctga caaggctgag aacgagagag     3960

gcgaaggaag ccccaagaag aaaaggaagg tcggcggatc tgagcagaaa ctgattagcg     4020

aagaggatct ctaagcggcc gcgataatca acctctggat tacaaaattt gtgaaagatt     4080

gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc     4140

tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg     4200

gttagttctt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     4260

tcggctgttg ggcactgaca attccgtggg ttaacttgtt tattgcagct tataatggtt     4320

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     4380

gttgtggttt gtccaaactc atcaatgtat cttaacgcgg taaccacgtg cggacccaac     4440

ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     4500

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     4560

gcgagcgagc gcgcagctgc ctgcagg                                         4587


<210>  598
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PIN nuclease

<400>  598

Gln Met Glu Leu Glu Ile Arg Pro Leu Phe Leu Val Pro Asp Thr Asn 
1               5                   10                  15      


Gly Phe Ile Asp His Leu Ala Ser Leu Ala Arg Leu Leu Glu Ser Arg 
            20                  25                  30          


Lys Tyr Ile Leu Val Val Pro Leu Ile Val Ile Asn Glu Leu Asp Gly 
        35                  40                  45              


Leu Ala Lys Gly Gln Glu Thr Asp His Arg Ala Gly Gly Tyr Ala Arg 
    50                  55                  60                  


Val Val Gln Glu Lys Ala Arg Lys Ser Ile Glu Phe Leu Glu Gln Arg 
65                  70                  75                  80  


Phe Glu Ser Arg Asp Ser Cys Leu Arg Ala Leu Thr Ser Arg Gly Asn 
                85                  90                  95      


Glu Leu Glu Ser Ile Ala Phe Arg Ser Glu Asp Ile Thr Gly Gln Leu 
            100                 105                 110         


Gly Asn Asn Asp Asp Leu Ile Leu Ser Cys Cys Leu His Tyr Cys Lys 
        115                 120                 125             


Asp Lys Ala Lys Asp Phe Met Pro Ala Ser Lys Glu Glu Pro Ile Arg 
    130                 135                 140                 


Leu Leu Arg Glu Val Val Leu Leu Thr Asp Asp Arg Asn Leu Arg Val 
145                 150                 155                 160 


Lys Ala Leu Thr Arg Asn Val Pro Val Arg Asp Ile Pro Ala Phe Leu 
                165                 170                 175     


Thr Trp Ala Gln Val Gly 
            180         


<210>  599
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  ITR

<400>  599
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  600
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  ITR

<400>  600
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  601
<211>  3057
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  cas13d seq212

<400>  601
aagaagaagc accagagcgc cgccgagaag aggcaagtga agaagctcaa gaatcaagag       60

aaggcccaga agtacgctag cgagccttcc cccctccaga gcgatacagc tggcgtggaa      120

tgctcccaga aaaagacagt cgtcagccac attgccagct ccaagacact ggccaaggct      180

atgggactca aatccacact ggtcatgggc gacaagctgg tcatcaccag ctttgctgct      240

agcaaggctg tcggaggcgc tggctacaaa agcgctaaca ttgaaaaaat cacagatctg      300

caaggaaggg tcattgagga gcacgaaagg atgtttagcg ccgatgtcgg agagaaaaat      360

atcgaactga gcaagaatga ctgccacacc aacgtcaaca accccgtggt gaccaacatc      420

ggaaaggatt acatcggact gaaatctagg ctggagcaag agtttttcgg caagacattc      480

gagaatgaca atctgcatgt gcagctggcc tacaatatcc tcgacatcaa gaaaattctg      540

ggaacctatg tgaacaatat catttatatc ttctacaatc tgaatagggc tggcaccggc      600

agagatgaga ggatgtatga cgacctcatc ggcacactgt acgcttacaa acccatggag      660

gctcaacaga cctatctgct caaaggcgac aaggatatga ggaggtttga ggaggtgaaa      720

cagctgctgc aaaacacctc cgcttactat gtgtattacg gcacactgtt cgagaaggtg      780

aaggctaaga gcaagaagga acagagggct aaggaggccg aaatcgacgc ttgtaccgcc      840

cataactacg atgtgctgag actgctgtcc ctcatgaggc agctgtgcat gcactccgtc      900

gctggaacag cctttaagct ggctgagtcc gctctgttca acattgagga tgtgctcagc      960

gccgatctga aggaaatcct cgatgaagcc ttctccggcg ccgtgaacaa gctcaatgac     1020

ggattcgtgc agcactccgg caacaatctg tacgtgctcc agcagctgta ccctaatgag     1080

accatcgaga gaatcgccga gaagtactac agactcaccg tgaggaagga ggatctgaac     1140

atgggagtca acattaaaaa gctgagggag ctgatcgtgg gccaatactt tcccgaggtc     1200

ctcgacaaag aatacgacct ctccaagaat ggagacagcg tggtgacata cagaagcaag     1260

atttataccg tgatgaatta cattctgctg tattacctcg aggaccacga ctccagcaga     1320

gaaagcatgg tcgaagctct gagacaaaac agagagggcg atgaaggcaa ggaggagatc     1380

tatagacagt ttgccaagaa ggtgtggaac ggcgtgtccg gactgtttgg cgtgtgtctg     1440

aacctcttca agaccgaaaa gagaaacaag tttaggagca aagtcgccct ccccgatgtg     1500

tccggcgctg cctatatgct ctcctccgag aacatcgact actttgtcaa gatgctcttc     1560

tttgtgtgta agtttctgga tggcaaagaa atcaacgagc tgctgtgcgc tctgatcaac     1620

aaatttgata atattgccga tattctggat gctgccgctc aatgtggctc ctccgtctgg     1680

ttcgtggaca gctataggtt cttcgagaga tctaggagga ttagcgccca gattagaatc     1740

gtgaagaaca tcgcttccaa ggattttaag aaatccaaga aggattccga tgagagctac     1800

cccgagcagc tgtatctgga tgctctggct ctgctcggag acgtcatctc caagtacaag     1860

cagaatagag atggcagcgt cgtcatcgat gaccaaggca atgccgtgct gacagagcaa     1920

tacaagaggt ttagatatga atttttcgag gagatcaaga gggacgaaag cggcggcatc     1980

aagtacaaga agtccggaaa acccgagtac aaccatcaga gaaggaattt tattctgaat     2040

aatgtgctga aaagcaaatg gtttttctat gtggtgaagt acaataggcc cagcagctgc     2100

agagaactga tgaagaataa ggaaattctg aggttcgtgc tgagagacat ccccgactcc     2160

caagtgagaa gatactttaa ggccgtccaa ggagaggaag cttacgctag cgccgaagct     2220

atgaggacaa gactggtcga cgctctgtcc caatttagcg tcacagcttg tctggatgaa     2280

gtgggcggca tgacagacaa ggaattcgcc tcccagaggg ccgtcgatag caaagaaaaa     2340

ctgagagcca tcatcagact gtatctgaca gtcgcctatc tgattaccaa gagcatggtg     2400

aaggtgaata caaggtttag cattgccttt agcgtgctgg agagggacta ctatctgctc     2460

attgacggca agaagaaatc cagcgactac accggagagg atatgctggc tctgaccaga     2520

aaatttgtgg gcgaagatgc tggactgtat agagagtgga aagagaagaa cgctgaagcc     2580

aaggacaaat attttgacaa ggccgaaagg aagaaggtgc tgagacagaa cgataagatg     2640

atcagaaaga tgcacttcac accccactcc ctcaattacg tccaaaagaa tctcgaaagc     2700

gtccagagca acggactggc cgccgtcatc aaggaatata gaaatgccgt cgctcacctc     2760

aatatcatca atagactgga cgagtacatt ggctccgcta gggctgatag ctactactct     2820

ctgtactgtt actgcctcca aatgtatctg agcaagaact tcagcgtggg ctacctcatc     2880

aacgtgcaaa agcagctgga ggagcaccac acctacatga aggatctcat gtggctgctc     2940

aacatcccct tcgcttacaa cctcgccaga tacaaaaatc tgtccaacga aaaactcttt     3000

tacgacgagg aagccgccgc cgaaaaggct gacaaggctg agaacgagag aggcgaa        3057


<210>  602
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  myc tag

<400>  602
gagcagaaac tgattagcga agaggatctc                                        30


<210>  603
<211>  247
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  WPRE

<400>  603
gataatcaac ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt       60

gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc      120

cgtatggctt tcattttctc ctccttgtat aaatcctggt tagttcttgc cacggcggaa      180

ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat      240

tccgtgg                                                                247


<210>  604
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Rb-NLS

<400>  604
gaccgtgtgc tcaaaagaag tgctgaagga agcaaccctc ctaaaccact gaaaaaacta       60

cgc                                                                     63


<210>  605
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  605
gtggatactg ccaatggcag c                                                 21


<210>  606
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  E17 endonuclease

<400>  606
ggtggtggca cccctaaggc tcccaacctg gagcctccac tcccagaaga ggaaaaggag       60

ggcagcgacc tgagaccagt ggtcatcgat gggagcaacg tggccatgag ccatgggaac      120

aaggaggtct tctcctgccg gggcatcctg ctggcagtga actggtttct ggagcggggc      180

cacacagaca tcacagtgtt tgtgccatcc tggaggaagg agcagcctcg gcccgacgtg      240

cccatcacag accagcacat cctgcgggaa ctggagaaga agaagatcct ggtgttcaca      300

ccatcacgac gcgtgggtgg caagcgggtg gtgtgctatg acgacagatt cattgtgaag      360

ctggcctacg agtctgacgg gatcgtggtt tccaacgaca cataccgtga cctccaaggc      420

gagcggcagg agtggaagcg cttcatcgag gagcggctgc tcatgtactc cttcgtcaat      480

gacaagttta tgccccctga tgacccactg ggccggcacg ggcccagcct ggacaacttc      540

ctgcgtaaga agccactcac tttggag                                          567


<210>  607
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  WPRE

<400>  607
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc                  589


<210>  608
<211>  1060
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  human desmin full

<400>  608
taccccctgc cccccacagc tcctctcctg tgccttgttt cccagccatg cgttctcctc       60

tataaatacc cgctctggta tttggggttg gcagctgttg ctgccaggga gatggttggg      120

ttgacatgcg gctcctgaca aaacacaaac ccctggtgtg tgtgggcgtg ggtggtgtga      180

gtagggggat gaatcaggga gggggcaggg gacccagggg gcaggagcca cacaaagtct      240

gtgcgggggt gggagcgcac atagcaattg gaaactgaaa gcttatcaga ccctttctgg      300

aaatcagccc actgtttata aacttgaggc cccaccctcg acagtaccgg ggaggaagag      360

ggcctgcact agtccagagg gaaactgagg ctcagggcca gctcgcccat agacatacat      420

ggcaggcagg ctttggccag gatccctccg cctgccaggc gtctccctgc cctcccttcc      480

tgcctagaga cccccaccct caagcctggc tggtctttgc ctgagaccca aacctcttcg      540

acttcaagag aatatttagg aacaaggtgg tttagggcct ttcctgggaa caggccttga      600

ccctttaaga aatgacccaa agtctctcct tgaccaaaaa ggggaccctc aaactaaagg      660

gaagcctctc ttctgctgtc tcccctgacc ccactccccc ccaccccagg acgaggagat      720

aaccagggct gaaagaggcc cgcctggggg ctgcagacat gcttgctgcc tgccctggcg      780

aaggattggc aggcttgccc gtcacaggac ccccgctggc tgactcaggg gcgcaggcct      840

tttgcggggg agctggcctc cccgccccca cggccacggg ccgccctttc ctggcaggac      900

agcgggatct tgcagctgtc aggggagggg aggcgggggc tgatgtcagg agggatacaa      960

atagtgccga cggctggggg ccctgtctcc cctcgccgca tccactctcc ggccggccgc     1020

ctgcccgccg cctcctccgt gcgcccgcca gcctcgcccg                           1060


<210>  609
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  EFS/UBB promoter

<400>  609
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa       60

ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac agaattccag gtaagtcccg cagccgtaac      240

gaccttgggg gggtgtgaga ttctcattct aattttgaag aatattaggt gtaaaagcaa      300

gaaatacaat gatcctgagg tgacacgctt atgttttact tttaaactag gt              352


<210>  610
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Myc Tag

<400>  610

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  611
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  611
ggcggaagt                                                                9


<210>  612
<211>  3057
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  dead Cas13d

<400>  612
aagaagaagc accagagcgc cgccgagaag aggcaagtga agaagctcaa gaatcaagag       60

aaggcccaga agtacgctag cgagccttcc cccctccaga gcgatacagc tggcgtggaa      120

tgctcccaga aaaagacagt cgtcagccac attgccagct ccaagacact ggccaaggct      180

atgggactca aatccacact ggtcatgggc gacaagctgg tcatcaccag ctttgctgct      240

agcaaggctg tcggaggcgc tggctacaaa agcgctaaca ttgaaaaaat cacagatctg      300

caaggaaggg tcattgagga gcacgaaagg atgtttagcg ccgatgtcgg agagaaaaat      360

atcgaactga gcaagaatga ctgccacacc aacgtcaaca accccgtggt gaccaacatc      420

ggaaaggatt acatcggact gaaatctagg ctggagcaag agtttttcgg caagacattc      480

gagaatgaca atctgcatgt gcagctggcc tacaatatcc tcgacatcaa gaaaattctg      540

ggaacctatg tgaacaatat catttatatc ttctacaatc tgaatagggc tggcaccggc      600

agagatgaga ggatgtatga cgacctcatc ggcacactgt acgcttacaa acccatggag      660

gctcaacaga cctatctgct caaaggcgac aaggatatga ggaggtttga ggaggtgaaa      720

cagctgctgc aaaacacctc cgcttactat gtgtattacg gcacactgtt cgagaaggtg      780

aaggctaaga gcaagaagga acagagggct aaggaggccg aaatcgacgc ttgtaccgcc      840

cataactacg atgtgctgag actgctgtcc ctcatggcgc agctgtgcat ggcctccgtc      900

gctggaacag cctttaagct ggctgagtcc gctctgttca acattgagga tgtgctcagc      960

gccgatctga aggaaatcct cgatgaagcc ttctccggcg ccgtgaacaa gctcaatgac     1020

ggattcgtgc agcactccgg caacaatctg tacgtgctcc agcagctgta ccctaatgag     1080

accatcgaga gaatcgccga gaagtactac agactcaccg tgaggaagga ggatctgaac     1140

atgggagtca acattaaaaa gctgagggag ctgatcgtgg gccaatactt tcccgaggtc     1200

ctcgacaaag aatacgacct ctccaagaat ggagacagcg tggtgacata cagaagcaag     1260

atttataccg tgatgaatta cattctgctg tattacctcg aggaccacga ctccagcaga     1320

gaaagcatgg tcgaagctct gagacaaaac agagagggcg atgaaggcaa ggaggagatc     1380

tatagacagt ttgccaagaa ggtgtggaac ggcgtgtccg gactgtttgg cgtgtgtctg     1440

aacctcttca agaccgaaaa gagaaacaag tttaggagca aagtcgccct ccccgatgtg     1500

tccggcgctg cctatatgct ctcctccgag aacatcgact actttgtcaa gatgctcttc     1560

tttgtgtgta agtttctgga tggcaaagaa atcaacgagc tgctgtgcgc tctgatcaac     1620

aaatttgata atattgccga tattctggat gctgccgctc aatgtggctc ctccgtctgg     1680

ttcgtggaca gctataggtt cttcgagaga tctaggagga ttagcgccca gattagaatc     1740

gtgaagaaca tcgcttccaa ggattttaag aaatccaaga aggattccga tgagagctac     1800

cccgagcagc tgtatctgga tgctctggct ctgctcggag acgtcatctc caagtacaag     1860

cagaatagag atggcagcgt cgtcatcgat gaccaaggca atgccgtgct gacagagcaa     1920

tacaagaggt ttagatatga atttttcgag gagatcaaga gggacgaaag cggcggcatc     1980

aagtacaaga agtccggaaa acccgagtac aaccatcaga gaaggaattt tattctgaat     2040

aatgtgctga aaagcaaatg gtttttctat gtggtgaagt acaataggcc cagcagctgc     2100

agagaactga tgaagaataa ggaaattctg aggttcgtgc tgagagacat ccccgactcc     2160

caagtgagaa gatactttaa ggccgtccaa ggagaggaag cttacgctag cgccgaagct     2220

atgaggacaa gactggtcga cgctctgtcc caatttagcg tcacagcttg tctggatgaa     2280

gtgggcggca tgacagacaa ggaattcgcc tcccagaggg ccgtcgatag caaagaaaaa     2340

ctgagagcca tcatcagact gtatctgaca gtcgcctatc tgattaccaa gagcatggtg     2400

aaggtgaata caaggtttag cattgccttt agcgtgctgg agagggacta ctatctgctc     2460

attgacggca agaagaaatc cagcgactac accggagagg atatgctggc tctgaccaga     2520

aaatttgtgg gcgaagatgc tggactgtat agagagtgga aagagaagaa cgctgaagcc     2580

aaggacaaat attttgacaa ggccgaaagg aagaaggtgc tgagacagaa cgataagatg     2640

atcagaaaga tgcacttcac accccactcc ctcaattacg tccaaaagaa tctcgaaagc     2700

gtccagagca acggactggc cgccgtcatc aaggaatatg caaatgccgt cgctgccctc     2760

aatatcatca atagactgga cgagtacatt ggctccgcta gggctgatag ctactactct     2820

ctgtactgtt actgcctcca aatgtatctg agcaagaact tcagcgtggg ctacctcatc     2880

aacgtgcaaa agcagctgga ggagcaccac acctacatga aggatctcat gtggctgctc     2940

aacatcccct tcgcttacaa cctcgccaga tacaaaaatc tgtccaacga aaaactcttt     3000

tacgacgagg aagccgccgc cgaaaaggct gacaaggctg agaacgagag aggcgaa        3057


<210>  613
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  613
ggcggatct                                                                9


<210>  614
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  cas13d seq212 dr

<400>  614
tagccctgca gtaaggcagg gttctaagac                                        30


<210>  615
<211>  3057
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  dCas13d seq212 H919A

<400>  615
aagaagaagc accagagcgc cgccgagaag aggcaagtga agaagctcaa gaatcaagag       60

aaggcccaga agtacgctag cgagccttcc cccctccaga gcgatacagc tggcgtggaa      120

tgctcccaga aaaagacagt cgtcagccac attgccagct ccaagacact ggccaaggct      180

atgggactca aatccacact ggtcatgggc gacaagctgg tcatcaccag ctttgctgct      240

agcaaggctg tcggaggcgc tggctacaaa agcgctaaca ttgaaaaaat cacagatctg      300

caaggaaggg tcattgagga gcacgaaagg atgtttagcg ccgatgtcgg agagaaaaat      360

atcgaactga gcaagaatga ctgccacacc aacgtcaaca accccgtggt gaccaacatc      420

ggaaaggatt acatcggact gaaatctagg ctggagcaag agtttttcgg caagacattc      480

gagaatgaca atctgcatgt gcagctggcc tacaatatcc tcgacatcaa gaaaattctg      540

ggaacctatg tgaacaatat catttatatc ttctacaatc tgaatagggc tggcaccggc      600

agagatgaga ggatgtatga cgacctcatc ggcacactgt acgcttacaa acccatggag      660

gctcaacaga cctatctgct caaaggcgac aaggatatga ggaggtttga ggaggtgaaa      720

cagctgctgc aaaacacctc cgcttactat gtgtattacg gcacactgtt cgagaaggtg      780

aaggctaaga gcaagaagga acagagggct aaggaggccg aaatcgacgc ttgtaccgcc      840

cataactacg atgtgctgag actgctgtcc ctcatgaggc agctgtgcat gcactccgtc      900

gctggaacag cctttaagct ggctgagtcc gctctgttca acattgagga tgtgctcagc      960

gccgatctga aggaaatcct cgatgaagcc ttctccggcg ccgtgaacaa gctcaatgac     1020

ggattcgtgc agcactccgg caacaatctg tacgtgctcc agcagctgta ccctaatgag     1080

accatcgaga gaatcgccga gaagtactac agactcaccg tgaggaagga ggatctgaac     1140

atgggagtca acattaaaaa gctgagggag ctgatcgtgg gccaatactt tcccgaggtc     1200

ctcgacaaag aatacgacct ctccaagaat ggagacagcg tggtgacata cagaagcaag     1260

atttataccg tgatgaatta cattctgctg tattacctcg aggaccacga ctccagcaga     1320

gaaagcatgg tcgaagctct gagacaaaac agagagggcg atgaaggcaa ggaggagatc     1380

tatagacagt ttgccaagaa ggtgtggaac ggcgtgtccg gactgtttgg cgtgtgtctg     1440

aacctcttca agaccgaaaa gagaaacaag tttaggagca aagtcgccct ccccgatgtg     1500

tccggcgctg cctatatgct ctcctccgag aacatcgact actttgtcaa gatgctcttc     1560

tttgtgtgta agtttctgga tggcaaagaa atcaacgagc tgctgtgcgc tctgatcaac     1620

aaatttgata atattgccga tattctggat gctgccgctc aatgtggctc ctccgtctgg     1680

ttcgtggaca gctataggtt cttcgagaga tctaggagga ttagcgccca gattagaatc     1740

gtgaagaaca tcgcttccaa ggattttaag aaatccaaga aggattccga tgagagctac     1800

cccgagcagc tgtatctgga tgctctggct ctgctcggag acgtcatctc caagtacaag     1860

cagaatagag atggcagcgt cgtcatcgat gaccaaggca atgccgtgct gacagagcaa     1920

tacaagaggt ttagatatga atttttcgag gagatcaaga gggacgaaag cggcggcatc     1980

aagtacaaga agtccggaaa acccgagtac aaccatcaga gaaggaattt tattctgaat     2040

aatgtgctga aaagcaaatg gtttttctat gtggtgaagt acaataggcc cagcagctgc     2100

agagaactga tgaagaataa ggaaattctg aggttcgtgc tgagagacat ccccgactcc     2160

caagtgagaa gatactttaa ggccgtccaa ggagaggaag cttacgctag cgccgaagct     2220

atgaggacaa gactggtcga cgctctgtcc caatttagcg tcacagcttg tctggatgaa     2280

gtgggcggca tgacagacaa ggaattcgcc tcccagaggg ccgtcgatag caaagaaaaa     2340

ctgagagcca tcatcagact gtatctgaca gtcgcctatc tgattaccaa gagcatggtg     2400

aaggtgaata caaggtttag cattgccttt agcgtgctgg agagggacta ctatctgctc     2460

attgacggca agaagaaatc cagcgactac accggagagg atatgctggc tctgaccaga     2520

aaatttgtgg gcgaagatgc tggactgtat agagagtgga aagagaagaa cgctgaagcc     2580

aaggacaaat attttgacaa ggccgaaagg aagaaggtgc tgagacagaa cgataagatg     2640

atcagaaaga tgcacttcac accccactcc ctcaattacg tccaaaagaa tctcgaaagc     2700

gtccagagca acggactggc cgccgtcatc aaggaatata gaaatgccgt cgctgccctc     2760

aatatcatca atagactgga cgagtacatt ggctccgcta gggctgatag ctactactct     2820

ctgtactgtt actgcctcca aatgtatctg agcaagaact tcagcgtggg ctacctcatc     2880

aacgtgcaaa agcagctgga ggagcaccac acctacatga aggatctcat gtggctgctc     2940

aacatcccct tcgcttacaa cctcgccaga tacaaaaatc tgtccaacga aaaactcttt     3000

tacgacgagg aagccgccgc cgaaaaggct gacaaggctg agaacgagag aggcgaa        3057


<210>  616
<211>  3057
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  dCas13d seq212 H914A

<400>  616
aagaagaagc accagagcgc cgccgagaag aggcaagtga agaagctcaa gaatcaagag       60

aaggcccaga agtacgctag cgagccttcc cccctccaga gcgatacagc tggcgtggaa      120

tgctcccaga aaaagacagt cgtcagccac attgccagct ccaagacact ggccaaggct      180

atgggactca aatccacact ggtcatgggc gacaagctgg tcatcaccag ctttgctgct      240

agcaaggctg tcggaggcgc tggctacaaa agcgctaaca ttgaaaaaat cacagatctg      300

caaggaaggg tcattgagga gcacgaaagg atgtttagcg ccgatgtcgg agagaaaaat      360

atcgaactga gcaagaatga ctgccacacc aacgtcaaca accccgtggt gaccaacatc      420

ggaaaggatt acatcggact gaaatctagg ctggagcaag agtttttcgg caagacattc      480

gagaatgaca atctgcatgt gcagctggcc tacaatatcc tcgacatcaa gaaaattctg      540

ggaacctatg tgaacaatat catttatatc ttctacaatc tgaatagggc tggcaccggc      600

agagatgaga ggatgtatga cgacctcatc ggcacactgt acgcttacaa acccatggag      660

gctcaacaga cctatctgct caaaggcgac aaggatatga ggaggtttga ggaggtgaaa      720

cagctgctgc aaaacacctc cgcttactat gtgtattacg gcacactgtt cgagaaggtg      780

aaggctaaga gcaagaagga acagagggct aaggaggccg aaatcgacgc ttgtaccgcc      840

cataactacg atgtgctgag actgctgtcc ctcatgaggc agctgtgcat gcactccgtc      900

gctggaacag cctttaagct ggctgagtcc gctctgttca acattgagga tgtgctcagc      960

gccgatctga aggaaatcct cgatgaagcc ttctccggcg ccgtgaacaa gctcaatgac     1020

ggattcgtgc agcactccgg caacaatctg tacgtgctcc agcagctgta ccctaatgag     1080

accatcgaga gaatcgccga gaagtactac agactcaccg tgaggaagga ggatctgaac     1140

atgggagtca acattaaaaa gctgagggag ctgatcgtgg gccaatactt tcccgaggtc     1200

ctcgacaaag aatacgacct ctccaagaat ggagacagcg tggtgacata cagaagcaag     1260

atttataccg tgatgaatta cattctgctg tattacctcg aggaccacga ctccagcaga     1320

gaaagcatgg tcgaagctct gagacaaaac agagagggcg atgaaggcaa ggaggagatc     1380

tatagacagt ttgccaagaa ggtgtggaac ggcgtgtccg gactgtttgg cgtgtgtctg     1440

aacctcttca agaccgaaaa gagaaacaag tttaggagca aagtcgccct ccccgatgtg     1500

tccggcgctg cctatatgct ctcctccgag aacatcgact actttgtcaa gatgctcttc     1560

tttgtgtgta agtttctgga tggcaaagaa atcaacgagc tgctgtgcgc tctgatcaac     1620

aaatttgata atattgccga tattctggat gctgccgctc aatgtggctc ctccgtctgg     1680

ttcgtggaca gctataggtt cttcgagaga tctaggagga ttagcgccca gattagaatc     1740

gtgaagaaca tcgcttccaa ggattttaag aaatccaaga aggattccga tgagagctac     1800

cccgagcagc tgtatctgga tgctctggct ctgctcggag acgtcatctc caagtacaag     1860

cagaatagag atggcagcgt cgtcatcgat gaccaaggca atgccgtgct gacagagcaa     1920

tacaagaggt ttagatatga atttttcgag gagatcaaga gggacgaaag cggcggcatc     1980

aagtacaaga agtccggaaa acccgagtac aaccatcaga gaaggaattt tattctgaat     2040

aatgtgctga aaagcaaatg gtttttctat gtggtgaagt acaataggcc cagcagctgc     2100

agagaactga tgaagaataa ggaaattctg aggttcgtgc tgagagacat ccccgactcc     2160

caagtgagaa gatactttaa ggccgtccaa ggagaggaag cttacgctag cgccgaagct     2220

atgaggacaa gactggtcga cgctctgtcc caatttagcg tcacagcttg tctggatgaa     2280

gtgggcggca tgacagacaa ggaattcgcc tcccagaggg ccgtcgatag caaagaaaaa     2340

ctgagagcca tcatcagact gtatctgaca gtcgcctatc tgattaccaa gagcatggtg     2400

aaggtgaata caaggtttag cattgccttt agcgtgctgg agagggacta ctatctgctc     2460

attgacggca agaagaaatc cagcgactac accggagagg atatgctggc tctgaccaga     2520

aaatttgtgg gcgaagatgc tggactgtat agagagtgga aagagaagaa cgctgaagcc     2580

aaggacaaat attttgacaa ggccgaaagg aagaaggtgc tgagacagaa cgataagatg     2640

atcagaaaga tgcacttcac accccactcc ctcaattacg tccaaaagaa tctcgaaagc     2700

gtccagagca acggactggc cgccgtcatc aaggaatatg caaatgccgt cgctcacctc     2760

aatatcatca atagactgga cgagtacatt ggctccgcta gggctgatag ctactactct     2820

ctgtactgtt actgcctcca aatgtatctg agcaagaact tcagcgtggg ctacctcatc     2880

aacgtgcaaa agcagctgga ggagcaccac acctacatga aggatctcat gtggctgctc     2940

aacatcccct tcgcttacaa cctcgccaga tacaaaaatc tgtccaacga aaaactcttt     3000

tacgacgagg aagccgccgc cgaaaaggct gacaaggctg agaacgagag aggcgaa        3057


<210>  617
<211>  3057
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  dCas13d seq212 H293A

<400>  617
aagaagaagc accagagcgc cgccgagaag aggcaagtga agaagctcaa gaatcaagag       60

aaggcccaga agtacgctag cgagccttcc cccctccaga gcgatacagc tggcgtggaa      120

tgctcccaga aaaagacagt cgtcagccac attgccagct ccaagacact ggccaaggct      180

atgggactca aatccacact ggtcatgggc gacaagctgg tcatcaccag ctttgctgct      240

agcaaggctg tcggaggcgc tggctacaaa agcgctaaca ttgaaaaaat cacagatctg      300

caaggaaggg tcattgagga gcacgaaagg atgtttagcg ccgatgtcgg agagaaaaat      360

atcgaactga gcaagaatga ctgccacacc aacgtcaaca accccgtggt gaccaacatc      420

ggaaaggatt acatcggact gaaatctagg ctggagcaag agtttttcgg caagacattc      480

gagaatgaca atctgcatgt gcagctggcc tacaatatcc tcgacatcaa gaaaattctg      540

ggaacctatg tgaacaatat catttatatc ttctacaatc tgaatagggc tggcaccggc      600

agagatgaga ggatgtatga cgacctcatc ggcacactgt acgcttacaa acccatggag      660

gctcaacaga cctatctgct caaaggcgac aaggatatga ggaggtttga ggaggtgaaa      720

cagctgctgc aaaacacctc cgcttactat gtgtattacg gcacactgtt cgagaaggtg      780

aaggctaaga gcaagaagga acagagggct aaggaggccg aaatcgacgc ttgtaccgcc      840

cataactacg atgtgctgag actgctgtcc ctcatggcgc agctgtgcat gcactccgtc      900

gctggaacag cctttaagct ggctgagtcc gctctgttca acattgagga tgtgctcagc      960

gccgatctga aggaaatcct cgatgaagcc ttctccggcg ccgtgaacaa gctcaatgac     1020

ggattcgtgc agcactccgg caacaatctg tacgtgctcc agcagctgta ccctaatgag     1080

accatcgaga gaatcgccga gaagtactac agactcaccg tgaggaagga ggatctgaac     1140

atgggagtca acattaaaaa gctgagggag ctgatcgtgg gccaatactt tcccgaggtc     1200

ctcgacaaag aatacgacct ctccaagaat ggagacagcg tggtgacata cagaagcaag     1260

atttataccg tgatgaatta cattctgctg tattacctcg aggaccacga ctccagcaga     1320

gaaagcatgg tcgaagctct gagacaaaac agagagggcg atgaaggcaa ggaggagatc     1380

tatagacagt ttgccaagaa ggtgtggaac ggcgtgtccg gactgtttgg cgtgtgtctg     1440

aacctcttca agaccgaaaa gagaaacaag tttaggagca aagtcgccct ccccgatgtg     1500

tccggcgctg cctatatgct ctcctccgag aacatcgact actttgtcaa gatgctcttc     1560

tttgtgtgta agtttctgga tggcaaagaa atcaacgagc tgctgtgcgc tctgatcaac     1620

aaatttgata atattgccga tattctggat gctgccgctc aatgtggctc ctccgtctgg     1680

ttcgtggaca gctataggtt cttcgagaga tctaggagga ttagcgccca gattagaatc     1740

gtgaagaaca tcgcttccaa ggattttaag aaatccaaga aggattccga tgagagctac     1800

cccgagcagc tgtatctgga tgctctggct ctgctcggag acgtcatctc caagtacaag     1860

cagaatagag atggcagcgt cgtcatcgat gaccaaggca atgccgtgct gacagagcaa     1920

tacaagaggt ttagatatga atttttcgag gagatcaaga gggacgaaag cggcggcatc     1980

aagtacaaga agtccggaaa acccgagtac aaccatcaga gaaggaattt tattctgaat     2040

aatgtgctga aaagcaaatg gtttttctat gtggtgaagt acaataggcc cagcagctgc     2100

agagaactga tgaagaataa ggaaattctg aggttcgtgc tgagagacat ccccgactcc     2160

caagtgagaa gatactttaa ggccgtccaa ggagaggaag cttacgctag cgccgaagct     2220

atgaggacaa gactggtcga cgctctgtcc caatttagcg tcacagcttg tctggatgaa     2280

gtgggcggca tgacagacaa ggaattcgcc tcccagaggg ccgtcgatag caaagaaaaa     2340

ctgagagcca tcatcagact gtatctgaca gtcgcctatc tgattaccaa gagcatggtg     2400

aaggtgaata caaggtttag cattgccttt agcgtgctgg agagggacta ctatctgctc     2460

attgacggca agaagaaatc cagcgactac accggagagg atatgctggc tctgaccaga     2520

aaatttgtgg gcgaagatgc tggactgtat agagagtgga aagagaagaa cgctgaagcc     2580

aaggacaaat attttgacaa ggccgaaagg aagaaggtgc tgagacagaa cgataagatg     2640

atcagaaaga tgcacttcac accccactcc ctcaattacg tccaaaagaa tctcgaaagc     2700

gtccagagca acggactggc cgccgtcatc aaggaatata gaaatgccgt cgctcacctc     2760

aatatcatca atagactgga cgagtacatt ggctccgcta gggctgatag ctactactct     2820

ctgtactgtt actgcctcca aatgtatctg agcaagaact tcagcgtggg ctacctcatc     2880

aacgtgcaaa agcagctgga ggagcaccac acctacatga aggatctcat gtggctgctc     2940

aacatcccct tcgcttacaa cctcgccaga tacaaaaatc tgtccaacga aaaactcttt     3000

tacgacgagg aagccgccgc cgaaaaggct gacaaggctg agaacgagag aggcgaa        3057


<210>  618
<211>  3057
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  dCas13d seq212 H298A

<400>  618
aagaagaagc accagagcgc cgccgagaag aggcaagtga agaagctcaa gaatcaagag       60

aaggcccaga agtacgctag cgagccttcc cccctccaga gcgatacagc tggcgtggaa      120

tgctcccaga aaaagacagt cgtcagccac attgccagct ccaagacact ggccaaggct      180

atgggactca aatccacact ggtcatgggc gacaagctgg tcatcaccag ctttgctgct      240

agcaaggctg tcggaggcgc tggctacaaa agcgctaaca ttgaaaaaat cacagatctg      300

caaggaaggg tcattgagga gcacgaaagg atgtttagcg ccgatgtcgg agagaaaaat      360

atcgaactga gcaagaatga ctgccacacc aacgtcaaca accccgtggt gaccaacatc      420

ggaaaggatt acatcggact gaaatctagg ctggagcaag agtttttcgg caagacattc      480

gagaatgaca atctgcatgt gcagctggcc tacaatatcc tcgacatcaa gaaaattctg      540

ggaacctatg tgaacaatat catttatatc ttctacaatc tgaatagggc tggcaccggc      600

agagatgaga ggatgtatga cgacctcatc ggcacactgt acgcttacaa acccatggag      660

gctcaacaga cctatctgct caaaggcgac aaggatatga ggaggtttga ggaggtgaaa      720

cagctgctgc aaaacacctc cgcttactat gtgtattacg gcacactgtt cgagaaggtg      780

aaggctaaga gcaagaagga acagagggct aaggaggccg aaatcgacgc ttgtaccgcc      840

cataactacg atgtgctgag actgctgtcc ctcatgaggc agctgtgcat ggcctccgtc      900

gctggaacag cctttaagct ggctgagtcc gctctgttca acattgagga tgtgctcagc      960

gccgatctga aggaaatcct cgatgaagcc ttctccggcg ccgtgaacaa gctcaatgac     1020

ggattcgtgc agcactccgg caacaatctg tacgtgctcc agcagctgta ccctaatgag     1080

accatcgaga gaatcgccga gaagtactac agactcaccg tgaggaagga ggatctgaac     1140

atgggagtca acattaaaaa gctgagggag ctgatcgtgg gccaatactt tcccgaggtc     1200

ctcgacaaag aatacgacct ctccaagaat ggagacagcg tggtgacata cagaagcaag     1260

atttataccg tgatgaatta cattctgctg tattacctcg aggaccacga ctccagcaga     1320

gaaagcatgg tcgaagctct gagacaaaac agagagggcg atgaaggcaa ggaggagatc     1380

tatagacagt ttgccaagaa ggtgtggaac ggcgtgtccg gactgtttgg cgtgtgtctg     1440

aacctcttca agaccgaaaa gagaaacaag tttaggagca aagtcgccct ccccgatgtg     1500

tccggcgctg cctatatgct ctcctccgag aacatcgact actttgtcaa gatgctcttc     1560

tttgtgtgta agtttctgga tggcaaagaa atcaacgagc tgctgtgcgc tctgatcaac     1620

aaatttgata atattgccga tattctggat gctgccgctc aatgtggctc ctccgtctgg     1680

ttcgtggaca gctataggtt cttcgagaga tctaggagga ttagcgccca gattagaatc     1740

gtgaagaaca tcgcttccaa ggattttaag aaatccaaga aggattccga tgagagctac     1800

cccgagcagc tgtatctgga tgctctggct ctgctcggag acgtcatctc caagtacaag     1860

cagaatagag atggcagcgt cgtcatcgat gaccaaggca atgccgtgct gacagagcaa     1920

tacaagaggt ttagatatga atttttcgag gagatcaaga gggacgaaag cggcggcatc     1980

aagtacaaga agtccggaaa acccgagtac aaccatcaga gaaggaattt tattctgaat     2040

aatgtgctga aaagcaaatg gtttttctat gtggtgaagt acaataggcc cagcagctgc     2100

agagaactga tgaagaataa ggaaattctg aggttcgtgc tgagagacat ccccgactcc     2160

caagtgagaa gatactttaa ggccgtccaa ggagaggaag cttacgctag cgccgaagct     2220

atgaggacaa gactggtcga cgctctgtcc caatttagcg tcacagcttg tctggatgaa     2280

gtgggcggca tgacagacaa ggaattcgcc tcccagaggg ccgtcgatag caaagaaaaa     2340

ctgagagcca tcatcagact gtatctgaca gtcgcctatc tgattaccaa gagcatggtg     2400

aaggtgaata caaggtttag cattgccttt agcgtgctgg agagggacta ctatctgctc     2460

attgacggca agaagaaatc cagcgactac accggagagg atatgctggc tctgaccaga     2520

aaatttgtgg gcgaagatgc tggactgtat agagagtgga aagagaagaa cgctgaagcc     2580

aaggacaaat attttgacaa ggccgaaagg aagaaggtgc tgagacagaa cgataagatg     2640

atcagaaaga tgcacttcac accccactcc ctcaattacg tccaaaagaa tctcgaaagc     2700

gtccagagca acggactggc cgccgtcatc aaggaatata gaaatgccgt cgctcacctc     2760

aatatcatca atagactgga cgagtacatt ggctccgcta gggctgatag ctactactct     2820

ctgtactgtt actgcctcca aatgtatctg agcaagaact tcagcgtggg ctacctcatc     2880

aacgtgcaaa agcagctgga ggagcaccac acctacatga aggatctcat gtggctgctc     2940

aacatcccct tcgcttacaa cctcgccaga tacaaaaatc tgtccaacga aaaactcttt     3000

tacgacgagg aagccgccgc cgaaaaggct gacaaggctg agaacgagag aggcgaa        3057


<210>  619
<211>  448
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  human synapsin promoter

<400>  619
agtgcaagtg ggttttagga ccaggatgag gcggggtggg ggtgcctacc tgacgaccga       60

ccccgaccca ctggacaagc acccaacccc cattccccaa attgcgcatc ccctatcaga      120

gagggggagg ggaaacagga tgcggcgagg cgcgtgcgca ctgccagctt cagcaccgcg      180

gacagtgcct tcgcccccgc ctggcggcgc gcgccaccgc cgcctcagca ctgaaggcgc      240

gctgacgtca ctcgccggtc ccccgcaaac tccccttccc ggccaccttg gtcgcgtccg      300

cgccgccgcc ggcccagccg gaccgcacca cgcgaggcgc gagatagggg ggcacgggcg      360

cgaccatctg cgctgcggcg ccggcgactc agcgctgcct cagtctgcgg tgggcagcgg      420

aggagtcgtg tcgtgcctga gagcgcag                                         448


<210>  620
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  620

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  621
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  621

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Ala 
    


<210>  622
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  622

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala 
            20          


<210>  623
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  623

Tyr Val Glu Phe Glu Gly Glu Gln Gly Val Asp Glu Gly Gly Val Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  624
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  624

Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu Glu Thr Thr Glu Tyr 
1               5                   10                  15      


Asp Gly Gly Tyr 
            20  


<210>  625
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  625

Ala Ser Ser Thr Ser Pro Val Glu Ile Ser Glu Trp Leu Asp Gln Lys 
1               5                   10                  15      


Leu Thr Lys Ser Asp Arg Pro Glu Leu 
            20                  25  


<210>  626
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  626

Val Asn Gln Cys Arg Arg Gln Ser Glu Asp Ser Thr Phe Tyr Leu Gly 
1               5                   10                  15      


<210>  627
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  627

Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
1               5                   10                  15      


Ser Met Gly Asn Tyr 
            20      


<210>  628
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  628

Leu Asp Glu Ala Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr 
1               5                   10                  15      


Glu Lys Ala Cys Gln 
            20      


<210>  629
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  629

Ser Ala Ala Ala Ala Thr Pro Ala Val Arg Thr Val Pro Gln Tyr Lys 
1               5                   10                  15      


Tyr Ala Ala Gly Val Arg Asn Pro Gln Gln His Leu Asn Ala Gln Pro 
            20                  25                  30          


Gln Val Thr Met Gln Gln Pro Ala Val His Val Gln Gly Gln Glu Pro 
        35                  40                  45              


Leu 
    


<210>  630
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  630

Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  631
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  631

Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Glu 
1               5                   10                  15      


Ala Ala Ala Lys Gly Gly Gly Gly Ser 
            20                  25  


<210>  632
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  632

Gly Gly Gly Gly Ser Ser Gly Ser Glu Thr Gly Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Gly Glu Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  633
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  633

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  634
<211>  212
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  human EF1a core promoter

<400>  634
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgat       60

ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac ag                                    212


<210>  635
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  modified UBB intron

<400>  635
gtaagtcccg cagccgtaac gaccttgggg gggtgtgaga ttctcattct aattttgaag       60

aatattaggt gtaaaagcaa gaaatacaat gatcctgagg tgacacgctt atgttttact      120

tttaaactag                                                             130


<210>  636
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  modified CMV enhancer

<400>  636
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catg                                                                   304


<210>  637
<211>  675
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  eCMV-EFS-UBB promoter

<400>  637
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggggcag agcgcacatc gcccacagtc cccgagaagt tggggggagg ggtcggcaat      360

tgatccggtg cctagagaag gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg      420

ctccgccttt ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac      480

gttctttttc gcaacgggtt tgccgccaga acacagaatt ccaggtaagt cccgcagccg      540

taacgacctt gggggggtgt gagattctca ttctaatttt gaagaatatt aggtgtaaaa      600

gcaagaaata caatgatcct gaggtgacac gcttatgttt tacttttaaa ctaggtgaat      660

tcatggcgcg ccacc                                                       675


<210>  638
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUFN5 sequence

<400>  638

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Tyr Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Asn Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Tyr Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Ile Met Glu 
        195                 200                 205             


Phe Ser Gln Asp Gln His Gly Ser Asn Phe Ile Glu Leu Lys Leu Glu 
    210                 215                 220                 


Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln 
225                 230                 235                 240 


Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln 
                245                 250                 255     


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            260                 265                 270         


Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser 
        275                 280                 285             


Tyr Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn 
    290                 295                 300                 


Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp 
305                 310                 315                 320 


Gln Asn Gly Ser Asn Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro 
                325                 330                 335     


Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala 
            340                 345                 350         


Leu Ser Thr His Pro Tyr Gly Asn Tyr Val Ile Gln Arg Ile Leu Glu 
        355                 360                 365             


His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln 
    370                 375                 380                 


His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg 
385                 390                 395                 400 


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
                405                 410                 415     


Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser 
            420                 425                 430         


Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala 
        435                 440                 445             


Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala 
    450                 455                 460                 


Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys 
465                 470                 475                 480 


Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys 
                485                 490                 495     


Ile Arg Pro His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr 
            500                 505                 510         


Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
        515                 520                 525             


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
    530                 535                 540                 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
545                 550                 555                 560 


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
                565                 570                 575     


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
            580                 585                 590         


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
        595                 600                 605             


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
    610                 615                 620                 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
625                 630                 635                 640 


Val Asp Leu Gly 
                


<210>  639
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUFN0 sequence

<400>  639

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Tyr Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Asn Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Tyr Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Asn Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Tyr Val Val Gln 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Arg Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Asn Phe Ile Glu Leu 
                325                 330                 335     


Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu 
            340                 345                 350         


Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr 
        355                 360                 365             


Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala 
    370                 375                 380                 


Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met 
385                 390                 395                 400 


Tyr Gly Ser Tyr Val Ile Arg Lys Ala Leu Glu Phe Ile Pro Ser Asp 
                405                 410                 415     


Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys 
            420                 425                 430         


Val Lys Asp Gln Asn Gly Ser Asn Val Val Glu Lys Cys Ile Glu Cys 
        435                 440                 445             


Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln 
    450                 455                 460                 


Val Phe Ala Leu Ser Thr His Pro Tyr Gly Asn Tyr Val Ile Gln Arg 
465                 470                 475                 480 


Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu 
                485                 490                 495     


Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Tyr 
            500                 505                 510         


Val Ile Arg His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys 
        515                 520                 525             


Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys 
    530                 535                 540                 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
545                 550                 555                 560 


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
                565                 570                 575     


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
            580                 585                 590         


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
        595                 600                 605             


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
    610                 615                 620                 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
625                 630                 635                 640 


Val Asp Leu Gly 
                


<210>  640
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF targeting CUGf3 (DM1) w/ stacking mutations to C

<400>  640

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


His Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  641
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF targeting CUGf3 (DM1) w/ stacking mutations to C

<400>  641

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  642
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF targeting CUGf3 (DM1) w/ stacking mutations to C

<400>  642

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Asn Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  643
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF targeting CUGf3 (DM1) w/ stacking mutations to C

<400>  643

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Phe Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Phe Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  644
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF targeting CUGf3 (DM1) w/ stacking mutations to C

<400>  644

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Phe Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  645
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF targeting CUGf3 (DM1) w/ stacking mutations to C

<400>  645

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


His Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Phe Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  646
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF targeting CUGf3 (DM1) w/ stacking mutations to C

<400>  646

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Phe Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  647
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF targeting CUGf3 (DM1) w/ stacking mutations to C

<400>  647

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Asn Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Phe Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  648
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF targeting CUGf3 (DM1) w/ stacking mutations to C

<400>  648

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Phe Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Phe Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Phe Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  649
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF targeting CUGf3 (DM1) w/ stacking mutations to C

<400>  649

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Phe Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Tyr Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Phe Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210>  650
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  16PUF

<400>  650

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Asn Tyr Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Arg Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Asn Val Ile Glu 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Ser Tyr Val Ile Arg Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Asn Val Ile Glu His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


His Ile Met Glu Phe Ser Gln Asp Gln His Gly Asn Tyr Phe Ile Gln 
                245                 250                 255     


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            260                 265                 270         


Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser 
        275                 280                 285             


Tyr Val Ile Arg Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu 
    290                 295                 300                 


Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln 
305                 310                 315                 320 


Met Tyr Gly Ser Asn Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser 
                325                 330                 335     


Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys 
            340                 345                 350         


Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu 
        355                 360                 365             


Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly 
    370                 375                 380                 


Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Tyr Val Ile Arg 
385                 390                 395                 400 


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
                405                 410                 415     


Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser 
            420                 425                 430         


Asn Val Ile Glu His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser 
        435                 440                 445             


Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His 
    450                 455                 460                 


Lys Phe Ala Asn Tyr Val Val Gln Lys Cys Val Thr His Ala Ser Arg 
465                 470                 475                 480 


Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly 
                485                 490                 495     


Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Tyr 
            500                 505                 510         


Val Val Arg Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile 
        515                 520                 525             


Val Met His Lys Ile Arg Pro Asn Val Leu Val Leu Ser Gln His Lys 
    530                 535                 540                 


Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr 
545                 550                 555                 560 


Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro 
                565                 570                 575     


His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val 
            580                 585                 590         


Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val 
        595                 600                 605             


Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr 
    610                 615                 620                 


Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly 
625                 630                 635                 640 


Val Asp Leu Gly 
                


<210>  651
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  8PUF targeting CUGf3 (DM1) w/ stacking mutations

<400>  651

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Asn Phe Ile Glu Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Tyr Val Ile Arg 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser 
    130                 135                 140                 


Asn Val Val Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Asn Tyr Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


